From listmaster animalgenome.org Mon Mar 24 10:50:07 2025
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From: "isabelle caugant" <cauganteversoleassociates.com>
Postmaster: submission approved by list moderator
To: Members of AnGenMap <angenmapanimalgenome.org>
Subject: Animal Genetics and Gut Microbiome (9 April, 11:00am
EDT)
Date: Mon, 24 Mar 2025 10:50:08 -0500
The Phytobiomes Alliance is organizing a free webinar on the links between
animal genetics and gut microbiomes.
Title: Beyond the Host Genome: Host Genetics and Gut Microbiome Determinism
in Livestock
. Date: 9 April 2025
. Time: 11:00 AM EDT | 4:00 PM BST | 5:00 PM CEST
. Location: Zoom
. Presenters: Catherine Larzul & Jordi Estellé (INRAE, France)
Registration:
https://us06web.zoom.us/...cKmHC6hYbA
Description:
Animal-associated microbiomes play a crucial role in host physiology,
significantly influencing livestock phenotypes. Understanding these
associations is crucial for developing strategies to enhance livestock
productivity, improve animal health and welfare, and mitigate the
environmental impact of farming.
Beyond nutritional interventions like pre- and probiotics, leveraging
host genetics offers a promising approach to modulate microbiomes and
consequently, host-associated traits.
Building on our foundational work exploring pig enterotypes, we aimed
at further elucidating the host genetic determinism underpinning these
enterotypes. In this webinar, we will present our most recent
advancements in linking host genetics with the microbiome in pigs. In
a divergent selection experiment, we demonstrated the influence of host
genetics on gut microbiota. By structuring the gut microbiota into two
distinct enterotypes—one enriched in Prevotella and Mitsuokella, the
other in Ruminococcus and Treponema—we successfully drove the frequency
of these enterotypes across generations. The selection process increased
the average relative abundances of both directly and indirectly selected
bacterial taxa, significantly influencing the prevalence of the selected
enterotypes in each line. Based on the functional divergences between
enterotypes, analyzed using a pig metagenome catalogue previously
established, we will discuss hypotheses to be explored in future
research.
Overall, our recent findings highlight holobionts as units of selection
and emphasize the potential of incorporating microbiome data into breeding
and selection schemes. Future challenges include evaluating the feasibility
and cost-effectiveness of large-scale microbiome-informed breeding programs
and updating statistical and modeling approaches to integrate microbiome
data effectively.
This webinar is organized by the Phytobiomes Alliance Animal Microbiomes
Working Group.
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