Release 56
(Apr 24, 2025)

Whole genome analysis for QTL/association enrichment

Version: Enrich S: beta v0.8
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Data:

Number of immune capacity traits:65
Number of QTL / associations found:3,897
Number of chromosomes where QTL / associations are found:19

Chi-squared (χ2) test: are immune capacity traits over-represented on some chromosomes?

Chromosomes Total χ2 df p-values FDR * Size of χ2
Chromosome X10509.48795189e-411.005882e-40
Chromosome 14881.09180189e-411.005882e-40
Chromosome 25447.24375189e-411.005882e-40
Chromosome 31553282.63610189e-411.005882e-40
Chromosome 46220.78860189e-411.005882e-40
Chromosome 57822.00380189e-411.005882e-40
Chromosome 6215.96965186.269836e-366.618160e-36
Chromosome 76044.45335189e-411.005882e-40
Chromosome 83112.64785189e-411.005882e-40
Chromosome 99062.55805189e-411.005882e-40
Chromosome 1010394.38270189e-411.005882e-40
Chromosome 118022.42480189e-411.005882e-40
Chromosome 124126.17725189e-411.005882e-40
Chromosome 13927.71705181.913837e-1851.818145e-184
Chromosome 1411.01230180.8938348.938340e-01
Chromosome 151302.33870181.288653e-2652.448441e-264
Chromosome 169496.35830189e-411.005882e-40
Chromosome 175282.31665189e-411.005882e-40
Chromosome 1810052.87010189e-411.005882e-40

Chi-squared (χ2) test: Which of the 65 immune capacity traits are over-represented in the QTLdb

Traits Total χ2 df p-values FDR * Size of χ2
Band-formed neutrophil number 47.1111 64 0.9439222 1.000000e+00
Basophil number 1709.31876 64 9e-41 3.656250e-40
Basophil percentage 404.83369 64 5.51883e-51 3.985822e-50
C-reactive protein level 117.9077 64 4.749655e-05 7.529941e-05
C3c concentration 319.26479 64 1.403572e-35 5.068454e-35
CD2-positive leukocyte number 47.1111 64 0.9439222 1.000000e+00
CD3-negative leukocyte percentage 270.02235 64 4.017056e-27 1.243374e-26
CD3-negative, CD8-negative leukocyte percentage 401.69873 64 2.082275e-50 1.353479e-49
CD3-negative, CD8-positive leukocyte percentage 6.10995 64 1 1.000000e+00
CD3-positive leukocyte percentage 270.02235 64 4.017056e-27 1.243374e-26
CD4-negative, CD8-negative leukocyte percentage 153.34339 64 2.688841e-09 5.461708e-09
CD4-negative, CD8-positive leukocyte percentage 25.236 64 0.9999966 1.000000e+00
CD4-positive leukocyte number 40.43765 64 0.9906573 1.000000e+00
CD4-positive leukocyte percentage 187.26443 64 5.088234e-14 1.181197e-13
CD4-positive, CD8-negative leukocyte percentage 321.10901 64 6.663823e-36 2.547932e-35
CD4-positive, CD8-positive leukocyte percentage 221.99487 64 2.656517e-19 6.906944e-19
CD4-positive/CD8-positive leukocyte ratio 503.27358 64 1.911304e-69 2.070579e-68
CD8-negative leukocyte percentage 546.85688 64 8.525168e-78 1.108272e-76
CD8-positive leukocyte number 47.1111 64 0.9439222 1.000000e+00
CD8-positive leukocyte percentage 455.33265 64 2.239944e-60 2.079948e-59
Change in interferon-gamma level 123.47718 64 1.174404e-05 1.908407e-05
Eosinophil number 195.34437 64 3.253239e-15 7.831872e-15
Eosinophil percentage 150.82895 64 5.722606e-09 1.127180e-08
Gamma-delta T cell percentage 168.43477 64 2.466948e-11 5.172633e-11
Granular leukocyte to lymphocyte ratio 170.22432 64 1.391040e-11 3.013920e-11
Granulocyte number 124.3251 64 9.444171e-06 1.574029e-05
Granulocyte percentage 170.64881 64 1.213691e-11 2.720342e-11
Hemolytic complement activity (alternative pathway) 59.74851 64 0.6274625 9.058995e-01
Hemolytic complement activity (classical pathway) 211.89223 64 9.973124e-18 2.493281e-17
IgM-positive leukocyte number 35.76414 64 0.9983582 1.000000e+00
Immunocrit 90.43045 64 0.01649502 2.493433e-02
Immunoglobulin G level 393.38846 64 6.971091e-49 4.119281e-48
Interferon-gamma level 364.70378 64 1.145833e-43 6.206595e-43
Interferon-gamma to interleukin-10 ratio 302.90999 64 9.914067e-33 3.391654e-32
Interleukin-1 beta level 351.93422 64 2.266429e-41 1.133215e-40
Interleukin-10 level 235.46849 64 1.916953e-21 5.191748e-21
Interleukin-12 level 2459.64246 64 9e-41 3.656250e-40
Interleukin-2 level 57.46002 64 0.7052381 9.550099e-01
Interleukin-4 level 411.15457 64 3.772927e-52 3.065503e-51
Interleukin-6 level 127.04863 64 4.647993e-06 7.950514e-06
Interleukin-8 level 2850.29787 64 9e-41 3.656250e-40
Intermediate cell mass count 58.95384 64 0.655035 9.058995e-01
Intermediate cell mass percentage 58.95384 64 0.655035 9.058995e-01
Lymphocyte number 1420.21313 64 1.258929e-254 8.183038e-253
Lymphocyte percentage 100.33455 64 0.002509272 3.883397e-03
Lysozyme level 130.86204 64 1.684934e-06 3.042242e-06
MHCII-positive leukocyte number 35.76414 64 0.9983582 1.000000e+00
Monocyte number 252.15832 64 3.720044e-24 1.099104e-23
Monocyte percentage 147.04755 64 1.754701e-08 3.354575e-08
N1c-positive leukocyte number 35.76414 64 0.9983582 1.000000e+00
Neutrophil count 1339.63966 64 6.473914e-238 2.104022e-236
Neutrophil percentage 565.10517 64 2.560279e-81 4.160453e-80
PHA-induced proliferation 47.1111 64 0.9439222 1.000000e+00
PWM-induced cell proliferation 46.35901 64 0.9526108 1.000000e+00
Phagocytic activity 130.10102 64 2.067259e-06 3.631671e-06
Segmented neutrophil number 61.87257 64 0.5521247 8.156388e-01
Spontaneous cell proliferation 24.80793 64 0.9999976 1.000000e+00
Stress-induced alteration in number of neutrophils 35.76414 64 0.9983582 1.000000e+00
Toll-like receptor 2 level 35.19771 64 0.9987139 1.000000e+00
Toll-like receptor 9 level 131.09441 64 1.582633e-06 2.939176e-06
Tumor necrosis factor alpha level 238.32707 64 6.645586e-22 1.878100e-21
White blood cell number 775.96997 64 7.491394e-123 1.623135e-121
conA-induced cell proliferation 45.46417 64 0.961606 1.000000e+00
post-stress mitogen induced IL-2 activity 30.29757 64 0.9998924 1.000000e+00
stress-induced leukocyte proliferation 51.66215 64 0.8664454 1.000000e+00

Correlations found between some of these traits for your reference

No correlation data found on these traits

Overall Test

Data Chi'Square Test Fisher's Exact Test
Number of chrom.:19 χ2=1656214.478750
Number of traits:65 df=1152
Number of QTLs:3,897 p-value=0

FOOT NOTE: * : FDR is short for "false discovery rate", representing the expected proportion of type I errors. A type I error is where you incorrectly reject the null hypothesis, i.e. you get a false positive. It's statistical definition is FDR = E(V/R | R > 0) P(R > 0), where V = Number of Type I errors (false positives); R = Number of rejected hypotheses. Benjamini–Hochberg procedure is a practical way to estimate FDR.

 

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