format-version: 1.2 date: 07:05:2009 20:00 saved-by: caripark auto-generated-by: OBO-Edit 2.0 subsetdef: slim_cattle "ATO Cattle Slim" subsetdef: slim_chkn "ATO Chicken Slim" subsetdef: slim_pig "ATO Pig Slim" default-namespace: ATO_namespace [Term] id: ATO:0000000 name: Trait is_obsolete: true [Term] id: ATO:0000001 name: Development trait is_obsolete: true [Term] id: ATO:0000002 name: Exterior trait is_obsolete: true [Term] id: ATO:0000003 name: Immune function trait subset: slim_cattle subset: slim_chkn subset: slim_pig is_obsolete: true [Term] id: ATO:0000004 name: product quality def: "characteristics related to the ability of a product produced by or obtained from the body of an animal to meet certain standards" [CP:Cari Park_Iowa State University curator] subset: slim_cattle subset: slim_chkn subset: slim_pig is_a: ID:0000701 ! product trait [Term] id: ATO:0000005 name: production trait subset: slim_cattle subset: slim_chkn subset: slim_pig is_obsolete: true [Term] id: ATO:0000006 name: Reproduction trait subset: slim_cattle subset: slim_pig is_obsolete: true [Term] id: ATO:0000007 name: growth is_obsolete: true [Term] id: ATO:0000008 name: physiology is_obsolete: true [Term] id: ID:0000000 name: conformation def: "characteristics relating to an organism's overall structure and proportions" [CP:Cari Park_Iowa State University curator] subset: slim_cattle subset: slim_pig is_a: MT:0005395 ! other trait created_by: caripark creation_date: 2008-11-10T10:09:36Z [Term] id: ID:0000001 name: pigmentation subset: slim_cattle subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-10T10:09:36Z [Term] id: ID:0000002 name: behavioral is_obsolete: true created_by: caripark creation_date: 2008-11-10T10:09:36Z [Term] id: ID:0000003 name: defects is_obsolete: true created_by: caripark creation_date: 2008-11-10T10:09:36Z [Term] id: ID:0000004 name: age subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-10T10:09:36Z [Term] id: ID:0000005 name: disease resistance subset: slim_cattle subset: slim_chkn subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-10T10:12:53Z [Term] id: ID:0000006 name: mastitis def: "inflammation of the parenchyma of the mammary gland" [CP:Cari Park_Iowa State University curator, MeSH:C17.800.090.968, MeSH:C22.196.581] subset: slim_cattle relationship: part_of MT:0001881 ! mammary gland physiology created_by: caripark creation_date: 2008-11-10T10:12:53Z [Term] id: ID:0000007 name: parasite load def: "number of parasites harbored by an organism" [CP:Cari Park_Iowa State University curator] subset: slim_cattle subset: slim_chkn subset: slim_pig is_a: ID:0000675 ! response to parasitic infection created_by: caripark creation_date: 2008-11-10T10:12:53Z [Term] id: ID:0000008 name: parasite resistance subset: slim_cattle subset: slim_chkn subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-10T10:12:53Z [Term] id: ID:0000009 name: postchallenge traits subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T10:12:53Z [Term] id: ID:0000010 name: red blood cell mass subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T10:12:53Z [Term] id: ID:0000011 name: immune capacity is_obsolete: true created_by: caripark creation_date: 2008-11-10T10:12:53Z [Term] id: ID:0000012 name: pathogen is_obsolete: true created_by: caripark creation_date: 2008-11-10T10:12:53Z [Term] id: ID:0000013 name: health other is_obsolete: true created_by: caripark creation_date: 2008-11-10T10:12:53Z [Term] id: ID:0000014 name: carcass trait subset: slim_cattle subset: slim_chkn subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-10T10:20:24Z [Term] id: ID:0000015 name: egg product quality def: "characteristics related to the ability of an egg to meet certain standards" [CP:Cari Park_Iowa State University curator] subset: slim_chkn is_a: ATO:0000004 ! product quality created_by: caripark creation_date: 2008-11-10T10:20:24Z [Term] id: ID:0000016 name: meat product quality def: "characteristics related to the ability of meat products to meet certain standards" [CP:Cari Park_Iowa State University curator] subset: slim_cattle subset: slim_chkn subset: slim_pig is_a: ATO:0000004 ! product quality created_by: caripark creation_date: 2008-11-10T10:20:24Z [Term] id: ID:0000017 name: feed intake def: "Amount of feed consumed" [CP:Cari Park_Iowa State University curator] subset: slim_cattle subset: slim_chkn subset: slim_pig synonym: "feed consumption" EXACT [] is_obsolete: true created_by: caripark creation_date: 2008-11-10T10:38:24Z [Term] id: ID:0000018 name: lifetime production subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T10:38:24Z [Term] id: ID:0000019 name: milk product quality def: "characteristics related to the ability of milk to meet certain standards" [CP:Cari Park_Iowa State University curator] subset: slim_cattle is_a: ATO:0000004 ! product quality created_by: caripark creation_date: 2008-11-10T10:38:24Z [Term] id: ID:0000020 name: egg production subset: slim_chkn is_obsolete: true created_by: caripark creation_date: 2008-11-10T10:38:24Z [Term] id: ID:0000021 name: production other is_obsolete: true created_by: caripark creation_date: 2008-11-10T10:38:24Z [Term] id: ID:0000022 name: digestive organ is_obsolete: true created_by: caripark creation_date: 2008-11-10T10:38:24Z [Term] id: ID:0000023 name: feed conversion def: "Measure of an animal's ability to convert feed into additional body mass" [CP:Cari Park_Iowa State University curator] subset: slim_chkn subset: slim_pig synonym: "feed efficiency" RELATED [] relationship: part_of MT:0001731 ! postnatal growth rate relationship: part_of MT:0002121 ! metabolism created_by: caripark creation_date: 2008-11-10T10:38:24Z [Term] id: ID:0000024 name: endocrine subset: slim_cattle subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-10T10:44:31Z [Term] id: ID:0000025 name: fertility subset: slim_cattle subset: slim_chkn subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-10T10:44:31Z [Term] id: ID:0000026 name: life history subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T10:44:31Z [Term] id: ID:0000027 name: reproductive organ subset: slim_cattle subset: slim_chkn subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-10T10:44:31Z [Term] id: ID:0000028 name: other reproductive is_obsolete: true created_by: caripark creation_date: 2008-11-10T10:44:31Z [Term] id: ID:0000029 name: 200 day wean weight def: "Body weight at weaning (approximately 200 days of age)" [CP:Cari Park_Iowa State University curator] comment: Cattle trait. subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T12:52:15Z [Term] id: ID:0000030 name: body weight (400 days) def: "Body weight at 400 days of age" [CP:Cari Park_Iowa State University curator] comment: Cattle trait. subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T12:52:15Z [Term] id: ID:0000031 name: adjusted weaning weight comment: Cattle trait. subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T12:52:15Z [Term] id: ID:0000032 name: adjusted yearling weight comment: Cattle trait. subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T12:52:15Z [Term] id: ID:0000033 name: average daily gain def: "Change in body weight over a period of time, divided by the number of days in the period" [CP:Cari Park_Iowa State University curator] subset: slim_cattle subset: slim_pig is_a: MT:0001731 ! postnatal growth rate is_a: MT:0005456 ! weight gain created_by: caripark creation_date: 2008-11-10T12:52:15Z [Term] id: ID:0000034 name: birth weight is_obsolete: true created_by: caripark creation_date: 2008-11-10T12:52:15Z [Term] id: ID:0000035 name: BWF scaled by BWI def: "Relative body weight (final body weight/initial body weight)" [CP:Cari Park_Iowa State University curator] comment: Cattle trait. subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T12:52:15Z [Term] id: ID:0000036 name: body weight (initial) def: "Body weight at the beginning of a test period" [CP:Cari Park_Iowa State University curator] subset: slim_cattle subset: slim_chkn is_obsolete: true created_by: caripark creation_date: 2008-11-10T12:52:15Z [Term] id: ID:0000037 name: lean to fat ratio subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T12:52:15Z [Term] id: ID:0000038 name: body weight (mean) subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T12:52:15Z [Term] id: ID:0000039 name: post-weaning average daily gain def: "Average daily change in body weight following weaning" [CP:Cari Park_Iowa State University curator] comment: Cattle trait. subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T12:52:15Z [Term] id: ID:0000040 name: post-weaning daily gain--pasture def: "Average daily change in body weight following weaning in animals maintained on pasture" [CP:Cari Park_Iowa State University curator] comment: Cattle trait. subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T12:52:15Z [Term] id: ID:0000041 name: pre-weaning average daily gain def: "Average daily change in body weight from birth to weaning" [CP:Cari Park_Iowa State University curator] comment: Cattle trait. subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T12:52:15Z [Term] id: ID:0000042 name: length of productive life def: "Length of time during which a livestock animal can be utilized for breeding or production" [CP:Cari Park_Iowa State University curator] comment: In dairy cows, the length of time a female is producing milk, prior to the age of 84 months subset: slim_cattle subset: slim_pig synonym: "functional herd life" EXACT [] synonym: "longevity" RELATED [] is_a: MT:0005372 ! life span/aging trait created_by: caripark creation_date: 2008-11-10T02:40:05Z [Term] id: ID:0000043 name: weaning weight comment: Cattle trait. is_obsolete: true created_by: caripark creation_date: 2008-11-10T12:52:15Z [Term] id: ID:0000044 name: body weight (1 year) def: "Body weight at 1 year of age" [CP:Cari Park_Iowa State University curator] comment: Cattle trait. is_obsolete: true created_by: caripark creation_date: 2008-11-10T12:52:15Z [Term] id: ID:0000045 name: metabolic disorder parameter is_obsolete: true created_by: caripark creation_date: 2008-11-10T12:56:21Z [Term] id: ID:0000046 name: corticosterone response def: "Concentration of corticosterone in the blood after manual restraint of a bird. Used as a measure of acute stress." [CP:Cari Park_Iowa State University curator] subset: slim_chkn is_obsolete: true created_by: caripark creation_date: 2008-11-10T01:14:43Z [Term] id: ID:0000047 name: circulating creatine kinase level def: "Concentration in the blood of the enzyme creatine kinase, which uses ATP to convert creatine to phosphocreatine and ADP. Elevated levels are indicative of muscle damage." [CP:Cari Park_Iowa State University curator] subset: slim_chkn subset: slim_pig synonym: "creatine kinase concentration" EXACT [] is_a: MT:0001570 ! circulating enzyme level created_by: caripark creation_date: 2008-11-10T01:14:43Z [Term] id: ID:0000048 name: fluid in the heart sac is_obsolete: true created_by: caripark creation_date: 2008-11-10T01:14:43Z [Term] id: ID:0000049 name: hematocrit value synonym: "packed cell volume" EXACT [] is_obsolete: true created_by: caripark creation_date: 2008-11-10T01:14:43Z [Term] id: ID:0000050 name: liver abnormalities def: "Liver that is lighter in color, has an abnormal surface texture, or both" [CP:Cari Park_Iowa State University curator] subset: slim_chkn is_obsolete: true created_by: caripark creation_date: 2008-11-10T01:14:43Z [Term] id: ID:0000051 name: mean blood cell volume subset: slim_chkn is_obsolete: true created_by: caripark creation_date: 2008-11-10T01:14:43Z [Term] id: ID:0000052 name: packed cell volume synonym: "hematocrit" EXACT [] is_obsolete: true created_by: caripark creation_date: 2008-11-10T01:14:43Z [Term] id: ID:0000053 name: plasma concentration of cholesterol subset: slim_chkn is_obsolete: true created_by: caripark creation_date: 2008-11-10T01:14:43Z [Term] id: ID:0000054 name: plasma concentration of glucose subset: slim_chkn is_obsolete: true created_by: caripark creation_date: 2008-11-10T01:14:43Z [Term] id: ID:0000055 name: circulating insulin-like growth factor level def: "Concentration in the blood of insulin-like growth factor (IGF), a polypeptide hormone similar in sequence to insulin" [CP:Cari Park_Iowa State University curator] subset: slim_chkn synonym: "plasma concentration of IGF" EXACT [] is_a: MT:0005418 ! circulating hormone level created_by: caripark creation_date: 2008-11-10T01:14:43Z [Term] id: ID:0000056 name: plasma concentration of insulin subset: slim_chkn is_obsolete: true created_by: caripark creation_date: 2008-11-10T01:14:43Z [Term] id: ID:0000057 name: plasma concentration of triglycerides subset: slim_chkn is_obsolete: true created_by: caripark creation_date: 2008-11-10T01:14:43Z [Term] id: ID:0000058 name: right ventricular weight as a percentage of body weight def: "Weight of the right ventricle of the heart divided by total body weight" [CP:Cari Park_Iowa State University curator] subset: slim_chkn is_obsolete: true created_by: caripark creation_date: 2008-11-10T01:14:43Z [Term] id: ID:0000059 name: total heart ventricle morphology def: "any measurable or observable characteristic related to the shape, structure, color or pattern of the lower chambers of the heart" [CP:Cari Park_Iowa State University curator] subset: slim_chkn is_a: MT:0005294 ! heart ventricle morphology created_by: caripark creation_date: 2008-11-10T01:14:43Z [Term] id: ID:0000060 name: troponin T concentration def: "Concentration in the blood of one of a complex of three regulatory proteins required for skeletal and cardiac muscle contraction. Used as an indicator for myocardial damage." [CP:Cari Park_Iowa State University curator] subset: slim_chkn relationship: part_of MT:0002972 ! cardiac muscle contractility created_by: caripark creation_date: 2008-11-10T01:14:43Z [Term] id: ID:0000061 name: frame score def: "A numerical rating of cattle skeletal size calculated based on hip height and age. Indicates the growth pattern and potential mature size of the animal." [CP:Cari Park_Iowa State University curator] subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T01:17:50Z [Term] id: ID:0000062 name: heart girth def: "circumference of an animal's girth measured immediately behind the front legs" [CP:Cari Park_Iowa State University curator] subset: slim_cattle relationship: part_of MT:0004134 ! chest morphology created_by: caripark creation_date: 2008-11-10T01:17:50Z [Term] id: ID:0000063 name: heart length subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T01:17:50Z [Term] id: ID:0000064 name: hip height def: "height of an animal measured from the ground to a point on the back directly above the hipbones" [CP:Cari Park_Iowa State University curator] subset: slim_cattle synonym: "height at sacrum" EXACT [] synonym: "stature" RELATED [] is_a: MT:0001253 ! body height created_by: caripark creation_date: 2008-11-10T01:17:50Z [Term] id: ID:0000065 name: hook height def: "height of an animal measured from the ground to the point of the hip (tuber sacrale)" [CP:Cari Park_Iowa State University curator] subset: slim_cattle is_a: MT:0001253 ! body height created_by: caripark creation_date: 2008-11-10T01:17:50Z [Term] id: ID:0000066 name: hip width def: "distance between the points of both hips" [CP:Cari Park_Iowa State University curator] subset: slim_cattle synonym: "hook width" EXACT [] relationship: part_of MT:0003956 ! body size created_by: caripark creation_date: 2008-11-10T01:17:50Z [Term] id: ID:0000067 name: udder morphology def: "any measurable or observable characteristic related to the shape, structure, color or pattern of the organ in certain species containing two or more mammary glands, each with its own nipple" [CP:Cari Park_Iowa State University curator] subset: slim_cattle is_a: MT:0001119 ! female reproductive anatomy created_by: caripark creation_date: 2008-11-10T01:17:50Z [Term] id: ID:0000068 name: degree of spotting def: "the proportion of unpigmented skin (white coat color) on an animal's body" [CP:Cari Park_Iowa State University curator] subset: slim_cattle relationship: part_of ID:0000353 ! spotted coat created_by: caripark creation_date: 2008-11-10T01:18:17Z [Term] id: ID:0000069 name: percentage decrease in body weight up to day 150 after challenge subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T01:27:20Z [Term] id: ID:0000070 name: white blood cell count subset: slim_cattle subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-10T01:27:53Z [Term] id: ID:0000071 name: PTA somatic cell score def: "Predicted transmitting ability for somatic cell score is a measure used to improve mastitis resistance. Bulls with low PTA are expected to have daughters with lower incidence of mastitis than bulls with high PTA." [CP:Cari Park_Iowa State University curator] subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T01:29:25Z [Term] id: ID:0000072 name: somatic cell count in milk def: "the number of somatic cells (leukocytes) per milliliter of milk; a high count is an indicator of mastitis." [CP:Cari Park_Iowa State University curator] subset: slim_cattle is_a: ID:0000006 ! mastitis relationship: part_of MT:0004047 ! milk composition created_by: caripark creation_date: 2008-11-10T01:29:25Z [Term] id: ID:0000073 name: somatic cell score def: "Transformation of the number of somatic cells in milk, used as an indicator of bacterial infection/mastitis. SCS=ln(SCC/100,000)+3" [CP:Cari Park_Iowa State University curator] subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T01:29:25Z [Term] id: ID:0000074 name: parasite detection rate def: "Number of times parasitic infection is detected in an individual following challenge" [CP:Cari Park_Iowa State University curator] subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T01:31:27Z [Term] id: ID:0000075 name: parasites-mean of natural logarithm def: "Mean of natural logarithm (ni + 1), ni = number of parasites detected at day i after challenge" [CP:Cari Park_Iowa State University curator] subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T01:31:27Z [Term] id: ID:0000076 name: susceptibility to gastrointestinal worms subset: slim_cattle synonym: "resistance to gastrointestinal worms" EXACT [] is_obsolete: true created_by: caripark creation_date: 2008-11-10T01:32:07Z [Term] id: ID:0000077 name: susceptibility to metastrongylus def: "Likelihood that an organism will develop ill effects from infection with nematodes of the genus Metastrongylus" [CP:Cari Park_Iowa State University curator] subset: slim_cattle synonym: "resistance to metastrongylus" EXACT [] is_obsolete: true created_by: caripark creation_date: 2008-11-10T01:32:07Z [Term] id: ID:0000078 name: susceptibility to trypanosomosis def: "Likelihood that an organism will develop ill effects from infection with parasitic protozoans of the genus Trypanosoma" [CP:Cari Park_Iowa State University curator] subset: slim_cattle synonym: "resistance to trypanosomosis" EXACT [] is_obsolete: true created_by: caripark creation_date: 2008-11-10T01:32:07Z [Term] id: ID:0000079 name: final packed red blood cell volume subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T01:35:08Z [Term] id: ID:0000080 name: initial packed red blood cell volume subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T01:35:08Z [Term] id: ID:0000081 name: minimum packed red blood cell volume subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T01:35:08Z [Term] id: ID:0000082 name: packed red blood cell volume subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T01:35:08Z [Term] id: ID:0000083 name: PCV variance subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T01:35:08Z [Term] id: ID:0000084 name: PCVF subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T01:35:08Z [Term] id: ID:0000085 name: PCVF minus PCVM subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T01:35:08Z [Term] id: ID:0000086 name: PCVFM subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T01:35:08Z [Term] id: ID:0000087 name: PCVI subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T01:35:08Z [Term] id: ID:0000088 name: PCVI minus PCVF subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T01:35:08Z [Term] id: ID:0000089 name: PCVI minus PCVM subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T01:35:08Z [Term] id: ID:0000090 name: PCVM subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T01:35:08Z [Term] id: ID:0000091 name: percentage decrease in PCV up to day 100 after challenge subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T01:35:08Z [Term] id: ID:0000092 name: percentage decrease in PCV up to day 150 after challenge subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T01:35:08Z [Term] id: ID:0000093 name: adjusted fat thickness subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T01:40:23Z [Term] id: ID:0000094 name: adjusted mature weight subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T01:40:23Z [Term] id: ID:0000095 name: anatomy subset: slim_cattle subset: slim_chkn subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-10T01:40:23Z [Term] id: ID:0000096 name: body condition score def: "Scoring system used to estimate energy reserves (fat and muscle) in beef cows. Scores are based on fat deposition in relation to skeletal features." [CP:Cari Park_Iowa State University curator] subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T01:40:23Z [Term] id: ID:0000097 name: chemical subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-10T01:40:23Z [Term] id: ID:0000098 name: enzyme activity is_obsolete: true created_by: caripark creation_date: 2008-11-10T01:40:23Z [Term] id: ID:0000099 name: fat composition subset: slim_cattle subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-10T01:40:23Z [Term] id: ID:0000100 name: fat deposition subset: slim_cattle subset: slim_chkn subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-10T01:40:23Z [Term] id: ID:0000101 name: fatty acid content def: "Measure of the fatty acids present in a fat sample" [CP:Cari Park_Iowa State University curator] subset: slim_cattle subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-10T01:40:23Z [Term] id: ID:0000102 name: meat flavor def: "characteristics related to the distinctive taste of meat" [CP:Cari Park_Iowa State University curator] subset: slim_cattle subset: slim_pig relationship: part_of ID:0000016 ! meat product quality created_by: caripark creation_date: 2008-11-10T01:40:23Z [Term] id: ID:0000103 name: mature weight subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T01:40:23Z [Term] id: ID:0000104 name: meat color def: "characteristics related to the color of meat" [CP:Cari Park_Iowa State University curator] subset: slim_cattle subset: slim_chkn subset: slim_pig relationship: part_of ID:0000016 ! meat product quality created_by: caripark creation_date: 2008-11-10T01:40:23Z [Term] id: ID:0000105 name: muscling subset: slim_cattle subset: slim_chkn subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-10T01:40:23Z [Term] id: ID:0000106 name: meat odor def: "characteristics related to the distinctive smell of meat" [CP:Cari Park_Iowa State University curator] subset: slim_cattle subset: slim_pig relationship: part_of ID:0000016 ! meat product quality created_by: caripark creation_date: 2008-11-10T01:40:23Z [Term] id: ID:0000107 name: pH def: "Measurement of muscle pH following slaughter" [CP:Cari Park_Iowa State University curator] subset: slim_cattle subset: slim_chkn subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-10T01:40:23Z [Term] id: ID:0000108 name: stiffening subset: slim_cattle subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-10T01:40:23Z [Term] id: ID:0000109 name: meat texture subset: slim_cattle subset: slim_chkn subset: slim_pig relationship: part_of ID:0000016 ! meat product quality created_by: caripark creation_date: 2008-11-10T01:40:23Z [Term] id: ID:0000110 name: shear force def: "Assessment of meat tenderness based on a measurement of the amount of force (kg) required to shear multiple core samples from a cut of meat" [CP:Cari Park_Iowa State University curator] subset: slim_cattle subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-10T01:40:23Z [Term] id: ID:0000111 name: bone weight def: "weight of one or more of the bones of the skeleton" [CP:Cari Park_Iowa State University curator] subset: slim_cattle subset: slim_pig relationship: part_of MT:0003795 ! bone structure created_by: caripark creation_date: 2008-11-10T01:44:59Z [Term] id: ID:0000112 name: bone yield subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T01:44:59Z [Term] id: ID:0000113 name: carcass dressing subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T01:44:59Z [Term] id: ID:0000114 name: carcass weight def: "weight of a carcass following slaughter and removal of the head, hide, intestinal tract, and internal organs" [CP:Cari Park_Iowa State University curator] subset: slim_cattle subset: slim_chkn subset: slim_pig is_a: MT:0001259 ! body weight created_by: caripark creation_date: 2008-11-10T01:44:59Z [Term] id: ID:0000115 name: carcass yield subset: slim_cattle subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-10T01:44:59Z [Term] id: ID:0000116 name: dressing percentage def: "The percentage of the live animal that ends up as carcass (=hot carcass weight/body weight at slaughter)" [CP:Cari Park_Iowa State University curator] subset: slim_cattle subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-10T01:44:59Z [Term] id: ID:0000117 name: hot carcass weight def: "hot or un-chilled weight of a carcass following slaughter and removal of the head, hide, intestinal tract, and internal organs" [CP:Cari Park_Iowa State University curator] subset: slim_cattle subset: slim_pig is_a: ID:0000114 ! carcass weight created_by: caripark creation_date: 2008-11-10T01:44:59Z [Term] id: ID:0000118 name: vertebra number def: "Number of bone segments constituting the spinal column" [CP:Cari Park_Iowa State University curator] subset: slim_cattle subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-10T01:44:59Z [Term] id: ID:0000119 name: rib bone fat subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T01:44:59Z [Term] id: ID:0000120 name: rib muscle thickness def: "Distance between the latissimus muscle and pleura membrane measured halfway between the rib ends" [CP:Cari Park_Iowa State University curator] subset: slim_cattle relationship: part_of MT:0002280 ! intercostal muscle morphology created_by: caripark creation_date: 2008-11-10T01:44:59Z [Term] id: ID:0000121 name: number of lumbar vertebrae def: "Number of spinal column segments in the loin area, between the ribs and the pelvis" [CP:Cari Park_Iowa State University curator] subset: slim_cattle subset: slim_pig relationship: part_of MT:0000138 ! vertebrae number relationship: part_of MT:0003049 ! lumbar vertebrae morphology created_by: caripark creation_date: 2008-11-10T01:45:36Z [Term] id: ID:0000122 name: number of thoracic vertebrae def: "Number of segments in the middle of the spinal column, which articulate with the ribs" [CP:Cari Park_Iowa State University curator] subset: slim_cattle subset: slim_pig relationship: part_of MT:0000138 ! vertebrae number relationship: part_of MT:0003047 ! thoracic vertebrae morphology created_by: caripark creation_date: 2008-11-10T01:45:36Z [Term] id: ID:0000123 name: USDA yield grade def: "Grade used to classify carcasses based on the expected yield of trimmed, boneless major retail cuts. Calculation is based on external fat thickness, hot carcass weight, kidney, pelvic, and heart fat, and loin muscle area." [CP:Cari Park_Iowa State University curator] subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T01:46:56Z [Term] id: ID:0000124 name: backfat def: "Layer of subcutaneous fat over the back of a pig" [CP:Cari Park_Iowa State University curator] subset: slim_cattle subset: slim_pig synonym: "fatback" EXACT [] is_obsolete: true created_by: caripark creation_date: 2008-11-10T01:50:29Z [Term] id: ID:0000125 name: fat depth subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T01:50:29Z [Term] id: ID:0000126 name: fat thickness def: "the thickness of a layer of adipose tissue" [CP:Cari Park_Iowa State University curator] subset: slim_cattle synonym: "fat depth" EXACT [] is_a: MT:0005452 ! body fat amount created_by: caripark creation_date: 2008-11-10T01:50:29Z [Term] id: ID:0000127 name: fat trim yield subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T01:50:29Z [Term] id: ID:0000128 name: fat weight subset: slim_cattle subset: slim_chkn subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-10T01:50:29Z [Term] id: ID:0000129 name: fat yield subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T01:50:29Z [Term] id: ID:0000130 name: kidney, pelvic, and heart fat weight def: "weight of fat in the body cavity, specifically in the areas of the kidneys, pelvis, and heart" [CP:Cari Park_Iowa State University curator] subset: slim_cattle synonym: "internal fat" EXACT [] is_a: MT:0001781 ! white fat amount created_by: caripark creation_date: 2008-11-10T01:50:29Z [Term] id: ID:0000131 name: marbling def: "visible intramuscular fat" [CP:Cari Park_Iowa State University curator] subset: slim_cattle subset: slim_pig relationship: part_of ID:0000016 ! meat product quality relationship: part_of MT:0000013 ! fat distribution created_by: caripark creation_date: 2008-11-10T01:50:29Z [Term] id: ID:0000132 name: retail product yield def: "yield of trimmed retail cuts obtained from a carcass" [CP:Cari Park_Iowa State University curator] subset: slim_cattle is_a: ID:0000714 ! product weight created_by: caripark creation_date: 2008-11-10T01:50:29Z [Term] id: ID:0000133 name: rib fat weight def: "weight of fat dissected from a wholesale rib cut" [CP:Cari Park_Iowa State University curator] subset: slim_cattle is_a: MT:0001781 ! white fat amount created_by: caripark creation_date: 2008-11-10T01:50:29Z [Term] id: ID:0000134 name: subcutaneous fat def: "layer of fat lying directly beneath the skin" [CP:Cari Park_Iowa State University curator] subset: slim_cattle subset: slim_pig relationship: part_of MT:0000013 ! fat distribution created_by: caripark creation_date: 2008-11-10T01:50:29Z [Term] id: ID:0000135 name: subcutaneous fat thickness def: "thickness of the fat layer directly beneath the skin" [CP:Cari Park_Iowa State University curator] subset: slim_cattle subset: slim_pig is_a: ID:0000126 ! fat thickness relationship: part_of ID:0000134 ! subcutaneous fat created_by: caripark creation_date: 2008-11-10T01:50:57Z [Term] id: ID:0000136 name: adjusted subcutaneous fat thickness between 12th and 13th ribs subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T01:50:57Z [Term] id: ID:0000137 name: back subcutaneous fat thickness subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T01:56:01Z [Term] id: ID:0000138 name: forebelly subcutaneous fat thickness subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T01:56:01Z [Term] id: ID:0000139 name: hind belly subcutaneous fat thickness subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T01:56:01Z [Term] id: ID:0000140 name: loin subcutaneous fat thickness subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T01:56:01Z [Term] id: ID:0000141 name: middle belly subcutaneous fat thickness subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T01:56:01Z [Term] id: ID:0000142 name: shoulder subcutaneous fat thickness def: "Thickness of the subcutaneous fat on the upper portion of the front leg" [CP:Cari Park_Iowa State University curator] subset: slim_cattle subset: slim_pig synonym: "fat depth at shoulder" EXACT [] is_obsolete: true created_by: caripark creation_date: 2008-11-10T01:56:01Z [Term] id: ID:0000143 name: % USDA choice def: "Percentage of animals receiving a USDA quality grade of Choice or higher, based on expected palatability. Grade is based on degree of marbling and animal's physiological age (maturity)" [CP:Cari Park_Iowa State University curator] subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T01:59:03Z [Term] id: ID:0000144 name: double muscling def: "Condition caused by mutation of the myostatin (GDF8) gene, which results in significant skeletal muscle hyperplasia and decreased fat deposition" [CP:Cari Park_Iowa State University curator] subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T01:59:03Z [Term] id: ID:0000145 name: hindquarter muscle weight subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T01:59:03Z [Term] id: ID:0000146 name: longissimus dorsi weight def: "weight of the longissimus dorsi" [CP:Cari Park_Iowa State University curator] subset: slim_cattle subset: slim_pig synonym: "loin weight" EXACT [] synonym: "longissimus muscle weight" EXACT [] is_a: ID:0000706 ! longissimus dorsi morphology is_a: ID:0000712 ! skeletal muscle weight created_by: caripark creation_date: 2008-11-10T01:59:03Z [Term] id: ID:0000147 name: longissimus muscle area is_obsolete: true created_by: caripark creation_date: 2008-11-10T01:59:03Z [Term] id: ID:0000148 name: rib eye area is_obsolete: true created_by: caripark creation_date: 2008-11-10T01:59:03Z [Term] id: ID:0000149 name: rib muscle weight def: "weight of muscle tissue obtained from a wholesale rib cut" [CP:Cari Park_Iowa State University curator] subset: slim_cattle relationship: part_of MT:0002280 ! intercostal muscle morphology created_by: caripark creation_date: 2008-11-10T01:59:03Z [Term] id: ID:0000150 name: Warner-Bratzler shear force def: "Measurement of shear force with precisely defined equipment and sample specifications, including cutting blade thickness, shape, and bevel, and diameter of sample cores" [CP:Cari Park_Iowa State University curator] subset: slim_cattle subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-12-09T01:53:27Z [Term] id: ID:0000151 name: LMA subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T02:40:05Z [Term] id: ID:0000152 name: overall wellness/fitness def: "A measure of the overall healthfulness of an organism, in relation to the frequency with which medical care is required" [CP:Cari Park_Iowa State University curator] subset: slim_cattle synonym: "veterinary treatments" NARROW [] is_a: MT:0005395 ! other trait created_by: caripark creation_date: 2008-11-10T02:40:05Z [Term] id: ID:0000153 name: milk fat subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T02:40:37Z [Term] id: ID:0000154 name: milk protein subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T02:40:37Z [Term] id: ID:0000155 name: milk yield def: "amount of milk produced over a given period of time by a lactating mammal" [CP:Cari Park_Iowa State University curator] subset: slim_cattle is_a: ID:0000701 ! product trait created_by: caripark creation_date: 2008-11-10T02:40:37Z [Term] id: ID:0000156 name: daughter deviation % milk fat def: "Weighted average of the percentage of fat in the milk of a bull's daughters, adjusted for the merit of their dams" [CP:Cari Park_Iowa State University curator] subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T02:43:21Z [Term] id: ID:0000157 name: daughter deviation milk fat yield def: "Weighted average of the amount of fat in the milk of a bull's daughters, adjusted for the merit of their dams" [CP:Cari Park_Iowa State University curator] subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T02:43:21Z [Term] id: ID:0000158 name: milk fat content subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T02:43:21Z [Term] id: ID:0000159 name: milk fat percentage def: "The percentage of a cow's milk that is made up of fat" [CP:Cari Park_Iowa State University curator] subset: slim_cattle synonym: "milk fat content" EXACT [] is_obsolete: true created_by: caripark creation_date: 2008-11-10T02:43:21Z [Term] id: ID:0000160 name: milk fat thickness is_obsolete: true created_by: caripark creation_date: 2008-11-10T02:43:21Z [Term] id: ID:0000161 name: milk fat content def: "amount of fat in milk" [CP:Cari Park_Iowa State University curator] subset: slim_cattle synonym: "milk fat yield" EXACT [] relationship: part_of ID:0000019 ! milk product quality relationship: part_of MT:0004047 ! milk composition created_by: caripark creation_date: 2008-11-10T02:43:21Z [Term] id: ID:0000162 name: daughter deviation % milk protein def: "Weighted average of the percentage of protein in the milk of a bull's daughters, adjusted for the merit of their dams" [CP:Cari Park_Iowa State University curator] subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T02:45:00Z [Term] id: ID:0000163 name: daughter deviation milk protein yield def: "Weighted average of the amount of protein in the milk of a bull's daughters, adjusted for the merit of their dams" [CP:Cari Park_Iowa State University curator] subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T02:45:00Z [Term] id: ID:0000164 name: milk protein percentage def: "Percentage of milk that is made up of protein" [CP:Cari Park_Iowa State University curator] subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T02:45:00Z [Term] id: ID:0000165 name: milk protein content def: "amount of protein in milk" [CP:Cari Park_Iowa State University curator] subset: slim_cattle synonym: "milk protein yield" EXACT [] relationship: part_of ID:0000019 ! milk product quality relationship: part_of MT:0004047 ! milk composition created_by: caripark creation_date: 2008-11-10T02:45:00Z [Term] id: ID:0000166 name: PTA % milk protein def: "Predicted transmitting ability for the percentage of milk made up of protein (takes into account information from both parents and progeny)" [CP:Cari Park_Iowa State University curator] subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T02:45:00Z [Term] id: ID:0000167 name: 305 days milk yield def: "Amount of milk produced by a cow over a 305 day lactation period" [CP:Cari Park_Iowa State University curator] subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T02:46:06Z [Term] id: ID:0000168 name: 3rd year total milk yield def: "Total milk produced by a cow during her third lactation" [CP:Cari Park_Iowa State University curator] subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T02:46:06Z [Term] id: ID:0000169 name: 5th year total milk yield def: "Total milk produced by a cow during her fifth lactation" [CP:Cari Park_Iowa State University curator] subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T02:46:06Z [Term] id: ID:0000170 name: average daily milk yield def: "Average amount of milk produced per day by a cow" [CP:Cari Park_Iowa State University curator] subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T02:46:06Z [Term] id: ID:0000171 name: milk yield-other subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T02:46:06Z [Term] id: ID:0000172 name: follicle stimulating hormone subset: slim_cattle subset: slim_chkn subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-10T02:50:56Z [Term] id: ID:0000173 name: gonadrotropin releasing hormone level def: "Level of the peptide hormone that is produced in the hypothalamus and stimulates the release of follicle stimulating hormone and leutenizing hormone from the anterior pituitary gland" [CP:Cari Park_Iowa State University curator] subset: slim_cattle subset: slim_chkn synonym: "leutenizing hormone releasing hormone level" EXACT [] is_a: MT:0003953 ! hormone level created_by: caripark creation_date: 2008-11-10T02:50:56Z [Term] id: ID:0000174 name: luteinizing hormone subset: slim_cattle subset: slim_chkn subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-10T02:50:56Z [Term] id: ID:0000175 name: progesterone subset: slim_cattle subset: slim_chkn is_obsolete: true created_by: caripark creation_date: 2008-11-10T02:50:56Z [Term] id: ID:0000176 name: prostaglandins subset: slim_cattle subset: slim_chkn is_obsolete: true created_by: caripark creation_date: 2008-11-10T02:50:56Z [Term] id: ID:0000177 name: 56 days non-return rate def: "The proportion of females that must be re-bred within 56 days following insemination." [CP:Cari Park_Iowa State University curator] subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T02:59:38Z [Term] id: ID:0000178 name: 90 days non-return rate def: "The proportion of females that must be re-bred within 90 days following insemination." [CP:Cari Park_Iowa State University curator] subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T02:59:38Z [Term] id: ID:0000179 name: abortions subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T02:59:38Z [Term] id: ID:0000180 name: offspring mortality rate subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T02:59:38Z [Term] id: ID:0000181 name: offspring born alive def: "number of offspring, not including stillborn" [CP:Cari Park_Iowa State University curator] subset: slim_cattle subset: slim_pig synonym: "prenatal survival" EXACT [] synonym: "total number born alive" EXACT [] relationship: part_of MT:0002161 ! fertility/fecundity created_by: caripark creation_date: 2008-11-10T02:59:38Z [Term] id: ID:0000182 name: offspring born alive, % def: "Percentage of offspring born alive (not stillborn)" [CP:Cari Park_Iowa State University curator] subset: slim_cattle subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-10T02:59:38Z [Term] id: ID:0000183 name: offspring weaned def: "number of offspring that survive to weaning" [CP:Cari Park_Iowa State University curator] subset: slim_cattle synonym: "% survival to weaning" EXACT [] relationship: part_of MT:0002161 ! fertility/fecundity created_by: caripark creation_date: 2008-11-10T02:59:38Z [Term] id: ID:0000184 name: delivery ease def: "Tendency of an animal to have more or fewer problems at delivery than average" [CP:Cari Park_Iowa State University curator] subset: slim_cattle relationship: part_of MT:0002907 ! parturition created_by: caripark creation_date: 2008-11-10T02:59:38Z [Term] id: ID:0000185 name: birthing interval is_obsolete: true created_by: caripark creation_date: 2008-11-10T02:59:38Z [Term] id: ID:0000186 name: conception rate subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T02:59:38Z [Term] id: ID:0000187 name: dystocia def: "Difficult labor or delivery" [CP:Cari Park_Iowa State University curator] subset: slim_cattle relationship: part_of MT:0002907 ! parturition created_by: caripark creation_date: 2008-11-10T02:59:38Z [Term] id: ID:0000188 name: early fetal abortion rate subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T02:59:38Z [Term] id: ID:0000189 name: offspring born def: "total number born, including stillborn animals" [CP:Cari Park_Iowa State University curator] subset: slim_cattle subset: slim_pig synonym: "total number born" EXACT [] relationship: part_of MT:0002161 ! fertility/fecundity created_by: caripark creation_date: 2008-12-10T10:22:09Z [Term] id: ID:0000190 name: oestrus intensity def: "the ability of the female to display oestrus" [CP:Cari Park_Iowa State University curator] subset: slim_cattle synonym: "heat intensity" EXACT [] relationship: part_of MT:0001927 ! oestrous cycle (sensu Rodentia) created_by: caripark creation_date: 2008-11-10T02:59:38Z [Term] id: ID:0000191 name: hydrops def: "Accumulation of fluid (edema) in the fetus" [CP:Cari Park_Iowa State University curator] subset: slim_cattle synonym: "hydrops fetalis" EXACT [] is_obsolete: true created_by: caripark creation_date: 2008-11-10T02:59:38Z [Term] id: ID:0000192 name: inseminations per service period subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T02:59:38Z [Term] id: ID:0000193 name: ovulation rate def: "frequency of ovulation, as determined by the number of corpora lutea in the ovary" [CP:Cari Park_Iowa State University curator] subset: slim_cattle subset: slim_pig relationship: part_of MT:0001928 ! ovulation created_by: caripark creation_date: 2008-11-10T02:59:38Z [Term] id: ID:0000194 name: parity of dam def: "Number of times a dam has given birth" [CP:Cari Park_Iowa State University curator] subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T02:59:38Z [Term] id: ID:0000195 name: pregnancy rate def: "measure of the ability of a female to become pregnant" [CP:Cari Park_Iowa State University curator] subset: slim_cattle synonym: "conception rate" EXACT [] synonym: "non-return rate" EXACT [] relationship: part_of MT:0001921 ! fertility created_by: caripark creation_date: 2008-11-10T02:59:38Z [Term] id: ID:0000196 name: non-return rate def: "Proportion of females that must be re-bred following insemination" [CP:Cari Park_Iowa State University curator] subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-12-16T02:50:41Z [Term] id: ID:0000197 name: stillbirth def: "offspring that are either born dead or die within 24 hours of birth" [CP:Cari Park_Iowa State University curator] subset: slim_cattle subset: slim_pig relationship: part_of MT:0002161 ! fertility/fecundity created_by: caripark creation_date: 2008-11-10T02:59:38Z [Term] id: ID:0000198 name: time of conception subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T02:59:38Z [Term] id: ID:0000199 name: twinning rate def: "production of two offspring from a single pregnancy" [CP:Cari Park_Iowa State University curator] subset: slim_cattle relationship: part_of MT:0002161 ! fertility/fecundity created_by: caripark creation_date: 2008-11-10T02:59:38Z [Term] id: ID:0000200 name: type of birth subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T02:59:38Z [Term] id: ID:0000201 name: development time subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T03:00:43Z [Term] id: ID:0000202 name: PTA type def: "An estimate of the genetic superiority for conformation that a bull will transmit to its offspring" [CP:Cari Park_Iowa State University curator] subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T03:00:43Z [Term] id: ID:0000203 name: female measurements subset: slim_cattle subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-10T03:01:22Z [Term] id: ID:0000204 name: male measurements subset: slim_cattle subset: slim_chkn subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-10T03:01:22Z [Term] id: ID:0000205 name: teat length def: "average length of the teats" [CP:Cari Park_Iowa State University curator] subset: slim_cattle is_a: MT:0006078 ! nipple morphology created_by: caripark creation_date: 2008-11-10T03:02:18Z [Term] id: ID:0000206 name: teat number def: "total number of teats/nipples on a female" [CP:Cari Park_Iowa State University curator] subset: slim_cattle subset: slim_pig synonym: "nipple number" EXACT [] is_a: MT:0006078 ! nipple morphology created_by: caripark creation_date: 2008-11-10T03:02:18Z [Term] id: ID:0000207 name: accessory sperm def: "additional spermatazoa retained in the zona pellucida of the oocyte after penetration of the first sperm during fertilization" [CP:Cari Park_Iowa State University curator] subset: slim_cattle subset: slim_chkn is_a: MT:0005410 ! fertilization created_by: caripark creation_date: 2008-11-10T03:03:07Z [Term] id: ID:0000208 name: retrograde sperm def: "sperm that migrate back into the vagina following intrauterine insemination" [CP:Cari Park_Iowa State University curator] subset: slim_cattle relationship: part_of MT:0005410 ! fertilization created_by: caripark creation_date: 2008-11-10T03:03:07Z [Term] id: ID:0000209 name: retrograde sperm loss subset: slim_cattle subset: slim_chkn is_obsolete: true created_by: caripark creation_date: 2008-11-10T03:03:07Z [Term] id: ID:0000210 name: scrotal circumference def: "Circumference of the external sac of skin that encloses the testes" [ISBN:0-683-40008-8 Stedman's Medical Dictionary\, 27th edition] subset: slim_cattle relationship: part_of MT:0002669 ! scrotum morphology created_by: caripark creation_date: 2008-11-10T03:03:07Z [Term] id: ID:0000211 name: sex drive subset: slim_cattle subset: slim_chkn is_obsolete: true created_by: caripark creation_date: 2008-11-10T03:03:07Z [Term] id: ID:0000212 name: sperm activity score subset: slim_cattle subset: slim_chkn is_obsolete: true created_by: caripark creation_date: 2008-11-10T03:03:07Z [Term] id: ID:0000213 name: sperm counts subset: slim_cattle subset: slim_chkn is_obsolete: true created_by: caripark creation_date: 2008-11-10T03:03:07Z [Term] id: ID:0000214 name: sperm quality subset: slim_cattle subset: slim_chkn is_obsolete: true created_by: caripark creation_date: 2008-11-10T03:03:07Z [Term] id: ID:0000215 name: % survival to weaning is_obsolete: true created_by: caripark creation_date: 2008-11-10T03:04:56Z [Term] id: ID:0000216 name: birth assistance def: "necessity of assistance during delivery of offspring" [CP:Cari Park_Iowa State University curator] subset: slim_cattle subset: slim_pig relationship: part_of MT:0002907 ! parturition created_by: caripark creation_date: 2008-11-10T03:04:56Z [Term] id: ID:0000217 name: age at first breeding subset: slim_cattle subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-10T03:04:56Z [Term] id: ID:0000218 name: age at puberty subset: slim_cattle subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-10T03:04:56Z [Term] id: ID:0000219 name: structural soundness def: "Soundness of legs, feet, penis, and prepuce" [CP:Cari Park_Iowa State University curator] subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2008-11-10T03:04:56Z [Term] id: ID:0000220 name: abdominal fat weight def: "weight of the fat lining the abdominal cavity and surrounding the kidneys" [CP:Cari Park_Iowa State University curator] subset: slim_pig synonym: "leaf fat weight" EXACT [] is_a: MT:0001781 ! white fat amount created_by: caripark creation_date: 2008-11-10T03:41:26Z [Term] id: ID:0000221 name: body weight (5 weeks) def: "Body weight at 5 weeks of age" [CP:Cari Park_Iowa State University curator] subset: slim_chkn is_obsolete: true created_by: caripark creation_date: 2008-11-10T03:42:21Z [Term] id: ID:0000222 name: body weight is_obsolete: true created_by: caripark creation_date: 2008-11-10T03:43:30Z [Term] id: ID:0000223 name: pectoral muscle weight def: "combined weight of the pectoralis major and pectoralis minor" [CP:Cari Park_Iowa State University curator] subset: slim_chkn synonym: "breast muscle weight" EXACT [] is_a: ID:0000712 ! skeletal muscle weight relationship: part_of MT:0003346 ! pectoral muscle morphology created_by: caripark creation_date: 2008-11-10T03:45:54Z [Term] id: ID:0000224 name: bursa of Fabricius weight def: "Weight of an epithelial outgrowth of the cloaca in birds where B-lymphocyte maturation occurs" [CP:Cari Park_Iowa State University curator, MeSH:A10.549.175] subset: slim_chkn relationship: part_of ID:0000668 ! bursa of Fabricius size created_by: caripark creation_date: 2008-11-10T03:45:54Z [Term] id: ID:0000225 name: drumstick weight def: "weight of the hindlimb of a bird, consisting of the tibia and the surrounding meat and skin" [CP:Cari Park_Iowa State University curator] subset: slim_chkn is_a: ID:0000714 ! product weight relationship: part_of ID:0000689 ! hindlimb weight created_by: caripark creation_date: 2008-11-10T03:45:54Z [Term] id: ID:0000226 name: gizzard weight def: "Weight of the secondary, muscular stomach in some animals used for grinding up food" [CP:Cari Park_Iowa State University curator] subset: slim_chkn relationship: part_of ID:0000667 ! gizzard morphology created_by: caripark creation_date: 2008-11-10T03:45:54Z [Term] id: ID:0000227 name: heart weight def: "Weight of the organ that pumps blood throughout the body" [CP:Cari Park_Iowa State University curator] subset: slim_chkn subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-10T03:45:54Z [Term] id: ID:0000228 name: intestine length def: "Length of the digestive tract" [CP:Cari Park_Iowa State University curator] subset: slim_chkn subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-10T03:45:54Z [Term] id: ID:0000229 name: liver weight def: "Weight of the liver removed from a carcass" [CP:Cari Park_Iowa State University curator] subset: slim_chkn subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-10T03:45:54Z [Term] id: ID:0000230 name: lung weight def: "Weight of the lung removed from a carcass" [CP:Cari Park_Iowa State University curator] subset: slim_chkn is_obsolete: true created_by: caripark creation_date: 2008-11-10T03:45:54Z [Term] id: ID:0000231 name: shank weight def: "Weight of the part of the leg between the claw and the first joint" [CP:Cari Park_Iowa State University curator] subset: slim_chkn is_obsolete: true created_by: caripark creation_date: 2008-11-10T03:45:54Z [Term] id: ID:0000232 name: skin fat weight def: "Weight of skin plus attached fat obtained from the breast, leg, and thigh of a chicken" [CP:Cari Park_Iowa State University curator] subset: slim_chkn is_obsolete: true created_by: caripark creation_date: 2008-11-10T03:45:54Z [Term] id: ID:0000233 name: spleen weight def: "Weight of the spleen" [CP:Cari Park_Iowa State University curator] subset: slim_chkn relationship: part_of MT:0002224 ! spleen size created_by: caripark creation_date: 2008-11-10T03:45:54Z [Term] id: ID:0000234 name: thigh muscle weight def: "weight of the muscle tissue surrounding the femur of the chicken" [CP:Cari Park_Iowa State University curator] subset: slim_chkn is_a: ID:0000712 ! skeletal muscle weight relationship: part_of ID:0000235 ! thigh weight created_by: caripark creation_date: 2008-11-10T03:45:54Z [Term] id: ID:0000235 name: thigh weight def: "weight of the part of the chicken consisting of the femur and surrounding meat and skin." [CP:Cari Park_Iowa State University curator] subset: slim_chkn is_a: ID:0000714 ! product weight relationship: part_of ID:0000689 ! hindlimb weight created_by: caripark creation_date: 2008-11-10T03:45:54Z [Term] id: ID:0000236 name: weight of the front half of the carcass def: "weight of the front section of the chicken carcass that results when the whole bird is cut perpendicular to the spine at the ilium, just above the femur; it consists of the entire breast, the adjacent back and ribs, and both wings." [CP:Cari Park_Iowa State University curator] subset: slim_chkn relationship: part_of ID:0000114 ! carcass weight created_by: caripark creation_date: 2008-11-10T03:45:54Z [Term] id: ID:0000237 name: wing weight def: "weight of the forelimb of a bird, consisting of the humerus, radius, ulna, and metacarpus, and all associated muscle and skin" [CP:Cari Park_Iowa State University curator] subset: slim_chkn is_a: ID:0000687 ! forelimb weight is_a: ID:0000714 ! product weight created_by: caripark creation_date: 2008-11-10T03:45:54Z [Term] id: ID:0000238 name: feathering def: "initial appearance and growth of feathers on young birds" [CP:Cari Park_Iowa State University curator] subset: slim_chkn relationship: part_of ID:0000664 ! feather morphology created_by: caripark creation_date: 2008-11-10T03:46:33Z [Term] id: ID:0000239 name: drumstick muscle weight def: "weight of the muscle tissue surrounding the tibia of the chicken" [CP:Cari Park_Iowa State University curator] subset: slim_chkn is_a: ID:0000712 ! skeletal muscle weight relationship: part_of ID:0000225 ! drumstick weight created_by: caripark creation_date: 2008-11-10T03:56:45Z [Term] id: ID:0000240 name: contrafreeloading def: "To search for food, even though food is readily available" [CP:Cari Park_Iowa State University curator] subset: slim_chkn is_a: MT:0001432 ! food preference created_by: caripark creation_date: 2008-11-11T09:38:27Z [Term] id: ID:0000241 name: fear-related behavior def: "behavior that occurs in response to perceived danger" [CP:Cari Park_Iowa State University curator] subset: slim_chkn is_a: MT:0002572 ! emotion/affect behavior created_by: caripark creation_date: 2008-11-11T09:38:27Z [Term] id: ID:0000242 name: feather pecking def: "Gentle, forceful, or aggressive pecking of the other birds in an enclosure" [CP:Cari Park_Iowa State University curator] subset: slim_chkn is_a: MT:0002557 ! social/conspecific interaction created_by: caripark creation_date: 2008-11-11T09:38:27Z [Term] id: ID:0000243 name: receiving feather pecking def: "A bird is the recipient of gentle, forceful, or aggressive pecking by the other birds in an enclosure" [CP:Cari Park_Iowa State University curator] subset: slim_chkn is_a: MT:0002557 ! social/conspecific interaction created_by: caripark creation_date: 2008-11-11T09:38:27Z [Term] id: ID:0000244 name: social tendency def: "Tendency to choose freely available food or food in combination with social stimuli in a maze test with several options" [CP:Cari Park_Iowa State University curator] subset: slim_chkn is_a: MT:0002557 ! social/conspecific interaction created_by: caripark creation_date: 2008-11-11T09:38:27Z [Term] id: ID:0000245 name: antibody response to x subset: slim_chkn is_obsolete: true created_by: caripark creation_date: 2008-11-11T09:47:36Z [Term] id: ID:0000246 name: bacteria count in cecum def: "bacterial count (cfu) in the outpouching(s) of the large intestine below the entrance of the small intestine" [CP:Cari Park_Iowa State University curator, MeSH:A03.556.124.526.209] subset: slim_chkn is_a: ID:0000665 ! bacteria count created_by: caripark creation_date: 2008-11-11T09:47:36Z [Term] id: ID:0000247 name: bacteria count in cloaca def: "bacterial count (cfu) in the common cavity into which the intestinal, genital, and urinary tracts open in some species" [ISBN:9780618701728] subset: slim_chkn is_a: ID:0000665 ! bacteria count created_by: caripark creation_date: 2008-11-11T09:47:36Z [Term] id: ID:0000248 name: Marek's disease-related traits subset: slim_chkn is_obsolete: true created_by: caripark creation_date: 2008-11-11T09:47:36Z [Term] id: ID:0000249 name: oocyst shedding def: "presence in the feces of the encapsulated zygote stage of certain protozoans" [CP:Cari Park_Iowa State University curator] subset: slim_chkn is_a: ID:0000675 ! response to parasitic infection created_by: caripark creation_date: 2008-11-11T09:47:36Z [Term] id: ID:0000250 name: spleen bacterial burden after challenging with y subset: slim_chkn is_obsolete: true created_by: caripark creation_date: 2008-11-11T09:47:36Z [Term] id: ID:0000251 name: time to achieve maximum antibody response subset: slim_chkn is_obsolete: true created_by: caripark creation_date: 2008-11-11T09:47:36Z [Term] id: ID:0000252 name: total mortality def: "Ability of an individual to survive until the end of an experiment" [CP:Cari Park_Iowa State University curator] subset: slim_chkn is_obsolete: true created_by: caripark creation_date: 2008-11-11T09:48:43Z [Term] id: ID:0000253 name: egg albumen height def: "height of the inner thick albumen (egg white) when an egg is broken onto a flat surface" [CP:Cari Park_Iowa State University curator] subset: slim_chkn relationship: part_of ID:0000695 ! egg albumen morphology created_by: caripark creation_date: 2008-11-11T09:55:05Z [Term] id: ID:0000254 name: egg albumen weight def: "weight of the egg white (weight of the entire egg minus weights of the yolk and shell)" [CP:Cari Park_Iowa State University curator] subset: slim_chkn relationship: part_of ID:0000577 ! egg weight relationship: part_of ID:0000695 ! egg albumen morphology created_by: caripark creation_date: 2008-11-11T09:55:05Z [Term] id: ID:0000255 name: egg shell color def: "objective measurements of egg shell color" [CP:Cari Park_Iowa State University curator] subset: slim_chkn relationship: part_of ID:0000696 ! egg shell morphology created_by: caripark creation_date: 2008-11-11T09:55:05Z [Term] id: ID:0000256 name: egg shell percentage def: "Percentage of the mass of an egg comprised of shell ([shell weight/total weight] x100)" [CP:Cari Park_Iowa State University curator] subset: slim_chkn is_obsolete: true created_by: caripark creation_date: 2008-11-11T09:55:05Z [Term] id: ID:0000257 name: egg shell shape def: "the ratio of the width of the egg at its widest point to its length at the longest point" [CP:Cari Park_Iowa State University curator] subset: slim_chkn relationship: part_of ID:0000696 ! egg shell morphology created_by: caripark creation_date: 2008-11-11T09:55:05Z [Term] id: ID:0000258 name: egg shell strength def: "a measure of the force required to fracture the shell of an egg" [CP:Cari Park_Iowa State University curator] subset: slim_chkn relationship: part_of ID:0000698 ! egg shell physiology created_by: caripark creation_date: 2008-11-11T09:55:05Z [Term] id: ID:0000259 name: egg shell thickness def: "thickness of the exterior shell of an egg" [CP:Cari Park_Iowa State University curator] subset: slim_chkn relationship: part_of ID:0000696 ! egg shell morphology created_by: caripark creation_date: 2008-11-11T09:55:05Z [Term] id: ID:0000260 name: egg shell weight def: "weight of the rinsed and dried egg shell" [CP:Cari Park_Iowa State University curator] subset: slim_chkn relationship: part_of ID:0000577 ! egg weight relationship: part_of ID:0000696 ! egg shell morphology created_by: caripark creation_date: 2008-11-11T09:55:05Z [Term] id: ID:0000261 name: Haugh unit def: "A measure of the internal quality of an egg, taking into account its weight and the height of the albumen (egg white) surrounding the yolk" [CP:Cari Park_Iowa State University curator] subset: slim_chkn is_obsolete: true created_by: caripark creation_date: 2008-11-11T09:55:05Z [Term] id: ID:0000262 name: gravitational constant is_obsolete: true created_by: caripark creation_date: 2008-11-11T09:55:05Z [Term] id: ID:0000263 name: long length of egg def: "length of egg from end to end" [CP:Cari Park_Iowa State University curator] subset: slim_chkn relationship: part_of ID:0000015 ! egg product quality created_by: caripark creation_date: 2008-11-11T09:55:05Z [Term] id: ID:0000264 name: short length of egg def: "diameter of egg (shorter dimension)" [CP:Cari Park_Iowa State University curator] subset: slim_chkn relationship: part_of ID:0000015 ! egg product quality created_by: caripark creation_date: 2008-11-11T09:55:05Z [Term] id: ID:0000265 name: egg specific gravity def: "ratio of the weight of an egg to the weight of an equal volume of water; an indicator of eggshell thickness" [CP:Cari Park_Iowa State University curator] subset: slim_chkn relationship: part_of ID:0000015 ! egg product quality created_by: caripark creation_date: 2008-11-11T09:55:05Z [Term] id: ID:0000266 name: egg yolk weight def: "weight of the yolk of an egg" [CP:Cari Park_Iowa State University curator] subset: slim_chkn relationship: part_of ID:0000577 ! egg weight relationship: part_of ID:0000697 ! egg yolk morphology created_by: caripark creation_date: 2008-11-11T09:55:05Z [Term] id: ID:0000267 name: yolk index def: "The height of the yolk of a broken egg divided by the yolk diameter" [CP:Cari Park_Iowa State University curator] subset: slim_chkn is_obsolete: true created_by: caripark creation_date: 2008-11-11T09:55:05Z [Term] id: ID:0000268 name: color of the breast subset: slim_chkn is_obsolete: true created_by: caripark creation_date: 2008-11-11T10:15:31Z [Term] id: ID:0000269 name: white meat weight def: "combined weight of the breast (pectoralis major and pectoralis minor) and wing meat; back muscle weight may or may not be included" [CP:Cari Park_Iowa State University curator] subset: slim_chkn is_a: ID:0000714 ! product weight created_by: caripark creation_date: 2008-11-11T10:15:31Z [Term] id: ID:0000270 name: egg shell redness def: "chromatic component of egg shell color from green to red (a*)" [CP:Cari Park_Iowa State University curator] subset: slim_chkn relationship: part_of ID:0000255 ! egg shell color created_by: caripark creation_date: 2008-11-11T10:15:31Z [Term] id: ID:0000271 name: egg shell lightness def: "luminance or lightness component of egg shell color (L*)" [CP:Cari Park_Iowa State University curator] subset: slim_chkn relationship: part_of ID:0000255 ! egg shell color created_by: caripark creation_date: 2008-11-11T10:15:31Z [Term] id: ID:0000272 name: egg shell yellowness def: "chromatic component of egg shell color from blue to yellow (b*)" [CP:Cari Park_Iowa State University curator] subset: slim_chkn relationship: part_of ID:0000255 ! egg shell color created_by: caripark creation_date: 2008-11-11T10:15:31Z [Term] id: ID:0000273 name: total blood cell count def: "Number of red and white blood cells" [CP:Cari Park_Iowa State University curator] subset: slim_chkn is_a: MT:0002429 ! blood cell morphology/development created_by: caripark creation_date: 2008-11-11T10:27:07Z [Term] id: ID:0000274 name: bone mineral content def: "Mineral content of a bone, as determined by x-ray densitometric scanning" [CP:Cari Park_Iowa State University curator] subset: slim_chkn relationship: part_of MT:0002896 ! bone mineralization created_by: caripark creation_date: 2008-11-11T10:32:08Z [Term] id: ID:0000275 name: bone mineral density def: "The mineral content of a bone, adjusted for the bone's size" [CP:Cari Park_Iowa State University curator] subset: slim_chkn is_obsolete: true created_by: caripark creation_date: 2008-11-11T10:32:08Z [Term] id: ID:0000276 name: humerus area def: "area of the humerus, calculated based on the length and width determined by x-ray densitometric scanning" [CP:Cari Park_Iowa State University curator] relationship: part_of MT:0005296 ! humerus morphology created_by: caripark creation_date: 2008-11-11T10:32:08Z [Term] id: ID:0000277 name: humerus bone mineral content def: "Mineral content of the humerus, as determined by x-ray densitometric scanning" [CP:Cari Park_Iowa State University curator] subset: slim_chkn relationship: part_of ID:0000274 ! bone mineral content created_by: caripark creation_date: 2008-11-11T10:32:08Z [Term] id: ID:0000278 name: humerus bone density def: "The mineral content of the humerus, adjusted for the bone's size" [CP:Cari Park_Iowa State University curator] subset: slim_chkn synonym: "humerus bone mineral density" EXACT [] relationship: part_of MT:0005007 ! bone density created_by: caripark creation_date: 2008-11-11T10:32:08Z [Term] id: ID:0000279 name: humerus length def: "Length of the humerus from end to end" [CP:Cari Park_Iowa State University curator] is_obsolete: true created_by: caripark creation_date: 2008-11-11T10:32:08Z [Term] id: ID:0000280 name: humerus width def: "width of the humerus halfway between the ends" [CP:Cari Park_Iowa State University curator] relationship: part_of MT:0005296 ! humerus morphology created_by: caripark creation_date: 2008-11-11T10:32:08Z [Term] id: ID:0000281 name: tibia area def: "Area of the tibia, calculated based on the length and width determined by x-ray densitometric scanning" [CP:Cari Park_Iowa State University curator] subset: slim_chkn relationship: part_of MT:0000558 ! tibia morphology created_by: caripark creation_date: 2008-11-11T10:32:08Z [Term] id: ID:0000282 name: tibia bone mineral content def: "Mineral content of the tibia, as determined by x-ray densitometric scanning" [CP:Cari Park_Iowa State University curator] subset: slim_chkn relationship: part_of ID:0000274 ! bone mineral content created_by: caripark creation_date: 2008-11-11T10:32:08Z [Term] id: ID:0000283 name: tibia bone density def: "The mineral content of the tibia, adjusted for the bone's size" [CP:Cari Park_Iowa State University curator] subset: slim_chkn synonym: "tibia bone mineral density" EXACT [] relationship: part_of MT:0005007 ! bone density created_by: caripark creation_date: 2008-11-11T10:32:08Z [Term] id: ID:0000284 name: tibia breaking force def: "The amount of force required to break the tibia in the middle, while it is supported on both ends" [CP:Cari Park_Iowa State University curator] subset: slim_chkn relationship: part_of MT:0001542 ! bone strength created_by: caripark creation_date: 2008-11-11T10:32:08Z [Term] id: ID:0000285 name: tibia length def: "Length of the tibia from end to end" [CP:Cari Park_Iowa State University curator] subset: slim_chkn is_obsolete: true created_by: caripark creation_date: 2008-11-11T10:32:08Z [Term] id: ID:0000286 name: tibia modulus of elasticity def: "A measure of the tibia's ability to return to its original shape after force is applied in the center, while the bone is supported on the ends (stress:strain ratio)" [CP:Cari Park_Iowa State University curator] subset: slim_chkn relationship: part_of MT:0001542 ! bone strength created_by: caripark creation_date: 2008-11-11T10:32:08Z [Term] id: ID:0000287 name: tibia strain def: "An indicator of the amount of bending the tibia undergoes when force is applied in the center, and the bone is supported at both ends (change in length per unit length of bone)" [CP:Cari Park_Iowa State University curator] subset: slim_chkn relationship: part_of MT:0001542 ! bone strength created_by: caripark creation_date: 2008-11-11T10:32:08Z [Term] id: ID:0000288 name: tibia stress def: "Force applied to the tibia per unit area" [CP:Cari Park_Iowa State University curator] subset: slim_chkn relationship: part_of MT:0001542 ! bone strength created_by: caripark creation_date: 2008-11-11T10:32:08Z [Term] id: ID:0000289 name: tibia width def: "Width of the tibia halfway between the ends" [CP:Cari Park_Iowa State University curator] subset: slim_chkn relationship: part_of MT:0000558 ! tibia morphology created_by: caripark creation_date: 2008-11-11T10:32:08Z [Term] id: ID:0000290 name: age at first egg def: "Age at which a bird lays its first egg" [CP:Cari Park_Iowa State University curator] subset: slim_chkn is_obsolete: true created_by: caripark creation_date: 2008-11-11T10:43:29Z [Term] id: ID:0000291 name: annual egg production def: "Eggs laid by a bird in a year" [CP:Cari Park_Iowa State University curator] subset: slim_chkn is_obsolete: true created_by: caripark creation_date: 2008-11-11T10:43:29Z [Term] id: ID:0000292 name: egg production rate def: "number of eggs laid by a bird divided by the number of days over which they are produced" [CP:Cari Park_Iowa State University curator] subset: slim_chkn synonym: "eggs laid per day" EXACT [] is_a: ID:0000701 ! product trait created_by: caripark creation_date: 2008-11-11T10:43:29Z [Term] id: ID:0000293 name: egg weight is_obsolete: true created_by: caripark creation_date: 2008-11-11T10:43:29Z [Term] id: ID:0000294 name: number of eggs produced def: "number of eggs produced over a given period of time" [CP:Cari Park_Iowa State University curator] subset: slim_chkn is_a: ID:0000701 ! product trait created_by: caripark creation_date: 2008-11-11T10:43:29Z [Term] id: ID:0000295 name: sum of the eggs laid by a bird is_obsolete: true created_by: caripark creation_date: 2008-11-11T10:43:29Z [Term] id: ID:0000296 name: body weight (final) def: "Animal's body weight at the end of a defined test period" [CP:Cari Park_Iowa State University curator] subset: slim_chkn synonym: "test end body weight" EXACT [] is_obsolete: true created_by: caripark creation_date: 2008-11-11T10:43:29Z [Term] id: ID:0000297 name: feed efficiency def: "Ratio of body weight gain to amount of feed consumed" [CP:Cari Park_Iowa State University curator] subset: slim_chkn is_obsolete: true created_by: caripark creation_date: 2008-11-11T10:46:34Z [Term] id: ID:0000298 name: conformation score subset: slim_chkn is_obsolete: true created_by: caripark creation_date: 2008-11-11T10:50:00Z [Term] id: ID:0000299 name: weight loss during transport def: "Difference in body weight before and after transport" [CP:Cari Park_Iowa State University curator] subset: slim_chkn is_a: MT:0001263 ! weight loss created_by: caripark creation_date: 2008-11-11T10:51:51Z [Term] id: ID:0000300 name: average daily gain (10-22 weeks) def: "Average daily change in body weight from 10 to 22 weeks of age" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T12:42:29Z [Term] id: ID:0000301 name: average daily gain (18-26 weeks) def: "Average daily change in body weight from 18 to 26 weeks of age" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T12:42:29Z [Term] id: ID:0000302 name: average daily gain (3-5 weeks) def: "Average daily change in body weight from 3 to 5 weeks of age" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T12:42:29Z [Term] id: ID:0000303 name: average daily gain (3-10 weeks) def: "Average daily change in body weight from 3 to 10 weeks of age" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T12:42:29Z [Term] id: ID:0000304 name: average daily gain (4-13 weeks) def: "Average daily change in body weight from 4 to 13 weeks of age" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T12:42:29Z [Term] id: ID:0000305 name: average daily gain (5-7 weeks) def: "Average daily change in body weight from 5 to 7 weeks of age" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T12:42:29Z [Term] id: ID:0000306 name: average daily gain (60-160 days) def: "Average daily change in body weight from 60 to 160 days of age" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T12:42:29Z [Term] id: ID:0000307 name: average daily gain (7-9 weeks) def: "Average daily change in body weight from 7 to 9 weeks of age" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T12:42:29Z [Term] id: ID:0000308 name: average daily gain (8-18 weeks) def: "Average daily change in body weight from 8 to 18 weeks of age" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T12:42:29Z [Term] id: ID:0000309 name: average daily gain (birth to 3 weeks) def: "Average daily change in body weight from birth to 3 weeks of age" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T12:42:29Z [Term] id: ID:0000310 name: average daily gain (birth to 60 days) def: "Average daily change in body weight from birth to 60 days of age" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T12:42:29Z [Term] id: ID:0000311 name: average daily gain (25-90 kg) def: "Average daily change in body weight between the weights of 25 and 90 kg" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T12:42:29Z [Term] id: ID:0000312 name: average daily gain (35-55 kg) def: "Average daily change in body weight between the weights of 35 and 55 kg" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T12:42:29Z [Term] id: ID:0000313 name: average daily gain (55-80 kg) def: "Average daily change in body weight between the weights of 55 and 80 kg" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T12:42:29Z [Term] id: ID:0000314 name: average daily gain (birth to 30 kg) def: "Average daily change in body weight from birth to 30 kg" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T12:42:29Z [Term] id: ID:0000315 name: average daily gain (birth to 70 kg) def: "Average daily change in body weight from birth to 70 kg" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T12:42:29Z [Term] id: ID:0000316 name: average daily gain (birth to end of test) def: "Average daily change in body weight from birth to the end of a test period" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T12:42:29Z [Term] id: ID:0000317 name: average daily gain (entire life) def: "Average daily change in body weight from birth to slaughter" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T12:42:29Z [Term] id: ID:0000318 name: average daily gain on test def: "Average daily change in body weight during a test period" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T12:42:29Z [Term] id: ID:0000319 name: average daily gain on weaning def: "Average daily change in body weight from birth to weaning" [CP:Cari Park_Iowa State University curator] subset: slim_cattle subset: slim_pig synonym: "pre-weaning average daily gain" EXACT [] is_obsolete: true created_by: caripark creation_date: 2008-11-11T12:42:29Z [Term] id: ID:0000320 name: average daily gain (weaning to 25 kg) def: "Average daily change in body weight from weaning to 25 kg" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T12:42:29Z [Term] id: ID:0000321 name: average daily gain (weaning to 55 kg) def: "Average daily change in body weight from weaning to 55 kg" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T12:42:29Z [Term] id: ID:0000322 name: age at slaughter def: "Age of an animal at the time of slaughter" [CP:Cari Park_Iowa State University curator] subset: slim_pig relationship: part_of MT:0001661 ! life span created_by: caripark creation_date: 2008-11-11T12:43:08Z [Term] id: ID:0000323 name: body weight (10 weeks) def: "Body weight at 10 weeks of age" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T12:48:27Z [Term] id: ID:0000324 name: body weight (13 weeks) def: "Body weight at 13 weeks of age" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T12:48:27Z [Term] id: ID:0000325 name: body weight (16 days) def: "Body weight at 16 days of age" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T12:48:27Z [Term] id: ID:0000326 name: body weight (17 weeks) def: "Body weight at 17 weeks of age" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T12:48:27Z [Term] id: ID:0000327 name: body weight (21 days) def: "Body weight at 21 days of age" [CP:Cari Park_Iowa State University curator] is_obsolete: true created_by: caripark creation_date: 2008-11-11T12:48:27Z [Term] id: ID:0000328 name: body weight (22 weeks) def: "Body weight at 22 weeks of age" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T12:48:27Z [Term] id: ID:0000329 name: body weight (25 weeks) def: "Body weight at 25 weeks of age" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T12:48:27Z [Term] id: ID:0000330 name: body weight (26 weeks) def: "Body weight at 26 weeks of age" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T12:48:27Z [Term] id: ID:0000331 name: body weight (3 weeks) def: "Body weight at 3 weeks of age" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T12:48:27Z [Term] id: ID:0000332 name: body weight (30 days) def: "Body weight at 30 days of age" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T12:48:27Z [Term] id: ID:0000333 name: body weight (35 days) def: "Body weight at 35 days of age" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T12:48:27Z [Term] id: ID:0000334 name: body weight (4 weeks) def: "Body weight at 4 weeks of age" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T12:48:27Z [Term] id: ID:0000335 name: body weight (60 days) def: "Body weight at 60 days of age" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T12:48:27Z [Term] id: ID:0000336 name: body weight (8 weeks) def: "Body weight at 8 weeks of age" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T12:48:27Z [Term] id: ID:0000337 name: body weight (birth) def: "Body weight at birth" [CP:Cari Park_Iowa State University curator] subset: slim_cattle subset: slim_pig synonym: "birth weight" EXACT [] is_obsolete: true created_by: caripark creation_date: 2008-11-11T12:48:27Z [Term] id: ID:0000338 name: body weight (slaughter) def: "Body weight at slaughter" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T12:48:27Z [Term] id: ID:0000339 name: body weight (weaning) def: "Body weight at weaning" [CP:Cari Park_Iowa State University curator] subset: slim_cattle subset: slim_pig synonym: "weaning weight" EXACT [] is_obsolete: true created_by: caripark creation_date: 2008-11-11T12:48:27Z [Term] id: ID:0000340 name: longevity subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T12:52:40Z [Term] id: ID:0000341 name: basal circulating adrenocorticotropin level def: "Level of pituitary adrenocorticotropic hormone in the blood in the absence of an external intervention" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_a: MT:0002664 ! circulating adrenocorticotropin level created_by: caripark creation_date: 2008-11-11T12:58:57Z [Term] id: ID:0000342 name: post-stress ACTH level def: "Level of pituitary adrenocorticotropic hormone in the blood at the end of a stress test" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T12:58:57Z [Term] id: ID:0000343 name: basal circulating cortisol level def: "Level of cortisol in the blood in the absence of external intervention" [CP:Cari Park_Iowa State University curator] subset: slim_pig synonym: "basal circulating hydrocortisone level" EXACT [] is_a: ID:0000670 ! circulating cortisol level created_by: caripark creation_date: 2008-11-11T12:58:57Z [Term] id: ID:0000344 name: basal circulating glucose level def: "Level of glucose in the blood in the absence of external intervention" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_a: MT:0000188 ! circulating glucose level created_by: caripark creation_date: 2008-11-11T12:58:57Z [Term] id: ID:0000345 name: exploration def: "Time spent rooting or sniffing the sides or floor of the arena during a stress test" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T12:58:57Z [Term] id: ID:0000346 name: locomotion def: "The extent of movement during a stress test, measured by the number of sections (marked on the floor) the animal enters in an unfamiliar area" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T12:58:57Z [Term] id: ID:0000347 name: induced circulating glucose level def: "Level of glucose in the blood in response to an external intervention" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_a: MT:0000188 ! circulating glucose level created_by: caripark creation_date: 2008-11-11T12:58:57Z [Term] id: ID:0000348 name: glucose level variations def: "Difference between post-stress and basal levels of glucose in the blood" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T12:58:57Z [Term] id: ID:0000349 name: neuroendocrine response def: "Alterations in the levels of adrenocorticotropic hormone, glucose, and cortisol in response to stress" [CP:Cari Park_Iowa State University curator] subset: slim_pig relationship: part_of MT:0002164 ! gland physiology created_by: caripark creation_date: 2008-11-11T12:58:57Z [Term] id: ID:0000350 name: induced circulating cortisol level def: "Level of cortisol in the blood in response to external intervention" [CP:Cari Park_Iowa State University curator] subset: slim_pig synonym: "induced circulating hydrocortisone level" EXACT [] is_a: ID:0000670 ! circulating cortisol level created_by: caripark creation_date: 2008-11-11T12:58:57Z [Term] id: ID:0000351 name: black vs. white coat color subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T01:01:13Z [Term] id: ID:0000352 name: white coat color is_obsolete: true created_by: caripark creation_date: 2008-11-11T01:01:13Z [Term] id: ID:0000353 name: spotted coat def: "presence of spots on an animal's coat" [CP:Cari Park_Iowa State University curator] subset: slim_cattle is_a: MT:0002075 ! coat color created_by: caripark creation_date: 2008-11-11T01:01:13Z [Term] id: ID:0000354 name: rhinitis is_obsolete: true created_by: caripark creation_date: 2008-11-11T01:10:14Z [Term] id: ID:0000355 name: scrotal hernia def: "An inguinal hernia that has passed into the scrotum" [CP:Cari Park_Iowa State University curator] subset: slim_pig relationship: part_of MT:0002669 ! scrotum morphology created_by: caripark creation_date: 2008-11-11T01:10:14Z [Term] id: ID:0000356 name: swelling of joints is_obsolete: true created_by: caripark creation_date: 2008-11-11T01:10:14Z [Term] id: ID:0000357 name: joint abnormalities subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T01:10:14Z [Term] id: ID:0000358 name: joint lesions subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T01:10:14Z [Term] id: ID:0000359 name: osteochondrosis def: "A class of joint diseases characterized by interruption of a bone's blood supply and bone necrosis, followed by bone regrowth" [CP:Cari Park_Iowa State University curator] subset: slim_pig relationship: part_of MT:0003795 ! bone structure created_by: caripark creation_date: 2008-11-11T01:10:14Z [Term] id: ID:0000360 name: body length def: "Distance along an animal's top line from between the shoulder blades to the end of the rump" [CP:Cari Park_Iowa State University curator] is_obsolete: true created_by: caripark creation_date: 2008-11-11T01:13:23Z [Term] id: ID:0000361 name: circumference of cannon bone def: "circumference of the metacarpal or metatarsal bone, between the knee or hock and the fetlock" [CP:Cari Park_Iowa State University curator] subset: slim_pig relationship: part_of MT:0000550 ! forelimb morphology relationship: part_of MT:0000556 ! hindlimb morphology relationship: part_of MT:0003072 ! metatarsal bone morphology relationship: part_of MT:0003073 ! metacarpal bone morphology created_by: caripark creation_date: 2008-11-11T01:13:23Z [Term] id: ID:0000362 name: length of claws (front inside) subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T01:13:23Z [Term] id: ID:0000363 name: length of claws (front outside) subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T01:13:23Z [Term] id: ID:0000364 name: length of claws (hind inside) subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T01:13:23Z [Term] id: ID:0000365 name: length of claws (hind outside) subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T01:13:23Z [Term] id: ID:0000366 name: feet and legs score subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T01:13:23Z [Term] id: ID:0000367 name: feet score (front) subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T01:13:23Z [Term] id: ID:0000368 name: feet score (hind) subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T01:13:23Z [Term] id: ID:0000369 name: femur dimensions def: "measurements relating to the size of the long bone of the thigh" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_a: MT:0000559 ! femur morphology created_by: caripark creation_date: 2008-11-11T01:13:23Z [Term] id: ID:0000370 name: hair (amount) subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T01:13:23Z [Term] id: ID:0000371 name: height is_obsolete: true created_by: caripark creation_date: 2008-11-11T01:13:23Z [Term] id: ID:0000372 name: leg length subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T01:13:23Z [Term] id: ID:0000373 name: leg pastern (front) subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T01:13:23Z [Term] id: ID:0000374 name: leg pastern (hind) subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T01:13:23Z [Term] id: ID:0000375 name: leg score (front) subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T01:13:23Z [Term] id: ID:0000376 name: leg score (hind) subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T01:13:23Z [Term] id: ID:0000377 name: leg set view subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T01:13:23Z [Term] id: ID:0000378 name: leg torsion (front) subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T01:13:23Z [Term] id: ID:0000379 name: leg torsion (hind) subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T01:13:23Z [Term] id: ID:0000380 name: leg angularity (front) subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T01:13:23Z [Term] id: ID:0000381 name: leg angularity (hind) subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T01:13:23Z [Term] id: ID:0000382 name: lob ear subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T01:13:23Z [Term] id: ID:0000383 name: nose score subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T01:13:23Z [Term] id: ID:0000384 name: vertebrae distance def: "Distance from first thoracic to last lumber vertebra" [CP:Cari Park_Iowa State University curator] subset: slim_pig relationship: part_of MT:0000137 ! vertebrae morphology created_by: caripark creation_date: 2008-11-11T01:14:37Z [Term] id: ID:0000385 name: total vertebrae number def: "Total number of bone segments constituting the spinal column" [CP:Cari Park_Iowa State University curator] subset: slim_cattle subset: slim_pig relationship: part_of MT:0000138 ! vertebrae number created_by: caripark creation_date: 2008-11-11T01:16:14Z [Term] id: ID:0000386 name: induced circulating IgG level def: "Level of serum immunoglobulin G in response to an external intervention" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_a: MT:0001805 ! circulating IgG level created_by: caripark creation_date: 2008-11-11T01:40:12Z [Term] id: ID:0000387 name: anti-O149 E. coli IgG level response def: "Change in serum levels of E. coli O149 IgG following immunization with E. coli antigens" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T01:40:12Z [Term] id: ID:0000388 name: anti-O149 E. coli IgG levels def: "Level of serum IgG to E. coli O149 antigen" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T01:40:12Z [Term] id: ID:0000389 name: susceptibility to E. coli K88 infection def: "Likelihood that an organism will develop ill effects from infection with Escherichia coli expressing K88 antigen" [CP:Cari Park_Iowa State University curator] subset: slim_pig synonym: "resistance to E. coli K88 infection" EXACT [] is_obsolete: true created_by: caripark creation_date: 2008-11-11T01:40:12Z [Term] id: ID:0000390 name: susceptibility to pseudorabies viral infection def: "Likelihood that an organism will develop ill effects from infection with pseudorabies virus (suid herpesvirus-1, porcine herpesvirus 1)" [CP:Cari Park_Iowa State University curator] subset: slim_pig synonym: "resistance to pseudorabies viral infection" EXACT [] is_obsolete: true created_by: caripark creation_date: 2008-11-11T01:40:12Z [Term] id: ID:0000391 name: susceptibility to E. coli F18 infection def: "Susceptibility to infection by F18-positive E. coli due to the expression of ECF18R alleles in the small intestine" [CP:Cari Park_Iowa State University curator] subset: slim_pig synonym: "small intestinal E. coli F18 receptor" EXACT [] is_obsolete: true created_by: caripark creation_date: 2008-11-11T01:40:12Z [Term] id: ID:0000392 name: conA-induced lymphocyte proliferation def: "proliferation of lymphocytes upon stimulation with concanavalin A, a lectin isolated from the jack bean, Canavalia ensiformis" [CP:Cari Park_Iowa State University curator, MeSH:D12.776.503.499.500 "National Library of Medicine - Medical Subject Headings"] subset: slim_pig is_a: ID:0000393 ! mitogen-induced lymphocyte proliferation created_by: caripark creation_date: 2008-11-11T01:50:35Z [Term] id: ID:0000393 name: mitogen-induced lymphocyte proliferation def: "proliferation of lymphocytes upon stimulation with a protein that induces cell division" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_a: ID:0000661 ! lymphocyte proliferation created_by: caripark creation_date: 2008-11-11T01:50:35Z [Term] id: ID:0000394 name: pokeweed mitogen (PWM)-induced lymphocyte proliferation def: "proliferation of lymphocytes upon stimulation with pokeweed mitogen, a lectin isolated from the roots of Phytolacca americana" [CP:Cari Park_Iowa State University curator, MeSH:D12.776.503.499.875 "National Library of Medicine - Medical Subject Headings"] subset: slim_pig is_a: ID:0000393 ! mitogen-induced lymphocyte proliferation created_by: caripark creation_date: 2008-11-11T01:50:35Z [Term] id: ID:0000395 name: post-stress mitogen-induced IL-2 activity subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T01:50:35Z [Term] id: ID:0000396 name: pre-/post-vaccination levels of IgG to K88 antigen subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T01:50:35Z [Term] id: ID:0000397 name: specific IgG response to E. coli O149 antigen subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T01:50:35Z [Term] id: ID:0000398 name: spontaneous lymphocyte proliferation def: "unstimulated proliferation of lymphocytes" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_a: ID:0000661 ! lymphocyte proliferation created_by: caripark creation_date: 2008-11-11T01:50:35Z [Term] id: ID:0000399 name: stress-induced leukocyte proliferation subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T01:50:35Z [Term] id: ID:0000400 name: stress-induced neutrophil number alteration subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T01:50:35Z [Term] id: ID:0000401 name: muscle androstenone level def: "amount of the testicular steroid androstenone detected in muscle via ELISA or HPLC" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_a: MT:0002106 ! muscle physiology created_by: caripark creation_date: 2008-11-11T02:26:46Z [Term] id: ID:0000402 name: fecal bacteria count def: "bacterial count (cfu) in feces" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_a: ID:0000665 ! bacteria count created_by: caripark creation_date: 2008-11-11T01:54:41Z [Term] id: ID:0000403 name: salmonella count in feces (day 7 post-infection) subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T01:54:41Z [Term] id: ID:0000404 name: bacteria count in liver def: "bacterial count (cfu) in liver" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_a: ID:0000665 ! bacteria count created_by: caripark creation_date: 2008-11-11T01:54:41Z [Term] id: ID:0000405 name: bacteria count in spleen def: "bacterial count (cfu) in spleen" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_a: ID:0000665 ! bacteria count created_by: caripark creation_date: 2008-11-11T01:54:41Z [Term] id: ID:0000406 name: cold carcass weight def: "weight of a carcass that has been chilled overnight following slaughter and removal of the head, hide, intestinal tract, and internal organs" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_a: ID:0000114 ! carcass weight created_by: caripark creation_date: 2008-11-11T01:57:31Z [Term] id: ID:0000407 name: belly percentage def: "Weight of the cut of meat from the underside of the pig divided by the weight of the carcass" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T02:01:04Z [Term] id: ID:0000408 name: belly weight def: "weight of the cut of meat obtained from the underside of the pig" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_a: ID:0000714 ! product weight created_by: caripark creation_date: 2008-11-11T02:01:04Z [Term] id: ID:0000409 name: body mass index is_obsolete: true created_by: caripark creation_date: 2008-11-11T02:01:04Z [Term] id: ID:0000410 name: bone percent subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T02:01:04Z [Term] id: ID:0000411 name: carcass length def: "length of the carcass following removal of the head; typically measured between the first or second cervical vertebra or the first rib and the pelvis" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_a: MT:0001256 ! body length created_by: caripark creation_date: 2008-11-11T02:01:04Z [Term] id: ID:0000412 name: carcass thickness subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T02:01:04Z [Term] id: ID:0000413 name: glycogen content def: "Concentration in muscle of the glucose polysaccharide used for short-term energy storage" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T02:26:46Z [Term] id: ID:0000414 name: diaphragm weight def: "Weight of the muscle that separates the thoracic and abdominal cavities" [CP:Cari Park_Iowa State University curator] subset: slim_pig relationship: part_of MT:0002279 ! diaphragm morphology created_by: caripark creation_date: 2008-11-11T02:01:04Z [Term] id: ID:0000415 name: glycolytic potential def: "measure of the available glycogen stores in tissue = 2 x ([glycogen]+[glucose]+[glucose-6-phosphate])+[lactate]" [CP:Cari Park_Iowa State University curator] subset: slim_pig relationship: part_of ID:0000694 ! muscle glycogen homeostasis relationship: part_of MT:0005438 ! glycogen homeostasis created_by: caripark creation_date: 2008-11-11T02:26:46Z [Term] id: ID:0000416 name: estimated carcass lean content subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T02:01:04Z [Term] id: ID:0000417 name: eye muscle depth is_obsolete: true created_by: caripark creation_date: 2008-11-11T02:01:04Z [Term] id: ID:0000418 name: fat-cut percentage subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T02:01:04Z [Term] id: ID:0000419 name: total foot weight def: "Weight of the front feet separated from the carcass at the level of the carpal bones, and the hind feet removed at the tibio-tarsal joint" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_a: ID:0000686 ! paw/hand/foot/hoof weight created_by: caripark creation_date: 2008-11-11T02:01:04Z [Term] id: ID:0000420 name: head weight def: "Weight of the head, separated from the carcass at the second cervical vertebra" [CP:Cari Park_Iowa State University curator] subset: slim_pig relationship: part_of MT:0000002 ! head size created_by: caripark creation_date: 2008-11-11T02:01:04Z [Term] id: ID:0000421 name: small intestine length def: "Length of the upper portion of the digestive tract, between the stomach and the large intestine" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_a: MT:0000496 ! small intestine morphology created_by: caripark creation_date: 2008-11-11T02:01:04Z [Term] id: ID:0000422 name: shoulder weight def: "weight of the untrimmed cut of meat from the upper portion of the front leg of the pig" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_a: ID:0000714 ! product weight relationship: part_of ID:0000687 ! forelimb weight created_by: caripark creation_date: 2008-11-11T02:01:04Z [Term] id: ID:0000423 name: skin percentage subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T02:01:04Z [Term] id: ID:0000424 name: skin thickness def: "Thickness of skin on the back, at the midpoint of body length" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T02:01:04Z [Term] id: ID:0000425 name: skin weight def: "weight of the membranous protective covering of the body; may include closely associated fat" [CP:Cari Park_Iowa State University curator] subset: slim_chkn subset: slim_pig relationship: part_of MT:0002060 ! skin morphology created_by: caripark creation_date: 2008-11-11T02:01:04Z [Term] id: ID:0000426 name: weight of trimmed wholesale product def: "weight of four major wholesale cuts of the pig (ham, loin, Boston butt, and picnic shoulder), trimmed of fat" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_a: ID:0000714 ! product weight created_by: caripark creation_date: 2008-11-11T02:01:04Z [Term] id: ID:0000427 name: trimmed wholesale product/live weight def: "Weight of four major wholesale cuts of the pig (ham, loin, Boston butt, and picnic shoulder) trimmed of fat and adjusted to a constant live weight" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T02:01:04Z [Term] id: ID:0000428 name: carcass fat-free weight is_obsolete: true created_by: caripark creation_date: 2008-11-11T02:01:17Z [Term] id: ID:0000429 name: muscle lactate level def: "concentration in muscle of the compound produced from pyruvate by lactate dehydrogenase" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_a: MT:0002106 ! muscle physiology created_by: caripark creation_date: 2008-11-11T02:26:46Z [Term] id: ID:0000430 name: muscle cholesterol level def: "amount of cholesterol present in the total lipid extracted from a muscle" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_a: MT:0003947 ! cholesterol level relationship: part_of ID:0000479 ! muscle lipid level created_by: caripark creation_date: 2008-11-11T02:26:46Z [Term] id: ID:0000431 name: muscle indole level def: "amount of a tryptophan degradation product detected in muscle via HPLC" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_a: MT:0002106 ! muscle physiology created_by: caripark creation_date: 2008-11-11T02:26:46Z [Term] id: ID:0000432 name: muscle water content def: "amount of moisture in a muscle sample, determined by the difference in weight before and after oven drying" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_a: MT:0000676 ! water content is_a: MT:0002106 ! muscle physiology created_by: caripark creation_date: 2008-11-11T02:26:46Z [Term] id: ID:0000433 name: muscle protein level def: "total protein content of muscle" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_a: MT:0002106 ! muscle physiology created_by: caripark creation_date: 2008-11-11T02:26:46Z [Term] id: ID:0000434 name: muscle skatole level def: "amount of a tryptophan degradation product detected in muscle via HPLC or colorimetric assay" [CP:Cari Park_Iowa State University curator] subset: slim_pig synonym: "3-methyl indole concentration" EXACT [] is_a: MT:0002106 ! muscle physiology created_by: caripark creation_date: 2008-11-11T02:26:46Z [Term] id: ID:0000435 name: muscle conductivity def: "ability of muscle to conduct electrical current" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_a: MT:0002106 ! muscle physiology created_by: caripark creation_date: 2008-11-11T02:27:18Z [Term] id: ID:0000436 name: skeletal muscle conductivity def: "ability of skeletal muscle to conduct electrical current" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_a: ID:0000435 ! muscle conductivity created_by: caripark creation_date: 2008-11-11T02:29:54Z [Term] id: ID:0000437 name: conductivity (45 min post-mortem) def: "Electrical conductivity of muscle 45 minutes post-mortem" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T02:29:54Z [Term] id: ID:0000438 name: creatine phosphokinase test def: "Test for the enzyme that catalyzes the conversion of creatine to phosphocreatine. Elevated levels are an indication of muscle damage." [CP:Cari Park_Iowa State University curator] synonym: "creatine kinase test" EXACT [] is_obsolete: true created_by: caripark creation_date: 2008-11-11T02:33:29Z [Term] id: ID:0000439 name: 7-octadecenoic acid percentage is_obsolete: true created_by: caripark creation_date: 2008-11-11T02:37:42Z [Term] id: ID:0000440 name: fatty acid carbon chain length def: "Average number of carbon atoms in the fatty acids in a sample, determined by gas chromatography" [CP:Cari Park_Iowa State University curator] subset: slim_pig relationship: part_of MT:0005666 ! adipose tissue physiology created_by: caripark creation_date: 2008-11-11T02:37:42Z [Term] id: ID:0000441 name: double-bond index def: "Sum of the percentage of fatty acids in a fat sample with any number of double bonds, multiplied by the number of double bonds, with the total divided by 100" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T02:37:42Z [Term] id: ID:0000442 name: eicosadienoic acid percentage is_obsolete: true created_by: caripark creation_date: 2008-11-11T02:37:42Z [Term] id: ID:0000443 name: eicosenoic acid percentage is_obsolete: true created_by: caripark creation_date: 2008-11-11T02:37:42Z [Term] id: ID:0000444 name: fat androstenone level def: "Amount of the testicular steroid androstenone detected in fat samples via ELISA" [CP:Cari Park_Iowa State University curator] subset: slim_pig relationship: part_of MT:0005666 ! adipose tissue physiology created_by: caripark creation_date: 2008-11-11T02:37:42Z [Term] id: ID:0000445 name: heptadecanoic acid percentage is_obsolete: true created_by: caripark creation_date: 2008-11-11T02:37:42Z [Term] id: ID:0000446 name: linoleic acid percentage is_obsolete: true created_by: caripark creation_date: 2008-11-11T02:37:42Z [Term] id: ID:0000447 name: linolenic acid percentage is_obsolete: true created_by: caripark creation_date: 2008-11-11T02:37:42Z [Term] id: ID:0000448 name: myristic acid percentage is_obsolete: true created_by: caripark creation_date: 2008-11-11T02:37:42Z [Term] id: ID:0000449 name: oleic acid percentage is_obsolete: true created_by: caripark creation_date: 2008-11-11T02:37:42Z [Term] id: ID:0000450 name: palmitic acid percentage is_obsolete: true created_by: caripark creation_date: 2008-11-11T02:37:42Z [Term] id: ID:0000451 name: palmitoleic acid percentage is_obsolete: true created_by: caripark creation_date: 2008-11-11T02:37:42Z [Term] id: ID:0000452 name: peroxidability index def: "Calculated from fatty acid percentage of a fat sample: [(% monoenoic x 0.025) + (% dienoic) + (% trienoic x 2) + (% tetraenoic x 4) + (% pentaenoic x 6) + (% hexaenoic x8)]" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T02:37:42Z [Term] id: ID:0000453 name: stearic acid percentage is_obsolete: true created_by: caripark creation_date: 2008-11-11T02:37:42Z [Term] id: ID:0000454 name: unsaturated index def: "Equal to double bond index/percentage of saturated fatty acids in a fat sample" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T02:37:42Z [Term] id: ID:0000455 name: fat androstenone level (100 days of age) def: "Amount of the testicular steroid androstenone detected in backfat biopsies via ELISA (100 days of age)" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T02:38:46Z [Term] id: ID:0000456 name: fat androstenone level (120 days of age) def: "Amount of the testicular steroid androstenone detected in backfat biopsies via ELISA (120 days of age)" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T02:38:46Z [Term] id: ID:0000457 name: fat androstenone level (140 days of age) def: "Amount of the testicular steroid androstenone detected in backfat biopsies via ELISA (140 days of age)" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T02:38:46Z [Term] id: ID:0000458 name: fat androstenone level (160 days of age) def: "Amount of the testicular steroid androstenone detected in backfat biopsies via ELISA (160 days of age)" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T02:38:46Z [Term] id: ID:0000459 name: abdominal fat subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T02:41:11Z [Term] id: ID:0000460 name: fat area def: "Area of fat on M. Lattisimus Dorsi between the 13th and 14th ribs" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_a: MT:0000003 ! adipose tissue morphology created_by: caripark creation_date: 2008-11-11T02:47:13Z [Term] id: ID:0000461 name: fat cuts subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T02:47:13Z [Term] id: ID:0000462 name: fat percentage in carcass subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T02:47:13Z [Term] id: ID:0000463 name: fat ratio (percentage) subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T02:47:13Z [Term] id: ID:0000464 name: fat-to-meat ratio subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T02:47:13Z [Term] id: ID:0000465 name: intermuscular fat weight def: "weight of fat present between the muscles" [CP:Cari Park_Iowa State University curator] subset: slim_pig synonym: "seam fat weight" EXACT [] is_a: MT:0001781 ! white fat amount created_by: caripark creation_date: 2008-11-11T02:47:13Z [Term] id: ID:0000466 name: internal fat ratio subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T02:47:13Z [Term] id: ID:0000467 name: intestinal fat percent subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T02:47:13Z [Term] id: ID:0000468 name: intestinal fat weight def: "weight of the fat associated with the small intestine" [CP:Cari Park_Iowa State University curator] subset: slim_pig synonym: "caul fat" EXACT [] is_a: MT:0001781 ! white fat amount created_by: caripark creation_date: 2008-11-11T02:47:13Z [Term] id: ID:0000469 name: backfat depth def: "Depth of subcutaneous fat (including skin) at a point on the animal's back" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T02:58:47Z [Term] id: ID:0000470 name: leaf fat percentage def: "Weight of the fat lining the abdominal cavity and surrounding the kidneys, expressed as a percentage of total carcass weight" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T02:47:13Z [Term] id: ID:0000471 name: leaf fat weight def: "Weight of the fat lining the abdominal cavity and surrounding the kidneys" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T02:47:13Z [Term] id: ID:0000472 name: subcutaneous fat weight def: "weight of the fat layer directly under the skin" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_a: MT:0001781 ! white fat amount relationship: part_of ID:0000134 ! subcutaneous fat created_by: caripark creation_date: 2008-11-11T02:48:24Z [Term] id: ID:0000473 name: backfat + leaf fat percentage def: "Sum of subcutaneous backfat and internal fat, expressed as a percentage of total carcass weight" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T02:47:13Z [Term] id: ID:0000474 name: residual fatty acids subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T02:47:13Z [Term] id: ID:0000475 name: shoulder external fat weight def: "Weight of the fat trimmed from the cut of meat from the upper portion of the front leg" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T02:47:13Z [Term] id: ID:0000476 name: shoulder fat depth def: "Depth of the subcutaneous fat on the upper portion of the front leg" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T02:47:13Z [Term] id: ID:0000477 name: side fat subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T02:47:13Z [Term] id: ID:0000478 name: total fatty acid level subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T02:47:13Z [Term] id: ID:0000479 name: muscle lipid level def: "total lipid content of a muscle" [CP:Cari Park_Iowa State University curator] subset: slim_pig synonym: "total lipid" EXACT [] is_a: MT:0002106 ! muscle physiology relationship: part_of ID:0000016 ! meat product quality created_by: caripark creation_date: 2008-11-11T02:47:13Z [Term] id: ID:0000480 name: intramuscular fat weight def: "weight of the fat present within skeletal muscle, determined through either petroleum-ether or detergent extraction or near-infrared transmission analysis" [CP:Cari Park_Iowa State University curator] subset: slim_cattle subset: slim_pig is_a: MT:0001781 ! white fat amount relationship: part_of ID:0000016 ! meat product quality created_by: caripark creation_date: 2008-11-11T02:54:44Z [Term] id: ID:0000481 name: intramuscular fat percentage def: "Mass of fat present within skeletal muscle, determined through either petroleum-ether or detergent extraction or near-infrared transmission analysis, expressed as a percentage of muscle weight" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T02:54:44Z [Term] id: ID:0000482 name: backfat percentage def: "Weight of subcutaneous fat along the back of the pig, expressed as a percentage of total carcass weight" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T02:58:47Z [Term] id: ID:0000483 name: backfat weight def: "Weight of subcutaneous fat along the back of the pig" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T02:58:47Z [Term] id: ID:0000484 name: backfat (40 kg live weight) subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T03:14:09Z [Term] id: ID:0000485 name: backfat (60 kg live weight) subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T03:14:09Z [Term] id: ID:0000486 name: average backfat thickness subset: slim_pig synonym: "loin fat depth" EXACT [] is_obsolete: true created_by: caripark creation_date: 2008-11-11T03:14:09Z [Term] id: ID:0000487 name: backfat above muscle dorsi subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T03:14:09Z [Term] id: ID:0000488 name: backfat at first lumbar subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T03:14:09Z [Term] id: ID:0000489 name: backfat at first rib def: "Subcutaneous fat thickness on the back at the position of the first rib" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T03:14:09Z [Term] id: ID:0000490 name: backfat at last lumbar def: "Subcutaneous fat thickness on the back at the position of the last lumbar vertebra" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T03:14:09Z [Term] id: ID:0000491 name: backfat at last rib def: "Subcutaneous fat thickness on the back at the position of the last rib" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T03:14:09Z [Term] id: ID:0000492 name: backfat at neck subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T03:14:09Z [Term] id: ID:0000493 name: backfat at P2 position subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T03:14:09Z [Term] id: ID:0000494 name: backfat at rump subset: slim_pig synonym: "rear backfat" EXACT [] is_obsolete: true created_by: caripark creation_date: 2008-11-11T03:14:09Z [Term] id: ID:0000495 name: backfat at shoulder subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T03:14:09Z [Term] id: ID:0000496 name: backfat at tenth rib def: "Subcutaneous fat thickness on the back at the position of the tenth rib" [CP:Cari Park_Iowa State University curator] subset: slim_pig synonym: "loin fat depth" RELATED [] is_obsolete: true created_by: caripark creation_date: 2008-11-11T03:14:09Z [Term] id: ID:0000497 name: backfat between 3rd and 4th rib subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T03:14:09Z [Term] id: ID:0000498 name: backfat between 6th and 7th rib subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T03:14:09Z [Term] id: ID:0000499 name: backfat between 3rd and 4th lumbar subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T03:14:09Z [Term] id: ID:0000500 name: backfat at max. mus. depth subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T03:14:09Z [Term] id: ID:0000501 name: backfat on longissimus dorsi at 12th/14th rib subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T03:14:09Z [Term] id: ID:0000502 name: backfat on longissimus dorsi at 13th/14th rib subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T03:14:09Z [Term] id: ID:0000503 name: backfat middle is_obsolete: true created_by: caripark creation_date: 2008-11-11T03:14:09Z [Term] id: ID:0000504 name: backfat side def: "Subcutaneous fat thickness on the animal's side at the interface of the 13th and 14th ribs" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T03:14:09Z [Term] id: ID:0000505 name: backfat 3 vertebrae beneath last rib subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T03:14:09Z [Term] id: ID:0000506 name: backfat at first rib (14 weeks of age) subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T03:18:14Z [Term] id: ID:0000507 name: backfat at mid-back def: "Subcutaneous fat thickness on the back at the mid-point of the body" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T03:14:09Z [Term] id: ID:0000508 name: FOM backfat depth def: "Loin fat depth measured by Fat-O-Meater" [CP:Cari Park_Iowa State University curator] subset: slim_pig synonym: "Average backfat" RELATED [] synonym: "Loin fat depth" RELATED [] is_obsolete: true created_by: caripark creation_date: 2008-11-11T03:14:09Z [Term] id: ID:0000509 name: loin fat depth is_obsolete: true created_by: caripark creation_date: 2008-11-11T03:14:09Z [Term] id: ID:0000510 name: backfat at last rib (14 weeks of age) subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T03:15:39Z [Term] id: ID:0000511 name: backfat at last rib (26 weeks of age) subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T03:15:39Z [Term] id: ID:0000512 name: backfat at first rib (26 weeks of age) subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T03:18:14Z [Term] id: ID:0000513 name: backfat at last lumbar (14 weeks of age) subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T03:19:01Z [Term] id: ID:0000514 name: backfat at last lumbar (26 weeks of age) subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T03:19:01Z [Term] id: ID:0000515 name: backfat at tenth rib (13 weeks of age) subset: slim_pig synonym: "loin fat depth" RELATED [] is_obsolete: true created_by: caripark creation_date: 2008-11-11T03:20:15Z [Term] id: ID:0000516 name: backfat at tenth rib (17 weeks of age) subset: slim_pig synonym: "loin fat depth" RELATED [] is_obsolete: true created_by: caripark creation_date: 2008-11-11T03:20:15Z [Term] id: ID:0000517 name: backfat at tenth rib (22 weeks of age) subset: slim_pig synonym: "loin fat depth" RELATED [] is_obsolete: true created_by: caripark creation_date: 2008-11-11T03:20:15Z [Term] id: ID:0000518 name: 7-octadecenoic acid level def: "Amount of a monounsaturated fatty acid (C18H34O2), with a carbon-carbon double bond in the n-7 position, present in a sample of fat" [CP:Cari Park_Iowa State University curator] subset: slim_pig synonym: "7-octadecenoic acid percentage" EXACT [] is_a: MT:0005285 ! unsaturated fatty acid level created_by: caripark creation_date: 2008-11-11T03:26:41Z [Term] id: ID:0000519 name: eicosadienoic acid level def: "Amount of an unsaturated fatty acid (C20H36O2), with two carbon-carbon double bonds, present in a sample of fat" [CP:Cari Park_Iowa State University curator] subset: slim_pig synonym: "eicosadienoic acid percentage" EXACT [] is_a: MT:0005285 ! unsaturated fatty acid level created_by: caripark creation_date: 2008-11-11T03:26:41Z [Term] id: ID:0000520 name: eicosenoic acid level def: "Amount of a monounsaturated fatty acid (C20H38O2), with a carbon-carbon double bond in the n-9 position, present in a sample of fat" [CP:Cari Park_Iowa State University curator] subset: slim_pig synonym: "eicosenoic acid percentage" EXACT [] is_a: MT:0005285 ! unsaturated fatty acid level created_by: caripark creation_date: 2008-11-11T03:26:41Z [Term] id: ID:0000521 name: heptadecanoic acid level def: "Amount of a saturated fatty acid (C17H34O2) present in a sample of fat" [CP:Cari Park_Iowa State University curator] subset: slim_pig synonym: "fatty acid C17:0" EXACT [] synonym: "heptadecanoic acid percentage" EXACT [] synonym: "margaric acid" EXACT [] is_a: MT:0005286 ! saturated fatty acid level created_by: caripark creation_date: 2008-11-11T03:26:41Z [Term] id: ID:0000522 name: linoleic acid level def: "Amount of an omega-6 unsaturated fatty acid (C18H32O2), with two carbon-carbon double bonds, present in a sample of fat" [CP:Cari Park_Iowa State University curator] subset: slim_pig synonym: "linoleic acid percentage" EXACT [] is_a: MT:0005285 ! unsaturated fatty acid level created_by: caripark creation_date: 2008-11-11T03:26:41Z [Term] id: ID:0000523 name: linolenic acid level def: "Amount of an omega-3, polyunsaturated fatty acid (C18H30O2), with three carbon-carbon double bonds, present in a sample of fat" [CP:Cari Park_Iowa State University curator] subset: slim_pig synonym: "alpha-linolenic acid percentage" EXACT [] synonym: "linolenic acid percentage" EXACT [] is_a: MT:0005285 ! unsaturated fatty acid level created_by: caripark creation_date: 2008-11-11T03:26:41Z [Term] id: ID:0000524 name: myristic acid level def: "Amount of a saturated fatty acid (C14H28O2), present in a sample of fat" [CP:Cari Park_Iowa State University curator] subset: slim_pig synonym: "myristic acid percentage" EXACT [] synonym: "tetradecanoic acid percentage" EXACT [] is_a: MT:0005286 ! saturated fatty acid level created_by: caripark creation_date: 2008-11-11T03:26:41Z [Term] id: ID:0000525 name: oleic acid level def: "Amount of a monounsaturated, omega-9 fatty acid (C18H34O2), present in a sample of fat" [CP:Cari Park_Iowa State University curator] subset: slim_pig synonym: "oleic acid percentage" EXACT [] is_a: MT:0005285 ! unsaturated fatty acid level created_by: caripark creation_date: 2008-11-11T03:26:41Z [Term] id: ID:0000526 name: palmitic acid level def: "Amount of a saturated fatty acid (C16H32O2) present in a sample of fat" [CP:Cari Park_Iowa State University curator] subset: slim_pig synonym: "hexadecanoic acid percentage" EXACT [] synonym: "palmitic acid percentage" EXACT [] is_a: MT:0005286 ! saturated fatty acid level created_by: caripark creation_date: 2008-11-11T03:26:41Z [Term] id: ID:0000527 name: palmitoleic acid level def: "Amount of an omega-7, monounsaturated fatty acid (C16H30O2) present in a sample of fat" [CP:Cari Park_Iowa State University curator] subset: slim_pig synonym: "palmitoleic acid percentage" EXACT [] is_a: MT:0005285 ! unsaturated fatty acid level created_by: caripark creation_date: 2008-11-11T03:26:41Z [Term] id: ID:0000528 name: stearic acid level def: "Amount of a saturated fatty acid (C18H36O2) present in a sample of fat" [CP:Cari Park_Iowa State University curator] subset: slim_pig synonym: "stearic acid percentage" EXACT [] is_a: MT:0005286 ! saturated fatty acid level created_by: caripark creation_date: 2008-11-11T03:26:41Z [Term] id: ID:0000529 name: androstenone flavor in meat def: "perceived urine-like flavor in the meat or fat of some uncastrated male pigs" [CP:Cari Park_Iowa State University curator] subset: slim_pig relationship: part_of ID:0000102 ! meat flavor created_by: caripark creation_date: 2008-11-11T03:29:36Z [Term] id: ID:0000530 name: intensity taste is_obsolete: true created_by: caripark creation_date: 2008-11-11T03:29:36Z [Term] id: ID:0000531 name: pork flavor in fat subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T03:29:36Z [Term] id: ID:0000532 name: pork flavor in lean subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T03:29:36Z [Term] id: ID:0000533 name: skatole flavor in meat def: "perceived manure-like flavor in the meat or fat of some uncastrated male pigs" [CP:Cari Park_Iowa State University curator] subset: slim_pig relationship: part_of ID:0000102 ! meat flavor created_by: caripark creation_date: 2008-11-11T03:29:36Z [Term] id: ID:0000534 name: subjective abnormal flavor in fat is_obsolete: true created_by: caripark creation_date: 2008-11-11T03:29:36Z [Term] id: ID:0000535 name: subjective abnormal flavor in lean is_obsolete: true created_by: caripark creation_date: 2008-11-11T03:29:36Z [Term] id: ID:0000536 name: boar flavor in fat subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T03:29:36Z [Term] id: ID:0000537 name: boar flavor in lean subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T03:29:36Z [Term] id: ID:0000538 name: subjective chew score is_obsolete: true created_by: caripark creation_date: 2008-11-11T03:29:36Z [Term] id: ID:0000539 name: meat flavor intensity def: "scoring scale ranging from no flavor to intense flavor" [CP:Cari Park_Iowa State University curator] subset: slim_pig synonym: "flavor score" EXACT [] synonym: "taste intensity" EXACT [] relationship: part_of ID:0000102 ! meat flavor created_by: caripark creation_date: 2008-11-11T03:29:36Z [Term] id: ID:0000540 name: subjective juiciness score def: "Evaluation of the amount of liquid released by a piece of meat during chewing" [CP:Cari Park_Iowa State University curator] is_obsolete: true created_by: caripark creation_date: 2008-11-11T03:29:36Z [Term] id: ID:0000541 name: off-flavor score def: "Detection of any flavor that cannot be described as \"normal\". Examples include sour, bitter, earthy, and metallic." [CP:Cari Park_Iowa State University curator] subset: slim_pig synonym: "abnormal flavor" EXACT [] is_obsolete: true created_by: caripark creation_date: 2008-11-11T03:29:36Z [Term] id: ID:0000542 name: pork flavor in fat subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T03:29:36Z [Term] id: ID:0000543 name: pork flavor in lean subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T03:29:36Z [Term] id: ID:0000544 name: subjective tenderness score is_obsolete: true created_by: caripark creation_date: 2008-11-11T03:29:36Z [Term] id: ID:0000545 name: meat color - chroma def: "a measure of meat color intensity or saturation, =(a^2+b^2)^0.5" [CP:Cari Park_Iowa State University curator] subset: slim_pig synonym: "saturation index" EXACT [] relationship: part_of ID:0000104 ! meat color created_by: caripark creation_date: 2008-11-11T03:33:19Z [Term] id: ID:0000546 name: meat color a def: "objective measure of meat redness, measured by a colorimeter" [CP:Cari Park_Iowa State University curator] subset: slim_pig relationship: part_of ID:0000104 ! meat color created_by: caripark creation_date: 2008-11-11T03:33:19Z [Term] id: ID:0000547 name: meat color b def: "objective measure of meat yellowness, measured by a colorimeter" [CP:Cari Park_Iowa State University curator] subset: slim_pig relationship: part_of ID:0000104 ! meat color created_by: caripark creation_date: 2008-11-11T03:33:19Z [Term] id: ID:0000548 name: meat color L def: "objective meat color variable for lightness/darkness, based on the amount of light reflected off the surface of the meat" [CP:Cari Park_Iowa State University curator] subset: slim_pig relationship: part_of ID:0000104 ! meat color created_by: caripark creation_date: 2008-11-11T03:33:19Z [Term] id: ID:0000549 name: meat color score def: "subjective determination of meat color, on a scale ranging from pale to dark" [CP:Cari Park_Iowa State University curator] subset: slim_pig relationship: part_of ID:0000104 ! meat color created_by: caripark creation_date: 2008-11-11T03:33:19Z [Term] id: ID:0000550 name: hematin pigmentation def: "hematin pigment content in fresh muscle" [CP:Cari Park_Iowa State University curator] subset: slim_pig synonym: "haematin pigmentation" EXACT [] relationship: part_of ID:0000104 ! meat color created_by: caripark creation_date: 2008-11-11T03:33:19Z [Term] id: ID:0000551 name: meat color - hue def: "perceived meat color due to the dominant wavelength reflected=arctan(b/a)" [CP:Cari Park_Iowa State University curator] subset: slim_pig synonym: "hue angle" EXACT [] relationship: part_of ID:0000104 ! meat color created_by: caripark creation_date: 2008-11-11T03:33:19Z [Term] id: ID:0000552 name: light reflection subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T03:33:19Z [Term] id: ID:0000553 name: meat brightness subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T03:33:19Z [Term] id: ID:0000554 name: bone/lean meat ratio in ham def: "Weight of ham bone divided by the weight of lean meat in ham" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T03:57:04Z [Term] id: ID:0000555 name: dressing A def: "Weight of ham meat relative to carcass weight (%)" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T03:57:04Z [Term] id: ID:0000556 name: dressing B def: "Weight of bone-in ham relative to carcass weight (%)" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T03:57:04Z [Term] id: ID:0000557 name: carcass fat-free weight def: "weight of a carcass following slaughter and removal of the head, hide, intestinal tract, and internal organs, and subtracting the weight of fat" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_a: ID:0000114 ! carcass weight created_by: caripark creation_date: 2008-11-11T03:57:04Z [Term] id: ID:0000558 name: foreloin weight post-dissection subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T03:57:04Z [Term] id: ID:0000559 name: foreloin weight pre-dissection subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T03:57:04Z [Term] id: ID:0000560 name: ham external fat weight def: "weight of fat trimmed from the surface of the ham" [CP:Cari Park_Iowa State University curator] subset: slim_pig xref: CP:Cari Park_Iowa State University curator relationship: part_of ID:0000563 ! ham weight created_by: caripark creation_date: 2008-11-11T03:57:04Z [Term] id: ID:0000561 name: ham muscle weight def: "weight of ham with bone, skin, and fat removed" [CP:Cari Park_Iowa State University curator] subset: slim_pig synonym: "ham meat weight" EXACT [] is_a: ID:0000712 ! skeletal muscle weight relationship: part_of ID:0000563 ! ham weight created_by: caripark creation_date: 2008-11-11T03:57:04Z [Term] id: ID:0000562 name: ham percent def: "Weight of the untrimmed ham expressed as a percentage of carcass weight" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T03:57:04Z [Term] id: ID:0000563 name: ham weight def: "weight of the untrimmed cut of meat from the hind leg of the pig" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_a: ID:0000714 ! product weight relationship: part_of ID:0000689 ! hindlimb weight created_by: caripark creation_date: 2008-11-11T03:57:04Z [Term] id: ID:0000564 name: lean cuts subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T03:57:04Z [Term] id: ID:0000565 name: lean mass (weight) def: "Total weight of the trimmed wholesale meat cuts" [CP:Cari Park_Iowa State University curator] subset: slim_pig synonym: "lean meat weight" EXACT [] is_obsolete: true created_by: caripark creation_date: 2008-11-11T03:57:04Z [Term] id: ID:0000566 name: lean meat + bone in back def: "Weight of meat and bone in the loin (fat removed), expressed as a proportion of carcass weight" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T03:57:04Z [Term] id: ID:0000567 name: lean meat + bone in ham + back def: "Total weight of meat and bone in loin and ham, expressed as a proportion of carcass weight" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T03:57:04Z [Term] id: ID:0000568 name: lean percentage def: "An estimation of the percentage of lean meat in a carcass, based on various muscle and fat measurements" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T03:57:04Z [Term] id: ID:0000569 name: lean thickness between 3rd and 4th rib subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T03:57:04Z [Term] id: ID:0000570 name: loin and belly cut def: "Weight of the major wholesale cuts of loin and belly, expressed as a percentage of carcass weight" [CP:Cari Park_Iowa State University curator] subset: slim_pig synonym: "loin and belly percentage" EXACT [] is_obsolete: true created_by: caripark creation_date: 2008-11-11T03:57:04Z [Term] id: ID:0000571 name: loin and ham percentage def: "Weight of the loin and ham, expressed as a percentage of carcass weight" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T03:57:04Z [Term] id: ID:0000572 name: loin and neck meat weight def: "Weight of the loin and neck following the removal of external fat" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T03:57:04Z [Term] id: ID:0000573 name: loin eye area is_obsolete: true created_by: caripark creation_date: 2008-11-11T03:57:04Z [Term] id: ID:0000574 name: longissimus muscle area def: "Cross-sectional area of the loin muscle (longissimus dorsi)" [CP:Cari Park_Iowa State University curator] subset: slim_cattle subset: slim_pig synonym: "loin eye area" EXACT [] synonym: "loin muscle area" EXACT [] synonym: "rib eye area" EXACT [] is_a: ID:0000706 ! longissimus dorsi morphology created_by: caripark creation_date: 2008-11-11T03:57:04Z [Term] id: ID:0000575 name: longissimus muscle depth def: "the depth/diameter of the longissimus dorsi at a given point" [CP:Cari Park_Iowa State University curator] subset: slim_pig synonym: "eye muscle depth" EXACT [] synonym: "loin height" EXACT [] synonym: "loin muscle depth" EXACT [] is_a: ID:0000706 ! longissimus dorsi morphology created_by: caripark creation_date: 2008-11-11T03:57:04Z [Term] id: ID:0000576 name: loin percent def: "Weight of the loin expressed as a percentage of carcass weight" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T03:57:04Z [Term] id: ID:0000577 name: egg weight def: "weight of a whole, intact egg" [CP:Cari Park_Iowa State University curator] subset: slim_chkn relationship: part_of ID:0000015 ! egg product quality created_by: caripark creation_date: 2008-12-17T08:24:20Z [Term] id: ID:0000578 name: longissimus dorsi length def: "Length of the longissimus dorsi muscle" [CP:Cari Park_Iowa State University curator] subset: slim_pig synonym: "loin length" EXACT [] synonym: "longissimus muscle length" EXACT [] is_a: ID:0000706 ! longissimus dorsi morphology created_by: caripark creation_date: 2008-11-11T03:57:04Z [Term] id: ID:0000579 name: meat area on longissimus dorsi at 13th/14th rib subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T03:57:04Z [Term] id: ID:0000580 name: muscle + diaphragm weight subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T03:57:04Z [Term] id: ID:0000581 name: muscle weight subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T03:57:04Z [Term] id: ID:0000582 name: shoulder muscle weight def: "Weight of the cut of meat from the upper portion of the front leg of the pig, trimmed of fat" [CP:Cari Park_Iowa State University curator] subset: slim_pig synonym: "shoulder meat weight" EXACT [] is_obsolete: true created_by: caripark creation_date: 2008-11-11T03:57:04Z [Term] id: ID:0000583 name: loin muscle area at 4th-5th rib def: "Cross-sectional area of the loin muscle (longissimus dorsi) between the 4th and 5th rib" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T04:01:52Z [Term] id: ID:0000584 name: loin muscle area at the middle subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T04:01:52Z [Term] id: ID:0000585 name: FOM loin depth subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T04:02:23Z [Term] id: ID:0000586 name: loin depth at the last ribs subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T04:02:23Z [Term] id: ID:0000587 name: smell intensity (meat) def: "a subjective score describing the perceived odor intensity of cooked meat" [CP:Cari Park_Iowa State University curator] subset: slim_pig relationship: part_of ID:0000106 ! meat odor created_by: caripark creation_date: 2008-11-11T04:05:30Z [Term] id: ID:0000588 name: smell intensity (fat) def: "a subjective score describing the perceived odor intensity of cooked fat removed from a cut of meat" [CP:Cari Park_Iowa State University curator] subset: slim_pig relationship: part_of ID:0000106 ! meat odor created_by: caripark creation_date: 2008-11-11T04:05:30Z [Term] id: ID:0000589 name: sub-acid smell def: "A subjective score describing the intensity of an acidic or sour odor in cooked meat" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T04:05:30Z [Term] id: ID:0000590 name: subjective abnormal odor subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T04:05:30Z [Term] id: ID:0000591 name: meat odor acceptability subset: slim_pig synonym: "overall acceptability score" EXACT [] is_obsolete: true created_by: caripark creation_date: 2008-11-11T04:05:30Z [Term] id: ID:0000592 name: pork odor subset: slim_pig relationship: part_of ID:0000106 ! meat odor created_by: caripark creation_date: 2008-11-11T04:05:30Z [Term] id: ID:0000593 name: pH 24 hr post-mortem (ham) def: "pH of the semimembranosus muscle 24 hours after slaughter" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T04:09:18Z [Term] id: ID:0000594 name: pH 24 hr post-mortem (loin) def: "pH of the longissimus dorsi muscle 24 hours after slaughter" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T04:09:18Z [Term] id: ID:0000595 name: pH 45 min post-mortem def: "Muscle pH 45 minutes post-mortem" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T04:09:18Z [Term] id: ID:0000596 name: pH in biceps femoris muscle def: "relative acidity or alkalinity in the biceps femoris muscle, as measured by the concentration of hydrogen ion" [CP:Cari Park_Iowa State University curator] subset: slim_pig relationship: part_of ID:0000685 ! muscle pH created_by: caripark creation_date: 2008-11-11T04:09:18Z [Term] id: ID:0000597 name: pH in longissimus dorsi muscle def: "relative acidity or alkalinity in the longissimus dorsi muscle, as measured by the concentration of hydrogen ion" [CP:Cari Park_Iowa State University curator] subset: slim_pig relationship: part_of ID:0000685 ! muscle pH created_by: caripark creation_date: 2008-11-11T04:09:18Z [Term] id: ID:0000598 name: pH in semispinalis dorsi muscle def: "relative acidity or alkalinity in the semispinalis dorsi muscle, as measured by the concentration of hydrogen ion" [CP:Cari Park_Iowa State University curator] subset: slim_pig relationship: part_of ID:0000685 ! muscle pH created_by: caripark creation_date: 2008-11-11T04:09:18Z [Term] id: ID:0000599 name: pH in semimembranosus muscle def: "relative acidity or alkalinity in the semimembranosus muscle, as measured by the concentration of hydrogen ion" [CP:Cari Park_Iowa State University curator] subset: slim_pig relationship: part_of ID:0000685 ! muscle pH created_by: caripark creation_date: 2008-11-11T04:09:18Z [Term] id: ID:0000600 name: rigor mortis def: "Development of muscle rigidity that occurs post-mortem as a result of myosin-actin cross-bridging" [CP:Cari Park_Iowa State University curator, MeSH:C23.550.260.224.617.839] subset: slim_pig is_a: MT:0005395 ! other trait created_by: caripark creation_date: 2008-11-11T04:11:37Z [Term] id: ID:0000601 name: average instron (star probe) force def: "Amount of force (kg) necessary to puncture and/or compress a cut of cooked meat" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T04:15:56Z [Term] id: ID:0000602 name: meat chewiness def: "evaluation of the total number of chews required to sufficiently break up meat before swallowing" [CP:Cari Park_Iowa State University curator] subset: slim_pig synonym: "chew score" EXACT [] synonym: "chewiness score" EXACT [] relationship: part_of ID:0000109 ! meat texture created_by: caripark creation_date: 2008-11-11T04:15:56Z [Term] id: ID:0000603 name: cooking loss def: "decrease in the weight of a cut of meat during cooking, mostly due to moisture loss" [CP:Cari Park_Iowa State University curator] subset: slim_pig relationship: part_of ID:0000109 ! meat texture created_by: caripark creation_date: 2008-11-11T04:15:56Z [Term] id: ID:0000604 name: skeletal muscle fiber diameter def: "average diameter of the multinucleated cells in a cross-section of skeletal muscle" [CP:Cari Park_Iowa State University curator] subset: slim_pig relationship: part_of MT:0003399 ! skeletal muscle fiber size created_by: caripark creation_date: 2008-11-11T04:15:56Z [Term] id: ID:0000605 name: drip loss def: "fluid lost from fresh, uncooked meat due to passive exudation" [CP:Cari Park_Iowa State University curator] subset: slim_pig synonym: "purge" EXACT [] synonym: "purge loss" EXACT [] relationship: part_of ID:0000109 ! meat texture created_by: caripark creation_date: 2008-11-11T04:15:56Z [Term] id: ID:0000606 name: myosin isoform type I content def: "amount of myosin isoform type I present in a muscle sample, as determined by SDS-PAGE" [CP:Cari Park_Iowa State University curator] subset: slim_pig synonym: "fiber type 1 percentage" RELATED [] relationship: part_of ID:0000746 ! skeletal muscle fiber type created_by: caripark creation_date: 2008-11-11T04:15:56Z [Term] id: ID:0000607 name: myosin isoform type IIa content def: "amount of myosin isoform type IIa present in a muscle sample, as determined by SDS-PAGE" [CP:Cari Park_Iowa State University curator] subset: slim_pig relationship: part_of ID:0000746 ! skeletal muscle fiber type created_by: caripark creation_date: 2008-11-11T04:15:56Z [Term] id: ID:0000608 name: meat firmness def: "subjective evaluation of loin firmness following chilling of carcass" [CP:Cari Park_Iowa State University curator] subset: slim_pig relationship: part_of ID:0000109 ! meat texture created_by: caripark creation_date: 2008-11-11T04:15:56Z [Term] id: ID:0000609 name: meat juiciness def: "evaluation of the amount of liquid released by a piece of meat during chewing" [CP:Cari Park_Iowa State University curator] subset: slim_pig synonym: "juiciness score" EXACT [] relationship: part_of ID:0000109 ! meat texture created_by: caripark creation_date: 2008-11-11T04:15:56Z [Term] id: ID:0000610 name: lactate/diameter of white fibers subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T04:15:56Z [Term] id: ID:0000611 name: moisture content def: "amount of moisture in a cut of meat, determined by the difference in weight before and after oven drying" [CP:Cari Park_Iowa State University curator] subset: slim_pig relationship: part_of ID:0000109 ! meat texture created_by: caripark creation_date: 2008-11-11T04:15:56Z [Term] id: ID:0000612 name: number of type IIb myofibers def: "average number of type IIb, fast glycolytic fibers in a cross-section of muscle" [CP:Cari Park_Iowa State University curator] subset: slim_pig synonym: "number of white myofibers" EXACT [] relationship: part_of ID:0000746 ! skeletal muscle fiber type created_by: caripark creation_date: 2008-11-11T04:15:56Z [Term] id: ID:0000613 name: percent cooking loss def: "Decrease in the weight of a cut of meat during cooking, mostly due to moisture loss (%)." [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T04:15:56Z [Term] id: ID:0000614 name: percentage of white fibers def: "Number of white (fast-twitch) fibers/total number of fibers in a cross-section of muscle" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T04:15:56Z [Term] id: ID:0000615 name: adenosine deamination def: "degree of deamination of adenosine in muscle" [CP:Cari Park_Iowa State University curator] subset: slim_pig synonym: "R-value" EXACT [] is_a: MT:0002106 ! muscle physiology created_by: caripark creation_date: 2008-11-11T04:15:56Z [Term] id: ID:0000616 name: R-value/diameter of white fibers subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T04:15:56Z [Term] id: ID:0000617 name: conformation of feet and legs subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-12-19T12:57:50Z [Term] id: ID:0000618 name: meat tenderness def: "the ease with which meat is broken down during mastication" [CP:Cari Park_Iowa State University curator] subset: slim_cattle subset: slim_pig synonym: "tenderness score" EXACT [] relationship: part_of ID:0000109 ! meat texture created_by: caripark creation_date: 2008-11-11T04:15:56Z [Term] id: ID:0000619 name: water holding capacity def: "the ability of meat to retain water during cutting, heating, grinding, and pressing." [CP:Cari Park_Iowa State University curator] subset: slim_pig relationship: part_of ID:0000109 ! meat texture created_by: caripark creation_date: 2008-11-11T04:15:56Z [Term] id: ID:0000620 name: feed conversion ratio def: "Ratio of amount of feed consumed to body weight gain" [CP:Cari Park_Iowa State University curator] subset: slim_cattle subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T04:18:56Z [Term] id: ID:0000621 name: feed conversion ratio (35-55 kg) def: "Ratio of amount of feed consumed to body weight gain between 35 and 55 kg body weight" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T04:18:56Z [Term] id: ID:0000622 name: feed conversion ratio (55-80 kg) def: "Ratio of amount of feed consumed to body weight gain between 55 and 80 kg body weight" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T04:18:56Z [Term] id: ID:0000623 name: average daily feed intake def: "Average amount of feed consumed per day" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T04:20:49Z [Term] id: ID:0000624 name: feed intake (35-55 kg) subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T04:20:49Z [Term] id: ID:0000625 name: feed intake (55-80 kg) subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T04:20:49Z [Term] id: ID:0000626 name: food consumption is_obsolete: true created_by: caripark creation_date: 2008-11-11T04:20:49Z [Term] id: ID:0000627 name: thyroid-stimulating hormone subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T04:21:43Z [Term] id: ID:0000628 name: embryo mortality subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T04:27:06Z [Term] id: ID:0000629 name: fully formed pigs subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T04:27:06Z [Term] id: ID:0000630 name: litter weaning weight subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T04:27:06Z [Term] id: ID:0000631 name: mummified pigs subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T04:27:06Z [Term] id: ID:0000632 name: percentage stillborn subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T04:27:06Z [Term] id: ID:0000633 name: proportion of stillborn is_obsolete: true created_by: caripark creation_date: 2008-11-11T04:27:06Z [Term] id: ID:0000634 name: total number born synonym: "litter size" EXACT [] is_obsolete: true created_by: caripark creation_date: 2008-11-11T04:27:06Z [Term] id: ID:0000635 name: total number born alive synonym: "prenatal survival" EXACT [] is_obsolete: true created_by: caripark creation_date: 2008-11-11T04:27:06Z [Term] id: ID:0000636 name: number of corpora lutea subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T04:29:40Z [Term] id: ID:0000637 name: functional nipples def: "number of nipples capable of secreting milk in response to suckling by offspring" [CP:Cari Park_Iowa State University curator] subset: slim_pig relationship: part_of MT:0001881 ! mammary gland physiology created_by: caripark creation_date: 2008-11-11T04:29:40Z [Term] id: ID:0000638 name: uterine capacity def: "number of viable fetuses a female is capable of supporting to term" [CP:Cari Park_Iowa State University curator] subset: slim_pig relationship: part_of MT:0002637 ! uterus size created_by: caripark creation_date: 2008-11-11T04:29:40Z [Term] id: ID:0000639 name: uterine horn length def: "Length of the upper right or left portion of the uterus to which the uterine tube is connected" [CP:Cari Park_Iowa State University curator] subset: slim_pig relationship: part_of MT:0002637 ! uterus size created_by: caripark creation_date: 2008-11-11T04:29:40Z [Term] id: ID:0000640 name: uterine horn weight def: "Weight of the upper right or left portion of the uterus to which the uterine tube is connected" [CP:Cari Park_Iowa State University curator] subset: slim_pig relationship: part_of MT:0002637 ! uterus size created_by: caripark creation_date: 2008-11-11T04:29:40Z [Term] id: ID:0000641 name: ovary weight def: "Weight of the female reproductive gland containing the germ cells" [ISBN:0-683-40008-8 Stedman's Medical Dictionary\, 27th edition] subset: slim_pig relationship: part_of MT:0001127 ! ovary size created_by: caripark creation_date: 2008-11-11T04:29:40Z [Term] id: ID:0000642 name: uterus length def: "Length of the uterus from the top of the uterine body to the cervix" [CP:Cari Park_Iowa State University curator] subset: slim_pig synonym: "uterine length" EXACT [] relationship: part_of MT:0002637 ! uterus size created_by: caripark creation_date: 2008-11-11T04:29:40Z [Term] id: ID:0000643 name: daily sperm production def: "average number of sperm produced per day" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_a: MT:0001156 ! spermatogenesis created_by: caripark creation_date: 2008-11-11T04:30:44Z [Term] id: ID:0000644 name: testes weight def: "weight of the male reproductive glands" [CP:Cari Park_Iowa State University curator] subset: slim_pig relationship: part_of MT:0001148 ! testes size created_by: caripark creation_date: 2008-11-11T04:30:44Z [Term] id: ID:0000645 name: adjusted birthing rate subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T04:35:38Z [Term] id: ID:0000646 name: age at delivery subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T04:35:38Z [Term] id: ID:0000647 name: age at breeding subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T04:35:38Z [Term] id: ID:0000648 name: average breeding female inventory subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T04:35:38Z [Term] id: ID:0000649 name: birth interval def: "Time interval between birth of consecutive offspring" [CP:Cari Park_Iowa State University curator] subset: slim_cattle subset: slim_pig relationship: part_of MT:0002907 ! parturition created_by: caripark creation_date: 2008-11-11T04:35:38Z [Term] id: ID:0000650 name: birth duration def: "Duration of delivery" [CP:Cari Park_Iowa State University curator] subset: slim_pig relationship: part_of MT:0002907 ! parturition created_by: caripark creation_date: 2008-11-11T04:35:38Z [Term] id: ID:0000651 name: gestation length subset: slim_cattle subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T04:35:38Z [Term] id: ID:0000652 name: heterogeneity of birth intervals subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T04:35:38Z [Term] id: ID:0000653 name: lactation length def: "period of time over which milk is produced from the mammary gland" [CP:Cari Park_Iowa State University curator] subset: slim_pig relationship: part_of MT:0001882 ! lactation created_by: caripark creation_date: 2008-11-11T04:35:38Z [Term] id: ID:0000654 name: log transformation of percentage stillborn subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T04:35:38Z [Term] id: ID:0000655 name: placental efficiency subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T04:35:38Z [Term] id: ID:0000656 name: prenatal survival subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T04:35:38Z [Term] id: ID:0000657 name: vigor score subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T04:35:38Z [Term] id: ID:0000658 name: weight of laparoscopy subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2008-11-11T04:35:38Z [Term] id: ID:0000659 name: ACTH level variations def: "Difference between post-stress and basal levels of pituitary adrenocorticotropic hormone in the blood" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2009-01-09T10:26:05Z [Term] id: ID:0000660 name: cortisol level variations def: "Difference between post-stress and basal levels of cortisol in the blood" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2009-01-09T10:27:17Z [Term] id: ID:0000661 name: lymphocyte proliferation namespace: Trait.ontology subset: slim_pig is_a: MT:0000717 ! lymphocyte number created_by: caripark creation_date: 2009-02-23T11:12:21Z [Term] id: ID:0000662 name: residual feed intake def: "Difference between actual feed intake and the expected feed requirements for maintenance of body weight and for weight gain" [CP:Cari Park_Iowa State University curator] subset: slim_cattle is_a: MT:0005449 ! food intake created_by: caripark creation_date: 2009-03-06T02:22:41Z [Term] id: ID:0000663 name: susceptibility to M. paratuberculosis infection namespace: Trait.ontology def: "Likelihood that an organism will be infected with Mycobacterium avium subspecies paratuberculosis, the bacterium that causes Johne's disease in ruminants" [CP:Cari Park_Iowa State University curator] subset: slim_cattle is_obsolete: true created_by: caripark creation_date: 2009-03-06T02:30:59Z [Term] id: ID:0000664 name: feather morphology namespace: Trait.ontology subset: slim_chkn is_a: MT:0005393 ! skin/coat/nails/feathers trait created_by: caripark creation_date: 2009-03-10T01:08:34Z [Term] id: ID:0000665 name: bacteria count def: "number of viable bacteria present (cfu)" [CP:Cari Park_Iowa State University curator] subset: slim_chkn subset: slim_pig is_a: ID:0000673 ! response to bacterial infection created_by: caripark creation_date: 2009-03-13T11:09:51Z [Term] id: ID:0000666 name: femur width def: "width of the femur halfway between the ends" [CP:Cari Park_Iowa State University curator] is_a: ID:0000369 ! femur dimensions created_by: caripark creation_date: 2009-03-25T09:14:54Z [Term] id: ID:0000667 name: gizzard morphology def: "Any measurable or observable characteristic related to the shape, structure, color or pattern of the secondary, muscular stomach in some animals used for grinding up food" [CP:Cari Park_Iowa State University curator] subset: slim_chkn is_a: MT:0000462 ! digestive system morphology created_by: caripark creation_date: 2009-03-30T10:31:57Z [Term] id: ID:0000668 name: bursa of Fabricius size def: "Size of an epithelial outgrowth of the cloaca in birds where B-lymphocyte maturation occurs" [CP:Cari Park_Iowa State University curator, MeSH:A10.549.175] subset: slim_chkn is_a: MT:0002221 ! lymph organ size created_by: caripark creation_date: 2009-03-30T12:56:46Z [Term] id: ID:0000669 name: induced circulating adrenocorticotropin level namespace: Trait.ontology def: "Level of pituitary adrenocorticotropic hormone in the blood in response to an external intervention" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_a: MT:0002664 ! circulating adrenocorticotropin level created_by: caripark creation_date: 2009-03-30T01:49:48Z [Term] id: ID:0000670 name: circulating cortisol level def: "Blood concentration of a steroid hormone secreted by the adrenal cortex which acts as an anti-inflammatory agent" [CP:Cari Park_Iowa State University curator, ISBN:0-683-40008-8 "Stedman's Medical Dictionary, 27th edition"] subset: slim_pig synonym: "circulating hydrocortisone level" EXACT [] is_a: ID:0000672 ! cortisol level is_a: MT:0003366 ! circulating glucocorticoid level created_by: caripark creation_date: 2009-03-30T02:24:52Z [Term] id: ID:0000671 name: glucocorticoid level def: "Concentration of the corticosteroids regulating carbohydrate metabolism and exhibiting anti-inflammatory activity" [CP:Cari Park_Iowa State University curator, ISBN:0-683-40008-8 "Stedman's Medical Dictionary, 27th edition"] subset: slim_chkn subset: slim_pig is_a: MT:0003953 ! hormone level created_by: caripark creation_date: 2009-03-30T02:30:33Z [Term] id: ID:0000672 name: cortisol level def: "Concentration of a steroid hormone secreted by the adrenal cortex which acts as an anti-inflammatory agent" [CP:Cari Park_Iowa State University curator, ISBN:0-683-40008-8 "Stedman's Medical Dictionary, 27th edition"] subset: slim_pig synonym: "hydrocortisone level" EXACT [] is_a: ID:0000671 ! glucocorticoid level created_by: caripark creation_date: 2009-03-30T02:32:44Z [Term] id: ID:0000673 name: response to bacterial infection def: "The body's reaction to invasion and multiplication of bacteria in its tissues, or the body's reaction to components of or toxins produced by bacteria" [CP:Cari Park_Iowa State University curator] subset: slim_chkn subset: slim_pig is_a: MT:0005025 ! response to infection created_by: caripark creation_date: 2009-03-30T03:33:42Z [Term] id: ID:0000674 name: response to fungal infection def: "the body's reaction to invasion and multiplication of yeast or mold in its tissues, or the body's reaction to components of or toxins produced by these organisms" [CP:Cari Park_Iowa State University curator] is_a: MT:0005025 ! response to infection created_by: caripark creation_date: 2009-03-30T03:33:42Z [Term] id: ID:0000675 name: response to parasitic infection def: "the body's reaction to invasion and multiplication of parasites in its tissues, or the body's reaction to components of or toxins produced by parasites" [CP:Cari Park_Iowa State University curator] subset: slim_cattle subset: slim_chkn subset: slim_pig is_a: MT:0005025 ! response to infection created_by: caripark creation_date: 2009-03-30T03:33:42Z [Term] id: ID:0000676 name: response to prion infection def: "the body's reaction to invasion of small, infectious proteinaceous particles of non-nucleic acid composition in its tissues" [CP:Cari Park_Iowa State University curator, ISBN:0-683-40008-8 "Stedman's Medical Dictionary, 27th edition"] is_a: MT:0005025 ! response to infection created_by: caripark creation_date: 2009-03-30T03:33:42Z [Term] id: ID:0000677 name: response to viral infection def: "the body's reaction to invasion and multiplication of a virus in its tissues, or the body's reaction to components of or toxins produced by a virus" [CP:Cari Park_Iowa State University curator] is_a: MT:0005025 ! response to infection created_by: caripark creation_date: 2009-03-30T03:33:42Z [Term] id: ID:0000678 name: parasite load namespace: Trait.ontology is_obsolete: true created_by: caripark creation_date: 2009-03-30T04:00:58Z [Term] id: ID:0000679 name: interleukin-2 physiology def: "Characteristic related to the function of this cytokine released by helper T cells that stimulates proliferation of T lymphocytes and activated B lymphocytes" [CP:Cari Park_Iowa State University curator, ISBN:0-683-40008-8 "Stedman's Medical Dictionary, 27th edition"] subset: slim_pig is_a: MT:0002529 ! interleukin physiology created_by: caripark creation_date: 2009-03-31T03:12:32Z [Term] id: ID:0000680 name: weight loss in response to infection def: "loss of weight as a result of the invasion and multiplication of microorganisms, or due to the body's reaction to components of or toxins produced by pathogenic microorganisms" [CP:Cari Park_Iowa State University curator] subset: slim_cattle is_a: MT:0001263 ! weight loss is_a: MT:0005025 ! response to infection created_by: caripark creation_date: 2009-03-31T03:39:50Z [Term] id: ID:0000681 name: interleukin-2 activity def: "Activity of this cytokine released by helper T cells that stimulates proliferation of T lymphocytes and activated B lymphocytes" [CP:Cari Park_Iowa State University curator, ISBN:0-683-40008-8 "Stedman's Medical Dictionary, 27th edition"] subset: slim_pig is_a: ID:0000679 ! interleukin-2 physiology created_by: caripark creation_date: 2009-03-31T03:52:30Z [Term] id: ID:0000682 name: induced interleukin-2 activity def: "Activity of interleukin-2 in response to an external intervention" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_a: ID:0000681 ! interleukin-2 activity created_by: caripark creation_date: 2009-03-31T03:52:54Z [Term] id: ID:0000683 name: total heart ventricle size def: "The physical dimensions, proportions, magnitude, or extent of the lower chambers of the heart" [CP:Cari Park_Iowa State University curator] subset: slim_chkn relationship: part_of ID:0000059 ! total heart ventricle morphology created_by: caripark creation_date: 2009-04-01T03:44:26Z [Term] id: ID:0000684 name: total heart ventricle weight def: "Mass of the lower chambers of the heart times gravity" [CP:Cari Park_Iowa State University curator] subset: slim_chkn relationship: part_of ID:0000683 ! total heart ventricle size created_by: caripark creation_date: 2009-04-01T03:45:39Z [Term] id: ID:0000685 name: muscle pH def: "relative acidity or alkalinity in the muscle, as measured by the concentration of hydrogen ion" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_a: MT:0002106 ! muscle physiology is_a: MT:0004043 ! pH regulation created_by: caripark creation_date: 2009-04-01T03:49:05Z [Term] id: ID:0000686 name: paw/hand/foot/hoof weight def: "Weight of the pedal or prehensile extremity of vertebrates" [CP:Cari Park_Iowa State University curator] subset: slim_pig relationship: part_of MT:0004271 ! paw/hand/foot/hoof morphology created_by: caripark creation_date: 2009-04-01T04:28:54Z [Term] id: ID:0000687 name: forelimb weight def: "Weight of the anterior extremeties" [CP:Cari Park_Iowa State University curator] subset: slim_chkn subset: slim_pig relationship: part_of MT:0000550 ! forelimb morphology created_by: caripark creation_date: 2009-04-02T08:23:43Z [Term] id: ID:0000688 name: metatarsal bone weight namespace: Trait.ontology subset: slim_chkn synonym: "shank weight" NARROW [] relationship: part_of MT:0003072 ! metatarsal bone morphology created_by: caripark creation_date: 2009-04-02T11:09:39Z [Term] id: ID:0000689 name: hindlimb weight def: "weight of the posterior extremeties" [CP:Cari Park_Iowa State University curator] subset: slim_chkn relationship: part_of MT:0000556 ! hindlimb morphology created_by: caripark creation_date: 2009-04-02T11:41:35Z [Term] id: ID:0000690 name: flavor in meat subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2009-04-02T02:28:53Z [Term] id: ID:0000691 name: flavor in fat subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2009-04-02T02:29:20Z [Term] id: ID:0000692 name: humoral immune response rate namespace: Trait.ontology synonym: "antibody response rate" EXACT [] is_obsolete: true created_by: caripark creation_date: 2009-04-02T03:42:24Z [Term] id: ID:0000693 name: unsaturated fatty acid content subset: slim_pig is_obsolete: true created_by: caripark creation_date: 2009-04-02T04:12:49Z [Term] id: ID:0000694 name: muscle glycogen homeostasis def: "state of equilibrium in the body with respect to this readily converted carbohydrate reserve, found in most tissues, especially liver and muscle" [CP:Cari Park_Iowa State University curator, ISBN:0-683-40008-8 "Stedman's Medical Dictionary, 27th edition"] subset: slim_pig is_a: MT:0002106 ! muscle physiology created_by: caripark creation_date: 2009-04-03T09:59:55Z [Term] id: ID:0000695 name: egg albumen morphology def: "any measurable or observable characteristic related to the shape, structure, color or pattern of the albumen (white) of an egg" [CP:Cari Park_Iowa State University curator] subset: slim_chkn relationship: part_of ID:0000015 ! egg product quality created_by: caripark creation_date: 2009-04-03T11:33:39Z [Term] id: ID:0000696 name: egg shell morphology def: "any measurable or observable characteristic related to the shape, structure, color or pattern of the shell of an egg" [CP:Cari Park_Iowa State University curator] subset: slim_chkn relationship: part_of ID:0000015 ! egg product quality created_by: caripark creation_date: 2009-04-03T11:33:39Z [Term] id: ID:0000697 name: egg yolk morphology def: "any measurable or observable characteristic related to the shape, structure, color or pattern of the yolk of an egg" [CP:Cari Park_Iowa State University curator] subset: slim_chkn relationship: part_of ID:0000015 ! egg product quality created_by: caripark creation_date: 2009-04-03T11:33:39Z [Term] id: ID:0000698 name: egg shell physiology def: "any measurable characterisic related to the function of the shell of an egg" [CP:Cari Park_Iowa State University curator] subset: slim_chkn relationship: part_of ID:0000015 ! egg product quality created_by: caripark creation_date: 2009-04-03T11:35:44Z [Term] id: ID:0000699 name: egg yolk diameter subset: slim_chkn relationship: part_of ID:0000697 ! egg yolk morphology created_by: caripark creation_date: 2009-04-03T11:37:29Z [Term] id: ID:0000700 name: egg yolk height def: "height at the highest point of the yolk when an egg is broken onto a flat surface" [CP:Cari Park_Iowa State University curator] subset: slim_chkn relationship: part_of ID:0000697 ! egg yolk morphology created_by: caripark creation_date: 2009-04-03T11:37:29Z [Term] id: ID:0000701 name: product trait def: "any measurable or observable characteristic of a product produced by or obtained from the body of an animal" [CP:Cari Park_Iowa State University curator] subset: slim_cattle subset: slim_chkn subset: slim_pig is_a: MT:0000001 ! Trait created_by: caripark creation_date: 2009-04-06T02:14:59Z [Term] id: ID:0000702 name: udder cleft def: "upward extension and depth of the suspensory ligament separating the two halves of the udder" [CP:Cari Park_Iowa State University curator] subset: slim_cattle relationship: part_of ID:0000067 ! udder morphology created_by: caripark creation_date: 2009-04-23T08:43:06Z [Term] id: ID:0000703 name: udder depth def: "distance between udder floor and tarsal joint (point of the hock), viewed from the side" [CP:Cari Park_Iowa State University curator] subset: slim_cattle relationship: part_of ID:0000067 ! udder morphology created_by: caripark creation_date: 2009-04-23T08:43:06Z [Term] id: ID:0000704 name: rear udder height def: "distance from the udder floor to the point at the top where it joins the body wall" [CP:Cari Park_Iowa State University curator] subset: slim_cattle relationship: part_of ID:0000067 ! udder morphology created_by: caripark creation_date: 2009-04-23T08:43:06Z [Term] id: ID:0000705 name: rear udder width def: "width of the udder at the top of the rear udder attachment" [CP:Cari Park_Iowa State University curator] subset: slim_cattle relationship: part_of ID:0000067 ! udder morphology created_by: caripark creation_date: 2009-04-23T08:43:06Z [Term] id: ID:0000706 name: longissimus dorsi morphology namespace: Trait.ontology def: "any measurable or observable characteristic related to the shape, structure, color or pattern of the muscle of the back which is the intermediate and largest of the continuations of the Sacrospinalis" [ISBN:1587341026 "Gray's Anatomy"] subset: slim_cattle subset: slim_pig is_a: MT:0004248 ! epaxial muscle morphology created_by: caripark creation_date: 2009-04-23T01:15:57Z [Term] id: ID:0000707 name: skeletal muscle lean weight def: "actual or estimated weight of skeletal muscle, minus the associated fat" [CP:Cari Park_Iowa State University curator] subset: slim_pig synonym: "estimated carcass lean content" NARROW [] synonym: "lean mass" NARROW [] synonym: "lean meat weight" NARROW [] synonym: "lean muscle mass" EXACT [] is_a: ID:0000712 ! skeletal muscle weight created_by: caripark creation_date: 2009-04-27T02:57:55Z [Term] id: ID:0000708 name: reflectance value def: "a measurement of light reflection from the surface of meat, used to measure color or quantitate myoglobin forms" [CP:Cari Park_Iowa State University curator] subset: slim_pig synonym: "light reflection" EXACT [] relationship: part_of ID:0000104 ! meat color created_by: caripark creation_date: 2009-04-28T10:04:07Z [Term] id: ID:0000709 name: shoulder muscle weight def: "weight of the cut of meat from the upper portion of the front leg of the pig, trimmed of fat" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_a: ID:0000712 ! skeletal muscle weight relationship: part_of ID:0000422 ! shoulder weight created_by: caripark creation_date: 2009-04-28T01:47:10Z [Term] id: ID:0000710 name: pectoralis muscle morphology subset: slim_chkn is_obsolete: true created_by: caripark creation_date: 2009-04-28T01:59:13Z [Term] id: ID:0000711 name: abdominal fat pad weight def: "weight of the encapsulated adipose tissue in the abdomen" [CP:Cari Park_Iowa State University curator] subset: slim_chkn is_a: MT:0000010 ! abdominal fat pad morphology created_by: caripark creation_date: 2009-04-29T03:54:23Z [Term] id: ID:0000712 name: skeletal muscle weight def: "weight of one or more of the striated muscles attached to the skeleton" [CP:Cari Park_Iowa State University curator] subset: slim_cattle subset: slim_chkn subset: slim_pig is_a: MT:0003398 ! skeletal muscle size is_a: MT:0004233 ! muscle weight created_by: caripark creation_date: 2009-05-01T04:13:32Z [Term] id: ID:0000713 name: myosin isoform type IIb content def: "amount of myosin isoform type IIb present in a muscle sample, as determined by SDS-PAGE" [CP:Cari Park_Iowa State University curator] subset: slim_pig relationship: part_of ID:0000746 ! skeletal muscle fiber type created_by: caripark creation_date: 2009-05-01T05:21:37Z [Term] id: ID:0000714 name: product weight def: "weight of a product produced by or obtained from the body of an animal" [CP:Cari Park_Iowa State University curator] subset: slim_chkn subset: slim_pig is_a: ID:0000701 ! product trait created_by: caripark creation_date: 2009-05-04T03:19:20Z [Term] id: ID:0000715 name: egg morphology is_obsolete: true created_by: caripark creation_date: 2009-05-04T03:53:47Z [Term] id: ID:0000716 name: egg physiology is_obsolete: true created_by: caripark creation_date: 2009-05-04T03:53:47Z [Term] id: ID:0000717 name: response to novel food def: "reaction upon exposure to novel food" [CP:Cari Park_Iowa State University curator] subset: slim_chkn is_a: MT:0001431 ! eating behavior is_a: MT:0003107 ! response to novelty created_by: caripark creation_date: 2009-05-05T03:47:58Z [Term] id: ID:0000718 name: pH in semispinalis capitis muscle def: "relative acidity or alkalinity in the semispinalis capitis muscle, as measured by the concentration of hydrogen ion" [CP:Cari Park_Iowa State University curator] subset: slim_pig relationship: part_of ID:0000685 ! muscle pH created_by: caripark creation_date: 2009-05-05T03:53:48Z [Term] id: ID:0000719 name: ham bone weight def: "weight of bone in the ham" [CP:Cari Park_Iowa State University curator] subset: slim_pig relationship: part_of ID:0000563 ! ham weight created_by: caripark creation_date: 2009-05-06T09:06:13Z [Term] id: ID:0000720 name: nonfunctional nipples def: "number of nipples incapable of secreting milk in response to suckling by offspring" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_a: MT:0001881 ! mammary gland physiology created_by: caripark creation_date: 2009-05-06T09:39:43Z [Term] id: ID:0000721 name: band neutrophil count def: "number of immature neutrophils undergoing granulopoiesis; nuclei are unsegmented" [CP:Cari Park_Iowa State University curator, ISBN:0-683-40008-8 "Stedman's Medical Dictionary, 27th edition"] subset: slim_pig synonym: "band-formed neutrophil count" EXACT [] is_a: MT:0000222 ! neutrophil count created_by: caripark creation_date: 2009-05-06T10:28:10Z [Term] id: ID:0000722 name: milk energy yield def: "the energy content of milk; may be based on a combination of fat, protein, lactose, ash, and water content" [CP:Cari Park_Iowa State University curator] subset: slim_cattle relationship: part_of ID:0000019 ! milk product quality created_by: caripark creation_date: 2009-05-06T11:33:11Z [Term] id: ID:0000723 name: testes volume def: "volume of the male reproductive glands" [CP:Cari Park_Iowa State University curator] subset: slim_cattle relationship: part_of MT:0001148 ! testes size created_by: caripark creation_date: 2009-05-06T11:41:01Z [Term] id: ID:0000724 name: phytohemagglutin (PHA)-induced lymphocyte proliferation def: "proliferation of lymphocytes upon stimulation with phytohemagglutinin, a mucoprotein isolated from the kidney bean" [CP:Cari Park_Iowa State University curator, MeSH:D12.776.765.678.750] subset: slim_pig is_a: ID:0000393 ! mitogen-induced lymphocyte proliferation created_by: caripark creation_date: 2009-05-06T01:13:37Z [Term] id: ID:0000725 name: milking speed def: "subjective assessment of the time required for milking in relation to the milk yield" [CP:Cari Park_Iowa State University curator] is_a: MT:0001882 ! lactation created_by: caripark creation_date: 2009-05-06T03:11:07Z [Term] id: ID:0000726 name: angularity def: "conformation of the animal's back, withers, and neck, viewed from behind" [CP:Cari Park_Iowa State University curator] subset: slim_cattle synonym: "dairy form" EXACT [] is_a: ID:0000000 ! conformation created_by: caripark creation_date: 2009-05-06T03:13:00Z [Term] id: ID:0000727 name: teat placement def: "alignment of the teats in relation to each other" [CP:Cari Park_Iowa State University curator] subset: slim_cattle is_a: MT:0006078 ! nipple morphology created_by: caripark creation_date: 2009-05-06T03:19:16Z [Term] id: ID:0000728 name: is_obsolete: true created_by: caripark creation_date: 2009-05-06T03:22:23Z [Term] id: ID:0000729 name: carcass temperature def: "temperature of the carcass at a given time post-mortem" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_a: MT:0005535 ! body temperature created_by: caripark creation_date: 2009-05-07T09:43:03Z [Term] id: ID:0000730 name: height at withers def: "height of an animal measured from the ground to the high point on the back, between the shoulder blades" [CP:Cari Park_Iowa State University curator] subset: slim_cattle is_a: MT:0001253 ! body height created_by: caripark creation_date: 2009-05-07T11:05:57Z [Term] id: ID:0000731 name: chest width def: "width of the chest, viewed from the front" [CP:Cari Park_Iowa State University curator] subset: slim_cattle synonym: "strength" RELATED [] relationship: part_of MT:0004134 ! chest morphology created_by: caripark creation_date: 2009-05-07T12:48:20Z [Term] id: ID:0000732 name: chest depth def: "dorsal-ventral dimension of the chest, measured directly behind the front legs" [CP:Cari Park_Iowa State University curator] subset: slim_cattle relationship: part_of MT:0004134 ! chest morphology created_by: caripark creation_date: 2009-05-07T12:59:41Z [Term] id: ID:0000733 name: heel depth def: "vertical distance from the ground to the hairline at the back of the hoof" [CP:Cari Park_Iowa State University curator] subset: slim_cattle relationship: part_of MT:0004271 ! paw/hand/foot/hoof morphology created_by: caripark creation_date: 2009-05-07T01:17:19Z [Term] id: ID:0000734 name: hoof diagonal def: "distance from the tip of the hoof to the hairline at the back of the hoof" [CP:Cari Park_Iowa State University curator] subset: slim_cattle synonym: "foot diagonal" EXACT [] relationship: part_of MT:0004271 ! paw/hand/foot/hoof morphology created_by: caripark creation_date: 2009-05-07T01:17:19Z [Term] id: ID:0000735 name: hoof angle def: "angle at which the hoof wall meets the ground" [CP:Cari Park_Iowa State University curator] subset: slim_cattle synonym: "foot angle" EXACT [] relationship: part_of MT:0004271 ! paw/hand/foot/hoof morphology created_by: caripark creation_date: 2009-05-07T01:17:19Z [Term] id: ID:0000736 name: temperament def: "general attitude or characteristic reactions of an organism exhibited toward another organism" [CP:Cari Park_Iowa State University curator] subset: slim_cattle is_a: MT:0002557 ! social/conspecific interaction created_by: caripark creation_date: 2009-05-07T01:31:27Z [Term] id: ID:0000737 name: hind leg set def: "squareness of the hind legs in relation to the body; may be assessed from the side or from behind" [CP:Cari Park_Iowa State University curator] subset: slim_cattle synonym: "rear leg set" EXACT [] relationship: part_of MT:0000556 ! hindlimb morphology created_by: caripark creation_date: 2009-05-07T01:44:48Z [Term] id: ID:0000738 name: conformation of feet and legs def: "assessment of the overall structure and proportions of the feet and legs" [CP:Cari Park_Iowa State University curator] subset: slim_cattle is_a: ID:0000000 ! conformation is_a: MT:0002109 ! limb morphology created_by: caripark creation_date: 2009-05-07T01:53:41Z [Term] id: ID:0000739 name: rump morphology def: "any measurable or observable characteristic related to the shape or structure of the hindquarters" [CP:Cari Park_Iowa State University curator] subset: slim_cattle is_a: MT:0002089 ! postnatal growth/weight/body size created_by: caripark creation_date: 2009-05-07T02:23:12Z [Term] id: ID:0000740 name: rump width def: "distance between the caudal protrusions of the pelvis, viewed from behind" [CP:Cari Park_Iowa State University curator] subset: slim_cattle synonym: "thurl width" EXACT [] relationship: part_of ID:0000739 ! rump morphology created_by: caripark creation_date: 2009-05-07T02:27:08Z [Term] id: ID:0000741 name: rump angle def: "slope of the topline of the rump, between the cranial and caudal protrusions of the pelvic bone, viewed from the side" [CP:Cari Park_Iowa State University curator] subset: slim_cattle relationship: part_of ID:0000739 ! rump morphology created_by: caripark creation_date: 2009-05-07T02:27:08Z [Term] id: ID:0000742 name: sarcomere length def: "length of the segment of a myofibril between two Z lines" [CP:Cari Park_Iowa State University curator, ISBN:0-683-40008-8 "Stedman's Medical Dictionary, 27th edition"] subset: slim_pig is_a: MT:0004090 ! sarcomere morphology created_by: caripark creation_date: 2009-05-07T02:45:53Z [Term] id: ID:0000743 name: skeletal muscle fiber number def: "number of large multinucleated cells in a cross-section of skeletal muscle" [CP:Cari Park_Iowa State University curator] subset: slim_pig relationship: part_of MT:0003084 ! skeletal muscle fiber morphology created_by: caripark creation_date: 2009-05-07T03:19:34Z [Term] id: ID:0000744 name: neck weight def: "weight of the cut of meat from the dorsal side of the pig, anterior to the third rib" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_a: ID:0000714 ! product weight created_by: caripark creation_date: 2009-05-07T03:37:37Z [Term] id: ID:0000745 name: jowl weight def: "weight of the cut of meat obtained from the cheek of the pig" [CP:Cari Park_Iowa State University curator] subset: slim_pig is_a: ID:0000714 ! product weight created_by: caripark creation_date: 2009-05-07T03:46:46Z [Term] id: ID:0000746 name: skeletal muscle fiber type subset: slim_pig is_a: MT:0002106 ! muscle physiology created_by: caripark creation_date: 2009-05-07T03:52:39Z [Term] id: ID:0000747 name: number of type I myofibers def: "average number of type I, slow oxidative fibers in a cross-section of muscle" [CP:Cari Park_Iowa State University curator] subset: slim_pig relationship: part_of ID:0000746 ! skeletal muscle fiber type created_by: caripark creation_date: 2009-05-07T07:22:41Z [Term] id: ID:0000748 name: number of type IIa myofibers def: "average number of type IIa, fast oxidative fibers in a cross-section of muscle" [CP:Cari Park_Iowa State University curator] subset: slim_pig relationship: part_of ID:0000746 ! skeletal muscle fiber type created_by: caripark creation_date: 2009-05-07T07:22:41Z [Term] id: ID:0000749 name: area of type I myofibers namespace: Trait.ontology def: "total area in a cross-section of skeletal muscle occupied by type I, slow oxidative fibers" [CP:Cari Park_Iowa State University curator] subset: slim_pig relationship: part_of MT:0003399 ! skeletal muscle fiber size created_by: caripark creation_date: 2009-05-07T07:31:16Z [Term] id: ID:0000750 name: area of type IIa myofibers namespace: Trait.ontology def: "total area in a cross-section of skeletal muscle occupied by type IIa, fast oxidative fibers" [CP:Cari Park_Iowa State University curator] subset: slim_pig relationship: part_of MT:0003399 ! skeletal muscle fiber size created_by: caripark creation_date: 2009-05-07T07:31:16Z [Term] id: ID:0000751 name: area of type IIb myofibers namespace: Trait.ontology def: "total area in a cross-section of skeletal muscle occupied by type IIb, fast glycolytic fibers" [CP:Cari Park_Iowa State University curator] subset: slim_pig relationship: part_of MT:0003399 ! skeletal muscle fiber size created_by: caripark creation_date: 2009-05-07T07:31:16Z [Term] id: ID:0000752 name: number of IgM-positive B cells def: "subpopulation of peripheral blood mononuclear cells that stain positive for immunoglobulin M" [CP:Cari Park_Iowa State University curator] subset: slim_pig synonym: "IgM-positive leukocytes" EXACT [] is_a: MT:0002459 ! B cell physiology created_by: caripark creation_date: 2009-05-07T07:45:57Z [Term] id: ID:0000753 name: number of CD4+ T cells def: "subpopulation of peripheral blood mononuclear cells that stain positive for CD4" [CP:Cari Park_Iowa State University curator] subset: slim_pig synonym: "number of CD4-positive leukocytes" EXACT [] is_a: MT:0005463 ! CD4+ T cell physiology created_by: caripark creation_date: 2009-05-07T07:50:21Z [Term] id: ID:0000754 name: number of CD8+ T cells def: "subpopulation of peripheral blood mononuclear cells that stain positive for CD8" [CP:Cari Park_Iowa State University curator] subset: slim_pig synonym: "number of CD8-positive leukocytes" EXACT [] is_a: MT:0004392 ! CD8+ T cell physiology created_by: caripark creation_date: 2009-05-07T07:51:21Z [Term] id: ID:0000755 name: number of N1c-positive T cells def: "subpopulation of peripheral blood mononuclear cells expressing gamma and delta chains of the T cell receptor" [CP:Cari Park_Iowa State University curator] subset: slim_pig synonym: "number of N1c-positive leukocytes" EXACT [] is_a: MT:0002444 ! T cell physiology created_by: caripark creation_date: 2009-05-07T07:53:29Z [Term] id: ID:0000756 name: number of MHCII-positive B cells def: "subpopulation of peripheral blood mononuclear cells that stain positive for major histocompatibility complex class II" [CP:Cari Park_Iowa State University curator] subset: slim_pig synonym: "MHCII-positive leukocytes" EXACT [] is_a: MT:0002459 ! B cell physiology created_by: caripark creation_date: 2009-05-07T07:57:05Z [Term] id: ID:0000757 name: number of CD2-positive lymphocytes def: "subpopulation of peripheral blood mononuclear cells that stain positive for CD2" [CP:Cari Park_Iowa State University curator] synonym: "number of CD2-positive leukocytes" EXACT [] is_a: MT:0003945 ! lymphocyte physiology created_by: caripark creation_date: 2009-05-07T07:59:29Z [Term] id: MT:0000001 name: Trait namespace: Trait.ontology subset: slim_cattle subset: slim_chkn subset: slim_pig [Term] id: MT:0000002 name: head size namespace: Trait.ontology def: "physical dimensions of the head" [smb:MGI_curator] subset: slim_pig is_a: MT:0000432 ! head morphology [Term] id: MT:0000003 name: adipose tissue morphology namespace: Trait.ontology alt_id: MT:0000011 subset: slim_cattle subset: slim_chkn subset: slim_pig synonym: "adipose tissue abnormalities" EXACT [] is_a: MT:0005375 ! adipose tissue trait [Term] id: MT:0000005 name: right atrium size namespace: Trait.ontology def: "the physical dimensions, proportions, magnitude, or extent of the right upper chamber of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] synonym: "right atrial size" RELATED [] is_a: MT:0003140 ! atrium size relationship: part_of MT:0000019 ! right atrium morphology [Term] id: MT:0000006 name: atrial appendage completeness namespace: Trait.ontology def: "any measurable or observable characteristic pertaining to the wholeness of the small trabeculated chamber projecting from the atrium proper" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] relationship: part_of MT:0004253 ! atrium appendage integrity [Term] id: MT:0000008 name: atrium appendage configuration namespace: Trait.ontology def: "any measurable characteristic of the arrangement of the small trabeculated chamber projecting from the atrium proper" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] synonym: "atrial appendage configuration" RELATED [] relationship: part_of MT:0000024 ! atrium appendage morphology [Term] id: MT:0000009 name: atrium septum completeness namespace: Trait.ontology def: "any measurable or observable characteristic pertaining to the wholeness of the wall between the upper chambers of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] synonym: "atrial septal completeness" RELATED [] relationship: part_of MT:0000282 ! atrium septum integrity [Term] id: MT:0000010 name: abdominal fat pad morphology namespace: Trait.ontology def: "any measurable or observable characteristic related to the shape, structure, color or pattern of the encapsulated adipose tissue in the abdomen" [CP:Cari Park_Iowa State University curator] subset: slim_chkn is_a: MT:0005334 ! fat pad morphology [Term] id: MT:0000012 name: left atrium size namespace: Trait.ontology def: "the physical dimensions, proportions, magnitude, or extent of the left upper chamber of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] synonym: "left atrial size" RELATED [] is_a: MT:0003140 ! atrium size relationship: part_of MT:0000020 ! left atrium morphology [Term] id: MT:0000013 name: fat distribution namespace: Trait.ontology subset: slim_cattle subset: slim_pig is_a: MT:0000003 ! adipose tissue morphology [Term] id: MT:0000015 name: outer ear pigmentation namespace: Trait.ontology def: "coloration of the outer ear" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] is_a: MT:0002095 ! skin pigmentation is_a: MT:0002177 ! outer ear morphology [Term] id: MT:0000017 name: ear size namespace: Trait.ontology def: "length, width, or area of the outer ears " [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "outer ear size" RELATED [] is_a: MT:0002177 ! outer ear morphology [Term] id: MT:0000018 name: ventricle membranous septum morphology namespace: Trait.ontology def: "any measurable or observable structural characteristic of the membranous portion of the wall between the lower chambers of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] synonym: "interventricular membranous septum thickness" RELATED [] synonym: "ventricular membranous septal thickness" RELATED [] relationship: part_of MT:0007082 ! ventricle septum morphology [Term] id: MT:0000019 name: right atrium morphology namespace: Trait.ontology def: "any measurable or observable characteristic related to the shape, structure, color or pattern of the right upper chamber of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] synonym: "right atrial morphology" RELATED [] is_a: MT:0003105 ! heart atrium morphology [Term] id: MT:0000020 name: left atrium morphology namespace: Trait.ontology def: "any measurable or observable characteristic related to the shape, structure, color or pattern of the left upper chamber of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] synonym: "left atrial morphology" RELATED [] is_a: MT:0003105 ! heart atrium morphology [Term] id: MT:0000021 name: outer ear prominence namespace: Trait.ontology def: "distance from the outer edge of the outer ear to the head" [J:61768] is_a: MT:0002177 ! outer ear morphology [Term] id: MT:0000022 name: ear shape namespace: Trait.ontology def: "pattern of the external ear" [J:65038] is_a: MT:0002177 ! outer ear morphology [Term] id: MT:0000023 name: ear distance/ position namespace: Trait.ontology def: "distance between or the placement of the outer ears " [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] is_a: MT:0002177 ! outer ear morphology [Term] id: MT:0000024 name: atrium appendage morphology namespace: Trait.ontology def: "any measurable or observable characteristic related to the shape, structure, color or pattern of the small trabeculated chamber projecting from the atrium proper" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] synonym: "atrial appendage morphology" RELATED [] relationship: part_of MT:0003105 ! heart atrium morphology [Term] id: MT:0000025 name: atrioventricular valve morphology namespace: Trait.ontology def: "any measurable or observable characteristic related to the shape, structure, color or pattern of the valves that gate the flow of blood from the atria into the ventricles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] is_a: MT:0000285 ! heart valve morphology [Term] id: MT:0000026 name: inner ear morphology namespace: Trait.ontology def: "malformation or malfunction of any components of the labyrinth, including the semicircular canals, vestibule and cochlea" [J:1776, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] xref: GO:0042472 is_a: MT:0002102 ! ear morphology [Term] id: MT:0000027 name: head width namespace: Trait.ontology def: "ear to ear distance across the head" [smb:MGI_curator] is_a: MT:0000002 ! head size [Term] id: MT:0000028 name: pars superior vestibularis morphology namespace: Trait.ontology def: "form or structure of the part of the vestibular ganglion that receives fibers from the maculae of the utricle and the sacculae and the ampullae of the anterior and lateral semicircular ducts" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000026 ! inner ear morphology is_a: MT:0002856 ! vestibular ganglion morphology [Term] id: MT:0000029 name: malleus morphology namespace: Trait.ontology def: "form or structure of the largest of the three auditory ossicles, which resembles a club or hammer " [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal malleus" EXACT [] is_a: MT:0005105 ! middle ear ossicle morphology [Term] id: MT:0000030 name: tympanic ring morphology namespace: Trait.ontology def: "form or structure of the bony ring at the ear canal to which the tympanic membrane is attached" [J:23837, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000049 ! middle ear morphology [Term] id: MT:0000031 name: cochlea morphology namespace: Trait.ontology def: "form or structure of the spiral-shaped bony canal in the inner ear containing the hair cells that transduce sound" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000026 ! inner ear morphology [Term] id: MT:0000032 name: cochlear integrity namespace: Trait.ontology def: "susceptibility of the cochlea to degeneration or atrophy" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0000031 ! cochlea morphology [Term] id: MT:0000033 name: mitral valve morphology namespace: Trait.ontology def: "any measurable or observable characteristic related to the shape, structure, color or pattern of the valve between the left atrium and the left ventricle of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] is_a: MT:0000025 ! atrioventricular valve morphology [Term] id: MT:0000034 name: vestibule morphology namespace: Trait.ontology def: "form or structure of the cavity between the semicircular canals and the cochlea of the inner ear" [J:1776, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000026 ! inner ear morphology [Term] id: MT:0000035 name: membranous labyrinth namespace: Trait.ontology def: "form or structure of the complex arrangement of communicating canaliculi and sacs suspended within the cavity of the bony labyrinth of the inner ear" [J:23837, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000026 ! inner ear morphology [Term] id: MT:0000036 name: tricuspid valve morphology namespace: Trait.ontology def: "any measurable or observable characteristic related to the shape, structure, color or pattern of the valve between the right atrium and the right ventricle of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] is_a: MT:0000025 ! atrioventricular valve morphology [Term] id: MT:0000037 name: lateral semicircular canal namespace: Trait.ontology def: "shape or structure of the lateral long bony tube of the labyrinth that is involved in the sense of balance " [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, smb:Susan M. Bello_Mouse Genome Informatics Curator] synonym: "abnormal horizontal semicircular canal" EXACT [] is_a: MT:0002428 ! semicircular canal [Term] id: MT:0000038 name: head length namespace: Trait.ontology def: "anterior to posterior length of the head" [smb:MGI_curator] is_a: MT:0000002 ! head size [Term] id: MT:0000039 name: otic capsule morphology namespace: Trait.ontology def: "form or structure of the cartilage or bony capsule surrounding the inner ear mechanism" [J:23837, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "periotic capsule morphology" EXACT [] is_a: MT:0000026 ! inner ear morphology [Term] id: MT:0000040 name: aortic valve morphology namespace: Trait.ontology def: "any measurable or observable characteristic related to the shape, structure, color or pattern of the valve between the left ventricle and the ascending aorta" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] is_a: MT:0002746 ! semilunar valve morphology [Term] id: MT:0000041 name: endolymphatic duct size namespace: Trait.ontology def: "length, width, or area of the small membranous canal of the inner ear; connecting membranous labyrinth with the endolymphatic sac" [J:1776, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0006011 ! endolymphatic duct morphology [Term] id: MT:0000042 name: organ of Corti namespace: Trait.ontology def: "form or structure of the highly specialized epithelium in the floor of the ductus cochlearis; also referred to a spiral organ (organum spirale), or acoustic papilla" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "spiral organ morphology" EXACT [] is_a: MT:0003169 ! scala media morphology [Term] id: MT:0000043 name: organ of Corti integrity namespace: Trait.ontology def: "susceptibility to impairment of function or destruction of the highly specialized epithelium in the floor of the ductus cochlearis" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "susceptibility to degeneration of organ of Corti" EXACT [] is_a: MT:0000042 ! organ of Corti [Term] id: MT:0000044 name: pulmonary valve morphology namespace: Trait.ontology def: "any measurable or observable characteristic related to the shape, structure, color or pattern of the valve between the right ventricle and the pulmonary trunk" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] is_a: MT:0002746 ! semilunar valve morphology [Term] id: MT:0000045 name: hair cell morphology namespace: Trait.ontology def: "form, structure, organization or number of the sensory epithelial cells of the inner ear" [pvb:Pierre Vanden Borre_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal hair cells" EXACT [] is_a: MT:0000026 ! inner ear morphology is_a: MT:0000972 ! mechanoreceptor morphology [Term] id: MT:0000046 name: sulcus ampullaris morphology namespace: Trait.ontology def: "form or structure of the transverse groove on the membranous amupulla of each semicircular duct, where the nerve enters the ampullary crest" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "ampullary groove morphology" EXACT [] synonym: "ampullary sulcus morphology" EXACT [] is_a: MT:0000026 ! inner ear morphology [Term] id: MT:0000047 name: head circumference namespace: Trait.ontology is_a: MT:0000002 ! head size [Term] id: MT:0000048 name: stria vascularis morphology namespace: Trait.ontology def: "form or structure of the stratified, secretory epithelium which lines the upper part of the cochlear spiral ligament and maintains K+ homeostasis in the endolymph; stria vascularis normally consists of marginal, intermediate, and basal cells: basal and marginal cell tight junctions preclude paracellular diffusion into and out of the intrastrial space while basal and intermediate cells secrete into this space K+ derived from fibrocytes through gap junctions" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "psalterial cord morphology" EXACT [] synonym: "stria vascularis ductus cochlearis morphology" EXACT [] synonym: "vascular stripe morphology" EXACT [] is_a: MT:0003169 ! scala media morphology [Term] id: MT:0000049 name: middle ear morphology namespace: Trait.ontology def: "form or structure of any components of the tympanic cavity or its ossicles" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002102 ! ear morphology [Term] id: MT:0000051 name: testes physiology namespace: Trait.ontology is_a: MT:0005647 ! sex gland physiology [Term] id: MT:0000052 name: onset of ear unfolding namespace: Trait.ontology def: "timing of the initiation of opening and spreading out of the outer ear" [J:39752] is_a: MT:0002177 ! outer ear morphology [Term] id: MT:0000053 name: heart integrity namespace: Trait.ontology def: "any measurable characteristic pertaining to the structural completeness or structural soundness of the organ that pumps blood through the body" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] synonym: "cardiac integrity" RELATED [] relationship: part_of MT:0000266 ! cardiac morphology [Term] id: MT:0000054 name: onset of ear emergence namespace: Trait.ontology def: "timing of the start of the growth of the outer ear" [J:49421] synonym: "onset of ear elevation" EXACT [] synonym: "onset of ear extroversion" EXACT [] is_a: MT:0002177 ! outer ear morphology [Term] id: MT:0000057 name: osteogenesis namespace: Trait.ontology alt_id: MT:0001535 alt_id: MT:0001536 def: "anomalous process of bone formation" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal bone formation" EXACT [] synonym: "abnormal osteogenesis" EXACT [] synonym: "abnormal skeletogenesis" EXACT [] synonym: "osteogenesis abnormalities" EXACT [] synonym: "skeletogenesis abnormalities" EXACT [] is_a: MT:0002113 ! skeleton development [Term] id: MT:0000058 name: heart muscle compact layer morphology namespace: Trait.ontology def: "any measurable or observable characteristic related to the shape, structure, color or pattern of the outer, dense layer of the myocardium" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] synonym: "myocardial compact layer morphology" RELATED [] relationship: part_of MT:0005329 ! heart muscle morphology [Term] id: MT:0000059 name: osteoclast formation namespace: Trait.ontology def: "anomalous development of this multinucleated cell, which normally functions in the absorption and removal of osseous tissue" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal osteophage formation" EXACT [] is_a: MT:0000057 ! osteogenesis [Term] id: MT:0000060 name: onset of bone ossification namespace: Trait.ontology def: "late onset of the formation of bone" [J:40203] is_a: MT:0000057 ! osteogenesis [Term] id: MT:0000061 name: heart muscle fiber morphology namespace: Trait.ontology def: "any measurable or observable characteristic related to the shape, structure, color or pattern of the multinucleated muscle cells comprising the myocardium" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] synonym: "myocardial fiber morphology" RELATED [] relationship: part_of MT:0005329 ! heart muscle morphology [Term] id: MT:0000062 name: heart muscle trabeculae morphology namespace: Trait.ontology def: "any measurable or observable characteristic related to the shape, structure, color or pattern of the supporting bundles of muscular fibers lining the walls of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] synonym: "cardiac muscle trabeculae morphology" RELATED [] synonym: "myocardial trabeculae morphology" RELATED [] relationship: part_of MT:0005329 ! heart muscle morphology [Term] id: MT:0000063 name: ventricle papillary muscle morphology namespace: Trait.ontology def: "any measurable or observable characteristic related to the shape, structure, color or pattern of the group of myocardial bundles which terminate in the chordae tendineae that attach to the cusps of the atrioventricular valves; each ventricle has an anterior and a posterior papillary muscle; the right ventricle sometimes has a septal papillary muscle" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] synonym: "musculus papillaris morphology" RELATED [] xref: MP:0004058 relationship: part_of MT:0005294 ! heart ventricle morphology relationship: part_of MT:0005329 ! heart muscle morphology [Term] id: MT:0000064 name: secondary bone resorption namespace: Trait.ontology def: "inability of osteoclasts to degrade the organic and inorganic phases of bone by absorption" [J:61295, J:67040] is_a: MT:0001541 ! osteoclast physiology [Term] id: MT:0000065 name: bone marrow cavity morphology namespace: Trait.ontology def: "absence or abnormal size or shape of the medullary cavities of the bones" [J:61295, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000168 ! bone marrow development [Term] id: MT:0000066 name: osteoporosis namespace: Trait.ontology def: "reduction in bone mass or atrophy of skeletal tissue; may lead to skeletal fragility" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, J:57315, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "reduced bone mass" EXACT [] is_a: MT:0004016 ! bone mass [Term] id: MT:0000067 name: osteopetrosis namespace: Trait.ontology def: "excessive formation of dense trabecular bone and excessive calcified cartilage formation; may lead to anemia and extramedullary hematopoiesis " [MeSH:National Library of Medicine_Medical Subject Headings, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0004016 ! bone mass [Term] id: MT:0000069 name: kyphoscoliosis namespace: Trait.ontology def: "kyphosis combined with scoliosis" [cml:Cathleen M. Lutz_Mouse Genome Informatics Curator, J:66943] is_a: MT:0004174 ! spine curvature [Term] id: MT:0000071 name: axial skeleton cell number namespace: Trait.ontology def: "reduced cell number in the skeletal elements of the trunk" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, J:55583, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "hypoplastic axial skeleton" EXACT [] is_a: MT:0002114 ! axial skeleton morphology [Term] id: MT:0000073 name: heart muscle integrity namespace: Trait.ontology def: "any measurable characteristic pertaining to the the structural completeness or structural soundness of the involuntary muscle comprising the myocardium" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] synonym: "cardiac muscle integrity" RELATED [] synonym: "myocardial integrity" RELATED [] relationship: part_of MT:0000053 ! heart integrity relationship: part_of MT:0005329 ! heart muscle morphology [Term] id: MT:0000074 name: neurocranium morphology namespace: Trait.ontology def: "malformed bones of the skull enclosing the brain" [J:55583, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal neurocranium" EXACT [] is_a: MT:0000438 ! skull morphology [Term] id: MT:0000075 name: blood-brain barrier morphology namespace: Trait.ontology def: "any measurable or observable characteristic related to the shape, structure, color or pattern of the group of barriers and transport systems in the brain capillary endothelium that controls the entrance of substances into the brain extracellular space from the blood" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] relationship: part_of MT:0001614 ! blood vessel morphology [Term] id: MT:0000076 name: calvaria morphology namespace: Trait.ontology def: "malformed upper domelike portion of the skull" [J:61509] synonym: "abnormal calvaria" EXACT [] synonym: "abnormal cranial vault" EXACT [] is_a: MT:0000074 ! neurocranium morphology [Term] id: MT:0000077 name: interparietal bone morphology namespace: Trait.ontology alt_id: MT:0000110 def: "any structural anomaly of the bone of the cranium that lies above and anterior to the occipital bone in some mammals" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, J:61509] synonym: "abnormal interparietal bone" EXACT [] is_a: MT:0000076 ! calvaria morphology [Term] id: MT:0000078 name: supraoccipital bone morphology namespace: Trait.ontology def: "any structural anomaly of the bone on the dorsal side of the great foramen of the skull, usually forming a part of the occipital in the adult, but distinct in the young" [J:61509] synonym: "abnormal supraoccipital bone" EXACT [] is_a: MT:0005269 ! occipital bone morphology [Term] id: MT:0000079 name: basioccipital bone morphology namespace: Trait.ontology def: "any structural anomaly of the basilar process of the occipital bone in the base of the cranium, frequently forming a direct part of the occipital in the adult, but usually distinct in the young " [J:55583, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal basioccipital bone" EXACT [] is_a: MT:0005269 ! occipital bone morphology [Term] id: MT:0000080 name: exoccipital bone morphology namespace: Trait.ontology def: "any structural anomaly of the bone or region on the lateral sides of the great foremen of the skull, which often forms a part of the occipital in the adult, but is usually distinct in the young" [J:23837, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal exoccipital bone" EXACT [] is_a: MT:0005269 ! occipital bone morphology [Term] id: MT:0000081 name: onset of suture closure namespace: Trait.ontology alt_id: MT:0005268 def: "early fusion of the bones of the skull" [J:26513] synonym: "craniostosis" EXACT [] synonym: "craniosynostosis" EXACT [] is_a: MT:0003420 ! onset of intramembranous bone ossification [Term] id: MT:0000082 name: overlapping parietal bones namespace: Trait.ontology def: "parietal bones of the skull partly coincide instead of articulating" [J:26513] is_a: MT:0000109 ! parietal bone morphology [Term] id: MT:0000083 name: ectopic cranial bone growth namespace: Trait.ontology def: "growth of extra bony structures in or near the cranium" [J:26513] synonym: "heterotopic cranial bone growth" EXACT [] is_a: MT:0000076 ! calvaria morphology [Term] id: MT:0000084 name: fontanelle morphology namespace: Trait.ontology def: "structural defect in the membranous interval at the margins of cranial bones in neonates" [J:53370, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal fontanel" EXACT [] synonym: "abnormal fontanelle" EXACT [] is_a: MT:0000076 ! calvaria morphology is_a: MT:0002113 ! skeleton development [Term] id: MT:0000085 name: blood-cerebrospinal fluid barrier morphology namespace: Trait.ontology def: "any measurable or observable characteristic related to the shape, structure, color or pattern of the group of barriers and transport systems in the choroid plexus located in the lateral, third, and fourth brain ventricles that controls the entrance of substances into the cerebrospinal fluid from the blood" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] relationship: part_of MT:0001614 ! blood vessel morphology [Term] id: MT:0000087 name: capillary morphology namespace: Trait.ontology def: "any measurable or observable characteristic related to the shape, structure, color or pattern of the minute blood vessels that connect arterioles and venules" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] xref: MP:0003658 is_a: MT:0001614 ! blood vessel morphology [Term] id: MT:0000088 name: blood vessel integrity namespace: Trait.ontology def: "any measurable characteristic pertaining to the the structural completeness or structural soundness of the tubes that carry blood through the body" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] synonym: "vascular integrity" RELATED [] relationship: part_of MT:0001614 ! blood vessel morphology [Term] id: MT:0000090 name: inferior vena cava integrity namespace: Trait.ontology def: "any measurable characteristic pertaining to the the structural completeness or structural soundness of the" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] is_a: MT:0000118 ! vein integrity relationship: part_of MT:0006063 ! inferior vena cava morphology [Term] id: MT:0000091 name: superior vena cava integrity namespace: Trait.ontology def: "any measurable characteristic pertaining to the the structural completeness or structural soundness of the" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] is_a: MT:0000118 ! vein integrity relationship: part_of MT:0006064 ! superior vena cava morphology [Term] id: MT:0000092 name: stria vascularis blood vessel integrity namespace: Trait.ontology def: "any measurable characteristic pertaining to the the structural completeness or structural soundness of the the blood vessels supplying the stria vascularis in the cochlea of the inner ear" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] synonym: "integrity of the stial vasculature" RELATED [] synonym: "stria vascularis vascular integrity" RELATED [] synonym: "strial vascular integrity" RELATED [] is_a: MT:0000088 ! blood vessel integrity relationship: part_of MT:0004368 ! stria vascularis blood vessel morphology [Term] id: MT:0000093 name: choroid blood vessel integrity namespace: Trait.ontology def: "any measurable characteristic pertaining to the the structural completeness or structural soundness of the blood vessels of the choroid" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] is_a: MT:0000088 ! blood vessel integrity relationship: part_of MT:0006237 ! choroid blood vessel morphology [Term] id: MT:0000094 name: conjunctival blood vessel integrity namespace: Trait.ontology def: "any measurable characteristic pertaining to the the structural completeness or structural soundness of the blood vessel network of the conjunctiva" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] synonym: "conjunctival vascular integrity" RELATED [] synonym: "integrity of the conjunctival vasculature" RELATED [] is_a: MT:0000088 ! blood vessel integrity relationship: part_of MT:0006192 ! conjunctival blood vessel morphology [Term] id: MT:0000097 name: retina blood vessel integrity namespace: Trait.ontology def: "any measurable characteristic pertaining to the the structural completeness or structural soundness of the blood vessels supplying the retina" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] synonym: "integrity of the retinal vasculature" RELATED [] synonym: "retinal vascular integrity" RELATED [] is_a: MT:0000088 ! blood vessel integrity relationship: part_of MT:0002792 ! retina blood vessel morphology [Term] id: MT:0000098 name: vomer bone morphology namespace: Trait.ontology def: "missing triangular flat bone of the nasal septum" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal vomer bone" EXACT [] is_a: MT:0005274 ! viscerocranium morphology [Term] id: MT:0000099 name: aotic arch integrity namespace: Trait.ontology def: "any measurable characteristic pertaining to the the structural completeness or structural soundness of the portion of the descending aorta proceeding from the arch of the aorta and extending to the diaphram" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] relationship: part_of MT:0004113 ! aortic arch morphology relationship: part_of MT:0007044 ! aorta integrity [Term] id: MT:0000100 name: ethmoidal bone morphology namespace: Trait.ontology def: "defect in the midline facial bone that encloses the nasal cavity" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal ethmoid bone" EXACT [] synonym: "abnormal ethmoidal bone" EXACT [] is_a: MT:0005273 ! cranial base morphology is_a: MT:0005552 ! orbital bone morphology [Term] id: MT:0000101 name: blood vessel elastic tissue integrity namespace: Trait.ontology def: "any measurable characteristic pertaining to the the structural completeness or structural soundness of the tissue that is found in the tunica media of the vessels wall and allows vessels to stretch" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator", RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] synonym: "vascular elastic tissue integrity" RELATED [] relationship: part_of MT:0000088 ! blood vessel integrity relationship: part_of MT:0006083 ! blood vessel elastic tissue morphology [Term] id: MT:0000102 name: nasal bone morphology namespace: Trait.ontology def: "any structural anomaly of either of two rectangular bone plates forming the bridge of the nose" [J:17489, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal nasal bone" EXACT [] is_a: MT:0005274 ! viscerocranium morphology [Term] id: MT:0000103 name: pulmonary vein integrity namespace: Trait.ontology def: "any measurable characteristic pertaining to the the structural completeness or structural soundness of the blood vessels that return oxygenated blood from the lungs to the left atrium of the heart" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] synonym: "pulmonary venous integrity" RELATED [] is_a: MT:0000118 ! vein integrity relationship: part_of MT:0002726 ! pulmonary vein morphology [Term] id: MT:0000104 name: sphenoid bone morphology namespace: Trait.ontology def: "malformed irregularly shaped bone of the base of the skull" [J:49840, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal sphenoid bone" EXACT [] is_a: MT:0005273 ! cranial base morphology is_a: MT:0005552 ! orbital bone morphology [Term] id: MT:0000105 name: ossification of basisphenoid bone namespace: Trait.ontology def: "abnormal formation of the bone at the base of the sphenoid bone; arises from an ossification center independent of the remainder of the sphenoid bone" [J:49840, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000106 ! basisphenoid bone morphology [Term] id: MT:0000106 name: basisphenoid bone morphology namespace: Trait.ontology def: "any structural anomaly of part of the base of the cranium between the basioccipital and the presphenoid, which usually ossifies separately in the embryo or in the young, and becomes a part of the sphenoid in the adult; in many animals it persists as a separate bone between the basioccipital bone and the presphenoidal bone" [J:55583, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal basisphenoid bone" EXACT [] is_a: MT:0000104 ! sphenoid bone morphology [Term] id: MT:0000107 name: frontal bone morphology namespace: Trait.ontology def: "any structural anomaly of the bone forming the forehead and roof of the eye orbit" [J:17489, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal frontal bone" EXACT [] is_a: MT:0000076 ! calvaria morphology is_a: MT:0005274 ! viscerocranium morphology is_a: MT:0005552 ! orbital bone morphology [Term] id: MT:0000108 name: midline facial cleft namespace: Trait.ontology def: "incomplete merging or fusion of the tissues normally uniting to form the face" [J:49840, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002116 ! craniofacial bone morphology [Term] id: MT:0000109 name: parietal bone morphology namespace: Trait.ontology def: "malformed curved bone forming part of the vault of the cranium" [J:17489] synonym: "abnormal parietal bone" EXACT [] is_a: MT:0000076 ! calvaria morphology [Term] id: MT:0000111 name: cleft palate namespace: Trait.ontology alt_id: MT:0000429 def: "congenital fissure of the tissues normally uniting to form the palate" [J:49840, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0003755 ! palate [Term] id: MT:0000114 name: cleft chin namespace: Trait.ontology def: "incomplete fusion of the chin; usually a fissure" [J:42035, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000458 ! mandible morphology [Term] id: MT:0000116 name: tooth development namespace: Trait.ontology def: "anomalous formation of the teeth" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "tooth development abnormalities" EXACT [] is_a: MT:0002100 ! tooth morphology is_a: MT:0002113 ! skeleton development is_a: MT:0003935 ! craniofacial development [Term] id: MT:0000117 name: tooth primordium namespace: Trait.ontology def: "missing the cells that will give rise to teeth" [J:54637, tc:Teresa Chu_Mouse Genome Informatics Curator] synonym: "absence of tooth anlage" EXACT [] synonym: "absence of tooth primordium" EXACT [] is_a: MT:0000116 ! tooth development [Term] id: MT:0000118 name: vein integrity namespace: Trait.ontology def: "any measurable characteristic pertaining to the the structural completeness or structural soundness of the blood vessels that return blood to the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] synonym: "venous integrity" RELATED [] is_a: MT:0000088 ! blood vessel integrity is_a: MT:0002725 ! vein morphology [Term] id: MT:0000119 name: tooth eruption namespace: Trait.ontology def: "anomalies in the passage of a tooth through the alveolar process and perforation of the gums" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "tooth eruption abnormalities" EXACT [] is_a: MT:0002100 ! tooth morphology [Term] id: MT:0000120 name: malocclusion namespace: Trait.ontology def: "perturbations in the normal patterned arrangement of the teeth or alignment of the jaw, resulting in the incorrect position of biting or chewing surfaces of the upper and lower teeth" [J:61509] synonym: "misaligned teeth" EXACT [] is_a: MT:0000438 ! skull morphology [Term] id: MT:0000121 name: cardiovascular development namespace: Trait.ontology def: "any measurable or observable characteristic related to the morphology or physiology of the heart or blood vessels during their formation and differentiation" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] relationship: part_of MT:0005385 ! cardiovascular system trait [Term] id: MT:0000122 name: blood vessel development namespace: Trait.ontology def: "any measurable or observable characteristic related to the morphology or physiology of the vasculature during its formation and differentiation" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] synonym: "vascular development" RELATED [] relationship: part_of MT:0000121 ! cardiovascular development [Term] id: MT:0000124 name: tooth number namespace: Trait.ontology def: "count of the bony structures of the upper and lower jaws used in mastication" [J:61295, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "absence of all teeth" EXACT [] is_a: MT:0002100 ! tooth morphology [Term] id: MT:0000125 name: heart tube morphology namespace: Trait.ontology def: "any measurable or observable characteristic related to the shape, structure, color or pattern of the early embryonic heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] relationship: part_of MT:0000267 ! heart development [Term] id: MT:0000126 name: tooth strength namespace: Trait.ontology def: "fragile and likely to break teeth" [J:61509] is_a: MT:0002100 ! tooth morphology [Term] id: MT:0000127 name: molar integrity namespace: Trait.ontology def: "atrophy of the molars" [J:61509] is_a: MT:0002689 ! molar morphology [Term] id: MT:0000128 name: growth of molars namespace: Trait.ontology def: "developmental delay of the growth of the molars" [J:17489] is_a: MT:0000116 ! tooth development [Term] id: MT:0000129 name: ameloblast integrity namespace: Trait.ontology def: "a retrogressive impairment of function or destruction of the epithelial cells of the inner later of the enamel organ of the developing tooth" [J:61509, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "degeneration of ameloblasts" EXACT [] is_a: MT:0002650 ! ameloblast morphology [Term] id: MT:0000130 name: cancellous bone morphology namespace: Trait.ontology def: "structural anomaly of bone that has a lattice-like or spongy structure" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal cancellous bone" EXACT [] synonym: "abnormal spongy bone" EXACT [] synonym: "abnormal spongy spongiosa" EXACT [] synonym: "abnormal spongy substance" EXACT [] synonym: "abnormal substantia trabecularis" EXACT [] synonym: "abnormal trabecular bone" EXACT [] is_a: MT:0003795 ! bone structure [Term] id: MT:0000131 name: long bone epiphysis morphology namespace: Trait.ontology def: "the head of a developing long bone that is separated from the shaft by the epiphyseal plate" [J:61509] synonym: "abnormal epiphysis" EXACT [] synonym: "abnormal long bone epiphysis morphology" EXACT [] is_a: MT:0002113 ! skeleton development is_a: MT:0003723 ! long bone morphology [Term] id: MT:0000132 name: epiphysis width namespace: Trait.ontology def: "wider than normal part of the long bones that initially develops from a distinct ossification center than the shaft" [J:61295, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000131 ! long bone epiphysis morphology [Term] id: MT:0000133 name: long bone metaphysis morphology namespace: Trait.ontology def: "malformed conical section of bone between the epiphysis and diaphysis of the long bones" [J:61295, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal long bone metaphysis" EXACT [] synonym: "abnormal metaphysis" EXACT [] is_a: MT:0003723 ! long bone morphology [Term] id: MT:0000134 name: cortical bone thickness namespace: Trait.ontology def: "reduced or increased width of the superficial layer of compact bone" [J:58795, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "cortical bone thickness abnormalities" EXACT [] is_a: MT:0003796 ! cortical bone morphology [Term] id: MT:0000135 name: outflow tract morphology namespace: Trait.ontology def: "any measurable or observable characteristic related to the shape, structure, color or pattern of the path through which blood exits the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] relationship: part_of MT:0002127 ! cardiovascular system morphology [Term] id: MT:0000136 name: microglial cell morphology namespace: Trait.ontology def: "anomalous structure, number, or composition of the small neuroglial cells, possibly of mesodermal origin, which may become phagocytic, in areas of neural damage or inflammation" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, J:71688] is_a: MT:0000952 ! CNS glia morphology [Term] id: MT:0000137 name: vertebrae morphology namespace: Trait.ontology alt_id: MT:0001538 def: "malformed bony segment of the spinal column" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] subset: slim_cattle subset: slim_pig synonym: "abnormal vertebrae" EXACT [] synonym: "vertebra defect" EXACT [] is_a: MT:0002114 ! axial skeleton morphology [Term] id: MT:0000138 name: vertebrae number namespace: Trait.ontology def: "missing bony segments of the spinal column" [J:35802] subset: slim_cattle subset: slim_pig synonym: "absence of vertebrae" EXACT [] is_a: MT:0000137 ! vertebrae morphology [Term] id: MT:0000139 name: transverse process morphology namespace: Trait.ontology def: "form or structure of the bony protrusion on either side of the arch of a thoracic vertebrae" [J:62022, J:62023] synonym: "absence of transverse processes" EXACT [] is_a: MT:0000137 ! vertebrae morphology [Term] id: MT:0000140 name: pedicle morphology namespace: Trait.ontology def: "form or structure of part of the posteriorlateral vertebral arch of a thoracic vertebrae" [J:62022, J:62023] is_a: MT:0000137 ! vertebrae morphology [Term] id: MT:0000141 name: vertebral body morphology namespace: Trait.ontology def: "malformed main portion of the vertebra anterior to the vertebral canal" [J:55583, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal vertebral bodies" EXACT [] is_a: MT:0000137 ! vertebrae morphology [Term] id: MT:0000142 name: ear thickness namespace: Trait.ontology def: "straight line distance from the exterior surface to the interior surface of the outer ear" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0000017 ! ear size [Term] id: MT:0000143 name: immature B cell number namespace: Trait.ontology def: "number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0005022 ! immature B cell morphology/development [Term] id: MT:0000148 name: shoulder/ pelvic girdle morphology namespace: Trait.ontology alt_id: MT:0001540 def: "anomalous structure of the bones of the shoulder or of the bones of the pelvis by which the limbs attach to the axial skeleton " [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal shoulder/ pelvic girdle" EXACT [] synonym: "shoulder/ pelvic girdle defect" EXACT [] is_a: MT:0005508 ! skeleton morphology [Term] id: MT:0000149 name: scapula morphology namespace: Trait.ontology def: "malformation of either or both of the large, flat bones of the back part of the shoulder" [J:13049] synonym: "abnormal scapula" EXACT [] is_a: MT:0000148 ! shoulder/ pelvic girdle morphology [Term] id: MT:0000150 name: rib morphology namespace: Trait.ontology def: "malformed bones forming the bony wall of the chest" [J:50311, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal ribs" EXACT [] synonym: "rib defect" EXACT [] is_a: MT:0002114 ! axial skeleton morphology [Term] id: MT:0000151 name: atrioventricular canal partioning namespace: Trait.ontology def: "any measurable or observable characteristic related to the process by which the right and left sides of the heart become separated" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] relationship: part_of MT:0000267 ! heart development [Term] id: MT:0000152 name: proximal rib morphology namespace: Trait.ontology def: "missing part of rib structures near the spine, ribs do not contact vertebrae" [J:62022, J:62023] is_a: MT:0000150 ! rib morphology [Term] id: MT:0000155 name: rib attachment namespace: Trait.ontology def: "pattern, form, or structure of rib attachments to the vertebral column or to the sternum" [J:19212] is_a: MT:0000150 ! rib morphology [Term] id: MT:0000156 name: memory B cell number namespace: Trait.ontology def: "number of cells of the B lymphocyte lineage that do not secrete antibody after an initial contact with antigen, but can be rapidly activated after a second challenge with the same antigen" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0002440 ! memory B cell morphology/development [Term] id: MT:0000157 name: sternum morphology namespace: Trait.ontology def: "malformed long flat bone of the chest; articulates with clavicle and first seven rib pairs" [J:19212, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal sternum" EXACT [] synonym: "sternum defect" EXACT [] is_a: MT:0002114 ! axial skeleton morphology [Term] id: MT:0000159 name: xiphoid process morphology namespace: Trait.ontology def: "malformed posterior tip of the sternum" [J:42932, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "xiphoid process defect" EXACT [] is_a: MT:0000157 ! sternum morphology [Term] id: MT:0000160 name: kyphosis namespace: Trait.ontology alt_id: MT:0000068 def: "forward curvature of the spine, characterized by extensive flexion. " [cml:Cathleen M. Lutz_Mouse Genome Informatics Curator, J:62023, J:66943, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "humpback" EXACT [] synonym: "hunchback" EXACT [] is_a: MT:0004174 ! spine curvature [Term] id: MT:0000161 name: scoliosis namespace: Trait.ontology alt_id: MT:0000070 def: "lateral and rotational curvature of the spine" [J:53770, J:66943, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0004174 ! spine curvature [Term] id: MT:0000162 name: lordosis namespace: Trait.ontology def: "anteriorly convex curvature of the spine, \"saddle back\" " [J:62022, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0004174 ! spine curvature [Term] id: MT:0000163 name: cartilage morphology namespace: Trait.ontology def: "anomalous structure or development of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the thorax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal cartilage" EXACT [] is_a: MT:0005508 ! skeleton morphology [Term] id: MT:0000164 name: cartilage development namespace: Trait.ontology def: "anomalous formation of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the thorax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal cartilage formation" EXACT [] is_a: MT:0000163 ! cartilage morphology is_a: MT:0002113 ! skeleton development [Term] id: MT:0000165 name: hypertrophic chondrocyte zone morphology namespace: Trait.ontology def: "anomaly of the cartilage cell matrix layer " [J:58795, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000164 ! cartilage development is_a: MT:0003055 ! epiphyseal plate morphology [Term] id: MT:0000166 name: chondrocyte morphology namespace: Trait.ontology def: "anomalous structure, organization, or differentiation of nondividing cartilage cells" [J:40203, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal chondrocytes" EXACT [] is_a: MT:0000163 ! cartilage morphology [Term] id: MT:0000167 name: chondrocyte number namespace: Trait.ontology def: "fewer than normal numbers of nondividing cartilage cells" [J:61509, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000166 ! chondrocyte morphology [Term] id: MT:0000168 name: bone marrow development namespace: Trait.ontology def: "malformation or anomalous differentiation of the soft, pulpy tissue filling the medullary cavities of bones" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal bone marrow formation/ structure" EXACT [] is_a: MT:0002113 ! skeleton development [Term] id: MT:0000172 name: bone marrow cell number namespace: Trait.ontology def: "increased or decreased number of cells that make up the core cavities of bones when compared to controls" [tc:Teresa Chu_Mouse Genome Informatics Curator] is_a: MT:0002398 ! bone marrow cell morphology/development [Term] id: MT:0000176 name: bone marrow occupied by adipocytes namespace: Trait.ontology def: "anomalous appearance of fat-forming cells in the bone marrow" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] is_a: MT:0000168 ! bone marrow development [Term] id: MT:0000179 name: blood chemistry namespace: Trait.ontology alt_id: MT:0001546 def: "anomalous concentrations of proteins, minerals, nutrients, gases, or other substances in the blood" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] subset: slim_cattle subset: slim_chkn subset: slim_pig synonym: "blood chemistry abnormalities" EXACT [] is_a: MT:0005428 ! clinical chemistry [Term] id: MT:0000180 name: circulating cholesterol level namespace: Trait.ontology def: "anomalous concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] subset: slim_chkn synonym: "abnormal cholesterol level" EXACT [] is_a: MT:0003947 ! cholesterol level is_a: MT:0003949 ! circulating lipid level [Term] id: MT:0000181 name: circulating LDL cholesterol level namespace: Trait.ontology def: "anomalous concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal LDL cholesterol level" EXACT [] is_a: MT:0000180 ! circulating cholesterol level [Term] id: MT:0000184 name: circulating HDL cholesterol level namespace: Trait.ontology alt_id: MT:0001555 def: "anomalous concentration in the blood of high density lipoprotein; this molecule transports cholesterol to the liver for excretion in bile" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal HDL cholesterol level" EXACT [] synonym: "Abnormal HDL Levels" EXACT [] is_a: MT:0000180 ! circulating cholesterol level [Term] id: MT:0000187 name: triglyceride level namespace: Trait.ontology alt_id: MT:0001551 def: "anomalous concentration of this molecule, glycerol esterified at each of its three hydroxyl groups by a fatty acid; triglyceride is an important molecule for storage of fatty acids in adipose tissue" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] subset: slim_chkn synonym: "abnormal triacylglycerol level" EXACT [] is_a: MT:0001547 ! lipid level [Term] id: MT:0000188 name: circulating glucose level namespace: Trait.ontology alt_id: MT:0001557 def: "anomalous concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] subset: slim_chkn subset: slim_pig synonym: "abnormal blood glucose level" EXACT [] is_a: MT:0002078 ! glucose homeostasis [Term] id: MT:0000192 name: mineral level namespace: Trait.ontology alt_id: MT:0001561 def: "anomalous concentration of any inorganic substance that has importance in body functions" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0005636 ! mineral homeostasis [Term] id: MT:0000199 name: circulating albumin level namespace: Trait.ontology alt_id: MT:0001568 def: "aberrant concentration in the blood of this most abundant of the plasma proteins " [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "abnormal albumin level" EXACT [] synonym: "analbuminemia" EXACT [] is_a: MT:0005416 ! circulating protein level [Term] id: MT:0000202 name: circulating alkaline phosphatase level namespace: Trait.ontology alt_id: MT:0001571 def: "anomalous concentration in the blood of this enzyme, which hydrolyzes orthophosphoric monoesters; low levels are seen in cases of hypophosphatasia" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal alkaline phosphatase activity" EXACT [] synonym: "abnormal alkaline phosphatase level" EXACT [] synonym: "abnormal AP level" EXACT [] synonym: "abnormal circulating ALP levels" EXACT [] xref: GO:0004035 is_a: MT:0001570 ! circulating enzyme level [Term] id: MT:0000203 name: circulating aspartate transaminase level namespace: Trait.ontology alt_id: MT:0001572 def: "anomalous concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal aspartate aminotransferase level" EXACT [] synonym: "abnormal aspartate transaminase level" EXACT [] synonym: "abnormal AST level" EXACT [] is_a: MT:0001570 ! circulating enzyme level [Term] id: MT:0000217 name: white blood cell count namespace: Trait.ontology alt_id: MT:0001587 def: "anomalies in the number of leukocytes" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] subset: slim_cattle subset: slim_pig synonym: "abnormal WBC cell" EXACT [] synonym: "abnormal white blood cell number" EXACT [] synonym: "leukocyte count abnormalities" EXACT [] synonym: "white blood cell count abnormalities" EXACT [] synonym: "white blood cell number abnormalities" EXACT [] is_a: MT:0000716 ! immune system cell morphology is_a: MT:0002429 ! blood cell morphology/development [Term] id: MT:0000221 name: WBC count namespace: Trait.ontology def: "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] subset: slim_cattle subset: slim_pig synonym: "decreased leukocyte count" EXACT [] synonym: "decreased WBC number" EXACT [] synonym: "leukocytopenia" EXACT [] synonym: "leukopenia" EXACT [] synonym: "lymphopenia" EXACT [] is_a: MT:0000217 ! white blood cell count [Term] id: MT:0000222 name: neutrophil count namespace: Trait.ontology def: "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] subset: slim_pig synonym: "decreased neutrophil number" EXACT [] synonym: "neutropenia" EXACT [] synonym: "segmented neutrophil count" EXACT [] is_a: MT:0000334 ! granulocyte number is_a: MT:0002415 ! neutrophil morphology/development [Term] id: MT:0000223 name: monocyte count namespace: Trait.ontology def: "fewer than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "decreased monocyte number" EXACT [] synonym: "monocytopenia" EXACT [] is_a: MT:0000221 ! WBC count is_a: MT:0002620 ! monocyte morphology/development [Term] id: MT:0000226 name: mean corpuscular volume namespace: Trait.ontology alt_id: MT:0001590 def: "deviation from normal for the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] comment: MCV is calculated by dividing the hematocrit by the total number of RBCs and multiplying this number by ten (10). This was found on medfriendly.com. cwg 3/10/03 subset: slim_chkn synonym: "abnormal MCV" EXACT [] synonym: "abnormal mean cell volume" EXACT [] is_a: MT:0002124 ! red blood cell [Term] id: MT:0000228 name: thrombopoiesis namespace: Trait.ontology alt_id: MT:0000211 alt_id: MT:0000227 alt_id: MT:0001583 alt_id: MT:0001591 alt_id: MT:0001592 alt_id: MT:0002448 def: "abnormal development of the non-nucleated cells of the blood (platelets, thrombocytes) involved in blood coagulation" [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal platelet development" EXACT [] synonym: "abnormal platelet morphology/development" EXACT [] synonym: "abnormal platelets" EXACT [] synonym: "platelet abnormalities" EXACT [] synonym: "platelet development abnormalities" EXACT [] synonym: "thrombocyte abnormalities" EXACT [] is_a: MT:0002123 ! hematopoiesis is_a: MT:0002417 ! megakaryocyte morphology/development [Term] id: MT:0000229 name: megakaryocyte differentiation namespace: Trait.ontology alt_id: MT:0001593 def: "atypical process of formation and development these very large bone marrow cells which release mature platelets" [MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0000228 ! thrombopoiesis [Term] id: MT:0000230 name: blood pressure namespace: Trait.ontology alt_id: MT:0001594 alt_id: MT:0002129 def: "any measurable characteristic of the tension of the blood within the systemic arteries" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] xref: MGI:2173589 is_a: MT:0001544 ! cardiovascular system physiology [Term] id: MT:0000233 name: blood flow velocity namespace: Trait.ontology alt_id: MT:0001597 def: "rate of flow of the blood through vessels" [ms:mary shimoyama] is_a: MT:0002128 ! blood circulation [Term] id: MT:0000237 name: blood cell number namespace: Trait.ontology def: "fewer than the normal numbers of the various types of blood cells" [J:60630] synonym: "reduction in hematopoietic cell types" EXACT [] synonym: "reduction in hemopoietic cell types" EXACT [] is_a: MT:0002123 ! hematopoiesis [Term] id: MT:0000239 name: myeloid colony forming progenitor cell number namespace: Trait.ontology def: "lack of precursors of the myeloid cell types" [J:60630, tc:Teresa Chu_Mouse Genome Informatics Curator] is_a: MT:0002123 ! hematopoiesis [Term] id: MT:0000240 name: extramedullary hematopoiesis namespace: Trait.ontology def: "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "EMH" EXACT [] synonym: "extramedullary hemopoiesis" EXACT [] is_a: MT:0002123 ! hematopoiesis [Term] id: MT:0000243 name: myoclonus namespace: Trait.ontology def: "involuntary shock-like contractions, variable in rhythm and amplitude, followed by relaxation, of a muscle or a group of muscles; generally due to a central nervous system lesion" [MeSH:National Library of Medicine_Medical Subject Headings, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000743 ! muscle spasms [Term] id: MT:0000245 name: erythropoiesis namespace: Trait.ontology alt_id: MT:0001608 def: "atypical process of red blood cell formation" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8, tc:Teresa Chu_Mouse Genome Informatics Curator] subset: slim_cattle subset: slim_chkn synonym: "abnormal erythrocytopoiesis" EXACT [] synonym: "erythropoiesis abnormalities" EXACT [] is_a: MT:0002123 ! hematopoiesis [Term] id: MT:0000247 name: IL-10 physiology namespace: Trait.ontology def: "functional anomaly of this factor that is a co-regulator of mast cell growth and produced by T and B cells" [MeSH:National Library of Medicine_Medical Subject Headings, pvb:Pierre Vanden Borre_Mouse Genome Informatics Curator] synonym: "interleukin 10" EXACT [] is_a: MT:0002529 ! interleukin physiology [Term] id: MT:0000248 name: macrocytosis namespace: Trait.ontology alt_id: MT:0001610 def: "condition in which erythrocytes are larger than normal in size" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "macrocythemia" EXACT [] synonym: "megalocythemia" EXACT [] synonym: "megalocytosis" EXACT [] synonym: "megaolcytosis" EXACT [] is_a: MT:0002447 ! erythrocyte morphology [Term] id: MT:0000249 name: blood vessel physiology namespace: Trait.ontology synonym: "vascular physiology" EXACT [] is_a: MT:0001544 ! cardiovascular system physiology [Term] id: MT:0000250 name: vasoconstriction namespace: Trait.ontology alt_id: MT:0001612 def: "narrowing of the blood vessels" [ISBN:0-683-40008-8 "Stedman's Medical Dictionary, 27th edition"] is_a: MT:0000249 ! blood vessel physiology [Term] id: MT:0000253 name: plasma cell number namespace: Trait.ontology def: "number of the specialized forms of B-lymphocytes which produce and secrete immunoglobulin" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0002439 ! plasma cell morphology/development [Term] id: MT:0000254 name: cerebrospinal fluid volume namespace: Trait.ontology def: "amount of the serumlike fluid that circulates through the ventricles of the brain, the cavity of the spinal cord, and the subarachnoid space, functioning in shock absorption." [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0003632 ! nervous system morphology [Term] id: MT:0000256 name: echinocytosis namespace: Trait.ontology def: "a state in which the red blood cells have multiple small projections appearing over the cell circumference resembling a small burr or a sea urchin" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, J:82330, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "burr erythrocyte" EXACT [] synonym: "crenation" EXACT [] synonym: "echinosis" EXACT [] is_a: MT:0002447 ! erythrocyte morphology [Term] id: MT:0000266 name: cardiac morphology namespace: Trait.ontology alt_id: MT:0000271 def: "any measurable or observable characteristic related to the shape, structure, color or pattern of the organ that pumps blood through the body" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] subset: slim_chkn subset: slim_pig synonym: "heart morphology" RELATED [] xref: GO:0007505 xref: MP:0000266 is_a: MT:0002127 ! cardiovascular system morphology [Term] id: MT:0000267 name: heart development namespace: Trait.ontology alt_id: MT:0001624 def: "any measurable or observable characteristic related to the morphology or physiology of the heart during its formation and differentiation" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] synonym: "cardiac development" EXACT [] xref: GO:0007507 xref: MP:0000267 relationship: part_of MT:0000121 ! cardiovascular development [Term] id: MT:0000268 name: vibrissae number namespace: Trait.ontology def: "number of whiskers" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0002098 ! vibrissae morphology [Term] id: MT:0000269 name: heart tube looping morphogenesis namespace: Trait.ontology def: "any measurable or observable characteristics pertaining to the process by which the embryonic heart tube bends to transform from a straight tube into the final folded configuration of the adult heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] synonym: "cardiac looping morphogenesis" RELATED [] relationship: part_of MT:0000267 ! heart development [Term] id: MT:0000270 name: heart tube integrity namespace: Trait.ontology def: "any measurable characteristic pertaining to the structural completeness or structural soundness of the early embryonic heart" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] relationship: part_of MT:0000125 ! heart tube morphology [Term] id: MT:0000272 name: aorta morphology namespace: Trait.ontology def: "any measurable or observable characteristic related to the shape, structure, color or pattern of the main trunk of the systemic arteries" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] xref: MP:0000272 is_a: MT:0002191 ! artery morphology [Term] id: MT:0000276 name: right ventricle cell size namespace: Trait.ontology def: "the physical dimensions, proportions, magnitude, or extent of the cells in the right lower chamber of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] synonym: "right ventricular cell size" RELATED [] is_a: MT:0001625 ! heart cell size relationship: part_of MT:0003920 ! right ventricle morphology [Term] id: MT:0000277 name: heart shape namespace: Trait.ontology def: "any measurable or observable characterisic of the form of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] synonym: "cardiac shape" EXACT [] relationship: part_of MT:0000266 ! cardiac morphology [Term] id: MT:0000278 name: heart muscle fiber integrity namespace: Trait.ontology alt_id: MT:0002994 def: "any measurable characteristic pertaining to the the structural completeness or structural soundness of the multinucleated muscle cells of the heart" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] synonym: "cardiac muscle fiber integrity" RELATED [] synonym: "myocardial fiber integrity" RELATED [] relationship: part_of MT:0000061 ! heart muscle fiber morphology relationship: part_of MT:0000073 ! heart muscle integrity relationship: part_of MT:0004087 ! muscle fiber morphology [Term] id: MT:0000281 name: ventricle septum integrity namespace: Trait.ontology alt_id: MT:0005484 def: "any measurable characteristic pertaining to the the structural completeness or structural soundness of the wall between the two lower chambers of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] synonym: "interventricular septum integrity" RELATED [] synonym: "ventricular septal morphology" RELATED [] xref: MP:0000281 relationship: part_of MT:0000053 ! heart integrity relationship: part_of MT:0007082 ! ventricle septum morphology [Term] id: MT:0000282 name: atrium septum integrity namespace: Trait.ontology def: "any measurable characteristic pertaining to the the structural completeness or structural soundness of the wall between the two upper chambers of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator", RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] synonym: "atrial septal integrity" RELATED [] relationship: part_of MT:0000053 ! heart integrity relationship: part_of MT:0007081 ! atrium septum morphology [Term] id: MT:0000284 name: right ventricle integrity namespace: Trait.ontology alt_id: MT:0000283 def: "any measurable characteristic pertaining to the the structural completeness or structural soundness of the right lower chamber of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] relationship: part_of MT:0000053 ! heart integrity relationship: part_of MT:0003920 ! right ventricle morphology [Term] id: MT:0000285 name: heart valve morphology namespace: Trait.ontology def: "any measurable or observable characteristic related to the shape, structure, color or pattern of the membranous folds of the heart that prevent reflux of fluid" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] synonym: "cardiac valve morphology" RELATED [] xref: MP:0000285 relationship: part_of MT:0000266 ! cardiac morphology [Term] id: MT:0000286 name: mitral valve integrity namespace: Trait.ontology def: "any measurable characteristic pertaining to the the structural completeness or structural soundness of the valve between the left atrium and the left ventricle of the heart" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] is_a: MT:0002745 ! atrioventricular valve integrity relationship: part_of MT:0000033 ! mitral valve morphology [Term] id: MT:0000288 name: pericardium morphology namespace: Trait.ontology def: "any measurable or observable characteristic related to the shape, structure, color or pattern of the fibroserous membrane covering the heart and beginning of the great vessels" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] synonym: "pericardial morphology" EXACT [] xref: GO:0007513 relationship: part_of MT:0000266 ! cardiac morphology [Term] id: MT:0000297 name: endocardial cushion integrity namespace: Trait.ontology def: "any measurable characteristic pertaining to the structural completeness or structural soundness of the mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal; these mounds fuse to form the valves between the right and left atrioventricular orifices" [ISBN:0-683-40008-8 "Stedman's Medical Dictionary, 27th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] xref: GO:0007505 relationship: part_of MT:0007001 ! endocardial cushion morphology [Term] id: MT:0000304 name: cardiac stroke volume namespace: Trait.ontology alt_id: MT:0001628 def: "amount of blood pushed into the aorta with each beat of the heart" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] is_a: MT:0002128 ! blood circulation [Term] id: MT:0000306 name: umbilical artery integrity namespace: Trait.ontology def: "any measurable characteristic pertaining to the the structural completeness or structural soundness of the blood vessel of the umbilical cord" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] is_a: MT:0001725 ! umbilical cord morphology is_a: MT:0003410 ! artery integrity [Term] id: MT:0000307 name: blood-inner ear barrier function namespace: Trait.ontology def: "function of the group of barriers and transport systems which regulate the transport of various substances from blood to inner ear tissue and maintain the microhomeostasis and functional integrity of the inner ear; the endothelial cells of the inner ear blood capillaries, linked to each other by tight junctions, represent the main component of the blood-inner ear barrier" [MGI:anna "Anna Anagnostopoulos, Mouse Genome Informatics Curator"] is_a: MT:0000249 ! blood vessel physiology is_a: MT:0003878 ! ear physiology [Term] id: MT:0000313 name: cell death namespace: Trait.ontology alt_id: MT:0001647 def: "anomalous cessation of function at the cellular level" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal cellular death" EXACT [] is_a: MT:0005621 ! cell physiology [Term] id: MT:0000314 name: schistocytosis namespace: Trait.ontology def: "the appearance of poikilocytes in the blood that owe their abnormal shape to fragmentation occurring as the cells flow through damaged small vessels" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, J:82330] synonym: "schizocytosis" EXACT [] is_a: MT:0002643 ! poikilocytosis [Term] id: MT:0000315 name: urine hemoglobin level namespace: Trait.ontology def: "the presence of hemoglobin in the urine, including certain closely related pigments that are formed from slight alteration of the hemoglobin molecule" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, J:82330] synonym: "hemoglobinuria" RELATED [] is_a: MT:0005160 ! urine protein level [Term] id: MT:0000316 name: cellular necrosis namespace: Trait.ontology def: "pathologic death of cells, usually from irreversible damage" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001651 ! necrosis [Term] id: MT:0000317 name: cell number namespace: Trait.ontology def: "anomalous numbers of cells" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] is_a: MT:0005384 ! cellular trait [Term] id: MT:0000319 name: endolymph physiology namespace: Trait.ontology def: "processes involved in the production (volume) or ionic homeostasis of the fluid contained within the membranous labyrinth of the inner ear" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0003878 ! ear physiology [Term] id: MT:0000327 name: hemosiderinuria namespace: Trait.ontology def: "the presence of hemosiderin in the urine; hemosiderin is an intracellular storage form of iron, found in the form of pigmented yellow to brown granules consisting of a complex of ferric hydroxides, polysaccharides, and proteins with an iron content of about 33 per cent by weight" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, J:82330] is_a: MT:0001757 ! urine chemistry [Term] id: MT:0000330 name: endolymph production namespace: Trait.ontology def: "secretion of the fluid that is normally contained within the membranous labyrinth of the inner ear" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0000319 ! endolymph physiology [Term] id: MT:0000332 name: hemoglobinemia namespace: Trait.ontology def: "the presence of free hemoglobin in the blood plasma, an indication of significant intravascular hemolysis" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, J:82330] is_a: MT:0005416 ! circulating protein level [Term] id: MT:0000334 name: granulocyte number namespace: Trait.ontology alt_id: MT:0000723 def: "fewer than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] subset: slim_pig synonym: "decreased granulocyte number" EXACT [] synonym: "granulocytopenia" EXACT [] is_a: MT:0000221 ! WBC count is_a: MT:0002441 ! granulocyte morphology/development [Term] id: MT:0000336 name: mast cell number namespace: Trait.ontology def: "fewer than expected number of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] is_a: MT:0000359 ! mast cell morphology is_a: MT:0002607 ! basophil count [Term] id: MT:0000340 name: perilymph physiology namespace: Trait.ontology def: "production (volume) or ionic homeostasis of the fluid contained within the osseous labyrinth, surrounding and protecting the membranous labyrinth" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0003878 ! ear physiology [Term] id: MT:0000341 name: bile color namespace: Trait.ontology def: "a change in the color of the bile from the normal yellowish brown or green " [J:80519] is_a: MT:0005085 ! gall bladder physiology [Term] id: MT:0000344 name: Cajal-Retzius cell morphology namespace: Trait.ontology alt_id: MT:0000793 alt_id: MT:0000817 def: "structure of the distinct population of large, bipolar cells, distributed in a continuous band along the marginal zone of the cortex extending to the molecular layer of the dentate gyrus" [J:60896, tc:Teresa Chu_Mouse Genome Informatics Curator] is_a: MT:0000792 ! cortical marginal zone morphology is_a: MT:0000812 ! dentate gyrus morphology is_a: MT:0002882 ! neuron [Term] id: MT:0000348 name: aerobic fitness namespace: Trait.ontology def: "any change in the metabolism resulting in an altered ability to do physical work; for example, alterations in running capacity" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, RGD:Rat Genome Database submission] is_a: MT:0002121 ! metabolism [Term] id: MT:0000350 name: cell proliferation namespace: Trait.ontology def: "anomalous growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0005621 ! cell physiology [Term] id: MT:0000353 name: vestibular system physiology namespace: Trait.ontology def: "processes pertinent to the function of he sensory system responsible for the sense of head position and movement of the body through space" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0003878 ! ear physiology [Term] id: MT:0000354 name: linear vestibular evoked potential namespace: Trait.ontology def: "biphasic response elicited by linear acceleration transients (usually jerk pulses to an animal's head); normally, this response is measured by electrophysiological activity of the peripheral vestibular nerve; this assesses the function of the gravity receptor system including the utricles and saccules of the inner ear" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] synonym: "linear vestibular compound action potentials" RELATED [] synonym: "VeSPs" RELATED [] is_a: MT:0000353 ! vestibular system physiology [Term] id: MT:0000355 name: vestibular evoked myogenic potential namespace: Trait.ontology def: "biphasic response elicited by loud clicks or tone bursts recorded from the tonically contracted sternocleidomastoid muscle; normally, acoustic stimulation of the saccule gives rise to a vestibulocollic reflex, the output of which can be measured in the neck as inhibition of activity in the ipsilateral sternocleidomastoid muscle; VEMP testing provides diagnostic information about saccular and/or inferior vestibular nerve function (assessment of balance disorders)" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] synonym: "VEMP(s)" RELATED [] is_a: MT:0000353 ! vestibular system physiology [Term] id: MT:0000356 name: vestibulocollic reflex namespace: Trait.ontology is_a: MT:0000353 ! vestibular system physiology is_a: MT:0001961 ! reflex [Term] id: MT:0000357 name: limb number namespace: Trait.ontology def: "average count of limbs" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0002109 ! limb morphology [Term] id: MT:0000358 name: cell content/ morphology namespace: Trait.ontology alt_id: MT:0000311 alt_id: MT:0000312 def: "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal cell" EXACT [] synonym: "cell abnormalities" EXACT [] synonym: "cellular abnormalities" EXACT [] is_a: MT:0005384 ! cellular trait [Term] id: MT:0000359 name: mast cell morphology namespace: Trait.ontology def: "anomalous structure of these granulated cells found in most tissues, but most abundantly in skin and gastrointestinal tract" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0005462 ! mast cell morphology/development [Term] id: MT:0000360 name: metachromatic granule number namespace: Trait.ontology def: "count of intracellular storage compartments that stain a different color than that of the dye used" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000359 ! mast cell morphology [Term] id: MT:0000361 name: mast cell protease content namespace: Trait.ontology def: "decreased amounts of proteolytic enzymes stored in mast cells" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "reduced storage of mast-cell proteases" EXACT [] is_a: MT:0000359 ! mast cell morphology [Term] id: MT:0000362 name: histamine content namespace: Trait.ontology def: "decreased amounts of this potent vasoactive peptide stored in mast cells" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "reduced storage of histamine" EXACT [] is_a: MT:0000359 ! mast cell morphology [Term] id: MT:0000363 name: cochlear microphonics namespace: Trait.ontology def: "bioelectric potentials produced by the hair cells of the organ of Corti in response to sound; the cochlear microphonic (CM) is an electric response dominated by OHC receptor potentials from the basal turn of the cochlea and provides a measure of transducer function in OHCs; in an active ear, CM waveforms show post-stimulus ringing (i.e. a cochlear echo) whereas in a passive ear system, CM decays at the cessation of the tone burst" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0004412 ! cochlear potential is_a: MT:0004434 ! cochlear outer hair cell physiology [Term] id: MT:0000365 name: hearing electrophysiology namespace: Trait.ontology def: "auditory function as it relates to electrical phenomena" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0002104 ! hearing physiology [Term] id: MT:0000366 name: brainstem auditory evoked potential namespace: Trait.ontology def: "the electrical activity generated in response to short tone bursts; may be used to evaluate sensorineural hearing function" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] synonym: "ABRs" RELATED [] synonym: "BAEPs" RELATED [] synonym: "brainstem evoked responses" RELATED [] is_a: MT:0000365 ! hearing electrophysiology is_a: MT:0000483 ! sensorineural hearing function [Term] id: MT:0000367 name: coat/ hair morphology namespace: Trait.ontology def: "anomalous color, structure, growth, or texture of the hair" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] subset: slim_cattle subset: slim_pig synonym: "abnormal coat/ hair" EXACT [] synonym: "coat/ hair abnormalities" EXACT [] synonym: "coat/ hair anomalies" EXACT [] is_a: MT:0005393 ! skin/coat/nails/feathers trait [Term] id: MT:0000370 name: head blaze namespace: Trait.ontology def: "the appearance of a stripe of white fur on the head" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0002075 ! coat color [Term] id: MT:0000372 name: irregular coat pigmentation namespace: Trait.ontology def: "uneven coloration of the hair" [J:65030] is_a: MT:0002075 ! coat color [Term] id: MT:0000373 name: belly spot namespace: Trait.ontology def: "the appearance of a round area of white fur on the belly" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0002938 ! white spotting [Term] id: MT:0000374 name: cochlear frequency tuning namespace: Trait.ontology def: "the frequency resolution of the cochlea, normally determined by the passive mechanical properties of the basilar membrane and active feedback from the outer hair cells which detect and amplify sound-induced basilar membrane motions" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] synonym: "cochlear tuning" RELATED [] synonym: "frequency resolution of the cochlea" RELATED [] is_a: MT:0000365 ! hearing electrophysiology is_a: MT:0000483 ! sensorineural hearing function [Term] id: MT:0000375 name: hair follicle structure namespace: Trait.ontology def: "anomalies of the basic architecture of the invagination of the epidermis from which the hair shaft develops" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "hair follicle structure abnormalities" EXACT [] is_a: MT:0002076 ! hair follicle structure/orientation [Term] id: MT:0000376 name: folliculitis namespace: Trait.ontology def: "inflammatory reaction in hair follicles " [J:65146, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001846 ! tissue specific inflammatory response is_a: MT:0002076 ! hair follicle structure/orientation [Term] id: MT:0000379 name: hair follicle number namespace: Trait.ontology def: "number of the epidermal invaginations from which the hair shaft develops" [J:15108] is_a: MT:0002076 ! hair follicle structure/orientation [Term] id: MT:0000382 name: hair follicle differentiation namespace: Trait.ontology def: "arrest of or retarded differentiation of the epidermal invaginations from which the hair shaft develops" [J:61790, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000375 ! hair follicle structure [Term] id: MT:0000383 name: hair follicle orientation namespace: Trait.ontology def: "misaligned hair follicles; hair follicles that do not orient in a typical pattern" [J:47620] is_a: MT:0002076 ! hair follicle structure/orientation [Term] id: MT:0000384 name: hair follicle pattern namespace: Trait.ontology def: "twisted or contorted configuration of the arrangement of hair follicles in the skin" [J:56777] is_a: MT:0002076 ! hair follicle structure/orientation [Term] id: MT:0000385 name: hair follicle size namespace: Trait.ontology def: "follicles that have swollen or expanded from the skin" [J:53379] is_a: MT:0000375 ! hair follicle structure [Term] id: MT:0000386 name: hair follicle root sheath morphology namespace: Trait.ontology def: "anomalies of the epidermally derived layer surrounding the hair follicle; innermost of two layers" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "hair follicle root sheath abnormalities" EXACT [] is_a: MT:0000375 ! hair follicle structure [Term] id: MT:0000387 name: inner root sheath cell organization namespace: Trait.ontology def: "disordered enveloping layer of cells of the hair follicle; comprises the cuticle of the inner roots" [J:56777] is_a: MT:0000386 ! hair follicle root sheath morphology [Term] id: MT:0000389 name: outer root sheath cell organization namespace: Trait.ontology def: "disordered enveloping layer of cells of the hair follicle; surrounds inner root and is continuous with basal and spinous layers of the epidermis" [J:56777] is_a: MT:0000386 ! hair follicle root sheath morphology [Term] id: MT:0000390 name: matrix sheath cell organization namespace: Trait.ontology def: "disordered layer of matrix cells of the hair follicle" [J:56777] is_a: MT:0000386 ! hair follicle root sheath morphology [Term] id: MT:0000391 name: onset of hair follicle generation namespace: Trait.ontology def: "early onset of hair follicle development" [J:39752] is_a: MT:0002076 ! hair follicle structure/orientation [Term] id: MT:0000393 name: persistent hair follicle morphogenesis namespace: Trait.ontology def: "continuous induction of de novo hair follicles in the epidermis" [J:51296] is_a: MT:0002076 ! hair follicle structure/orientation [Term] id: MT:0000394 name: hair follicle melanin granule number namespace: Trait.ontology def: "count of the pigment polymers in the hair follicles" [J:18378] is_a: MT:0005072 ! hair follicle melanin granule morphology [Term] id: MT:0000395 name: hair types namespace: Trait.ontology def: "malformed subsets of types of hairs" [J:47620] is_a: MT:0000367 ! coat/ hair morphology [Term] id: MT:0000396 name: curvature of hairs namespace: Trait.ontology def: "distinct C- or S- shaped curvature of the hairs" [J:4606] is_a: MT:0000395 ! hair types [Term] id: MT:0000397 name: guard hair morphology namespace: Trait.ontology def: "anomalies of truncal hairs that contain two air cells in the medulla" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] is_a: MT:0000395 ! hair types [Term] id: MT:0000398 name: splitting of guard hairs namespace: Trait.ontology def: "intercellular splits and kinks within or along the hair shaft of the longest and straightest of the four hair types" [J:50844] is_a: MT:0000397 ! guard hair morphology [Term] id: MT:0000399 name: curvature of guard hairs namespace: Trait.ontology def: "greater bending arch of the guard hairs" [J:47620] is_a: MT:0000396 ! curvature of hairs is_a: MT:0000397 ! guard hair morphology [Term] id: MT:0000400 name: awl hair morphology namespace: Trait.ontology def: "anomalies of truncal hairs that contain two or more air cells in the medulla" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] is_a: MT:0000395 ! hair types [Term] id: MT:0000401 name: curvature of awl hairs namespace: Trait.ontology def: "greater bending arch of the awl hairs" [J:47620] is_a: MT:0000396 ! curvature of hairs is_a: MT:0000400 ! awl hair morphology [Term] id: MT:0000402 name: zigzag hair morphology namespace: Trait.ontology def: "anomalies of truncal hairs that contain one air cell in the medulla" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] is_a: MT:0000395 ! hair types [Term] id: MT:0000403 name: curvature of zigzag hairs namespace: Trait.ontology def: "greater bending arch of the zigzag hairs" [J:47620] is_a: MT:0000396 ! curvature of hairs is_a: MT:0000402 ! zigzag hair morphology [Term] id: MT:0000405 name: auchene hair morphology namespace: Trait.ontology def: "anomalies of truncal hairs that contain two or more air cells in the medulla" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] is_a: MT:0000395 ! hair types [Term] id: MT:0000406 name: curvature of auchene hairs namespace: Trait.ontology def: "greater bending arch of the auchene hairs" [J:47620] is_a: MT:0000396 ! curvature of hairs is_a: MT:0000405 ! auchene hair morphology [Term] id: MT:0000407 name: duvet hair morphology namespace: Trait.ontology def: "anomalies of the fine under hair of the coat" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] is_a: MT:0000395 ! hair types [Term] id: MT:0000410 name: waved hair namespace: Trait.ontology def: "hair or fur having undulations or a sinusoidal shape" [J:47620] synonym: "curly hair" EXACT [] synonym: "waved fur" EXACT [] synonym: "wavy hair" EXACT [] is_a: MT:0001510 ! coat appearance [Term] id: MT:0000411 name: shiny fur namespace: Trait.ontology def: "fur with a glossy or glistening appearance" [J:45065] is_a: MT:0001510 ! coat appearance [Term] id: MT:0000413 name: phalanx number namespace: Trait.ontology def: "increased number of phalanges in any of the digits" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, J:13069] is_a: MT:0005306 ! phalanx morphology [Term] id: MT:0000414 name: hair retention namespace: Trait.ontology def: "length of time that hair is maintained without noticable loss" [J:30772, J:33796, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "onset of hair loss" EXACT [] is_a: MT:0002073 ! hair growth [Term] id: MT:0000416 name: hair density namespace: Trait.ontology def: "number of body hair within a defined area" [J:46854] synonym: "coat density" RELATED [] is_a: MT:0001510 ! coat appearance is_a: MT:0002073 ! hair growth [Term] id: MT:0000417 name: hair length namespace: Trait.ontology def: "reduced average length of the hairs" [J:64948] is_a: MT:0002073 ! hair growth [Term] id: MT:0000418 name: patchy hair namespace: Trait.ontology def: "uneven spots of hair growth on the body" [J:26975] is_a: MT:0001510 ! coat appearance [Term] id: MT:0000419 name: rough hair namespace: Trait.ontology def: "greasy, matted appearance of the fur" [J:31155] is_a: MT:0002074 ! hair texture [Term] id: MT:0000420 name: ruffled hair namespace: Trait.ontology def: "fuzzy, irregular appearance of the hair" [J:50844] is_a: MT:0001510 ! coat appearance [Term] id: MT:0000421 name: mottled coat namespace: Trait.ontology def: "coat has spots, streaks, and/or blotches of a different color" [J:17194] synonym: "mottled fur" EXACT [] is_a: MT:0005366 ! variegated coat color [Term] id: MT:0000422 name: onset of hair appearance namespace: Trait.ontology def: "time of the first appearance of the hair" [J:17792] synonym: "delayed hair growth" EXACT [] is_a: MT:0002073 ! hair growth [Term] id: MT:0000423 name: onset of hair regrowth namespace: Trait.ontology def: "timing of initiation and synchrony of the hair growth cycle (anagen) after catagen phase " [J:61509] is_a: MT:0002073 ! hair growth [Term] id: MT:0000424 name: hair growth rate namespace: Trait.ontology def: "slow growth of the hair, appears at normal time" [J:5476] is_a: MT:0002073 ! hair growth [Term] id: MT:0000425 name: cilia retention namespace: Trait.ontology def: "ilength of time that eyelashes are maintained without noticable loss" [J:45400] synonym: "loss of eyelashes" EXACT [] is_a: MT:0002073 ! hair growth [Term] id: MT:0000426 name: ectopic hair growth namespace: Trait.ontology def: "positional abnormality of hair " [J:24350] synonym: "heterotopic hair growth" EXACT [] is_a: MT:0002073 ! hair growth [Term] id: MT:0000427 name: hair cycle namespace: Trait.ontology def: "aberrant growth or asynchronous timing of the hair growth " [J:65302] is_a: MT:0002073 ! hair growth [Term] id: MT:0000428 name: craniofacial morphology namespace: Trait.ontology def: "anomalous structure or development of the face and/or cranium" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] subset: slim_pig synonym: "craniofacial abnormalities" EXACT [] synonym: "craniofacial defects" EXACT [] is_a: MT:0005382 ! craniofacial trait [Term] id: MT:0000430 name: maxillary shelf morphology namespace: Trait.ontology alt_id: MT:0000112 def: "missing outgrowth of the maxilla; normally fuses with palatine shelf to form secondary palate" [J:17489, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "absent maxillary palatial process" EXACT [] synonym: "absent palatine process" EXACT [] is_a: MT:0000455 ! maxilla morphology [Term] id: MT:0000431 name: palatine shelf morphology namespace: Trait.ontology alt_id: MT:0000113 def: "missing outgrowth of the palatine bone; normally fuses with maxillary shelf to form secondary palate " [J:17489, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "absent horizontal plate" RELATED [] synonym: "absent palatine palatal process" EXACT [] is_a: MT:0005249 ! palatine bone morphology [Term] id: MT:0000432 name: head morphology namespace: Trait.ontology def: "anomalous structure or development of the portion of the body containing the brain and organs of sight, hearing, taste, and smell" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] subset: slim_pig synonym: "abnormal head" EXACT [] synonym: "head abnormalities" EXACT [] is_a: MT:0000428 ! craniofacial morphology [Term] id: MT:0000436 name: head movements namespace: Trait.ontology alt_id: MT:0001390 def: "anomalous motion of the portion of the body containing the brain and organs of sight, hearing, taste, and smell " [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal head movement" EXACT [] is_a: MT:0001388 ! stationary movement [Term] id: MT:0000437 name: taut facial appearance namespace: Trait.ontology def: "skin of face has appearance of being drawn or pulled tightly" [J:61768] is_a: MT:0003743 ! facial morphology [Term] id: MT:0000438 name: skull morphology namespace: Trait.ontology def: "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "abnormal cranium" EXACT [] synonym: "abnormal skull" EXACT [] synonym: "cranial abnormalities" EXACT [] synonym: "skull abnormalities" EXACT [] is_a: MT:0002116 ! craniofacial bone morphology [Term] id: MT:0000443 name: snout morphology namespace: Trait.ontology def: "anomalous structure or development of the anterior facial part of the muzzle" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "abnormal snout" EXACT [] synonym: "snout abnormalities" EXACT [] is_a: MT:0003743 ! facial morphology [Term] id: MT:0000444 name: snout shape namespace: Trait.ontology def: "morphological anomalies of the anterior facial part of the muzzle" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "snout shape abnormalities" EXACT [] is_a: MT:0000443 ! snout morphology [Term] id: MT:0000446 name: snout length namespace: Trait.ontology def: "the anterior facial part of the muzzle having a length greater than seen in controls" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] is_a: MT:0000444 ! snout shape [Term] id: MT:0000447 name: flattened snout namespace: Trait.ontology def: "a snout flattened laterally along the whole length without the appearance of distinctive curvature" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0000444 ! snout shape [Term] id: MT:0000448 name: pointed snout namespace: Trait.ontology def: "nose tapers to a small tip, sharper angle than wild type " [J:18378] is_a: MT:0000444 ! snout shape [Term] id: MT:0000449 name: nasal bridge width namespace: Trait.ontology def: "distance across the upper part of the ridge of the nose" [J:53370] is_a: MT:0000444 ! snout shape [Term] id: MT:0000451 name: scaly muzzle namespace: Trait.ontology def: "muzzle covered with shedding scales or flakes" [J:56641] is_a: MT:0000443 ! snout morphology [Term] id: MT:0000452 name: mouth morphology namespace: Trait.ontology def: "anomalous structure or development of the oral cavity" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "abnormal mouth" EXACT [] synonym: "mouth abnormalities" EXACT [] is_a: MT:0003744 ! orofacial morphology [Term] id: MT:0000454 name: jaw morphology namespace: Trait.ontology def: "malformation of the bony framework of the mouth where the teeth are held" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal jaw" EXACT [] synonym: "jaw abnormalities" EXACT [] is_a: MT:0000438 ! skull morphology [Term] id: MT:0000455 name: maxilla morphology namespace: Trait.ontology alt_id: MT:0000089 def: "malformation of the upper bony framework of the mouth where the superior teeth are held" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal maxilla" EXACT [] synonym: "Abnormal Upper Jaw" EXACT [] is_a: MT:0000454 ! jaw morphology is_a: MT:0005274 ! viscerocranium morphology is_a: MT:0005552 ! orbital bone morphology [Term] id: MT:0000458 name: mandible morphology namespace: Trait.ontology alt_id: MT:0000086 def: "malformation of the lower bony framework of the mouth where the inferior teeth are held" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal lower jaw" EXACT [] synonym: "abnormal mandible" EXACT [] is_a: MT:0000454 ! jaw morphology is_a: MT:0005274 ! viscerocranium morphology [Term] id: MT:0000459 name: presacral vertebrae namespace: Trait.ontology def: "malformation or absence of the vertebrae anterior to the sacrum" [J:13069] is_a: MT:0000137 ! vertebrae morphology [Term] id: MT:0000461 name: number of presacral vertebrae namespace: Trait.ontology def: "reduced number of the vertebrae anterior to the sacrum" [J:13069] synonym: "reduced number of presacral vertebrae" EXACT [] is_a: MT:0000459 ! presacral vertebrae relationship: part_of MT:0000138 ! vertebrae number [Term] id: MT:0000462 name: digestive system morphology namespace: Trait.ontology alt_id: MT:0000463 alt_id: MT:0002141 def: "anomalous structure of the system dedicated to the mechanical, chemical, and enzymatic processing of food" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] subset: slim_chkn subset: slim_pig synonym: "digestive system abnormalities" EXACT [] synonym: "digestive system defects" EXACT [] synonym: "digestive system: dysmorphology" EXACT [] xref: MGI:2173601 is_a: MT:0005381 ! digestive/alimentary trait [Term] id: MT:0000465 name: gastrointestinal hemorrhage namespace: Trait.ontology def: "bleeding in the stomach and/or the intestines" [J:60896, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8, tc:Teresa Chu_Mouse Genome Informatics Curator] synonym: "gastroenteric bleeding" EXACT [] synonym: "gastroenteric hemorrhage" EXACT [] synonym: "gastrointestinal bleeding" EXACT [] is_a: MT:0001663 ! digestive system physiology [Term] id: MT:0000466 name: esophageal epithelium cell number namespace: Trait.ontology def: "increased cell number in the epithelial layer of the esophagus" [J:47225] synonym: "hyperplasia of the esophageal epithelium" EXACT [] is_a: MT:0000468 ! esophageal epithelium morphology [Term] id: MT:0000467 name: esophagus morphology namespace: Trait.ontology def: "malformation of the part of the digestive canal through which food passes from the pharynx to the stomach" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8, tc:Teresa Chu_Mouse Genome Informatics Curator] synonym: "abnormal esophagus" EXACT [] synonym: "esophagus abnormalities" EXACT [] is_a: MT:0000462 ! digestive system morphology [Term] id: MT:0000468 name: esophageal epithelium morphology namespace: Trait.ontology def: "malformation of the epithelial layer of the esophagus" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8, tc:Teresa Chu_Mouse Genome Informatics Curator] synonym: "abnormal esophageal epithelium" EXACT [] synonym: "esophageal epithelium abnormalities" EXACT [] is_a: MT:0000467 ! esophagus morphology [Term] id: MT:0000469 name: esophageal squamous epithelium morphology namespace: Trait.ontology def: "malformation of the scaly epithelial layer of the esophagus" [J:54637, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8, tc:Teresa Chu_Mouse Genome Informatics Curator] synonym: "abnormal esophageal squamous epithelium" EXACT [] is_a: MT:0000468 ! esophageal epithelium morphology [Term] id: MT:0000470 name: stomach morphology namespace: Trait.ontology def: "malformation of the sac-like structure of the digestive canal between the esophagus and the small intestine" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal stomach" EXACT [] synonym: "stomach abnormalities" EXACT [] is_a: MT:0000462 ! digestive system morphology [Term] id: MT:0000471 name: stomach epithelium morphology namespace: Trait.ontology def: "malformation of the epithelial layer of the stomach " [tc:Teresa Chu_Mouse Genome Informatics Curator] synonym: "abnormal stomach epithelium" EXACT [] synonym: "stomach epithelium abnormalities" EXACT [] is_a: MT:0000470 ! stomach morphology [Term] id: MT:0000472 name: stomach squamous epithelium morphology namespace: Trait.ontology def: "malformation of the scaly epithelial layer of the stomach" [J:54637, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8, tc:Teresa Chu_Mouse Genome Informatics Curator] synonym: "abnormal stomach squamous epithelium" EXACT [] is_a: MT:0000471 ! stomach epithelium morphology [Term] id: MT:0000473 name: stomach glandular epithelium morphology namespace: Trait.ontology def: "malformation of the gland-containing epithelial layer of the stomach" [J:54637, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8, tc:Teresa Chu_Mouse Genome Informatics Curator] synonym: "abnormal stomach glandular epithelium" EXACT [] is_a: MT:0000471 ! stomach epithelium morphology [Term] id: MT:0000474 name: foregut morphology namespace: Trait.ontology def: "malformed cephalic portion of the primitive digestive tube of the embryo" [J:35802] synonym: "abnormal foregut" EXACT [] synonym: "foregut abnormalities" EXACT [] is_a: MT:0003119 ! digestive system development [Term] id: MT:0000476 name: cochlear nerve fiber response namespace: Trait.ontology def: "the electrophysiological recordings from a single or several auditory nerve fiber(s" [smb:Susan M. Bello_Mouse Genome Informatics Curator] synonym: "auditory nerve fiber response" RELATED [] is_a: MT:0000365 ! hearing electrophysiology is_a: MT:0000483 ! sensorineural hearing function is_a: MT:0003477 ! nerve fiber response [Term] id: MT:0000477 name: intestine morphology namespace: Trait.ontology alt_id: MT:0000475 def: "malformation of the digestive tube passing from the stomach to the anus" [J:48968] subset: slim_pig synonym: "abnormal bowel wall" EXACT [] synonym: "abnormal intestine" EXACT [] synonym: "bowel wall abnormalities" EXACT [] synonym: "intestinal abnormalities" EXACT [] is_a: MT:0000462 ! digestive system morphology [Term] id: MT:0000478 name: intestine development namespace: Trait.ontology def: "slowed progression to a structurally mature intestine" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "developmental retardation of the intestine" EXACT [] is_a: MT:0000477 ! intestine morphology is_a: MT:0003119 ! digestive system development [Term] id: MT:0000479 name: intestinal cell morphology namespace: Trait.ontology def: "anomalous structure or development of the cells comprising the intestine" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "abnormal enterocyte" EXACT [] synonym: "intestinal cell abnormalities" EXACT [] is_a: MT:0000477 ! intestine morphology [Term] id: MT:0000481 name: intestinal cell number namespace: Trait.ontology def: "deviation from the normal numbers of enterocytes" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "abnormal enterocyte number" EXACT [] is_a: MT:0000479 ! intestinal cell morphology [Term] id: MT:0000482 name: fibula length namespace: Trait.ontology def: "increased length of the lateral and smaller of bone of the lower leg" [pvb:Pierre Vanden Borre_Mouse Genome Informatics Curator] is_a: MT:0002187 ! fibula morphology [Term] id: MT:0000483 name: sensorineural hearing function namespace: Trait.ontology def: "form of hearing due to processes occuring in the auditory division of cranial nerve VIII or the inner ear" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0001963 ! hearing [Term] id: MT:0000484 name: pulmonary artery morphology namespace: Trait.ontology def: "any measurable or observable characteristic related to the shape, structure, color or pattern of the artery that conveys unaerated blood to the lungs" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] xref: MP:0000484 is_a: MT:0002191 ! artery morphology [Term] id: MT:0000485 name: otoacoustic response namespace: Trait.ontology def: "the acoustic energy produced by the cochlea in the presence or absence of sound stimulation" [smb:Susan M. Bello_Mouse Genome Informatics Curator] synonym: "otoacoustic emissions" RELATED [] is_a: MT:0002104 ! hearing physiology [Term] id: MT:0000486 name: pulmonary trunk integrity namespace: Trait.ontology def: "any measurable characteristic pertaining to the the structural completeness or structural soundness of the region of the pulmonary artery that arises from the right ventricle to the division of the right and left pulmonary artery" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] relationship: part_of MT:0007054 ! pulmonary artery integrity [Term] id: MT:0000488 name: intestinal epithelium morphology namespace: Trait.ontology def: "anomalous structure or development of the cellular avascular layer of the digestive tube passing from the stomach to the anus" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal intestinal epithelium" EXACT [] synonym: "intestinal epithelium abnormalities" EXACT [] is_a: MT:0000477 ! intestine morphology [Term] id: MT:0000489 name: large intestine morphology namespace: Trait.ontology def: "structural or developmental anomalies of the intestinum crassum " [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal large intestine" EXACT [] synonym: "large intestine abnormalities" EXACT [] is_a: MT:0000477 ! intestine morphology [Term] id: MT:0000490 name: crypts of Lieberkuhn morphology namespace: Trait.ontology def: "malformation or defects in the tubular intestinal glands found in the mucosal membranes" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal crypts of Lieberkuhn" EXACT [] synonym: "abnormal intestinal gland morphology" EXACT [] synonym: "abnormal intestinal glands" EXACT [] is_a: MT:0000489 ! large intestine morphology is_a: MT:0000496 ! small intestine morphology is_a: MT:0000511 ! intestinal mucosa morphology is_a: MT:0002163 ! gland morphology [Term] id: MT:0000491 name: crypt abscesses namespace: Trait.ontology def: "an exudate collection associated with inflammation in the crypts of Lieberkuhn of the intestinal mucosa; often associated with ulcerative colitis" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000490 ! crypts of Lieberkuhn morphology [Term] id: MT:0000492 name: rectum morphology namespace: Trait.ontology def: "structural aberration in the terminal portion of the intestinal tube adjacent to the anus" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal rectum" EXACT [] synonym: "rectum abnormalities" EXACT [] is_a: MT:0000489 ! large intestine morphology [Term] id: MT:0000493 name: rectal prolapse namespace: Trait.ontology def: "downward movement and external appearance of the rectum through the anus" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8, tc:Teresa Chu_Mouse Genome Informatics Curator] is_a: MT:0000492 ! rectum morphology [Term] id: MT:0000494 name: cecum morphology namespace: Trait.ontology def: "malformation of the large sac at the ileum and large intestine junction" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal cecum" EXACT [] synonym: "cecum abnormalities" EXACT [] is_a: MT:0000489 ! large intestine morphology [Term] id: MT:0000495 name: colon morphology namespace: Trait.ontology def: "malformation of the portion of the large intestine between the cecum and the rectum" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal colon" EXACT [] synonym: "colon abnormalities" EXACT [] is_a: MT:0000489 ! large intestine morphology [Term] id: MT:0000496 name: small intestine morphology namespace: Trait.ontology def: "structural or developmental anomalies of the intestinum tenue" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] subset: slim_pig synonym: "abnormal small intestine" EXACT [] synonym: "small intestine abnormalities" EXACT [] is_a: MT:0000477 ! intestine morphology [Term] id: MT:0000497 name: small intestine placement namespace: Trait.ontology def: "different location or arrangement of the small intestinal tract" [J:40203] is_a: MT:0000496 ! small intestine morphology is_a: MT:0003283 ! digestive organ placement [Term] id: MT:0000500 name: small intestinal prolapse namespace: Trait.ontology def: "the sinking down of the intestinum tenue " [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000496 ! small intestine morphology [Term] id: MT:0000501 name: digestive secretion namespace: Trait.ontology def: "malfunction of the production and/or release of a physiologically active substance (usually but not exclusively in liquid form) from a cell or a gland of the digestive system" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8, tc:Teresa Chu_Mouse Genome Informatics Curator] synonym: "abnormal secretion" EXACT [] is_a: MT:0001664 ! digestion [Term] id: MT:0000502 name: distortion product otoacoustic emission namespace: Trait.ontology def: "production of sound by the cochlea in response to stimulation with 2 simultaneous tones of different frequencies; this measurement is particularly useful in assessing the functional state of OHCs" [smb:Susan M. Bello_Mouse Genome Informatics Curator] synonym: "DPOAE" RELATED [] is_a: MT:0000485 ! otoacoustic response [Term] id: MT:0000508 name: right-sided isomerism namespace: Trait.ontology def: "the relative symmetry of the organs of the thorax and abdomen as indicated by both atria displaying the morphology of the right atrium" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, J:58530] is_a: MT:0002089 ! postnatal growth/weight/body size [Term] id: MT:0000509 name: digestive mucosecretion namespace: Trait.ontology def: "missing the production and/or release of a physiologically active substance (usually but not exclusively in liquid form) from the mucous membrane of the digestive system" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8, tc:Teresa Chu_Mouse Genome Informatics Curator] synonym: "absence of digestive mucosecretion" EXACT [] synonym: "absence of mucosecretion" EXACT [] synonym: "loss of mucosecretion" EXACT [] is_a: MT:0000501 ! digestive secretion [Term] id: MT:0000510 name: remittent intestinal hemorrhage namespace: Trait.ontology def: "loss of blood from the intestines that is characterized by temporary periods of abatement" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "remittent intestinal bleeding" EXACT [] is_a: MT:0000465 ! gastrointestinal hemorrhage [Term] id: MT:0000511 name: intestinal mucosa morphology namespace: Trait.ontology def: "structural or developmental anomalies of the mucous lining of the intestine; this consists of epithelium, lamina propria, and a layer of smooth muscle cells" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal intestinal mucosa" EXACT [] synonym: "abnormal mucosa of the intestine" EXACT [] synonym: "intestinal mucosa abnormalities" EXACT [] is_a: MT:0000488 ! intestinal epithelium morphology [Term] id: MT:0000512 name: intestinal ulcer namespace: Trait.ontology def: "lesions in the mucous lining of the intestine" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "intestinal ulcers" EXACT [] synonym: "mucosal ulceration of the intestine" EXACT [] is_a: MT:0000511 ! intestinal mucosa morphology is_a: MT:0003300 ! gastrointestinal ulcer [Term] id: MT:0000513 name: susceptibility to hearing loss namespace: Trait.ontology def: "the sensitivity to loss of hearing related to age or environmental factors" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0001963 ! hearing [Term] id: MT:0000516 name: urinary system morphology namespace: Trait.ontology alt_id: MT:0000517 def: "structural or developmental anomaly of any of the organs involved in the production or excretion of urine " [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "abnormal urinary organs" EXACT [] synonym: "excretory system defects" EXACT [] synonym: "urinary organ abnormalities" EXACT [] is_a: MT:0005367 ! renal/urinary system trait [Term] id: MT:0000519 name: hydronephrosis namespace: Trait.ontology def: "dilation of the pelvis and calices of one or both kidneys" [J:56641] synonym: "renal pelvic dilation" EXACT [] is_a: MT:0004194 ! kidney pelvis morphology [Term] id: MT:0000521 name: kidney cortex namespace: Trait.ontology def: "anomalous structure or development of the outer area of the kidney, which contains the glomerular capillaries and the capsula glomeruli that enclose it " [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "kidney cortex abnormalities" EXACT [] is_a: MT:0002135 ! kidney morphology [Term] id: MT:0000522 name: cysts in kidney cortex namespace: Trait.ontology def: "abnormal membranous sacs appearing in the renal lobules, tubules and glomeruli" [J:50844] is_a: MT:0000521 ! kidney cortex is_a: MT:0003675 ! kidney cysts [Term] id: MT:0000523 name: cortical glomerulopathies namespace: Trait.ontology def: "any disease of the capillary plexus in the kidney cortex" [J:63229, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0005325 ! glomerulus morphology [Term] id: MT:0000524 name: renal tubule number namespace: Trait.ontology def: "fewer loops of Henle and collecting ducts" [J:40203] synonym: "reduced number of renal tubules" EXACT [] is_a: MT:0002703 ! renal tubule morphology [Term] id: MT:0000525 name: renal tubular acidosis namespace: Trait.ontology def: "a clinical syndrome characterized by the inability to acidify urine" [J:19268, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002136 ! kidney physiology [Term] id: MT:0000526 name: inner medullary pyramid size namespace: Trait.ontology def: "reduced size of pyramidal masses; contain part of the secreting tubules and collecting tubules" [J:40203, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0004192 ! kidney pyramid morphology [Term] id: MT:0000527 name: kidney development namespace: Trait.ontology def: "anomalous differentiation of the paired organs responsible for urine secretion" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "abnormal renal development" EXACT [] synonym: "kidney development abnormalities" EXACT [] is_a: MT:0002135 ! kidney morphology is_a: MT:0003942 ! urinary system development [Term] id: MT:0000528 name: onset of kidney development namespace: Trait.ontology alt_id: MT:0000529 def: "late onset of the induction and/or differentiation of the kidney" [J:18048] synonym: "delayed renal development" EXACT [] synonym: "developmental retardation of kidney" EXACT [] is_a: MT:0000527 ! kidney development [Term] id: MT:0000530 name: kidney blood vessel morphology namespace: Trait.ontology def: "any measurable or observable characteristic related to the shape, structure, color or pattern of the the blood vessel network of the organ of excretion" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] synonym: "kidney vascular morphology" RELATED [] synonym: "kidney vasculature" EXACT [] synonym: "renal vasculature" RELATED [] xref: MP:0000530 is_a: MT:0001614 ! blood vessel morphology is_a: MT:0002135 ! kidney morphology [Term] id: MT:0000531 name: right pulmonary isomerism namespace: Trait.ontology def: "bilaterally symmetric right lung pattern (or altered asymmetric patterning of the lung)" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, J:58530] is_a: MT:0000508 ! right-sided isomerism is_a: MT:0001175 ! lung morphology [Term] id: MT:0000532 name: kidney blood vessel patency namespace: Trait.ontology alt_id: MT:0000257 def: "any measurable characteristic pertaining to the openness of the blood vessels of the organ of secretion" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator", RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] synonym: "kidney vascular patency" EXACT [] synonym: "patency of the renal vasculature" RELATED [] is_a: MT:0005412 ! blood vessel patency relationship: part_of MT:0007055 ! kidney blood vessel integrity [Term] id: MT:0000533 name: kidney hemorrhage namespace: Trait.ontology def: "bleeding in the organ of excretion" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8, tc:Teresa Chu_Mouse Genome Informatics Curator] synonym: "kidney bleeding" EXACT [] is_a: MT:0002136 ! kidney physiology [Term] id: MT:0000534 name: ureter morphology namespace: Trait.ontology def: "anomalous structure of the tube that conducts the urine from the renal pelvis to the bladder" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "ureter abnormalities" EXACT [] is_a: MT:0000516 ! urinary system morphology [Term] id: MT:0000535 name: ureter luminal epithelial cell number namespace: Trait.ontology def: "increased cell number in the luminal epithelium of the tube that conducts the urine from the renal pelvis to the bladder" [J:56641] synonym: "hyperplasia of the luminal epithelium of ureter" EXACT [] is_a: MT:0000534 ! ureter morphology [Term] id: MT:0000536 name: hydroureter namespace: Trait.ontology def: "distention of the ureter with urine, due to blockage from any cause" [cml:Cathleen M. Lutz_Mouse Genome Informatics Curator, J:13044, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000534 ! ureter morphology [Term] id: MT:0000537 name: urethra morphology namespace: Trait.ontology def: "anomalous structure of the canal leading from the bladder, discharging the urine externally" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "urethra abnormalities" EXACT [] is_a: MT:0000516 ! urinary system morphology [Term] id: MT:0000538 name: urinary bladder morphology namespace: Trait.ontology def: "malformation of the inflatable musculomembranous bag for holding urine" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal urinary bladder" EXACT [] is_a: MT:0000516 ! urinary system morphology [Term] id: MT:0000539 name: urinary bladder size namespace: Trait.ontology def: "stretched musculomembranous bag for holding urine" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "urinary bladder distension" EXACT [] is_a: MT:0000538 ! urinary bladder morphology [Term] id: MT:0000540 name: urinary bladder epithelium morphology namespace: Trait.ontology def: "malformation of the epithelial layer of the urinary bladder" [tc:Teresa Chu_Mouse Genome Informatics Curator] synonym: "urinary bladder epithelium abnormalities" EXACT [] is_a: MT:0000538 ! urinary bladder morphology [Term] id: MT:0000541 name: urinary bladder transitional epithelium morphology namespace: Trait.ontology def: "malformation of the transitional epithelial layer of the urinary bladder" [tc:Teresa Chu_Mouse Genome Informatics Curator] synonym: "urinary bladder transitional epithelium abnormalities" EXACT [] is_a: MT:0000540 ! urinary bladder epithelium morphology [Term] id: MT:0000542 name: left-sided isomerism namespace: Trait.ontology def: "the relative symmetry of the organs of the thorax and abdomen as indicated by both atria displaying the morphology of the left atrium" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0002089 ! postnatal growth/weight/body size [Term] id: MT:0000544 name: urinary bladder transitional epithelium thickness namespace: Trait.ontology def: "decrease in the thickness of the transitional epithelial layer of the urinary bladder" [J:54637, tc:Teresa Chu_Mouse Genome Informatics Curator] is_a: MT:0000541 ! urinary bladder transitional epithelium morphology [Term] id: MT:0000545 name: limbs/digits/tail morphology namespace: Trait.ontology def: "morphological or developmental anomaly of the digits, autopod, limbs, or tail" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] subset: slim_cattle subset: slim_chkn subset: slim_pig synonym: "abnormal extremities" EXACT [] synonym: "abnormal extremity morphology" EXACT [] synonym: "extremities abnormalities" EXACT [] synonym: "extremities defects" EXACT [] is_a: MT:0005371 ! limbs/digits/tail trait [Term] id: MT:0000548 name: limb length namespace: Trait.ontology def: "average length of the extremities" [tc:Teresa Chu_Mouse Genome Informatics Curator] subset: slim_pig synonym: "leg length" RELATED [] is_a: MT:0002109 ! limb morphology [Term] id: MT:0000550 name: forelimb morphology namespace: Trait.ontology def: "Any measurable or observable characteristic related to the shape, structure, color or pattern of the anterior extremeties" [tc:Teresa Chu_Mouse Genome Informatics Curator] subset: slim_chkn subset: slim_pig synonym: "forelimb abnormalities" EXACT [] is_a: MT:0002109 ! limb morphology [Term] id: MT:0000552 name: radius morphology namespace: Trait.ontology def: "malformation of the short bone of the lateral forearm" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal radius" EXACT [] is_a: MT:0003723 ! long bone morphology [Term] id: MT:0000554 name: carpal bone morphology namespace: Trait.ontology def: "malformation of the nine nodular bones of the joint between the forelimb bones and the front paws consisting of the scapholunar, triangular, greater multiangular, lesser multiangular, capitate, hamate, centrale and the sesamoids" [Anatomy of the Rat:Greene EC_Hafner Publishing Co_1935, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] comment: Note that the bony structure of the human carpals are different. synonym: "abnormal carpal bone" EXACT [] synonym: "abnormal carpus" EXACT [] synonym: "abnormal wrist" EXACT [] is_a: MT:0002115 ! skeleton extremities morphology [Term] id: MT:0000556 name: hindlimb morphology namespace: Trait.ontology def: "Any measurable or observable characteristic related to the shape, structure, color or pattern of the posterior extremeties" [tc:Teresa Chu_Mouse Genome Informatics Curator] subset: slim_chkn subset: slim_pig synonym: "hindlimb abnormalities" EXACT [] is_a: MT:0002109 ! limb morphology [Term] id: MT:0000558 name: tibia morphology namespace: Trait.ontology def: "structural anomaly of the medial and larger of the two bones of the lower leg" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] subset: slim_chkn synonym: "abnormal tibia" EXACT [] is_a: MT:0003723 ! long bone morphology [Term] id: MT:0000559 name: femur morphology namespace: Trait.ontology def: "structural anomaly of the long bone of the thigh" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] subset: slim_pig synonym: "abnormal femur" EXACT [] is_a: MT:0003723 ! long bone morphology [Term] id: MT:0000561 name: adactyly namespace: Trait.ontology def: "missing all digits; usually referred to as a congenital condition" [J:54637, tc:Teresa Chu_Mouse Genome Informatics Curator] synonym: "absence of digits" EXACT [] is_a: MT:0002110 ! digit morphology [Term] id: MT:0000562 name: polydactyly namespace: Trait.ontology def: "greater than 5 digits on one or more autopods" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002110 ! digit morphology [Term] id: MT:0000564 name: syndactyly namespace: Trait.ontology def: "any degree of webbing or fusion of the digits, may involve only soft tissues or also can include bone" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002110 ! digit morphology [Term] id: MT:0000565 name: oligodactyly namespace: Trait.ontology alt_id: MT:0000563 def: "congenital condition in which some digits or parts of digits are missing" [J:53370, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "hypodactyly" EXACT [] is_a: MT:0002110 ! digit morphology [Term] id: MT:0000566 name: synostosis namespace: Trait.ontology def: "osseous union of two bones that are not normally connected" [J:13049] is_a: MT:0002110 ! digit morphology [Term] id: MT:0000567 name: truncation of digits namespace: Trait.ontology def: "absence of the most proximal regions of toes" [J:19212] is_a: MT:0002110 ! digit morphology [Term] id: MT:0000568 name: ectopic digits namespace: Trait.ontology def: "positional abnormality of a digit" [J:50311] synonym: "heterotopic digits" EXACT [] is_a: MT:0002110 ! digit morphology [Term] id: MT:0000569 name: digit pigmentation namespace: Trait.ontology alt_id: MT:0000570 def: "anomalous coloration of the fingers or toes" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "altered digit pigmentation" EXACT [] synonym: "white hind toes" EXACT [] is_a: MT:0001186 ! pigmentation trait is_a: MT:0002110 ! digit morphology [Term] id: MT:0000571 name: interdigital webbing namespace: Trait.ontology def: "fold of skin, or web, between the toes that is not normally present" [J:49840, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002110 ! digit morphology [Term] id: MT:0000572 name: autopod morphology namespace: Trait.ontology def: "malformation of the distal elements of the developing limb of vertebrates that will give rise to the pedal or prehensile appendages (e.g. hand, foot, paw, phalanges and/or digits)" [PMID:12560810] is_a: MT:0006279 ! limb development [Term] id: MT:0000573 name: hind paw size namespace: Trait.ontology def: "larger than average size of the rear feet" [J:51296] is_a: MT:0004271 ! paw/hand/foot/hoof morphology [Term] id: MT:0000574 name: foot pad morphology namespace: Trait.ontology def: "anomalous structure of the body of fat on the foot" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "abnormal foot pads" EXACT [] is_a: MT:0004271 ! paw/hand/foot/hoof morphology [Term] id: MT:0000575 name: foot pad pigmentation namespace: Trait.ontology def: "darker color of the foot pads due to excess pigment" [cml:Cathleen M. Lutz_Mouse Genome Informatics Curator] is_a: MT:0000574 ! foot pad morphology is_a: MT:0002095 ! skin pigmentation [Term] id: MT:0000576 name: clubfoot namespace: Trait.ontology def: "congenital deformation of the feet; foot is plantarflexed, inverted and adducted" [J:61295, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "club foot" EXACT [] synonym: "clubbed feet" EXACT [] is_a: MT:0004271 ! paw/hand/foot/hoof morphology [Term] id: MT:0000578 name: ulcerated paws namespace: Trait.ontology def: "inflammatory, often suppurating lesions on the paws; often become necrotic" [J:17194] is_a: MT:0004271 ! paw/hand/foot/hoof morphology [Term] id: MT:0000579 name: nail morphology namespace: Trait.ontology def: "structural or developmental anomaly of any of the thin, horny, translucent plates covering the dorsal surface of the distal end of each terminal phalanx of the digits" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal nail" EXACT [] synonym: "nail abnormalities" EXACT [] is_a: MT:0005393 ! skin/coat/nails/feathers trait [Term] id: MT:0000580 name: nail shape namespace: Trait.ontology def: "atypical shape or size of the nails" [J:45400] is_a: MT:0000579 ! nail morphology [Term] id: MT:0000581 name: ventral nails/ hair namespace: Trait.ontology def: "appearance of nails and hair on the ventral side of the paw" [J:50311] is_a: MT:0000579 ! nail morphology [Term] id: MT:0000582 name: toenail hyperkeratosis namespace: Trait.ontology def: "keratin extensions from the toenails" [J:62478] is_a: MT:0000579 ! nail morphology [Term] id: MT:0000583 name: toenail length namespace: Trait.ontology def: "increased length of the toenails" [J:65045] is_a: MT:0000579 ! nail morphology [Term] id: MT:0000588 name: tail diameter namespace: Trait.ontology def: "length of a straight line segment passing through a specified cross-section of the tail " [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] is_a: MT:0003456 ! tail size [Term] id: MT:0000593 name: susceptibility to noise-induced hearing loss namespace: Trait.ontology def: "sensitivity to reduction in hearing following exposure to acute noise that is injurious to the cochlea" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0000513 ! susceptibility to hearing loss [Term] id: MT:0000596 name: liver development namespace: Trait.ontology def: "anomalous differentiation of the liver" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] is_a: MT:0000598 ! liver morphology is_a: MT:0003943 ! liver/biliary system development [Term] id: MT:0000597 name: onset of hepatic development namespace: Trait.ontology def: "late onset of the induction and/or differentiation of the liver" [J:18048] is_a: MT:0000596 ! liver development [Term] id: MT:0000598 name: liver morphology namespace: Trait.ontology alt_id: MT:0000595 def: "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, J:23170, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] subset: slim_chkn subset: slim_pig synonym: "abnormal liver" EXACT [] synonym: "Liver" EXACT [] is_a: MT:0002138 ! liver/biliary system morphology [Term] id: MT:0000599 name: liver size namespace: Trait.ontology def: "larger than average size of the liver" [J:65146] synonym: "hepatomegaly" EXACT [] is_a: MT:0000598 ! liver morphology [Term] id: MT:0000602 name: sinusoidal space size namespace: Trait.ontology def: "larger than normal sized cavities in the liver " [J:23170] is_a: MT:0000598 ! liver morphology [Term] id: MT:0000603 name: liver color namespace: Trait.ontology def: "liver lacking normal coloration, often refers to bloodless condition" [J:18048] is_a: MT:0000598 ! liver morphology [Term] id: MT:0000604 name: amyloidosis namespace: Trait.ontology alt_id: MT:0000695 def: "an accumulation of extracellular amyloid in tissues of the body" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "amyloidosis" EXACT [] is_a: MT:0005395 ! other trait [Term] id: MT:0000606 name: hepatocyte number namespace: Trait.ontology def: "fewer than normal number of parenchymal liver cells" [J:23170] synonym: "reduced hepatocyte cell number" EXACT [] is_a: MT:0000607 ! hepatocyte morphology [Term] id: MT:0000607 name: hepatocyte morphology namespace: Trait.ontology alt_id: MT:0000605 alt_id: MT:0002821 def: "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal hepatocyte" EXACT [] synonym: "abnormal hepatocytes" EXACT [] synonym: "abnormal liver cells" EXACT [] is_a: MT:0000598 ! liver morphology [Term] id: MT:0000608 name: dissociated hepatocytes namespace: Trait.ontology def: "disorganization of cohesive hepatocyte structure" [J:23170] synonym: "dissociation of liver parenchymal cells" EXACT [] is_a: MT:0000607 ! hepatocyte morphology [Term] id: MT:0000609 name: liver physiology namespace: Trait.ontology def: "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal liver function" EXACT [] is_a: MT:0002139 ! liver/biliary system physiology [Term] id: MT:0000610 name: cholestasis namespace: Trait.ontology def: "impairment of bile flow due to obstruction in small bile ducts (intrahepatic cholestasis) or obstruction in large bile ducts (extrahepatic cholestasis)" [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "bile duct obstruction" EXACT [] synonym: "bile stasis" EXACT [] synonym: "biliary stasis" EXACT [] is_a: MT:0000609 ! liver physiology [Term] id: MT:0000611 name: jaundice namespace: Trait.ontology def: "clinical manifestation of hyperbilirubinemia, with deposition of bile pigments in the skin, resulting in yellowish staining of the skin and mucous membranes" [MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0000609 ! liver physiology [Term] id: MT:0000612 name: susceptibility to age-related hearing loss namespace: Trait.ontology def: "sensitivity to reduction in hearing associated with increased age" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0000513 ! susceptibility to hearing loss [Term] id: MT:0000613 name: salivary gland morphology namespace: Trait.ontology def: "malformed saliva-secreting glands of the oral cavity" [J:63764, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal salivary glands" EXACT [] is_a: MT:0000462 ! digestive system morphology is_a: MT:0002163 ! gland morphology [Term] id: MT:0000615 name: palatine gland morphology namespace: Trait.ontology def: "malformed salivary gland of the hard palate" [J:64981, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal palatine gland" EXACT [] is_a: MT:0003791 ! minor salivary gland morphology [Term] id: MT:0000616 name: palatine gland ductal branching morphology namespace: Trait.ontology def: "fewer branches and distal tips of the vesicles of the palatine gland" [J:64981] is_a: MT:0000615 ! palatine gland morphology is_a: MT:0000620 ! salivary duct morphology [Term] id: MT:0000617 name: number of salivary gland mucosal cells namespace: Trait.ontology def: "greater than normal number of cells that form mucus in the salivary glands" [J:64981] is_a: MT:0000615 ! palatine gland morphology [Term] id: MT:0000619 name: salivary gland epithelial cell morphology namespace: Trait.ontology def: "increased cell number in the epithelium of the salivary gland" [J:63764, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000613 ! salivary gland morphology [Term] id: MT:0000620 name: salivary duct morphology namespace: Trait.ontology def: "reduced diameter of the tubular canals that carry saliva" [J:63764, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000613 ! salivary gland morphology [Term] id: MT:0000621 name: salivary adenocarcinoma namespace: Trait.ontology alt_id: MT:0002040 def: "malignant neoplasm of the secreting cells of the salivary gland" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "acinar carcinoma" EXACT [] synonym: "acinic cell adenocarcinoma" EXACT [] synonym: "acinic cell carcinoma" EXACT [] synonym: "Salivary Adenocarcinomas" EXACT [] is_a: MT:0002038 ! carcinoma [Term] id: MT:0000623 name: salivation namespace: Trait.ontology def: "decrease flow, secretion, or amount of saliva" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "sialoschesis" EXACT [] is_a: MT:0005310 ! salivary gland physiology [Term] id: MT:0000624 name: xerostomia namespace: Trait.ontology def: "dryness of the mouth resulting from reduced salivary secretion" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000623 ! salivation is_a: MT:0003745 ! mucosal lining of the mouth [Term] id: MT:0000627 name: mammary gland morphology namespace: Trait.ontology def: "malformation of the milk-secreting gland that lies within the breast; usually rudimentary in males" [J:70183] subset: slim_cattle subset: slim_pig synonym: "abnormal mammary glands" EXACT [] is_a: MT:0001119 ! female reproductive anatomy is_a: MT:0002163 ! gland morphology [Term] id: MT:0000628 name: mammary gland development namespace: Trait.ontology alt_id: MT:0003428 def: "aberration in the differentiation of the mammary gland during early embryogenesis or during sexual maturity" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal mammary development" EXACT [] is_a: MT:0000627 ! mammary gland morphology is_a: MT:0003936 ! reproductive system development [Term] id: MT:0000631 name: neuroendocrine gland morphology namespace: Trait.ontology def: "anomalous structure of any of the organized aggregations of cells that function as secretory or excretory organs and that release hormones in response to neural stimuli" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal neuroendocrine glands" EXACT [] is_a: MT:0002163 ! gland morphology [Term] id: MT:0000632 name: pineal gland morphology namespace: Trait.ontology def: "anomalous structure of the small, flattened body located in the depression between the superior colliculi and which produces melatonin" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal glandula pinealis" EXACT [] synonym: "abnormal pineal body" EXACT [] synonym: "abnormal pineal gland" EXACT [] is_a: MT:0000631 ! neuroendocrine gland morphology is_a: MT:0000840 ! epithalamus morphology [Term] id: MT:0000633 name: pituitary gland morphology namespace: Trait.ontology def: "anomalous structure of the compound gland suspended from the base of the hypothalamus, which secretes somatotropins, prolactin, TSH (thyroid-stimulating hormone), gonadotropins, adrenal corticotropin" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal hypophysis" EXACT [] synonym: "abnormal pituitary gland" EXACT [] is_a: MT:0000631 ! neuroendocrine gland morphology is_a: MT:0000830 ! diencephalon morphology [Term] id: MT:0000637 name: susceptibility to ototoxicity-induced hearing loss namespace: Trait.ontology def: "sensitivity to reduction in hearing following exposure to an ototoxic compound" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0000513 ! susceptibility to hearing loss [Term] id: MT:0000638 name: cochlear hair cell development namespace: Trait.ontology def: "initial production, differentiation, migration or maturation of the sensory epithelial cells of the cochlea" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0002622 ! cochlear hair cell morphology is_a: MT:0003938 ! ear development [Term] id: MT:0000639 name: adrenal gland morphology namespace: Trait.ontology def: "malformed endocrine glands located above the kidney responsible for hormone and epinephrine secretion" [J:61190, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal adrenal gland" EXACT [] is_a: MT:0002163 ! gland morphology [Term] id: MT:0000643 name: adrenal central medulla morphology namespace: Trait.ontology def: "missing marrow like structure; cells here are responsible for secretion of epinephrine" [J:54931, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000639 ! adrenal gland morphology [Term] id: MT:0000646 name: adrenocortical cell morphology namespace: Trait.ontology def: "larger size of cells of the adrenal gland " [J:54931, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000639 ! adrenal gland morphology [Term] id: MT:0000647 name: sebaceous gland morphology namespace: Trait.ontology alt_id: MT:0001226 def: "malformation of the holocrine glands of the dermis that secrete sebum into the hair follicles" [tc:Teresa Chu_Mouse Genome Informatics Curator] is_a: MT:0001216 ! epidermal layer morphology is_a: MT:0002163 ! gland morphology [Term] id: MT:0000652 name: sebaceous gland size namespace: Trait.ontology alt_id: MT:0001229 def: "increased size of the sebum secreting glands of the hair shaft" [J:30249] is_a: MT:0000647 ! sebaceous gland morphology [Term] id: MT:0000653 name: sex gland morphology namespace: Trait.ontology def: "anomalous structure of any of the organized aggregations of cells that function as secretory or excretory organs and are associated with reproduction" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] subset: slim_cattle subset: slim_pig synonym: "abnormal sex glands" EXACT [] is_a: MT:0002163 ! gland morphology [Term] id: MT:0000655 name: sex gland size namespace: Trait.ontology alt_id: MT:0001118 def: "enlargement in the volume of any of the sex glands" [J:62478] synonym: "dilation of sex glands" EXACT [] is_a: MT:0000653 ! sex gland morphology is_a: MT:0002160 ! reproductive system morphology [Term] id: MT:0000659 name: prostate gland size namespace: Trait.ontology alt_id: MT:0001160 def: "increased cell number in the prostate" [J:63764, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "hyperplastic prostate gland" EXACT [] is_a: MT:0001158 ! prostate morphology [Term] id: MT:0000660 name: lateral prostate size namespace: Trait.ontology alt_id: MT:0001161 def: "reduced cell number in the lateral lobe of the prostate" [J:63764, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "hypoplastic lateral prostate" EXACT [] is_a: MT:0000659 ! prostate gland size [Term] id: MT:0000661 name: ventral prostate size namespace: Trait.ontology alt_id: MT:0001162 def: "reduced size of lateral lobe of the prostate" [J:63764, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000659 ! prostate gland size [Term] id: MT:0000662 name: branching of the mammary ductal tree namespace: Trait.ontology def: "anomaly in the development of the channels that secrete milk and direct milk to the nipple" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0000628 ! mammary gland development [Term] id: MT:0000664 name: small coagulating gland namespace: Trait.ontology alt_id: MT:0001164 def: "reduced size of the coagulating gland" [J:64981] is_a: MT:0001163 ! coagulating gland morphology [Term] id: MT:0000665 name: ductal branching of the coagulating gland namespace: Trait.ontology alt_id: MT:0001165 def: "fewer branches and distal tips of the vesicles of the coagulating gland" [J:64981] is_a: MT:0001163 ! coagulating gland morphology [Term] id: MT:0000666 name: number of prostate ducts namespace: Trait.ontology alt_id: MT:0001166 def: "fewer than normal minute canals that pass the prostatic secretions to the urethra" [J:63764, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001158 ! prostate morphology [Term] id: MT:0000672 name: mucin cell number namespace: Trait.ontology alt_id: MT:0001172 def: "fewer than normal number of cells that secrete fluid containing carbohydrate-rich glycoproteins" [J:54465, J:63764, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "reduced number of mucin cells" EXACT [] is_a: MT:0000317 ! cell number [Term] id: MT:0000674 name: sweat gland morphology namespace: Trait.ontology def: "anomalous structure of any of the coil glands of the skin that secrete sweat" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal sweat glands" EXACT [] is_a: MT:0002163 ! gland morphology [Term] id: MT:0000675 name: palmar eccrine gland morphology namespace: Trait.ontology def: "form, structure or size of the sweat glands of the palm" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] synonym: "abnormal palmar eccrine glands" EXACT [] is_a: MT:0000674 ! sweat gland morphology is_a: MT:0004271 ! paw/hand/foot/hoof morphology [Term] id: MT:0000676 name: water content namespace: Trait.ontology def: "more or less than the normal total amount of water retained in the body" [il:Ira Lu_Mouse Genome Informatics Curator] subset: slim_pig is_a: MT:0005451 ! body composition [Term] id: MT:0000678 name: parathyroid gland morphology namespace: Trait.ontology alt_id: MT:0001735 def: "anomalous structure of one of the two small, paired endocrine glands, usually found embedded in the connective tissue capsule on the posterior surface of the thyroid gland; they secrete parathyroid hormone (PTH) that regulates calcium and phosphorous metabolism" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal parathyroid glands" EXACT [] is_a: MT:0002163 ! gland morphology [Term] id: MT:0000681 name: thyroid gland morphology namespace: Trait.ontology alt_id: MT:0001737 def: "anomalous structure of the endocrine gland located in the front and to the sides of the upper part of the trachea and which secretes thyroid hormone and calcitonin" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal thyroid gland" EXACT [] is_a: MT:0002163 ! gland morphology [Term] id: MT:0000683 name: percent water in carcass namespace: Trait.ontology def: "less than the normal total amount of water retained in the body measured post mortem" [il:Ira Lu_Mouse Genome Informatics Curator] is_a: MT:0000676 ! water content [Term] id: MT:0000685 name: immune system morphology namespace: Trait.ontology def: "morphological anomalies in the organs or cells associated with the development and formation of lymphocytes" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] subset: slim_cattle subset: slim_chkn subset: slim_pig synonym: "immune system abnormalities" EXACT [] synonym: "lymphoid system abnormalities" EXACT [] synonym: "lymphopoietic system abnormalities" EXACT [] is_a: MT:0005387 ! immune system trait [Term] id: MT:0000689 name: spleen morphology namespace: Trait.ontology alt_id: MT:0002226 def: "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [J:27463, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] subset: slim_chkn synonym: "abnormal spleen structure" EXACT [] synonym: "spleen abnormalities" EXACT [] is_a: MT:0002396 ! hematopoietic system morphology/development is_a: MT:0002722 ! immune system organ morphology [Term] id: MT:0000696 name: Peyer's patch morphology namespace: Trait.ontology def: "anomalous structure, development, or cellular make-up of the lymphoid tissue located on the mucosa of the small intestine" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal Peyer's patches" EXACT [] is_a: MT:0002339 ! lymph node morphology is_a: MT:0002378 ! gut-associated lymphoid tissue morphology [Term] id: MT:0000700 name: lymph node number namespace: Trait.ontology def: "deviation from the normal number of lymph nodes" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] is_a: MT:0002339 ! lymph node morphology [Term] id: MT:0000701 name: lymph node size namespace: Trait.ontology def: "deviation from the normal lymph node size " [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] is_a: MT:0002221 ! lymph organ size is_a: MT:0002339 ! lymph node morphology [Term] id: MT:0000703 name: thymus morphology namespace: Trait.ontology alt_id: MT:0002366 def: "anomalous structure or development of the primary lymphoid organ; required for immune system development" [J:55400, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal thymus structure" EXACT [] synonym: "thymus abnormalities" EXACT [] is_a: MT:0002396 ! hematopoietic system morphology/development is_a: MT:0002722 ! immune system organ morphology [Term] id: MT:0000704 name: thymus development namespace: Trait.ontology def: "anomaly in the formation and/or differentiation of the thymus" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "abnormal development of the thymus" EXACT [] is_a: MT:0000703 ! thymus morphology [Term] id: MT:0000705 name: athymia namespace: Trait.ontology def: "absence of the primary lymphoid organ" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "Absence of Thymus" EXACT [] synonym: "absent thymus" EXACT [] is_a: MT:0000703 ! thymus morphology [Term] id: MT:0000711 name: thymic cortex cellularity namespace: Trait.ontology def: "reduced cell number in the outer portion of the thymus" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "hypoplasia of thymic cortex" EXACT [] is_a: MT:0002365 ! thymus cellularity is_a: MT:0002371 ! thymus cortex morphology [Term] id: MT:0000712 name: vestibular hair cell development namespace: Trait.ontology def: "initial production, differentiation, migration or maturation of hair cells in the sensory epithelium of the maculae and cristae of the membranous labyrinth of the inner ear" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0002623 ! vestibular hair cell morphology is_a: MT:0003938 ! ear development [Term] id: MT:0000713 name: Reichert's cartilage namespace: Trait.ontology def: "structure or formation of the cartilage found in the mesenchyme of the second pharyngeal arch in the embryo from which develop the stapes, styloid process, lesser horn and upper part of the body of the hyoid bone; its proximal end gives rise to the stylohyoid ligament" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0000163 ! cartilage morphology is_a: MT:0003935 ! craniofacial development is_a: MT:0003938 ! ear development [Term] id: MT:0000715 name: thymocyte number namespace: Trait.ontology alt_id: MT:0000338 alt_id: MT:0000725 alt_id: MT:0001826 def: "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] synonym: "decreased thymocyte number" EXACT [] synonym: "reduced thymocyte number" EXACT [] is_a: MT:0000717 ! lymphocyte number is_a: MT:0002145 ! T lymphocyte development [Term] id: MT:0000716 name: immune system cell morphology namespace: Trait.ontology def: "anomalous structure, development, or number of immune cells" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] comment: new pslim term subset: slim_cattle subset: slim_pig synonym: "abnormal immune cell" EXACT [] synonym: "immune system: cellular abnormalities" EXACT [] is_a: MT:0000685 ! immune system morphology [Term] id: MT:0000717 name: lymphocyte number namespace: Trait.ontology def: "deviation from the normal number of white blood cells" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] subset: slim_pig synonym: "Abnormal Immune Cell Number" EXACT [] is_a: MT:0000221 ! WBC count is_a: MT:0002401 ! lymphopoiesis is_a: MT:0002619 ! lymphocyte morphology/development [Term] id: MT:0000729 name: myogenesis namespace: Trait.ontology def: "anomaly in embryonic formation of muscle cells or fibers" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "myogenesis abnormalities" EXACT [] is_a: MT:0000733 ! muscle development [Term] id: MT:0000731 name: collagen deposition in the muscles namespace: Trait.ontology def: "accumulation of collagen within the muscles" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] is_a: MT:0000733 ! muscle development [Term] id: MT:0000732 name: time of primary myocyte appearance namespace: Trait.ontology def: "development of initial muscle cells at a later time than is normal" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] is_a: MT:0000729 ! myogenesis [Term] id: MT:0000733 name: muscle development namespace: Trait.ontology def: "anomalous differentiation of muscle tissue" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "muscle development abnormalities" EXACT [] is_a: MT:0002108 ! muscle morphology [Term] id: MT:0000736 name: onset of muscle development namespace: Trait.ontology def: "late onset of the induction and/or differentiation of skeletal muscle" [J:18048] is_a: MT:0000733 ! muscle development [Term] id: MT:0000737 name: myotome development namespace: Trait.ontology def: "malformation of or absence of the part of the somite that develops into the musculature" [J:29279, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000729 ! myogenesis [Term] id: MT:0000740 name: smooth muscle contractility namespace: Trait.ontology def: "inability or reduced ability of the smooth muscle to shorten or to develop increased tension" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0005620 ! muscle contractility [Term] id: MT:0000741 name: detrusor smooth muscle contractility namespace: Trait.ontology def: "inability or reduced ability of the detrusor smooth muscle to shorten or to develop increased tension" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000740 ! smooth muscle contractility [Term] id: MT:0000742 name: ileal smooth muscle contractility namespace: Trait.ontology def: "inability or reduced ability of the ileal smooth muscle to shorten or to develop increased tension" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0004005 ! intestinal smooth muscle contractility [Term] id: MT:0000743 name: muscle spasms namespace: Trait.ontology alt_id: MT:0000744 def: "muscular twitching, cramps and seizures ; frequently associated with calcium deficiency, hypoparathyroidism, vitamin D deficiency or alkalosis " [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] synonym: "muscle tetany" EXACT [] synonym: "muscle twitching" EXACT [] synonym: "tetanic cramps" EXACT [] is_a: MT:0002106 ! muscle physiology [Term] id: MT:0000747 name: muscle strength namespace: Trait.ontology def: "loss of muscle strength" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0002106 ! muscle physiology [Term] id: MT:0000748 name: progressive muscle weakness namespace: Trait.ontology def: "increasing loss of strength over time" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, J:67994] is_a: MT:0000747 ! muscle strength [Term] id: MT:0000749 name: muscle integrity namespace: Trait.ontology def: "pathological deterioration of muscle tissue, often accompanied by loss of function" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0002106 ! muscle physiology [Term] id: MT:0000750 name: muscle regeneration namespace: Trait.ontology alt_id: MT:0002547 def: "inability or defects in ability to repair muscle after injuries" [J:42574] synonym: "muscle regeneration" EXACT [] synonym: "muscle regeneration abnormalities" EXACT [] is_a: MT:0002106 ! muscle physiology [Term] id: MT:0000751 name: skeletal muscle integrity namespace: Trait.ontology def: "any abnormal condition or disease of the skeletal muscle" [J:42574, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000749 ! muscle integrity [Term] id: MT:0000753 name: ability to move namespace: Trait.ontology is_a: MT:0001388 ! stationary movement [Term] id: MT:0000755 name: ability to move the hindlimbs namespace: Trait.ontology is_a: MT:0000753 ! ability to move [Term] id: MT:0000756 name: ability to move the forelimbs namespace: Trait.ontology is_a: MT:0000753 ! ability to move [Term] id: MT:0000757 name: herniated abdominal wall namespace: Trait.ontology def: "protrusions through and/or into the abdominal wall often resulting in the extrusion of viscera" [J:40203, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abdominoschisis" EXACT [] synonym: "gastroschisis" EXACT [] synonym: "laparoschisis" EXACT [] synonym: "paraomphalocele" EXACT [] is_a: MT:0003257 ! abdominal wall morphology [Term] id: MT:0000759 name: skeletal muscle morphology namespace: Trait.ontology def: "anomalous structure of any of the striated muscle fibers connected at either or both extremities with the bony framework of the body" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] subset: slim_cattle subset: slim_chkn subset: slim_pig synonym: "abnormal skeletal muscle" EXACT [] synonym: "skeletal muscle abnormalities" EXACT [] is_a: MT:0002108 ! muscle morphology [Term] id: MT:0000761 name: diaphragm muscle thickness namespace: Trait.ontology def: "reduced thickness of the diaphragm muscle" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, J:60159] is_a: MT:0002279 ! diaphragm morphology [Term] id: MT:0000762 name: tongue morphology namespace: Trait.ontology def: "anomalous structure or development of the mobile mass of muscular tissue and surrounding epithelial tissue occupying the cavity of the mouth and forming part of the floor" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal tongue" EXACT [] synonym: "tongue abnormalities" EXACT [] is_a: MT:0000462 ! digestive system morphology [Term] id: MT:0000763 name: filiform papillae morphology namespace: Trait.ontology def: "malformed keratinized projections on the dorsal surface of the tongue" [J:45400] synonym: "abnormal filiform papillae" EXACT [] is_a: MT:0000764 ! tongue epithelium morphology [Term] id: MT:0000764 name: tongue epithelium morphology namespace: Trait.ontology def: "malformation of the epithelial layer of the tongue" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8, tc:Teresa Chu_Mouse Genome Informatics Curator] synonym: "abnormal tongue epithelium" EXACT [] is_a: MT:0000762 ! tongue morphology [Term] id: MT:0000765 name: tongue squamous epithelium morphology namespace: Trait.ontology def: "malformation of the scaly epithelial layer of the tongue" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8, tc:Teresa Chu_Mouse Genome Informatics Curator] synonym: "abnormal tongue squamous epithelium" EXACT [] is_a: MT:0000764 ! tongue epithelium morphology [Term] id: MT:0000767 name: smooth muscle morphology namespace: Trait.ontology def: "anomalous structure of any of the unstriated muscle fibers of the internal organs, blood vessels, hair follicles, etc. " [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "smooth muscle abnormalities" EXACT [] is_a: MT:0002108 ! muscle morphology [Term] id: MT:0000768 name: common crus morphology namespace: Trait.ontology def: "form or sttructure of the united, nonampullary ends of the superior and posterior semicircular ducts of the inner ear" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0002428 ! semicircular canal [Term] id: MT:0000771 name: brain size namespace: Trait.ontology def: "deviation from the average range of brain size for a given strain" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] synonym: "brain size abnormalities" EXACT [] is_a: MT:0002152 ! brain morphology [Term] id: MT:0000776 name: inferior colliculus morphology namespace: Trait.ontology alt_id: MT:0000902 def: "dysmorphology or disorganization of the paired inferior eminence of the mesencephalic tectum that is involved in preliminary visual processing, and control of eye movements" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000899 ! colliculi morphology [Term] id: MT:0000777 name: inferior colliculus size namespace: Trait.ontology alt_id: MT:0000903 def: "enlargement of the paired inferior eminence of the mesencephalic tectum" [J:57538, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000776 ! inferior colliculus morphology is_a: MT:0000900 ! colliculi size [Term] id: MT:0000778 name: tract morphology namespace: Trait.ontology def: "anomaly in the structure of any bundle of myelinated nerve fibers following a defined path through the brain and/or spinal cord" [pvb:Pierre Vanden Borre_Mouse Genome Informatics Curator] is_a: MT:0003632 ! nervous system morphology [Term] id: MT:0000779 name: cochlear basement membrane morphology namespace: Trait.ontology def: "form or structure of the continuous basement membrane found within the membranous labyrinth of the cochlea, known to extend from the limbus, down to the inner sulcus, across the basilar membrane, up to the external sulcus to the spiral prominence and radiating into the spiral ligament enseathing the root cell processes" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0000031 ! cochlea morphology [Term] id: MT:0000780 name: corpus callosum morphology namespace: Trait.ontology def: "malformation or absence of a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres; it consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal corpus callosum" EXACT [] is_a: MT:0000787 ! telencephalon morphology is_a: MT:0002199 ! brain commissure morphology [Term] id: MT:0000781 name: corpus callosum size namespace: Trait.ontology def: "smaller commissural plate interconnecting the cortical hemispheres of the brain" [J:38857, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000780 ! corpus callosum morphology [Term] id: MT:0000783 name: forebrain morphology namespace: Trait.ontology def: "malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [J:38857, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal forebrain" EXACT [] is_a: MT:0002152 ! brain morphology [Term] id: MT:0000784 name: forebrain cell number namespace: Trait.ontology def: "reduced cell number in the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "hypoplastic forebrain" EXACT [] is_a: MT:0000783 ! forebrain morphology [Term] id: MT:0000785 name: telencephalon cell number namespace: Trait.ontology def: "reduced cell number in cerebral cortex and basal ganglia" [J:45302, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "hypoplastic cerebrum" EXACT [] synonym: "hypoplastic telencephalon" EXACT [] is_a: MT:0000787 ! telencephalon morphology [Term] id: MT:0000786 name: neuroepithelial layer differentiation namespace: Trait.ontology def: "malformation or arrest of differentiation or patterning of the epithelial layer of the brain" [J:45302] is_a: MT:0000913 ! brain development is_a: MT:0004261 ! embryonic neuroepithelium morphology [Term] id: MT:0000787 name: telencephalon morphology namespace: Trait.ontology alt_id: MT:0000782 def: "any malformation or absence of the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived " [MeSH:National Library of Medicine_Medical Subject Headings, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal cerebrum" EXACT [] synonym: "abnormal telencephalon" EXACT [] is_a: MT:0000783 ! forebrain morphology [Term] id: MT:0000788 name: cerebral cortex morphology namespace: Trait.ontology def: "malformed gray cellular mantle covering the surface of the brain" [J:38857, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal cerebral cortex" EXACT [] synonym: "abnormal neocortex" EXACT [] is_a: MT:0000787 ! telencephalon morphology [Term] id: MT:0000789 name: thickened cerebral cortex namespace: Trait.ontology def: "Increased depth of the mantle covering the surface of the cerebral hemispheres" [J:49481, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "thickened neocortex" EXACT [] is_a: MT:0000788 ! cerebral cortex morphology [Term] id: MT:0000791 name: cerebral cortex layer morphology namespace: Trait.ontology def: "splitting of the layers of the gray cellular mantle covering the surface of the brain" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, J:38857, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "delaminated neocortex" EXACT [] is_a: MT:0000788 ! cerebral cortex morphology [Term] id: MT:0000792 name: cortical marginal zone morphology namespace: Trait.ontology synonym: "abnormal cortical marginal zone" EXACT [] is_a: MT:0000934 ! telencephalon development [Term] id: MT:0000794 name: parietal lobe morphology namespace: Trait.ontology def: "malformation or absence of the upper central part of the cerebral hemisphere" [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal parietal lobe" EXACT [] is_a: MT:0000788 ! cerebral cortex morphology [Term] id: MT:0000795 name: postcentral gyrus morphology namespace: Trait.ontology def: "malformation or absence of the area of the parietal lobe that receives general sensation from the body" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] synonym: "abnormal postcentral gyrus" EXACT [] is_a: MT:0000794 ! parietal lobe morphology [Term] id: MT:0000796 name: sensory dissociation area morphology namespace: Trait.ontology def: "malformation or absence of the area of the parietal lobe that integrates tactile and visual stimuli" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] synonym: "abnormal sensory dissociation area" EXACT [] is_a: MT:0000794 ! parietal lobe morphology [Term] id: MT:0000797 name: supramarginal gyrus morphology namespace: Trait.ontology def: "malformation or absence of the area of the frontal lobe that is involved in perception based on sensory stimuli" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] synonym: "abnormal supramarginal gyrus" EXACT [] is_a: MT:0000794 ! parietal lobe morphology [Term] id: MT:0000798 name: frontal lobe morphology namespace: Trait.ontology def: "malformation or absence of the anterior part of the cerebral hemisphere" [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal frontal lobe" EXACT [] is_a: MT:0000788 ! cerebral cortex morphology [Term] id: MT:0000799 name: precentral gyrus morphology namespace: Trait.ontology def: "malformation or absence of the area of the frontal lobe that contains the cell bodies of the primary motor pathways" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] synonym: "abnormal primary motor area" EXACT [] is_a: MT:0000798 ! frontal lobe morphology [Term] id: MT:0000800 name: prefrontal gyrus morphology namespace: Trait.ontology def: "malformation or absence of the area of the frontal lobe that is involved with integration of voluntary movements and with speech" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] synonym: "abnormal supplementary motor/speech area" EXACT [] is_a: MT:0000798 ! frontal lobe morphology [Term] id: MT:0000801 name: temporal lobe morphology namespace: Trait.ontology def: "malformation or absence of the lower lateral part of the cerebral hemisphere" [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal temporal lobe" EXACT [] is_a: MT:0000788 ! cerebral cortex morphology [Term] id: MT:0000802 name: superior temporal gyrus morphology namespace: Trait.ontology synonym: "abnormal superior temporal gyrus" EXACT [] is_a: MT:0000801 ! temporal lobe morphology [Term] id: MT:0000803 name: transverse gyrus of Heschl morphology namespace: Trait.ontology def: "malformation or absence of the area of the temporal lobe concerned with hearing" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] synonym: "abnormal primary auditory area" EXACT [] synonym: "abnormal transverse gyrus of Heschl" EXACT [] is_a: MT:0000801 ! temporal lobe morphology [Term] id: MT:0000804 name: occipital lobe morphology namespace: Trait.ontology def: "malformation or absence of the posterior part of the cerebral hemisphere" [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal occipital lobe" EXACT [] is_a: MT:0000788 ! cerebral cortex morphology [Term] id: MT:0000805 name: visual cortex morphology namespace: Trait.ontology def: "malformation or absence of the area of the occipital cortex concerned with vision" [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal striate cortex" EXACT [] synonym: "abnormal striate cortex morphology" EXACT [] is_a: MT:0000804 ! occipital lobe morphology [Term] id: MT:0000807 name: hippocampus morphology namespace: Trait.ontology alt_id: MT:0000806 alt_id: MT:0000810 def: "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, J:38857, The Atlas of Mouse Development:ISBN 0-12-402035-6] synonym: "abnormal hippocampus" EXACT [] synonym: "Hippocampal Defects" EXACT [] synonym: "Hippocampus" EXACT [] is_a: MT:0000787 ! telencephalon morphology is_a: MT:0000801 ! temporal lobe morphology is_a: MT:0004166 ! limbic system morphology [Term] id: MT:0000808 name: hippocampus development namespace: Trait.ontology def: "improper differentiation of the hippocampus" [tc:Teresa Chu_Mouse Genome Informatics Curator] synonym: "Abnormal Hippocampal Development" EXACT [] synonym: "Hippocampal Dysgenesis" EXACT [] is_a: MT:0000807 ! hippocampus morphology is_a: MT:0000913 ! brain development [Term] id: MT:0000811 name: hippocampal neuron integrity namespace: Trait.ontology def: "a retrogressive impairment of function or destruction of the neuronal cells in the hippocampus" [cml:Cathleen M. Lutz_Mouse Genome Informatics Curator, J:72427] synonym: "degenerating hippocampal neurons" EXACT [] is_a: MT:0002181 ! brain cell morphology is_a: MT:0002882 ! neuron is_a: MT:0003224 ! neuron integrity [Term] id: MT:0000812 name: dentate gyrus morphology namespace: Trait.ontology def: "absence or malformation of one of two interlocking gyri of the hippocampus that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, J:38857, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal dentate gyrus" EXACT [] is_a: MT:0000807 ! hippocampus morphology [Term] id: MT:0000813 name: hippocampal laminar structure namespace: Trait.ontology def: "malformed or missing layers of the laminar structure of the hippocampus" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, J:38857, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal laminar structure" EXACT [] is_a: MT:0000807 ! hippocampus morphology [Term] id: MT:0000815 name: ammon gyrus morphology namespace: Trait.ontology def: "malformations of one of the two interlocking gyri of the hippocampus; a circonvolution of rhinencephalon, the grey substance of which is rich in big pyramidal neuronal cells " [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal ammon gyrus" EXACT [] synonym: "abnormal Ammon horn" EXACT [] synonym: "abnormal Ammon's horn" EXACT [] is_a: MT:0000807 ! hippocampus morphology [Term] id: MT:0000816 name: cochlear hair cell stereociliary bundle morphology namespace: Trait.ontology def: "form or structure of he typical pattern of arrangement of mechanosensitive hair bundles which are composed of thick long microvilli (stereocilia) and are located at the apical end of cochlear inner and outer hair cells" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0002622 ! cochlear hair cell morphology [Term] id: MT:0000818 name: amygdala morphology namespace: Trait.ontology def: "any malformation or absence of the almond-shaped body of basal nuclei anterior to the inferior horn of the lateral ventricle of the brain, within the temporal lobe; this area is involved in aggression and fear responses" [MeSH:National Library of Medicine_Medical Subject Headings, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal amygdala" EXACT [] is_a: MT:0004166 ! limbic system morphology [Term] id: MT:0000819 name: olfactory bulb morphology namespace: Trait.ontology alt_id: MT:0000943 def: "malformation or absence of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [J:16461, Principles of Neural Science:ISBN 0-8385-8034-3, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal olfactory bulb" EXACT [] is_a: MT:0005235 ! olfactory pathway morphology [Term] id: MT:0000820 name: choroid plexus morphology namespace: Trait.ontology def: "malformed or absent fringe of the tela choroidea of the cerebral ventricles" [J:45302, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal choroid plexus" EXACT [] is_a: MT:0002200 ! brain ventricle/choroid plexus morphology [Term] id: MT:0000821 name: choroid plexus cell number namespace: Trait.ontology def: "increased cell number in the tela choroidea of the cerebral ventricles" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, J:49840, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "hyperplastic choroid plexus" EXACT [] is_a: MT:0000820 ! choroid plexus morphology [Term] id: MT:0000822 name: brain ventricle morphology namespace: Trait.ontology def: "malformed or absent fluid filled cavities of the cerebrum" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal brain ventricle" EXACT [] synonym: "abnormal ventricle" EXACT [] is_a: MT:0002200 ! brain ventricle/choroid plexus morphology [Term] id: MT:0000823 name: lateral ventricle morphology namespace: Trait.ontology def: "malformation or absence of cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal lateral ventricles" EXACT [] is_a: MT:0000787 ! telencephalon morphology is_a: MT:0000822 ! brain ventricle morphology [Term] id: MT:0000825 name: lateral ventricle size namespace: Trait.ontology alt_id: MT:0000824 def: "increase over the normal size of the horseshoe-shaped cavities of the cerebrum" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, J:38857, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "dilated ventricle of cerebral hemisphere" EXACT [] synonym: "dilated ventriculus lateralis" EXACT [] synonym: "enlarged lateral ventricles" EXACT [] is_a: MT:0000823 ! lateral ventricle morphology [Term] id: MT:0000826 name: third ventricle morphology namespace: Trait.ontology def: "malformation or absence of the narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami; its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma; it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal third ventricle" EXACT [] is_a: MT:0000822 ! brain ventricle morphology is_a: MT:0000830 ! diencephalon morphology [Term] id: MT:0000827 name: third ventricle size namespace: Trait.ontology def: "enlarged narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami; its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma; it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] synonym: "dilated ventricle of diencephalon" EXACT [] synonym: "dilated ventriculus tertius" EXACT [] synonym: "enlarged third ventricle" EXACT [] is_a: MT:0000826 ! third ventricle morphology [Term] id: MT:0000828 name: fourth ventricle morphology namespace: Trait.ontology def: "malformed or absent irregularly shaped cavity in the rhombencephalon, between the medulla oblongata, the pons, and the isthmus in front, and the cerebellum behind; it is continuous with the central canal of the cord below and with the cerebral aqueduct above, and through its lateral and median apertures it communicates with the subarachnoid space" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal fourth ventricle" EXACT [] synonym: "abnormal ventricle of rhombencephalon morphology" EXACT [] synonym: "abnormal ventriculus quartus morphology" EXACT [] is_a: MT:0000822 ! brain ventricle morphology is_a: MT:0000841 ! hindbrain morphology [Term] id: MT:0000829 name: fourth ventricle size namespace: Trait.ontology def: "enlarged irregularly shaped cavity in the rhombencephalon, between the medulla oblongata, the pons, and the isthmus in front, and the cerebellum behind; it is continuous with the central canal of the cord below and with the cerebral aqueduct above, and through its lateral and median apertures it communicates with the subarachnoid space" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] synonym: "dilated ventricle of rhombencephalon" EXACT [] synonym: "dilated ventriculus quartus" EXACT [] synonym: "enlarged fourth ventricle" EXACT [] is_a: MT:0000828 ! fourth ventricle morphology [Term] id: MT:0000830 name: diencephalon morphology namespace: Trait.ontology def: "any malformation or absence of the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex" [MeSH:National Library of Medicine_Medical Subject Headings, Principles of Neural Science_3rd edition:ISBN 0-8385-8034-3] synonym: "abnormal diencephalon" EXACT [] is_a: MT:0000783 ! forebrain morphology [Term] id: MT:0000831 name: diencephalon cell number namespace: Trait.ontology def: "increased cell number in the rostral portion of the brain stem" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, J:49840, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "hyperplastic diencephalon" EXACT [] is_a: MT:0000830 ! diencephalon morphology [Term] id: MT:0000832 name: thalamus morphology namespace: Trait.ontology def: "malformation or absence of the large ovoid mass of paired bodies containing mostly gray matter and forming part of the lateral wall of the third ventricle of the brain" [MeSH:National Library of Medicine_Medical Subject Headings, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal thalamus" EXACT [] is_a: MT:0000830 ! diencephalon morphology [Term] id: MT:0000833 name: thalamus cell number namespace: Trait.ontology def: "increased cell number in the thalamus" [J:49481, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "hyperplastic thalamus" EXACT [] is_a: MT:0000832 ! thalamus morphology [Term] id: MT:0000834 name: subthalamus morphology namespace: Trait.ontology def: "any malformation or absence of the anterior part of the diencephalon that lies between the thalamus, hypothalamus, and tegmentum of the mesencephalon, including subthalamic nucleus, zona incerta, the fields of Forel, and the nucleus of ansa lenticularis" [MeSH:National Library of Medicine_Medical Subject Headings, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal subthalamus" EXACT [] synonym: "abnormal ventral thalamus" EXACT [] is_a: MT:0000830 ! diencephalon morphology [Term] id: MT:0000835 name: subthalamic nucleus morphology namespace: Trait.ontology def: "any malformation or absence of the lens-shaped nucleus located in the ventral part of the subthalamus on the inner aspect of the internal capsule that is concerned with the integration of somatic motor function" [MeSH:National Library of Medicine_Medical Subject Headings, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal corpus luysi" EXACT [] synonym: "abnormal subthalamic nucleus" EXACT [] is_a: MT:0000834 ! subthalamus morphology is_a: MT:0006007 ! basal ganglion morphology [Term] id: MT:0000836 name: substantia nigra morphology namespace: Trait.ontology def: "malformation or absence of the layer of gray substance that separates the posterior parts of the cerebral peduncles (tegmentum mesencephali) from the anterior parts; it normally includes a posterior compact part with many pigmented cells (pars compacta) and an anterior reticular part whose cells contain little pigment (pars reticularis)" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal locus niger" EXACT [] synonym: "abnormal nucleus niger" EXACT [] synonym: "abnormal substantia nigra" EXACT [] is_a: MT:0000834 ! subthalamus morphology is_a: MT:0006007 ! basal ganglion morphology [Term] id: MT:0000837 name: hypothalamus morphology namespace: Trait.ontology def: "any malformation or absence of the ventral part of the diencephalon extending from the region of the optic chiasm to the caudal border of the mammillary bodies and forming the inferior and lateral walls of the third ventricle; this region regulates the autonomic nervous system via hormone production and release" [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal hypothalamus" EXACT [] is_a: MT:0000830 ! diencephalon morphology is_a: MT:0004166 ! limbic system morphology [Term] id: MT:0000838 name: cochlear hair cell inter-stereocilial links namespace: Trait.ontology def: "form or structure of the morphologically and biochemically distinct link types that extend between the stereocilia of cochlear hair bundles; link types can be distinguished by their relative sensitivities to treatment with calcium chelators and the protease subtilisin; in the mature mouse cochlea, tip links and horizontal top connectors are the only inter-stereocilial links associated with the hair bundle; ankle links and transient lateral links are both prominent features of developing auditory hair bundles" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0000816 ! cochlear hair cell stereociliary bundle morphology [Term] id: MT:0000839 name: hypothalamus cell number namespace: Trait.ontology def: "increased cell number in the hypothalamus" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, J:49840, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "hyperplastic hypothalamus" EXACT [] is_a: MT:0000837 ! hypothalamus morphology [Term] id: MT:0000840 name: epithalamus morphology namespace: Trait.ontology def: "any malformation or absence of the small dorsomedial area of the thalamus including the habenular nuclei and associated fiber bundles, the pineal body, and the epithelial roof of the third ventricle" [MeSH:National Library of Medicine_Medical Subject Headings, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000830 ! diencephalon morphology [Term] id: MT:0000841 name: hindbrain morphology namespace: Trait.ontology def: "malformed caudal region of the brain; includes cerebellum, pons and medulla oblongata" [J:45302, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002152 ! brain morphology [Term] id: MT:0000842 name: superior olivary complex morphology namespace: Trait.ontology def: "form or structure of the nucleus of neurons on the dorsal part of the lateral surface of the pons; it normally receives projection fibers from the cochlear nuclei and is prominently involved in spatial localization of sound " [J:1776, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000848 ! pons morphology [Term] id: MT:0000843 name: facial nuclei cell number namespace: Trait.ontology def: "missing nucleus of neurons in the hindbrain; receives fibers from the facial muscles, stapedus muscle and stylohyoid muscle" [J:1776, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000909 ! facial motor nucleus morphology [Term] id: MT:0000844 name: pontine flexure morphology namespace: Trait.ontology def: "malformation or absence of the bend in the developing neural tube that produces a thinning of the roof of the pons and medulla oblongata and defines the boundary between the metencephalon and medulla oblongata in the embryo" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0000841 ! hindbrain morphology is_a: MT:0000913 ! brain development [Term] id: MT:0000846 name: medulla oblongata namespace: Trait.ontology alt_id: MT:0000845 def: "anomaly in the most caudal region of the brainstem that lies directly rostral to the spinal cord; includes regions responsible for autonomic functions such as digestion, breathing and control of heart rate" [Principles of Neural Science_3rd edition:ISBN 0-8385-8034-3] synonym: "abnormal myelencephalon" EXACT [] is_a: MT:0000841 ! hindbrain morphology [Term] id: MT:0000847 name: metencephalon morphology namespace: Trait.ontology def: "any malformation or absence of the anterior part of the rhombencephalon" [MeSH:National Library of Medicine_Medical Subject Headings, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal metencephalon" EXACT [] is_a: MT:0000841 ! hindbrain morphology [Term] id: MT:0000848 name: pons morphology namespace: Trait.ontology def: "malformed band of nerve fibers in the brain connecting the medulla oblongata and the mesencephalon; this region conveys information about movement from the cerebral hemisphere to the cerebellum" [J:1776, Principles of Neural Science_3rd edition:ISBN 0-8385-8034-3, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000841 ! hindbrain morphology [Term] id: MT:0000849 name: cerebellum morphology namespace: Trait.ontology def: "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science_3rd edition:ISBN 0-8385-8034-3] synonym: "abnormal cerebellar hemispheres" EXACT [] synonym: "abnormal cerebellum" EXACT [] is_a: MT:0000841 ! hindbrain morphology [Term] id: MT:0000851 name: cerebellum cell number namespace: Trait.ontology def: "reduced cell number in the cerebellum" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, J:45302] synonym: "hypoplastic cerebellum" EXACT [] is_a: MT:0000852 ! cerebellum size [Term] id: MT:0000852 name: cerebellum size namespace: Trait.ontology def: "reduced size of cerebellum" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, J:17203, J:67524] is_a: MT:0000849 ! cerebellum morphology [Term] id: MT:0000854 name: cerebellum development namespace: Trait.ontology def: "malformed or incomplete differentiation of the part of the metencephalon that lies dorsal to the pons and medulla behind the brain stem and controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills " [MeSH:National Library of Medicine_Medical Subject Headings, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal cerebellar development" EXACT [] is_a: MT:0000849 ! cerebellum morphology is_a: MT:0000913 ! brain development [Term] id: MT:0000855 name: formation of intralobular fissures namespace: Trait.ontology def: "formation of the major fissures of the cerebellum earlier in development than normal" [J:56546] is_a: MT:0000854 ! cerebellum development [Term] id: MT:0000856 name: cerebellar plate morphology namespace: Trait.ontology def: "malformed embryonic pseudostratified epithelium of the fourth cerebellar ventricle that eventually forms the vermis and ventral neuroepithelium" [J:45302] synonym: "abnormal cerebellar plate" EXACT [] is_a: MT:0000854 ! cerebellum development [Term] id: MT:0000857 name: cerebellar foliation namespace: Trait.ontology def: "malformation of small offshoots of the cerebellar lobules" [J:52951, Principles of Neural Science:ISBN 0-8385-8034-3] is_a: MT:0000854 ! cerebellum development [Term] id: MT:0000858 name: metastatic potential namespace: Trait.ontology def: "altered likelihood of a tumor cell spreading from the site of the initial tumour formation and forming a secondary tumor at another site not directly connected with it" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0002166 ! tumor susceptibility [Term] id: MT:0000859 name: somatosensory cortex morphology namespace: Trait.ontology def: "any malformation or absence of the area of the parietal lobe that lies posterior to the central sulcus and is concerned with receiving and processing general sensations from the body surface" [MeSH:National Library of Medicine_Medical Subject Headings, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000788 ! cerebral cortex morphology [Term] id: MT:0000860 name: primary somatosensory cortex morphology namespace: Trait.ontology def: "any malformation or absence of the area of the postcentral gyrus and central sulcus that is involved in somatic sensation" [Principles of Neural Science_3rd edition:ISBN 0-8385-8034-3] is_a: MT:0000859 ! somatosensory cortex morphology [Term] id: MT:0000861 name: barrel cortex organization namespace: Trait.ontology def: "arrangement of the pattern of the discrete functional units of the somatosensory cortex that processes tactile information derived from the vibrissae" [J:64064, Principles of Neural Science:ISBN 0-8385-8034-3] is_a: MT:0003989 ! barrel cortex morphology [Term] id: MT:0000863 name: secondary somatosensory cortex morphology namespace: Trait.ontology def: "any malformation or absence of the area of the upper bank of the lateral sulcus that is involved in somatic sensation" [Principles of Neural Science_3rd edition:ISBN 0-8385-8034-3] is_a: MT:0000859 ! somatosensory cortex morphology [Term] id: MT:0000864 name: vermis morphology namespace: Trait.ontology def: "malformation in the narrow middle zone between the two hemispheres of the cerebellum" [J:61509, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000849 ! cerebellum morphology [Term] id: MT:0000865 name: vermis size namespace: Trait.ontology def: "length, width, or area of the narrow middle zone between the two hemispheres of the cerebellum" [J:45302, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000864 ! vermis morphology [Term] id: MT:0000866 name: vermis cell number namespace: Trait.ontology def: "reduced cell number in the vermis" [J:61509] synonym: "hypoplastic vermis" EXACT [] is_a: MT:0000864 ! vermis morphology [Term] id: MT:0000867 name: anterior vermis morphology namespace: Trait.ontology def: "malformation in the anterior portion of the narrow middle zone between the two hemispheres of the cerebellum" [J:61509, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000864 ! vermis morphology [Term] id: MT:0000868 name: anterior vermis size namespace: Trait.ontology def: "smaller appearance of the narrow middle zone between the two hemispheres of the cerebellum" [J:57538, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000867 ! anterior vermis morphology [Term] id: MT:0000869 name: posterior vermis morphology namespace: Trait.ontology def: "malformation in the posterior portion of the narrow middle zone between the two hemispheres of the cerebellum" [J:61509, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000864 ! vermis morphology [Term] id: MT:0000870 name: vermal pyramis morphology namespace: Trait.ontology def: "form or structure of part of the inferior vermis of the cerebellum (vermis lobule VIII)" [J:61509, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "absence of vermal pyramis" EXACT [] is_a: MT:0000864 ! vermis morphology [Term] id: MT:0000871 name: vermal uvula morphology namespace: Trait.ontology def: "form or structure of the triangular elevation on the vermis of the cerebellum" [J:61509, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "absence of vermal uvula" EXACT [] is_a: MT:0000864 ! vermis morphology [Term] id: MT:0000872 name: external granule cell layer morphology namespace: Trait.ontology def: "malformation of the transient layer of the cerebellar cortex which is composed of the dividing and migrating granule cells" [tc:Teresa Chu_Mouse Genome Informatics Curator] synonym: "Abnormal EGL" EXACT [] synonym: "Abnormal External Germinal Layer" EXACT [] is_a: MT:0000854 ! cerebellum development [Term] id: MT:0000873 name: external granule cell layer thickness namespace: Trait.ontology def: "reduced thickness of the transient layer of the cerebellar cortex which is composed of dividing and migrating granule cells" [J:60896, tc:Teresa Chu_Mouse Genome Informatics Curator] synonym: "Thin EGL" EXACT [] synonym: "Thin External Germinal Layer" EXACT [] is_a: MT:0000872 ! external granule cell layer morphology [Term] id: MT:0000875 name: cerebellar Purkinje cell layer morphology namespace: Trait.ontology def: "any malformation or absence of the cell layer that lies just underneath the molecular layer of the cerebellar cortex; it contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer, and candelabrum interneurons are vertically oriented between the Purkinje cells" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal Purkinje cell layer" EXACT [] is_a: MT:0004097 ! cerebellar cortex morphology [Term] id: MT:0000876 name: Purkinje cell integrity namespace: Trait.ontology def: "a retrogressive impairment of function or destruction of the large neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex" [J:46854] is_a: MT:0000877 ! Purkinje cell morphology is_a: MT:0003224 ! neuron integrity [Term] id: MT:0000877 name: Purkinje cell morphology namespace: Trait.ontology def: "any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [J:46140, Principles of Neural Science_3rd edition:ISBN 0-8385-8034-3] synonym: "abnormal Purkinje cells" EXACT [] is_a: MT:0000875 ! cerebellar Purkinje cell layer morphology is_a: MT:0002882 ! neuron [Term] id: MT:0000878 name: Purkinje cell number namespace: Trait.ontology def: "different from average number of neuronal cells that are located in the interface of the molecular and granular layers of the cerebellar cortex" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000877 ! Purkinje cell morphology [Term] id: MT:0000881 name: cochlear hair bundle ankle links namespace: Trait.ontology def: "form or internal structure of the long, single-stranded filaments that form a dense web or mesh around the base of cochlear hair bundles just above the region in which the stereocilia begin to taper down; in the mouse, ankle links are only a transient feature of the developing cochlear hair bundles, present predominantly from P2 though P9, but are absent by P12; ankle links are disrupted by treatment of hair cells with EGTA and subtilisin but not by La^3+ and elastase" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0000838 ! cochlear hair cell inter-stereocilial links [Term] id: MT:0000882 name: cochlear hair bundle horizontal top connectors namespace: Trait.ontology def: "form or internal structure of the inter-stereocilial links that connect the top of a shorter stereocilium to an adjacent longer stereocilium at a short distance below the tip links; the appearance of horizontal top connectors, which persist into adulthood, occurs concomitant with this loss of ankle links; top connectors are essentially unaffected by treatment with subtilisin and EGTA" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0000838 ! cochlear hair cell inter-stereocilial links [Term] id: MT:0000883 name: cochlear hair bundle tip links namespace: Trait.ontology def: "form or internal structure of the single, three-stranded interrow filaments that extend obliquely from the tip of one stereocilium to the lateral side of an adjacent taller stereocilium; in the mouse, tip links are already detectable at E17 and persist throughout life; tips links are thought to gate the mechanotransducer channel, are lost from the cell surface after exposure to either calcium chelator BAPTA or lanthanum, and resist degradation by the protease subtilisin" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0000838 ! cochlear hair cell inter-stereocilial links [Term] id: MT:0000884 name: Purkinje cell layer lamination namespace: Trait.ontology def: "splitting or disorganization of the layer of large neuron cell bodies between the molecular and granular layers of the cerebellum" [J:61509, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000875 ! cerebellar Purkinje cell layer morphology [Term] id: MT:0000885 name: ectopic Purkinje cell namespace: Trait.ontology def: "Purkinje cell body resides in places other than the Purkinje cell layer in the cerebellum" [J:60896, tc:Teresa Chu_Mouse Genome Informatics Curator] synonym: "ectopic Purkinje cell" EXACT [] synonym: "heterotopic Purkinje cell" EXACT [] is_a: MT:0000877 ! Purkinje cell morphology [Term] id: MT:0000886 name: cerebellar granule layer morphology namespace: Trait.ontology def: "any malformation or absence of the innermost cortical layer of the cerebellum; contains densely packed small neurons, mostly granule cells with some Golgi cells are found at the outer border" [Principles of Neural Science_3rd edition:ISBN 0-8385-8034-3, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal granule layer" EXACT [] synonym: "abnormal IGL" EXACT [] synonym: "abnormal internal granule layer" EXACT [] is_a: MT:0004097 ! cerebellar cortex morphology [Term] id: MT:0000887 name: granule layer lamination namespace: Trait.ontology def: "splitting or disorganization of the deepest of the three layers of the cerebellum that contains granule cells" [J:61509, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "delaminated internal granule layer" EXACT [] is_a: MT:0000886 ! cerebellar granule layer morphology [Term] id: MT:0000889 name: cerebellar molecular layer morphology namespace: Trait.ontology def: "any malformation or absence of the outermost layer of the cerebral cortex that contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells" [J:38857, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal molecular layer" EXACT [] is_a: MT:0004097 ! cerebellar cortex morphology [Term] id: MT:0000890 name: cerebellar molecular layer thickness namespace: Trait.ontology def: "reduced width of the outer of the three cortical layers of the cerebellum" [J:46854] is_a: MT:0000889 ! cerebellar molecular layer morphology [Term] id: MT:0000891 name: cochlear hair bundle transient lateral links namespace: Trait.ontology def: "form or internal structure of the fine lateral links that interconnect stereocilia at E17.5; transient lateral links diminish at early postnatal stages (P2) when ankle links appear at the base of stereocilia, and are essentially unaffected by treatment with subtilisin and EGTA" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0000838 ! cochlear hair cell inter-stereocilial links [Term] id: MT:0000892 name: orientation of cochlear hair cell stereociliary bundles namespace: Trait.ontology def: "rotational direction of inner and/or outer hair cell stereociliary bundles, resulting in planar cell polarity of the inner ear sensory epithelium" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0000816 ! cochlear hair cell stereociliary bundle morphology [Term] id: MT:0000893 name: cochlear hair cell stereocilia number namespace: Trait.ontology def: "number of the nonmotile, actin-filled specialized microvilli (stereocilia) normally arrayed on cochlear inner and outer hair cells" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0000816 ! cochlear hair cell stereociliary bundle morphology [Term] id: MT:0000894 name: cochlear hair cell stereocilia size namespace: Trait.ontology def: "length, width, or volume of the nonmotile, actin-filled specialized microvilli (stereocilia) which are normally arrayed on cochlear inner and outer hair cells" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0000816 ! cochlear hair cell stereociliary bundle morphology [Term] id: MT:0000895 name: cochlear IHC afferent innervation namespace: Trait.ontology def: "the form, internal structure, or number of afferent terminals and/or their synapses in the cochlear IHC region" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0000968 ! sensory neuron innervation is_a: MT:0004393 ! cochlear inner hair cell morphology [Term] id: MT:0000896 name: cochlear IHC efferent innervation namespace: Trait.ontology def: "the form, internal structure, or number of the normally dense plexus of efferent terminals that contact radial fibers of the spiral ganglion below cochlear IHCs or of the sparser plexus of terminals positioned around IHC somata; normally, lateral olivocochlear neurons, which are found in and/or around the lateral superior olive, project mainly to the ipsilateral cochlea and terminate mostly on dendritic fibers below IHCs" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0000968 ! sensory neuron innervation is_a: MT:0004393 ! cochlear inner hair cell morphology [Term] id: MT:0000897 name: midbrain morphology namespace: Trait.ontology def: "malformation or malfunction associated with the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions, including eye movement and coordination of auditory and visual reflexes" [J:23882, Principles of Neural Science_3rd edition:ISBN 0-8385-8034-3] synonym: "abnormal mesencephalon" EXACT [] is_a: MT:0002152 ! brain morphology [Term] id: MT:0000898 name: midbrain cell number namespace: Trait.ontology def: "increased cell number associated with the middle of the three cerebral vesicles of the embryo" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, J:49840, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "hyperplastic midbrain" EXACT [] is_a: MT:0000897 ! midbrain morphology [Term] id: MT:0000899 name: colliculi morphology namespace: Trait.ontology def: "malformed inferior and superior colliculus" [J:50311] is_a: MT:0006104 ! tectum morphology [Term] id: MT:0000900 name: colliculi size namespace: Trait.ontology def: "smaller inferior and superior colliculus" [J:19212, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000899 ! colliculi morphology [Term] id: MT:0000901 name: position of colliculi namespace: Trait.ontology def: "positional abnormality of the inferior and superior colliculus" [J:57538] is_a: MT:0000899 ! colliculi morphology [Term] id: MT:0000904 name: superior colliculus namespace: Trait.ontology def: "dysmorphology or disorganization of the paired superior eminence of the mesencephalic tectum that is involved in auditory processing" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000899 ! colliculi morphology [Term] id: MT:0000905 name: superior colliculus size namespace: Trait.ontology def: "enlargement of the paired superior eminence of the mesencephalic tectum" [J:57538, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000900 ! colliculi size is_a: MT:0000904 ! superior colliculus [Term] id: MT:0000906 name: mesencephalic trigeminal nucleus namespace: Trait.ontology def: "malformation or disorganization of the group of sensory neurons residing in a long, narrow plate in the midbrain; axons pass with the trigeminal nerve" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000897 ! midbrain morphology [Term] id: MT:0000907 name: mesencephalic trigeminal nucleus size namespace: Trait.ontology def: "reduced size of the group of sensory neurons residing in a long, narrow plate in the midbrain; axons pass with the trigeminal nerve" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, J:60159, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000906 ! mesencephalic trigeminal nucleus [Term] id: MT:0000909 name: facial motor nucleus morphology namespace: Trait.ontology def: "malformation or disorganization of the group of motor neurons residing in the pons that innervate the muscles of facial expression" [Principles of Neural Science_3rd edition:ISBN 0-8385-8034-3] synonym: "abnormal motor nucleus, facial" EXACT [] is_a: MT:0000848 ! pons morphology [Term] id: MT:0000910 name: facial motor nucleus size namespace: Trait.ontology def: "reduced size of the group of motor neurons residing in the pons that innervate the muscles of facial expression" [J:56847, Principles of Neural Science:ISBN 0-8385-8034-3] synonym: "small motor nucleus, facial" EXACT [] is_a: MT:0000909 ! facial motor nucleus morphology [Term] id: MT:0000911 name: trigeminal motor nucleus morphology namespace: Trait.ontology def: "malformation or disorganization of the group of motor neurons innervating the muscles of mastication" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal motor nucleus, trigeminal" EXACT [] is_a: MT:0000848 ! pons morphology [Term] id: MT:0000912 name: trigeminal motor nucleus size namespace: Trait.ontology def: "reduced size of the group of motor neurons innervating the muscles of mastication" [J:18984, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "small motor nucleus, trigeminal" EXACT [] is_a: MT:0000911 ! trigeminal motor nucleus morphology [Term] id: MT:0000913 name: brain development namespace: Trait.ontology alt_id: MT:0001888 def: "malformed or incomplete differentiation of the brain" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, J:49840] synonym: "brain development abnormalities" EXACT [] xref: GO:0007420 is_a: MT:0002152 ! brain morphology is_a: MT:0003861 ! nervous system development [Term] id: MT:0000914 name: exencephaly namespace: Trait.ontology def: "neurocranial defects resulting in exposure or extrusion of the brain" [J:49840, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000913 ! brain development [Term] id: MT:0000917 name: obstructive hydrocephaly namespace: Trait.ontology alt_id: MT:0001892 def: "hydrocephaly due to a block in cerebrospinal fluid flow in the ventricular system" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "obstructive hydrocephalus" EXACT [] is_a: MT:0001891 ! hydroencephaly [Term] id: MT:0000919 name: cranioschisis namespace: Trait.ontology def: "incomplete closure of the skull, usually congenital " [J:60409, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000438 ! skull morphology [Term] id: MT:0000920 name: myelination namespace: Trait.ontology alt_id: MT:0001894 def: "atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] synonym: "altered myelination" EXACT [] synonym: "myelination abnormalities" EXACT [] synonym: "myelination defect" EXACT [] is_a: MT:0003633 ! nervous system physiology [Term] id: MT:0000921 name: demyelination namespace: Trait.ontology def: "loss of the myelin sheath without loss of axons or fiber tracts" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000920 ! myelination [Term] id: MT:0000923 name: roof plate morphology namespace: Trait.ontology def: "malformation or absence of a transient group of neuroepithelial cells located at the dorsal midline of the neural tube that profoundly influences the development of the vertebrate central nervous system" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] synonym: "abnormal roof plate" EXACT [] synonym: "roof plate abnormalities" EXACT [] is_a: MT:0002151 ! neural tube morphology/development [Term] id: MT:0000925 name: floor plate morphology namespace: Trait.ontology def: "malformation or absence of a transient group of neuroepithelial cells located at the ventral midline of the neural tube that profoundly influences the development of the vertebrate central nervous system" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] synonym: "abnormal floor plate" EXACT [] synonym: "floor plate abnormalities" EXACT [] is_a: MT:0002151 ! neural tube morphology/development [Term] id: MT:0000927 name: floor plate size namespace: Trait.ontology def: "reduced size of the floor plate" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000925 ! floor plate morphology [Term] id: MT:0000928 name: incomplete cephalic closure namespace: Trait.ontology def: "arrest of the fusion of the cephalic neural folds" [J:12622] is_a: MT:0003720 ! neural tube closure [Term] id: MT:0000929 name: open neural tube namespace: Trait.ontology alt_id: MT:0000931 alt_id: MT:0005436 def: "incomplete invagination and fusion of the neuroepithelial layer in early development" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, J:53370, J:62571] synonym: "failure of neural tube closure" EXACT [] synonym: "hydrocele spinalis" EXACT [] synonym: "schistorrhachis" EXACT [] synonym: "spina bifida" EXACT [] is_a: MT:0003720 ! neural tube closure [Term] id: MT:0000930 name: wavy neural tube namespace: Trait.ontology def: "undulations in the embryonic neural tube" [J:37888] is_a: MT:0002151 ! neural tube morphology/development [Term] id: MT:0000933 name: rhombomere morphology namespace: Trait.ontology def: "malformation of the transverse segments in the hindbrain region of the developing neural tube" [J:1776, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal rhombomeres" EXACT [] is_a: MT:0003208 ! neuromere morphology is_a: MT:0006108 ! hindbrain development [Term] id: MT:0000934 name: telencephalon development namespace: Trait.ontology def: "malformed or incomplete differentiation of the anterior division of the embryonic prosencephalon " [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, J:49840, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000787 ! telencephalon morphology is_a: MT:0003232 ! forebrain development [Term] id: MT:0000935 name: folding of telencephalic vesicles namespace: Trait.ontology def: "malformation of the stereotypic invaginations forming the paired diverticula of the telencephalon" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, J:49840, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000934 ! telencephalon development [Term] id: MT:0000936 name: telencephalic vesicles size namespace: Trait.ontology def: "reduced size of the paired diverticula of the telencephalon, from which the forebrain develops" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, J:49840, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000934 ! telencephalon development [Term] id: MT:0000937 name: motor neuron morphology namespace: Trait.ontology def: "malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of motor impulses" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, J:60159, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal motor neuron" EXACT [] synonym: "motor neuron abnormalities" EXACT [] is_a: MT:0000955 ! spinal cord morphology is_a: MT:0002882 ! neuron [Term] id: MT:0000938 name: motor neuron integrity namespace: Trait.ontology def: "retrogressive impairment of function or destruction of the cells that innervate an effector (muscle or glandular) tissue" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] synonym: "loss of motor neurons" EXACT [] is_a: MT:0000937 ! motor neuron morphology is_a: MT:0003224 ! neuron integrity [Term] id: MT:0000939 name: motor neuron number namespace: Trait.ontology def: "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, J:60159, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000937 ! motor neuron morphology [Term] id: MT:0000940 name: motor neuron innervation namespace: Trait.ontology def: "misprojection or failure to bundle motor axons to an effector tissue" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, J:60159, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal motor neuron projections" EXACT [] is_a: MT:0000937 ! motor neuron morphology is_a: MT:0002184 ! innervation [Term] id: MT:0000941 name: motor neuron target finding namespace: Trait.ontology def: "failure of innervating neuron to stop at target site and form terminal arbors " [J:47439] is_a: MT:0000937 ! motor neuron morphology [Term] id: MT:0000942 name: motor neuron axon growth namespace: Trait.ontology def: "innervating motor neuron projections grow past typical endplate target and extend to myotendenous ends of muscle" [J:33132] synonym: "excessive motor neuron growth" EXACT [] is_a: MT:0000937 ! motor neuron morphology [Term] id: MT:0000944 name: cochlear OHC afferent innervation namespace: Trait.ontology def: "the form, internal structure, or number of afferent terminals and/or their synapses in the cochlear OHC region" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0004399 ! cochlear outer hair cell morphology [Term] id: MT:0000952 name: CNS glia morphology namespace: Trait.ontology def: "anomalous structure, number or composition of non-neuronal cells of the central nervous system that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons" [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal CNS glia morphology" EXACT [] synonym: "CNS glia abnormalities" EXACT [] is_a: MT:0003634 ! glia morphology [Term] id: MT:0000953 name: oligodendrocyte morphology namespace: Trait.ontology def: "anomalous structure, number or composition of the neuroglia of the central nervous system that form the insulating myelin sheath of axons in the CNS" [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal oligodendrocytes" EXACT [] synonym: "abnormal oligoglia" EXACT [] is_a: MT:0000952 ! CNS glia morphology [Term] id: MT:0000954 name: oligodendrocyte progenitor number namespace: Trait.ontology def: "fewer cells that differentiate into a type of glial cell in the central nervous system" [J:15108] synonym: "reduced oligodendrocyte progenitor numbers" EXACT [] is_a: MT:0000953 ! oligodendrocyte morphology [Term] id: MT:0000955 name: spinal cord morphology namespace: Trait.ontology def: "malformation or disorganization of the cylindrical tissue of the vertebral canal that extends from the medulla oblongata to the conus medullaris" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] synonym: "abnormal spinal cord" EXACT [] synonym: "spinal cord abnormalities" EXACT [] is_a: MT:0003632 ! nervous system morphology [Term] id: MT:0000958 name: peripheral nervous system integrity namespace: Trait.ontology def: "a retrogressive impairment of function or destruction of the ganglia and peripheral nerves that lie outside the brain and spinal cord" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, Principles of Neural Science_3rd edition:ISBN 0-8385-8034-3] synonym: "degeneration of peripheral nervous system" EXACT [] is_a: MT:0003633 ! nervous system physiology [Term] id: MT:0000959 name: somatic sensory system morphology namespace: Trait.ontology synonym: "abnormal somatic sensory system" EXACT [] synonym: "somatic sensory system abnormalities" EXACT [] is_a: MT:0002752 ! somatic nervous system morphology [Term] id: MT:0000960 name: sensory ganglia morphology namespace: Trait.ontology def: "malformation or absence of a group of sensory neuron cell bodies" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, J:64962, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal sensory ganglia" EXACT [] synonym: "sensory ganglia abnormalities" EXACT [] is_a: MT:0000959 ! somatic sensory system morphology is_a: MT:0001104 ! spinal ganglia morphology [Term] id: MT:0000961 name: dorsal root ganglia morphology namespace: Trait.ontology def: "malformed group of nerve cell bodies of each segmental nerve projecting from the spinal cord" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, J:60159, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal dorsal root ganglia" EXACT [] synonym: "dorsal root ganglia abnormalities" EXACT [] is_a: MT:0000959 ! somatic sensory system morphology is_a: MT:0001104 ! spinal ganglia morphology [Term] id: MT:0000962 name: dorsal root ganglia organization namespace: Trait.ontology def: "loss of segmentation pattern of dorsal root ganglia; loss of regular spacing" [J:62022, J:62023] is_a: MT:0000961 ! dorsal root ganglia morphology [Term] id: MT:0000963 name: fused dorsal root ganglia namespace: Trait.ontology def: "loss of DRG spacing pattern and the appearance of two or more ganglia as one" [J:62022, J:62023] is_a: MT:0000961 ! dorsal root ganglia morphology [Term] id: MT:0000964 name: dorsal root ganglia size namespace: Trait.ontology def: "reduced size of the dorsal root ganglia" [J:17123] is_a: MT:0000961 ! dorsal root ganglia morphology [Term] id: MT:0000965 name: sensory neuron morphology namespace: Trait.ontology def: "malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of sensory impulses" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, J:60159, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal sensory neurons" EXACT [] is_a: MT:0000959 ! somatic sensory system morphology is_a: MT:0002882 ! neuron [Term] id: MT:0000967 name: sensory neuron projections namespace: Trait.ontology def: "misprojection or failure to bundle sensory axons to an effector tissue or to the spinal cord" [J:60159, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8/ CLS] is_a: MT:0000968 ! sensory neuron innervation [Term] id: MT:0000968 name: sensory neuron innervation namespace: Trait.ontology def: "defective or incomplete supply of nerve fibers to sensory termini or to spinal cord" [J:31622] is_a: MT:0000965 ! sensory neuron morphology is_a: MT:0002184 ! innervation [Term] id: MT:0000969 name: nociceptor morphology namespace: Trait.ontology def: "anomalous structure of any of the peripheral receptors for pain, including receptors sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli" [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal nociceptors" EXACT [] is_a: MT:0000965 ! sensory neuron morphology [Term] id: MT:0000970 name: polymodal receptor morphology namespace: Trait.ontology def: "anomaly in a sensory receptor that may be stimulated by mechanical, thermal or chemical means" [Principles of Neural Science_3rd edition:ISBN 0-8385-8034-3] synonym: "abnormal polymodal receptors" EXACT [] is_a: MT:0000965 ! sensory neuron morphology [Term] id: MT:0000971 name: thermoreceptor morphology namespace: Trait.ontology def: "anomalous structure of any of the cellular receptors that mediate the sense of temperature; in vertebrates, these are most often located under the skin" [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal thermal receptors" EXACT [] is_a: MT:0000965 ! sensory neuron morphology [Term] id: MT:0000972 name: mechanoreceptor morphology namespace: Trait.ontology def: "anomaly in the receptors of the body, usually nerve termini, that respond to mechanical pressure or distortion" [J:34172, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal mechanoreceptors" EXACT [] is_a: MT:0000965 ! sensory neuron morphology [Term] id: MT:0000973 name: cutaneous/subcutaneous mechanoreceptor morphology namespace: Trait.ontology def: "malformed receptors that respond to mechanical pressure or distortion in the skin" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal cutaneous/subcutaneous mechanoreceptors" EXACT [] is_a: MT:0000972 ! mechanoreceptor morphology [Term] id: MT:0000974 name: hair guard neuron morphology namespace: Trait.ontology def: "anomaly of the subcutaneous mechanoreceptors that innervate guard hairs" [J:49472] synonym: "abnormal hair guard neurons" EXACT [] is_a: MT:0000973 ! cutaneous/subcutaneous mechanoreceptor morphology [Term] id: MT:0000976 name: innervation of hair guard cells namespace: Trait.ontology def: "more robust innervation of the hair guard cells" [J:65163] is_a: MT:0000974 ! hair guard neuron morphology [Term] id: MT:0000977 name: hair-tylotrich neuron morphology namespace: Trait.ontology def: "anomaly of the subcutaneous mechanoreceptors that innervate tylotrich hair follicles" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] synonym: "abnormal hair-tylotrich neurons" EXACT [] is_a: MT:0000973 ! cutaneous/subcutaneous mechanoreceptor morphology [Term] id: MT:0000978 name: innervation of hair-tylotrich cells namespace: Trait.ontology def: "more robust innervation of the hair tylotrich cells" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0000977 ! hair-tylotrich neuron morphology [Term] id: MT:0000979 name: hair-down neuron morphology namespace: Trait.ontology def: "anomaly of the subcutaneous mechanoreceptors that innervate vellus hairs" [J:49472] synonym: "abnormal D-hair receptors" EXACT [] synonym: "abnormal hair-down neurons" EXACT [] is_a: MT:0000973 ! cutaneous/subcutaneous mechanoreceptor morphology [Term] id: MT:0000981 name: innervation of hair-down cells namespace: Trait.ontology def: "more robust innervation of the hair down cells" [J:65163] is_a: MT:0000979 ! hair-down neuron morphology [Term] id: MT:0000982 name: Meissner's corpuscle morphology namespace: Trait.ontology def: "structural anomaly of any of the numerous oval bodies found in the dermal papillae of thick skin; believed to be mechanoreceptors for tactile sensation" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal oval corpuscle" EXACT [] synonym: "abnormal touch corpuscle" EXACT [] synonym: "normal Meissner's corpuscle" EXACT [] is_a: MT:0000973 ! cutaneous/subcutaneous mechanoreceptor morphology [Term] id: MT:0000983 name: Meissner's corpuscle size namespace: Trait.ontology def: "larger than average size of the dermal mechanoreceptors for tactile sensation " [J:65163] synonym: "enlarged oval corpuscle" EXACT [] synonym: "enlarged touch corpuscle" EXACT [] is_a: MT:0000982 ! Meissner's corpuscle morphology [Term] id: MT:0000984 name: innervation of Meissner's corpuscle namespace: Trait.ontology def: "more robust supply of nerve fibers connected to any part of the numerous oval bodies found in the dermal papillae of thick skin and which are believed to be mechanoreceptors for tactile sensation" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000982 ! Meissner's corpuscle morphology [Term] id: MT:0000985 name: Merkel's receptor morphology namespace: Trait.ontology def: "structural anomaly of the modified epidermal cells located in the stratum basale and found mostly in areas where sensory perception is acute" [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal Merkel's receptor" EXACT [] is_a: MT:0000973 ! cutaneous/subcutaneous mechanoreceptor morphology [Term] id: MT:0000986 name: Merkel's receptor number namespace: Trait.ontology def: "greater than the normal number of the modified epidermal cells located in the stratum basale and found mostly in areas where sensory perception is acute" [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "increased numbers of Merkel's receptors" EXACT [] is_a: MT:0000985 ! Merkel's receptor morphology [Term] id: MT:0000987 name: innervation of Merkel's receptor namespace: Trait.ontology def: "more robust supply of nerve fibers connected to the modified epidermal cells located in the stratum basale and found mostly in areas where sensory perception is acute" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0000985 ! Merkel's receptor morphology [Term] id: MT:0000988 name: pacinian corpuscle morphology namespace: Trait.ontology def: "anomalous structure of any of the rapidly adapting mechanoreceptors found in subcutaneous tissue beneath both hairy and glabrous skin, and which normally contain an afferent nerve fiber surrounded by a capsule with multiple concentric layers" [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal pacinian corpuscle" EXACT [] is_a: MT:0000973 ! cutaneous/subcutaneous mechanoreceptor morphology [Term] id: MT:0000989 name: Ruffini's corpuscle morphology namespace: Trait.ontology def: "anomaly in the sensory cells in the subcutaneous tissue of the digits specialized to transduce mechanical stimuli " [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal Ruffini's corpuscle" EXACT [] is_a: MT:0000973 ! cutaneous/subcutaneous mechanoreceptor morphology [Term] id: MT:0000990 name: skeletal muscle mechanoreceptor morphology namespace: Trait.ontology def: "malformed receptors that respond to mechanical pressure or distortion in the skeletal muscle" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal muscle/skeletal mechanoreceptors" EXACT [] is_a: MT:0000972 ! mechanoreceptor morphology is_a: MT:0002108 ! muscle morphology [Term] id: MT:0000991 name: primary muscle spindle morphology namespace: Trait.ontology def: "anomalous structure of the sensory organ in muscle; involved in the stretch reflex and sensitive to stretch velocity" [Principles of Neural Science:ISBN 0-8385-8034-3] synonym: "abnormal muscle spindle-primary" EXACT [] is_a: MT:0004069 ! muscle spindle morphology [Term] id: MT:0000992 name: primary muscle spindle size namespace: Trait.ontology def: "area of the sensory organ in muscle; involved in the stretch reflex and is sensitive to stretch velocity" [J:23882, Principles of Neural Science_3rd edition:ISBN 0-8385-8034-3] synonym: "absent muscle spindle -primary" EXACT [] is_a: MT:0000991 ! primary muscle spindle morphology [Term] id: MT:0000994 name: secondary muscle spindle morphology namespace: Trait.ontology def: "anomalous structure of the sensory organ in muscle; involved in the stretch reflex and not sensitive to stretch velocity" [What's wrong with my mouse?:ISBN 0-471-31639-3] synonym: "abnormal muscle spindle-secondary" EXACT [] is_a: MT:0004069 ! muscle spindle morphology [Term] id: MT:0000995 name: secondary muscle spindle size namespace: Trait.ontology def: "area of the sensory organ in muscle; involved in the stretch reflex and is not sensitive to stretch velocity" [J:23882, What's wrong with my mouse?:ISBN 0-471-31639-3] synonym: "absent muscle spindle -secondary" EXACT [] is_a: MT:0000994 ! secondary muscle spindle morphology [Term] id: MT:0000997 name: joint capsule morphology namespace: Trait.ontology def: "anomalous structure of the sac that encloses the articulating ends of bones participating in a synovial joint " [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal joint capsule" EXACT [] is_a: MT:0002932 ! joint morphology [Term] id: MT:0000999 name: golgi tendon organ morphology namespace: Trait.ontology def: "anomalous structure of the sensory organ in muscle that is involved in regulating muscle tension" [Principles of Neural Science:ISBN 0-8385-8034-3] synonym: "abnormal golgi tendon organ" EXACT [] is_a: MT:0000990 ! skeletal muscle mechanoreceptor morphology [Term] id: MT:0001001 name: chemoreceptor morphology namespace: Trait.ontology def: "anomalous structure of any of the cells specialized to detect chemical substances and relay that information centrally in the nervous system" [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal chemoreceptors" EXACT [] is_a: MT:0000965 ! sensory neuron morphology [Term] id: MT:0001002 name: taste bud morphology namespace: Trait.ontology def: "anomalous structure of the small sensory organs located in the tongue that contain gustatory receptor cells, basal cells, and supporting cells" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal taste buds" EXACT [] is_a: MT:0001001 ! chemoreceptor morphology is_a: MT:0005500 ! gustatory system morphology [Term] id: MT:0001003 name: olfactory receptor morphology namespace: Trait.ontology def: "anomalous structure of the specialized proteins within the neurons of the olfactory epithelium that normally bind and detect odorants " [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal olfactory receptors" EXACT [] is_a: MT:0001001 ! chemoreceptor morphology is_a: MT:0005499 ! olfactory system morphology is_a: MT:0006092 ! olfactory neuron morphology [Term] id: MT:0001004 name: photoreceptor morphology namespace: Trait.ontology def: "structural or developmental anomaly of the receptors sensitive to light " [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "abnormal photoreceptors" EXACT [] is_a: MT:0000965 ! sensory neuron morphology is_a: MT:0003728 ! photoreceptor layer [Term] id: MT:0001005 name: rod morphology namespace: Trait.ontology def: "structural or developmental anomaly of the photoreceptors that contain rhodopsin" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal rods" EXACT [] is_a: MT:0001004 ! photoreceptor morphology [Term] id: MT:0001006 name: cone morphology namespace: Trait.ontology def: "structural or developmental anomaly of the retinal receptors that give rise to color vision" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "abnormal cones" EXACT [] is_a: MT:0001004 ! photoreceptor morphology [Term] id: MT:0001007 name: sympathetic system morphology namespace: Trait.ontology def: "malformation of the part of the autonomic nervous system that innervates smooth muscle, cardiac muscle and glands and mediates the body's response to stressful situations" [MeSH:National Library of Medicine_Medical Subject Headings, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal adrenergic system" EXACT [] synonym: "abnormal somatic sympathetic system" EXACT [] synonym: "abnormal thoracolumbar system" EXACT [] synonym: "sympathetic system abnormalities" EXACT [] is_a: MT:0002751 ! autonomic nervous system morphology [Term] id: MT:0001008 name: sympathetic ganglia morphology namespace: Trait.ontology def: "malformed or absent groups of neuronal cell bodies of the autonomic nervous system" [J:18048] synonym: "sympathetic ganglia abnormalities" EXACT [] is_a: MT:0001007 ! sympathetic system morphology is_a: MT:0001104 ! spinal ganglia morphology [Term] id: MT:0001009 name: paravertebral ganglia cell number namespace: Trait.ontology def: "increase in cell number of the group of neuronal cell bodies of the autonomic nervous system that are located at intervals along the sympathetic trunks" [J:18048] synonym: "hyperplastic paravertebral ganglia" EXACT [] is_a: MT:0001008 ! sympathetic ganglia morphology [Term] id: MT:0001010 name: prevertebral ganglia cell number namespace: Trait.ontology def: "increase in cell number of the group of neuronal cell bodies of the autonomic nervous system that are located on the superior part of the abdominal aorta " [J:18048] synonym: "hyperplastic prevertebral ganglia" EXACT [] is_a: MT:0001008 ! sympathetic ganglia morphology [Term] id: MT:0001011 name: superior cervical ganglion morphology namespace: Trait.ontology def: "malformation or absence of the group of neurons that is the largest of the sympathetic trunk; normally lies at the base of the skull and innervates the head and neck" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal superior cervical ganglion" EXACT [] is_a: MT:0001008 ! sympathetic ganglia morphology [Term] id: MT:0001013 name: superior cervical ganglion size namespace: Trait.ontology def: "increased size of the group of neurons that is the largest of the ganglia of the sympathetic trunk; normally lies at the base of the skull and innervates the head and neck" [J:17131] is_a: MT:0001011 ! superior cervical ganglion morphology [Term] id: MT:0001016 name: middle cervical ganglion morphology namespace: Trait.ontology def: "malformation or absence of the small ganglion located at the level of the cricoid cartilage of the laryngeal wall" [MeSH:National Library of Medicine_Medical Subject Headings, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal middle cervical ganglion" EXACT [] is_a: MT:0001008 ! sympathetic ganglia morphology [Term] id: MT:0001017 name: stellate ganglion morphology namespace: Trait.ontology def: "malformation or absence of the group of neurons formed by the fusion of the inferior cervical and first thoracic ganglia" [MeSH:National Library of Medicine_Medical Subject Headings, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal cervicothoracic ganglion" EXACT [] synonym: "abnormal stellate ganglion" EXACT [] is_a: MT:0001008 ! sympathetic ganglia morphology [Term] id: MT:0001018 name: cochlear OHC efferent innervation namespace: Trait.ontology def: "the form, internal structure, or number of efferent terminals, occurring as clusters, in the cochlear OHC region; normally, medial olivocochlear neurons, which are primarily found in rostral and ventral periolivary regions, project mainly to the contralateral cochlea, and terminate directly on OHCs" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0004399 ! cochlear outer hair cell morphology [Term] id: MT:0001019 name: L4 ganglion morphology namespace: Trait.ontology def: "malformation or absence of L4 ganglion" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "abnormal L4 ganglion" EXACT [] is_a: MT:0001008 ! sympathetic ganglia morphology [Term] id: MT:0001020 name: L4 ganglion size namespace: Trait.ontology def: "increased bulk size of the L4 ganglion" [J:34172] synonym: "hypertrophy of L4 ganglion" EXACT [] is_a: MT:0001019 ! L4 ganglion morphology [Term] id: MT:0001022 name: L5 ganglion morphology namespace: Trait.ontology def: "malformation or absence of the L5 ganglion" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "abnormal L5 ganglion" EXACT [] is_a: MT:0001008 ! sympathetic ganglia morphology [Term] id: MT:0001023 name: L5 ganglion size namespace: Trait.ontology def: "increased bulk size of L5 ganglion" [J:34172] synonym: "hypertrophy of L5 ganglion" EXACT [] is_a: MT:0001022 ! L5 ganglion morphology [Term] id: MT:0001025 name: sympathetic neuron morphology namespace: Trait.ontology def: "malformation or anomalous development of any of the neurons of the part of the autonomic nervous system that innervates smooth muscle, cardiac muscle and glands and mediates the body's response to stressful situations" [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal sympathetic neurons" EXACT [] synonym: "sympathetic neuron abnormalities" EXACT [] is_a: MT:0001007 ! sympathetic system morphology [Term] id: MT:0001026 name: adrenergic neuron morphology namespace: Trait.ontology def: "malformation or absence of the neurons that release catecholamines at a synapse after an impulse" [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal adrenergic neurons" EXACT [] synonym: "adrenergic neuron abnormalities" EXACT [] is_a: MT:0001025 ! sympathetic neuron morphology [Term] id: MT:0001027 name: adrenergic innervation namespace: Trait.ontology synonym: "adrenergic innervation abnormalities" EXACT [] is_a: MT:0001026 ! adrenergic neuron morphology is_a: MT:0002184 ! innervation [Term] id: MT:0001028 name: outer hair cell stereociliary bundle morphology namespace: Trait.ontology def: "form, structure or number of the typical V or W-like pattern of arrangement of mechanosensitive hair bundles located at the apical end of cochlear OHCs; each hair bundle is normally composed of ~100 nonmotile, actin-filled microvilli (stereocilia) arranged in rows of increasing height and coupled to one another by morphologically distinct links: tip links, horizontal top connectors, shaft connectors, and ankle links; most hair bundles also possess a single motile kinocilium immediately adjacent to the tallest (outermost) row of stereocilia; a fifth link type, the kinocilial link, connects the kinocilium to its neighboring stereocilia" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0000816 ! cochlear hair cell stereociliary bundle morphology is_a: MT:0004399 ! cochlear outer hair cell morphology [Term] id: MT:0001031 name: outer hair cell stereocilia number namespace: Trait.ontology def: "number of the nonmotile, actin-filled specialized microvilli (stereocilia) normally arrayed on cochlear outer hair cells" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0000893 ! cochlear hair cell stereocilia number is_a: MT:0001028 ! outer hair cell stereociliary bundle morphology [Term] id: MT:0001032 name: peptidergic neuron morphology namespace: Trait.ontology def: "malformation or absence of the nerve fibers believed to release small peptides as their neurotransmitter" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal peptidergic neurons" EXACT [] synonym: "peptidergic neuron abnormalities" EXACT [] is_a: MT:0001025 ! sympathetic neuron morphology [Term] id: MT:0001033 name: parasympathetic system morphology namespace: Trait.ontology def: "malformation of the part of the autonomic nervous system that innervates smooth muscle, cardiac muscle and glands and regulates homeostasis" [J:53284, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal cholinergic system" EXACT [] synonym: "abnormal craniosacral system" EXACT [] synonym: "abnormal somatic parasympathetic system" EXACT [] synonym: "parasympathetic system abnormalities" EXACT [] is_a: MT:0002751 ! autonomic nervous system morphology [Term] id: MT:0001034 name: parasympathetic ganglia morphology namespace: Trait.ontology def: "malformation or absence of the ganglia of the parasympathetic nervous system, including the ciliary, pterygopalatine, submandibular, and otic ganglia in the cranial region and intrinsic (terminal) ganglia associated with target organs in the thorax and abdomen" [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal parasympathetic ganglia" EXACT [] is_a: MT:0001033 ! parasympathetic system morphology [Term] id: MT:0001035 name: submandibular ganglion morphology namespace: Trait.ontology def: "malformation or absence of the ganglion associated with the lingual nerve" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal submandibular ganglion" EXACT [] is_a: MT:0001034 ! parasympathetic ganglia morphology [Term] id: MT:0001036 name: submandibular ganglion size namespace: Trait.ontology def: "reduced size of the small parasympathetic ganglion of the lingual nerve" [J:53284, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001035 ! submandibular ganglion morphology [Term] id: MT:0001037 name: parasympathetic neuron morphology namespace: Trait.ontology def: "malformed or absent neurons of the autonomic nervous system that are responsible for innervation of smooth muscle, cardiac muscle and glands" [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal parasympathetic neurons" EXACT [] is_a: MT:0001033 ! parasympathetic system morphology [Term] id: MT:0001038 name: cholinergic neuron morphology namespace: Trait.ontology alt_id: MT:0001029 def: "malformation or absence of the neurons that utilize acetylcholine as a neurotransmitter " [Principles of Neural Science_3rd edition:ISBN 0-8385-8034-3] synonym: "cholinergic neuron abnormalities" EXACT [] is_a: MT:0001025 ! sympathetic neuron morphology is_a: MT:0001037 ! parasympathetic neuron morphology is_a: MT:0002882 ! neuron [Term] id: MT:0001039 name: cholinergic innervation namespace: Trait.ontology alt_id: MT:0001030 def: "malformation or absence of the supply of nerve fibers that utilize acetylcholine as a neurotransmitter" [Principles of Neural Science_3rd edition:ISBN 0-8385-8034-3] synonym: "cholinergic innervation abnormalities" EXACT [] is_a: MT:0001038 ! cholinergic neuron morphology is_a: MT:0002184 ! innervation [Term] id: MT:0001041 name: lacrimal gland cholinergic innervation namespace: Trait.ontology def: "supply of nerve fibers to the gland that secretes tears" [J:53284, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001039 ! cholinergic innervation [Term] id: MT:0001042 name: sublingual salivary gland cholinergic innervation namespace: Trait.ontology def: "supply of nerve fibers to the exocrine gland on the floor of the mouth that secretes saliva" [J:53284, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001039 ! cholinergic innervation [Term] id: MT:0001043 name: parotid salivary gland cholinergic innervation namespace: Trait.ontology def: "supply of nerve fibers to the exocrine gland lateral to the jaw that secretes saliva" [J:53284, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001039 ! cholinergic innervation [Term] id: MT:0001044 name: enteric nervous system morphology namespace: Trait.ontology def: "malformation or absence of the part of the autonomic nervous system that innervates the esophagus, stomach, small and large bowel" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] synonym: "abnormal enteric nervous system" EXACT [] synonym: "enteric nervous system abnormalities" EXACT [] is_a: MT:0002751 ! autonomic nervous system morphology [Term] id: MT:0001045 name: enteric ganglia morphology namespace: Trait.ontology def: "any structural anomaly or deformity of the groups of nerve cell bodies associated with the enteric neurons" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] synonym: "abnormal enteric ganglia" EXACT [] is_a: MT:0001044 ! enteric nervous system morphology [Term] id: MT:0001046 name: enteric neuron morphology namespace: Trait.ontology def: "malformed or absent neurons that innervate the esophagus, stomach, small and large bowel" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] synonym: "abnormal enteric neurons" EXACT [] is_a: MT:0001044 ! enteric nervous system morphology [Term] id: MT:0001047 name: enteric cholinergic neuron morphology namespace: Trait.ontology def: "malformation or absence of the neurons that utilize acetylcholine as a neurotransmitter and innervate the esophagus, stomach, small and large bowel" [Principles of Neural Science_3rd edition:ISBN 0-8385-8034-3] synonym: "abnormal enteric cholinergic neurons" EXACT [] is_a: MT:0001046 ! enteric neuron morphology [Term] id: MT:0001048 name: enteric neuron number namespace: Trait.ontology def: "missing neurons that innervate the esophagus, stomach, small and large bowel" [J:49471, Principles of Neural Science:ISBN 0-8385-8034-3] synonym: "absence of enteric neurons" EXACT [] is_a: MT:0001046 ! enteric neuron morphology [Term] id: MT:0001049 name: enteric cholinergic innervation namespace: Trait.ontology def: "malformation or absence of the supply of nerve fibers that utilize acetylcholine as a neurotransmitter to the intestinal system" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001039 ! cholinergic innervation is_a: MT:0001047 ! enteric cholinergic neuron morphology [Term] id: MT:0001051 name: somatic motor system morphology namespace: Trait.ontology synonym: "abnormal somatic motor system" EXACT [] synonym: "somatic motor system abnormalities" EXACT [] is_a: MT:0002752 ! somatic nervous system morphology [Term] id: MT:0001052 name: muscle innervation namespace: Trait.ontology def: "malformation or misprojection of sensory or motor nerves to targets in muscle" [J:75958] synonym: "muscle innervation abnormalities" EXACT [] is_a: MT:0001051 ! somatic motor system morphology is_a: MT:0002184 ! innervation [Term] id: MT:0001053 name: neuromuscular synapse morphology namespace: Trait.ontology def: "malformed or absent membrane to membrane contact of a motor axon and a muscle myofiber resulting in aberrant transmission of nerve impulses" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, J:47439, J:60159, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal neuromuscular junction" EXACT [] synonym: "neuromuscular synapse abnormalities" EXACT [] is_a: MT:0001051 ! somatic motor system morphology is_a: MT:0002184 ! innervation [Term] id: MT:0001054 name: presynaptic differentiation namespace: Trait.ontology def: "inability of nerve terminals to find target and/or form terminal arbors for synaptic transmission" [J:61509] is_a: MT:0001053 ! neuromuscular synapse morphology [Term] id: MT:0001055 name: postsynaptic differentiation namespace: Trait.ontology def: "inability of an effector cell to form a differentiated postsynaptic membrane in response to innervation" [J:61509] is_a: MT:0001053 ! neuromuscular synapse morphology [Term] id: MT:0001056 name: cranial nerve morphology namespace: Trait.ontology def: "any anomaly, deformity, or malformation of any of the twelve nerves that emerge from the cranium as opposed to the spinal nerves" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, J:45302, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal cranial nerves" EXACT [] synonym: "cranial nerve abnormalities" EXACT [] is_a: MT:0002752 ! somatic nervous system morphology [Term] id: MT:0001059 name: optic nerve size namespace: Trait.ontology alt_id: MT:0001331 def: "wasting of the second cranial nerve which is responsible for conveying visual information from the retina to the brain" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] synonym: "atrophic optic nerve" EXACT [] synonym: "atrophy of optic nerve" EXACT [] is_a: MT:0001330 ! optic nerve morphology [Term] id: MT:0001061 name: oculomotor nerve morphology namespace: Trait.ontology def: "malformation or misprojection of the 3rd cranial nerve, which normally sends motor fibers to the levator muscles of the eyelid and to the superior rectus, inferior rectus, and inferior oblique muscles of the eye; and also sends parasympathetic efferents to the muscles controlling pupillary constriction and accommodation" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal oculomotor nerve" EXACT [] synonym: "CN-III" EXACT [] synonym: "oculomotor nerve abnormalities" EXACT [] is_a: MT:0001056 ! cranial nerve morphology [Term] id: MT:0001062 name: oculomotor nerve size namespace: Trait.ontology def: "volume, width or length of the nerve of the extraocular muscles, iris and ciliary body" [J:19212, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001061 ! oculomotor nerve morphology [Term] id: MT:0001063 name: trochlear nerve morphology namespace: Trait.ontology def: "any malformation or misprojection of the 4th cranial nerve, which normally carries the motor innervation of the superior oblique muscles of the eye " [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal trochlear nerve" EXACT [] synonym: "CN-IV" EXACT [] synonym: "trochlear nerve abnormalities" EXACT [] is_a: MT:0001056 ! cranial nerve morphology [Term] id: MT:0001064 name: trochlear nerve size namespace: Trait.ontology def: "length, width, or area of the nerve of the superior oblique muscle" [J:19212, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "absence of trochlear nerve" EXACT [] is_a: MT:0001063 ! trochlear nerve morphology [Term] id: MT:0001065 name: trigeminal nerve morphology namespace: Trait.ontology def: "malformed chief sensory nerve of the face and motor nerve of the muscles of mastication; has three major divisions: ophthalmic, maxillary and mandibular " [J:33038, Principles of Neural Science:ISBN 0-8385-8034-3, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal trigeminal nerve" EXACT [] synonym: "CN-V" EXACT [] synonym: "trigeminal nerve abnormalities" EXACT [] is_a: MT:0001056 ! cranial nerve morphology [Term] id: MT:0001067 name: mandibular nerve morphology namespace: Trait.ontology def: "form or structure of the third division of the trigeminal nerve " [J:33038, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "absence of mandibular nerve" EXACT [] is_a: MT:0001065 ! trigeminal nerve morphology [Term] id: MT:0001068 name: mandibular nerve branching morphology namespace: Trait.ontology def: "malformed or misprojected axons of the mandibular nerve" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, J:60159, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal branching of mandibular nerve" EXACT [] is_a: MT:0001067 ! mandibular nerve morphology [Term] id: MT:0001069 name: trigeminal nerve connections to hindbrain morphology namespace: Trait.ontology def: "structure of the axonal connections from the trigeminal ganglion to the pons and medulla oblongata" [J:33038] synonym: "absence of trigeminal nerve connections to hindbrain" EXACT [] is_a: MT:0001065 ! trigeminal nerve morphology [Term] id: MT:0001070 name: abducens nerve morphology namespace: Trait.ontology def: "any anomaly, deformity, or malformation of the 6th cranial nerve, which originates in the abducens nucleus of the pons and sends motor fibers to the lateral rectus muscles of the eye" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abducens nerve abnormalities" EXACT [] synonym: "CN-VI" EXACT [] is_a: MT:0001056 ! cranial nerve morphology [Term] id: MT:0001071 name: facial nerve morphology namespace: Trait.ontology def: "malformed or misprojection of motor axons from the pons to the face" [J:29973, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal facial nerve" EXACT [] synonym: "CN-VII" EXACT [] synonym: "facial nerve abnormalities" EXACT [] is_a: MT:0001056 ! cranial nerve morphology [Term] id: MT:0001072 name: vestibulocochlear nerve morphology namespace: Trait.ontology def: "malformed sensory nerve innervating the receptor cells of the membranous labyrinth" [J:23837, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal vestibulocochlear nerve" EXACT [] synonym: "CN-VIII" EXACT [] synonym: "vestibulocochlear nerve abnormalities" EXACT [] is_a: MT:0001056 ! cranial nerve morphology [Term] id: MT:0001073 name: glossopharyngeal nerve morphology namespace: Trait.ontology def: "malformed or misprojection of sensory and autonomic axons to the parotid gland, carotid body, posterior third of the tongue" [J:33038, Principles of Neural Science:ISBN 0-8385-8034-3] synonym: "abnormal glossopharyngeal nerve" EXACT [] synonym: "CN-IX" EXACT [] synonym: "glossopharyngeal nerve abnormalities" EXACT [] is_a: MT:0001056 ! cranial nerve morphology [Term] id: MT:0001074 name: vagus nerve morphology namespace: Trait.ontology def: "malformed or misprojection of autonomic, sensory and motor axons of the tenth cranial nerve to the pharynx, larynx, trachea, lungs, heart and GI tract" [J:33038, Principles of Neural Science:ISBN 0-8385-8034-3] synonym: "abnormal vagus nerve" EXACT [] synonym: "CN-X" EXACT [] synonym: "vagus nerve abnormalities" EXACT [] is_a: MT:0001056 ! cranial nerve morphology [Term] id: MT:0001075 name: accessory nerve morphology namespace: Trait.ontology def: "any malformation or misprojection of the 11th cranial nerve, which normally originates from neurons in the medulla and in the cervical spinal cord" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal spinal accessory nerve" EXACT [] synonym: "abnormal spinal accessory nerve morphology" EXACT [] synonym: "CN-XI" EXACT [] synonym: "spinal accessory nerve abnormalities" EXACT [] is_a: MT:0001056 ! cranial nerve morphology [Term] id: MT:0001076 name: hypoglossal nerve morphology namespace: Trait.ontology def: "malformation or misprojection of motor axons to the tongue" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, J:45302, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal hypoglossal nerve" EXACT [] synonym: "CN-XII" EXACT [] synonym: "hypoglossal nerve abnormalities" EXACT [] is_a: MT:0001056 ! cranial nerve morphology [Term] id: MT:0001077 name: spinal nerve morphology namespace: Trait.ontology def: "any anomaly, deformity, or malformation of the any of the 31 paired peripheral nerves formed by the union of the dorsal and ventral spinal roots from each spinal cord segment" [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal spinal nerves" EXACT [] synonym: "spinal nerve abnormalities" EXACT [] is_a: MT:0002752 ! somatic nervous system morphology [Term] id: MT:0001078 name: phrenic nerve morphology namespace: Trait.ontology def: "malformed or misprojection of motor and sensory neuron axons to the diaphragm and other tissues" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, J:60159, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001077 ! spinal nerve morphology [Term] id: MT:0001080 name: defasiculated phrenic nerve namespace: Trait.ontology def: "misprojection or failure to bundle motor and sensory neuron axons to the diaphragm and other tissues" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001078 ! phrenic nerve morphology [Term] id: MT:0001081 name: cranial ganglia morphology namespace: Trait.ontology def: "any anomaly, deformity, or malformation of the groups of nerve cell bodies associated with the twelve cranial nerves" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, J:45302, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal cranial ganglia" EXACT [] synonym: "cranial ganglia abnormalities" EXACT [] is_a: MT:0002752 ! somatic nervous system morphology [Term] id: MT:0001082 name: geniculate ganglion morphology namespace: Trait.ontology def: "malformed group of sensory neuron cell bodies associated with the facial nerve (seventh cranial nerve)" [J:45302, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal geniculate ganglion of facial (VII) nerve" EXACT [] synonym: "cranial ganglion VII" EXACT [] is_a: MT:0001081 ! cranial ganglia morphology [Term] id: MT:0001083 name: geniculate ganglion size namespace: Trait.ontology def: "reduced size of the geniculate ganglion or decreased size of sensory neuron cell bodies associated with the facial nerve" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001082 ! geniculate ganglion morphology [Term] id: MT:0001084 name: petrosal ganglion morphology namespace: Trait.ontology alt_id: MT:0001099 def: "malformation of the lower group of sensory neuron cell bodies associated with the glossopharyngeal nerve" [J:45302, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal extracraniale ganglion morphology" EXACT [] synonym: "abnormal inferior glossopharyngeal ganglion" EXACT [] synonym: "abnormal inferior glossopharyngeal ganglion of the glossopharyngeal (IX) nerve" EXACT [] synonym: "abnormal petrosal ganglion" EXACT [] is_a: MT:0001096 ! glossopharyngeal ganglion morphology [Term] id: MT:0001085 name: petrosal ganglion size namespace: Trait.ontology def: "reduced size of the petrosal ganglion" [J:25565] is_a: MT:0001084 ! petrosal ganglion morphology [Term] id: MT:0001087 name: nodose ganglion morphology namespace: Trait.ontology alt_id: MT:0001103 def: "malformation of the large group of sensory neuron cell bodies, anterior to the jugular vein, associated with the vagus nerve (tenth cranial nerve)" [J:45302, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal inferior vagus ganglion" EXACT [] synonym: "abnormal inferior vagus ganglion of the vagus (X) nerve" EXACT [] synonym: "abnormal nodose ganglion" EXACT [] synonym: "cranial ganglion X" EXACT [] is_a: MT:0001100 ! vagus ganglion morphology [Term] id: MT:0001088 name: nodose ganglion size namespace: Trait.ontology def: "reduced size of the nodose ganglion" [J:17123, J:25565] is_a: MT:0001087 ! nodose ganglion morphology [Term] id: MT:0001089 name: nodose ganglion neuron number namespace: Trait.ontology def: "count of the sensory neurons comprising the nodose ganglion" [J:45302, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001087 ! nodose ganglion morphology [Term] id: MT:0001091 name: outer hair cell stereocilia size namespace: Trait.ontology def: "length, width, or volume of the nonmotile, actin-filled specialized microvilli (stereocilia) which are normally arrayed on cochlear outer hair cells" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0000894 ! cochlear hair cell stereocilia size is_a: MT:0001028 ! outer hair cell stereociliary bundle morphology [Term] id: MT:0001092 name: trigeminal ganglion morphology namespace: Trait.ontology def: "malformed group of sensory neuron cell bodies associated with the trigeminal nerve (fifth cranial nerve)" [J:33038, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal Gasserian ganglion" EXACT [] synonym: "abnormal semilunar ganglion" EXACT [] synonym: "abnormal trigeminal ganglion of trigenmial (V) nerve" EXACT [] synonym: "cranial ganglion V" EXACT [] is_a: MT:0001081 ! cranial ganglia morphology [Term] id: MT:0001094 name: trigeminal ganglion cell size namespace: Trait.ontology def: "increased bulk size of trigeminal ganglion" [J:34172] synonym: "hypertrophy of trigeminal ganglion" EXACT [] is_a: MT:0001092 ! trigeminal ganglion morphology [Term] id: MT:0001095 name: trigeminal ganglion size namespace: Trait.ontology def: "increased size of the group of sensory neuron cell bodies associated with the trigeminal nerve" [J:17131] is_a: MT:0001092 ! trigeminal ganglion morphology [Term] id: MT:0001096 name: glossopharyngeal ganglion morphology namespace: Trait.ontology def: "malformed group of neuron cell bodies associated with the ninth cranial nerve" [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal glossopharyngeal ganglia" EXACT [] synonym: "abnormal glossopharyngeal ganglia morphology" EXACT [] synonym: "cranial ganglion XI" EXACT [] is_a: MT:0001081 ! cranial ganglia morphology [Term] id: MT:0001097 name: superior glossopharyngeal ganglion morphology namespace: Trait.ontology def: "malformation of the upper ganglion of the glossopharyngeal nerve located at the jugular foramen" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal intracranial ganglion" EXACT [] synonym: "abnormal jugular ganglion" EXACT [] synonym: "abnormal superior glossopharyngeal ganglion of the glossopharyngeal (IX) nerve" EXACT [] is_a: MT:0001096 ! glossopharyngeal ganglion morphology [Term] id: MT:0001098 name: superior glossopharyngeal ganglion size namespace: Trait.ontology def: "reduced size of the upper ganglion of the glossopharyngeal nerve located at the jugular foramen" [J:18984, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001097 ! superior glossopharyngeal ganglion morphology [Term] id: MT:0001100 name: vagus ganglion morphology namespace: Trait.ontology def: "malformed group of sensory neuron cell bodies associated with the vagus nerve" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal vagus ganglia" EXACT [] synonym: "cranial ganglion X" EXACT [] is_a: MT:0001081 ! cranial ganglia morphology [Term] id: MT:0001101 name: superior vagus ganglion morphology namespace: Trait.ontology def: "malformation of the upper ganglion of the vagus nerve located at the jugular foramen" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal jugular ganglion" EXACT [] synonym: "abnormal superior vagus ganglion of the vagus (X) nerve" EXACT [] is_a: MT:0001100 ! vagus ganglion morphology [Term] id: MT:0001102 name: superior vagus ganglion size namespace: Trait.ontology def: "reduced size of the upper ganglion of the vagus nerve located at the jugular foramen" [J:18984, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001101 ! superior vagus ganglion morphology [Term] id: MT:0001104 name: spinal ganglia morphology namespace: Trait.ontology def: "any anomaly, deformity, or malformation of the groups of sensory nerve cell bodies located on the dorsal spinal roots within the vertebral column " [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal spinal ganglia" EXACT [] synonym: "spinal ganglia abnormalities" EXACT [] is_a: MT:0002752 ! somatic nervous system morphology [Term] id: MT:0001105 name: PNS glia morphology namespace: Trait.ontology def: "malformation or absence of non-neuronal cells that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons" [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal neuroglia" EXACT [] synonym: "PNS glia abnormalities" EXACT [] is_a: MT:0003634 ! glia morphology [Term] id: MT:0001106 name: Schwann cell morphology namespace: Trait.ontology def: "malformed or absent cells which form the insulating myelin sheaths of peripheral axons" [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal Schwann cells" EXACT [] synonym: "Schwann cell abnormalities" EXACT [] is_a: MT:0001105 ! PNS glia morphology [Term] id: MT:0001107 name: Schwann cell number namespace: Trait.ontology def: "fewer than normal cells that sheath the axons of the peripheral nervous system" [J:29971] is_a: MT:0001106 ! Schwann cell morphology [Term] id: MT:0001116 name: gonad size namespace: Trait.ontology def: "reduced size of the testis or the ovary" [J:34193, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] subset: slim_pig synonym: "hypogonad" EXACT [] synonym: "hypogonadism" EXACT [] is_a: MT:0002211 ! primary sex determination [Term] id: MT:0001119 name: female reproductive anatomy namespace: Trait.ontology def: "anomalous structure of the organs associated with producing offspring in the gender that bears the offspring" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] subset: slim_cattle subset: slim_pig is_a: MT:0002160 ! reproductive system morphology [Term] id: MT:0001120 name: uterus morphology namespace: Trait.ontology def: "malformation or absence of the female muscular organ of gestation" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] subset: slim_pig is_a: MT:0001119 ! female reproductive anatomy [Term] id: MT:0001125 name: oocytes morphology namespace: Trait.ontology def: "anomalous structure of immature ova" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001931 ! oogenesis [Term] id: MT:0001126 name: ovary morphology namespace: Trait.ontology def: "malformed female reproductive gland containing the germ cells" [J:35782, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] subset: slim_pig synonym: "abnormal gonad" EXACT [] synonym: "abnormal ovaries" EXACT [] is_a: MT:0000653 ! sex gland morphology is_a: MT:0001119 ! female reproductive anatomy [Term] id: MT:0001127 name: ovary size namespace: Trait.ontology def: "reduced size of the female reproductive gland containing the germ cells" [J:35782, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] subset: slim_pig synonym: "small ovaries" EXACT [] is_a: MT:0001116 ! gonad size is_a: MT:0001126 ! ovary morphology [Term] id: MT:0001130 name: ovarian folliculogenesis namespace: Trait.ontology def: "atypical formation or failure to form the spherical ovum in the ovary" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, J:35782, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001131 ! ovarian follicle morphology [Term] id: MT:0001131 name: ovarian follicle morphology namespace: Trait.ontology def: "malformed or absent sac-like structure in the ovary which surrounds an ovum" [J:33042, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001126 ! ovary morphology [Term] id: MT:0001133 name: luteal cell differentiation namespace: Trait.ontology def: "abnormal development of the cells of the corpus luteum of the ovary" [J:33401, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002679 ! corpora lutea morphology [Term] id: MT:0001135 name: cervix morphology namespace: Trait.ontology def: "malformation or malfunctioning of the lower opening of the uterus to the vagina" [tc:Teresa Chu_Mouse Genome Informatics Curator] is_a: MT:0001119 ! female reproductive anatomy [Term] id: MT:0001137 name: cervical epithelium morphology namespace: Trait.ontology def: "malformation of the epithelial layer of the cervix" [tc:Teresa Chu_Mouse Genome Informatics Curator] is_a: MT:0001135 ! cervix morphology [Term] id: MT:0001138 name: cervical squamous epithelium morphology namespace: Trait.ontology def: "malformation of the scaly epithelial layer of the cervix" [J:54637, tc:Teresa Chu_Mouse Genome Informatics Curator] is_a: MT:0001137 ! cervical epithelium morphology [Term] id: MT:0001139 name: vagina morphology namespace: Trait.ontology def: "malformation of the female reproductive canal located between the uterus and the vulva" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001119 ! female reproductive anatomy [Term] id: MT:0001140 name: vaginal epithelium namespace: Trait.ontology def: "malformation of the epithelial layer of the vagina" [J:54637, tc:Teresa Chu_Mouse Genome Informatics Curator] is_a: MT:0001139 ! vagina morphology [Term] id: MT:0001141 name: thickened vaginal epithelium namespace: Trait.ontology def: "increased depth of the vaginal epithelial layer" [J:65045] is_a: MT:0001140 ! vaginal epithelium [Term] id: MT:0001142 name: vaginal opening namespace: Trait.ontology def: "a malformed or absent opening to the genital canal" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001139 ! vagina morphology [Term] id: MT:0001143 name: vaginal opening size namespace: Trait.ontology def: "shrunken, narrowed external vaginal opening" [J:50844] is_a: MT:0001142 ! vaginal opening [Term] id: MT:0001144 name: fused vaginal opening namespace: Trait.ontology def: "condition in which the external vaginal opening is closed by the adherence of the epithelium of the vagina" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0001142 ! vaginal opening [Term] id: MT:0001145 name: male reproductive anatomy namespace: Trait.ontology def: "anomalous structure of the organs associated with producing offspring in the gender that produces spermatozoa" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] subset: slim_cattle subset: slim_pig is_a: MT:0002160 ! reproductive system morphology [Term] id: MT:0001146 name: testis morphology namespace: Trait.ontology def: "anomalous structure of the male reproductive glands" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] subset: slim_cattle subset: slim_pig synonym: "abnormal gonad" EXACT [] synonym: "abnormal testes" EXACT [] is_a: MT:0000653 ! sex gland morphology is_a: MT:0001145 ! male reproductive anatomy [Term] id: MT:0001148 name: testes size namespace: Trait.ontology def: "increased size of the male reproductive glands" [J:63229, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] subset: slim_cattle subset: slim_pig synonym: "enlarged testis" EXACT [] synonym: "macroorchidism" EXACT [] is_a: MT:0001116 ! gonad size is_a: MT:0001146 ! testis morphology [Term] id: MT:0001150 name: scrotum size namespace: Trait.ontology def: "increased size of the external sac of skin that encloses the testes" [J:65045, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002669 ! scrotum morphology [Term] id: MT:0001151 name: foreskin size namespace: Trait.ontology def: "increased size of the loose fold of skin that covers the penis" [J:65045] is_a: MT:0003553 ! foreskin morphology [Term] id: MT:0001153 name: seminiferous tubule size namespace: Trait.ontology def: "reduced diameter of the tubules in the testes where spermatogenesis occurs" [J:50844] synonym: "narrow seminiferous tubules" EXACT [] is_a: MT:0002216 ! seminiferous tubule morphology [Term] id: MT:0001154 name: seminiferous tubule integrity namespace: Trait.ontology def: "a retrogressive impairment of function or destruction of the tubules in the testes where spermatogenesis occurs" [J:50844] synonym: "degeneration of seminiferous tubules" EXACT [] is_a: MT:0002216 ! seminiferous tubule morphology [Term] id: MT:0001156 name: spermatogenesis namespace: Trait.ontology def: "incomplete maturation or aberrant formation of the male gametes" [J:58959] subset: slim_pig synonym: "abnormal sperm development" EXACT [] is_a: MT:0001929 ! gametogenesis [Term] id: MT:0001158 name: prostate morphology namespace: Trait.ontology alt_id: MT:0000658 def: "malformed gland in males that secretes part of the seminiferous fluid" [J:63764, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000653 ! sex gland morphology is_a: MT:0001145 ! male reproductive anatomy [Term] id: MT:0001163 name: coagulating gland morphology namespace: Trait.ontology alt_id: MT:0000663 def: "malformed or malfunctioning anterior lobe of the prostate" [J:64981] synonym: "abnormal anterior prostate" EXACT [] is_a: MT:0001158 ! prostate morphology [Term] id: MT:0001168 name: prostate epithelial cell morphology namespace: Trait.ontology alt_id: MT:0000668 def: "abnormal development of the prostate epithelium" [J:63764] is_a: MT:0001158 ! prostate morphology [Term] id: MT:0001169 name: bulbourethral gland morphology namespace: Trait.ontology alt_id: MT:0000669 def: "malformed gland in males that lies along the prostate gland and secretes a fluid component of the seminal fluid into the urethra " [J:54465, J:63764, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal Cowper's gland" EXACT [] is_a: MT:0000653 ! sex gland morphology is_a: MT:0001145 ! male reproductive anatomy [Term] id: MT:0001170 name: bulbourethral gland size namespace: Trait.ontology alt_id: MT:0000670 def: "increased cell number in the bulbourethral gland" [J:63764, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "Cowper's gland hyperplasia" EXACT [] synonym: "hyperplastic bulbourethral gland" EXACT [] synonym: "hyperplastic Cowper's gland" EXACT [] is_a: MT:0001169 ! bulbourethral gland morphology [Term] id: MT:0001173 name: number of ductal cells of the bulbourethral gland namespace: Trait.ontology alt_id: MT:0000673 def: "fewer than the normal number of cells found in the ducts through which the bulbourethral glands discharge mucus into the spongy part of the urethra" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "reduced number of ductal cells in the Cowper's gland" EXACT [] is_a: MT:0001169 ! bulbourethral gland morphology [Term] id: MT:0001175 name: lung morphology namespace: Trait.ontology def: "malformed organ of respiration" [J:35802] subset: slim_chkn synonym: "abnormal lung" EXACT [] is_a: MT:0002132 ! respiratory system morphology [Term] id: MT:0001176 name: lung development namespace: Trait.ontology def: "malformation or arrest of differentiation of the organs of respiration" [J:54931, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0003115 ! respiratory system development [Term] id: MT:0001177 name: atelectasis namespace: Trait.ontology def: "collapse of the lung or any portion of the lung, or decreased or absent air in the lung, resulting in loss of lung volume" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, J:54931, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002133 ! respiratory system physiology [Term] id: MT:0001178 name: lung cell number namespace: Trait.ontology def: "reduced size of the respiratory organ due to reduced cell number in all or part of the organ" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Pathology_2nd edition:ISBN 0-397-51047-0] synonym: "hypoplastic lung" EXACT [] is_a: MT:0003641 ! lung size [Term] id: MT:0001179 name: alveolar septum thickness namespace: Trait.ontology def: "increased width of the structure that separates the air sacs (alveoli) in the lung" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] synonym: "thick alveolar septa" EXACT [] is_a: MT:0002270 ! respiratory alveoli morphology [Term] id: MT:0001180 name: inner hair cell stereociliary bundle morphology namespace: Trait.ontology def: "form, internal structure, or number of the typically linear or U-shaped pattern of arrangement of mechanosensitive hair bundles located at the apical end of cochlear IHCs; each hair bundle is normally composed of ~100 nonmotile, actin-filled microvilli (stereocilia) arranged in rows of increasing height and coupled to one another by morphologically distinct links: tip links, horizontal top connectors, shaft connectors, and ankle links; most hair bundles also possess a single motile kinocilium immediately adjacent to the tallest row of stereocilia; a fifth link type, the kinocilial link, connects the kinocilium to its neighboring stereocilia" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0000816 ! cochlear hair cell stereociliary bundle morphology is_a: MT:0004393 ! cochlear inner hair cell morphology [Term] id: MT:0001183 name: respiratory alveoli size namespace: Trait.ontology def: "expanded volume of the saclike terminal dilation of the respiratory bronchioles" [J:66345] synonym: "dilated alveoli" EXACT [] synonym: "enlarged alveoli" EXACT [] is_a: MT:0002270 ! respiratory alveoli morphology [Term] id: MT:0001186 name: pigmentation trait namespace: Trait.ontology subset: slim_cattle subset: slim_pig is_a: MT:0000001 ! Trait [Term] id: MT:0001188 name: pigment content namespace: Trait.ontology def: "excess of pigment in any or all tissues or a part of a tissue" [J:50311, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001186 ! pigmentation trait [Term] id: MT:0001189 name: skin pigmentation level namespace: Trait.ontology def: "concentration of pigmentation of the skin" [J:53370] synonym: "albino" EXACT [] synonym: "pale skin" EXACT [] is_a: MT:0002095 ! skin pigmentation [Term] id: MT:0001190 name: reddish skin namespace: Trait.ontology def: "skin has a more intense ruddy appearance than normal, often due to capillary congestion" [J:65038] synonym: "erythematous skin" EXACT [] is_a: MT:0002095 ! skin pigmentation [Term] id: MT:0001191 name: skin condition namespace: Trait.ontology def: "anomalous state of the skin" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] subset: slim_pig is_a: MT:0002096 ! skin condition/ morphology [Term] id: MT:0001192 name: scaly skin namespace: Trait.ontology def: "skin covered with shedding scales or flakes" [J:65146] is_a: MT:0001191 ! skin condition [Term] id: MT:0001193 name: psoriasis namespace: Trait.ontology def: "chronic skin lesions characterized by inflammation and silvery-scaly patches" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001191 ! skin condition [Term] id: MT:0001194 name: dermatitis namespace: Trait.ontology alt_id: MT:0001205 alt_id: MT:0001206 def: "inflammation of the skin" [J:65146] synonym: "inflamed skin" EXACT [] synonym: "irritated skin" EXACT [] is_a: MT:0001846 ! tissue specific inflammatory response [Term] id: MT:0001195 name: flaky skin namespace: Trait.ontology def: "shedding scales on the skin " [J:56641] is_a: MT:0001191 ! skin condition [Term] id: MT:0001196 name: shiny skin namespace: Trait.ontology def: "skin with a glossy or glistening appearance" [J:56641] is_a: MT:0001191 ! skin condition [Term] id: MT:0001197 name: oily skin namespace: Trait.ontology def: "skin secreting an unusually high amount of oil, resulting in a glossy, shiny appearance" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0001196 ! shiny skin [Term] id: MT:0001198 name: tight skin namespace: Trait.ontology def: "skin has a taut, stretched appearance" [J:65038] synonym: "taut skin" EXACT [] is_a: MT:0001191 ! skin condition [Term] id: MT:0001200 name: skin thickness namespace: Trait.ontology def: "greater depth of skin" [J:47225] subset: slim_pig is_a: MT:0001191 ! skin condition [Term] id: MT:0001201 name: translucent skin namespace: Trait.ontology def: "skin that is transparent to light " [J:15108] is_a: MT:0001191 ! skin condition [Term] id: MT:0001202 name: skin photosensitivity namespace: Trait.ontology def: "abnormally heightened reactivity of the skin to sunlight " [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001191 ! skin condition is_a: MT:0005501 ! skin physiology [Term] id: MT:0001204 name: skin irradiation susceptibility namespace: Trait.ontology def: "incidence of aberrant or damaged cells due to a given amount of irradiation induced genotoxic damage" [J:65162] is_a: MT:0001191 ! skin condition is_a: MT:0005501 ! skin physiology [Term] id: MT:0001208 name: blistering namespace: Trait.ontology def: "accumulation of fluid- filled thin walled structures under the epidermis or within the epidermis" [J:65039] is_a: MT:0001191 ! skin condition [Term] id: MT:0001209 name: spontaneous skin ulceration namespace: Trait.ontology def: "unpredictable appearance of skin lesions, usually with inflammation" [J:65302] synonym: "skin ulceration" EXACT [] is_a: MT:0001191 ! skin condition [Term] id: MT:0001210 name: thick skin ridges namespace: Trait.ontology def: "long raised strips of skin, usually aligned to the proximal-distal axis" [J:51296] is_a: MT:0001191 ! skin condition [Term] id: MT:0001211 name: wrinkled skin namespace: Trait.ontology def: "irregular folds and/or indentations on the skin" [J:19212] is_a: MT:0001191 ! skin condition [Term] id: MT:0001212 name: skin lesions namespace: Trait.ontology def: "focal patches of inflammation on the skin" [J:30162] is_a: MT:0001191 ! skin condition [Term] id: MT:0001213 name: skin cell number namespace: Trait.ontology def: "greater than or fewer than the expected numbers of cells in the cutis" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] is_a: MT:0002060 ! skin morphology [Term] id: MT:0001216 name: epidermal layer morphology namespace: Trait.ontology def: "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal epidermal layer" EXACT [] synonym: "abnormal epidermis" EXACT [] is_a: MT:0002060 ! skin morphology [Term] id: MT:0001219 name: epidermal layer thickness namespace: Trait.ontology def: "increase in the width of the epidermal cell layer in the skin" [J:65146] is_a: MT:0001216 ! epidermal layer morphology [Term] id: MT:0001220 name: level of epidermal layer cell death namespace: Trait.ontology def: "pathological cell death in the epidermal layer of the skin, usually due to irreversible damage" [J:65146] synonym: "necrotic epidermis" EXACT [] is_a: MT:0001216 ! epidermal layer morphology [Term] id: MT:0001221 name: epidermal layer integrity namespace: Trait.ontology def: "wasting of the epidermal layer of the skin" [J:65033] is_a: MT:0001216 ! epidermal layer morphology [Term] id: MT:0001222 name: epidermal layer cell number namespace: Trait.ontology def: "increase in size of the epidermis due to increase in epidermal cell number" [J:65146, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001216 ! epidermal layer morphology [Term] id: MT:0001224 name: keratinocyte apoptosis namespace: Trait.ontology def: "aberrant programmed cell death of keratin producing cells of the epidermis" [J:64948] xref: GO:0006915 xref: GO:0030216 is_a: MT:0002655 ! keratinocyte morphology [Term] id: MT:0001225 name: epidermal layer development namespace: Trait.ontology def: "abnormal development of the epidermis" [J:62478] is_a: MT:0001216 ! epidermal layer morphology is_a: MT:0003941 ! skin development [Term] id: MT:0001230 name: epidermal desquamation namespace: Trait.ontology def: "shedding of the cuticle of the epidermis in scales or shreds" [J:56777, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001216 ! epidermal layer morphology [Term] id: MT:0001231 name: basal cell layer morphology namespace: Trait.ontology def: "structural anomaly of the deepest layer of the epidermis, which is composed of dividing stem cells and anchoring cells" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal basal cell layer" EXACT [] synonym: "abnormal basal layer" EXACT [] synonym: "abnormal columnar layer" EXACT [] synonym: "abnormal germinative layer" EXACT [] synonym: "abnormal palisade layer" EXACT [] synonym: "abnormal stratum basale epidermis" EXACT [] synonym: "abnormal stratum cylindricum" EXACT [] synonym: "abnormal stratum germinativum" EXACT [] is_a: MT:0001216 ! epidermal layer morphology [Term] id: MT:0001233 name: suprabasal layer morphology namespace: Trait.ontology def: "malformed or atypical condition of the suprabasal layer of the skin" [J:56777] synonym: "abnormal suprabasal layer" EXACT [] is_a: MT:0001231 ! basal cell layer morphology [Term] id: MT:0001235 name: suprabasal layer organization namespace: Trait.ontology def: "anomalous organization of the suprabasal layer of the skin" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] is_a: MT:0001233 ! suprabasal layer morphology [Term] id: MT:0001236 name: spinous layer morphology namespace: Trait.ontology def: "structual or developmental anomaly of the layer of polyhedral cells in the epidermis; shrinkage and adhesion of these cells gives a spiny or prickly appearance" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal prickle cell layer" EXACT [] synonym: "abnormal stratum spinosum" EXACT [] is_a: MT:0001216 ! epidermal layer morphology [Term] id: MT:0001237 name: spinous cell size namespace: Trait.ontology def: "increased size of the cells of the spinous layer of the epidermis" [J:47225] synonym: "enlarged prickle cells" EXACT [] is_a: MT:0001236 ! spinous layer morphology [Term] id: MT:0001238 name: epidermal spinous layer thickness namespace: Trait.ontology def: "reduced thickness of the stratum spinosum; the polyhedral cell layer" [J:15108, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "thin prickle cell layer" EXACT [] synonym: "thin spinous layer" EXACT [] synonym: "thin stratum spinosum" EXACT [] is_a: MT:0001236 ! spinous layer morphology [Term] id: MT:0001239 name: granular layer morphology namespace: Trait.ontology def: "structural or developmental anomaly of the layer of flattened cells containing basophilic granules of keratohyalin and lying just above the stratum spinosum (spiny layer) of the epidermis" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal stratum granulosum" EXACT [] is_a: MT:0001216 ! epidermal layer morphology [Term] id: MT:0001240 name: cornified layer morphology namespace: Trait.ontology def: "structural or developmental anomaly of the outer layer of the epidermis, consisting of several layers of flat keratinized non-nucleated cells" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal horny layer" EXACT [] synonym: "abnormal stratum corneum" EXACT [] is_a: MT:0001216 ! epidermal layer morphology [Term] id: MT:0001242 name: cornified layer thickness namespace: Trait.ontology alt_id: MT:0001223 def: "increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133] synonym: "epidermal hyperkeratosis" EXACT [] synonym: "thickened cornified layer" EXACT [] synonym: "thickened horny layer" EXACT [] synonym: "thickened stratum corneum" EXACT [] synonym: "thicker cornified layer" EXACT [] synonym: "thicker horny layer" EXACT [] synonym: "thicker stratum corneum" EXACT [] is_a: MT:0001240 ! cornified layer morphology [Term] id: MT:0001243 name: dermal layer morphology namespace: Trait.ontology def: "malformed or atypical condition of the dermal layer of the skin" [J:56777, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal corium" EXACT [] synonym: "abnormal cutis vera" EXACT [] synonym: "abnormal dermal layer" EXACT [] synonym: "abnormal dermis" EXACT [] is_a: MT:0002060 ! skin morphology [Term] id: MT:0001245 name: dermal layer thickness namespace: Trait.ontology def: "increased depth of the dermis" [J:65033] synonym: "thick corium" EXACT [] synonym: "thick dermis" EXACT [] synonym: "thickened corium" EXACT [] synonym: "thickened dermal layer" EXACT [] synonym: "thickened dermis" EXACT [] is_a: MT:0001243 ! dermal layer morphology [Term] id: MT:0001246 name: mixed cellular infiltration to dermis namespace: Trait.ontology def: "gradual accumulation of mixed cell types in the dermis that are not normally found there" [J:65416] is_a: MT:0001243 ! dermal layer morphology [Term] id: MT:0001247 name: dermal cysts namespace: Trait.ontology def: "abnormal membranous sacs appearing in the dermis" [J:53379] is_a: MT:0001243 ! dermal layer morphology [Term] id: MT:0001248 name: connective tissue morphology namespace: Trait.ontology def: "missing supporting framework of a tissue or the body; formed of fibrous or ground substance" [J:56777, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "absence of connective tissue" EXACT [] is_a: MT:0005395 ! other trait [Term] id: MT:0001250 name: superficial dermis morphology namespace: Trait.ontology def: "anomalous structure of the more superficial, thin layer of the dermis that interdigitates with the epidermis" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal corpus papillary" EXACT [] synonym: "abnormal papillary layer" EXACT [] synonym: "abnormal stratum papillare" EXACT [] synonym: "abnormal stratum papillare corii" EXACT [] synonym: "abnormal superficial dermis" EXACT [] is_a: MT:0001243 ! dermal layer morphology [Term] id: MT:0001251 name: superficial dermis cellularity namespace: Trait.ontology def: "increased cell density of the superficial layer" [J:56777] synonym: "hypercellularity of superficial dermis" EXACT [] is_a: MT:0001250 ! superficial dermis morphology [Term] id: MT:0001253 name: body height namespace: Trait.ontology def: "anomalous shoulder to floor distance compared to controls" [dlb:Donna Burkart_Mouse Genome Informatics Curator] subset: slim_cattle subset: slim_pig xref: GO:0040007 xref: GO:0040014 is_a: MT:0003956 ! body size [Term] id: MT:0001256 name: body length namespace: Trait.ontology def: "anomalous crown to tail distance compared to controls" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] subset: slim_pig xref: GO:0040007 xref: GO:0040014 is_a: MT:0003956 ! body size [Term] id: MT:0001259 name: body weight namespace: Trait.ontology def: "anomaly in average weight compared to controls" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] subset: slim_cattle subset: slim_chkn subset: slim_pig is_a: MT:0002089 ! postnatal growth/weight/body size [Term] id: MT:0001261 name: obese namespace: Trait.ontology def: "excessively fat; an increase in fat in the subcutaneous connective tissue" [cml:Cathleen M. Lutz_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "obesity" EXACT [] is_a: MT:0001259 ! body weight [Term] id: MT:0001263 name: weight loss namespace: Trait.ontology def: "progressive reduction of body weight below normal average for age" [J:45400] subset: slim_cattle subset: slim_chkn is_a: MT:0001259 ! body weight [Term] id: MT:0001268 name: barrel chest namespace: Trait.ontology def: "distended circumference of the thoracic and abdominal areas" [J:55583] is_a: MT:0004134 ! chest morphology [Term] id: MT:0001274 name: vibrissae shape namespace: Trait.ontology alt_id: MT:0001275 def: "physical form of the whiskers" [J:47620] is_a: MT:0002098 ! vibrissae morphology [Term] id: MT:0001277 name: vibrissae pattern namespace: Trait.ontology def: "organization of the whiskers" [J:65301] synonym: "tangled whiskers" EXACT [] is_a: MT:0002098 ! vibrissae morphology [Term] id: MT:0001280 name: vibrissae retention namespace: Trait.ontology def: "ability to retain the whiskers" [J:45400] synonym: "loss of whiskers" EXACT [] is_a: MT:0002098 ! vibrissae morphology [Term] id: MT:0001281 name: vibrissae length namespace: Trait.ontology def: "longer average length of the whiskers" [J:65037] synonym: "increased whisker length" EXACT [] is_a: MT:0002098 ! vibrissae morphology [Term] id: MT:0001283 name: vibrissae density namespace: Trait.ontology def: "few and widely spaced whiskers" [J:65302] synonym: "sparse whiskers" EXACT [] is_a: MT:0002098 ! vibrissae morphology [Term] id: MT:0001286 name: eye development namespace: Trait.ontology def: "malformation or arrest of differentiation of the visual organ" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, J:49840, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "eye development abnormalities" EXACT [] xref: GO:0001654 is_a: MT:0002092 ! eye morphology [Term] id: MT:0001288 name: lens induction namespace: Trait.ontology def: "malformation of or failure to form the transparent, biconvex structure of the eye which is situated behind the iris and in front of the vitreous humor" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] synonym: "lens induction abnormalities" EXACT [] is_a: MT:0005545 ! lens development [Term] id: MT:0001289 name: persistence of hyaloid capillary system namespace: Trait.ontology def: "failure of the degeneration of the transient vascular system of the eye during development" [J:49840] is_a: MT:0001286 ! eye development [Term] id: MT:0001290 name: time of eyelid opening namespace: Trait.ontology def: "late average time for the first postnatal eye opening" [J:17792] synonym: "delayed eye opening" EXACT [] is_a: MT:0003671 ! eyelid opening [Term] id: MT:0001292 name: lens vesicle development namespace: Trait.ontology def: "malformation or abnormal patterning of the lens vesicle of the eye" [J:49424] synonym: "lens vesicle development abnormalities" EXACT [] is_a: MT:0001288 ! lens induction [Term] id: MT:0001293 name: anophthalmia namespace: Trait.ontology alt_id: MT:0001298 def: "congenital absence of all tissues of the eyes" [cml:Cathleen M. Lutz_Mouse Genome Informatics Curator, J:71979, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "absence of eyes" EXACT [] synonym: "absent eyes" EXACT [] is_a: MT:0002697 ! eye size [Term] id: MT:0001299 name: eye distance/ position namespace: Trait.ontology def: "abnormal placement of the eyes in relation to each other or in relation to other craniofacial structures" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] synonym: "eye distance/ position abnormalities" EXACT [] is_a: MT:0002092 ! eye morphology [Term] id: MT:0001300 name: distance between the eyes namespace: Trait.ontology def: "increased distance between the eyes " [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001299 ! eye distance/ position [Term] id: MT:0001301 name: inner hair cell stereocilia number namespace: Trait.ontology def: "number of the nonmotile, actin-filled specialized microvilli (stereocilia) normally arrayed on cochlear inner hair cells" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0000893 ! cochlear hair cell stereocilia number is_a: MT:0001180 ! inner hair cell stereociliary bundle morphology [Term] id: MT:0001303 name: lens morphology namespace: Trait.ontology def: "malformed transparent structure of the eye responsible for focusing light rays" [J:40203, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "lens abnormalities" EXACT [] is_a: MT:0002093 ! cornea/lens morphology [Term] id: MT:0001304 name: cataracts namespace: Trait.ontology def: "complete or partial opacity of the lens" [J:65031] synonym: "cataract" EXACT [] synonym: "cataracts/ lens opacity" EXACT [] synonym: "lens opacity" EXACT [] is_a: MT:0001303 ! lens morphology is_a: MT:0005545 ! lens development [Term] id: MT:0001305 name: lens size namespace: Trait.ontology def: "increased size of the transparent structure of the eye responsible for focusing light rays" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001303 ! lens morphology [Term] id: MT:0001307 name: fused cornea/lens namespace: Trait.ontology alt_id: MT:0001315 def: "condition in which the transparent anterior portion of the fibrous coat of the eye is joined to the transparent biconvex cellular refractive structure lying between the iris and vitreous humor of the eye" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "cornea/lens fusion" EXACT [] is_a: MT:0001312 ! cornea morphology is_a: MT:0005545 ! lens development [Term] id: MT:0001308 name: lens polarity namespace: Trait.ontology def: "failure of normal orientation of the lens during development" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, J:49840, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal lens polarization" EXACT [] is_a: MT:0001292 ! lens vesicle development [Term] id: MT:0001309 name: hydropic eye lens fibers namespace: Trait.ontology def: "swollen cortical fibers of the eye lens" [J:14285] is_a: MT:0002840 ! lens fiber morphology [Term] id: MT:0001310 name: conjunctiva morphology namespace: Trait.ontology def: "malformation or atrophy of the mucous membrane that lines the inner surface of the eyelids and the front of the eyeball" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] synonym: "conjunctiva abnormalities" EXACT [] is_a: MT:0005193 ! anterior eye segment morphology [Term] id: MT:0001312 name: cornea morphology namespace: Trait.ontology def: "malformation or absence of the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [MeSH:National Library of Medicine_Medical Subject Headings, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "cornea abnormalities" EXACT [] is_a: MT:0002093 ! cornea/lens morphology [Term] id: MT:0001313 name: incidence of corneal inflammation namespace: Trait.ontology def: "greater than average and persistent occurrence of corneal irritation" [J:4606] is_a: MT:0001312 ! cornea morphology is_a: MT:0001846 ! tissue specific inflammatory response [Term] id: MT:0001314 name: corneal opacity namespace: Trait.ontology def: "complete or partial clouding of the cornea" [jte:Janan T. Eppig_Mouse Genome Informatics, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001312 ! cornea morphology [Term] id: MT:0001316 name: corneal scarring namespace: Trait.ontology def: "appearance of fibrous tissue on the cornea after healing in response to injury " [J:30249] is_a: MT:0001312 ! cornea morphology [Term] id: MT:0001317 name: pupil morphology namespace: Trait.ontology def: "structural anomaly of the central circular aperture of the iris through which light rays enter the eye" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "pupil abnormalities" EXACT [] is_a: MT:0001322 ! iris morphology [Term] id: MT:0001318 name: pupil opacity namespace: Trait.ontology def: "milky or cloudy appearance of the central circular aperture of the iris through which light rays normally enter the eye" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001317 ! pupil morphology [Term] id: MT:0001319 name: irregularly shaped pupil namespace: Trait.ontology def: "shape defects in the aperture of the iris through which light rays enter the eye, usually circular " [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "anisocoria" EXACT [] is_a: MT:0001317 ! pupil morphology [Term] id: MT:0001321 name: pupil size namespace: Trait.ontology def: "larger than normal size of the central circular aperture of the iris through which light rays enter the eye" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001317 ! pupil morphology [Term] id: MT:0001322 name: iris morphology namespace: Trait.ontology def: "structural anomaly of the adjustable membrane, composed of the stroma and pigmented epithelium, located just in front of the crystalline lens within the eye" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "iris abnormalities" EXACT [] is_a: MT:0005194 ! anterior uvea morphology [Term] id: MT:0001323 name: inner hair cell stereocilia size namespace: Trait.ontology def: "length, width, or volume of the the nonmotile, actin-filled specialized microvilli (stereocilia) normally arrayed on cochlear inner hair cells" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0000894 ! cochlear hair cell stereocilia size is_a: MT:0001180 ! inner hair cell stereociliary bundle morphology [Term] id: MT:0001324 name: eye pigmentation namespace: Trait.ontology def: "change in the normal black pigmentation of the eye to another color, or lack of color" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0001186 ! pigmentation trait is_a: MT:0002092 ! eye morphology [Term] id: MT:0001325 name: retina morphology namespace: Trait.ontology def: "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "retina abnormalities" EXACT [] is_a: MT:0002864 ! ocular fundus morphology [Term] id: MT:0001326 name: retinal integrity namespace: Trait.ontology def: "pathological change in the thin layer of neural tissue lining the back of the eyeball, which contains visual receptors and can result in the impairment or cessation of retinal neural function" [NMF:Stephanie Pretel_Neuroscience Mutagenesis Facility Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0005253 ! eye physiology [Term] id: MT:0001328 name: retinal layer organization namespace: Trait.ontology def: "delaminated or mispositioned sheets of cells comprising the optic part of the retina" [J:33400] is_a: MT:0003727 ! retinal layer morphology [Term] id: MT:0001329 name: retina cell number namespace: Trait.ontology def: "greater than normal number of cells in the thin layer of neural tissue lining the back of the eyeball which contains visual receptors" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "hyperplastic retina" EXACT [] is_a: MT:0001325 ! retina morphology [Term] id: MT:0001330 name: optic nerve morphology namespace: Trait.ontology alt_id: MT:0001058 alt_id: MT:0001287 def: "malformation, misprojection or atrophy in the second cranial nerve which is responsible for conveying visual information from the retina to the brain; it extends from the retina to the optic chiasma where part of its fibers become the optic tract and cross to the opposite side and pass to the geniculate bodies" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] synonym: "abnormal optic disc" EXACT [] synonym: "abnormal optic disc morphology" EXACT [] synonym: "CN-II" EXACT [] synonym: "optic disc abnormalities" EXACT [] synonym: "optic nerve abnormalities" EXACT [] is_a: MT:0001056 ! cranial nerve morphology is_a: MT:0005195 ! posterior eye segment morphology [Term] id: MT:0001332 name: optic nerve innervation namespace: Trait.ontology alt_id: MT:0001060 def: "misprojection or aberrant target finding of the second cranial nerve which is responsible for conveying visual information from the retina to the brain" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] synonym: "abnormal innervation" EXACT [] synonym: "optic nerve innervation abnormalities" EXACT [] is_a: MT:0001330 ! optic nerve morphology [Term] id: MT:0001334 name: optic tract size namespace: Trait.ontology def: "volume, width, or length of the band of optic nerve fibers running from the optic chiasma to the lateral geniculate body and midbrain" [MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0004267 ! optic tract morphology [Term] id: MT:0001335 name: inner hair cell synaptic ribbon morphology namespace: Trait.ontology def: "form or internal structure of the presynaptic active zone of mature cochlear IHCs which usually contain a single synaptic ribbon, i.e. a submicrometer, electron-dense structure tethering synaptic vesicles; each spiral ganglion neuron receives input from only one IHC synapse " [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] synonym: "IHC synaptic ribbon morphology" RELATED [] is_a: MT:0004393 ! cochlear inner hair cell morphology [Term] id: MT:0001336 name: active-zone-anchored inner hair cell synaptic ribbon morphology namespace: Trait.ontology def: "form or number of the usually single synaptic ribbon, a characteristic osmiophilic, electron-dense structure to which synaptic vesicles are tethered at the active zone of the cochlear inner hair cell afferent synapse" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0001335 ! inner hair cell synaptic ribbon morphology [Term] id: MT:0001337 name: eye moisture level namespace: Trait.ontology def: "absence of natural or normal moisture in the eye" [J:53284] is_a: MT:0001348 ! lacrimal gland physiology [Term] id: MT:0001340 name: eyelid morphology namespace: Trait.ontology def: "malformation of the skin folds covering the front of the eyeball" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] synonym: "abnormal eyelids" EXACT [] synonym: "eyelid abnormalities" EXACT [] is_a: MT:0002092 ! eye morphology [Term] id: MT:0001343 name: pronounced eyelids namespace: Trait.ontology def: "strongly protruding eyelids" [J:65032] is_a: MT:0001340 ! eyelid morphology [Term] id: MT:0001344 name: blepharoptosis namespace: Trait.ontology alt_id: MT:0006161 def: "ptosis, drooping eyelids " [J:24414, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "drooping eyelids" EXACT [] synonym: "ptosis" EXACT [] synonym: "ptosis of the eye" EXACT [] is_a: MT:0001340 ! eyelid morphology [Term] id: MT:0001345 name: meibomian gland size namespace: Trait.ontology alt_id: MT:0000651 def: "wasting of the sebaceous glands embedded in the tarsal plate of each eyelid resulting in reduced size" [J:65146] synonym: "Atrophic Glandulae Tarsales" EXACT [] synonym: "atrophic glandulae tarsales" EXACT [] synonym: "atrophic meibomian glands" EXACT [] synonym: "Atrophic Tarsal Glands" EXACT [] synonym: "atrophic tarsal glands" EXACT [] synonym: "Palpebral Glands" EXACT [] is_a: MT:0005252 ! meibomian gland morphology [Term] id: MT:0001346 name: lacrimal gland morphology namespace: Trait.ontology alt_id: MT:0000682 def: "malformation of the glands that secrete tears" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8, tc:Teresa Chu_Mouse Genome Informatics Curator] synonym: "abnormal lachrymal glands" EXACT [] synonym: "abnormal lacrimal system" EXACT [] synonym: "abnormal tear ducts" EXACT [] is_a: MT:0002092 ! eye morphology is_a: MT:0002163 ! gland morphology [Term] id: MT:0001348 name: lacrimal gland physiology namespace: Trait.ontology def: "aberrant function of the glands that secrete tears" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0005253 ! eye physiology [Term] id: MT:0001349 name: tear production namespace: Trait.ontology def: "an unusually high amount of fluid secreted by the lacrimal glands, often resulting in overflow of fluid from the eye" [hdene:Howard Dene_Mouse Genome Informatics Curator, J:38104] is_a: MT:0001348 ! lacrimal gland physiology [Term] id: MT:0001359 name: patterning of the organ of Corti namespace: Trait.ontology def: "organization of the various cell types within the organ of Corti into a set number of distinct rows" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0000042 ! organ of Corti [Term] id: MT:0001360 name: social investigation namespace: Trait.ontology def: "altered behavior of animals to approach and examine other animals" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0002557 ! social/conspecific interaction [Term] id: MT:0001365 name: Dieters cell number namespace: Trait.ontology def: "number of the supporting cells of the spiral organ which are attached to the basement membrane and receive the hair cells between their free extremities" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0004302 ! Dieters cell morphology [Term] id: MT:0001366 name: pillar cell number namespace: Trait.ontology def: "number of the supporting cells that form the inner and outer walls of the tunnel in the organ of Corti " [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0003825 ! pillar cell morphology [Term] id: MT:0001373 name: spiral ligament integrity namespace: Trait.ontology def: "susceptibility of the spiral ligament to loss or degeneration" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0004288 ! spiral ligament morphology [Term] id: MT:0001375 name: mating preference namespace: Trait.ontology def: "deviation from the usual preference of a male to initiate sexual contact with a receptive female; usually refers to males that initiate sexual behavior with males and females indiscriminately" [J:76339] is_a: MT:0002566 ! sexual interaction [Term] id: MT:0001376 name: mating receptivity namespace: Trait.ontology def: "deviation from the normal cycle or inability of females to respond favorably to males that initiate sexual behavior" [J:51468] is_a: MT:0002566 ! sexual interaction [Term] id: MT:0001377 name: copulation namespace: Trait.ontology def: "reduced or absent attempt of sexual contact between a male and a receptive female" [MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0002566 ! sexual interaction [Term] id: MT:0001378 name: ejaculation namespace: Trait.ontology def: "anomalies in the ability to propulse semen from the genital ducts and the urethra to the exterior" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0003698 ! male reproductive system physiology [Term] id: MT:0001379 name: penile erection function namespace: Trait.ontology def: "altered ability to achieve a rigid and elevated state of the penis when the erectile tissue becomes filled with blood" [MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0003698 ! male reproductive system physiology [Term] id: MT:0001382 name: nursing namespace: Trait.ontology def: "females do not nurse pups or nurse pups infrequently" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0001386 ! maternal nurturing [Term] id: MT:0001384 name: pup retrieval namespace: Trait.ontology def: "a mother does not retrieve stray pups to the nest or delays retrieving stray pups" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0001386 ! maternal nurturing [Term] id: MT:0001385 name: pup cannibalization namespace: Trait.ontology def: "the killing and eating of newborn mice by the mother; can be a normal response if the mother does not recognize the pups as her own" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0001386 ! maternal nurturing [Term] id: MT:0001386 name: maternal nurturing namespace: Trait.ontology alt_id: MT:0001381 def: "failure of mothers to tend offspring" [J:39801] synonym: "abnormal care for newborns" EXACT [] synonym: "maternal nurturing defect" EXACT [] is_a: MT:0002068 ! parental behavior [Term] id: MT:0001387 name: spiral ligament size namespace: Trait.ontology def: "length, width, or area of the spiral ligament" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0004288 ! spiral ligament morphology [Term] id: MT:0001388 name: stationary movement namespace: Trait.ontology is_a: MT:0003491 ! voluntary movement [Term] id: MT:0001389 name: eye movements namespace: Trait.ontology is_a: MT:0001388 ! stationary movement is_a: MT:0005253 ! eye physiology [Term] id: MT:0001391 name: tail movements namespace: Trait.ontology alt_id: MT:0000590 is_a: MT:0001388 ! stationary movement [Term] id: MT:0001392 name: locomotor activity namespace: Trait.ontology subset: slim_pig synonym: "locomotion" EXACT [] is_a: MT:0003491 ! voluntary movement [Term] id: MT:0001393 name: coordination of voluntary muscular movement namespace: Trait.ontology is_a: MT:0001516 ! motor coordination/ balance is_a: MT:0003312 ! locomotor coordination [Term] id: MT:0001398 name: strial basal cell tight junction morphology namespace: Trait.ontology def: "structure of the tight junctions between basal cells of stria vascularis, resulting in the paracellular barrier between basal cells; closing the intrastrial space off from the perilymph and establishing its electrical isolation" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0004365 ! strial basal cell morphology [Term] id: MT:0001399 name: activity level namespace: Trait.ontology alt_id: MT:0001397 alt_id: MT:0001403 is_a: MT:0003313 ! locomotor activation [Term] id: MT:0001404 name: spontaneous movement namespace: Trait.ontology is_a: MT:0003313 ! locomotor activation [Term] id: MT:0001406 name: gait namespace: Trait.ontology is_a: MT:0003312 ! locomotor coordination [Term] id: MT:0001407 name: stride length namespace: Trait.ontology is_a: MT:0003312 ! locomotor coordination [Term] id: MT:0001412 name: scratching namespace: Trait.ontology is_a: MT:0001440 ! grooming behavior [Term] id: MT:0001413 name: response to new environment namespace: Trait.ontology subset: slim_pig is_a: MT:0001449 ! learning/ memory is_a: MT:0003107 ! response to novelty [Term] id: MT:0001414 name: strial intermediate cell number namespace: Trait.ontology def: "number of the melanocytes (i.e. crest-derived intermediate cells) normally located within the intrastrial space; loss of strial intermediate cells is known to lead to loss of the endocochlear potential" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0004367 ! strial intermediate cell morphology [Term] id: MT:0001416 name: strial marginal cell number namespace: Trait.ontology def: "number of the polarized columnar cells of epithelial origin which cover the lateral surface of the cochlear duct, secrete K+ and form a continuous sheet in contact with the endolymph" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0004366 ! strial marginal cell morphology [Term] id: MT:0001417 name: exploration in new environment namespace: Trait.ontology subset: slim_pig synonym: "exploration" RELATED [] is_a: MT:0001413 ! response to new environment [Term] id: MT:0001418 name: tectorial membran size namespace: Trait.ontology def: "length, width, or area of the tectorial membrane" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0003149 ! tectorial membrane morphology [Term] id: MT:0001421 name: scala media size namespace: Trait.ontology def: "length, width, area, or volume of the scala media" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0003169 ! scala media morphology [Term] id: MT:0001422 name: drinking behavior namespace: Trait.ontology is_a: MT:0002069 ! eating/drinking behavior [Term] id: MT:0001423 name: liquid preference namespace: Trait.ontology is_a: MT:0001422 ! drinking behavior [Term] id: MT:0001424 name: water consumption namespace: Trait.ontology is_a: MT:0001422 ! drinking behavior [Term] id: MT:0001425 name: alcohol consumption namespace: Trait.ontology synonym: "ethanol consumption" EXACT [] is_a: MT:0002568 ! response to addictive substances [Term] id: MT:0001429 name: dehydration namespace: Trait.ontology def: "excessive water loss from the body or from an organ or bodily part" [J:50053, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001784 ! fluid regulation [Term] id: MT:0001431 name: eating behavior namespace: Trait.ontology alt_id: MT:0001430 subset: slim_cattle subset: slim_chkn subset: slim_pig is_a: MT:0002069 ! eating/drinking behavior [Term] id: MT:0001432 name: food preference namespace: Trait.ontology subset: slim_chkn is_a: MT:0001431 ! eating behavior [Term] id: MT:0001435 name: suckling reflex namespace: Trait.ontology is_a: MT:0001436 ! suckling behavior [Term] id: MT:0001436 name: suckling behavior namespace: Trait.ontology is_a: MT:0001431 ! eating behavior [Term] id: MT:0001437 name: swallowing reflex namespace: Trait.ontology is_a: MT:0001436 ! suckling behavior [Term] id: MT:0001440 name: grooming behavior namespace: Trait.ontology alt_id: MT:0001439 is_a: MT:0005386 ! behavior/neurological trait [Term] id: MT:0001444 name: scala tympani size namespace: Trait.ontology def: "length, width, area, or volume of the scala tympani" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0003167 ! scala tympani morphology [Term] id: MT:0001445 name: vestibular hair cell stereociliary bundle morphology namespace: Trait.ontology def: "form, structure, number, or organization of the typical staircase-like arrangement of the mechanosensitive hair bundles which are composed of thick long microvilli (stereocilia) and are located at the apical end of vestibular hair cells of the utricle and saccule" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] synonym: "vestibular hair bundle morphology" RELATED [] synonym: "vestibular hair cell stereocilia morphology" RELATED [] is_a: MT:0002623 ! vestibular hair cell morphology [Term] id: MT:0001446 name: whisker trimming namespace: Trait.ontology is_a: MT:0001440 ! grooming behavior [Term] id: MT:0001447 name: nest building behavior namespace: Trait.ontology is_a: MT:0002557 ! social/conspecific interaction [Term] id: MT:0001449 name: learning/ memory namespace: Trait.ontology subset: slim_pig is_a: MT:0002063 ! learning/memory/conditioning [Term] id: MT:0001450 name: vestibular hair bundle inter-stereocilial links namespace: Trait.ontology def: "form, structure, or number of the morphologically and biochemically distinct link types that extend between the stereocilia of vestibular hair bundles" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0001445 ! vestibular hair cell stereociliary bundle morphology [Term] id: MT:0001451 name: vestibular hair bundle shaft connectors namespace: Trait.ontology def: "form, structure, or number of the links that connect the shafts of neighboring stereocilia in vestibular hair bundles; each shaft connector is composed of a ruthenium red-reactive, electron-dense particle that is connected to the plasma membrane by several fine strands of variable length" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0001450 ! vestibular hair bundle inter-stereocilial links [Term] id: MT:0001452 name: vestibular hair cell stereocilia number namespace: Trait.ontology def: "number of the nonmotile, actin-filled specialized microvilli (stereocilia) which are normally arrayed on vestibular hair cells in a staircase-like pattern" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0001445 ! vestibular hair cell stereociliary bundle morphology [Term] id: MT:0001454 name: cued conditioning behavior namespace: Trait.ontology alt_id: MT:0001453 is_a: MT:0002062 ! conditioning behavior [Term] id: MT:0001455 name: vestibular hair cell stereocilia size namespace: Trait.ontology def: "lenght, width, or volume of the nonmotile, actin-filled specialized microvilli (stereocilia) which are normally arrayed on vestibular hair cells in a staircase-like pattern" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0001445 ! vestibular hair cell stereociliary bundle morphology [Term] id: MT:0001456 name: otic capsule size namespace: Trait.ontology def: "length, width, area, or volume of the cartilage or bony capsule surrounding the inner ear mechanism" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0000039 ! otic capsule morphology [Term] id: MT:0001457 name: vestibular dark cell morphology namespace: Trait.ontology def: "form or structure of he nonsensory epithelial cells located above the vestibular melanocytes and adjacent to the sensory structures in the utricle and in the ampullae at the ends of each of the semicircular canals; these cells provide and maintain the high K+ ionic environment within the vestibular labyrinth and are therefore homologous to the marginal cells of the stria vascularis; they are joined to each other by tight junctions and provide a barrier between endolymph and perilymph" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0000034 ! vestibule morphology [Term] id: MT:0001458 name: object recognition memory namespace: Trait.ontology is_a: MT:0001449 ! learning/ memory [Term] id: MT:0001459 name: vestibule size namespace: Trait.ontology def: "length, width, area, or volume of the vestibule" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0000034 ! vestibule morphology [Term] id: MT:0001460 name: olfactory -discrimination memory namespace: Trait.ontology is_a: MT:0002802 ! discrimination learning [Term] id: MT:0001461 name: vestibular dark cell integrity namespace: Trait.ontology def: "susceptibility of vestibular dark cells to loss or degeneration" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0001457 ! vestibular dark cell morphology [Term] id: MT:0001462 name: avoidance learning behavior namespace: Trait.ontology is_a: MT:0002062 ! conditioning behavior [Term] id: MT:0001463 name: spatial learning namespace: Trait.ontology alt_id: MT:0001466 alt_id: MT:0001467 is_a: MT:0001449 ! learning/ memory [Term] id: MT:0001464 name: incus size namespace: Trait.ontology def: "length, width, or volume of the incus" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0003739 ! middle ear ossicle size is_a: MT:0005106 ! incus morphology [Term] id: MT:0001465 name: malleus size namespace: Trait.ontology def: "length, width, or volume of the malleus" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0000029 ! malleus morphology is_a: MT:0003739 ! middle ear ossicle size [Term] id: MT:0001468 name: temporal memory namespace: Trait.ontology is_a: MT:0001449 ! learning/ memory [Term] id: MT:0001469 name: contextual conditioning namespace: Trait.ontology is_a: MT:0001468 ! temporal memory is_a: MT:0002062 ! conditioning behavior [Term] id: MT:0001470 name: stapedial artery integrity namespace: Trait.ontology def: "any measurable characteristic pertaining to the the structural completeness or structural soundness of the small artery that passes through the ring of the stapes; while the stapedial artery is a temporary artery thought to disappear at late embryonic stage in humans, the mouse stapedial artery is complete by E13 and persists into adulthood" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] is_a: MT:0003410 ! artery integrity is_a: MT:0005107 ! stapes morphology [Term] id: MT:0001485 name: pinna reflex namespace: Trait.ontology alt_id: MT:0001962 def: "response to an auditory stimulus by a characteristic ear twitch" [J:64900] synonym: "ear twitch response" EXACT [] synonym: "Preyer's reflex" EXACT [] is_a: MT:0001961 ! reflex is_a: MT:0003878 ! ear physiology [Term] id: MT:0001486 name: startle reflex namespace: Trait.ontology is_a: MT:0001961 ! reflex is_a: MT:0003878 ! ear physiology [Term] id: MT:0001490 name: vibrissae reflex namespace: Trait.ontology alt_id: MT:0001276 alt_id: MT:0001969 is_a: MT:0001961 ! reflex [Term] id: MT:0001492 name: piloerection namespace: Trait.ontology def: "the involuntary bristling of hairs" [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "goosebumps" EXACT [] is_a: MT:0001961 ! reflex [Term] id: MT:0001501 name: sleep pattern namespace: Trait.ontology alt_id: MT:0002004 synonym: "abnormal sleep pattern" EXACT [] is_a: MT:0002070 ! sleep pattern/circadian rhythm [Term] id: MT:0001502 name: circadian rhythm namespace: Trait.ontology alt_id: MT:0002005 synonym: "abnormal circadian rhythm" EXACT [] is_a: MT:0002070 ! sleep pattern/circadian rhythm [Term] id: MT:0001504 name: posture namespace: Trait.ontology is_a: MT:0002066 ! motor capabilities/coordination/movement [Term] id: MT:0001505 name: body posture namespace: Trait.ontology is_a: MT:0001504 ! posture [Term] id: MT:0001510 name: coat appearance namespace: Trait.ontology def: "coat that looks different from the usual state" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] subset: slim_pig synonym: "abnormal appearance of the fur" EXACT [] is_a: MT:0000367 ! coat/ hair morphology [Term] id: MT:0001511 name: disheveled coat namespace: Trait.ontology def: "coat that looks generally unkempt" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "disheveled appearance of the fur" EXACT [] is_a: MT:0001510 ! coat appearance [Term] id: MT:0001513 name: response to being lifted by the tail namespace: Trait.ontology is_a: MT:0001961 ! reflex is_a: MT:0003492 ! involuntary movement [Term] id: MT:0001515 name: grip strength namespace: Trait.ontology is_a: MT:0004262 ! physical strength [Term] id: MT:0001516 name: motor coordination/ balance namespace: Trait.ontology is_a: MT:0002066 ! motor capabilities/coordination/movement [Term] id: MT:0001522 name: swimming ability namespace: Trait.ontology is_a: MT:0001516 ! motor coordination/ balance is_a: MT:0003312 ! locomotor coordination [Term] id: MT:0001524 name: limb coordination namespace: Trait.ontology is_a: MT:0001516 ! motor coordination/ balance is_a: MT:0003312 ! locomotor coordination [Term] id: MT:0001525 name: balance namespace: Trait.ontology is_a: MT:0001516 ! motor coordination/ balance [Term] id: MT:0001526 name: placing response namespace: Trait.ontology synonym: "abnormal reaching response" EXACT [] synonym: "abnormal visual placing" EXACT [] is_a: MT:0001516 ! motor coordination/ balance [Term] id: MT:0001527 name: walking movement namespace: Trait.ontology is_a: MT:0001516 ! motor coordination/ balance is_a: MT:0003312 ! locomotor coordination [Term] id: MT:0001529 name: vocalization namespace: Trait.ontology alt_id: MT:0001528 synonym: "Vocalization" EXACT [] is_a: MT:0002071 ! other behavior [Term] id: MT:0001533 name: skeleton physiology namespace: Trait.ontology def: "anomalous function of the bony framework of the body" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] subset: slim_chkn synonym: "abnormal bone/ skeleton physiology" EXACT [] synonym: "bone/ skeletal physiology abnormalities" EXACT [] is_a: MT:0005390 ! skeleton trait [Term] id: MT:0001539 name: number of caudal vertebrae namespace: Trait.ontology def: "reduced number of the bony segments of the tail" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "decreased number of tail vertebrae" EXACT [] is_a: MT:0002759 ! caudal vertebrae morphology relationship: part_of MT:0000138 ! vertebrae number [Term] id: MT:0001541 name: osteoclast physiology namespace: Trait.ontology def: "reduced ability or inability of osteoclasts to absorb and remove osseous tissue" [J:58795, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001533 ! skeleton physiology [Term] id: MT:0001542 name: bone strength namespace: Trait.ontology def: "change in the ability of bone to endure the application of force without yielding or breaking" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] subset: slim_chkn is_a: MT:0001533 ! skeleton physiology [Term] id: MT:0001544 name: cardiovascular system physiology namespace: Trait.ontology alt_id: MT:0000302 alt_id: MT:0001623 alt_id: MT:0001626 alt_id: MT:0002130 def: "any measurable characteristic related to the function of or processes in the heart or vasculature" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] subset: slim_chkn relationship: part_of MT:0005385 ! cardiovascular system trait [Term] id: MT:0001545 name: hematopoietic system physiology namespace: Trait.ontology def: "anomalous function of the fluid and/or its suspended elements that circulate(s) through the heart, arteries, capillaries, and veins" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal hemopoietic system physiology" EXACT [] synonym: "blood defects" EXACT [] synonym: "blood physiology abnormalities" EXACT [] is_a: MT:0005397 ! hematopoietic system trait [Term] id: MT:0001547 name: lipid level namespace: Trait.ontology def: "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] subset: slim_cattle subset: slim_chkn subset: slim_pig is_a: MT:0002118 ! lipid homeostasis [Term] id: MT:0001553 name: circulating free fatty acids level namespace: Trait.ontology def: "anomalous blood concentrations of organic, monobasic acids derived from hydrocarbons and which are complexed with serum albumin for transport; they are saturated and unsaturated" [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal circulating fatty acid level" EXACT [] synonym: "abnormal FFA level" EXACT [] synonym: "abnormal free fatty acids level" EXACT [] is_a: MT:0003949 ! circulating lipid level is_a: MT:0005280 ! fatty acid level [Term] id: MT:0001560 name: circulating insulin level namespace: Trait.ontology alt_id: MT:0000191 def: "anomalous blood concentration of this polypeptide hormone, secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] subset: slim_chkn synonym: "abnormal insulin level" EXACT [] is_a: MT:0002078 ! glucose homeostasis [Term] id: MT:0001562 name: circulating calcium level namespace: Trait.ontology alt_id: MT:0000193 alt_id: MT:0001767 def: "anomalous concentration in the blood of this bivalent element" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "abnormal calcium level" EXACT [] is_a: MT:0000179 ! blood chemistry is_a: MT:0004231 ! calcium ion homeostasis [Term] id: MT:0001565 name: circulating phosphate level namespace: Trait.ontology alt_id: MT:0000196 alt_id: MT:0001772 def: "anomalous blood concentrations of this salt or ester of phosphoric acid; often associated with anomalous bone mineralization " [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal phosphate level" EXACT [] is_a: MT:0000179 ! blood chemistry is_a: MT:0001765 ! ion homeostasis [Term] id: MT:0001569 name: circulating bilirubin level namespace: Trait.ontology alt_id: MT:0000200 def: "aberrant concentration in the blood of this yellow heme breakdown product " [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "abnormal bilirubin level" EXACT [] is_a: MT:0000179 ! blood chemistry [Term] id: MT:0001570 name: circulating enzyme level namespace: Trait.ontology alt_id: MT:0000201 def: "aberrant concentration in the blood of any of the proteins that act as catalysts for biological reactions" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] subset: slim_chkn subset: slim_pig synonym: "abnormal blood enzyme level" EXACT [] is_a: MT:0005319 ! enzyme/ coenzyme level is_a: MT:0005416 ! circulating protein level [Term] id: MT:0001573 name: circulating alanine transaminase level namespace: Trait.ontology alt_id: MT:0000204 def: "aberrant concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2-ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal alanine aminotransferase level" EXACT [] synonym: "abnormal alanine transaminase level" EXACT [] synonym: "abnormal ALT level" EXACT [] synonym: "abnormal glutamic-pyruvic transaminase level" EXACT [] is_a: MT:0001570 ! circulating enzyme level [Term] id: MT:0001574 name: oxygen level namespace: Trait.ontology def: "anomalous concentration of this gaseous element, essential for animal and plant life " [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0003948 ! gas homeostasis [Term] id: MT:0001575 name: cyanosis namespace: Trait.ontology def: "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [J:60159, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000179 ! blood chemistry is_a: MT:0001574 ! oxygen level [Term] id: MT:0001577 name: anemia namespace: Trait.ontology def: "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [J:53370, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002124 ! red blood cell [Term] id: MT:0001584 name: platelet storage pool deficiency namespace: Trait.ontology alt_id: MT:0000212 def: "a blood coagulation disorder in which there is a decrease or lack of platelet dense bodies" [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "platelet storage pooling deficiency" EXACT [] is_a: MT:0001545 ! hematopoietic system physiology is_a: MT:0002551 ! blood coagulation [Term] id: MT:0001585 name: hemolytic anemia namespace: Trait.ontology alt_id: MT:0000213 def: "an anemic condition resulting from an increased rate of erythrocyte destruction" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "increased rate of erythrocyte destruction" EXACT [] is_a: MT:0001577 ! anemia [Term] id: MT:0001586 name: erythrocyte count namespace: Trait.ontology alt_id: MT:0000214 def: "altered number of red blood cells per volume in the bloodstream" [J:53370] synonym: "abnormal erythrocyte count" EXACT [] synonym: "abnormal RBC count" EXACT [] synonym: "abnormal red blood cell count" EXACT [] synonym: "erythrocyte count abnormalities" EXACT [] is_a: MT:0002124 ! red blood cell [Term] id: MT:0001588 name: hemoglobin namespace: Trait.ontology alt_id: MT:0000224 def: "defects in the levels or the function of the oxygen-carrying protein of erythrocytes" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "haemoglobin abnormalities" EXACT [] synonym: "haemoglobin defects" EXACT [] synonym: "hemoglobin defects" EXACT [] is_a: MT:0002124 ! red blood cell [Term] id: MT:0001589 name: mean corpuscular hemoglobin namespace: Trait.ontology alt_id: MT:0000225 alt_id: MT:0002595 def: "anomalies in the average levels of hemoglobin contained in an erythrocyte" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal MCH" EXACT [] synonym: "mean corpuscular hemoglobin" EXACT [] is_a: MT:0001588 ! hemoglobin [Term] id: MT:0001598 name: blood viscosity namespace: Trait.ontology alt_id: MT:0000234 def: "resistance to flow of the blood through the vessels" [ISBN:0-683-40008-8 "Stedman's Medical Dictionary, 27th edition"] is_a: MT:0002128 ! blood circulation [Term] id: MT:0001599 name: blood volume namespace: Trait.ontology alt_id: MT:0000235 def: "amount of space occupied by the blood in the vessels" [ISBN:0-683-40008-8 "Stedman's Medical Dictionary, 27th edition"] is_a: MT:0002128 ! blood circulation [Term] id: MT:0001601 name: myelopoiesis namespace: Trait.ontology alt_id: MT:0000169 def: "atypical process of bone marrow cell formation and/or bone marrow-derived blood cells" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8, tc:Teresa Chu_Mouse Genome Informatics Curator] subset: slim_pig synonym: "myelopoiesis abnormalities" EXACT [] is_a: MT:0005460 ! leukopoiesis [Term] id: MT:0001613 name: vasodilation namespace: Trait.ontology alt_id: MT:0000251 def: "widening of the lumen of the blood vessels" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] is_a: MT:0000249 ! blood vessel physiology [Term] id: MT:0001614 name: blood vessel morphology namespace: Trait.ontology alt_id: MT:0000252 alt_id: MT:0001611 alt_id: MT:0002125 def: "any measurable or observable characteristic related to the shape, structure, color or pattern of the network of tubes that carries blood through the body" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] synonym: "vascular morphology" RELATED [] xref: MP:0001614 is_a: MT:0002127 ! cardiovascular system morphology [Term] id: MT:0001619 name: blood vessel permeability namespace: Trait.ontology alt_id: MT:0000258 def: "anomaly in the ability of the blood vessels to permit the passage of substances such as fluid, heat, or gases" [ISBN:0-683-40008-8 "Stedman's Medical Dictionary, 27th edition"] synonym: "vascular permeability" RELATED [] is_a: MT:0000249 ! blood vessel physiology [Term] id: MT:0001625 name: heart cell size namespace: Trait.ontology def: "the physical dimensions, proportions, magnitude, or extent of the cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] synonym: "cardiac cell size" EXACT [] relationship: part_of MT:0005406 ! heart size [Term] id: MT:0001627 name: cardiac output namespace: Trait.ontology alt_id: MT:0000303 def: "blood volume pumped by each ventricle per minute (stroke volume x heart rate)" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] is_a: MT:0002128 ! blood circulation [Term] id: MT:0001629 name: heart rate namespace: Trait.ontology alt_id: MT:0000305 def: "resting heart beats per unit of time" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] is_a: MT:0001544 ! cardiovascular system physiology [Term] id: MT:0001636 name: heartbeat regularity namespace: Trait.ontology def: "timing of heart contraction" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] synonym: "heart rhythm" EXACT [] is_a: MT:0004085 ! heartbeat [Term] id: MT:0001648 name: apoptosis namespace: Trait.ontology def: "excessive or absent cell death in a particular tissue or cell type" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, J:25248, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] xref: GO:0006915 is_a: MT:0000313 ! cell death [Term] id: MT:0001649 name: symphysis menti namespace: Trait.ontology alt_id: MT:0000096 def: "malformed fibrocartilagenous union of the two halves of the mandible (embryonic stages)" [J:17489, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal symphysis menti" EXACT [] is_a: MT:0000458 ! mandible morphology [Term] id: MT:0001651 name: necrosis namespace: Trait.ontology def: "pathological death of cells or a portion of a tissue or organ; usually due to irreversible damage" [J:23061] is_a: MT:0000313 ! cell death [Term] id: MT:0001652 name: colonic necrosis namespace: Trait.ontology def: "pathologic death of cells within, or a portion of, the colon" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] is_a: MT:0000495 ! colon morphology [Term] id: MT:0001653 name: gastric necrosis namespace: Trait.ontology def: "pathologic death of cells within, or a portion of, the stomach" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] is_a: MT:0000470 ! stomach morphology [Term] id: MT:0001654 name: hepatic necrosis namespace: Trait.ontology def: "pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "liver necrosis" EXACT [] is_a: MT:0000598 ! liver morphology [Term] id: MT:0001655 name: multifocal hepatic necrosis namespace: Trait.ontology def: "multiple localized areas of pathologic death of cells within, or portions of, the liver" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] is_a: MT:0001654 ! hepatic necrosis [Term] id: MT:0001656 name: focal hepatic necrosis namespace: Trait.ontology def: "a localized area of pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] is_a: MT:0001654 ! hepatic necrosis [Term] id: MT:0001657 name: induced morbidity/mortality namespace: Trait.ontology def: "differences from the expected diseased state or death caused by an external intervention" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] is_a: MT:0005372 ! life span/aging trait [Term] id: MT:0001658 name: mortality induced by gamma-irradiation namespace: Trait.ontology def: "greater sensitivity to doses of ionizing radiation" [J:51834] is_a: MT:0003010 ! mortality induced by ionizing radiation [Term] id: MT:0001661 name: life span namespace: Trait.ontology def: "persistence of life for a longer period than is normal for an organism" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] subset: slim_pig synonym: "extended lifespan" EXACT [] is_a: MT:0005372 ! life span/aging trait [Term] id: MT:0001663 name: digestive system physiology namespace: Trait.ontology alt_id: MT:0002142 def: "altered function of the organ system that converts ingested food to nutrients and energy" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "digestive system physiology abnormalities" EXACT [] synonym: "digestive system: functional anomalies" EXACT [] xref: MGI:2173602 is_a: MT:0005381 ! digestive/alimentary trait [Term] id: MT:0001664 name: digestion namespace: Trait.ontology def: "altered ability of the mechanical, chemical, and enzymatic processes of the body to convert ingested food into material suitable for assimilation for synthesis of tissues or liberation of energy " [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal digestive function" EXACT [] is_a: MT:0001663 ! digestive system physiology [Term] id: MT:0001665 name: chronic diarrhea namespace: Trait.ontology def: "prolonged diarrhea" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0005036 ! diarrhea [Term] id: MT:0001666 name: nutrient absorption namespace: Trait.ontology def: "anomalous ability of the body to take in constituents of food necessary for normal physiologic function" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001663 ! digestive system physiology [Term] id: MT:0001667 name: carbohydrate absorption namespace: Trait.ontology def: "anomalous ability of the body to take in substances composed of carbon, hydrogen, and oxygen according to the general formula Cn(H2O)n; sugars and starches are examples" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] is_a: MT:0001666 ! nutrient absorption [Term] id: MT:0001668 name: fructose absorption namespace: Trait.ontology def: "anomalous ability of the body to take in this 5-carbon sugar" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] is_a: MT:0001667 ! carbohydrate absorption [Term] id: MT:0001669 name: glucose absorption namespace: Trait.ontology def: "anomalous ability of the body to take in this major monosaccharide, a 6-carbon sugar" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] is_a: MT:0001667 ! carbohydrate absorption [Term] id: MT:0001670 name: mineral absorption namespace: Trait.ontology def: "anomalous ability of the body to take in any inorganic substance that has importance in body functions" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001666 ! nutrient absorption [Term] id: MT:0001671 name: vitamin absorption namespace: Trait.ontology def: "anomalous ability to take in any of a group of organic substances, present in food, that are essential to normal metabolism" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001666 ! nutrient absorption [Term] id: MT:0001672 name: embryogenesis/ development namespace: Trait.ontology def: "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "embryogenesis/ development abnormalities" EXACT [] xref: GO:0007275 is_a: MT:0005380 ! embryogenesis trait [Term] id: MT:0001674 name: triploblastic development namespace: Trait.ontology def: "abnormal development of the three primary germ layers" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8, tc:Teresa Chu_Mouse Genome Informatics Curator] is_a: MT:0002084 ! developmental patterning [Term] id: MT:0001675 name: ectoderm development namespace: Trait.ontology def: "failure or abnormality in the formation of the ectoderm during gastrulation" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] xref: GO:0001705 is_a: MT:0001674 ! triploblastic development [Term] id: MT:0001676 name: apical ectodermal ridge namespace: Trait.ontology def: "malformation of the multilayered ectodermal region at the tip of a limb bud necessary for the proper development of the underlying mesenchyme" [tc:Teresa Chu_Mouse Genome Informatics Curator] is_a: MT:0001675 ! ectoderm development [Term] id: MT:0001680 name: mesoderm development namespace: Trait.ontology alt_id: MT:0001681 def: "failure or abnormality in the formation of the mesoderm during gastrulation" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] synonym: "abnormal mesoderm differentiation" EXACT [] xref: GO:0001707 is_a: MT:0001674 ! triploblastic development [Term] id: MT:0001684 name: axial mesoderm development namespace: Trait.ontology def: "malformed middle primary germ layer" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, J:51834, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001680 ! mesoderm development [Term] id: MT:0001685 name: endoderm development namespace: Trait.ontology alt_id: MT:0001686 def: "failure or abnormality in the formation of the endoderm during gastrulation" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] synonym: "abnormal endoderm differentiation" EXACT [] xref: GO:0001706 is_a: MT:0001674 ! triploblastic development [Term] id: MT:0001688 name: somite development namespace: Trait.ontology def: "anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal metablastic segment development" EXACT [] is_a: MT:0002085 ! embryonic tissue morphology [Term] id: MT:0001690 name: onset of somite differentiation namespace: Trait.ontology def: "disorganized or absent somite tissue or somite pattern in development" [J:25248] is_a: MT:0001688 ! somite development [Term] id: MT:0001691 name: somite shape namespace: Trait.ontology def: "atypical characteristic surface configuration of a segmental mass along the notochord of the developing embryo" [J:37888] synonym: "irregular somite shape" EXACT [] is_a: MT:0001688 ! somite development [Term] id: MT:0001695 name: gastrulation namespace: Trait.ontology def: "anomalous development and invagination of the embryonic germ layers" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] xref: GO:0007669 is_a: MT:0002084 ! developmental patterning [Term] id: MT:0001697 name: embryo size namespace: Trait.ontology def: "anomalous proportions of embryo compared to littermates (sensu Mus: up to E14, or the completion of organogenesis)" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] is_a: MT:0001672 ! embryogenesis/ development is_a: MT:0002088 ! embryonic growth/weight/body size [Term] id: MT:0001700 name: embryo turning namespace: Trait.ontology def: "atypical axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (Mus:E8.5-E9.5) such that the curvature of the entire trunk region is reversed and the neural ectoderm moves to the convex region and the midgut region becomes located in the concave region" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, The Atlas of Mouse Development:ISBN 0-12-402035-6] synonym: "Abnormal Turning of Embryo" EXACT [] xref: GO:0007669 is_a: MT:0001695 ! gastrulation [Term] id: MT:0001704 name: dorsal-ventral axis patterning namespace: Trait.ontology def: "anomaly in the development or formation of the axis that runs from the front to the back surface of the body" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] synonym: "abnormal back-front patterning" EXACT [] is_a: MT:0002084 ! developmental patterning [Term] id: MT:0001705 name: proximal-distal axis patterning namespace: Trait.ontology def: "anomaly in the formation or development of a body structure, often a limb, in relation to the structure's proximity to the trunk or point of origin" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] is_a: MT:0002084 ! developmental patterning [Term] id: MT:0001706 name: left-right axis patterning namespace: Trait.ontology def: "anomaly in the formation or development of the body or a specific organ of the body in relation to the left and right sides of the body or organ" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] is_a: MT:0002084 ! developmental patterning [Term] id: MT:0001710 name: amniotic fold morphology namespace: Trait.ontology def: "failure of amnion to form involutions" [J:40594] synonym: "absence of amniotic folds" EXACT [] is_a: MT:0005029 ! amnion morphology [Term] id: MT:0001711 name: placenta morphology namespace: Trait.ontology def: "any anomaly in the size or shape of the organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0002086 ! extraembryonic tissue morphology [Term] id: MT:0001712 name: placental development namespace: Trait.ontology def: "malformed or incomplete differentiation of the organ of metabolic exchange between the fetus and mother" [J:61790, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001711 ! placenta morphology [Term] id: MT:0001713 name: trophoblast giant cell number namespace: Trait.ontology def: "fewer than normal number of cells of the extraembryonic cell layer that contributes to the placenta" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, J:23171, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0005033 ! trophoblast giant cell morphology [Term] id: MT:0001716 name: placental labyrinth morphology namespace: Trait.ontology def: "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171] synonym: "abnormal labyrinth layer" RELATED [] is_a: MT:0001711 ! placenta morphology [Term] id: MT:0001718 name: yolk sac morphology namespace: Trait.ontology def: "malformed extraembryonic tissue which contributes to hematopoietic circulation" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, J:12623, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal exocoelomic cavity" EXACT [] is_a: MT:0002086 ! extraembryonic tissue morphology [Term] id: MT:0001721 name: blood island morphology namespace: Trait.ontology def: "missing pools of blood in the yolk sac" [J:12623] synonym: "absence of blood islands" EXACT [] is_a: MT:0001718 ! yolk sac morphology [Term] id: MT:0001722 name: yolk sac color namespace: Trait.ontology def: "bloodless yolk sac" [J:62571] is_a: MT:0001718 ! yolk sac morphology [Term] id: MT:0001723 name: yolk sac vascular plexus morphology namespace: Trait.ontology def: "anomaly in the pattern of the primary (honeycomb-like) vasculature of the yolk sac prior to remodeling into a mature vascular network" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0003229 ! vitelline vascular morphology [Term] id: MT:0001724 name: extraembryonic endoderm formation namespace: Trait.ontology def: "malformation of the endoderm of the extraembryonic tissue that appears prior to gastrulation and performs critical functions during embryogenesis including nutrient uptake and transport from the mother to the embryo" [J:62628] synonym: "abnormal visceral endoderm development" EXACT [] is_a: MT:0002086 ! extraembryonic tissue morphology [Term] id: MT:0001725 name: umbilical cord morphology namespace: Trait.ontology def: "malformed connective stalk between the fetus and the placenta" [J:40203, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002086 ! extraembryonic tissue morphology [Term] id: MT:0001726 name: allantois morphology namespace: Trait.ontology def: "malformed fetal membrane which contributes to the formation of the umbilical cord and placental blood vessels" [J:12622, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002086 ! extraembryonic tissue morphology [Term] id: MT:0001727 name: embryo implantation namespace: Trait.ontology def: "failure or reduced ability of the blastocyst to attach to the endometrium of the uterus due to defects in the embryo" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001672 ! embryogenesis/ development [Term] id: MT:0001731 name: postnatal growth rate namespace: Trait.ontology def: "anomaly in reaching a developmental stage or stages after birth" [il:Ira Lu_Mouse Genome Informatics Curator] subset: slim_cattle subset: slim_chkn subset: slim_pig is_a: MT:0002089 ! postnatal growth/weight/body size [Term] id: MT:0001739 name: adrenal secretion namespace: Trait.ontology def: "altered ability of the surparenal gland to secrete hormones " [hdene:Howard Dene_Mouse Genome Informatics Curator] is_a: MT:0002909 ! adrenal gland physiology [Term] id: MT:0001740 name: adrenal epinephrine secretion namespace: Trait.ontology def: "inability of adrenal gland to deliver epinephrine into the blood stream" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, J:54931, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "failure of adrenaline secretion" EXACT [] synonym: "failure of epinephrine secretion" EXACT [] is_a: MT:0001739 ! adrenal secretion [Term] id: MT:0001744 name: corticosterone secretion namespace: Trait.ontology def: "increased release of this adrenocortical steroid that induces glycogen deposition and regulates sodium conservation and potassium secretion" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001739 ! adrenal secretion [Term] id: MT:0001746 name: pituitary secretion namespace: Trait.ontology def: "altered ability of the pituitary to release its products" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] is_a: MT:0005646 ! pituitary gland physiology [Term] id: MT:0001747 name: adrenocorticotropin secretion namespace: Trait.ontology def: "increased release of this pituitary hormone from the pituitary gland that stimulates the secretion of adrenal cortical steroids and induces growth of the adrenal cortex" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "hypersecretion of ACTH" EXACT [] is_a: MT:0001746 ! pituitary secretion [Term] id: MT:0001752 name: hypothalamus secretion namespace: Trait.ontology def: "altered ability of the hypothalamus to release its contents" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] is_a: MT:0005645 ! hypothalamus physiology [Term] id: MT:0001753 name: corticotropin-releasing hormone secretion namespace: Trait.ontology def: "excessive release of this factor, which normally stimulates the pituitary to release adrenocorticotropic hormone, from the hypothalamus" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "hypersecretion of CRH" EXACT [] is_a: MT:0001752 ! hypothalamus secretion [Term] id: MT:0001754 name: circulating corticotropin-releasing hormone level namespace: Trait.ontology def: "higher than average amount of CRH in blood; CRH is normally released by the hypothalamus and stimulates the release of corticotropin by the anterior pituitary gland " [J:57315] synonym: "elevated serum levels of corticotropin-releasing hormone" EXACT [] synonym: "elevated serum levels of CRH" EXACT [] is_a: MT:0005418 ! circulating hormone level [Term] id: MT:0001756 name: urination namespace: Trait.ontology def: "anomaly in the production and excretion of urine" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] synonym: "abnormal micturition" EXACT [] is_a: MT:0005502 ! urinary system physiology [Term] id: MT:0001757 name: urine chemistry namespace: Trait.ontology alt_id: MT:0005427 def: "any anomaly in the examination of urine by chemical, physical, or microscopic means" [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal urinalysis" EXACT [] is_a: MT:0005428 ! clinical chemistry is_a: MT:0005502 ! urinary system physiology [Term] id: MT:0001758 name: urine glucose level namespace: Trait.ontology def: "any change in the level of excretion of glucose in the urine" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0001757 ! urine chemistry [Term] id: MT:0001760 name: urine enzyme level namespace: Trait.ontology def: "any change in the level of excretion of enzymes in the urine" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0001757 ! urine chemistry [Term] id: MT:0001761 name: urination pattern namespace: Trait.ontology def: "increased or decreased frequency of urination" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0001756 ! urination [Term] id: MT:0001762 name: polyuria namespace: Trait.ontology def: "increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, smb:Susan M. Bello_Mouse Genome Informatics Curator] synonym: "diuresis" EXACT [] synonym: "frequent urination" EXACT [] synonym: "increased urine output" EXACT [] is_a: MT:0005555 ! kidney excretion [Term] id: MT:0001764 name: homeostasis namespace: Trait.ontology def: "anomaly in the state of equilibrium in the body with respect to various functions and to chemical composition of the fluids and tissues" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] subset: slim_cattle subset: slim_chkn subset: slim_pig synonym: "homeostasis abnormalities" EXACT [] is_a: MT:0005376 ! homeostasis/metabolism trait [Term] id: MT:0001765 name: ion homeostasis namespace: Trait.ontology def: "anomaly in the state of equilibrium in the body with respect to charged molecules in the fluids and tissues" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] is_a: MT:0001764 ! homeostasis [Term] id: MT:0001770 name: iron level namespace: Trait.ontology alt_id: MT:0000209 alt_id: MT:0001581 def: "anomalous concentrations of this metallic element that normally occurs in the heme of hemoglobin, myoglobin, transferrin, ferritin, and iron-containing porphyrins; it is an essential component of enzymes such as catalase, peroxidase, and various cytochromes" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000192 ! mineral level is_a: MT:0005637 ! iron homeostasis [Term] id: MT:0001771 name: circulating magnesium level namespace: Trait.ontology def: "anomalous blood concentration of this bioelement" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal magnesium level" EXACT [] is_a: MT:0000179 ! blood chemistry is_a: MT:0001765 ! ion homeostasis [Term] id: MT:0001775 name: selenium level namespace: Trait.ontology def: "anomalous concentration of this essential trace element, required for glutathione peroxidase and other enzymes" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000192 ! mineral level [Term] id: MT:0001776 name: circulating sodium level namespace: Trait.ontology def: "anomalous concentration in the blood of this metallic element, the most plentiful extracellular ion in the body and the principal determinant of extracellular fluid volume" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal sodium level" EXACT [] is_a: MT:0000179 ! blood chemistry is_a: MT:0001765 ! ion homeostasis [Term] id: MT:0001777 name: body temperature regulation namespace: Trait.ontology def: "anomalous control of the body's heat" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "abnormal temperature regulation" EXACT [] synonym: "abnormal thermoregulation" EXACT [] is_a: MT:0005535 ! body temperature [Term] id: MT:0001778 name: brown fat amount namespace: Trait.ontology alt_id: MT:0000004 synonym: "abnormal brown fat" EXACT [] is_a: MT:0002971 ! brown fat morphology is_a: MT:0005452 ! body fat amount [Term] id: MT:0001781 name: white fat amount namespace: Trait.ontology alt_id: MT:0000007 subset: slim_cattle subset: slim_pig synonym: "abnormal white fat" EXACT [] is_a: MT:0002970 ! white fat morphology is_a: MT:0005452 ! body fat amount [Term] id: MT:0001784 name: fluid regulation namespace: Trait.ontology def: "anomalous control of intracellular and/or extracellular fluid" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] subset: slim_cattle subset: slim_chkn is_a: MT:0001764 ! homeostasis [Term] id: MT:0001785 name: edema namespace: Trait.ontology alt_id: MT:0001338 def: "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [J:54065, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] subset: slim_cattle subset: slim_chkn synonym: "oedema" EXACT [] is_a: MT:0001784 ! fluid regulation [Term] id: MT:0001786 name: skin edema namespace: Trait.ontology alt_id: MT:0001207 def: "accumulation of an excessive amount of fluid in the skin" [J:65039] is_a: MT:0001191 ! skin condition is_a: MT:0001785 ! edema [Term] id: MT:0001787 name: pericardial edema* namespace: Trait.ontology alt_id: MT:0000290 def: "accumulation of watery fluid in the pericardial sac of the heart" [J:52597] subset: slim_chkn synonym: "fluid in the heart sac" EXACT [] synonym: "pericardial edema" EXACT [] is_a: MT:0001785 ! edema [Term] id: MT:0001788 name: periorbital edema namespace: Trait.ontology alt_id: MT:0001339 def: "accumulation of an excessive amount of fluid in the area around the orbit " [J:60896, tc:Teresa Chu_Mouse Genome Informatics Curator] is_a: MT:0001785 ! edema is_a: MT:0005246 ! orbit morphology [Term] id: MT:0001790 name: immune system physiology namespace: Trait.ontology alt_id: MT:0001789 def: "deviation from the normal function of the immune system" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] comment: pslim term (new) subset: slim_cattle subset: slim_chkn subset: slim_pig synonym: "Immune System" EXACT [] synonym: "immune system/response abnormalities" EXACT [] synonym: "immune system: response/ function abnormalities" EXACT [] xref: GO:0006955 is_a: MT:0005387 ! immune system trait [Term] id: MT:0001791 name: immunodeficiency namespace: Trait.ontology def: "defective immune response; can be primary due to defect in immune system or secondary due to disease" [J:61201, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001790 ! immune system physiology [Term] id: MT:0001793 name: susceptibility to infection namespace: Trait.ontology alt_id: MT:0002548 def: "a change in the likelihood that an organism will develop ill effects from a pathogenic invasion or from components of or toxins produced by pathogens" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] subset: slim_cattle subset: slim_pig synonym: "altered resistance to infection" EXACT [] is_a: MT:0005025 ! response to infection [Term] id: MT:0001798 name: macrophage phagocytosis namespace: Trait.ontology def: "reduced ability of these phagocytic cells to internalize particulate matter" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] synonym: "decreased macrophage phagocytosis" EXACT [] is_a: MT:0002451 ! macrophage physiology is_a: MT:0002488 ! phagocytic cell physiology [Term] id: MT:0001800 name: humoral immune response namespace: Trait.ontology def: "abnormal immune function mediated by antibodies" [Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] subset: slim_chkn subset: slim_pig synonym: "antibody response" EXACT [] synonym: "antibody-mediated immune response abnormalities" EXACT [] synonym: "humoral immune response dysfunction" EXACT [] is_a: MT:0001790 ! immune system physiology [Term] id: MT:0001804 name: complement protein physiology namespace: Trait.ontology def: "functional anomaly of any of the complement proteins" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "complement protein dysfunction" EXACT [] is_a: MT:0002468 ! complement physiology [Term] id: MT:0001805 name: circulating IgG level namespace: Trait.ontology alt_id: MT:0001815 def: "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] subset: slim_pig synonym: "Decreased Serum Level of Immunoglobulin G" EXACT [] is_a: MT:0002490 ! circulating immunoglobulin concentration [Term] id: MT:0001806 name: circulating IgM level namespace: Trait.ontology alt_id: MT:0001816 def: "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "Decreased Serum Level of Immunoglobulin M" EXACT [] is_a: MT:0002490 ! circulating immunoglobulin concentration [Term] id: MT:0001807 name: circulating IgA level namespace: Trait.ontology def: "less than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] is_a: MT:0002490 ! circulating immunoglobulin concentration [Term] id: MT:0001819 name: immune cell physiology namespace: Trait.ontology def: "abnormal function of the cells of the immune system" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] subset: slim_pig synonym: "immune cell dysfunction" EXACT [] is_a: MT:0001790 ! immune system physiology [Term] id: MT:0001824 name: thymic involution namespace: Trait.ontology alt_id: MT:0000710 def: "premature or late decline in thymic function normally associated with advancing age" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, smb:Susan M. Bello_Mouse Genome Informatics Curator] synonym: "involuted thymus" EXACT [] is_a: MT:0003763 ! thymus physiology [Term] id: MT:0001828 name: T cell activation namespace: Trait.ontology def: "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] comment: this process requires recognition of a foreign peptide fragment bound to self-MHC and the simultaneous delivery of a co-stimulatory signal by an antigen presenting cell; it results in the clonal expansion of naive T cells and their differentiation into armed effector cells synonym: "abnormal T-cell activation" EXACT [] is_a: MT:0002444 ! T cell physiology [Term] id: MT:0001830 name: activated T cell number namespace: Trait.ontology alt_id: MT:0000331 def: "reduced numbers of effector T cells" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "decreased activated T cell number" EXACT [] synonym: "decreased activated T-cell number" EXACT [] is_a: MT:0001828 ! T cell activation [Term] id: MT:0001831 name: T cell immunodeficiency namespace: Trait.ontology alt_id: MT:0002537 def: "defective immune response due to defective T-lymphocyte response" [J:33796, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "T-cell deficiency" EXACT [] synonym: "T-cell immunodeficiency" EXACT [] is_a: MT:0001791 ! immunodeficiency [Term] id: MT:0001835 name: antigen presentation namespace: Trait.ontology def: "aberration in the process by which peptide is presented to lymphocytes in a form they can recognize " [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] comment: this process requires ingestion and partial digestion of the antigen followed by presentation of the digested antigen at the cell surface synonym: "antigen presentation dysfunction" EXACT [] is_a: MT:0001790 ! immune system physiology [Term] id: MT:0001836 name: antigen presentation via MHC class I namespace: Trait.ontology def: "anomaly in the process by which peptide, bound to major histocompatibility complex class I, is presented to lymphocytes at the surface of antigen presenting cells" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "inability to present cytosolic antigens to Class-I restricted cytotoxic T cells" EXACT [] is_a: MT:0001835 ! antigen presentation [Term] id: MT:0001837 name: assembly of class I molecules namespace: Trait.ontology def: "impaired production of major histocompatibility complex class I molecules" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] is_a: MT:0001836 ! antigen presentation via MHC class I [Term] id: MT:0001838 name: intracellular transport of class I molecules namespace: Trait.ontology def: "impaired ability to move major histocompatibility complex class I molecules to the cell surface" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] is_a: MT:0001836 ! antigen presentation via MHC class I [Term] id: MT:0001839 name: level of surface class I molecules namespace: Trait.ontology def: "deviation from the normal concentration of major histocompatibility complex class I molecules expressed at the cell surface " [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] comment: almost all nucleated blood cells express class I molecules on their surfaces (red blood cells, being non-nucleated, do not); MHC class I molecules present peptides from pathogens in the cytosol (often viruses) to CD8 T cells is_a: MT:0001836 ! antigen presentation via MHC class I [Term] id: MT:0001844 name: autoimmune response namespace: Trait.ontology def: "condition in which cells and/or antibodies arise from and are directed against one's own tissues " [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0005005 ! self tolerance [Term] id: MT:0001845 name: inflammatory response namespace: Trait.ontology def: "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0] subset: slim_pig synonym: "inflammation" EXACT [] synonym: "inflammatory response" EXACT [] is_a: MT:0001790 ! immune system physiology [Term] id: MT:0001846 name: tissue specific inflammatory response namespace: Trait.ontology def: "greater than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] subset: slim_pig is_a: MT:0001845 ! inflammatory response [Term] id: MT:0001847 name: brain inflammation namespace: Trait.ontology def: "local accumulation of fluid, plasma proteins, and leukocytes in the brain" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] synonym: "encephalitis" EXACT [] is_a: MT:0006082 ! CNS inflammation [Term] id: MT:0001848 name: choroid inflammation namespace: Trait.ontology def: "local accumulation of fluid, plasma proteins, and leukocytes in the thin, highly vascularized membrane covering most of the posterior of the eye between the retina and the sclera" [Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7, MeSH:National Library of Medicine_Medical Subject Headings] synonym: "choroiditis" EXACT [] is_a: MT:0001851 ! eye inflammation [Term] id: MT:0001849 name: susceptibility to ear inflammation namespace: Trait.ontology def: "prevalence of or sensitivity to local accumulation of fluid, plasma proteins and leukocytes in the ear" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] is_a: MT:0001846 ! tissue specific inflammatory response is_a: MT:0005377 ! hearing/vestibular/ear trait [Term] id: MT:0001850 name: susceptibility to middle ear inflammation namespace: Trait.ontology alt_id: MT:0000050 def: "prevalence of or sensitivity to local accumulation of fluid, plasma proteins and leukocytes in the middle ear" [J:60896, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001849 ! susceptibility to ear inflammation [Term] id: MT:0001851 name: eye inflammation namespace: Trait.ontology def: "local accumulation of fluid, plasma proteins, and leukocytes in the eye" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] is_a: MT:0001846 ! tissue specific inflammatory response is_a: MT:0005253 ! eye physiology [Term] id: MT:0001852 name: conjunctivitis namespace: Trait.ontology alt_id: MT:0001311 def: "inflammation of the mucous membrane that lines the inner surface of the eyelids and the front of the eyeball" [J:60896, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001310 ! conjunctiva morphology is_a: MT:0001851 ! eye inflammation [Term] id: MT:0001853 name: heart inflammation* namespace: Trait.ontology def: "local accumulation of fluid, plasma proteins, and leukocytes in the heart" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] synonym: "cardiac inflammation" EXACT [] synonym: "carditis" EXACT [] is_a: MT:0001846 ! tissue specific inflammatory response [Term] id: MT:0001855 name: atrial thrombosis namespace: Trait.ontology def: "formation or presence of a thrombus in the atria of the heart " [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] is_a: MT:0005048 ! thrombosis [Term] id: MT:0001858 name: intestinal inflammation namespace: Trait.ontology def: "local accumulation of fluid, plasma proteins, and leukocytes in the intestine" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] synonym: "g.i. inflammation" EXACT [] synonym: "gastrointestinal inflammation" EXACT [] synonym: "inflammation of intestine" EXACT [] is_a: MT:0001663 ! digestive system physiology is_a: MT:0001846 ! tissue specific inflammatory response [Term] id: MT:0001859 name: kidney inflammation namespace: Trait.ontology def: "local accumulation of fluid, plasma proteins, and leukocytes in the kidney" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] synonym: "nephritis" EXACT [] synonym: "renal inflammation" EXACT [] is_a: MT:0001846 ! tissue specific inflammatory response is_a: MT:0002135 ! kidney morphology [Term] id: MT:0001860 name: liver inflammation namespace: Trait.ontology def: "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] synonym: "hepatic inflammation" EXACT [] synonym: "hepatitis" EXACT [] is_a: MT:0000609 ! liver physiology is_a: MT:0001846 ! tissue specific inflammatory response [Term] id: MT:0001861 name: lung inflammation namespace: Trait.ontology def: "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] synonym: "pneumonia" EXACT [] synonym: "pulmonary inflammation" EXACT [] is_a: MT:0002405 ! respiratory system inflammation [Term] id: MT:0001862 name: interstitial pneumonia namespace: Trait.ontology def: "disorder of the lower respiratory tract, primarily affecting the alveolar wall, but may also involve the small airways and blood vessels of the lung parenchyma; this is usually inflammatory in nature" [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "interstitial pneumonitis" EXACT [] is_a: MT:0001861 ! lung inflammation [Term] id: MT:0001863 name: vascular inflammation* namespace: Trait.ontology def: "local accumulation of fluid, plasma proteins, and leukocytes in a blood vessel" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] comment: this is an abnormal phenotype so shouldn't be here is_a: MT:0001846 ! tissue specific inflammatory response [Term] id: MT:0001865 name: striated muscle inflammation namespace: Trait.ontology def: "local accumulation of fluid, plasma proteins, and leukocytes in the striated muscle" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] is_a: MT:0001846 ! tissue specific inflammatory response is_a: MT:0002106 ! muscle physiology [Term] id: MT:0001866 name: nasal inflammation namespace: Trait.ontology def: "local accumulation of fluid, plasma proteins, and leukocytes in the proximal portion of the respiratory passages" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] subset: slim_pig is_a: MT:0002405 ! respiratory system inflammation [Term] id: MT:0001867 name: rhinitis namespace: Trait.ontology alt_id: MT:0001113 def: "inflammation of the mucous membrane of the nose" [J:60896, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8, tc:Teresa Chu_Mouse Genome Informatics Curator] subset: slim_pig synonym: "nasal catarrh" EXACT [] is_a: MT:0001866 ! nasal inflammation is_a: MT:0002238 ! nasal mucosa morphology [Term] id: MT:0001868 name: ovary inflammation namespace: Trait.ontology def: "local accumulation of fluid, plasma proteins, and leukocytes in the ovary" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] synonym: "oophoritis" EXACT [] synonym: "ovarian inflammation" EXACT [] is_a: MT:0002254 ! reproductive system inflammation is_a: MT:0003699 ! female reproductive system physiology [Term] id: MT:0001869 name: pancreas inflammation namespace: Trait.ontology def: "local accumulation of fluid, plasma proteins, and leukocytes in the pancreas " [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] synonym: "pancreatic inflammation" EXACT [] synonym: "pancreatitis" EXACT [] is_a: MT:0001846 ! tissue specific inflammatory response is_a: MT:0002693 ! pancreas physiology [Term] id: MT:0001870 name: salivary gland inflammation namespace: Trait.ontology alt_id: MT:0000625 alt_id: MT:0000626 alt_id: MT:001871 def: "local accumulation of fluid, plasma proteins, and leukocytes in the salivary gland" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] synonym: "increased inflammatory response of the salivary glands" EXACT [] synonym: "sialadenitis" EXACT [] synonym: "sialoadenitis" EXACT [] is_a: MT:0001846 ! tissue specific inflammatory response is_a: MT:0005310 ! salivary gland physiology [Term] id: MT:0001872 name: sinus inflammation namespace: Trait.ontology def: "increase in susceptibility of the hollow cavities in bone (usually but not exclusively those in the skull) to allergens and/or pathogens" [J:60896, tc:Teresa Chu_Mouse Genome Informatics Curator] synonym: "sinusitis" EXACT [] is_a: MT:0002405 ! respiratory system inflammation [Term] id: MT:0001873 name: stomach inflammation namespace: Trait.ontology def: "local accumulation of fluid, plasma proteins, and leukocytes in the stomach" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] synonym: "autoimmune gastritis" EXACT [] is_a: MT:0001663 ! digestive system physiology is_a: MT:0001846 ! tissue specific inflammatory response [Term] id: MT:0001874 name: spinous layer cell number namespace: Trait.ontology def: "diffuse hyperplasia of the spinous layer of the skin" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001236 ! spinous layer morphology [Term] id: MT:0001875 name: testis inflammation namespace: Trait.ontology def: "local accumulation of fluid, plasma proteins, and leukocytes in the testis" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] synonym: "orchitis" EXACT [] synonym: "testicular inflammation" EXACT [] is_a: MT:0002254 ! reproductive system inflammation is_a: MT:0003698 ! male reproductive system physiology [Term] id: MT:0001878 name: allergic response namespace: Trait.ontology def: "hypersensitivity caused by exposure to a specific antigen (allergen) resulting in a marked increase in reactivity to that antigen upon subsequent exposure" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002531 ! type I hypersensitivity reaction [Term] id: MT:0001879 name: lymphatic vessel morphology namespace: Trait.ontology alt_id: MT:0000309 alt_id: MT:0001638 alt_id: MT:0001639 def: "malformation of the network of vessels which carries lymph around the body" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8, tc:Teresa Chu_Mouse Genome Informatics Curator] synonym: "lymphatic system abnormalities" EXACT [] is_a: MT:0000685 ! immune system morphology [Term] id: MT:0001881 name: mammary gland physiology namespace: Trait.ontology def: "aberrant function of the milk-secreting gland that lies within the breast" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] subset: slim_cattle subset: slim_pig synonym: "abnormal mammary gland function" EXACT [] synonym: "mammary gland abnormalities" EXACT [] is_a: MT:0002164 ! gland physiology is_a: MT:0003699 ! female reproductive system physiology [Term] id: MT:0001882 name: lactation namespace: Trait.ontology alt_id: MT:0001383 def: "atypical production of milk from the mammary gland" [J:51296] subset: slim_cattle subset: slim_pig synonym: "lactation abnormalities" EXACT [] synonym: "lactation defects" EXACT [] is_a: MT:0001881 ! mammary gland physiology [Term] id: MT:0001883 name: mammary adenocarcinoma namespace: Trait.ontology alt_id: MT:0002011 def: "higher than normal incidence of malignant tumors of the mammary gland" [J:62919] is_a: MT:0002038 ! carcinoma [Term] id: MT:0001884 name: mammary alveoli morphology namespace: Trait.ontology def: "increased size due to increased cellularity of the sac-like structure of the mammary gland that secretes milk after pregnancy" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0000627 ! mammary gland morphology [Term] id: MT:0001885 name: mammary duct morphology namespace: Trait.ontology def: "increased size due to increased cellularity of the tubular structure running from the nipple to the alveoli clusters in the mammary gland" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0000627 ! mammary gland morphology [Term] id: MT:0001890 name: anencephaly namespace: Trait.ontology alt_id: MT:0000915 def: "absence of the bones of the cranial vault and absent or rudimentary cerebral and cerebellar hemispheres, brainstem, and basal ganglia" [J:31571, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000074 ! neurocranium morphology is_a: MT:0000913 ! brain development [Term] id: MT:0001891 name: hydroencephaly namespace: Trait.ontology alt_id: MT:0000916 def: "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [MeSH:National Library of Medicine_Medical Subject Headings, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "hydrocephalus" EXACT [] synonym: "Hydrocephaly" EXACT [] is_a: MT:0000254 ! cerebrospinal fluid volume is_a: MT:0000913 ! brain development is_a: MT:0002200 ! brain ventricle/choroid plexus morphology [Term] id: MT:0001893 name: non-obstructive hydrocephaly namespace: Trait.ontology alt_id: MT:0000918 def: "abnormal cerebrospinal fluid absorption where there is no obstruction to fluid flow in the ventricular system" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "Communicating Hydrocephalus" EXACT [] synonym: "communicating hydrocephaly" EXACT [] is_a: MT:0001891 ! hydroencephaly [Term] id: MT:0001895 name: hippocampus function namespace: Trait.ontology def: "anomalous activity of the deep lying structure of the cerebrum involved with memory storage" [MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0003633 ! nervous system physiology [Term] id: MT:0001898 name: long term depression namespace: Trait.ontology alt_id: MT:0001474 def: "change from the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of neurons" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, Principles of Neural Science:ISBN 0-8385-8034-3] synonym: "abnormal LTD" EXACT [] is_a: MT:0002915 ! synaptic depression [Term] id: MT:0001900 name: synaptic plasticity namespace: Trait.ontology def: "decreased or inability of the nervous system to change its reactivity as a result of successive activations " [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0003633 ! nervous system physiology [Term] id: MT:0001901 name: absence of NMDA -mediated synaptic currents namespace: Trait.ontology def: "absence of a measured amplitude or response to stimulation of NMDA receptors" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] synonym: "absence of NMDA -mediated synaptic currents: CA1 region" EXACT [] is_a: MT:0002888 ! NMDA-mediated synaptic currents [Term] id: MT:0001905 name: dopamine level namespace: Trait.ontology def: "greater or less than the normal concentration of this catecholamine neurotransmitter, derived from tyrosine and the precursor to norepinephrine and epinephrine" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal dopaminergic levels" EXACT [] is_a: MT:0003633 ! nervous system physiology [Term] id: MT:0001907 name: cerebellar function namespace: Trait.ontology def: "anomalous activity of the portion of the brain in the back of the head between the cerebrum and the pons that controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills" [MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0003633 ! nervous system physiology [Term] id: MT:0001908 name: somatosensory cortex function namespace: Trait.ontology def: "anomalous activity of the area of the parietal lobe concerned with receiving general sensations" [MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0001907 ! cerebellar function [Term] id: MT:0001909 name: NMDA receptor mediated synaptic activity in barrel cortex namespace: Trait.ontology def: "lower than normal levels of excitatory synaptic current in the barrel cortex" [J:64064, Principles of Neural Science_3rd edition:ISBN 0-8385-8034-3] is_a: MT:0001908 ! somatosensory cortex function is_a: MT:0002888 ! NMDA-mediated synaptic currents [Term] id: MT:0001911 name: cerebrospinal fluid production namespace: Trait.ontology def: "change in the normal secretion of the fluid that fills the ventricles and other cavities of the brain and spinal cord" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0003633 ! nervous system physiology [Term] id: MT:0001915 name: intracranial hemorrhage namespace: Trait.ontology def: "bleeding within the skull, including hemorrhage into the brain and within the cranial epidural, subdural, and subarachnoid spaces" [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "intracranial bleeding" EXACT [] is_a: MT:0003633 ! nervous system physiology [Term] id: MT:0001916 name: intracerebral hemorrhage namespace: Trait.ontology def: "bleeding within the cerebrum" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "cerebral hemorrhage" EXACT [] synonym: "intracerebral bleeding" EXACT [] is_a: MT:0001915 ! intracranial hemorrhage [Term] id: MT:0001919 name: reproductive system physiology namespace: Trait.ontology def: "anomaly in the function of the organs associated with producing offspring" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] subset: slim_cattle subset: slim_chkn subset: slim_pig synonym: "reproductive system physiology anomalies" EXACT [] is_a: MT:0005389 ! reproductive system trait [Term] id: MT:0001921 name: fertility namespace: Trait.ontology alt_id: MT:0001372 def: "diminished ability to produce live offspring" [J:65030] subset: slim_cattle subset: slim_pig synonym: "decreased fecundity" EXACT [] synonym: "semi-sterile" EXACT [] synonym: "semisterile" EXACT [] is_a: MT:0002161 ! fertility/fecundity [Term] id: MT:0001922 name: male fertility namespace: Trait.ontology def: "reduced ability of male to produce live offspring" [J:61340, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001921 ! fertility is_a: MT:0003698 ! male reproductive system physiology [Term] id: MT:0001923 name: female fertility namespace: Trait.ontology def: "reduced ability of female to produce live offspring" [J:60409, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001921 ! fertility is_a: MT:0003699 ! female reproductive system physiology [Term] id: MT:0001927 name: oestrous cycle (sensu Rodentia) namespace: Trait.ontology def: "failure of or aberrant timing of the sexual cycle of female animals" [J:34193, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] subset: slim_cattle subset: slim_pig synonym: "abnormal estrous cycle" EXACT [] synonym: "abnormal estrus cycle" EXACT [] is_a: MT:0003699 ! female reproductive system physiology [Term] id: MT:0001928 name: ovulation namespace: Trait.ontology def: "aberration in the release of an ovum from a rupturing Graafian follicle, normally regulated by a surge in luteinizing hormone" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] subset: slim_cattle subset: slim_pig is_a: MT:0001927 ! oestrous cycle (sensu Rodentia) is_a: MT:0003375 ! menstrual cycle (sensu H. sapiens) [Term] id: MT:0001929 name: gametogenesis namespace: Trait.ontology def: "defective formation or differentiation of germ cells" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, J:42324, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] subset: slim_cattle subset: slim_chkn subset: slim_pig is_a: MT:0002160 ! reproductive system morphology [Term] id: MT:0001930 name: meiosis namespace: Trait.ontology def: "malfunction in the process of nuclear division that results in gametes with one half the normal number of the original cell" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0001929 ! gametogenesis [Term] id: MT:0001931 name: oogenesis namespace: Trait.ontology def: "atypical formation or failure to form the female germ cells" [J:35782, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001929 ! gametogenesis [Term] id: MT:0001932 name: spermiogenesis namespace: Trait.ontology def: "failure of sperm cells to form or differentiate" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001156 ! spermatogenesis [Term] id: MT:0001933 name: litter size namespace: Trait.ontology def: "deviation from the normal number of live born pups in a litter" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] is_a: MT:0002161 ! fertility/fecundity [Term] id: MT:0001937 name: sexual maturation namespace: Trait.ontology def: "a delay or a block in the development of the sexual organs at a given age" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] subset: slim_cattle subset: slim_chkn subset: slim_pig is_a: MT:0002212 ! secondary sex determination [Term] id: MT:0001938 name: time of sexual maturation namespace: Trait.ontology def: "immaturity of the sexual organs at a given age" [J:61190] synonym: "delayed onset of sexual maturity" EXACT [] synonym: "delayed sexual maturity" EXACT [] is_a: MT:0001937 ! sexual maturation [Term] id: MT:0001939 name: secondary sex reversal namespace: Trait.ontology def: "secondary sexual phenotype is not consistent with the chromosomal sex, i.e., internal and/or external genitalia are inconsistent with chromosomal sex " [llw2:Linda Washburn_Mouse Genome Informatics Curator] is_a: MT:0002212 ! secondary sex determination is_a: MT:0005652 ! sex reversal [Term] id: MT:0001940 name: testicular cell number namespace: Trait.ontology def: "decreased cell number in the testicles" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001148 ! testes size [Term] id: MT:0001942 name: lung volume namespace: Trait.ontology def: "anomaly in the amount of air that the lungs contain at various points of the respiratory cycle" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal lung volume measurements" EXACT [] is_a: MT:0001943 ! respiration [Term] id: MT:0001943 name: respiration namespace: Trait.ontology def: "anomaly in the movement of gases into and out of the lung " [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002133 ! respiratory system physiology [Term] id: MT:0001944 name: pancreas morphology namespace: Trait.ontology def: "malformation of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [il:Ira Lu_Mouse Genome Informatics Curator] synonym: "abnormal pancreas" EXACT [] is_a: MT:0000462 ! digestive system morphology is_a: MT:0002163 ! gland morphology [Term] id: MT:0001945 name: bronchoconstriction namespace: Trait.ontology def: "reduction in the caliber of the bronchus or bronchi" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002314 ! respiratory mechanics [Term] id: MT:0001947 name: mucociliary clearance namespace: Trait.ontology def: "anomaly in the rate of ciliary and secretory activity of the respiratory submucosal glands" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0002314 ! respiratory mechanics [Term] id: MT:0001948 name: vesicoureteral reflux namespace: Trait.ontology def: "the retrograde flow of urine from the bladder into the ureters and kidneys" [J:77653, pvb:Pierre Vanden Borre_Mouse Genome Informatics Curator] synonym: "VUX" EXACT [] is_a: MT:0002136 ! kidney physiology [Term] id: MT:0001949 name: respiratory dead space namespace: Trait.ontology def: "anomaly in the section of the respiratory tract that does not exchange oxygen and carbon dioxide with pulmonary capillary blood" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0002314 ! respiratory mechanics [Term] id: MT:0001950 name: respiratory sounds namespace: Trait.ontology def: "anomalous noises heard over any part of the respiratory tract" [MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0002315 ! respiratory signs/symptoms [Term] id: MT:0001951 name: breathing namespace: Trait.ontology alt_id: MT:0001955 def: "irregular or atypical breathing pattern " [J:17489, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "irregular breathing" EXACT [] is_a: MT:0002315 ! respiratory signs/symptoms [Term] id: MT:0001953 name: respiratory failure namespace: Trait.ontology def: "cessation of or failure to commence breathing" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, J:60159] is_a: MT:0001943 ! respiration [Term] id: MT:0001954 name: respiratory distress namespace: Trait.ontology def: "physical difficulty or inability to breathe" [J:54931, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002315 ! respiratory signs/symptoms [Term] id: MT:0001956 name: breathing depth namespace: Trait.ontology def: "breathing that is shallower and/or slower than normal" [J:64289, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001951 ! breathing [Term] id: MT:0001957 name: apnea namespace: Trait.ontology def: "absence of breathing; sometimes episodic" [J:17384, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "failure to breathe" EXACT [] is_a: MT:0001951 ! breathing [Term] id: MT:0001958 name: emphysema namespace: Trait.ontology def: "lung disease characterized by increased size of terminal bronchioles with destructive changes in their walls and reduction in number" [J:33629, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002133 ! respiratory system physiology [Term] id: MT:0001961 name: reflex namespace: Trait.ontology alt_id: MT:0001476 synonym: "reflexes" EXACT [] is_a: MT:0002067 ! sensory capabilities/reflexes/nociception [Term] id: MT:0001963 name: hearing namespace: Trait.ontology alt_id: MT:0001960 def: "the ability to receive auditory stimuli" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal auditory perception" EXACT [] synonym: "auditory abnormalities" EXACT [] synonym: "auditory defects" EXACT [] xref: GO:0007605 is_a: MT:0002104 ! hearing physiology [Term] id: MT:0001964 name: auditory threshold namespace: Trait.ontology def: "anomalies in the average point at which one may first detect auditory signals at given frequencies" [pvb:Pierre Vanden Borre_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] xref: GO:0007605 is_a: MT:0001963 ! hearing [Term] id: MT:0001968 name: touch/ nociception namespace: Trait.ontology is_a: MT:0002067 ! sensory capabilities/reflexes/nociception is_a: MT:0005392 ! touch/vibrissae trait [Term] id: MT:0001970 name: pain threshold namespace: Trait.ontology is_a: MT:0001968 ! touch/ nociception [Term] id: MT:0001983 name: olfactory system physiology namespace: Trait.ontology alt_id: MT:0001110 alt_id: MT:0001111 def: "abnormal function of the system relating to smell " [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "olfactory abnormalities" EXACT [] synonym: "olfactory defects" EXACT [] synonym: "olfactory system abnormalities" EXACT [] is_a: MT:0005394 ! taste/olfaction trait [Term] id: MT:0001984 name: olfaction namespace: Trait.ontology def: "change in the ability to smell" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001983 ! olfactory system physiology [Term] id: MT:0001985 name: gustatory system physiology namespace: Trait.ontology def: "anomalous perception of taste" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal taste physiology" EXACT [] synonym: "abnormal taste response" EXACT [] is_a: MT:0005394 ! taste/olfaction trait [Term] id: MT:0001986 name: taste sensitivity namespace: Trait.ontology def: "changes in the ability to perceive a particular flavor or suggestion of something imparting a flavor by the chemoreceptors of the gustatory system" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0001985 ! gustatory system physiology [Term] id: MT:0001992 name: vestibuloocular reflex namespace: Trait.ontology alt_id: MT:0001477 is_a: MT:0000353 ! vestibular system physiology is_a: MT:0001961 ! reflex is_a: MT:0005253 ! eye physiology [Term] id: MT:0001993 name: blinking reflex namespace: Trait.ontology alt_id: MT:0001478 is_a: MT:0001961 ! reflex [Term] id: MT:0001995 name: blinking frequency namespace: Trait.ontology alt_id: MT:0001480 is_a: MT:0001993 ! blinking reflex [Term] id: MT:0001999 name: photosensitivity namespace: Trait.ontology alt_id: MT:0001484 def: "alterations in the response to sunlight or UV irradiation, especially sensitivity of the eyes" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "photosensitivity abnormalities" EXACT [] is_a: MT:0002121 ! metabolism is_a: MT:0005253 ! eye physiology [Term] id: MT:0002001 name: blindness namespace: Trait.ontology def: "loss of the sense of sight" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002090 ! vision [Term] id: MT:0002006 name: tumorigenesis namespace: Trait.ontology def: "induction of new growth" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0000001 ! Trait [Term] id: MT:0002009 name: preneoplasia namespace: Trait.ontology def: "state preceding the pathological process resulting in a neoplasm; does not necessarily imply cancerous development" [J:47225] is_a: MT:0002166 ! tumor susceptibility [Term] id: MT:0002012 name: trichofolliculoma namespace: Trait.ontology def: "tumors which contain multiple abortive and/or misaligned hair follicles " [J:51296] is_a: MT:0002019 ! tumor incidence [Term] id: MT:0002013 name: pilomatriculoma namespace: Trait.ontology def: "hair follicle tumor" [J:51296] is_a: MT:0002019 ! tumor incidence [Term] id: MT:0002014 name: papilloma namespace: Trait.ontology def: "benign epithelial tumor" [J:47225] is_a: MT:0002019 ! tumor incidence [Term] id: MT:0002015 name: epithelioid cysts namespace: Trait.ontology def: "abnormal membranous sacs appearing in an epithelium" [J:51296] is_a: MT:0001191 ! skin condition is_a: MT:0002019 ! tumor incidence [Term] id: MT:0002016 name: ovarian cysts namespace: Trait.ontology def: "cystic ovary; usually refers to a benign growth" [J:35782, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "cystic ovary" EXACT [] synonym: "dermoid cysts" EXACT [] is_a: MT:0001126 ! ovary morphology [Term] id: MT:0002017 name: spontaneous tumor namespace: Trait.ontology def: "higher than normal incidence of tumors with unknown cause" [J:44427] is_a: MT:0002019 ! tumor incidence [Term] id: MT:0002018 name: malignant tumors namespace: Trait.ontology def: "higher than normal incidence of locally invasive, destructive and metastatic tumors " [J:44427, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002019 ! tumor incidence [Term] id: MT:0002019 name: tumor incidence namespace: Trait.ontology def: "deviation from the expected number of abnormal growths of a specific tissue in a specific population" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0002166 ! tumor susceptibility [Term] id: MT:0002021 name: susceptibility to induced tumors namespace: Trait.ontology def: "higher than normal frequency of tumor incidence induced by a carcinogen or mutagen" [J:44427] is_a: MT:0005514 ! susceptibility to tumor development [Term] id: MT:0002022 name: lymphoma namespace: Trait.ontology def: "neoplasm of any lymphoid tissue" [J:18542, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "lymphoid tumor" EXACT [] is_a: MT:0002019 ! tumor incidence [Term] id: MT:0002023 name: B cell derived lymphoma namespace: Trait.ontology def: "heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes" [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "B-cell derived lymphoma" EXACT [] is_a: MT:0002022 ! lymphoma [Term] id: MT:0002024 name: T cell derived lymphoma namespace: Trait.ontology def: "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "T-cell derived lymphoma" EXACT [] is_a: MT:0002022 ! lymphoma [Term] id: MT:0002025 name: B cell/T cell derived lymphoma namespace: Trait.ontology def: "group of heterogeneous lymphoid tumors representing malignant transformations of both B-lymphocytes and T-lymphocytes" [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "B cell/T cell derived lymphoma" EXACT [] synonym: "B-cell/T-cell derived lymphoma" EXACT [] is_a: MT:0002022 ! lymphoma [Term] id: MT:0002026 name: leukemia namespace: Trait.ontology def: "progressive proliferation of abnormal leukocytes in hematopoietic tissues, organs and blood" [J:18542, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002019 ! tumor incidence [Term] id: MT:0002027 name: lung adenocarcinoma namespace: Trait.ontology def: "malignant neoplasm of epithelial cells in the lung" [J:18542, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002038 ! carcinoma [Term] id: MT:0002028 name: hepatoma namespace: Trait.ontology def: "malignant tumor composed of neoplastic liver cells" [J:18542, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "hepatocarcinoma" EXACT [] synonym: "hepatocellular carcinoma" EXACT [] is_a: MT:0002019 ! tumor incidence [Term] id: MT:0002029 name: fibrosarcoma namespace: Trait.ontology def: "malignant neoplasm derived from deep fibrous tissue" [J:18542, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002032 ! sarcoma [Term] id: MT:0002030 name: neurofibrosarcoma namespace: Trait.ontology def: "malignant neoplasm of fibrous tissue of the nervous system" [J:18542, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002032 ! sarcoma [Term] id: MT:0002031 name: adrenal tumor namespace: Trait.ontology def: "tumors of the adrenal gland, including phaeochomocytomas" [J:18542, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002019 ! tumor incidence [Term] id: MT:0002032 name: sarcoma namespace: Trait.ontology def: "connective tissue neoplasm associated with the proliferation of mesodermal cells" [J:58877, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002019 ! tumor incidence [Term] id: MT:0002033 name: malignant triton tumors namespace: Trait.ontology def: " malignant tumor with neurogenic and myogenic differentiation; usually arises in tissues of neural crest origin" [J:58877, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "MTTs" EXACT [] is_a: MT:0002019 ! tumor incidence [Term] id: MT:0002034 name: malignant peripheral nerve sheath tumors namespace: Trait.ontology def: "a highly aggressive tumor arising from the connective tissue surrounding peripheral nerves " [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] synonym: "malignant neurolemmoma" RELATED [] synonym: "MPNSTs" EXACT [] is_a: MT:0002019 ! tumor incidence [Term] id: MT:0002035 name: leiomyosarcoma namespace: Trait.ontology def: "malignant tumor derived from smooth (nonstriated) muscle" [J:58877, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002032 ! sarcoma [Term] id: MT:0002036 name: rhabdomyosarcoma namespace: Trait.ontology def: "malignant tumor derived from skeletal (striated) muscle" [J:58877, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002032 ! sarcoma [Term] id: MT:0002037 name: fibrohistocytoma namespace: Trait.ontology def: "slowly growing skin nodule derived from cellular fibrous tissue; often surrounds capillaries" [J:58877, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "dermatofibroma" EXACT [] is_a: MT:0002019 ! tumor incidence [Term] id: MT:0002038 name: carcinoma namespace: Trait.ontology def: "malignant neoplasm arising from epithelial cells, usually glandular or squamous" [J:58877, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002019 ! tumor incidence [Term] id: MT:0002039 name: neuroblastoma namespace: Trait.ontology def: "malignant neoplasm characterized by immature nerve cells of embryonic type" [J:58877, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002019 ! tumor incidence [Term] id: MT:0002041 name: pituitary adenoma namespace: Trait.ontology def: "appearance of benign neoplasms of the pituitary" [J:33042, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002815 ! adenoma [Term] id: MT:0002043 name: colonic hamartoma namespace: Trait.ontology def: "tumor-like focal abnormalities of the intestines; rarely neoplastic" [J:47050] is_a: MT:0002019 ! tumor incidence [Term] id: MT:0002044 name: colonic adenoma namespace: Trait.ontology def: "benign tumors of the large intestine" [J:38772] synonym: "colonic adenomata" EXACT [] is_a: MT:0002404 ! intestinal adenoma [Term] id: MT:0002045 name: renal cystadenoma namespace: Trait.ontology def: "benign cystic neoplasm of the kidney derived from glandular epithelium origin" [J:57631, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002815 ! adenoma [Term] id: MT:0002046 name: renal carcinoma namespace: Trait.ontology def: "malignant neoplasm of the kidney" [J:57631, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002038 ! carcinoma [Term] id: MT:0002047 name: hepatic hemangioma namespace: Trait.ontology def: "neoplastic- like masses in the liver; often undergoes spontaneous regression" [J:57631, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "liver angioma" EXACT [] is_a: MT:0002947 ! hemangioma [Term] id: MT:0002048 name: lung adenoma namespace: Trait.ontology def: "benign epithelial neoplasm of the lung" [J:57631, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002815 ! adenoma [Term] id: MT:0002049 name: extremity angiosarcoma namespace: Trait.ontology def: "malignant neoplasm of soft tissues; thought to arise from endothelial cells of blood vessels" [J:57631, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0003667 ! hemangiosarcoma [Term] id: MT:0002050 name: pheochromocytoma namespace: Trait.ontology def: "a benign neoplasm derived from adrenal medullary cells; usually associated with hypertension" [J:63229, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002031 ! adrenal tumor [Term] id: MT:0002051 name: skin papilloma namespace: Trait.ontology def: "a circumscribed, benign epithelial tumor projecting from the surrounding surface" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002014 ! papilloma is_a: MT:0005276 ! skin tumor [Term] id: MT:0002059 name: seminal gland morphology namespace: Trait.ontology alt_id: MT:0000656 def: "anomalous structure of one of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal seminal gland" EXACT [] synonym: "abnormal seminal vesicles" EXACT [] is_a: MT:0000653 ! sex gland morphology is_a: MT:0001145 ! male reproductive anatomy [Term] id: MT:0002060 name: skin morphology namespace: Trait.ontology def: "malformation or atypical structure of the membranous protective covering of the body" [J:56777, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] subset: slim_chkn subset: slim_pig synonym: "abnormal cutis" EXACT [] synonym: "abnormal skin anatomy" EXACT [] is_a: MT:0002096 ! skin condition/ morphology [Term] id: MT:0002062 name: conditioning behavior namespace: Trait.ontology xref: MGI:2173567 is_a: MT:0002063 ! learning/memory/conditioning [Term] id: MT:0002063 name: learning/memory/conditioning namespace: Trait.ontology subset: slim_pig xref: MGI:2173568 is_a: MT:0005386 ! behavior/neurological trait [Term] id: MT:0002064 name: seizures namespace: Trait.ontology alt_id: MT:0000946 alt_id: MT:0001493 def: "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] comment: pslim term synonym: "neurological/behavioral: seizures/epilepsy" EXACT [] synonym: "seizures/epilepsy" EXACT [] xref: MGI:2173569 is_a: MT:0003633 ! nervous system physiology [Term] id: MT:0002066 name: motor capabilities/coordination/movement namespace: Trait.ontology subset: slim_pig xref: MGI:2173571 is_a: MT:0005386 ! behavior/neurological trait [Term] id: MT:0002067 name: sensory capabilities/reflexes/nociception namespace: Trait.ontology is_a: MT:0005386 ! behavior/neurological trait [Term] id: MT:0002068 name: parental behavior namespace: Trait.ontology def: "altered behavior of animals towards offspring" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] comment: pslim term synonym: "neurological/behavioral: parental behavior anomalies" EXACT [] xref: MGI:2173573 is_a: MT:0002557 ! social/conspecific interaction [Term] id: MT:0002069 name: eating/drinking behavior namespace: Trait.ontology comment: pslim term subset: slim_cattle subset: slim_chkn subset: slim_pig xref: MGI:2173574 is_a: MT:0005386 ! behavior/neurological trait [Term] id: MT:0002070 name: sleep pattern/circadian rhythm namespace: Trait.ontology comment: pslim term is_a: MT:0005386 ! behavior/neurological trait [Term] id: MT:0002071 name: other behavior namespace: Trait.ontology synonym: "neurological/behavioral: other anomalies" EXACT [] is_a: MT:0005386 ! behavior/neurological trait [Term] id: MT:0002073 name: hair growth namespace: Trait.ontology alt_id: MT:0000409 def: "absence or reduced amount of hair or abnormal onset of hair growth cycle or development" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] comment: pslim term subset: slim_pig synonym: "coat: hair growth defects" EXACT [] synonym: "hair growth abnormalities" EXACT [] xref: MGI:2173539 is_a: MT:0000367 ! coat/ hair morphology [Term] id: MT:0002074 name: hair texture namespace: Trait.ontology alt_id: MT:0002077 def: "irregular or unusual appearance of the structure of the hair" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] comment: pslim term synonym: "coat: hair texture defects" EXACT [] synonym: "hair texture abnormalities" EXACT [] xref: MGI:2173540 is_a: MT:0000367 ! coat/ hair morphology [Term] id: MT:0002075 name: coat color namespace: Trait.ontology alt_id: MT:0000368 def: "irregular or unusual pigmentation of the hair in relation to control animals" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] comment: pslim term subset: slim_cattle subset: slim_pig synonym: "coat: color anomalies" EXACT [] xref: MGI:2173541 is_a: MT:0000367 ! coat/ hair morphology is_a: MT:0001186 ! pigmentation trait [Term] id: MT:0002076 name: hair follicle structure/orientation namespace: Trait.ontology def: "malformation or misalignment of the epidermis from which the hair shaft develops" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] comment: pslim term synonym: "coat: hair follicle structure/orientation anomalies" EXACT [] xref: MGI:2173542 is_a: MT:0000367 ! coat/ hair morphology [Term] id: MT:0002078 name: glucose homeostasis namespace: Trait.ontology def: "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] subset: slim_chkn subset: slim_pig synonym: "abnormal glucose metabolism" EXACT [] synonym: "metabolism: abnormal glucose homeostasis" EXACT [] xref: MGI:2173579 is_a: MT:0001764 ! homeostasis [Term] id: MT:0002084 name: developmental patterning namespace: Trait.ontology alt_id: MT:0001702 def: "abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] comment: phenoslim term synonym: "embryogenesis: developmental patterning abnormalities" EXACT [] xref: MGI:2173529 is_a: MT:0001672 ! embryogenesis/ development [Term] id: MT:0002085 name: embryonic tissue morphology namespace: Trait.ontology alt_id: MT:0001673 def: "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] comment: phenoslim term synonym: "abnormal embryogenesis" EXACT [] synonym: "embryogenesis: embryonic tissue dysmorphology" EXACT [] xref: MGI:2173530 is_a: MT:0001672 ! embryogenesis/ development [Term] id: MT:0002086 name: extraembryonic tissue morphology namespace: Trait.ontology alt_id: MT:0001708 alt_id: MT:0001709 def: "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, J:40594, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] comment: Phenoslim term synonym: "abnormal extraembryonic tissues" EXACT [] synonym: "embryogenesis: extraembryonic tissue dysmorphology" EXACT [] xref: MGI:2173531 is_a: MT:0001672 ! embryogenesis/ development [Term] id: MT:0002088 name: embryonic growth/weight/body size namespace: Trait.ontology def: "limited or accelerated growth or development apparent during the embryonic period (sensu Mus: up to E14, or the completion of organogenesis)" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] comment: Phenoslim term synonym: "growth/weight/body size abnormality: embryonic" EXACT [] xref: MGI:2173533 is_a: MT:0004196 ! prenatal growth/weight/body size [Term] id: MT:0002089 name: postnatal growth/weight/body size namespace: Trait.ontology alt_id: MT:0001252 def: "increased or decreased average body size, weight or growth characteristic abnormalities manifesting after birth" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] comment: phenoslim term subset: slim_cattle subset: slim_chkn subset: slim_pig synonym: "abnormal trunk/ body shape" EXACT [] synonym: "growth/weight/body size abnormality: postnatal" EXACT [] synonym: "trunk/ body shape abnormalities" EXACT [] xref: GO:0040007 xref: GO:0040014 xref: MGI:2173534 is_a: MT:0005378 ! growth/size trait [Term] id: MT:0002090 name: vision namespace: Trait.ontology alt_id: MT:0001991 alt_id: MT:0002000 def: "inability or decreased ability to see" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] comment: phenoslim term synonym: "abnormal visual ability" EXACT [] synonym: "eye: visual defects" EXACT [] synonym: "visual defects" EXACT [] xref: MGI:2173535 is_a: MT:0005253 ! eye physiology [Term] id: MT:0002092 name: eye morphology namespace: Trait.ontology alt_id: MT:0001285 alt_id: MT:0001294 alt_id: MT:0001295 def: "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] comment: phenoslim term synonym: "abnormal eyes" EXACT [] synonym: "eye abnormalities" EXACT [] synonym: "eye malformation" EXACT [] synonym: "eye tissue abnormalities" EXACT [] synonym: "eye: dysmorphology" EXACT [] synonym: "visual system abnormalities" EXACT [] synonym: "visual system defects" EXACT [] xref: GO:0001654 xref: MGI:2173536 is_a: MT:0005391 ! vision/eye trait [Term] id: MT:0002093 name: cornea/lens morphology namespace: Trait.ontology def: "any dysmorphology or complete or partial opacity of the lens or cornea" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] comment: phenoslim term synonym: "eye: corneal/lens defect" EXACT [] xref: MGI:2173537 is_a: MT:0005193 ! anterior eye segment morphology [Term] id: MT:0002095 name: skin pigmentation namespace: Trait.ontology alt_id: MT:0001187 def: "variation of skin color or complexion" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] comment: pslim term synonym: "skin: pigmentation anomalies" EXACT [] xref: MGI:2173544 is_a: MT:0001186 ! pigmentation trait is_a: MT:0002096 ! skin condition/ morphology [Term] id: MT:0002096 name: skin condition/ morphology namespace: Trait.ontology alt_id: MT:0001185 def: "malformed or atypical condition of the skin" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] comment: pslim term subset: slim_chkn subset: slim_pig synonym: "abnormal skin" EXACT [] synonym: "skin abnormalities" EXACT [] synonym: "skin: texture/condition anomalies" EXACT [] xref: MGI:2173545 is_a: MT:0005393 ! skin/coat/nails/feathers trait [Term] id: MT:0002098 name: vibrissae morphology namespace: Trait.ontology alt_id: MT:0001271 def: "irregular or unusual structure, appearance, or alignment of the vibrissae" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] comment: pslim term synonym: "abnormal vibrissae" EXACT [] synonym: "abnormal whiskers" EXACT [] synonym: "vibrissae abnormalities" EXACT [] synonym: "vibrissae defects" EXACT [] synonym: "vibrissae: dysmorphology" EXACT [] xref: MGI:2173547 is_a: MT:0005392 ! touch/vibrissae trait [Term] id: MT:0002100 name: tooth morphology namespace: Trait.ontology alt_id: MT:0000115 alt_id: MT:0000123 def: "atypical size, shape or hard tissue structure of the teeth " [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] comment: pslim term synonym: "abnormal teeth" EXACT [] synonym: "abnormal tooth" EXACT [] synonym: "Abnormal Tooth Structure" EXACT [] synonym: "teeth abnormalities" EXACT [] synonym: "teeth: tooth dysmorphology" EXACT [] xref: MGI:2173553 is_a: MT:0002116 ! craniofacial bone morphology [Term] id: MT:0002102 name: ear morphology namespace: Trait.ontology alt_id: MT:0000014 alt_id: MT:0000016 def: "form, structure or development of any of the parts of the ear or vestibular system" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] comment: pslim term synonym: "auditory/ vestibular system abnormalities" EXACT [] synonym: "auditory/ vestibular system morphology" EXACT [] synonym: "ear development/ ear formation" EXACT [] synonym: "ears: dysmorphology" EXACT [] xref: GO:0042471 xref: MGI:2173556 is_a: MT:0005377 ! hearing/vestibular/ear trait [Term] id: MT:0002104 name: hearing physiology namespace: Trait.ontology def: "processes involved in the perception of sound" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] comment: pslim term synonym: "auditory perception" EXACT [] synonym: "auditory physiology" RELATED [] xref: GO:0007605 xref: MGI:2173555 is_a: MT:0003878 ! ear physiology [Term] id: MT:0002106 name: muscle physiology namespace: Trait.ontology alt_id: MT:0002105 def: "anomalous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] comment: former pslim term subset: slim_chkn subset: slim_pig synonym: "muscle physiology abnormalities" EXACT [] synonym: "musculature: physiological defects" EXACT [] xref: MGI:2173559 is_a: MT:0005369 ! muscle trait [Term] id: MT:0002108 name: muscle morphology namespace: Trait.ontology alt_id: MT:0000728 alt_id: MT:0000758 def: "abnormal development of muscle tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] comment: pslim term subset: slim_cattle subset: slim_chkn subset: slim_pig synonym: "abnormal muscle" EXACT [] synonym: "abnormal musculature" EXACT [] synonym: "muscle abnormalities" EXACT [] synonym: "musculature abnormalities" EXACT [] synonym: "musculature: muscle dysmorphology" EXACT [] xref: MGI:2173558 is_a: MT:0005369 ! muscle trait [Term] id: MT:0002109 name: limb morphology namespace: Trait.ontology alt_id: MT:0000546 def: "form, structure, or number of limbs" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] comment: pslim term subset: slim_cattle subset: slim_chkn subset: slim_pig synonym: "abnormal limb" EXACT [] synonym: "extremities: limb dysmorphology" EXACT [] synonym: "limb abnormalities" EXACT [] xref: MGI:2173549 is_a: MT:0000545 ! limbs/digits/tail morphology [Term] id: MT:0002110 name: digit morphology namespace: Trait.ontology alt_id: MT:0000560 def: "abnormal development of the digits resulting in structural abnormality" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] comment: pslim term synonym: "abnormal digit" EXACT [] synonym: "digit abnormalities" EXACT [] synonym: "extremities: digit dysmorphology" EXACT [] xref: MGI:2173550 is_a: MT:0004271 ! paw/hand/foot/hoof morphology [Term] id: MT:0002111 name: tail morphology namespace: Trait.ontology alt_id: MT:0000584 alt_id: MT:0005173 def: "abnormal development of the tail resulting in structural abnormality" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] comment: pslim term synonym: "abnormal tail" EXACT [] synonym: "abnormal tail structure" EXACT [] synonym: "extremities: tail dysmorphology" EXACT [] synonym: "tail abnormalities" EXACT [] synonym: "tail structure abnormalities" EXACT [] xref: MGI:2173551 is_a: MT:0000545 ! limbs/digits/tail morphology [Term] id: MT:0002113 name: skeleton development namespace: Trait.ontology alt_id: MT:0000056 alt_id: MT:0001534 alt_id: MT:0001537 def: "anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] comment: pslim term synonym: "abnormal bone development" EXACT [] synonym: "abnormal bone formation/ structure" EXACT [] synonym: "abnormal skeletogenesis" EXACT [] synonym: "skeletal: osteogenesis/developmental anomalies" EXACT [] xref: MGI:2173561 is_a: MT:0005508 ! skeleton morphology [Term] id: MT:0002114 name: axial skeleton morphology namespace: Trait.ontology def: "abnormal development of vertebral, spinal or sternal bones resulting in morphological abnormality" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] comment: pslim term subset: slim_cattle subset: slim_pig synonym: "skeletal: axial defects" EXACT [] xref: MGI:2173562 is_a: MT:0005508 ! skeleton morphology [Term] id: MT:0002115 name: skeleton extremities morphology namespace: Trait.ontology def: "abnormal development of limb, foot or tail bones resulting in morphological abnormality" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] comment: pslim term subset: slim_chkn subset: slim_pig synonym: "skeletal: extremities defects" EXACT [] xref: MGI:2173563 is_a: MT:0000545 ! limbs/digits/tail morphology is_a: MT:0005508 ! skeleton morphology [Term] id: MT:0002116 name: craniofacial bone morphology namespace: Trait.ontology alt_id: MT:0000072 def: "abnormal development of cranial or facial bones resulting in morphological abnormality" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] comment: pslim term synonym: "cranial/facial bone defect" EXACT [] synonym: "craniofacial bone defects" EXACT [] synonym: "skeletal: craniofacial defects" EXACT [] xref: MGI:2173564 is_a: MT:0000428 ! craniofacial morphology is_a: MT:0005508 ! skeleton morphology [Term] id: MT:0002118 name: lipid homeostasis namespace: Trait.ontology def: "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] subset: slim_cattle subset: slim_chkn subset: slim_pig synonym: "metabolism: abnormal lipid homeostasis" EXACT [] xref: MGI:2173578 is_a: MT:0001764 ! homeostasis [Term] id: MT:0002121 name: metabolism namespace: Trait.ontology alt_id: MT:0002120 def: "altered chemical and physical processes of the body or of a tissue, not due to lipid or glucose chemistry" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] subset: slim_chkn subset: slim_pig synonym: "metabolism: other metabolic defect" EXACT [] synonym: "metabolism: other metabolic defect measured by clinical chemistry" EXACT [] xref: MGI:2173580 xref: MGI:2173581 is_a: MT:0005376 ! homeostasis/metabolism trait [Term] id: MT:0002123 name: hematopoiesis namespace: Trait.ontology alt_id: MT:0000236 alt_id: MT:0000241 alt_id: MT:0001600 alt_id: MT:0001604 alt_id: MT:0001605 alt_id: MT:0002402 def: "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] comment: pslim term subset: slim_cattle subset: slim_chkn subset: slim_pig synonym: "abnormal blood development" EXACT [] synonym: "abnormal definitive hematopoiesis" EXACT [] synonym: "abnormal hematogenesis" EXACT [] synonym: "abnormal hematosis" EXACT [] synonym: "abnormal hemogenesis" EXACT [] synonym: "abnormal hemopoiesis" EXACT [] synonym: "abnormal sanguification" EXACT [] synonym: "blood development abnormalities" EXACT [] synonym: "deregulated hematopoiesis" EXACT [] synonym: "hematology: hematopoietic anomalies" EXACT [] synonym: "hematopoiesis abnormalities" EXACT [] synonym: "myeloid stem cell abnormalities" EXACT [] xref: MGI:2173583 is_a: MT:0002429 ! blood cell morphology/development [Term] id: MT:0002124 name: red blood cell namespace: Trait.ontology def: "anomaly in the structure or maintenance of erythrocytes or oxygen-transporting material in the blood" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] comment: pslim term subset: slim_cattle subset: slim_chkn synonym: "abnormal erythrocyte" EXACT [] synonym: "hematology: abnormal red blood cell count/anemia" EXACT [] xref: MGI:2173584 is_a: MT:0000245 ! erythropoiesis [Term] id: MT:0002127 name: cardiovascular system morphology namespace: Trait.ontology alt_id: MT:0000177 def: "any measurable or observable characteristic related to the shape, structure, color or pattern of the heart or vasculature" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] subset: slim_chkn subset: slim_pig relationship: part_of MT:0005385 ! cardiovascular system trait [Term] id: MT:0002128 name: blood circulation namespace: Trait.ontology alt_id: MT:0000308 alt_id: MT:0001632 def: "any measurable characteristic of the flow of blood within the body" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator", RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] comment: pslim term xref: MGI:2173588 is_a: MT:0001544 ! cardiovascular system physiology [Term] id: MT:0002132 name: respiratory system morphology namespace: Trait.ontology alt_id: MT:0001174 def: "anomalous structure of pulmonary tissues" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] comment: pslim term subset: slim_cattle subset: slim_chkn subset: slim_pig synonym: "respiratory system abnormalities" EXACT [] synonym: "respiratory system: dysmorphology" EXACT [] xref: MGI:2173592 is_a: MT:0005388 ! respiratory system trait [Term] id: MT:0002133 name: respiratory system physiology namespace: Trait.ontology def: "anomalous function of the pulmonary system; inability or reduced ability to intake and exchange oxygen and carbon dioxide with the environment" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] comment: pslim term subset: slim_pig synonym: "abnormal respiratory function" EXACT [] synonym: "respiratory system dysfunction" EXACT [] synonym: "respiratory system physiology abnormalities" EXACT [] synonym: "respiratory system: respiratory distress/failure/functional anomalies" EXACT [] xref: MGI:2173593 is_a: MT:0005388 ! respiratory system trait [Term] id: MT:0002135 name: kidney morphology namespace: Trait.ontology alt_id: MT:0000518 def: "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] comment: pslim term synonym: "abnormal kidney" EXACT [] synonym: "abnormal renal morphology" EXACT [] synonym: "kidney abnormalities" EXACT [] synonym: "kidney/renal system: dysmorphology" EXACT [] xref: MGI:2173595 is_a: MT:0000516 ! urinary system morphology [Term] id: MT:0002136 name: kidney physiology namespace: Trait.ontology def: "altered ability or inability to excrete urine, not due to anatomical defect" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] comment: pslim term synonym: "abnormal kidney function" EXACT [] synonym: "kidney/renal system: functional anomalies" EXACT [] xref: MGI:2173596 is_a: MT:0005502 ! urinary system physiology [Term] id: MT:0002138 name: liver/biliary system morphology namespace: Trait.ontology alt_id: MT:0002172 def: "structural abnormality or aberrant development of any of the tissues of the liver or biliary system" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] comment: pslim term subset: slim_chkn subset: slim_pig synonym: "hepatic system abnormalities" EXACT [] synonym: "hepatic system defects" EXACT [] synonym: "liver/hepatic system: dysmorphology" EXACT [] xref: MGI:2173598 is_a: MT:0005370 ! liver/biliary system trait [Term] id: MT:0002139 name: liver/biliary system physiology namespace: Trait.ontology alt_id: MT:0002173 def: "altered function of the liver not due to anatomical defect" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] comment: pslim term synonym: "abnormal hepatic system physiology" EXACT [] synonym: "hepatic system physiology abnormalities" EXACT [] synonym: "liver/hepatic system: functional anomalies" EXACT [] xref: MGI:2173599 is_a: MT:0005370 ! liver/biliary system trait [Term] id: MT:0002144 name: B lymphocyte development namespace: Trait.ontology alt_id: MT:0001801 alt_id: MT:0001803 alt_id: MT:0002438 def: "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] comment: pslim term synonym: "abnormal B cell development" EXACT [] synonym: "abnormal B cell maturation" EXACT [] synonym: "abnormal B cell morphology/development" EXACT [] synonym: "abnormal B lymphocyte maturation" EXACT [] synonym: "abnormal B-cell development" EXACT [] synonym: "abnormal B-cell maturation" EXACT [] synonym: "abnormal lymphoid development/ B lymphocyte defects" EXACT [] synonym: "B cell abnormalities" EXACT [] synonym: "B lymphocyte abnormalities" EXACT [] synonym: "B-cell abnormalities" EXACT [] synonym: "immune system: lymphoid development/ B lymphocyte defects" EXACT [] xref: MGI:2173604 is_a: MT:0002401 ! lymphopoiesis is_a: MT:0002619 ! lymphocyte morphology/development [Term] id: MT:0002145 name: T lymphocyte development namespace: Trait.ontology alt_id: MT:0001821 alt_id: MT:0001822 alt_id: MT:0002431 alt_id: MT:0002489 def: "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] comment: pslim term synonym: "abnormal lymphoid development/ T lymphocyte defects" EXACT [] synonym: "abnormal T cell development" EXACT [] synonym: "abnormal T cell maturation" EXACT [] synonym: "abnormal T cell morphology/development" EXACT [] synonym: "abnormal T-cell development" EXACT [] synonym: "abnormal T-cell maturation" EXACT [] synonym: "abnormal thymocyte development" EXACT [] synonym: "immune system: lymphoid development/ T lymphocyte defects" EXACT [] synonym: "T lymphocyte abnormalities" EXACT [] synonym: "T-cell abnormalities" EXACT [] xref: MGI:2173605 is_a: MT:0002401 ! lymphopoiesis is_a: MT:0002619 ! lymphocyte morphology/development [Term] id: MT:0002148 name: immune system: hypersensitivity namespace: Trait.ontology def: "immune response that results in tissue injury" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] comment: pslim term synonym: "immunologically mediated tissue injury" EXACT [] xref: MGI:2173608 is_a: MT:0001790 ! immune system physiology [Term] id: MT:0002151 name: neural tube morphology/development namespace: Trait.ontology alt_id: MT:0000922 def: "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] comment: pslim term synonym: "abnormal neural tube" EXACT [] synonym: "abnormal neural tube morphology" EXACT [] synonym: "central nervous system: neural tube defects" EXACT [] synonym: "neural tube defects" EXACT [] xref: GO:0007420 xref: MGI:2173611 is_a: MT:0003861 ! nervous system development [Term] id: MT:0002152 name: brain morphology namespace: Trait.ontology alt_id: MT:0000770 alt_id: MT:0000775 def: "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk] comment: pslim term synonym: "abnormal brain" EXACT [] synonym: "abnormal brain structure" EXACT [] synonym: "brain abnormalities" EXACT [] synonym: "brain structure abnormalities" EXACT [] synonym: "central nervous system: brain dysmorphology" EXACT [] xref: MGI:2173612 is_a: MT:0003632 ! nervous system morphology [Term] id: MT:0002160 name: reproductive system morphology namespace: Trait.ontology alt_id: MT:0001114 alt_id: MT:0001115 def: "structural or developmental anomaly of any of the tissues involved in the reproductive system" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] comment: pslim term subset: slim_cattle subset: slim_chkn subset: slim_pig synonym: "abnormal reproductive anatomy" EXACT [] synonym: "abnormal reproductive system" EXACT [] synonym: "reproductive system abnormalities" EXACT [] synonym: "reproductive system defects" EXACT [] synonym: "reproductive system: dysmorphology" EXACT [] xref: MGI:2173620 is_a: MT:0005389 ! reproductive system trait [Term] id: MT:0002161 name: fertility/fecundity namespace: Trait.ontology alt_id: MT:0001920 def: "reduced ability or inability to produce live offspring" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] comment: pslim term subset: slim_cattle subset: slim_chkn subset: slim_pig synonym: "abnormal fecundity" EXACT [] synonym: "reproductive system: fertility/fecundity anomalies" EXACT [] xref: MGI:2173621 is_a: MT:0001919 ! reproductive system physiology [Term] id: MT:0002163 name: gland morphology namespace: Trait.ontology alt_id: MT:0000594 def: "abnormal development of any glandular tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] comment: pslim term subset: slim_cattle subset: slim_pig synonym: "abnormal glands" EXACT [] synonym: "gland abnormalities" EXACT [] synonym: "glands: dysmorphology" EXACT [] xref: MGI:2173623 is_a: MT:0005379 ! endocrine/exocrine gland trait [Term] id: MT:0002164 name: gland physiology namespace: Trait.ontology alt_id: MT:0001733 alt_id: MT:0001738 alt_id: MT:0002692 def: "altered glandular secretion not due to anatomical defect" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] comment: pslim term subset: slim_cattle subset: slim_pig synonym: "abnormal endocrine gland function" EXACT [] synonym: "abnormal endocrine system physiology" EXACT [] synonym: "abnormal gland function" EXACT [] synonym: "endocrine system physiology abnormalities" EXACT [] synonym: "gland function abnormalities" EXACT [] synonym: "glands: functional anomalies" EXACT [] xref: MGI:2173624 is_a: MT:0005379 ! endocrine/exocrine gland trait [Term] id: MT:0002166 name: tumor susceptibility namespace: Trait.ontology def: "greater than or less than the average number of tumors, usually a specific type, arising in a given strain when compared to controls" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] comment: pslim term synonym: "tumorigenesis: altered tumor susceptibility/resistance" EXACT [] xref: MGI:2173626 is_a: MT:0002006 ! tumorigenesis [Term] id: MT:0002174 name: gastrulation movements namespace: Trait.ontology def: "failure of embryonic cells to migrate, or migrate to the appropriate target during the development and invagination of the primary germ layers" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, J:52418] xref: GO:0007669 is_a: MT:0001695 ! gastrulation [Term] id: MT:0002176 name: brain weight namespace: Trait.ontology def: "greater than average weight of the brain" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0000771 ! brain size [Term] id: MT:0002177 name: outer ear morphology namespace: Trait.ontology def: "malformation or malfunction of any components of the auricles or external acoustic meatus" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal pinna morphology" EXACT [] is_a: MT:0002102 ! ear morphology [Term] id: MT:0002181 name: brain cell morphology namespace: Trait.ontology def: "any malformation or malfunction of any or all brain cell types" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] synonym: "abnormal brain cells" EXACT [] synonym: "brain cell abnormalities" EXACT [] is_a: MT:0002152 ! brain morphology [Term] id: MT:0002182 name: astrocyte morphology namespace: Trait.ontology def: "anomalous structure, number or composition of one of the large neuroglia cells of nervous tissue" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal astrocytes" EXACT [] synonym: "abnormal astroglia" EXACT [] is_a: MT:0000952 ! CNS glia morphology [Term] id: MT:0002183 name: gliosis namespace: Trait.ontology def: "increased growth pattern of neuroglia in a damaged area of the brain or spinal cord" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002182 ! astrocyte morphology [Term] id: MT:0002184 name: innervation namespace: Trait.ontology def: "the malformation, misprojection or malfunction of the connection of nerve fibers with a target" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] synonym: "abnormal axonal projection" EXACT [] synonym: "abnormal neuronal projection" EXACT [] synonym: "innervation abnormalities" EXACT [] is_a: MT:0003632 ! nervous system morphology [Term] id: MT:0002185 name: ectopia namespace: Trait.ontology alt_id: MT:0002186 def: "congenital positional anomaly or displacement of any part of the body or organ" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "heterotopia" EXACT [] is_a: MT:0005395 ! other trait [Term] id: MT:0002187 name: fibula morphology namespace: Trait.ontology def: "malformation of the lateral and smaller bone of the lower limb" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal fibula" EXACT [] is_a: MT:0003723 ! long bone morphology [Term] id: MT:0002189 name: heart muscle trabeculae integrity namespace: Trait.ontology def: "any measurable characteristic pertaining to the the structural completeness or structural soundness of the supporting bundles of muscular fibers lining the walls of the heart" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] synonym: "cardiac muscle trabeculae integrity" RELATED [] synonym: "myocardial trabeculae integrity" RELATED [] relationship: part_of MT:0000062 ! heart muscle trabeculae morphology relationship: part_of MT:0000073 ! heart muscle integrity [Term] id: MT:0002191 name: artery morphology namespace: Trait.ontology def: "any measurable or observable characteristic related to the shape, structure, color or pattern of the blood vessels that carry blood away from the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] xref: MP:0002191 is_a: MT:0001614 ! blood vessel morphology [Term] id: MT:0002192 name: hydrops fetalis namespace: Trait.ontology def: "an abnormal accumulation of serous fluid in fetal tissues" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] subset: slim_cattle synonym: "fetal edema" EXACT [] is_a: MT:0001785 ! edema [Term] id: MT:0002198 name: skin pigmentation pattern namespace: Trait.ontology def: "arrangement of pigmented and/or unpigmented patches of skin" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0002095 ! skin pigmentation [Term] id: MT:0002199 name: brain commissure morphology namespace: Trait.ontology def: "absent or defective structure in a bundle of nerve fibers connecting the two brain hemispheres" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal brain commissure" EXACT [] synonym: "abnormal commissure" EXACT [] is_a: MT:0002152 ! brain morphology [Term] id: MT:0002200 name: brain ventricle/choroid plexus morphology namespace: Trait.ontology def: "malformation or absence of the brain ventricles or their associated choroid plexuses" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] comment: suggested from TGMC synonym: "abnormal brain ventricle/choroid plexus" EXACT [] synonym: "abnormal choroid/ventricle" EXACT [] is_a: MT:0002152 ! brain morphology [Term] id: MT:0002204 name: neurotransmitter level namespace: Trait.ontology def: "aberrant concentration of endogenous signaling molecules secreted by neurons that alter the behavior of neurons or effector cells" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] synonym: "neurotransmitter abnormalities" EXACT [] is_a: MT:0003635 ! synaptic transmission [Term] id: MT:0002206 name: CNS synaptic transmission namespace: Trait.ontology def: "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal CNS neurotransmission" EXACT [] synonym: "abnormal synaptic transmission" EXACT [] is_a: MT:0003635 ! synaptic transmission [Term] id: MT:0002207 name: long term potentiation namespace: Trait.ontology alt_id: MT:0001472 alt_id: MT:0001896 alt_id: MT:0001897 alt_id: MT:0002154 def: "alterations in a persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, Principles of Neural Science_3rd edition:ISBN 0-8385-8034-3] synonym: "abnormal LTP" EXACT [] synonym: "abnormal LTP: CA1 region" EXACT [] synonym: "abnormal LTP: CA3 region" EXACT [] synonym: "central nervous system: LTP anomalies" EXACT [] synonym: "long term potentiation abnormalities" EXACT [] xref: MGI:2173614 is_a: MT:0002206 ! CNS synaptic transmission [Term] id: MT:0002208 name: germ cell morphology namespace: Trait.ontology def: "anomalous structure of the germ cell, that is, any of the reproductive (generative) cells of a multicellular organism, whether they are undifferentiated or fully differentiated" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal gamete morphology" EXACT [] is_a: MT:0001929 ! gametogenesis [Term] id: MT:0002209 name: germ cell number namespace: Trait.ontology def: "reduced numbers of any of the reproductive (generative) cells of a multicellular organism, whether they are undifferentiated or fully differentiated" [pvb:Pierre Vanden Borre_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001929 ! gametogenesis [Term] id: MT:0002210 name: sex determination namespace: Trait.ontology alt_id: MT:0001936 def: "anomaly of primary or secondary sexual development or characteristics" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] subset: slim_cattle subset: slim_chkn subset: slim_pig synonym: "abnormal reproductive system development" EXACT [] synonym: "abnormal sexual differentiation" EXACT [] is_a: MT:0002160 ! reproductive system morphology [Term] id: MT:0002211 name: primary sex determination namespace: Trait.ontology def: "aberrant gonadal development resulting in either abnormal or absent gonads or the development of gonads inconsistent with the chromosomal sex" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, llw2:Linda Washburn_Mouse Genome Informatics Curator] subset: slim_pig synonym: "abnormal gonad development" EXACT [] is_a: MT:0002210 ! sex determination [Term] id: MT:0002212 name: secondary sex determination namespace: Trait.ontology def: "gonadal development may or may not be normal, and the phenotype of the animal outside the gonad does not match chromosomal sex or is ambiguous" [llw2:Linda Washburn_Mouse Genome Informatics Curator] subset: slim_cattle subset: slim_chkn subset: slim_pig is_a: MT:0002210 ! sex determination [Term] id: MT:0002213 name: true hermaphroditism namespace: Trait.ontology def: "having both ovarian and testicular tissue present" [llw2:Linda Washburn_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002211 ! primary sex determination [Term] id: MT:0002214 name: streak gonad namespace: Trait.ontology def: "impairment of genital ridge development; aplasia of gonadal tissue which is sometimes replaced with functionless tissue" [llw2:Linda Washburn_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "gonadal streak" EXACT [] is_a: MT:0002211 ! primary sex determination is_a: MT:0003936 ! reproductive system development [Term] id: MT:0002216 name: seminiferous tubule morphology namespace: Trait.ontology def: "malformation of the tubules in the testes where spermatogenesis occurs" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal seminiferous tubules" EXACT [] is_a: MT:0001146 ! testis morphology [Term] id: MT:0002221 name: lymph organ size namespace: Trait.ontology def: "change in the normal size of lymphatic tissues" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] subset: slim_chkn is_a: MT:0002722 ! immune system organ morphology [Term] id: MT:0002222 name: lymph organ cellularity namespace: Trait.ontology def: "change in the normal number of cells within a lymph organ" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] is_a: MT:0002722 ! immune system organ morphology [Term] id: MT:0002224 name: spleen size namespace: Trait.ontology def: "deviation from the normal spleen size" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] subset: slim_chkn is_a: MT:0000689 ! spleen morphology is_a: MT:0002221 ! lymph organ size [Term] id: MT:0002225 name: spleen cellularity namespace: Trait.ontology def: "anomaly in the cellular makeup of the spleen" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "spleen cellularity abnormalities" EXACT [] is_a: MT:0000689 ! spleen morphology is_a: MT:0002222 ! lymph organ cellularity [Term] id: MT:0002227 name: spleen capsule morphology namespace: Trait.ontology def: "anomalous structure of the connective tissue that surrounds the spleen" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] is_a: MT:0000689 ! spleen morphology [Term] id: MT:0002228 name: spleen trabecular vein morphology namespace: Trait.ontology def: "anomalous structure of one of the veins that feed the splenic vein" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Pathology:ISBN 0-397-51047-0] is_a: MT:0000689 ! spleen morphology [Term] id: MT:0002229 name: neural integrity namespace: Trait.ontology def: "a retrogressive impairment of function or destruction of neural tissue" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "neuronal degeneration" EXACT [] is_a: MT:0003633 ! nervous system physiology [Term] id: MT:0002230 name: primitive streak formation namespace: Trait.ontology def: "anomaly in the establishment of the midline ridge of embryonic epiblast that later develops into mesoderm and endoderm" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, The Atlas of Mouse Development:ISBN 0-12-402035-6] is_a: MT:0002231 ! primitive streak morphology [Term] id: MT:0002231 name: primitive streak morphology namespace: Trait.ontology def: "anomaly in the midline ridge of the embryonic epiblast that later develops into mesoderm and endoderm" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, The Atlas of Mouse Development:ISBN 0-12-402035-6] synonym: "defective primitive streak" EXACT [] is_a: MT:0002084 ! developmental patterning [Term] id: MT:0002233 name: nose morphology namespace: Trait.ontology def: "any structural anomaly of the organ that is specialized for smell and is part of the respiratory system" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] subset: slim_pig synonym: "abnormal nose" EXACT [] is_a: MT:0002132 ! respiratory system morphology [Term] id: MT:0002234 name: pharynx morphology namespace: Trait.ontology def: "structural anomaly in the passage between the mouth and the posterior nares and the larynx and esophagus" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "abnormal pharynx" EXACT [] is_a: MT:0002132 ! respiratory system morphology [Term] id: MT:0002235 name: external nares morphology namespace: Trait.ontology def: "any structural anomaly of the anterior opening to the nasal cavity" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "abnormal anterior nares" EXACT [] synonym: "abnormal external nares" EXACT [] synonym: "abnormal nostril" EXACT [] is_a: MT:0002233 ! nose morphology [Term] id: MT:0002236 name: internal nares morphology namespace: Trait.ontology def: "any structural anomaly of the portion of the opening of the nasal cavity into the nasal pharynx " [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "abnormal choanae" EXACT [] synonym: "abnormal internal nares" EXACT [] synonym: "abnormal posterior nares" EXACT [] is_a: MT:0002233 ! nose morphology [Term] id: MT:0002237 name: nasal cavity morphology namespace: Trait.ontology def: "any structural anomaly of the portion of the respiratory tract that extends from the nares to the pharynx; the nasal cavity is lined with ciliated mucosa" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal nasal cavity" EXACT [] is_a: MT:0002233 ! nose morphology [Term] id: MT:0002238 name: nasal mucosa morphology namespace: Trait.ontology alt_id: MT:0001112 def: "any structural anomaly of the mucous membrane that lines the nasal cavity" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] subset: slim_pig synonym: "abnormal nasal epithelium" EXACT [] synonym: "abnormal nasal mucosa" EXACT [] synonym: "abnormal nasal mucous membrane" EXACT [] is_a: MT:0002233 ! nose morphology is_a: MT:0002277 ! respiratory mucosa morphology [Term] id: MT:0002239 name: nasal septum morphology namespace: Trait.ontology def: "any structural anomaly of the structure that separates the two nasal cavities" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal nasal septum" EXACT [] is_a: MT:0002233 ! nose morphology [Term] id: MT:0002240 name: paranasal sinus morphology namespace: Trait.ontology def: "any structural anomaly of these extensions of the nasal cavity" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal paranasal sinuses" EXACT [] is_a: MT:0002233 ! nose morphology [Term] id: MT:0002241 name: laryngeal mucosa goblet cell morphology namespace: Trait.ontology def: "any structural anomaly of the epithelial cells lining the larynx, which produce mucins" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings, Pathology_2nd edition:ISBN 0-397-51047-0] synonym: "abnormal goblet cells of the laryngeal mucosa" EXACT [] is_a: MT:0002261 ! laryngeal mucosa morphology [Term] id: MT:0002242 name: olfactory mucosa morphology namespace: Trait.ontology def: "any structural anomaly of the portion of the nasal mucosa that contains the olfactory sensory endings" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal olfactory epithelium" EXACT [] synonym: "abnormal olfactory mucosa" EXACT [] is_a: MT:0002238 ! nasal mucosa morphology [Term] id: MT:0002243 name: vomeronasal organ morphology namespace: Trait.ontology def: "any structural anomaly of the specialized portion of the nasal septum that is composed of chemosensitive cells and lies anteriorly in the nasal cavity" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] comment: this organ is believed to function in sensing pheromones synonym: "abnormal vomeronasal organ" EXACT [] is_a: MT:0002239 ! nasal septum morphology is_a: MT:0005499 ! olfactory system morphology [Term] id: MT:0002244 name: turbinate morphology namespace: Trait.ontology def: "any structural anomaly of the small curved bones that extends horizontally along the lateral wall of the nasal passage" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal nasal concha" EXACT [] synonym: "abnormal turbinates" EXACT [] is_a: MT:0002233 ! nose morphology is_a: MT:0005274 ! viscerocranium morphology [Term] id: MT:0002245 name: ethmoid sinus morphology namespace: Trait.ontology def: "any structural anomaly of these small spaces found within the ethmoid bone" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal ethmoid sinus" EXACT [] is_a: MT:0002240 ! paranasal sinus morphology [Term] id: MT:0002246 name: frontal sinus morphology namespace: Trait.ontology def: "any structural anomaly of these paired air spaces within the frontal bone" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal frontal sinus" EXACT [] is_a: MT:0002240 ! paranasal sinus morphology [Term] id: MT:0002247 name: maxillary sinus morphology namespace: Trait.ontology def: "any structural anomaly of the air space located within the maxilla, and which opens to the middle meatus of the nasal cavity" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal maxillary sinus" EXACT [] is_a: MT:0002240 ! paranasal sinus morphology [Term] id: MT:0002248 name: sphenoid sinus morphology namespace: Trait.ontology def: "any structural anomaly of the air space located within the sphenoid bone, and which opens to the highest meatus of the nasal cavity" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal sphenoid sinus" EXACT [] is_a: MT:0002240 ! paranasal sinus morphology [Term] id: MT:0002249 name: larynx morphology namespace: Trait.ontology def: "any structural anomaly of the most superior portion of the respiratory tract" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Pathology_2nd edition:ISBN 0-397-51047-0] comment: the larynx is specialized for vocalization and is bounded above by the pharynx and oral cavity, and below byt the first tracheal ring is_a: MT:0002132 ! respiratory system morphology [Term] id: MT:0002250 name: hypopharynx morphology namespace: Trait.ontology def: "structural anomaly in the portion of the pharynx that lies below the upper edge of the epiglottis and opens into the larynx and the esophagus" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "hypopharynx abnormalities" EXACT [] is_a: MT:0002234 ! pharynx morphology [Term] id: MT:0002251 name: nasopharynx morphology namespace: Trait.ontology def: "structural anomaly of the section of the pharynx that lies above the soft palate" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "nasopharynx abnormalities" EXACT [] is_a: MT:0002234 ! pharynx morphology [Term] id: MT:0002252 name: oropharynx morphology namespace: Trait.ontology def: "structural anomaly of the portion of the pharynx that lies between the soft palate and the upper edge of the epiglottis" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] is_a: MT:0002234 ! pharynx morphology [Term] id: MT:0002253 name: pharyngeal muscle morphology namespace: Trait.ontology def: "structural anomaly of any of the muscles of the pharynx, the inferior, middle and superior constrictors, salpingopharyngeus, and stylopharyngeus" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] synonym: "pharyngeal muscle abnormalities" EXACT [] is_a: MT:0000759 ! skeletal muscle morphology is_a: MT:0002234 ! pharynx morphology [Term] id: MT:0002254 name: reproductive system inflammation namespace: Trait.ontology def: "local accumulation of fluid, plasma proteins, and leukocytes in any of the reproductive organs" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] is_a: MT:0001846 ! tissue specific inflammatory response is_a: MT:0001919 ! reproductive system physiology [Term] id: MT:0002255 name: glottis morphology namespace: Trait.ontology def: "any structural anomaly of the vocal apparatus of the larynx, which includes the vocal cords and the opening between them" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Pathology_2nd edition:ISBN 0-397-51047-0] synonym: "abnormal glottis" EXACT [] is_a: MT:0002249 ! larynx morphology [Term] id: MT:0002256 name: laryngeal cartilage morphology namespace: Trait.ontology def: "any structural anomaly of the cartilaginous structures that support the larynx" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Pathology_2nd edition:ISBN 0-397-51047-0] synonym: "abnormal laryngeal cartilage" EXACT [] is_a: MT:0000163 ! cartilage morphology is_a: MT:0002249 ! larynx morphology [Term] id: MT:0002257 name: arytenoid cartilage morphology namespace: Trait.ontology def: "any structural anomaly of the paired triangular cartilages located postlaterally at the level of the thyroid cartilage" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Pathology_2nd edition:ISBN 0-397-51047-0] comment: the vocal cords are attached to the arytenoid cartilages; their movement facilitates the vibration of the vocal cords synonym: "abnormal arytenoid cartilage" EXACT [] is_a: MT:0002256 ! laryngeal cartilage morphology [Term] id: MT:0002258 name: cricoid cartilage morphology namespace: Trait.ontology def: "any structural anomaly of the most inferior of the laryngeal cartilages" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Pathology_2nd edition:ISBN 0-397-51047-0] synonym: "abnormal cricoid cartilage" EXACT [] is_a: MT:0002256 ! laryngeal cartilage morphology [Term] id: MT:0002259 name: epiglottis morphology namespace: Trait.ontology def: "any structural anomaly of the most superior of the laryngeal cartilages, which is found at the root of the tongue and folds back over the entrance to the larynx during swallowing" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Pathology_2nd edition:ISBN 0-397-51047-0] synonym: "abnormal epiglottis" EXACT [] is_a: MT:0002256 ! laryngeal cartilage morphology [Term] id: MT:0002260 name: thyroid cartilage morphology namespace: Trait.ontology def: "any structural anomaly of the largest of the laryngeal cartilages" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Pathology_2nd edition:ISBN 0-397-51047-0] comment: the thyroid cartilage consists of two fused plates; their point of fusion is the "Adam's apple" synonym: "abnormal thyroid cartilage" EXACT [] is_a: MT:0002256 ! laryngeal cartilage morphology [Term] id: MT:0002261 name: laryngeal mucosa morphology namespace: Trait.ontology def: "any structural anomaly of the mucous lining of the larynx, which is composed of squamous epithelium in the upper larynx and ciliated columnar epithelium in the lower larynx" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Pathology_2nd edition:ISBN 0-397-51047-0] synonym: "abnormal laryngeal mucosa" EXACT [] is_a: MT:0002249 ! larynx morphology is_a: MT:0002277 ! respiratory mucosa morphology [Term] id: MT:0002262 name: nasal mucosa goblet cell morphology namespace: Trait.ontology def: "any structural abnormality of the cells lining the nasal epithelium that produce and secrete mucins" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal goblet cells of the nasal mucosa" EXACT [] synonym: "abnormal nasal mucous membrane" EXACT [] is_a: MT:0002238 ! nasal mucosa morphology [Term] id: MT:0002263 name: laryngeal muscle morphology namespace: Trait.ontology def: "any structural anomaly of the muscles associated with the larynx" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings, Pathology_2nd edition:ISBN 0-397-51047-0] synonym: "abnormal laryngeal muscles" EXACT [] is_a: MT:0000759 ! skeletal muscle morphology is_a: MT:0002249 ! larynx morphology [Term] id: MT:0002264 name: bronchus morphology namespace: Trait.ontology def: "any structural anomaly of the upper conducting airways of the lung; these airways arise from the terminus of the trachea" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings, Pathology_2nd edition:ISBN 0-397-51047-0] comment: the bronchi contain both cartilage and mucous glands in their walls synonym: "abnormal bronchi" EXACT [] is_a: MT:0004391 ! respiratory conducting tube [Term] id: MT:0002265 name: left major bronchus morphology namespace: Trait.ontology def: "any structural anomaly of the conducting airway leading to the left lobe of the lungs" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Pathology_2nd edition:ISBN 0-397-51047-0] synonym: "abnormal left major bronchus" EXACT [] is_a: MT:0002264 ! bronchus morphology [Term] id: MT:0002266 name: right major bronchus morphology namespace: Trait.ontology def: "any structural anomaly of the conducting airway leading to the right lobe of the lungs" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Pathology_2nd edition:ISBN 0-397-51047-0] synonym: "abnormal right major bronchus" EXACT [] is_a: MT:0002264 ! bronchus morphology [Term] id: MT:0002267 name: bronchiole morphology namespace: Trait.ontology def: "any structural anomaly of the conducting airway of the lungs found terminal to the bronchi; these structures contain neither cartilage nor mucous-secreting glands; the epithelium of the bronchioles becomes thinner with each branching" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Pathology_2nd edition:ISBN 0-397-51047-0] synonym: "abnormal bronchioles" EXACT [] is_a: MT:0004391 ! respiratory conducting tube [Term] id: MT:0002268 name: terminal bronchiole morphology namespace: Trait.ontology def: "any structural anomaly of the last conducting structure of non-respiratory bronchioles; after this point, the airways have alveoli in their walls" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Pathology_2nd edition:ISBN 0-397-51047-0] synonym: "abnormal terminal bronchioles" EXACT [] is_a: MT:0002267 ! bronchiole morphology [Term] id: MT:0002269 name: muscle size namespace: Trait.ontology def: "a wasting of muscle tissue resulting in a derangement of the muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [cml:Cathleen M. Lutz_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] subset: slim_cattle subset: slim_chkn subset: slim_pig synonym: "muscle atrophy" EXACT [] is_a: MT:0002108 ! muscle morphology [Term] id: MT:0002270 name: respiratory alveoli morphology namespace: Trait.ontology def: "any structural anomaly of the small sac-like dilations of the distal airspace of the lung; they are present along the walls of the alveolar sacs, alveolar ducts and terminal bronchioles; gas exchange of oxygen and carbon dioxide between alveolar air and blood in the pulmonary capillaries takes place across the cell walls" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] synonym: "abnormal alveoli" EXACT [] synonym: "abnormal pulmonary alveoli morphology" EXACT [] is_a: MT:0001175 ! lung morphology [Term] id: MT:0002271 name: respiratory alveolar duct morphology namespace: Trait.ontology def: "any structural anomaly of the respiratory conducting tubes distal to the respiratory bronchiole that lead to the alveolar sacs and the alveoli" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal alveolar ducts" EXACT [] is_a: MT:0004391 ! respiratory conducting tube [Term] id: MT:0002272 name: nervous system electrophysiology namespace: Trait.ontology alt_id: MT:0002677 def: "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "abnormal electrophysiology" EXACT [] synonym: "electrophysiology abnormalities" EXACT [] synonym: "PNS electrophysiology abnormalities" NARROW [] is_a: MT:0003633 ! nervous system physiology [Term] id: MT:0002273 name: respiratory alveolar epithelial cell morphology namespace: Trait.ontology def: "any structural anomaly of the cells lining the alveoli" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "abnormal alveolar epithelial cells" EXACT [] synonym: "abnormal lung epithelial cells" EXACT [] is_a: MT:0002270 ! respiratory alveoli morphology [Term] id: MT:0002274 name: type I pneumocyte morphology namespace: Trait.ontology def: "any structural anomaly of the epithelial cells lining the alveoli through which gas exchange occurs; these are thin cells with a large surface area" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Pathology_2nd edition:ISBN 0-397-51047-0] synonym: "abnormal type I cells" EXACT [] synonym: "abnormal type I pneumocytes" EXACT [] is_a: MT:0002273 ! respiratory alveolar epithelial cell morphology [Term] id: MT:0002275 name: type II pneumocyte morphology namespace: Trait.ontology def: "any structural anomaly of the epithelial cells lining the alveoli that produce surfactant" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Pathology_2nd edition:ISBN 0-397-51047-0] synonym: "abnormal type II cells" EXACT [] synonym: "abnormal type II pneumocytes" EXACT [] is_a: MT:0002273 ! respiratory alveolar epithelial cell morphology [Term] id: MT:0002276 name: lung interstitium morphology namespace: Trait.ontology def: "any structural anomaly of the lung tissue, but not including the conducting airways (bronchi, bronchioles, alveoli)" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Pathology_2nd edition:ISBN 0-397-51047-0] synonym: "abnormal lung interstitium" EXACT [] synonym: "abnormal pulmonary interstitium" EXACT [] is_a: MT:0001175 ! lung morphology [Term] id: MT:0002277 name: respiratory mucosa morphology namespace: Trait.ontology def: "structural anomaly of the mucous membrane lining the respiratory tract" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] subset: slim_pig synonym: "abnormal respiratory mucosa" EXACT [] is_a: MT:0002132 ! respiratory system morphology [Term] id: MT:0002278 name: respiratory muscle morphology namespace: Trait.ontology def: "structural anomaly of any of the muscles involved in breathing" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] subset: slim_cattle subset: slim_pig is_a: MT:0002132 ! respiratory system morphology [Term] id: MT:0002279 name: diaphragm morphology namespace: Trait.ontology alt_id: MT:0000760 def: "structural defect in the thin musculomebranous barrier that separates the abdominal and thoracic cavities; these muscles often used for breathing control" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] subset: slim_pig synonym: "abnormal diaphragm muscle" EXACT [] is_a: MT:0002278 ! respiratory muscle morphology is_a: MT:0003358 ! hypaxial muscle morphology [Term] id: MT:0002280 name: intercostal muscle morphology namespace: Trait.ontology def: "anomaly in the respiratory muscles that arise from the lower border of one rib and insert into the upper border of the adjoining rib" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] subset: slim_cattle synonym: "abnormal intercostal muscles" EXACT [] is_a: MT:0002278 ! respiratory muscle morphology is_a: MT:0003358 ! hypaxial muscle morphology [Term] id: MT:0002281 name: respiratory mucosa goblet cell morphology namespace: Trait.ontology def: "structural anomaly of the cells of the respiratory epithelial lining that produce and secrete mucins" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0002277 ! respiratory mucosa morphology [Term] id: MT:0002282 name: trachea morphology namespace: Trait.ontology def: "structural anomaly of the tube descending from the larynx and branching into the right and left main bronchi" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0002132 ! respiratory system morphology [Term] id: MT:0002284 name: tracheal smooth muscle morphology namespace: Trait.ontology def: "structural anomaly of the smooth muscle lining the trachea" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Pathology:ISBN 0-397-51047-0] is_a: MT:0000767 ! smooth muscle morphology is_a: MT:0002282 ! trachea morphology [Term] id: MT:0002285 name: tracheal ciliated epithelium morphology namespace: Trait.ontology def: "structural anomaly of the epithelial lining of the trachea which contains numerous ciliated cells" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Pathology:ISBN 0-397-51047-0] is_a: MT:0002282 ! trachea morphology [Term] id: MT:0002286 name: cryptorchism namespace: Trait.ontology def: "failure of one or both of the testes to descend into the scrotum around the time of birth" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] synonym: "cryptorchidism" EXACT [] synonym: "undescended testes" EXACT [] is_a: MT:0001146 ! testis morphology [Term] id: MT:0002292 name: gestational length namespace: Trait.ontology def: "anomaly in the usual duration of time between when a fertilized egg implants in the wall of the uterus and the birth of offspring" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] subset: slim_cattle subset: slim_pig is_a: MT:0003699 ! female reproductive system physiology [Term] id: MT:0002295 name: pulmonary circulation namespace: Trait.ontology alt_id: MT:0001941 def: "flow of blood through the lungs" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] synonym: "respiratory circulation" EXACT [] is_a: MT:0002128 ! blood circulation is_a: MT:0002133 ! respiratory system physiology [Term] id: MT:0002296 name: aspiration namespace: Trait.ontology def: "inspiration into the airways of fluid or any foreign material " [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002314 ! respiratory mechanics [Term] id: MT:0002297 name: forced expiratory flow rates namespace: Trait.ontology def: "anomaly in the rates of airflow during forced vital capacity determination" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0002327 ! respiratory function [Term] id: MT:0002304 name: total lung capacity namespace: Trait.ontology def: "anomaly in the volume of air contained in the lungs at the end of maximal inspiration" [MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0001942 ! lung volume is_a: MT:0002314 ! respiratory mechanics [Term] id: MT:0002306 name: functional residual capacity namespace: Trait.ontology def: "anomaly in the volume of air remaining in the lungs at the end of a normal expiration" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0002304 ! total lung capacity [Term] id: MT:0002308 name: residual volume namespace: Trait.ontology def: "anomaly in the volume of air remaining in the lungs at the end of maximal expiration" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0002306 ! functional residual capacity [Term] id: MT:0002309 name: vital capacity namespace: Trait.ontology def: "anomaly in the amount of air that is exhaled by a maximal expiration following a maximal inspiration" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0002304 ! total lung capacity [Term] id: MT:0002310 name: susceptibility to fatty liver development namespace: Trait.ontology def: "less likely than normal to develop hepatic steatosis " [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] is_a: MT:0002628 ! fatty liver [Term] id: MT:0002311 name: inspiratory capacity namespace: Trait.ontology def: "anomaly in the maximal volume of air that can be inspired after the end of a normal expiration" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0002309 ! vital capacity [Term] id: MT:0002312 name: inspiratory reserve volume namespace: Trait.ontology def: "anomaly in the extra volume of air that can be inspired with maximal effort after reaching the end of a normal inspiration" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0002311 ! inspiratory capacity [Term] id: MT:0002313 name: tidal volume namespace: Trait.ontology def: "anomaly in the volume of air inspired or expired during each normal respiratory cycle" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0002311 ! inspiratory capacity [Term] id: MT:0002314 name: respiratory mechanics namespace: Trait.ontology def: "anomaly in the action of the lungs, diaphragm, ribs and chest wall during respiration" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0001943 ! respiration [Term] id: MT:0002315 name: respiratory signs/symptoms namespace: Trait.ontology def: "manifestations of diseases of the respiratory tract " [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0001943 ! respiration [Term] id: MT:0002317 name: dyspnea namespace: Trait.ontology def: "shortness of breath; distress in breathing " [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "gasping" EXACT [] is_a: MT:0001951 ! breathing [Term] id: MT:0002320 name: alveolar ventilation namespace: Trait.ontology def: "increased alveolar ventilation relative to metabolic carbon dioxide production; results in carbon dioxide pressure decreasing below normal" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002315 ! respiratory signs/symptoms is_a: MT:0002338 ! pulmonary ventilation [Term] id: MT:0002322 name: respiratory transport namespace: Trait.ontology def: "anomaly in the process of gas exchange" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0001943 ! respiration [Term] id: MT:0002323 name: susceptibility to induced hyperlipidemia namespace: Trait.ontology def: "less likely than normal to develop abnormally high levels of circulating lipids" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] is_a: MT:0002118 ! lipid homeostasis [Term] id: MT:0002324 name: blood-air barrier namespace: Trait.ontology def: "anomaly in the membrane between the capillary blood and alveolar air, comprised of the alveolar epithelium and the capillary epithelium and their adherent basement membranes and epithelial cell cytoplasm " [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0001175 ! lung morphology is_a: MT:0002336 ! pulmonary gas exchange [Term] id: MT:0002325 name: pulmonary diffusing capacity namespace: Trait.ontology def: "anomaly in the amount of gas taken up by pulmonary capillary blood per minute per unit of average oxygen pressure gradient between alveolar gas and pulmonary capillary blood" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0002336 ! pulmonary gas exchange [Term] id: MT:0002326 name: ventilation-perfusion ratio namespace: Trait.ontology def: "ratio of alveolar ventilation to simultaneous capillary blood flow in the lung" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] comment: changes in this ratio alter the amount of O2 or CO2 in the blood is_a: MT:0002295 ! pulmonary circulation is_a: MT:0002336 ! pulmonary gas exchange is_a: MT:0002338 ! pulmonary ventilation [Term] id: MT:0002327 name: respiratory function namespace: Trait.ontology def: "anomaly in any measure of the processes involved in respiration" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] is_a: MT:0001943 ! respiration [Term] id: MT:0002328 name: airway resistance namespace: Trait.ontology def: "anomaly in the opposition to flow of air caused by the forces of friction, measured as the ratio of driving pressure to the rate of air flow" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0002314 ! respiratory mechanics is_a: MT:0002327 ! respiratory function [Term] id: MT:0002329 name: blood gas level namespace: Trait.ontology def: "anomaly in the amount of oxygen and carbon dioxide in the blood" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0003948 ! gas homeostasis [Term] id: MT:0002330 name: bronchial provocation namespace: Trait.ontology def: "anomaly in the results of measures of responsiveness to allergens, pharmacological solutions, or control solutions" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] comment: used in asthma diagnosis is_a: MT:0002327 ! respiratory function [Term] id: MT:0002332 name: exercise endurance namespace: Trait.ontology def: "improved or impaired performance during controlled physical activity" [MeSH:National Library of Medicine_Medical Subject Headings, smb:Susan M. Bello_Mouse Genome Informatics Curator] synonym: "abnormal exercise fitness" EXACT [] synonym: "abnormal exercise tests" EXACT [] is_a: MT:0002121 ! metabolism [Term] id: MT:0002333 name: lung compliance namespace: Trait.ontology def: "anomalous pulmonary volume change per unit pressure change " [MeSH:National Library of Medicine_Medical Subject Headings] comment: this is a measure of the stiffness of the lung and indicative for diseases that cause fibrosis or edema in the lungs is_a: MT:0002314 ! respiratory mechanics is_a: MT:0002327 ! respiratory function [Term] id: MT:0002334 name: airway responsiveness namespace: Trait.ontology alt_id: MT:0002331 def: "anomalous response in bronchial provocation tests" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "abnormal methacholine challenge" EXACT [] is_a: MT:0002330 ! bronchial provocation [Term] id: MT:0002336 name: pulmonary gas exchange namespace: Trait.ontology def: "anomaly in the exchange of oxygen and carbon dioxide between the alveolar air and pulmonary capillary blood" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0002322 ! respiratory transport [Term] id: MT:0002337 name: whole-body plethysmography namespace: Trait.ontology def: "anomaly in the measurements gathered in a chamber that encloses the body and in which changes in volume are recorded" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002327 ! respiratory function [Term] id: MT:0002338 name: pulmonary ventilation namespace: Trait.ontology def: "anomaly in the total volume of gas per minute inspired or expired " [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0002314 ! respiratory mechanics [Term] id: MT:0002339 name: lymph node morphology namespace: Trait.ontology alt_id: MT:0000699 def: "anomalous structure, size, or cellularity of the oval or bean shaped bodies located along the lymphatic system" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal lymph node" EXACT [] synonym: "lymph node abnormalities" EXACT [] is_a: MT:0002722 ! immune system organ morphology [Term] id: MT:0002340 name: axillary lymph node morphology namespace: Trait.ontology def: "anomalous structure, development, or number of the lymph nodes located in the upper body" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "axillary lymph node abnormalities" EXACT [] is_a: MT:0002339 ! lymph node morphology [Term] id: MT:0002342 name: lymph node trabeculae namespace: Trait.ontology def: "anomaly of the supporting structure of the lymph node" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] is_a: MT:0005024 ! lymph node structure [Term] id: MT:0002343 name: lymph node cortex morphology namespace: Trait.ontology def: "anomaly in the outer area of the lymph node that has B and T cell domains" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] is_a: MT:0005024 ! lymph node structure [Term] id: MT:0002344 name: lymph node B cell domain morphology namespace: Trait.ontology def: "anomaly in the lymph node cortex in which B lymphocytes reside" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Pathology:ISBN 0-397-51047-0] synonym: "abnormal B cell dependent cortex" EXACT [] synonym: "abnormal B-cell domain" EXACT [] synonym: "abnormal lymph node germinal center" EXACT [] is_a: MT:0002343 ! lymph node cortex morphology [Term] id: MT:0002345 name: lymph node primary follicle morphology namespace: Trait.ontology def: "anomaly in the immunologically inactive B cell area of the lymph node cortex" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Pathology:ISBN 0-397-51047-0] comment: cells in the primary follicle consist of cohesive aggregates of small, normal-appearing lymphocytes is_a: MT:0002344 ! lymph node B cell domain morphology [Term] id: MT:0002346 name: lymph node secondary follicle morphology namespace: Trait.ontology def: "anomaly in the immunologically active area of the lymph node cortex " [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Pathology:ISBN 0-397-51047-0] comment: cells size in the germinal centers varies synonym: "abnormal germinal centers" EXACT [] is_a: MT:0002344 ! lymph node B cell domain morphology [Term] id: MT:0002347 name: lymph node T cell domain morphology namespace: Trait.ontology def: "anomaly in the area of the lymph node in which T lymphocytes reside" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7, Pathology:ISBN 0-397-51047-0] synonym: "abnormal T cell dependent paracortex" EXACT [] synonym: "abnormal T-cell domain" EXACT [] synonym: "deep cortex" EXACT [] is_a: MT:0002343 ! lymph node cortex morphology [Term] id: MT:0002348 name: lymph node medulla morphology namespace: Trait.ontology def: "anomaly in the area of the lymph node through which lymph leaves the node; it contains macrophages and antibody-secreting plasma cells" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] synonym: "abnormal medullary sinus" EXACT [] is_a: MT:0005024 ! lymph node structure [Term] id: MT:0002349 name: afferent lymphatic vessel morphology namespace: Trait.ontology def: "structural anomaly in the tube entering the lymph node" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] is_a: MT:0001879 ! lymphatic vessel morphology is_a: MT:0005024 ! lymph node structure [Term] id: MT:0002350 name: efferent lymphatic vessel morphology namespace: Trait.ontology def: "structural anomaly in the tube exiting the lymph node" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] is_a: MT:0001879 ! lymphatic vessel morphology is_a: MT:0005024 ! lymph node structure [Term] id: MT:0002351 name: cervical lymph node morphology namespace: Trait.ontology def: "anomalous structure, development, or number of the lymph nodes found near the neck and shoulders" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] synonym: "cervical lymph node abnormalities" EXACT [] is_a: MT:0002339 ! lymph node morphology [Term] id: MT:0002352 name: popliteal lymph node morphology namespace: Trait.ontology def: "anomalous structure, development, or number of the lymph nodes which drain the legs" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "popliteal lymph node abnormalities" EXACT [] is_a: MT:0002339 ! lymph node morphology [Term] id: MT:0002353 name: inguinal lymph node morphology namespace: Trait.ontology def: "anomalous structure, development, or number of the lymph nodes located in the groin area" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] synonym: "inguinal lymph node abnormalities" EXACT [] is_a: MT:0002339 ! lymph node morphology [Term] id: MT:0002354 name: spleen trabecular artery integrity namespace: Trait.ontology def: "any measurable characteristic pertaining to the the structural completeness or structural soundness of one of the branches of the splenic artery" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] is_a: MT:0000689 ! spleen morphology is_a: MT:0003410 ! artery integrity [Term] id: MT:0002356 name: spleen red pulp morphology namespace: Trait.ontology def: "anomalous structure of the area of the spleen that screens and eliminates defective or foreign cells" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Pathology:ISBN 0-397-51047-0] is_a: MT:0000689 ! spleen morphology [Term] id: MT:0002357 name: spleen white pulp morphology namespace: Trait.ontology def: "anomalous structure or formation of the splenic area consisting of lymph nodules and diffuse lymphatic tissue" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] is_a: MT:0000689 ! spleen morphology [Term] id: MT:0002358 name: spleen periarteriolar lymphoid sheath morphology namespace: Trait.ontology def: "anomalous structure of the area of the spleen in which T cells surround the central arteriole" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7, Pathology:ISBN 0-397-51047-0] synonym: "abnormal PALS" EXACT [] synonym: "abnormal T cell domain of the splenic white pulp" EXACT [] is_a: MT:0002357 ! spleen white pulp morphology [Term] id: MT:0002359 name: spleen germinal center morphology namespace: Trait.ontology def: "anomalous structure or formation of the area of the spleen in which activated follicles are located" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Pathology:ISBN 0-397-51047-0] is_a: MT:0002357 ! spleen white pulp morphology [Term] id: MT:0002360 name: spleen B cell corona morphology namespace: Trait.ontology def: "anomalous structure of the area of the splenic white pulp dominated by B lymphocyte follicles" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Pathology:ISBN 0-397-51047-0] synonym: "abnormal B cell domain of the spleen" EXACT [] synonym: "abnormal spleen B-cell corona" EXACT [] is_a: MT:0002357 ! spleen white pulp morphology [Term] id: MT:0002361 name: spleen central arteriole morphology namespace: Trait.ontology def: "anomalous structure of the blood vessel within the spleen that connects the trabecular artery to the trabecular vein" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] is_a: MT:0002357 ! spleen white pulp morphology [Term] id: MT:0002362 name: spleen marginal zone morphology namespace: Trait.ontology def: "anomalous structure of the area surrounding the marginal sinus and containing lymphocytes" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] is_a: MT:0000689 ! spleen morphology [Term] id: MT:0002363 name: spleen marginal sinus morphology namespace: Trait.ontology def: "anomalous structure of the area of the spleen through which blood enters" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] is_a: MT:0000689 ! spleen morphology [Term] id: MT:0002364 name: thymus size namespace: Trait.ontology def: "deviation from the normal size of the thymus" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] is_a: MT:0000703 ! thymus morphology is_a: MT:0002221 ! lymph organ size [Term] id: MT:0002365 name: thymus cellularity namespace: Trait.ontology def: "anomaly in the cellular makeup of the thymus" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] is_a: MT:0000703 ! thymus morphology is_a: MT:0002222 ! lymph organ cellularity [Term] id: MT:0002367 name: thymus lobule morphology namespace: Trait.ontology def: "anomalous structure or development of the basic structural unit of the thymus" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Pathology:ISBN 0-397-51047-0] synonym: "abnormal thymus lobule" EXACT [] is_a: MT:0000703 ! thymus morphology [Term] id: MT:0002368 name: thymus capsule morphology namespace: Trait.ontology def: "anomalous structure or development of the fibrous connective tissue surrounding the thymus" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "abnormal thymus capsule" EXACT [] is_a: MT:0000703 ! thymus morphology [Term] id: MT:0002369 name: thymus subcapsular epithelium morphology namespace: Trait.ontology def: "anomalous structure or development of the epithelial cells lining the capsule and trabeculae of the thymus" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] synonym: "abnormal subcapsular epithelium of the thymus" EXACT [] is_a: MT:0002368 ! thymus capsule morphology [Term] id: MT:0002370 name: thymus trabeculae morphology namespace: Trait.ontology def: "anomalous structure or development of the thymic connective tissue which extends into the parenchyma" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Pathology:ISBN 0-397-51047-0] is_a: MT:0000703 ! thymus morphology [Term] id: MT:0002371 name: thymus cortex morphology namespace: Trait.ontology def: "anomalous structure or development of the outer area of thymus lobules" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] comment: the cortex contains immature thymocytes, cortical epithelial cells, and scattered macrophages synonym: "abnormal thymus cortex" EXACT [] is_a: MT:0002367 ! thymus lobule morphology [Term] id: MT:0002375 name: thymus medulla morphology namespace: Trait.ontology def: "anomalous structure or development of the inner area of thymus lobules" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] comment: the medulla contains mature thymocytes, medualla epithelial cells, macrophages and dendritic cells synonym: "abnormal thymus medulla" EXACT [] is_a: MT:0002367 ! thymus lobule morphology [Term] id: MT:0002376 name: dendritic cell physiology namespace: Trait.ontology def: "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [J:85808, MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal dendritic cell function" EXACT [] synonym: "abnormal interdigitating reticular cell" EXACT [] is_a: MT:0001819 ! immune cell physiology [Term] id: MT:0002377 name: mucosa-associated lymphoid tissue morphology namespace: Trait.ontology def: "anomalous structure or development of the regional immune system associated with the mucosa" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] synonym: "MALT abnormalities" EXACT [] synonym: "mucosa-associated lymphoid tissue abnormalities" EXACT [] is_a: MT:0002722 ! immune system organ morphology [Term] id: MT:0002378 name: gut-associated lymphoid tissue morphology namespace: Trait.ontology def: "anomalous structure or development of the regional immune system located in the gut" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] synonym: "GALT abnormalities" EXACT [] synonym: "gut-associated lymphoid tissue abnormalities" EXACT [] is_a: MT:0002722 ! immune system organ morphology [Term] id: MT:0002379 name: oropharyngeal lymphoid tissue morphology namespace: Trait.ontology def: "anomalous structure or development of the circular lymphoid tissue formed by the lingual, pharyngeal, and faucial tonsils" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "abnormal oropharyngeal lymphoid tissue" EXACT [] synonym: "abnormal Waldeyer's ring" EXACT [] is_a: MT:0002377 ! mucosa-associated lymphoid tissue morphology [Term] id: MT:0002380 name: tonsil morphology namespace: Trait.ontology def: "anomalous structure or development of either of the two small almond-shaped masses of lymph tissue found on either side of the oropharynx" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "abnormal palatine tonsils" EXACT [] is_a: MT:0002379 ! oropharyngeal lymphoid tissue morphology [Term] id: MT:0002384 name: nasopharyngeal tonsil morphology namespace: Trait.ontology def: "anomalous structure or development of the lymph tissue in the roof and posterior wall of the nasopharynx" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "abnormal adenoids" EXACT [] is_a: MT:0002379 ! oropharyngeal lymphoid tissue morphology [Term] id: MT:0002385 name: lingual tonsillar tissue morphology namespace: Trait.ontology def: "anomalous structure or development of the lymph tissue on the floor of the oropharyngeal passage, near the root of the tongue" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "abnormal lingual tonsillar tissue" EXACT [] is_a: MT:0002379 ! oropharyngeal lymphoid tissue morphology [Term] id: MT:0002386 name: tubal tonsil morphology namespace: Trait.ontology def: "anomalous structure or development of the lymph tissue associated with the pharyngeal opening of the auditory tube" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] is_a: MT:0002379 ! oropharyngeal lymphoid tissue morphology [Term] id: MT:0002387 name: prevalence of Peyer's patches namespace: Trait.ontology def: "the distribution and/or number of Peyer's patches " [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] is_a: MT:0000696 ! Peyer's patch morphology [Term] id: MT:0002388 name: Peyer's patch epithelium morphology namespace: Trait.ontology def: "anomalous structure of the specialized epithelium of the Peyer's patch " [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] comment: antigen normally enters the Peyer's patch via this specialized epithelium synonym: "abnormal M cells" EXACT [] is_a: MT:0000696 ! Peyer's patch morphology [Term] id: MT:0002389 name: Peyer's patch follicle morphology namespace: Trait.ontology def: "anomaly of the structure, development, or size of the Peyer's patch normally occupied by B cells" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] is_a: MT:0000696 ! Peyer's patch morphology [Term] id: MT:0002391 name: Peyer's patch germinal center morphology namespace: Trait.ontology def: "anomalous structure or differentiation of the area of the Peyer's patch where B cells proliferate and differentiate into plasma cells" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] is_a: MT:0000696 ! Peyer's patch morphology [Term] id: MT:0002392 name: Peyer's patch T cell area namespace: Trait.ontology def: "anomalous structure or development of the Peyer's patch normally occupied by T lymphocytes" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] synonym: "abnormal Peyer's patch T-cell area" EXACT [] is_a: MT:0000696 ! Peyer's patch morphology [Term] id: MT:0002393 name: bronchus-associated lymphoid tissue morphology namespace: Trait.ontology def: "anomalous structure or development of the regional immune system located near the bronchus" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] synonym: "BALT abnormalities" EXACT [] synonym: "bronchial-associated lymphoid tissue abnormalities" EXACT [] synonym: "bronchus-associated lymphoid tissue abnormalities" EXACT [] is_a: MT:0002722 ! immune system organ morphology [Term] id: MT:0002396 name: hematopoietic system morphology/development namespace: Trait.ontology def: "any structural or developmental anomaly of the blood cells or the organs associated with the development and formation of blood cells" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] subset: slim_cattle subset: slim_chkn subset: slim_pig synonym: "abnormal blood morphology" EXACT [] synonym: "abnormal hemopoietic system morphology/development" EXACT [] synonym: "hematopoietic organ abnormalities" EXACT [] is_a: MT:0005397 ! hematopoietic system trait [Term] id: MT:0002397 name: bone marrow morphology namespace: Trait.ontology def: "structural anomalies in the soft tissue that fills the cavities of bones" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "bone marrow abnormalities" EXACT [] is_a: MT:0003795 ! bone structure [Term] id: MT:0002398 name: bone marrow cell morphology/development namespace: Trait.ontology def: "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] subset: slim_pig synonym: "bone marrow cell abnormalities" EXACT [] is_a: MT:0002396 ! hematopoietic system morphology/development [Term] id: MT:0002399 name: pluripotent precursor cell morphology/development namespace: Trait.ontology def: "anomalous structure or formation of the cells that give rise to most types of cells necessary for fetal development" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] synonym: "pluripotent stem cell abnormalities" EXACT [] is_a: MT:0002085 ! embryonic tissue morphology [Term] id: MT:0002400 name: multipotent stem cell morphology/development namespace: Trait.ontology def: "anomalies of the specialized cells that are committed to giving rise to cells with particular functions" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0002399 ! pluripotent precursor cell morphology/development [Term] id: MT:0002401 name: lymphopoiesis namespace: Trait.ontology alt_id: MT:0000310 alt_id: MT:0001640 alt_id: MT:0001880 def: "atypical formation of lymphocytes and plasma cells from lymphoid stem cells which develop from the pluripotent hematopoietic stem cells in the bone marrow; these lymphoid stem cells differentiate into T-lymphocytes; B-lymphocytes; plasma cells; or NK-cells (natural killer cells), depending on the organ or tissues to which they migrate" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] subset: slim_pig synonym: "abnormal lymphopoiesis" EXACT [] synonym: "lymphoid stem cell abnormalities" EXACT [] synonym: "lymphopoiesis abnormalities" EXACT [] is_a: MT:0005460 ! leukopoiesis [Term] id: MT:0002403 name: pre-B cell morphology/development namespace: Trait.ontology def: "anomalous structure, development, or number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] comment: these cells express the mu heavy chain in both the cytoplasm and on the cell surface; in addition to the mu heavy chain, other cell surface markers include: CD45R, MHC class II, CD19, CD20, CD38, CD40 synonym: "pre-B cell abnormalities" EXACT [] synonym: "pre-B-cell abnormalities" EXACT [] is_a: MT:0002144 ! B lymphocyte development [Term] id: MT:0002404 name: intestinal adenoma namespace: Trait.ontology def: "benign tumors of the small and large intestine" [pvb:Pierre Vanden Borre_Mouse Genome Informatics Curator] synonym: "intestinal adenomata" EXACT [] is_a: MT:0002815 ! adenoma [Term] id: MT:0002405 name: respiratory system inflammation namespace: Trait.ontology def: "local accumulation of fluid, plasma proteins, and leukocytes in the respiratory system" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] subset: slim_pig is_a: MT:0001846 ! tissue specific inflammatory response is_a: MT:0002133 ! respiratory system physiology [Term] id: MT:0002407 name: double-negative T cell morphology/development namespace: Trait.ontology def: "anomalous structure, development, or number of the subset of T cells found in the thymus that express neither CD4 nor CD8" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] comment: these are precursors to mature T cells; normally, they do not circulate, but are found in the thymus; they have not undergone rearrangement of the alpha and beta T cell receptor genes synonym: "CD4-CD8- T cell abnormalities" EXACT [] synonym: "double-negative T cell abnormalities" EXACT [] synonym: "double-negative T-cell abnormalities" EXACT [] is_a: MT:0002145 ! T lymphocyte development [Term] id: MT:0002408 name: double-positive T cell morphology/development namespace: Trait.ontology def: "anomalous development or number of the subset of T cells found in the thymus that express both CD4 and CD8" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] comment: these cells are precursors to mature T cells and are generally located in the thymus; during their development, the alpha and beta chains of the T cell receptor are rearranged and the receptor can be expressed synonym: "CD4+CD8+ T cell abnormalities" EXACT [] synonym: "double-positive T cell abnormalities" EXACT [] synonym: "double-positive T-cell abnormalities" EXACT [] is_a: MT:0002145 ! T lymphocyte development [Term] id: MT:0002410 name: susceptibility to viral infection namespace: Trait.ontology def: "reduced likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] subset: slim_pig synonym: "increased resistance to viral infection" EXACT [] is_a: MT:0001793 ! susceptibility to infection [Term] id: MT:0002411 name: susceptibility to bacterial infection namespace: Trait.ontology def: "reduced likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] subset: slim_cattle subset: slim_pig synonym: "increased resistance to bacterial infection" EXACT [] is_a: MT:0001793 ! susceptibility to infection [Term] id: MT:0002413 name: megakaryoblast morphology/development namespace: Trait.ontology def: "anomalous structure or development of the progenitor cells of the thrombocytic (platelet) line of cells" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "megakaryoblast abnormalities" EXACT [] is_a: MT:0002398 ! bone marrow cell morphology/development [Term] id: MT:0002414 name: myeloblast morphology/development namespace: Trait.ontology def: "anomalous structure, formation, or numbers of the cells found in the bone marrow that give rise to the granulocyte line of blood cells" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] subset: slim_pig synonym: "myeloblast abnormalities" EXACT [] is_a: MT:0002398 ! bone marrow cell morphology/development [Term] id: MT:0002415 name: neutrophil morphology/development namespace: Trait.ontology def: "anomalous structure, differentiation, or number of the granular leukocytes that have a three- to five-lobed nucleus and a cytoplasm that contains inconspicuous granules stainable by neutral dyes" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] subset: slim_pig synonym: "neutrophil abnormalities" EXACT [] is_a: MT:0002414 ! myeloblast morphology/development is_a: MT:0002441 ! granulocyte morphology/development [Term] id: MT:0002416 name: proerythroblast morphology/development namespace: Trait.ontology def: "anomalous structure, formation, or numbers of the immature, nucleated erythrocyte precursors that give rise to reticulocytes" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal erythroid progenitor morphology/development" EXACT [] synonym: "normoblast abnormalities" EXACT [] synonym: "proerythroblast abnormalities" EXACT [] is_a: MT:0002398 ! bone marrow cell morphology/development [Term] id: MT:0002417 name: megakaryocyte morphology/development namespace: Trait.ontology def: "anomalous structure or formation of the very large cells found in the bone marrow that release platelets" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "megakaryocyte abnormalities" EXACT [] is_a: MT:0002413 ! megakaryoblast morphology/development [Term] id: MT:0002419 name: innate immunity namespace: Trait.ontology def: "anomaly in the function of the early phase of the response to infection; normally, it is present at all times, does not increase with exposure to specific pathogens, and does not discriminate between pathogens" [Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] synonym: "innate immunity dysfunction" EXACT [] synonym: "natural immunity abnormalities" EXACT [] is_a: MT:0001790 ! immune system physiology [Term] id: MT:0002420 name: adaptive immunity namespace: Trait.ontology def: "anomaly in the function of the response of antigen-specific lymphocytes to antigen, including the development of immunological memory" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] subset: slim_pig synonym: "acquired immune response dysfunction" EXACT [] synonym: "adaptive immunity dysfunction" EXACT [] is_a: MT:0001790 ! immune system physiology [Term] id: MT:0002421 name: cell-mediated immunity namespace: Trait.ontology def: "abnormal function of any adaptive immune response in which T cells play a main role" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] comment: this encompasses all adaptive immunity that cannot be transferred to a naive recipient with serum antibody (the definition of humoral immunity) subset: slim_pig synonym: "cell-mediated immunity dysfunction" EXACT [] is_a: MT:0002420 ! adaptive immunity [Term] id: MT:0002422 name: basophil morphology/development namespace: Trait.ontology def: "anomalous structure, differentiation, or number of the granular leukocytes that are characterized by pale-staining, lobate nucleus and cytoplasm and contain dark-staining granules of varying size and are stained by basic dyes " [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] synonym: "basophil abnormalities" EXACT [] is_a: MT:0002414 ! myeloblast morphology/development is_a: MT:0002441 ! granulocyte morphology/development [Term] id: MT:0002423 name: mast cell physiology namespace: Trait.ontology def: "anomalous response of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal mast cell function" EXACT [] synonym: "mast cell abnormalities" EXACT [] is_a: MT:0001819 ! immune cell physiology [Term] id: MT:0002424 name: reticulocyte morphology/development namespace: Trait.ontology def: "anomalous structure, formation, or numbers of immature erythrocytes" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] synonym: "reticulocyte abnormalities" EXACT [] is_a: MT:0002416 ! proerythroblast morphology/development [Term] id: MT:0002425 name: susceptibility to autoimmune disorder namespace: Trait.ontology def: "likelihood that an organism will develop disease characterized by production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides" [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "autoimmune disorder susceptibility" EXACT [] synonym: "autoimmune disorders" EXACT [] is_a: MT:0001844 ! autoimmune response [Term] id: MT:0002427 name: dwarfism namespace: Trait.ontology def: "abnormally undersized with disproportionate body parts" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0003956 ! body size [Term] id: MT:0002428 name: semicircular canal namespace: Trait.ontology def: "anomaly of the organ of balance composed of three long bony tubes of the labyrinth" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0002729 ! canal morphology [Term] id: MT:0002429 name: blood cell morphology/development namespace: Trait.ontology alt_id: MT:0000178 alt_id: MT:0000205 alt_id: MT:0001576 alt_id: MT:0002545 def: "anomalous structure, differentiation, or number of any of the cells found in the blood" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] subset: slim_cattle subset: slim_chkn subset: slim_pig synonym: "blood cell abnormalities" EXACT [] synonym: "blood cell defects" EXACT [] is_a: MT:0002396 ! hematopoietic system morphology/development [Term] id: MT:0002432 name: CD4+ T cell morphology/development namespace: Trait.ontology def: "anomalous structure, differentiation, or number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "CD4+ T-cell abnormalities" EXACT [] synonym: "helper T cell abnormalities" EXACT [] is_a: MT:0002435 ! effector T cell morphology/development [Term] id: MT:0002433 name: T helper 1 morphology/development namespace: Trait.ontology def: "anomalous structure, formation, or numbers of the subset of helper T cells that enhance cell-mediated immune responses; these cells secrete IL-1 and gamma-IFN and are generally involved in inflammatory responses" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "T helper 1 abnormalities" EXACT [] synonym: "TH1 abnormalities" EXACT [] synonym: "Th1 abnormalities" EXACT [] is_a: MT:0002432 ! CD4+ T cell morphology/development [Term] id: MT:0002434 name: T helper 2 morphology/development namespace: Trait.ontology def: "anomalous structure, formation, or numbers of the subset of T helper cells that enhance humoral immunity and inhibit cell-mediated immune responses; these cells produce IL-4 and induce B cells to produce IgE and IgG1, while also supporting eosinophil and mast cell functions" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "T helper 2 abnormalities" EXACT [] synonym: "TH2 abnormalities" EXACT [] synonym: "Th2 abnormalities" EXACT [] is_a: MT:0002432 ! CD4+ T cell morphology/development [Term] id: MT:0002435 name: effector T cell morphology/development namespace: Trait.ontology def: "anomalous structure, formation, or numbers of the set of T lymphocytes that are able to respond immediately upon contact with cells bearing the appropriate peptide:MHC complex for the cell" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "abnormal single positive T cell" EXACT [] synonym: "effector T cell abnormalities" EXACT [] synonym: "effector T-cell abnormalities" EXACT [] is_a: MT:0002145 ! T lymphocyte development [Term] id: MT:0002436 name: cytotoxic T cell morphology/development namespace: Trait.ontology def: "anomalous structure, formation, or numbers of the subset of CD8+ T lymphocytes capable of directly killing appropriately targeted cells " [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] synonym: "CD8+ T cell abnormalities" EXACT [] synonym: "cytotoxic T cell abnormalities" EXACT [] synonym: "cytotoxic T-cell abnormalities" EXACT [] is_a: MT:0005010 ! CD8+ T cell morphology/development [Term] id: MT:0002437 name: suppressor T cell morphology/development namespace: Trait.ontology def: "anomalous structure, formation, or numbers of the subset of CD8+ lymphocytes that suppress antibody production or inhibit immune responses" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] synonym: "suppressor T cell abnormalities" EXACT [] synonym: "suppressor T-cell abnormalities" EXACT [] is_a: MT:0005010 ! CD8+ T cell morphology/development [Term] id: MT:0002439 name: plasma cell morphology/development namespace: Trait.ontology def: "anomalous structure, differentiation, or number of the specialized forms of B-lymphocytes which produce and secrete immunoglobulin" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] comment: these are terminally differentiated B cells and no longer respond to antigens or helper T cells; in addition, they no longer express surface Ig or surface MHC class II; they are tailored to secrete antibody at high rates synonym: "plasma cell abnormalities" EXACT [] is_a: MT:0002144 ! B lymphocyte development [Term] id: MT:0002440 name: memory B cell morphology/development namespace: Trait.ontology def: "anomalous structure, differentiation, or number of cells of the B lymphocyte lineage that do not secrete antibody after an initial contact with antigen, but can be rapidly activated after a second challenge with the same antigen" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] synonym: "memory B cell abnormalities" EXACT [] synonym: "memory B-cell abnormalities" EXACT [] is_a: MT:0002144 ! B lymphocyte development [Term] id: MT:0002441 name: granulocyte morphology/development namespace: Trait.ontology def: "anomalous structure, differentiation, or number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] subset: slim_pig synonym: "granulocyte abnormalities" EXACT [] is_a: MT:0001601 ! myelopoiesis [Term] id: MT:0002442 name: leukocyte physiology namespace: Trait.ontology def: "abnormal function of any of the white blood cells (basophils, eosinophils, neutrophils, lymphocytes, or monocytes)" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] subset: slim_pig synonym: "leukocyte dysfunction" EXACT [] is_a: MT:0001819 ! immune cell physiology is_a: MT:0002420 ! adaptive immunity is_a: MT:0002421 ! cell-mediated immunity [Term] id: MT:0002443 name: eosinophil morphology/development namespace: Trait.ontology def: "anomalous structure, differentiation or number of the granular leukocytes having a two-lobed nucleus and cytoplasm containing coarse, round granules that are uniform in size and stainable by eosin" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] synonym: "eosinophil abnormalities" EXACT [] is_a: MT:0002414 ! myeloblast morphology/development is_a: MT:0002441 ! granulocyte morphology/development [Term] id: MT:0002444 name: T cell physiology namespace: Trait.ontology def: "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "abnormal T cell function" EXACT [] synonym: "abnormal T lymphocyte function" EXACT [] synonym: "t lymphocyte dysfunction" EXACT [] synonym: "T-cell dysfunction" EXACT [] is_a: MT:0003945 ! lymphocyte physiology [Term] id: MT:0002445 name: mononuclear leukocyte morphology/development namespace: Trait.ontology def: "anomalous structure, differentiation, or number of either of the mature lymphocytes or monocytes found in the blood" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] subset: slim_pig synonym: "mononuclear leukocyte abnormalities" EXACT [] is_a: MT:0002414 ! myeloblast morphology/development is_a: MT:0005460 ! leukopoiesis [Term] id: MT:0002446 name: macrophage morphology/development namespace: Trait.ontology def: "anomalous structure, number, or composition of the large mononuclear phagocytic cells found in most tissues of the body" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] synonym: "macrophage abnormalities" EXACT [] synonym: "mononuclear phagocyte abnormalities" EXACT [] is_a: MT:0002620 ! monocyte morphology/development [Term] id: MT:0002447 name: erythrocyte morphology namespace: Trait.ontology def: "structural anomaly of the fetal and adult cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "erythrocyte abnormalities" EXACT [] synonym: "red blood cell abnormalities" EXACT [] is_a: MT:0002124 ! red blood cell is_a: MT:0002424 ! reticulocyte morphology/development [Term] id: MT:0002449 name: immune cell development namespace: Trait.ontology def: "atypical formation of the cells of the immune system" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] subset: slim_pig synonym: "immune cell developmental abnormalities" EXACT [] is_a: MT:0000716 ! immune system cell morphology [Term] id: MT:0002450 name: lymph organ development namespace: Trait.ontology def: "anomaly in the process of morphological maturation of the organs of the lymph system" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "lymph organ developmental abnormalities" EXACT [] is_a: MT:0002722 ! immune system organ morphology [Term] id: MT:0002451 name: macrophage physiology namespace: Trait.ontology def: "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] synonym: "macrophage dysfunction" EXACT [] is_a: MT:0002442 ! leukocyte physiology [Term] id: MT:0002452 name: antigen presenting cell physiology namespace: Trait.ontology def: "impairment or abnormality of the function of cells involved in making antigen recognizable by lymphocytes" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "antigen presenting cell dysfunction" EXACT [] is_a: MT:0001835 ! antigen presentation is_a: MT:0002420 ! adaptive immunity is_a: MT:0002421 ! cell-mediated immunity [Term] id: MT:0002453 name: B lymphocyte antigen presentation namespace: Trait.ontology def: "impairment in the ability of B lymphocyte to process and/or present antigen" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] synonym: "B cell antigen presentation abnormalities" EXACT [] synonym: "lymphocyte antigen presentation dysfunction" EXACT [] is_a: MT:0002452 ! antigen presenting cell physiology [Term] id: MT:0002454 name: macrophage antigen presentation namespace: Trait.ontology def: "impairment of these phagocytic cells to process and present antigen to T lymphocytes" [Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] synonym: "macrophage antigen presentation dysfunction" EXACT [] is_a: MT:0002451 ! macrophage physiology is_a: MT:0002452 ! antigen presenting cell physiology [Term] id: MT:0002455 name: dendritic cell antigen presentation namespace: Trait.ontology def: "impairment of these specialized cells to process and present antigen to T lymphocytes" [Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] synonym: "dendritic cell antigen presentation dysfunction" EXACT [] is_a: MT:0002376 ! dendritic cell physiology is_a: MT:0002452 ! antigen presenting cell physiology [Term] id: MT:0002456 name: Langerhans cell antigen presentation namespace: Trait.ontology def: "impairment of phagocytic cells of the epidermis to display antigen for recognition by T lymphocytes" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] synonym: "interdigitating reticular cell antigen presentation dysfunction" EXACT [] synonym: "Langerhans cell antigen presentation dysfunction" EXACT [] is_a: MT:0002455 ! dendritic cell antigen presentation is_a: MT:0005362 ! Langerhans cell physiology [Term] id: MT:0002458 name: B cell number namespace: Trait.ontology def: "count of cells that are formed in the bone marrow, migrate to the peripheral lymphatic system, and mature into plasma cells or memory cells; these cells are involved in humoral immunity " [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "B lymphocyte number" EXACT [] synonym: "B-cell number" EXACT [] is_a: MT:0000717 ! lymphocyte number is_a: MT:0002144 ! B lymphocyte development [Term] id: MT:0002459 name: B cell physiology namespace: Trait.ontology def: "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] subset: slim_pig synonym: "B cell dysfunction" EXACT [] synonym: "B lymphocyte dysfunction" EXACT [] synonym: "B lymphocyte functional anomalies" EXACT [] synonym: "B-cell dysfunction" EXACT [] is_a: MT:0003945 ! lymphocyte physiology [Term] id: MT:0002462 name: granulocyte physiology namespace: Trait.ontology def: "functional anomaly of neutrophils, eosinophils, or basophils " [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "granulocyte dysfunction" EXACT [] is_a: MT:0002442 ! leukocyte physiology [Term] id: MT:0002463 name: neutrophil physiology namespace: Trait.ontology def: "abnormal function of these granular leukocytes, which stain with neutral dyes" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] synonym: "neutrophil dysfunction" EXACT [] is_a: MT:0002462 ! granulocyte physiology [Term] id: MT:0002464 name: basophil physiology namespace: Trait.ontology def: "abnormal function of the leukocyte that contains granules that stain with basic dyes" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "basophil dysfunction" EXACT [] is_a: MT:0002462 ! granulocyte physiology [Term] id: MT:0002465 name: eosinophil physiology namespace: Trait.ontology def: "abnormal function of the leukocyte that stains with eosin and is involved in clearance of parasitic infections and in allergic reactions " [Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] synonym: "eosinophil dysfunction" EXACT [] is_a: MT:0002462 ! granulocyte physiology [Term] id: MT:0002467 name: neutrophil phagocytosis namespace: Trait.ontology def: "reduced ability of these leukocytes to internalize particulate matter" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] is_a: MT:0002463 ! neutrophil physiology is_a: MT:0002488 ! phagocytic cell physiology [Term] id: MT:0002468 name: complement physiology namespace: Trait.ontology def: "abnormal function of the set of plasma proteins that act together to attack extracellular pathogens" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] synonym: "complement dysfunction" EXACT [] is_a: MT:0001800 ! humoral immune response is_a: MT:0002419 ! innate immunity is_a: MT:0002723 ! immune serum protein physiology [Term] id: MT:0002469 name: C1 physiology namespace: Trait.ontology def: "abnormal function of the complement protein, C1" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "C1 dysfunction" EXACT [] is_a: MT:0001804 ! complement protein physiology [Term] id: MT:0002470 name: C2 physiology namespace: Trait.ontology def: "abnormal function of the complement protein, C2" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "C2 dysfunction" EXACT [] is_a: MT:0001804 ! complement protein physiology [Term] id: MT:0002471 name: complement cascade namespace: Trait.ontology def: "impaired ability of the complement proteins to act in concert and attack extracellular pathogens" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "complement cascade dysfunction" EXACT [] is_a: MT:0002468 ! complement physiology [Term] id: MT:0002472 name: complement alternative pathway function namespace: Trait.ontology def: "abnormal function of the plasma protein cascade triggered by direct contact with pathogen surfaces" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] is_a: MT:0002471 ! complement cascade [Term] id: MT:0002473 name: complement classical pathway function namespace: Trait.ontology def: "abnormal function of the plasma protein cascade triggered by antigen:antibody complexes" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] is_a: MT:0002471 ! complement cascade [Term] id: MT:0002474 name: C3 physiology namespace: Trait.ontology def: "abnormal function of the complement protein, C3" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "C3 dysfunction" EXACT [] is_a: MT:0001804 ! complement protein physiology [Term] id: MT:0002475 name: C4 physiology namespace: Trait.ontology def: "abnormal function of the complement protein, C4" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "C4 dysfunction" EXACT [] is_a: MT:0001804 ! complement protein physiology [Term] id: MT:0002476 name: C5 physiology namespace: Trait.ontology def: "abnormal function of the complement protein, C5" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "C5 dysfunction" EXACT [] is_a: MT:0001804 ! complement protein physiology [Term] id: MT:0002477 name: C6 physiology namespace: Trait.ontology def: "abnormal function of the complement protein, C6" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "C6 dysfunction" EXACT [] is_a: MT:0001804 ! complement protein physiology [Term] id: MT:0002478 name: C7 physiology namespace: Trait.ontology def: "abnormal function of the complement protein, C7" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "C7 dysfunction" EXACT [] is_a: MT:0001804 ! complement protein physiology [Term] id: MT:0002479 name: C8 physiology namespace: Trait.ontology def: "abnormal function of the complement protein, C8" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "C8 dysfunction" EXACT [] is_a: MT:0001804 ! complement protein physiology [Term] id: MT:0002480 name: C9 physiology namespace: Trait.ontology def: "abnormal function of the complement protein, C9" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "C9 dysfunction" EXACT [] is_a: MT:0001804 ! complement protein physiology [Term] id: MT:0002481 name: factor B physiology namespace: Trait.ontology def: "abnormal function of the complement protein, factor B" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "Bf abnormalities" EXACT [] synonym: "factor B dysfunction" EXACT [] is_a: MT:0001804 ! complement protein physiology [Term] id: MT:0002482 name: factor D physiology namespace: Trait.ontology def: "abnormal function of the complement protein, factor D" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "factor D dysfunction" EXACT [] is_a: MT:0001804 ! complement protein physiology [Term] id: MT:0002483 name: acute phase protein physiology namespace: Trait.ontology def: "functional anomaly in the series of proteins found in the blood shortly after infection and which participate in the early phases of host defense against infection" [Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] synonym: "acute phase protein dysfunction" EXACT [] is_a: MT:0002419 ! innate immunity is_a: MT:0002723 ! immune serum protein physiology [Term] id: MT:0002484 name: C-reactive protein physiology namespace: Trait.ontology def: "anomaly in the function of this plasma protein that normally circulates in increased amounts during inflammation or after tissue damage" [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "C-reactive protein dysfunction" EXACT [] is_a: MT:0002483 ! acute phase protein physiology [Term] id: MT:0002485 name: mannose-binding protein physiology namespace: Trait.ontology def: "an anomaly in the function of this acute phase protein that normally opsonizes pathogens bearing mannose on their surfaces and can activate the complement system" [Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] synonym: "mannose-binding protein dysfunction" EXACT [] is_a: MT:0002483 ! acute phase protein physiology [Term] id: MT:0002486 name: serum amyloid protein physiology namespace: Trait.ontology def: "functional anomaly in a serum protein believed to be a precursor to amyloid protein; it is present in very high levels during acute inflammatory episodes" [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "serum amyloid protein dysfunction" EXACT [] is_a: MT:0002483 ! acute phase protein physiology [Term] id: MT:0002487 name: fibrinogen physiology namespace: Trait.ontology def: "an anomaly in the function of this coaguable protein in the blood plasma" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "fibrinogen dysfunction" EXACT [] is_a: MT:0002483 ! acute phase protein physiology is_a: MT:0002551 ! blood coagulation [Term] id: MT:0002488 name: phagocytic cell physiology namespace: Trait.ontology def: "anomaly in the ability of these cells to ingest and internalize particulate matter" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "phagocytic cell dysfunction" EXACT [] is_a: MT:0002419 ! innate immunity [Term] id: MT:0002490 name: circulating immunoglobulin concentration namespace: Trait.ontology alt_id: MT:0001810 def: "deviation from the normal levels of glycoproteins present in the blood and other tissue, often functioning as antibodies" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] subset: slim_pig synonym: "abnormal immunoglobulin concentration" EXACT [] synonym: "abnormal serum immunoglobulin concentration" EXACT [] synonym: "Abnormal Serum Level of Immunoglobulin" EXACT [] is_a: MT:0001800 ! humoral immune response is_a: MT:0002459 ! B cell physiology is_a: MT:0002723 ! immune serum protein physiology [Term] id: MT:0002491 name: circulating IgD level namespace: Trait.ontology def: "less than normal immunoglobulin class D level" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] is_a: MT:0002490 ! circulating immunoglobulin concentration [Term] id: MT:0002492 name: circulating IgE level namespace: Trait.ontology def: "less than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] is_a: MT:0002490 ! circulating immunoglobulin concentration [Term] id: MT:0002498 name: acute inflammation namespace: Trait.ontology def: "aberrant early and often transient reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into extravascular tissues; initiated by injury, infection, or local immune response " [Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7, Pathology:ISBN 0-397-51047-0] comment: characterized by: accumulation of fluid and plasma components in the affected tissue, intravascular stimulation of platelets, presence of polymorphonuclear leukocytes, cwg synonym: "acute inflammation" EXACT [] is_a: MT:0001845 ! inflammatory response [Term] id: MT:0002499 name: chronic inflammation namespace: Trait.ontology def: "persistent inflammatory response, often caused by persistent infection or during an autoimmune response" [Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] comment: characterized by: lymphocytes, plasma cells, and macrophages, cwg is_a: MT:0001845 ! inflammatory response [Term] id: MT:0002500 name: granulomatous inflammation namespace: Trait.ontology def: "chronic inflammation resulting from the failure of the acute inflammatory response and persistence of the injurious agent; characterized by a central area of macrophages, often fused into giant cells, and surrounded by T cells " [Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7, Pathology:ISBN 0-397-51047-0] is_a: MT:0002499 ! chronic inflammation [Term] id: MT:0002501 name: inflammatory mediator physiology namespace: Trait.ontology def: "functional anomaly of any of the endogenous compounds that mediate the local accumulation of fluid, plasma proteins, and leukocytes at the site of injury, insult, or infection" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] subset: slim_pig synonym: "inflammatory mediators" EXACT [] is_a: MT:0001845 ! inflammatory response is_a: MT:0002723 ! immune serum protein physiology [Term] id: MT:0002502 name: vasoactive mediator physiology namespace: Trait.ontology def: "functional of any of the endogenous compounds that act on the vasculature" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] is_a: MT:0000249 ! blood vessel physiology [Term] id: MT:0002503 name: histamine physiology namespace: Trait.ontology def: "functional anomaly of this amine that is involved in local immune response, in regulating physiological function in the gut, and that acts as a neurotransmitter" [monikat:Monika Tomczuk_Mouse Genome Informatics Curator] comment: orig definition: functional anomaly of this potent vasoactive peptide stored in mast cells; it is normally released by antigen binding to IgE and results in dilation of local blood vessels and smooth muscle cell contraction; moved from immune system to homeostasis since this involves more than just immune system. is_a: MT:0001764 ! homeostasis [Term] id: MT:0002504 name: serotonin activity namespace: Trait.ontology def: "function of this biochemical messenger and regulator, found in the CNS, gastrointestinal tract, and produced by platelets; it normally mediates neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] synonym: "5-HT physiology" EXACT [] is_a: MT:0002206 ! CNS synaptic transmission is_a: MT:0002502 ! vasoactive mediator physiology [Term] id: MT:0002505 name: bradykinin activity namespace: Trait.ontology def: "function of this potent, short-lived vasoactive peptide that causes arteriolar dilation and increased capillary permeability" [ISBN:0-397-51047-0 "Rubin E & Farber, JL (ed) Pathology"] is_a: MT:0002502 ! vasoactive mediator physiology [Term] id: MT:0002506 name: anaphylotoxin activity namespace: Trait.ontology def: "function of any of the small fragments of complement proteins released by cleavage during complement activation, they are chemotactic and vasoactive" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] is_a: MT:0002502 ! vasoactive mediator physiology [Term] id: MT:0002507 name: C4a activity namespace: Trait.ontology def: "function of complement fragment C4a, which is normally involved in increasing vascular permeability and enhancing smooth muscle contraction" [ISBN:0-397-51047-0 "Rubin E & Farber, JL (ed) Pathology", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"] is_a: MT:0002506 ! anaphylotoxin activity [Term] id: MT:0002508 name: C5a activity namespace: Trait.ontology def: "function of this product of complement activation that is a potent chemotactic factor for neutrophils, monocytes, and basophils and enhances smooth muscle contraction and vascular permeability" [ISBN:0-397-51047-0 "Rubin E & Farber, JL (ed) Pathology", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"] is_a: MT:0002506 ! anaphylotoxin activity is_a: MT:0002523 ! chemotactic complement factor physiology [Term] id: MT:0002509 name: C3a activity namespace: Trait.ontology def: "function of complement fragment C3a, which is normally involved in increasing vascular permeability and enhancing smooth muscle contraction" [ISBN:0-397-51047-0 "Rubin E & Farber, JL (ed) Pathology", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"] is_a: MT:0002506 ! anaphylotoxin activity [Term] id: MT:0002510 name: leukotriene activity namespace: Trait.ontology def: "function of any of a family of mediators derived from arachadonic acid which normally stimulate smooth muscle contraction, increase vascular permeability, and may be chemoattractants for inflammatory cells" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] is_a: MT:0002502 ! vasoactive mediator physiology [Term] id: MT:0002511 name: LTC4 activity namespace: Trait.ontology def: "function of this member of a family of mediators derived from arachadonic acid that normally stimulates smooth muscle contraction, increases vascular permeability, and may be chemoattractant for inflammatory cells" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] synonym: "leukotriene C4 physiology" EXACT [] is_a: MT:0002510 ! leukotriene activity [Term] id: MT:0002512 name: LTD4 activity namespace: Trait.ontology def: "function of this member of a family of mediators derived from arachadonic acid that normally stimulates smooth muscle contraction, increases vascular permeability, and may be chemoattractant for inflammatory cells" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] synonym: "leukotriene D4 physiology" EXACT [] is_a: MT:0002510 ! leukotriene activity [Term] id: MT:0002513 name: LTE4 activity namespace: Trait.ontology def: "function of this member of a family of mediators derived from arachadonic acid that normally stimulates smooth muscle contraction, increases vascular permeability, and may be chemoattractant for inflammatory cells" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] synonym: "leukotriene E4 physiology" EXACT [] is_a: MT:0002510 ! leukotriene activity [Term] id: MT:0002514 name: prostaglandin activity namespace: Trait.ontology def: "function of any of a class of mediators with effects of vasodilation, vasoconstriction, and smooth muscle stimulation" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] is_a: MT:0002502 ! vasoactive mediator physiology [Term] id: MT:0002516 name: PGE2 activity namespace: Trait.ontology def: "function of this member of the prostaglandin family, which normally has vasodilatory effects, increasing vascular permeability" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] synonym: "prostaglandin E2 physiology" EXACT [] is_a: MT:0002514 ! prostaglandin activity [Term] id: MT:0002517 name: PGI2 activity namespace: Trait.ontology def: "function of this member of the prostaglandin family that normally has vasodilatory effects, increasing vascular permeability" [ISBN:0-397-51047-0 "Rubin E & Farber, JL (ed) Pathology"] synonym: "prostacyclin physiology" EXACT [] synonym: "prostaglandin I2 physiology" EXACT [] is_a: MT:0002514 ! prostaglandin activity [Term] id: MT:0002518 name: PGF2alpha activity namespace: Trait.ontology def: "function of this prostaglandin that normally has vasocontractile, oxytocic, luteolytic, and abortifacient activities" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] synonym: "prostaglandin F2alpha physiology" EXACT [] is_a: MT:0002514 ! prostaglandin activity [Term] id: MT:0002519 name: thromboxane activity namespace: Trait.ontology def: "function of any of the members of a family of mediators with vasoactive effects" [MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"] synonym: "TxB2 physiology" EXACT [] is_a: MT:0002502 ! vasoactive mediator physiology [Term] id: MT:0002520 name: TxA2 activity namespace: Trait.ontology def: "function of this potent vasoconstrictor that also mediates platelet aggregation" [ISBN:0-397-51047-0 "Rubin E & Farber, JL (ed) Pathology"] synonym: "thromboxane A2 physiology" EXACT [] is_a: MT:0002519 ! thromboxane activity [Term] id: MT:0002521 name: platelet activating factor activity namespace: Trait.ontology def: "function of this mediator generated by nearly all activated inflammatory cells, endothelial cells, and injured tissue cells; normally it is a potent vasodilator and enhances microvasculature permeability, in addition, it induces platelet aggregation and degranulation at sites of injury and enhances the release of serotonin" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] synonym: "PAF physiology" EXACT [] is_a: MT:0002502 ! vasoactive mediator physiology [Term] id: MT:0002522 name: chemotactic factor physiology namespace: Trait.ontology def: "functional anomaly of any of a class of pro-inflammatory proteins that attract and activate leukocytes" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Pathology:ISBN 0-397-51047-0] synonym: "chemotactic factors" EXACT [] is_a: MT:0002501 ! inflammatory mediator physiology [Term] id: MT:0002523 name: chemotactic complement factor physiology namespace: Trait.ontology def: "functional anomaly of any of a subset of complement fragments that are involved in recruitment of leukocytes to the site of injury " [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] synonym: "chemotactic complement factors" EXACT [] is_a: MT:0002522 ! chemotactic factor physiology [Term] id: MT:0002525 name: LTB4 physiology namespace: Trait.ontology def: "functional anomaly of this product of inflammatory cell activation that is a potent chemoattractant for macrophages and neutrophils" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Pathology:ISBN 0-397-51047-0] synonym: "abnormal leukotriene B4 physiology" EXACT [] is_a: MT:0005467 ! chemotactic leukotriene physiology [Term] id: MT:0002526 name: chemokine physiology namespace: Trait.ontology def: "functional anomaly of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] synonym: "chemokines" EXACT [] is_a: MT:0002522 ! chemotactic factor physiology [Term] id: MT:0002527 name: IL-8 physiology namespace: Trait.ontology def: "functional anomaly of this protein secreted by macrophages and is chemotactic for neutrophils and T cells" [Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] synonym: "abnormal interleukin-8 physiology" EXACT [] is_a: MT:0002529 ! interleukin physiology is_a: MT:0005050 ! chemotactic interleukin physiology [Term] id: MT:0002528 name: IL-1 physiology namespace: Trait.ontology def: "functional anomaly of this soluble factor produced by macrophages/monocytes that activates vascular endothelium and lymphocytes" [Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] synonym: "abnormal interleukin-1 physiology" EXACT [] is_a: MT:0002529 ! interleukin physiology [Term] id: MT:0002529 name: interleukin physiology namespace: Trait.ontology def: "functional anomaly of any of the cytokines produced by leukocytes" [Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] subset: slim_pig synonym: "abnormal lymphokines physiology" EXACT [] is_a: MT:0005049 ! cytokine physiology [Term] id: MT:0002530 name: TNF physiology namespace: Trait.ontology def: "functional anomaly of this cytokine produced by macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium " [Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] synonym: "abnormal cachectin physiology" EXACT [] synonym: "abnormal tumor necrosis factor alpha physiology" EXACT [] is_a: MT:0005049 ! cytokine physiology [Term] id: MT:0002531 name: type I hypersensitivity reaction namespace: Trait.ontology def: "a reaction manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology_2nd edition:ISBN 0-397-51047-0] comment: examples: hay fever, asthma, anaphylaxis synonym: "anaphylaxis" EXACT [] synonym: "immediate type hypersensitivity" EXACT [] is_a: MT:0002148 ! immune system: hypersensitivity [Term] id: MT:0002532 name: type II hypersensitivity reaction namespace: Trait.ontology def: "response caused by an Ag-Ab reaction; antibodies are directly or indirectly cytotoxic to antigens on cell surfaces or in connective tissues; most often involves IgG and IgM; complement activation is usually involved" [Pathology_2nd edition:ISBN 0-397-51047-0] comment: examples: autoimmune diseases: autoimmune hemolytic anemias, antibody-dependent cellular cytotoxicity (ADCC), Goodpasture disease, myasthenia gravis, Graves disease, pemphigous, pemphigoid synonym: "antibody-mediated cellular toxicity" EXACT [] synonym: "cytotoxic type hypersensitivity" EXACT [] is_a: MT:0002148 ! immune system: hypersensitivity [Term] id: MT:0002533 name: type III hypersensitivity reaction namespace: Trait.ontology def: "tissue injury mediated by immune complexes; generally involves immune complexes formed in the blood via Abs encountering circulating Ag; Ag-Ab complexes then deposit in tissues (especially blood vessels and glomeruli), induce complement activation, and result in tissue injury" [Pathology_2nd edition:ISBN 0-397-51047-0] comment: Examples: Autoimmune diseases: systemic lupus erythmatosus (SLE), rheumatoid arthritis, sjogren syndrome, scleroderma glomerulonephritis synonym: "immune complex mediated hypersensitivity" EXACT [] is_a: MT:0002148 ! immune system: hypersensitivity [Term] id: MT:0002534 name: type IV hypersensitivity reaction namespace: Trait.ontology def: "an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact" [Pathology_2nd edition:ISBN 0-397-51047-0] comment: Examples: granulomatous diseases: tuberculosis, sarcoidosis. contact dermatitis: elicited by poison ivy, detergents, clothing, etc. synonym: "cell-mediated hypersensitivity" EXACT [] synonym: "contact hypersensitivity" EXACT [] synonym: "delayed type hypersensitivity" EXACT [] is_a: MT:0002148 ! immune system: hypersensitivity [Term] id: MT:0002535 name: combined T cell/ B cell deficiency namespace: Trait.ontology def: "defective or absent host defense involving both B and T cells" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "combined T-cell/B-cell deficiency" EXACT [] is_a: MT:0001791 ! immunodeficiency [Term] id: MT:0002536 name: severe combined immunodeficiency disease namespace: Trait.ontology def: "rare congenital disorder characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels" [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "SCID" EXACT [] is_a: MT:0001800 ! humoral immune response is_a: MT:0002421 ! cell-mediated immunity is_a: MT:0002535 ! combined T cell/ B cell deficiency [Term] id: MT:0002539 name: B cell deficiency namespace: Trait.ontology def: "defective or absent host defense involving B cells" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] synonym: "B-cell deficiency" EXACT [] synonym: "deficiency of antibody immunity" EXACT [] is_a: MT:0001791 ! immunodeficiency [Term] id: MT:0002540 name: congenital X-linked infantile hypogammaglobulinemia namespace: Trait.ontology def: "an immunologic deficiency state characterized by very low level of generally all classes of gamma-immunoglobulins " [MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0001805 ! circulating IgG level [Term] id: MT:0002541 name: selective IgA deficiency namespace: Trait.ontology def: "an immunologic deficiency state characterized by very low levels of the immunoglobulin class A" [OMIM:Online Mendelian Inheritance in Man] is_a: MT:0002539 ! B cell deficiency [Term] id: MT:0002543 name: phalanx length namespace: Trait.ontology def: "abnormally short phalanges" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0005306 ! phalanx morphology [Term] id: MT:0002544 name: digit length namespace: Trait.ontology def: "abnormally short digits" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002110 ! digit morphology [Term] id: MT:0002546 name: synchronization of pupil reflex namespace: Trait.ontology is_a: MT:0002638 ! pupillary reflex [Term] id: MT:0002551 name: blood coagulation namespace: Trait.ontology alt_id: MT:0000210 alt_id: MT:0001582 def: "altered ability or inability of the blood to clot" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] comment: pslim term synonym: "abnormal clotting" EXACT [] synonym: "hematology: abnormal blood coagulation" EXACT [] xref: MGI:2173585 is_a: MT:0001764 ! homeostasis [Term] id: MT:0002557 name: social/conspecific interaction namespace: Trait.ontology alt_id: MT:0001351 subset: slim_cattle subset: slim_chkn synonym: "abnormal social behavior" EXACT [] synonym: "abnormal socialization" EXACT [] synonym: "neurological/behavioral: social/conspecific interaction anomalies" EXACT [] is_a: MT:0005386 ! behavior/neurological trait [Term] id: MT:0002558 name: circadian period namespace: Trait.ontology is_a: MT:0001502 ! circadian rhythm [Term] id: MT:0002559 name: circadian persistence namespace: Trait.ontology is_a: MT:0001502 ! circadian rhythm [Term] id: MT:0002561 name: circadian phase namespace: Trait.ontology is_a: MT:0001502 ! circadian rhythm [Term] id: MT:0002566 name: sexual interaction namespace: Trait.ontology alt_id: MT:0001369 alt_id: MT:0001370 alt_id: MT:0001374 def: "altered initiation, failure of initiation or incomplete mating behavior" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] synonym: "abnormal breeding" EXACT [] synonym: "abnormal breeding/mating" EXACT [] synonym: "abnormal mating" EXACT [] is_a: MT:0002557 ! social/conspecific interaction [Term] id: MT:0002568 name: response to addictive substances namespace: Trait.ontology synonym: "neurological/behavioral: addiction/drug abuse" EXACT [] is_a: MT:0005386 ! behavior/neurological trait [Term] id: MT:0002572 name: emotion/affect behavior namespace: Trait.ontology subset: slim_chkn subset: slim_pig is_a: MT:0005386 ! behavior/neurological trait [Term] id: MT:0002574 name: vertical activity level namespace: Trait.ontology is_a: MT:0001399 ! activity level [Term] id: MT:0002576 name: enamel morphology namespace: Trait.ontology def: "malformation of the hard outer coating of the exposed portion of the tooth" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, J:71126, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal enamel" EXACT [] is_a: MT:0003930 ! tooth hard tissue morphology [Term] id: MT:0002578 name: ability to fire action potentials namespace: Trait.ontology def: "anomaly resulting in reduced changes in membrane potentials occurring in nerve or other excitable tissue when excitation occurs" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, J:51377] is_a: MT:0005402 ! action potential [Term] id: MT:0002579 name: secondary lens fiber morphology namespace: Trait.ontology def: "deformation or misalignment of the elongated cells that form the crystalline lens" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, J:70385, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002840 ! lens fiber morphology [Term] id: MT:0002580 name: duodenal lesions namespace: Trait.ontology def: "any pathological change in the structure of the wall of the duodenum" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, J:70183] is_a: MT:0003271 ! duodenum morphology [Term] id: MT:0002581 name: ileum morphology namespace: Trait.ontology def: "malformation of the portion of the small intestine that extends from the jejunum to the colon" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, J:70183, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal ileum" EXACT [] is_a: MT:0000496 ! small intestine morphology [Term] id: MT:0002582 name: disorganized extraembryonic tissue namespace: Trait.ontology def: "a lack of the regular arrangement of the membranes involved with the embryo's protection and nutrition" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, J:40596] is_a: MT:0002086 ! extraembryonic tissue morphology [Term] id: MT:0002585 name: response/metabolism to xenobiotics namespace: Trait.ontology def: "altered ability or inability to metabolize or respond to foreign substances" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, J:55555] synonym: "abnormal metabolism of xenobiotics" EXACT [] is_a: MT:0002121 ! metabolism [Term] id: MT:0002586 name: platelet volume namespace: Trait.ontology def: "anomaly in the content of platelet cells over normal" [cml:Cathleen M. Lutz_Mouse Genome Informatics Curator] is_a: MT:0000228 ! thrombopoiesis [Term] id: MT:0002594 name: mean erythrocyte count namespace: Trait.ontology def: "less than average numbers of red blood cells" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "low mean RBC count" EXACT [] synonym: "low mean red blood cell count" EXACT [] is_a: MT:0001586 ! erythrocyte count [Term] id: MT:0002596 name: hematocrit namespace: Trait.ontology alt_id: MT:0000206 alt_id: MT:0001578 def: "greater or less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine_Medical Subject Headings] subset: slim_cattle subset: slim_chkn synonym: "hematocrit traits" EXACT [] synonym: "packed cell volume" EXACT [] is_a: MT:0002124 ! red blood cell [Term] id: MT:0002599 name: mean platelet volume namespace: Trait.ontology def: "increased content of platelet cells over normal" [cml:Cathleen M. Lutz_Mouse Genome Informatics Curator] synonym: "high mean platelet volume" EXACT [] is_a: MT:0002586 ! platelet volume [Term] id: MT:0002607 name: basophil count namespace: Trait.ontology def: "lower than average number of basophils as measured by the percent of the total number of leukocytes" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, MPD:Mouse Phenome Database] synonym: "decreased basophil number" EXACT [] synonym: "low basophil count" EXACT [] is_a: MT:0000334 ! granulocyte number is_a: MT:0002422 ! basophil morphology/development [Term] id: MT:0002619 name: lymphocyte morphology/development namespace: Trait.ontology alt_id: MT:0005063 def: "anomalous structure, differentiation, or number of the white blood cells formed in the body's lymphoid tissue" [MeSH:National Library of Medicine_Medical Subject Headings] subset: slim_pig synonym: "lymphocyte abnormalities" EXACT [] synonym: "lymphocyte structural abnormalities" EXACT [] is_a: MT:0002445 ! mononuclear leukocyte morphology/development [Term] id: MT:0002620 name: monocyte morphology/development namespace: Trait.ontology def: "anomalous structure, number, or development of the white blood cells that are precursors to macrophages" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] synonym: "monocyte abnormalities" EXACT [] is_a: MT:0001601 ! myelopoiesis is_a: MT:0002445 ! mononuclear leukocyte morphology/development [Term] id: MT:0002621 name: time of neural tube closure namespace: Trait.ontology def: "delayed fusion of the neuroepithelial layer in early development" [cml:Cathleen M. Lutz_Mouse Genome Informatics Curator, J:79790] synonym: "delayed spina bifida" EXACT [] is_a: MT:0003720 ! neural tube closure [Term] id: MT:0002622 name: cochlear hair cell morphology namespace: Trait.ontology def: "structure, form, organization, or number of the sensory epithelial cells of the cochlea; these cells are in synaptic contact with the auditory nerve" [pvb:Pierre Vanden Borre_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000042 ! organ of Corti is_a: MT:0000045 ! hair cell morphology is_a: MT:0003308 ! cochlear sensory epithelium morphology [Term] id: MT:0002623 name: vestibular hair cell morphology namespace: Trait.ontology def: "form, structure, organization, or number of the sensory epithelium of the maculae and cristae of the membranous labyrinth of the internal ear; afferent and efferent nerve fibers of the vestibular nerve end synaptically on them; from the apical end of each cell a bundle of stereocilia and a kinocilium extend into the statoconial membrane of the maculae and the cupula of the cristae" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000034 ! vestibule morphology is_a: MT:0000045 ! hair cell morphology [Term] id: MT:0002624 name: tricuspid valve integrity namespace: Trait.ontology def: "any measurable characteristic pertaining to the the structural completeness or structural soundness of the valve located between the right atrium and the right ventricle of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator", RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] is_a: MT:0002745 ! atrioventricular valve integrity relationship: part_of MT:0000036 ! tricuspid valve morphology [Term] id: MT:0002625 name: left ventricle cell size namespace: Trait.ontology def: "the physical dimensions, proportions, magnitude, or extent of the cells in the left lower chamber of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] synonym: "left ventricular cell size" RELATED [] is_a: MT:0001625 ! heart cell size relationship: part_of MT:0003921 ! left ventricle morphology [Term] id: MT:0002627 name: teratoma namespace: Trait.ontology def: "neoplasms composed of multiple tissue types; includes types not found in tissue in which lesion arises" [pvb:Pierre Vanden Borre_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002019 ! tumor incidence [Term] id: MT:0002628 name: fatty liver namespace: Trait.ontology def: "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre_Mouse Genome Informatics Curator] synonym: "hepatic steatosis" EXACT [] synonym: "liver adiposis" EXACT [] synonym: "liver steatosis" EXACT [] is_a: MT:0000598 ! liver morphology [Term] id: MT:0002629 name: activity elicited by ethanol administration namespace: Trait.ontology is_a: MT:0001399 ! activity level [Term] id: MT:0002630 name: endocochlear potential namespace: Trait.ontology def: "the electrical potential difference between the endolymphatic and perilymphatic compartments of the cochlea" [J:80917, pvb:Pierre Vanden Borre_Mouse Genome Informatics Curator] synonym: "abnormal endolymphatic potential" EXACT [] is_a: MT:0000319 ! endolymph physiology is_a: MT:0000365 ! hearing electrophysiology is_a: MT:0000483 ! sensorineural hearing function [Term] id: MT:0002631 name: epididymis morphology namespace: Trait.ontology def: "malformation of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [pvb:Pierre Vanden Borre_Mouse Genome Informatics Curator] synonym: "parorchis" EXACT [] is_a: MT:0001145 ! male reproductive anatomy [Term] id: MT:0002634 name: sensorimotor gating namespace: Trait.ontology def: "malfunction of the process by which inhibitory neural pathways filter multiple stimuli and allow attention to be focused on one stimulus; usually measured by pre-pulse inhibition (PPI)" [J:42758, pvb:Pierre Vanden Borre_Mouse Genome Informatics Curator] is_a: MT:0003633 ! nervous system physiology [Term] id: MT:0002636 name: time of vaginal opening namespace: Trait.ontology def: "the opening of the genital canal in a female occurring at a later than expected age" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "delayed vaginal opening time" EXACT [] is_a: MT:0001938 ! time of sexual maturation [Term] id: MT:0002637 name: uterus size namespace: Trait.ontology def: "reduced size of the female muscular organ of gestation" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] subset: slim_pig is_a: MT:0001120 ! uterus morphology [Term] id: MT:0002638 name: pupillary reflex namespace: Trait.ontology def: "change in pupil diameter as a reflex response to any stimulus" [cml:Cathleen M. Lutz_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001961 ! reflex is_a: MT:0005253 ! eye physiology [Term] id: MT:0002640 name: reticulocytosis namespace: Trait.ontology def: "an increase in the number of reticulocytes in the blood" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, J:78271] is_a: MT:0002124 ! red blood cell [Term] id: MT:0002641 name: anisopoikilocytosis namespace: Trait.ontology def: "presence in blood of RBCs of abnormal shapes and sizes" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, J:78271] is_a: MT:0002447 ! erythrocyte morphology [Term] id: MT:0002642 name: anisocytosis namespace: Trait.ontology alt_id: MT:0000246 alt_id: MT:0001609 def: "blood cells of variable size on smear" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, J:7209] synonym: "anisocytosis" EXACT [] is_a: MT:0002641 ! anisopoikilocytosis [Term] id: MT:0002643 name: poikilocytosis namespace: Trait.ontology def: "blood cells of variable shape on smear" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, J:7209] is_a: MT:0002641 ! anisopoikilocytosis [Term] id: MT:0002644 name: circulating triglyceride level namespace: Trait.ontology alt_id: MT:0005143 def: "lower than normal concentration of triacylglycerols in the blood" [pvb:Pierre Vanden Borre_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] subset: slim_chkn synonym: "low plasma triacylglycerol level" EXACT [] synonym: "low plasma triglyceride level" EXACT [] synonym: "low serum triacylglycerol level" EXACT [] synonym: "low serum triglyceride level" EXACT [] is_a: MT:0000187 ! triglyceride level is_a: MT:0003949 ! circulating lipid level [Term] id: MT:0002645 name: cholesterol absorption namespace: Trait.ontology def: "anomalous ability of the body to take in these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0005342 ! lipid absorption [Term] id: MT:0002648 name: delaminated enamel namespace: Trait.ontology def: "separation of the hard outer coating of the exposed portion of the tooth from the underlying hard tissue" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002576 ! enamel morphology [Term] id: MT:0002649 name: enamel rod pattern namespace: Trait.ontology def: "anomalous orientation of the structural unit of tooth enamel " [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002576 ! enamel morphology [Term] id: MT:0002650 name: ameloblast morphology namespace: Trait.ontology def: "malformation of the epithelial cells of the inner layer of the enamel organ of the developing tooth" [il:Ira Lu_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal ameloblast" EXACT [] is_a: MT:0000116 ! tooth development [Term] id: MT:0002651 name: sciatic nerve morphology namespace: Trait.ontology def: "malformation, absence or misprojection of the nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity" [MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0001077 ! spinal nerve morphology [Term] id: MT:0002653 name: ependyma morphology namespace: Trait.ontology def: "malformation or absence of the cellular membrane that lines the brain ventricles and the central canal of the spinal cord" [il:Ira Lu_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal ependyma" EXACT [] is_a: MT:0002200 ! brain ventricle/choroid plexus morphology is_a: MT:0003632 ! nervous system morphology [Term] id: MT:0002654 name: spongiform encephalopathy namespace: Trait.ontology def: "a neurodegenerative state characterized by the appearance of large vacuolated areas in the brain cells, resembling a sponge" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] synonym: "spongiform degeneration" EXACT [] is_a: MT:0002229 ! neural integrity [Term] id: MT:0002655 name: keratinocyte morphology namespace: Trait.ontology def: "structural or developmental anomaly of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001216 ! epidermal layer morphology [Term] id: MT:0002656 name: keratinocyte differentiation namespace: Trait.ontology def: "developmental anomaly of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002655 ! keratinocyte morphology [Term] id: MT:0002657 name: chondrodystrophy namespace: Trait.ontology def: "abnormal development of the cartilage primordia of long bones, resulting in abnormally short extremities but normal head and trunk" [il:Ira Lu_Mouse Genome Informatics Curator] synonym: "chondrodysplasia" EXACT [] is_a: MT:0000164 ! cartilage development is_a: MT:0002113 ! skeleton development [Term] id: MT:0002658 name: liver regeneration namespace: Trait.ontology def: "deviation from the normal ability of liver to regenerate healthy tissue following partial hepatectomy" [il:Ira Lu_Mouse Genome Informatics Curator] is_a: MT:0000598 ! liver morphology [Term] id: MT:0002660 name: caput morphology namespace: Trait.ontology def: "anomalous structure of the head of the epididymis" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002631 ! epididymis morphology [Term] id: MT:0002661 name: corpus morphology namespace: Trait.ontology def: "anomalous structure of the body of the epididymis" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002631 ! epididymis morphology [Term] id: MT:0002662 name: cauda morphology namespace: Trait.ontology def: "anomalous structure of the tail of the epididymis" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002631 ! epididymis morphology [Term] id: MT:0002663 name: blastocele formation namespace: Trait.ontology def: "developmental anomaly resulting in the absence of the cavity in the blastula of the developing embryo" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, J:19904, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal cavitation" EXACT [] synonym: "absent blastocoel cavity" EXACT [] synonym: "absent blastocoele" EXACT [] synonym: "failure to cavitate" EXACT [] synonym: "failure to form blastocyst cavity" EXACT [] is_a: MT:0002085 ! embryonic tissue morphology [Term] id: MT:0002664 name: circulating adrenocorticotropin level namespace: Trait.ontology def: "decreased concentration in the blood of the pituitary hormone that stimulates the secretion of adrenal cortical steroids and induces growth of the adrenal cortex" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] subset: slim_pig synonym: "circulating adrenocorticotropic hormone level" EXACT [] synonym: "decreased serum levels of ACTH" EXACT [] synonym: "decreased serum levels of adrenocorticotropin" EXACT [] is_a: MT:0003966 ! adrenocorticotropin level is_a: MT:0005116 ! circulating pituitary hormone level [Term] id: MT:0002668 name: circulating potassium level namespace: Trait.ontology def: "anomalous concentration in the blood of this alkaline metallic element, the most abundant intracellular ion; anomalies in the extracellular (circulating) concentration have important implications for the function of excitable tissues, such as nerve and muscle" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "abnormal potassium level" EXACT [] is_a: MT:0000179 ! blood chemistry is_a: MT:0001765 ! ion homeostasis [Term] id: MT:0002669 name: scrotum morphology namespace: Trait.ontology def: "malformation of the external sac of skin that encloses the testes" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] subset: slim_cattle subset: slim_pig is_a: MT:0001145 ! male reproductive anatomy [Term] id: MT:0002671 name: belted namespace: Trait.ontology def: "the appearance of a stripe of white fur around the circumference of the abdomen" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0002075 ! coat color [Term] id: MT:0002672 name: branchial arch artery integrity namespace: Trait.ontology alt_id: MT:0001617 alt_id: MT:0001618 def: "completion, soundness or configuration of the vessels formed within the five pairs of branchial arches in embryogenesis; in the adult, some of these vessels give rise to the great vessels" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "abnormal aortic arches" EXACT [] synonym: "abnormal branchial arch arteries" EXACT [] is_a: MT:0002884 ! branchial arches [Term] id: MT:0002673 name: sperm count namespace: Trait.ontology def: "increased or decreased numbers of spermatozoa" [pvb:Pierre Vanden Borre_Mouse Genome Informatics Curator] subset: slim_cattle subset: slim_chkn synonym: "abnormal sperm number" EXACT [] is_a: MT:0001929 ! gametogenesis [Term] id: MT:0002674 name: sperm motility namespace: Trait.ontology def: "anomalies in the mobility of the spermatozoa" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] subset: slim_cattle subset: slim_chkn is_a: MT:0001929 ! gametogenesis [Term] id: MT:0002675 name: asthenozoospermia namespace: Trait.ontology def: "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [pvb:Pierre Vanden Borre_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "asthenospermia" EXACT [] synonym: "impaired sperm motility" EXACT [] is_a: MT:0002674 ! sperm motility [Term] id: MT:0002679 name: corpora lutea morphology namespace: Trait.ontology def: "malformed or absent yellow endocrine body formed in the ovary after follicle rupture" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] subset: slim_pig synonym: "abnormal corpus luteum" EXACT [] is_a: MT:0003356 ! luteinization [Term] id: MT:0002680 name: number of corpora lutea namespace: Trait.ontology def: "fewer than normal numbers of yellow endocrine body formed in the ovary after follicle rupture in a given oestrous cycle" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] subset: slim_pig is_a: MT:0002679 ! corpora lutea morphology [Term] id: MT:0002682 name: number of mature ovarian follicles namespace: Trait.ontology def: "fewer than normal numbers of spheroid cell aggregations in the ovary containing the ovum" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001131 ! ovarian follicle morphology [Term] id: MT:0002683 name: onset of fertility namespace: Trait.ontology def: "age at which animals develop the ability to produce live offspring" [llw2:Linda Washburn_Mouse Genome Informatics Curator] subset: slim_cattle subset: slim_chkn subset: slim_pig synonym: "age at first breeding" NARROW [] synonym: "age at first egg" NARROW [] synonym: "age at puberty" EXACT [] synonym: "age at sexual maturity" EXACT [] is_a: MT:0001937 ! sexual maturation is_a: MT:0002161 ! fertility/fecundity [Term] id: MT:0002685 name: proliferation of spermatogonia namespace: Trait.ontology def: "reduction in the proliferation of the spermatogonial stem cells either due to reduced mitosis or increased apoptosis" [J:62271, pvb:Pierre Vanden Borre_Mouse Genome Informatics Curator] is_a: MT:0001156 ! spermatogenesis [Term] id: MT:0002686 name: globozoospermia namespace: Trait.ontology def: "malformation of the acrosome resulting in a round sperm head" [J:57312, pvb:Pierre Vanden Borre_Mouse Genome Informatics Curator] synonym: "acrosome malformation of spermatozoa" EXACT [] synonym: "round sperm heads" EXACT [] synonym: "round-headed spermatozoa" EXACT [] is_a: MT:0001156 ! spermatogenesis is_a: MT:0002208 ! germ cell morphology [Term] id: MT:0002687 name: oligozoospermia namespace: Trait.ontology alt_id: MT:0002684 def: "reduced concentration of spermatozoa " [J:57312, pvb:Pierre Vanden Borre_Mouse Genome Informatics Curator] synonym: "oligospermia" EXACT [] synonym: "reduced sperm count" EXACT [] synonym: "reduced sperm number" EXACT [] is_a: MT:0001156 ! spermatogenesis is_a: MT:0002209 ! germ cell number is_a: MT:0002673 ! sperm count [Term] id: MT:0002689 name: molar morphology namespace: Trait.ontology def: "structural defect of the most posterior teeth located on either side of the jaw, and characterized by a large crown and broad chewing surface" [il:Ira Lu_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal molars" EXACT [] is_a: MT:0002100 ! tooth morphology [Term] id: MT:0002693 name: pancreas physiology namespace: Trait.ontology def: "aberrant function of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal pancreas function" EXACT [] is_a: MT:0001663 ! digestive system physiology is_a: MT:0002164 ! gland physiology [Term] id: MT:0002694 name: pancreas secretion namespace: Trait.ontology def: "altered ability of the pancreas to release its products" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] is_a: MT:0002693 ! pancreas physiology [Term] id: MT:0002695 name: circulating glucagon level namespace: Trait.ontology def: "anomalous blood concentration of this peptide hormone secreted by the alpha cells of the pancreas; normally leads to a rise in plasma glucose" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal glucagon level" EXACT [] is_a: MT:0002078 ! glucose homeostasis [Term] id: MT:0002697 name: eye size namespace: Trait.ontology def: "anomalous bulk of the organ of vision" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "eye size abnormalities" EXACT [] is_a: MT:0002092 ! eye morphology [Term] id: MT:0002698 name: sclera morphology namespace: Trait.ontology def: "structural anomaly of the fibrous, outer envelope of the eyeball, covering it entirely excepting the segment covered anteriorly by the cornea " [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "sclera abnormalities" EXACT [] synonym: "sclerotic coat abnormalities" EXACT [] synonym: "sclerotica abnormalities" EXACT [] synonym: "tunica albuginea oculi abnormalities" EXACT [] synonym: "tunica sclerotica abnormalities" EXACT [] is_a: MT:0002092 ! eye morphology [Term] id: MT:0002699 name: vitreous body namespace: Trait.ontology def: "anomalies of the transparent, semigelatinous substance that fills the cavity behind the crystalline lens of the eye and in front of the retina" [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "vitreous abnormalities" EXACT [] synonym: "vitreous body abnormalities" EXACT [] is_a: MT:0005195 ! posterior eye segment morphology is_a: MT:0005299 ! eye posterior chamber [Term] id: MT:0002700 name: opacity of vitreous body namespace: Trait.ontology alt_id: MT:0001291 def: "milky or cloudy eyeball that is impervious to light" [J:30249] synonym: "opacity of eyeball" EXACT [] is_a: MT:0002699 ! vitreous body [Term] id: MT:0002703 name: renal tubule morphology namespace: Trait.ontology def: "anomalous structure or development of the loops of Henle and collecting ducts in the kidney" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] is_a: MT:0003881 ! nephron morphology [Term] id: MT:0002704 name: tubular nephritis namespace: Trait.ontology def: "inflammation of the renal tubules" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001859 ! kidney inflammation is_a: MT:0002703 ! renal tubule morphology [Term] id: MT:0002705 name: renal tubule size namespace: Trait.ontology def: "enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] is_a: MT:0002703 ! renal tubule morphology [Term] id: MT:0002706 name: kidney size namespace: Trait.ontology def: "anomalous physical bulk one or both of the organs responsible for urine secretion" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] is_a: MT:0002135 ! kidney morphology [Term] id: MT:0002707 name: kidney weight namespace: Trait.ontology def: "anomaly in the heft of the organs responsible for urine secretion" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] is_a: MT:0002706 ! kidney size [Term] id: MT:0002708 name: kidney stones namespace: Trait.ontology alt_id: MT:0002709 def: "calculi occurring in the kidney" [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "kidney calcium calculi" EXACT [] is_a: MT:0005360 ! urolithiasis [Term] id: MT:0002713 name: glycogen catabolism namespace: Trait.ontology def: "inability to breakdown glycogen; or reduced or increased rate of glycogen breakdown" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] synonym: "abnormal glycogenolysis" EXACT [] is_a: MT:0005438 ! glycogen homeostasis [Term] id: MT:0002716 name: preputial gland size namespace: Trait.ontology def: "reduced size of the sebaceous glands of the corona and neck of the glans penis" [il:Ira Lu_Mouse Genome Informatics Curator, J:82312, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002717 ! preputial gland morphology [Term] id: MT:0002717 name: preputial gland morphology namespace: Trait.ontology def: "anomalous structure of the sebaceous glands of the corona and neck of the glans penis" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal preputial glands" EXACT [] is_a: MT:0000653 ! sex gland morphology [Term] id: MT:0002718 name: inner cell mass morphology namespace: Trait.ontology def: "malformed or absent cells of the blastocyst that develop into the body of the embryo" [pvb:Pierre Vanden Borre_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal embryoblast" EXACT [] is_a: MT:0002085 ! embryonic tissue morphology [Term] id: MT:0002722 name: immune system organ morphology namespace: Trait.ontology alt_id: MT:0000686 def: "anomalous structure/organization or development of lymphoid organs" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] subset: slim_chkn synonym: "abnormal lymph organ" EXACT [] synonym: "immune system: organ abnormalities" EXACT [] is_a: MT:0000685 ! immune system morphology [Term] id: MT:0002723 name: immune serum protein physiology namespace: Trait.ontology def: "abnormal concentration or function of circulating immune proteins" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] subset: slim_pig synonym: "immune system: serum protein abnormalities" EXACT [] is_a: MT:0001790 ! immune system physiology [Term] id: MT:0002725 name: vein morphology namespace: Trait.ontology def: "any measurable or observable structural characterisitic of the blood vessels that carry blood towards the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] synonym: "venous morphology" EXACT [] xref: MP:0002725 is_a: MT:0001614 ! blood vessel morphology [Term] id: MT:0002726 name: pulmonary vein morphology namespace: Trait.ontology def: "any measurable or observable structural characterisitic of the blood vessels that return oxygenated blood from the lungs to the left atrium of the heart" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] synonym: "pulmonary venous morphology" EXACT [] is_a: MT:0002725 ! vein morphology [Term] id: MT:0002729 name: canal morphology namespace: Trait.ontology def: "any anomaly or malformation of the tubular ducts of the inner ear" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal canals" EXACT [] is_a: MT:0000026 ! inner ear morphology [Term] id: MT:0002731 name: megacolon namespace: Trait.ontology def: "extreme dilation of the colon" [J:40722, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "giant colon" EXACT [] is_a: MT:0000495 ! colon morphology [Term] id: MT:0002732 name: trichoepithelioma namespace: Trait.ontology def: "benign hair follicle tumors that lack mature hair follicles, derived from basal cells of the hair follicles enclosing small keratin cysts" [il:Ira Lu_Mouse Genome Informatics Curator] is_a: MT:0002019 ! tumor incidence [Term] id: MT:0002733 name: thermal nociception namespace: Trait.ontology alt_id: MT:0001972 is_a: MT:0001968 ! touch/ nociception [Term] id: MT:0002734 name: mechanical nociception namespace: Trait.ontology alt_id: MT:0002737 is_a: MT:0001968 ! touch/ nociception [Term] id: MT:0002735 name: chemical nociception namespace: Trait.ontology is_a: MT:0001968 ! touch/ nociception [Term] id: MT:0002739 name: olfactory bulb development namespace: Trait.ontology def: "abnormality in the progression of the formation of the olfactory bulb" [J:65380, pvb:Pierre Vanden Borre_Mouse Genome Informatics Curator] is_a: MT:0000819 ! olfactory bulb morphology is_a: MT:0000913 ! brain development [Term] id: MT:0002741 name: olfactory bulb size namespace: Trait.ontology def: "reduced size of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [J:79871] is_a: MT:0000819 ! olfactory bulb morphology [Term] id: MT:0002743 name: glomerulonephritis namespace: Trait.ontology def: "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [pvb:Pierre Vanden Borre_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "glomerular nephritis" EXACT [] is_a: MT:0000523 ! cortical glomerulopathies is_a: MT:0001859 ! kidney inflammation [Term] id: MT:0002745 name: atrioventricular valve integrity namespace: Trait.ontology def: "any measurable characteristic pertaining to the the structural completeness or structural soundness of the valves that gate the flow of blood from the atria into the ventricles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] comment: take out this layer synonym: "abnormal atrioventricular valves" EXACT [] relationship: part_of MT:0000025 ! atrioventricular valve morphology relationship: part_of MT:0000053 ! heart integrity [Term] id: MT:0002746 name: semilunar valve morphology namespace: Trait.ontology def: "any measurable or observable characteristic related to the shape, structure, color or pattern of the valves that gate the flow of blood from the ventricles into the aorta and pulmonary trunk" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] is_a: MT:0000285 ! heart valve morphology [Term] id: MT:0002747 name: aortic valve integrity namespace: Trait.ontology def: "any measurable characteristic pertaining to the the structural completeness or structural soundness of the valve between the left ventricle and the ascending aorta" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator", RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] is_a: MT:0006049 ! semilunar valve integrity relationship: part_of MT:0000040 ! aortic valve morphology [Term] id: MT:0002748 name: pulmonary valve integrity namespace: Trait.ontology def: "any measurable characteristic pertaining to the the structural completeness or structural soundness of the valve between the right ventricle and the pulmonary trunk" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator", RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] is_a: MT:0006049 ! semilunar valve integrity relationship: part_of MT:0000044 ! pulmonary valve morphology [Term] id: MT:0002750 name: exophthalmos namespace: Trait.ontology def: "protrusion of one or both eyeballs" [il:Ira Lu_Mouse Genome Informatics Curator, J:47965] synonym: "bulging eyes" EXACT [] synonym: "proptosis" EXACT [] synonym: "protruding eyes" EXACT [] is_a: MT:0006195 ! position of eyes in the eye socket [Term] id: MT:0002751 name: autonomic nervous system morphology namespace: Trait.ontology def: "any malformation or absence of neurons in the motor system for the viscera, the smooth muscles of the body or exocrine glands; includes the enteric, parasympathetic, and sympathetic nervous systems taken together" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] synonym: "autonomic nervous system abnormalities" EXACT [] is_a: MT:0003632 ! nervous system morphology [Term] id: MT:0002752 name: somatic nervous system morphology namespace: Trait.ontology def: "malformation or absence of any of the cranial and spinal nerves or their ganglia or the peripheral sensory receptors" [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "somatic nervous system abnormalities" EXACT [] is_a: MT:0003632 ! nervous system morphology [Term] id: MT:0002753 name: left ventricle size namespace: Trait.ontology def: "the physical dimensions, proportions, magnitude, or extent of the left lower chamber of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] synonym: "left ventricular size" RELATED [] relationship: part_of MT:0003921 ! left ventricle morphology relationship: part_of MT:0005406 ! heart size [Term] id: MT:0002754 name: right ventricle size namespace: Trait.ontology def: "the physical dimensions, proportions, magnitude, or extent of the right lower chamber of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] subset: slim_chkn synonym: "right ventricular size" RELATED [] relationship: part_of MT:0003920 ! right ventricle morphology relationship: part_of MT:0005406 ! heart size [Term] id: MT:0002756 name: pyramidal neuron number namespace: Trait.ontology def: "fewer than average number of projection neurons in the hippocampus" [cml:Cathleen M. Lutz_Mouse Genome Informatics Curator, J:82964] synonym: "decreased pyramidal cell number" EXACT [] synonym: "reduced number of pyramidal cells" EXACT [] synonym: "reduced pyramidal cell number" EXACT [] is_a: MT:0005442 ! pyramidal neuron morphology [Term] id: MT:0002758 name: tail length namespace: Trait.ontology def: "straight line distance from the tip of the tail to the point of attachment to the body" [J:82849, pvb:Pierre Vanden Borre_Mouse Genome Informatics Curator] is_a: MT:0003456 ! tail size [Term] id: MT:0002759 name: caudal vertebrae morphology namespace: Trait.ontology alt_id: MT:0000456 def: "malformed bony segments of the tail, usually 27-30 present" [J:82849, pvb:Pierre Vanden Borre_Mouse Genome Informatics Curator] synonym: "abnormal tail vertebrae morphology" EXACT [] is_a: MT:0000137 ! vertebrae morphology is_a: MT:0002111 ! tail morphology is_a: MT:0002115 ! skeleton extremities morphology [Term] id: MT:0002760 name: ectopic pyramidal neurons namespace: Trait.ontology def: "mispositioned, triangular shaped projection neurons in the hippocampus" [J:4978, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "ectopic pyramidal cells" EXACT [] synonym: "heterotopic pyramidal cells" EXACT [] is_a: MT:0005442 ! pyramidal neuron morphology [Term] id: MT:0002761 name: hippocampal mossy fiber morphology namespace: Trait.ontology def: "absence or misprojection of axons of neuronal cells in the dentate gyrus" [J:4978, MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal hippocampal mossy fibers" EXACT [] is_a: MT:0000807 ! hippocampus morphology [Term] id: MT:0002762 name: ectopic granule cells namespace: Trait.ontology def: "granule cell body resides in a place other than the external or internal granule layer of the cerebellum" [J:4978] synonym: "ectopic granule neuron" EXACT [] synonym: "heterotopic granule cells" EXACT [] is_a: MT:0004098 ! granule neuron morphology [Term] id: MT:0002763 name: ectopic Bergmann glia cells namespace: Trait.ontology def: "mispositioned astrocyte-type glia cell associated with Purkinje cells in the cerebellum" [J:4978, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "heterotopic Bergmann glia cells" EXACT [] is_a: MT:0000875 ! cerebellar Purkinje cell layer morphology is_a: MT:0002182 ! astrocyte morphology [Term] id: MT:0002766 name: situs inversus namespace: Trait.ontology def: "lateral transposition of the viscera of the thorax and abdomen, sometimes incomplete" [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "visceral inversion" EXACT [] is_a: MT:0002089 ! postnatal growth/weight/body size [Term] id: MT:0002767 name: situs ambiguus namespace: Trait.ontology def: "abnormal organ position" [J:62608] is_a: MT:0002089 ! postnatal growth/weight/body size [Term] id: MT:0002769 name: vas deferens morphology namespace: Trait.ontology def: "malformation of the secretory duct of the testicle that carries spermatozoa, running from the epididymis, of which it is the continuation, to the prostatic urethra where it terminates to form ejaculatory duct" [pvb:Pierre Vanden Borre_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001145 ! male reproductive anatomy [Term] id: MT:0002773 name: circulating luteinizing hormone level namespace: Trait.ontology def: "lower than normal levels in the bloodstream of LH, the hormone that regulates steroid production by the interstitial cells of the testis and the ovary" [J:35132, MeSH:National Library of Medicine_Medical Subject Headings, pvb:Pierre Vanden Borre_Mouse Genome Informatics Curator] subset: slim_cattle subset: slim_chkn subset: slim_pig synonym: "decreased serum levels of LH" EXACT [] synonym: "decreased serum levels of luteinizing hormone" EXACT [] synonym: "decreased serum levels of lutropin" EXACT [] is_a: MT:0003361 ! circulating gonadotropin level is_a: MT:0003969 ! luteinizing hormone level is_a: MT:0005116 ! circulating pituitary hormone level [Term] id: MT:0002778 name: meroanencephaly namespace: Trait.ontology def: "type of anencephaly in which the brain and cranium are present in rudimentary form" [il:Ira Lu_Mouse Genome Informatics Curator, J:33716, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001890 ! anencephaly [Term] id: MT:0002779 name: sex gland secretion namespace: Trait.ontology def: "malfunction of the production and/or release of hormones from a cell or a gland of the reproductive system " [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0005647 ! sex gland physiology [Term] id: MT:0002782 name: testicular secretion namespace: Trait.ontology def: "malfunction of the production and/or release of hormones from testicular tissue" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0000051 ! testes physiology is_a: MT:0002779 ! sex gland secretion [Term] id: MT:0002783 name: ovarian secretion namespace: Trait.ontology def: "malfunction of the production and/or release of hormones from ovarian tissue" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0002779 ! sex gland secretion is_a: MT:0003507 ! ovary physiology [Term] id: MT:0002784 name: Sertoli cell morphology namespace: Trait.ontology def: "malformation of the cells of the seminiferous tubules that create the blood-testes barrier and enable spermatogenesis" [J:65900, pvb:Pierre Vanden Borre_Mouse Genome Informatics Curator] synonym: "abnormal Sertoli cells" EXACT [] is_a: MT:0002216 ! seminiferous tubule morphology [Term] id: MT:0002785 name: Leydig cell number namespace: Trait.ontology def: "lack of the interstitial cells of the seminiferous tubules that secrete testosterone" [J:65900, pvb:Pierre Vanden Borre_Mouse Genome Informatics Curator] synonym: "absence of Leydig cells" EXACT [] is_a: MT:0001940 ! testicular cell number is_a: MT:0002786 ! Leydig cell morphology [Term] id: MT:0002786 name: Leydig cell morphology namespace: Trait.ontology def: "malformation or absence of the interstitial cells of the seminiferous tubules that secrete testosterone" [pvb:Pierre Vanden Borre_Mouse Genome Informatics Curator] synonym: "abnormal Leydig cells" EXACT [] is_a: MT:0002216 ! seminiferous tubule morphology [Term] id: MT:0002787 name: pseudohermaphroditism namespace: Trait.ontology def: "unambiguous gonadal sex (i.e. possesses either testes or ovaries, consistent with chromosomal sex) but has ambiguous secondary sexual characteristics" [llw2:Linda Washburn_Mouse Genome Informatics Curator, pvb:Pierre Vanden Borre_Mouse Genome Informatics Curator] synonym: "false hermaphroditism" EXACT [] is_a: MT:0002212 ! secondary sex determination [Term] id: MT:0002788 name: female pseudohermaphroditism namespace: Trait.ontology def: "pseudohermaphroditism in which the gonads are female (ovaries) and the karyotype is XX but the secondary sex characteristics are male-like or ambiguous" [llw2:Linda Washburn_Mouse Genome Informatics Curator, pvb:Pierre Vanden Borre_Mouse Genome Informatics Curator] is_a: MT:0002787 ! pseudohermaphroditism [Term] id: MT:0002789 name: male pseudohermaphroditism namespace: Trait.ontology def: "pseudohermaphroditism in which the gonads are male (testes) and the karyotype is XY but the secondary sex characteristics are female-like or ambiguous" [llw2:Linda Washburn_Mouse Genome Informatics Curator, pvb:Pierre Vanden Borre_Mouse Genome Informatics Curator] is_a: MT:0002787 ! pseudohermaphroditism [Term] id: MT:0002790 name: circulating follicle stimulating hormone level namespace: Trait.ontology def: "less than expected blood concentration of the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] subset: slim_cattle subset: slim_chkn subset: slim_pig synonym: "decreased serum levels of follicle stimulating hormone" EXACT [] synonym: "decreased serum levels of follitropin" EXACT [] synonym: "decreased serum levels of FSH" EXACT [] synonym: "decreased serum levels of gametokinetic hormone" EXACT [] is_a: MT:0003361 ! circulating gonadotropin level is_a: MT:0003967 ! follicle stimulating hormone level is_a: MT:0005116 ! circulating pituitary hormone level [Term] id: MT:0002791 name: steatorrhea namespace: Trait.ontology def: "passage of large amounts of fat in the feces due to the inability to digest and absorb it" [J:75167] is_a: MT:0001666 ! nutrient absorption is_a: MT:0003868 ! feces composition [Term] id: MT:0002792 name: retina blood vessel morphology namespace: Trait.ontology alt_id: MT:0006189 def: "any measurable or observable characteristic related to the shape, structure, color or pattern of the blood vessels supplying the retina" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] synonym: "morphology of the retinal vasculature" RELATED [] synonym: "retinal vascular morphology" RELATED [] xref: MP:0002792 is_a: MT:0001325 ! retina morphology is_a: MT:0001614 ! blood vessel morphology [Term] id: MT:0002794 name: lenticonus namespace: Trait.ontology def: "a conical bulging of the lens capsule and the underlying cortex of the eye" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001286 ! eye development is_a: MT:0001303 ! lens morphology [Term] id: MT:0002796 name: skin barrier function namespace: Trait.ontology def: "impaired ability of the skin to regulate water loss; frequently leads to dehydration" [J:56641] is_a: MT:0001784 ! fluid regulation is_a: MT:0005501 ! skin physiology [Term] id: MT:0002800 name: short-term recognition memory namespace: Trait.ontology is_a: MT:0001458 ! object recognition memory is_a: MT:0001468 ! temporal memory [Term] id: MT:0002801 name: long-term recognition memory namespace: Trait.ontology is_a: MT:0001458 ! object recognition memory is_a: MT:0001468 ! temporal memory [Term] id: MT:0002802 name: discrimination learning namespace: Trait.ontology is_a: MT:0001449 ! learning/ memory [Term] id: MT:0002803 name: operant conditional behavior namespace: Trait.ontology is_a: MT:0002062 ! conditioning behavior [Term] id: MT:0002804 name: motor learning namespace: Trait.ontology is_a: MT:0001449 ! learning/ memory [Term] id: MT:0002806 name: conditioned emotional response namespace: Trait.ontology is_a: MT:0002062 ! conditioning behavior [Term] id: MT:0002807 name: eye blink conditioning behavior namespace: Trait.ontology is_a: MT:0002062 ! conditioning behavior [Term] id: MT:0002808 name: barbering namespace: Trait.ontology is_a: MT:0001440 ! grooming behavior [Term] id: MT:0002809 name: spinal cord size namespace: Trait.ontology def: "larger appearance of the spinal cord" [J:83935] is_a: MT:0000955 ! spinal cord morphology [Term] id: MT:0002810 name: microcytic anemia namespace: Trait.ontology def: "anemia in which the circulating erythrocyte corpuscular volume is smaller than normal" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001577 ! anemia [Term] id: MT:0002811 name: macrocytic anemia namespace: Trait.ontology def: "anemia in which the circulating erythrocyte corpuscular volume is larger than normal" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001577 ! anemia [Term] id: MT:0002812 name: spherocytosis namespace: Trait.ontology def: "the presence of sphere-shaped erythrocytes in the circulating blood" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002447 ! erythrocyte morphology [Term] id: MT:0002813 name: microcytosis namespace: Trait.ontology def: "the presence of unusually small erythrocytes in the circulating blood" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "microcythemia" EXACT [] is_a: MT:0002447 ! erythrocyte morphology [Term] id: MT:0002814 name: hyperchromasia namespace: Trait.ontology def: "increased capacity of a cell to stain with dye; usually refers to staining of cell nuclei with hematoxylin" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "hyperchromatism" EXACT [] is_a: MT:0002447 ! erythrocyte morphology [Term] id: MT:0002815 name: adenoma namespace: Trait.ontology def: "a benign epithelial neoplasm with a glandular organization; usually does not invade or infiltrate surrounding tissue" [MeSH:National Library of Medicine_Medical Subject Headings, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002019 ! tumor incidence [Term] id: MT:0002816 name: colitis namespace: Trait.ontology def: "local accumulation of fluid, plasma proteins, and leukocytes in the colon region of the large intestine" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0003304 ! large intestinal inflammation [Term] id: MT:0002817 name: tooth mineralization namespace: Trait.ontology def: "abnormalities in the process by which calcium salts are deposited into the dental enamel, dentin and cementum " [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "tooth mineralization defects" EXACT [] is_a: MT:0000116 ! tooth development is_a: MT:0003930 ! tooth hard tissue morphology [Term] id: MT:0002818 name: dentin morphology namespace: Trait.ontology def: "defects in the hard portion of the tooth surrounding the pulp, covered by enamel on the crown and cementum on the root" [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal dentin" EXACT [] synonym: "dentin abnormalities" EXACT [] synonym: "dentine abnormalities" EXACT [] is_a: MT:0003930 ! tooth hard tissue morphology [Term] id: MT:0002819 name: pulp cavity morphology namespace: Trait.ontology def: "defects in the central hollow space of a tooth" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal pulp cavity" EXACT [] synonym: "pulp cavity abnormalities" EXACT [] is_a: MT:0002100 ! tooth morphology [Term] id: MT:0002820 name: premaxilla morphology namespace: Trait.ontology def: "malformation or absence of the anterior and inner portion of the maxilla" [J:76662, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal incisive bone" EXACT [] synonym: "abnormal incisor bone" EXACT [] synonym: "abnormal intermaxillary bone" EXACT [] synonym: "abnormal premaxilla" EXACT [] is_a: MT:0000455 ! maxilla morphology [Term] id: MT:0002823 name: rib development namespace: Trait.ontology def: "anomalous formation of the bones forming the bony wall of the chest" [J:84754, pvb:Pierre Vanden Borre_Mouse Genome Informatics Curator] is_a: MT:0000150 ! rib morphology is_a: MT:0002113 ! skeleton development [Term] id: MT:0002824 name: chorioallantoic fusion namespace: Trait.ontology def: "abnormal process of or failure of the formation of the membrane that forms the fetal portion of the placenta; derived from the fusion of the chorion and the allantois" [hdene:Howard Dene_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001712 ! placental development is_a: MT:0001726 ! allantois morphology is_a: MT:0002836 ! chorion morphology [Term] id: MT:0002825 name: notochord morphology namespace: Trait.ontology def: "malformation or absence of the axial fibrocellular cord in embryos around which develops the vertebral primordia" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002085 ! embryonic tissue morphology [Term] id: MT:0002827 name: renal corpuscle morphology namespace: Trait.ontology def: "anomalous structure or development of either Bowman's capsules and/or the glomeruli contained therein" [pvb:Pierre Vanden Borre_Mouse Genome Informatics Curator] is_a: MT:0000521 ! kidney cortex is_a: MT:0003881 ! nephron morphology [Term] id: MT:0002828 name: glomerular capsule morphology namespace: Trait.ontology def: "anomalous structure or development of the expanded beginning of a nephron that contains the glomerulus" [pvb:Pierre Vanden Borre_Mouse Genome Informatics Curator] synonym: "abnormal Bowman's capsule" EXACT [] synonym: "abnormal capsula glomeruli" EXACT [] synonym: "abnormal malphighian capsule" EXACT [] is_a: MT:0002827 ! renal corpuscle morphology [Term] id: MT:0002829 name: juxtaglomerular apparatus morphology namespace: Trait.ontology def: "anomalous structure or development of the complex of modified smooth muscle cells consisting of juxtaglomerular cells, extraglomerular mesangium lacis cells, the macula densa of the distal convoluted tubule, and granular epithelial peripolar cells; these cells are found in the walls of afferent and efferent glomerular arterioles" [MeSH:National Library of Medicine_Medical Subject Headings, pvb:Pierre Vanden Borre_Mouse Genome Informatics Curator] is_a: MT:0005325 ! glomerulus morphology [Term] id: MT:0002830 name: gallstones namespace: Trait.ontology def: "caliculi in the gallbladder or a bile duct; chemical composition of cholesterol, calcium carbonate or calcium bilirubinate" [il:Ira Lu_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "biliary caliculi" EXACT [] synonym: "cholelithiasis" EXACT [] synonym: "gall stone" EXACT [] is_a: MT:0005085 ! gall bladder physiology [Term] id: MT:0002831 name: Peyer's patch size namespace: Trait.ontology def: "area of lymphoid tissue of the mucosa of the small intestine" [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "absence of Peyer's patches" EXACT [] is_a: MT:0000696 ! Peyer's patch morphology [Term] id: MT:0002832 name: coarse hair namespace: Trait.ontology def: "hair shafts that are twisted or coiled and are of uneven thickness produce an overall rugged or uneven appearance and roughness to the touch" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, J:56826, llw2:Linda Washburn_Mouse Genome Informatics Curator] is_a: MT:0002074 ! hair texture [Term] id: MT:0002835 name: cranial suture morphology namespace: Trait.ontology def: "defects of the fibrous joint in the bones of the head" [J:62161, MeSH:National Library of Medicine_Medical Subject Headings, pvb:Pierre Vanden Borre_Mouse Genome Informatics Curator] synonym: "abnormal cranial sutures" EXACT [] is_a: MT:0000438 ! skull morphology [Term] id: MT:0002836 name: chorion morphology namespace: Trait.ontology def: "malformations of the outermost extraembryonic membrane" [MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0002086 ! extraembryonic tissue morphology [Term] id: MT:0002840 name: lens fiber morphology namespace: Trait.ontology def: "structural anomaly of the elongated cells of the crystalline lens of the eye" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0005545 ! lens development [Term] id: MT:0002845 name: aorta weight namespace: Trait.ontology def: "mass of the main trunk of the systemic arteries times gravity" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] synonym: "aortic weight" RELATED [] relationship: part_of MT:0007090 ! aorta size [Term] id: MT:0002846 name: aorta volume namespace: Trait.ontology def: "physical bulk of or total amount of space encompassed by the main trunk of the systemic arteries" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] synonym: "aorta mass" RELATED [] synonym: "aortic volume" RELATED [] relationship: part_of MT:0007090 ! aorta size [Term] id: MT:0002847 name: glomerular filtration rate namespace: Trait.ontology def: "deviation from the normal volume of water filtered out of the plasma through glomerular capillary walls into the Bowman's capsule per unit time" [MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0003606 ! kidney function [Term] id: MT:0002849 name: saccharin consumption namespace: Trait.ontology is_a: MT:0001432 ! food preference [Term] id: MT:0002851 name: circulating sulfate level namespace: Trait.ontology def: "altered concentration of sulfate in the blood" [pvb:Pierre Vanden Borre_Mouse Genome Informatics Curator] synonym: "abnormal sulfate level" EXACT [] is_a: MT:0000179 ! blood chemistry [Term] id: MT:0002855 name: cochlear ganglion morphology namespace: Trait.ontology def: "malformation, malfunction or absence of the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain and resides on the cochlear part of the vestibulocochlear nerve (eighth cranial nerve)" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal auditory ganglion" EXACT [] synonym: "abnormal Corti ganglion" EXACT [] synonym: "abnormal spiral ganglion of vestibulocochlear (VIII) nerve" EXACT [] synonym: "cranial ganglion VIII" EXACT [] is_a: MT:0001081 ! cranial ganglia morphology [Term] id: MT:0002856 name: vestibular ganglion morphology namespace: Trait.ontology def: "malformation of the group of neurons associated with the vestibular part of the eighth cranial nerve that are involved in equilibration" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal Scarpa ganglion" EXACT [] synonym: "abnormal spiral ganglion" EXACT [] synonym: "abnormal vestibular ganglion of the vestibulocochlear (VIII) nerve" EXACT [] synonym: "cranial ganglion VIII" EXACT [] is_a: MT:0001081 ! cranial ganglia morphology [Term] id: MT:0002857 name: cochlear ganglion integrity namespace: Trait.ontology def: "loss of neural cell bodies in the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "degeneration of cochlear ganglion" EXACT [] synonym: "degeneration of spiral ganglion" EXACT [] is_a: MT:0002855 ! cochlear ganglion morphology [Term] id: MT:0002858 name: posterior semicircular canal namespace: Trait.ontology def: "form or structure of the posterior segment of the long bony tube of the labyrinth that is involved in the sense of balance" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002428 ! semicircular canal [Term] id: MT:0002860 name: dilated pupils namespace: Trait.ontology def: "pupils that remain widely opened regardless of light conditions" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0001317 ! pupil morphology [Term] id: MT:0002861 name: tail bud morphology namespace: Trait.ontology def: "anomalous formation of the primordial region of the embryo that arises to form the tail of the adult; appears approximately ten days following conception as a short stump, and then initiates elongation and thinning in normal development" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0006281 ! tail development [Term] id: MT:0002862 name: righting response namespace: Trait.ontology is_a: MT:0001516 ! motor coordination/ balance [Term] id: MT:0002864 name: ocular fundus morphology namespace: Trait.ontology def: "malformation of the posterior concave interior of the eye, consisting of the retina, the choroid, the posterior segment of the sclera, the optic disk, and blood vessels, visible by an ophthalmoscope" [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal fundus oculus" EXACT [] is_a: MT:0005195 ! posterior eye segment morphology [Term] id: MT:0002866 name: glutamic acid decarboxylase level namespace: Trait.ontology def: "aberrant concentration of this enzyme, which catalyzes the conversion of glutamate to gamma-aminobutyric acid (GABA) and carbon dioxide; determines GABA levels in nervous tissues" [MeSH:National Library of Medicine_Medical Subject Headings, RGD:Rat Genome Database submission] is_a: MT:0005319 ! enzyme/ coenzyme level [Term] id: MT:0002870 name: insulin autoantibody level namespace: Trait.ontology def: "reduced level of antibodies to insulin present in the sera" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0003726 ! autoantibody level [Term] id: MT:0002871 name: urine albumin level namespace: Trait.ontology def: "presence of excess albumin in the urine" [RGD:Rat Genome Database submission, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0005160 ! urine protein level [Term] id: MT:0002872 name: polycythemia namespace: Trait.ontology def: "an excess of circulating red blood cells" [MeSH:National Library of Medicine_Medical Subject Headings, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001586 ! erythrocyte count [Term] id: MT:0002876 name: thyroid physiology namespace: Trait.ontology def: "anomalous function of this endocrine gland that normally produces hormones that regulate the metabolic rate of the body " [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal thyroid function" EXACT [] is_a: MT:0002164 ! gland physiology [Term] id: MT:0002877 name: melanocyte morphology namespace: Trait.ontology def: "malformation of the cells that produce pigment " [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001186 ! pigmentation trait [Term] id: MT:0002878 name: corticospinal tract morphology namespace: Trait.ontology def: "anomaly in the structure of the fibers that arise from the cells within the cerebral cortex layer V, pass through the medullary pyramid, and descend into the gray matter of the spinal cord" [MeSH:National Library of Medicine_Medical Subject Headings, pvb:Pierre Vanden Borre_Mouse Genome Informatics Curator] synonym: "abnormal corticobulbar tract" EXACT [] synonym: "abnormal pyramidal tract" EXACT [] is_a: MT:0000778 ! tract morphology [Term] id: MT:0002879 name: cellular sensitivity to X-ray irradiation namespace: Trait.ontology def: "increased incidence of cell death following exposure to high levels of X-ray irradiation" [RGD:Rat Genome Database submission] is_a: MT:0004228 ! cellular sensitivity to ionizing radiation [Term] id: MT:0002880 name: opisthotonus namespace: Trait.ontology def: "a form of tetanic spasm in which the head, neck and spine are bent backward and the body is bowed forward" [MeSH:National Library of Medicine_Medical Subject Headings] comment: Stedman's says that both the -us and the -os spellings are correct and synonymous synonym: "opisthotonos" EXACT [] is_a: MT:0000743 ! muscle spasms [Term] id: MT:0002882 name: neuron namespace: Trait.ontology def: "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0003632 ! nervous system morphology [Term] id: MT:0002883 name: chromatolysis namespace: Trait.ontology def: "the dissolution of the granules of chromophil substance in a nerve cell body that may occur in injured cells or axons" [dlb:Donna Burkart_Mouse Genome Informatics Curator] is_a: MT:0002882 ! neuron [Term] id: MT:0002884 name: branchial arches namespace: Trait.ontology def: "malformation or anomaly in the transient structures of the embryo that develop into regions of the head, neck and ears" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] synonym: "abnormal pharyngeal arches" EXACT [] is_a: MT:0002085 ! embryonic tissue morphology is_a: MT:0003935 ! craniofacial development [Term] id: MT:0002885 name: AMPA-mediated synaptic currents namespace: Trait.ontology def: "change in the measured amplitude or duration of response to stimulation of AMPA receptors" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0002886 ! glutamate receptor currents [Term] id: MT:0002886 name: glutamate receptor currents namespace: Trait.ontology def: "change in the measured amplitude or duration of response to stimulation of glutamanergic receptors" [Principles of Neural Science_3rd edition:ISBN 0-8385-8034-3] is_a: MT:0002206 ! CNS synaptic transmission [Term] id: MT:0002888 name: NMDA-mediated synaptic currents namespace: Trait.ontology def: "change in the measured amplitude or duration of response to stimulation of NMDA receptors" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0002886 ! glutamate receptor currents [Term] id: MT:0002889 name: hepatoma susceptibility namespace: Trait.ontology def: "likelihood of developing a malignant tumor composed of neoplastic liver cells" [RGD:Rat Genome Database submission] is_a: MT:0002028 ! hepatoma [Term] id: MT:0002890 name: hepatoma resistance namespace: Trait.ontology def: "decreased likelihood of developing a malignant tumor composed of neoplastic liver cells" [RGD:Rat Genome Database submission] is_a: MT:0002028 ! hepatoma [Term] id: MT:0002891 name: insulin sensitivity namespace: Trait.ontology def: "ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission] is_a: MT:0002078 ! glucose homeostasis [Term] id: MT:0002893 name: urine keto acid level namespace: Trait.ontology def: "excretion of urine having an elevated concentration of keto acids" [pvb:Pierre Vanden Borre_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001757 ! urine chemistry [Term] id: MT:0002894 name: otolith morphology namespace: Trait.ontology def: "structure, form, or number of the crystalline particles composed of calcium carbonate and a protein which adhere to the gelatinous membrane of the maculae of the utricle and saccule (otolithic membrane)" [llw2:Linda Washburn_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "ear crystal morphology" EXACT [] synonym: "otoconia morphology" EXACT [] synonym: "statoconia morphology" EXACT [] synonym: "statolith morphology" EXACT [] is_a: MT:0002895 ! otolithic membrane morphology [Term] id: MT:0002895 name: otolithic membrane morphology namespace: Trait.ontology def: "form or structure of the gelatinous membrane which is supported by the stereocilia of the hair cells of the maculae of the saccule and utriculus of the inner ear; adhering to its surface are numerous calciferous crystalline particles called otoliths (statoconia)" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] synonym: "membrana statoconiorum morphology" EXACT [] synonym: "statoconial membrane morphology" EXACT [] is_a: MT:0004425 ! otolith organ morphology [Term] id: MT:0002896 name: bone mineralization namespace: Trait.ontology def: "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] subset: slim_chkn is_a: MT:0001533 ! skeleton physiology [Term] id: MT:0002897 name: blotchy skin namespace: Trait.ontology def: "regions of spotted discoloration appearing in the dermal tissue" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0001191 ! skin condition [Term] id: MT:0002899 name: stamina namespace: Trait.ontology synonym: "fatigability" EXACT [] synonym: "fatigable" EXACT [] is_a: MT:0002071 ! other behavior [Term] id: MT:0002900 name: urine phosphate level namespace: Trait.ontology def: "any change in the level of excretion of phosphate in the urine" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0001757 ! urine chemistry [Term] id: MT:0002903 name: circulating parathyroid hormone level namespace: Trait.ontology def: "aberration in the blood concentration of this regulator of calcium and phosphorous concentration" [pvb:Pierre Vanden Borre_Mouse Genome Informatics Curator] synonym: "abnormal circulating level of parathyroid hormone" EXACT [] synonym: "abnormal circulating PTH level" EXACT [] is_a: MT:0005418 ! circulating hormone level [Term] id: MT:0002907 name: parturition namespace: Trait.ontology def: "defect in the process of labor and delivery in female animals" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] subset: slim_cattle subset: slim_pig is_a: MT:0003699 ! female reproductive system physiology [Term] id: MT:0002908 name: time to wound healing namespace: Trait.ontology def: "longer time requirement for the ability to self-repair and close wounds than normal" [J:63037] is_a: MT:0005023 ! wound healing [Term] id: MT:0002909 name: adrenal gland physiology namespace: Trait.ontology def: "altered ability of the surparenal gland to produce and secrete hormones " [hdene:Howard Dene_Mouse Genome Informatics Curator] synonym: "abnormal adrenal gland function" EXACT [] is_a: MT:0002164 ! gland physiology [Term] id: MT:0002910 name: excitatory postsynaptic currents namespace: Trait.ontology def: "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science_3rd edition:ISBN 0-8385-8034-3] synonym: "abnormal EPSCs" EXACT [] is_a: MT:0002206 ! CNS synaptic transmission [Term] id: MT:0002911 name: inhibitory postsynaptic potential namespace: Trait.ontology def: "defect in the membrane potential detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [Principles of Neural Science_3rd edition:ISBN 0-8385-8034-3] synonym: "abnormal IPSP" EXACT [] is_a: MT:0002206 ! CNS synaptic transmission [Term] id: MT:0002912 name: excitatory postsynaptic potential namespace: Trait.ontology def: "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science_3rd edition:ISBN 0-8385-8034-3] synonym: "abnormal EPSP" EXACT [] is_a: MT:0002206 ! CNS synaptic transmission [Term] id: MT:0002913 name: PNS synaptic transmission namespace: Trait.ontology def: "defect in the communication from a neuron to a target across a synapse in the peripheral nervous system" [MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0003635 ! synaptic transmission [Term] id: MT:0002914 name: endplate potential activity namespace: Trait.ontology def: "defect in the excitatory response of peripheral synapses to stimulation; these amplitudes are larger than central synapse potentials" [Principles of Neural Science_3rd edition:ISBN 0-8385-8034-3] synonym: "abnormal end plate potential activity" EXACT [] synonym: "abnormal EPP activity" EXACT [] is_a: MT:0002913 ! PNS synaptic transmission [Term] id: MT:0002915 name: synaptic depression namespace: Trait.ontology def: "changes in the duration of the reduction of effectiveness of synaptic connections between neurons and target after repetitive stimulation" [Principles of Neural Science_3rd edition:ISBN 0-8385-8034-3] is_a: MT:0002206 ! CNS synaptic transmission [Term] id: MT:0002918 name: paired-pulse facilitation namespace: Trait.ontology def: "defects in the response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to lack of increase of neurotransmitter release at the second stimulus" [Principles of Neural Science_3rd edition:ISBN 0-8385-8034-3] synonym: "abnormal PPF" EXACT [] is_a: MT:0002206 ! CNS synaptic transmission [Term] id: MT:0002921 name: post-tetanic potential namespace: Trait.ontology def: "defects in the size or duration of potentials that persist after tetanic stimulation of central synapses" [Principles of Neural Science_3rd edition:ISBN 0-8385-8034-3] synonym: "abnormal PTP" EXACT [] is_a: MT:0002206 ! CNS synaptic transmission [Term] id: MT:0002924 name: CNS synapse formation namespace: Trait.ontology def: "increase in time required to complete the process of generating connections between an axon and effector tissue or neuron " [MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0000913 ! brain development [Term] id: MT:0002926 name: aganglionic megacolon namespace: Trait.ontology def: "extreme dilation of the colon due to defects in innervation from the ganglia, or absence of the ganglia of the myenteric plexus" [RGD:Rat Genome Database submission, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002731 ! megacolon [Term] id: MT:0002927 name: toxic megacolon namespace: Trait.ontology def: "severe non-obstructive dilation of the colon" [RGD:Rat Genome Database submission, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002731 ! megacolon [Term] id: MT:0002928 name: bile duct morphology namespace: Trait.ontology def: "malformation of the channels that secrete bile from the liver to the gall bladder and intestines" [MeSH:National Library of Medicine_Medical Subject Headings, RGD:Rat Genome Database submission] synonym: "abnormal bile duct" EXACT [] is_a: MT:0005083 ! biliary tract morphology [Term] id: MT:0002929 name: bile duct development namespace: Trait.ontology def: "incomplete or aberrant differentiation of the channels that secrete bile from the liver to the gall bladder and intestines" [MeSH:National Library of Medicine_Medical Subject Headings, RGD:Rat Genome Database submission] is_a: MT:0002928 ! bile duct morphology is_a: MT:0003943 ! liver/biliary system development [Term] id: MT:0002931 name: glutaricadicuria namespace: Trait.ontology def: "an accumulation of an intermediate of tryptophan catabolism in the urine" [RGD:Rat Genome Database submission, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001757 ! urine chemistry [Term] id: MT:0002932 name: joint morphology namespace: Trait.ontology def: "defect in the articulation point of two or more bones" [MeSH:National Library of Medicine_Medical Subject Headings, RGD:Rat Genome Database submission] subset: slim_pig is_a: MT:0005508 ! skeleton morphology [Term] id: MT:0002933 name: joint inflammation namespace: Trait.ontology def: "local accumulation of fluid, plasma proteins, and leukocytes in the joints" [RGD:Rat Genome Database submission] is_a: MT:0001846 ! tissue specific inflammatory response is_a: MT:0002932 ! joint morphology [Term] id: MT:0002934 name: acute joint inflammation namespace: Trait.ontology def: "early and often transient reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into the joints; initiated by injury, infection, or local immune response " [RGD:Rat Genome Database submission] is_a: MT:0002933 ! joint inflammation [Term] id: MT:0002935 name: chronic joint inflammation namespace: Trait.ontology def: "persistent inflammatory response in the joints, often caused by persistent infection or during an autoimmune response" [RGD:Rat Genome Database submission] is_a: MT:0002933 ! joint inflammation [Term] id: MT:0002936 name: joint swelling namespace: Trait.ontology def: "enlargement of the joints, usually due to an accumulation of fluid" [RGD:Rat Genome Database submission] subset: slim_pig is_a: MT:0002932 ! joint morphology [Term] id: MT:0002937 name: synovial blood flow rate namespace: Trait.ontology def: "blood flow rate to the a synovial joint" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] is_a: MT:0001533 ! skeleton physiology is_a: MT:0002128 ! blood circulation [Term] id: MT:0002938 name: white spotting namespace: Trait.ontology def: "the appearance of patches of white fur" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0002075 ! coat color [Term] id: MT:0002939 name: head spot namespace: Trait.ontology def: "the appearance of a round area of white fur on the head" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0002938 ! white spotting [Term] id: MT:0002940 name: variable body spotting namespace: Trait.ontology alt_id: MT:0000369 def: "the appearance of patches of white fur at random on the coat" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] synonym: "white spotting" EXACT [] is_a: MT:0002938 ! white spotting [Term] id: MT:0002943 name: lactate dehydrogenase level namespace: Trait.ontology def: "aberrant concentration of this enzyme, which catalyzes the interconversion of lactate and pyruvate" [J:87714, pvb:Pierre Vanden Borre_Mouse Genome Informatics Curator] synonym: "abnormal LDH level" EXACT [] is_a: MT:0005319 ! enzyme/ coenzyme level [Term] id: MT:0002945 name: inhibitory postsynaptic currents namespace: Trait.ontology def: "defect in the size or duration of currents detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, Principles of Neural Science_3rd edition:ISBN 0-8385-8034-3] synonym: "abnormal IPSCs" EXACT [] is_a: MT:0002206 ! CNS synaptic transmission [Term] id: MT:0002946 name: time of axon outgrowth namespace: Trait.ontology def: "an increased amount of time required for an axon to extend from a neuron cell body and find the target" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, J:77048] is_a: MT:0003651 ! axon outgrowth [Term] id: MT:0002947 name: hemangioma namespace: Trait.ontology def: "proliferation of blood vessels leading to a mass that resembles a neoplasm" [J:87544, pvb:Pierre Vanden Borre_Mouse Genome Informatics Curator] synonym: "angioma" EXACT [] is_a: MT:0002019 ! tumor incidence [Term] id: MT:0002948 name: neuron specification namespace: Trait.ontology def: "defects in the developmental patterning of neurons resulting in ectopic placement, decreased numbers or absence of mature neurons" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, J:87948] is_a: MT:0002882 ! neuron [Term] id: MT:0002949 name: neural crest cells morphology/development namespace: Trait.ontology def: "defect in the transient and migratory group of cells that emerge from the dorsal region of the neural tube and disperse to many peripheral locations to form various tissues of the adult" [Principles of Neural Science_3rd edition:ISBN 0-8385-8034-3] is_a: MT:0002151 ! neural tube morphology/development [Term] id: MT:0002950 name: neural crest cell migration namespace: Trait.ontology def: "defect in the dispersion of the transient and migratory group of cells that emerge from the dorsal region of the neural tube and migrate to many peripheral locations to form various tissues of the adult" [Principles of Neural Science_3rd edition:ISBN 0-8385-8034-3] is_a: MT:0002949 ! neural crest cells morphology/development [Term] id: MT:0002954 name: aerobic energy metabolism namespace: Trait.ontology alt_id: MT:0005622 def: "defect in respiratory chain energy production (oxidative metabolism) process in all living cells where oxygen is consumed and carbon dioxide and water are produced" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal cell respiration" EXACT [] synonym: "abnormal mitochondrial energy production" EXACT [] synonym: "abnormal respiratory chain function" EXACT [] is_a: MT:0006036 ! mitochondrial physiology [Term] id: MT:0002956 name: compensatory renal growth namespace: Trait.ontology def: "decreased additional growth of a kidney upon removal of the other kidney through surgery or disease" [RGD:Rat Genome Database submission] is_a: MT:0002706 ! kidney size [Term] id: MT:0002957 name: intestinal adenocarcinoma namespace: Trait.ontology def: "malignant neoplasm of epithelial cells in the intestine" [pvb:Pierre Vanden Borre_Mouse Genome Informatics Curator] is_a: MT:0002038 ! carcinoma [Term] id: MT:0002958 name: aqueductal stenosis namespace: Trait.ontology def: "the most common form of obstructive hydrocephaly and results from narrowing of the aqueduct of Sylvius, which connects the third and fourth ventricles" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000917 ! obstructive hydrocephaly [Term] id: MT:0002960 name: microalbumin excretion namespace: Trait.ontology def: "less than the normal amount of fragments of this protein voided by the kidneys" [RGD:Rat Genome Database submission] is_a: MT:0005555 ! kidney excretion [Term] id: MT:0002961 name: axon guidance namespace: Trait.ontology def: "defect in the signaling mechanisms that allow precise navigation and connections of axonal growth cones to effector tissues " [Principles of Neural Science_3rd edition:ISBN 0-8385-8034-3] is_a: MT:0006008 ! neurogenesis [Term] id: MT:0002963 name: protein excretion namespace: Trait.ontology def: "less than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission] is_a: MT:0005555 ! kidney excretion [Term] id: MT:0002969 name: social transmission of food preference namespace: Trait.ontology is_a: MT:0002802 ! discrimination learning [Term] id: MT:0002970 name: white fat morphology namespace: Trait.ontology subset: slim_cattle subset: slim_pig is_a: MT:0000003 ! adipose tissue morphology [Term] id: MT:0002971 name: brown fat morphology namespace: Trait.ontology is_a: MT:0000003 ! adipose tissue morphology [Term] id: MT:0002972 name: cardiac muscle contractility namespace: Trait.ontology def: "ability of the heart muscle to shorten or to develop increased tension, often measured by dP/dT max" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] subset: slim_chkn is_a: MT:0001544 ! cardiovascular system physiology is_a: MT:0005620 ! muscle contractility [Term] id: MT:0002975 name: vascular smooth muscle size namespace: Trait.ontology def: "the physical dimensions, proportions, magnitude, or extent of the nonstriated, involuntary muscle tissue of the blood vessels" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] relationship: part_of MT:0005592 ! blood vessel smooth muscle morphology [Term] id: MT:0002979 name: vestibular response namespace: Trait.ontology is_a: MT:0000353 ! vestibular system physiology is_a: MT:0001525 ! balance [Term] id: MT:0002980 name: postural reflex namespace: Trait.ontology is_a: MT:0001961 ! reflex is_a: MT:0003492 ! involuntary movement [Term] id: MT:0002982 name: germ cell migration namespace: Trait.ontology def: "defects in the orderly movement of a germ cell, a cell specialized to produce haploid gametes, from one site to another during development" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0001919 ! reproductive system physiology [Term] id: MT:0002983 name: retinal ganglion cell number namespace: Trait.ontology def: "greater number of cells in the innermost nuclear layer of the retina, which projects axons through the optic nerve to the brain" [il:Ira Lu_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0000965 ! sensory neuron morphology is_a: MT:0005241 ! retinal ganglion layer morphology [Term] id: MT:0002985 name: urine calcium level namespace: Trait.ontology def: "any change in the level of excretion of calcium in the urine" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0001757 ! urine chemistry [Term] id: MT:0002987 name: urine osmolarity namespace: Trait.ontology def: "changes in the concentration of ions in the urine compared to the normal state" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, J:83000] is_a: MT:0001757 ! urine chemistry [Term] id: MT:0002990 name: ureter length namespace: Trait.ontology def: "reduced length of the tube that conducts the urine from the renal pelvis to the bladder" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0003585 ! ureter size [Term] id: MT:0002991 name: sebaceous gland physiology namespace: Trait.ontology def: "anomalous function of any of the small, sacculated organs found within the dermis that normally secrete sebum" [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "al sebaceous gland function" EXACT [] is_a: MT:0002164 ! gland physiology [Term] id: MT:0002992 name: sebaceous lipid secretion namespace: Trait.ontology def: "abnormal function of the sebaceous gland resulting in changes to the lipid profile secreted onto the hair and skin" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0002991 ! sebaceous gland physiology [Term] id: MT:0002993 name: arthritis namespace: Trait.ontology def: "joint inflammation, marked by changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures" [MeSH:National Library of Medicine_Medical Subject Headings, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "rheumatoid arthritis" EXACT [] is_a: MT:0002933 ! joint inflammation [Term] id: MT:0002995 name: primary sex reversal namespace: Trait.ontology def: "gonad type is not consistent with chromosomal sex" [llw2:Linda Washburn_Mouse Genome Informatics Curator] synonym: "sex-reversed gonad" EXACT [] is_a: MT:0002211 ! primary sex determination is_a: MT:0005652 ! sex reversal [Term] id: MT:0002996 name: ovotestis namespace: Trait.ontology def: "gonad with both ovarian and testicular tissue" [llw2:Linda Washburn_Mouse Genome Informatics Curator] is_a: MT:0002211 ! primary sex determination is_a: MT:0003936 ! reproductive system development [Term] id: MT:0002997 name: seminal gland size namespace: Trait.ontology def: "increased size, compared to the normal state, of one of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0002059 ! seminal gland morphology [Term] id: MT:0002998 name: bone remodeling namespace: Trait.ontology def: "aberrant process of the turnover of bone matrix that involves a balance of resorption and formation by osteoclasts and osteoblasts, respectively" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0001533 ! skeleton physiology [Term] id: MT:0002999 name: bone healing namespace: Trait.ontology def: "defects in the restoration of integrity to bone after trauma" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0002998 ! bone remodeling [Term] id: MT:0003000 name: susceptibility to lymphoma namespace: Trait.ontology def: "decreased likelihood of developing a neoplasm of any lymphoid tissue" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, J:87536, smb:Susan M. Bello] is_a: MT:0005514 ! susceptibility to tumor development [Term] id: MT:0003005 name: hippocampal fimbria morphology namespace: Trait.ontology def: "malformations in the flattened band of efferent fibers arising from the subiculum and medial border of the hippocampus, which then thickens to form the fornix and fibers of the hippocampal commissure" [MeSH:National Library of Medicine_Medical Subject Headings, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000807 ! hippocampus morphology [Term] id: MT:0003006 name: hippocampal fornix morphology namespace: Trait.ontology def: "malformations in the compact, white, heavily myelinated fiber bundle arising from the Ammon horn of the hippocampus in each cerebral hemisphere and projecting to the hypothalamus and the mammillary body" [MeSH:National Library of Medicine_Medical Subject Headings, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000807 ! hippocampus morphology [Term] id: MT:0003007 name: ectopic thymus namespace: Trait.ontology def: "ectopic location of the thymus primordium, which normally resides in the superior mediastinum and lower part of the neck" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, J:76015] is_a: MT:0000703 ! thymus morphology [Term] id: MT:0003009 name: cytokine secretion namespace: Trait.ontology def: "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0005049 ! cytokine physiology [Term] id: MT:0003010 name: mortality induced by ionizing radiation namespace: Trait.ontology def: "reduced sensitivity to lethal doses of ionizing radiation such as ultraviolet light, X-rays, or gamma rays" [J:88888, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0001657 ! induced morbidity/mortality [Term] id: MT:0003011 name: dark adaptation namespace: Trait.ontology def: "increase in time required for the eye to recover its sensitivity in the dark following exposure to bright lights" [hdene:Howard Dene_Mouse Genome Informatics Curator, J:68444] is_a: MT:0005253 ! eye physiology [Term] id: MT:0003013 name: renal integrity namespace: Trait.ontology def: "wasting of the kidney due to injury or disease resulting in reduced size" [J:88636, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0002136 ! kidney physiology [Term] id: MT:0003014 name: kidney medulla morphology namespace: Trait.ontology def: "anomalous structure of the inner portion of the kidney consisting of the renal pyramids" [J:88636, smb:Susan M. Bello_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal renal medulla" EXACT [] is_a: MT:0002135 ! kidney morphology [Term] id: MT:0003015 name: circulating bicarbonate level namespace: Trait.ontology def: "aberrant concentration of inorganic salts that contain the -HCO3 radical in the circulation, which are an important factor in regulating the pH of the blood " [MeSH:National Library of Medicine_Medical Subject Headings, RGD:Rat Genome Database submission] is_a: MT:0000179 ! blood chemistry [Term] id: MT:0003018 name: circulating chloride level namespace: Trait.ontology def: "aberrant concentration of chlorine salts in the circulation" [MeSH:National Library of Medicine_Medical Subject Headings, RGD:Rat Genome Database submission] is_a: MT:0000179 ! blood chemistry [Term] id: MT:0003021 name: coronary flow rate namespace: Trait.ontology def: "rate of blood flow in the blood vessels supplying the heart" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] is_a: MT:0000233 ! blood flow velocity [Term] id: MT:0003024 name: coronary artery patency namespace: Trait.ontology def: "any measurable characteristic pertaining to the openness of any of the blood vessels supplying the heart" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] relationship: part_of MT:0007053 ! coronary artery integrity [Term] id: MT:0003027 name: blood pH regulation namespace: Trait.ontology def: "anomaly in the function of the buffer systems of the blood in combination with the respiratory and renal systems that control the relative acidity or alkalinity of the blood, as measured by the concentration of the hydrogen ion" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, RGD:Rat Genome Database submission] is_a: MT:0000179 ! blood chemistry is_a: MT:0004043 ! pH regulation [Term] id: MT:0003028 name: alkalosis namespace: Trait.ontology def: "a pathological condition characterized by a decrease in the hydrogen ion concentration of arterial blood; caused by an increase in the concentration of alkaline compounds, or by a decrease in the concentration of acidic compounds or carbon dioxide to the body fluids" [MeSH:National Library of Medicine_Medical Subject Headings, RGD:Rat Genome Database submission, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0003027 ! blood pH regulation [Term] id: MT:0003029 name: alkalemia namespace: Trait.ontology def: "decreased concentration of H-ion in the blood or a rise in pH" [RGD:Rat Genome Database submission, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0003027 ! blood pH regulation [Term] id: MT:0003030 name: acidemia namespace: Trait.ontology def: "increased concentration of H-ion in the blood or a fall below normal in pH" [RGD:Rat Genome Database submission, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0003027 ! blood pH regulation [Term] id: MT:0003031 name: acidosis namespace: Trait.ontology def: "a pathological state characterized by an increase in the hydrogen ion concentration of arterial blood; caused by an decrease in the concentration of alkaline compounds, or by a increase in the concentration of acidic compounds or carbon dioxide to the body fluids" [MeSH:National Library of Medicine_Medical Subject Headings, RGD:Rat Genome Database submission, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0003027 ! blood pH regulation [Term] id: MT:0003033 name: pulmonary vascular resistance namespace: Trait.ontology def: "force opposing blood flow in the lung blood vessels" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] is_a: MT:0005532 ! vascular resistance [Term] id: MT:0003036 name: vertebral homeotic transformation namespace: Trait.ontology alt_id: MT:0000144 alt_id: MT:0000145 alt_id: MT:0000146 alt_id: MT:0000147 def: "homeotic transformation of a specific vertebrae to adopt the fate of another" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] synonym: "transformation of C7 to T1" NARROW [] synonym: "transformation of L6 to S1" NARROW [] synonym: "transformation of T7 to T8" NARROW [] synonym: "transformation of TX to L1" NARROW [] synonym: "vertebral transformation" EXACT [] is_a: MT:0000137 ! vertebrae morphology [Term] id: MT:0003044 name: basement membrane formation namespace: Trait.ontology def: "defect in the development of the extracellular supportive tissue closely adjacent to the basal surface of the epithelium of muscle cells, fat cells and Schwann cells, which is comprised of type IV collagen, laminin, and sulfated proteoglycans and other components" [MeSH:National Library of Medicine_Medical Subject Headings, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "impaired basement lamina formation" EXACT [] is_a: MT:0004272 ! basement membrane morphology [Term] id: MT:0003045 name: fibrosis namespace: Trait.ontology def: "invasion of fibrous connective tissue into any organ or multiple organs, often resulting from inflammation or injury " [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0005395 ! other trait [Term] id: MT:0003046 name: liver cirrhosis namespace: Trait.ontology def: "liver disease in which the occurrence of fibrotic nodules cause diffuse damage to parenchymal cells, disruptions in microcirculation, vascular anatomy and hepatic architecture, resulting in hepatic dysfunction and ultimately, hepatic failure" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000598 ! liver morphology [Term] id: MT:0003047 name: thoracic vertebrae morphology namespace: Trait.ontology def: "malformation of any or all of the thirteen bony segments of the spine located anterior to the lumbar vertebrae and posterior to the cervical vertebrae" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] subset: slim_cattle subset: slim_pig is_a: MT:0000137 ! vertebrae morphology [Term] id: MT:0003048 name: cervical vertebrae morphology namespace: Trait.ontology def: "malformation of any or all of the seven bony segments of the spine located anterior to the thoracic vertebrae" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0000137 ! vertebrae morphology [Term] id: MT:0003049 name: lumbar vertebrae morphology namespace: Trait.ontology def: "malformation of any or all of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] subset: slim_cattle subset: slim_pig is_a: MT:0000137 ! vertebrae morphology [Term] id: MT:0003050 name: sacral vertebrae morphology namespace: Trait.ontology def: "malformation of any or all of the four bony segments of the spine located posterior to the lumbar vertebrae and anterior to the caudal vertebrae" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0000137 ! vertebrae morphology [Term] id: MT:0003051 name: tail shape namespace: Trait.ontology def: "form of the tail" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0002111 ! tail morphology [Term] id: MT:0003052 name: omphalocele namespace: Trait.ontology def: "protrusion of abdominal viscera at the base of the umbilical cord, with a covering membranous sac of peritoneum-amnion" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "amniocele" EXACT [] synonym: "exomphalos" EXACT [] synonym: "exumbilication" EXACT [] synonym: "umbilical hernia" EXACT [] is_a: MT:0001725 ! umbilical cord morphology is_a: MT:0003257 ! abdominal wall morphology [Term] id: MT:0003054 name: spina bifida namespace: Trait.ontology def: "common congenital midline defect of fusion of the vertebral arch" [MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0000929 ! open neural tube [Term] id: MT:0003055 name: epiphyseal plate morphology namespace: Trait.ontology def: "malformed or absent cartilaginous center of ossification on the long bones permitting growth of the bone in both directions during development" [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal growth plate morphology" EXACT [] is_a: MT:0000163 ! cartilage morphology is_a: MT:0002113 ! skeleton development [Term] id: MT:0003056 name: hyoid bone morphology namespace: Trait.ontology def: "anomalous structure of the U-shaped bone lying between the mandible and the larynx that supports the tongue muscles" [hdene:Howard Dene_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal lingual bone" EXACT [] is_a: MT:0002116 ! craniofacial bone morphology [Term] id: MT:0003057 name: epicardium morphology namespace: Trait.ontology def: "any measurable or observable characteristic related to the shape, structure, color or pattern of the visceral layer of the pericardium that surrounds and attaches to all the surfaces of the heart" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] synonym: "lamina visceralis pericardii morphology" EXACT [] synonym: "morphology of the visceral layer of serous pericardium" EXACT [] xref: MP:0003057 relationship: part_of MT:0000288 ! pericardium morphology [Term] id: MT:0003061 name: aerobic running capacity namespace: Trait.ontology def: "reduced ability to run at defined speeds and/or distances compared to controls" [RGD:Rat Genome Database submission] is_a: MT:0000348 ! aerobic fitness [Term] id: MT:0003065 name: hepatic copper content namespace: Trait.ontology def: "anomalous level of copper present in the liver tissue" [RGD:Rat Genome Database submission] synonym: "abnormal liver copper concentration" EXACT [] is_a: MT:0000609 ! liver physiology is_a: MT:0003952 ! copper level [Term] id: MT:0003069 name: superior semicircular canal namespace: Trait.ontology def: "form or structure of the upper, superior segment of the long bony tube of the labyrinth that is involved in the sense of balance" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "anterior semicircular canal morphology" EXACT [] is_a: MT:0002428 ! semicircular canal [Term] id: MT:0003072 name: metatarsal bone morphology namespace: Trait.ontology def: "anomaly in the five bones of the hindpaws that articulate proximally with the cuneiform and cuboid bones of the tarsus and distally with the phalanges" [Anatomy of the Rat:Greene EC_Hafner Publishing Co_1935, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] subset: slim_chkn subset: slim_pig is_a: MT:0002115 ! skeleton extremities morphology [Term] id: MT:0003073 name: metacarpal bone morphology namespace: Trait.ontology def: "anomaly in the five bones of the forepaws that articulate proximally with the carpal bones and distally with the phalanges" [Anatomy of the Rat:Greene EC_Hafner Publishing Co_1935, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] subset: slim_pig is_a: MT:0002115 ! skeleton extremities morphology [Term] id: MT:0003074 name: metacarpal bone number namespace: Trait.ontology def: "number of bones of the forepaws/hands that articulate proximally with the carpal bones and distally with the phalanges" [Anatomy of the Rat:Greene EC_Hafner Publishing Co_1935, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0003073 ! metacarpal bone morphology [Term] id: MT:0003075 name: response to CNS ischemic injury namespace: Trait.ontology def: "abnormal response to loss of circulation in a region of the brain; may be induced or spontaneous" [smb:Susan M. Bello_Mouse Genome Informatics Curator] synonym: "response to stroke" EXACT [] is_a: MT:0006080 ! CNS ischemia [Term] id: MT:0003077 name: cell cycle namespace: Trait.ontology def: "failure to progress or abnormal progression through the stages of the cell cycle" [J:91266, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0005621 ! cell physiology [Term] id: MT:0003078 name: aphakia namespace: Trait.ontology def: "absence of the crystalline lens of the eye" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "absence of lens" EXACT [] synonym: "absent lens" EXACT [] is_a: MT:0001303 ! lens morphology [Term] id: MT:0003079 name: susceptibility to induced joint inflammation namespace: Trait.ontology def: "reduced or absent inflammatory response in the joints due to chemical or mechanical agents" [RGD:Rat Genome Database submission] is_a: MT:0002933 ! joint inflammation [Term] id: MT:0003080 name: NK cell cytolysis namespace: Trait.ontology def: "ability of these cells to destroy or dissolve targeted cells" [RGD:Rat Genome Database submission] is_a: MT:0005069 ! NK cell physiology [Term] id: MT:0003081 name: soleus morphology namespace: Trait.ontology def: "anomaly in the superficial flat broad muscle of the calf that is responsible for plantar flexion of the foot" [smb:Susan M. Bello_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0003358 ! hypaxial muscle morphology [Term] id: MT:0003082 name: gastrocnemius morphology namespace: Trait.ontology def: "anomaly in the two-headed large muscle of the posterior portion of the lower hindleg, the most superficial of the calf muscles" [smb:Susan M. Bello_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0003358 ! hypaxial muscle morphology [Term] id: MT:0003083 name: tibialis anterior morphology namespace: Trait.ontology def: "anomaly in the muscle of the shin that is responsible for dorsiflexion and inversion of the foot" [smb:Susan M. Bello_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0003358 ! hypaxial muscle morphology [Term] id: MT:0003084 name: skeletal muscle fiber morphology namespace: Trait.ontology def: "anomalous structure of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [smb:Susan M. Bello_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] subset: slim_pig is_a: MT:0000759 ! skeletal muscle morphology is_a: MT:0004087 ! muscle fiber morphology [Term] id: MT:0003085 name: egg cylinder morphology namespace: Trait.ontology def: "anomaly in the transient cup-like structure of the epiblast that consists of a single layer of embryonic cells" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0002085 ! embryonic tissue morphology [Term] id: MT:0003086 name: hydromyelia namespace: Trait.ontology def: "increased fluid in the central canal of the spinal cord" [J:57948, smb:Susan M. Bello_Mouse Genome Informatics Curator] synonym: "hydrorrhachis" EXACT [] is_a: MT:0000254 ! cerebrospinal fluid volume is_a: MT:0000955 ! spinal cord morphology [Term] id: MT:0003088 name: prepulse inhibition namespace: Trait.ontology def: "increase or decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [J:91131, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0002206 ! CNS synaptic transmission [Term] id: MT:0003090 name: muscle progenitor cell migration namespace: Trait.ontology def: "defects in the movement of cells that will develop into muscle cells out of the somites and/or to the appropriate location in the body" [smb:Susan M. Bello_Mouse Genome Informatics Curator] synonym: "abnormal myogenic progenitor cell migration" EXACT [] is_a: MT:0000729 ! myogenesis [Term] id: MT:0003091 name: cell migration namespace: Trait.ontology def: "defect in the movement of cells during developmental processes" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0005384 ! cellular trait [Term] id: MT:0003092 name: corneal stroma thickness namespace: Trait.ontology def: "reduced width of the lamellated connective tissue layer of the cornea" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, J:81616] is_a: MT:0005300 ! corneal stroma morphology is_a: MT:0005543 ! corneal thickness [Term] id: MT:0003093 name: anterior stroma morphology namespace: Trait.ontology def: "structural anomaly of the anterior segment of the lamellated connective tissue layer of the cornea" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, J:81616, MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0005300 ! corneal stroma morphology [Term] id: MT:0003094 name: posterior stroma morphology namespace: Trait.ontology def: "structural anomaly of the posterior segment of the lamellated connective tissue layer of the cornea" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, J:81616, MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0005300 ! corneal stroma morphology [Term] id: MT:0003095 name: corneal stroma development namespace: Trait.ontology def: "anomalous differentiation of the lamellated connective tissue layer of the cornea" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, J:81616] is_a: MT:0001286 ! eye development is_a: MT:0005300 ! corneal stroma morphology [Term] id: MT:0003096 name: corneal light-scattering namespace: Trait.ontology def: "anomaly in the normal transmission of light through the cornea; light is reflected or absorbed instead; often due to anomalies in the arrangement of lamella in the corneal stroma" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, J:81616] is_a: MT:0005253 ! eye physiology [Term] id: MT:0003097 name: tendon stiffness namespace: Trait.ontology def: "altered ability of tendon to maintain tensile strength and load" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0002106 ! muscle physiology [Term] id: MT:0003099 name: retinal detachment namespace: Trait.ontology def: "detachment of the retina from the underlying inner wall of the eye, often from tension of the vitreous; may occur with aging or as a result of trauma" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, J:83544] synonym: "detached retina" EXACT [] synonym: "retinal tear" EXACT [] is_a: MT:0001325 ! retina morphology [Term] id: MT:0003100 name: myopia namespace: Trait.ontology def: "optical condition in which only rays from a finite distance from the eye focus on the retina" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, J:83544] synonym: "near sight" EXACT [] synonym: "nearsightedness" EXACT [] synonym: "short sight" EXACT [] synonym: "shortsightedness" EXACT [] is_a: MT:0002090 ! vision [Term] id: MT:0003101 name: high myopia namespace: Trait.ontology def: "an optical condition involving enlarging of the eye, scleral thinning and frequent detachment of the retina resulting from stress associated with excessive axial elongation" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, J:83544] is_a: MT:0003100 ! myopia [Term] id: MT:0003102 name: sclera thickness namespace: Trait.ontology def: "reduction in the width of the fibrous, outer envelope of the eyeball, the sclera may appear blue as a result of the underlying epithelium showing through" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, J:83544] synonym: "blue sclera" EXACT [] is_a: MT:0002698 ! sclera morphology [Term] id: MT:0003103 name: liver integrity namespace: Trait.ontology def: "deterioration of the liver due to injury or disease, often accompanied by loss of function" [J:91653, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0000609 ! liver physiology [Term] id: MT:0003104 name: skull size namespace: Trait.ontology def: "volume or area of the skull" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, J:33716] synonym: "absent skull" EXACT [] is_a: MT:0000438 ! skull morphology [Term] id: MT:0003105 name: heart atrium morphology namespace: Trait.ontology def: "any measurable or observable characteristic related to the shape, structure, color or pattern of the upper chamber(s) of the heart that recieve blood from the vasculature and send blood into a ventricle" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] synonym: "cardiac atrial morphology" RELATED [] synonym: "cardiac atrium morphology" RELATED [] relationship: part_of MT:0000266 ! cardiac morphology [Term] id: MT:0003107 name: response to novelty namespace: Trait.ontology subset: slim_chkn subset: slim_pig is_a: MT:0002572 ! emotion/affect behavior [Term] id: MT:0003110 name: malleal processus brevis morphology namespace: Trait.ontology def: "form or structure of the part of the malleus that contacts the upper part of the tympanic membrane where the tympanic cavity makes a deep pocket (epitympanic pocket) surrounding this cartilaginous nodule" [PMID:12701100] is_a: MT:0000029 ! malleus morphology [Term] id: MT:0003111 name: nucleus morphology namespace: Trait.ontology def: "abnormalities in the nucleus and/or its surrounding membrane" [J:91473, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0000358 ! cell content/ morphology [Term] id: MT:0003112 name: parathyroid gland size namespace: Trait.ontology def: "increased size of the two small, paired endocrine glands, usually found embedded in the connective tissue capsule on the posterior surface of the thyroid gland; they secrete parathyroid hormone (PTH) that regulates calcium and phosphorous metabolism" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000678 ! parathyroid gland morphology [Term] id: MT:0003114 name: pigmented parathyroid gland namespace: Trait.ontology def: "presence of melanocytes and/or melanin in either of the two small, paired endocrine glands, usually found embedded in the connective tissue capsule on the posterior surface of the thyroid gland; they secrete parathyroid hormone (PTH) that regulates calcium and phosphorous metabolism" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000678 ! parathyroid gland morphology [Term] id: MT:0003115 name: respiratory system development namespace: Trait.ontology def: "aberrant differentiation of pulmonary tissues" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002132 ! respiratory system morphology [Term] id: MT:0003116 name: rickets namespace: Trait.ontology def: "overproduction and deficient calcification of osteoid tissue due to vitamin D deficiency; can lead to skeletal deformities, growth defects, hypocalcemia, and sometimes tetany; skeletal fractures occur frequently" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002896 ! bone mineralization [Term] id: MT:0003117 name: tracheal-esophageal septation namespace: Trait.ontology def: "partial or complete failure of the trachea and esophagus to separate during development" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0003115 ! respiratory system development is_a: MT:0003119 ! digestive system development [Term] id: MT:0003118 name: tracheal-bronchial branching morphogenesis namespace: Trait.ontology def: "partial or complete failure of the trachea and bronchi to repeatedly divide during development of the lung" [J:91723, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0003115 ! respiratory system development is_a: MT:0003119 ! digestive system development [Term] id: MT:0003119 name: digestive system development namespace: Trait.ontology def: "dysmorphology of the organ system that converts ingested food to nutrients and energy" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0000462 ! digestive system morphology [Term] id: MT:0003120 name: tracheal cartilage morphology namespace: Trait.ontology def: "any structural anomaly of the cartilaginous structures that support the trachea" [J:97123, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0002282 ! trachea morphology [Term] id: MT:0003121 name: genomic imprinting namespace: Trait.ontology def: "phenotype resulting from inactivation of specific loci during gametogenesis, but not encoded by the DNA itself" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, llw2:Linda Washburn_Mouse Genome Informatics Curator] is_a: MT:0005395 ! other trait [Term] id: MT:0003122 name: maternal imprinting namespace: Trait.ontology def: "specific loci are inactivated during oogenesis and are not expressed in offspring" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, llw2:Linda Washburn_Mouse Genome Informatics Curator] is_a: MT:0003121 ! genomic imprinting [Term] id: MT:0003123 name: paternal imprinting namespace: Trait.ontology def: "specific loci are inactivated during spermatogenesis and are not expressed in offspring " [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, llw2:Linda Washburn_Mouse Genome Informatics Curator] is_a: MT:0003121 ! genomic imprinting [Term] id: MT:0003124 name: hypospadia namespace: Trait.ontology def: "a urethral opening located below the normal location; in males, the opening is usually on the ventral surface of the penis, and in females, the opening is usually in the vagina" [J:91491, MeSH:National Library of Medicine_Medical Subject Headings] synonym: "hypospadis" EXACT [] is_a: MT:0000537 ! urethra morphology [Term] id: MT:0003125 name: septation of the cloaca namespace: Trait.ontology def: "absence of or reduction in the separation of the single opening of the digestive, urinary, and reproductive tracts (cloaca) into multiple isolated openings during development, may result in hypospadia, reduced anogenital distance, or persistent cloaca" [J:91491, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0003119 ! digestive system development is_a: MT:0003936 ! reproductive system development is_a: MT:0003942 ! urinary system development [Term] id: MT:0003126 name: vulva morphology namespace: Trait.ontology def: "anomaly in the structure of the external genitalia of the female" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001119 ! female reproductive anatomy [Term] id: MT:0003127 name: clitoris morphology namespace: Trait.ontology def: "anomaly in the structure of the small, erectile body located at the anterior end of the vulva" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0003126 ! vulva morphology [Term] id: MT:0003128 name: splayed clitoris namespace: Trait.ontology def: "flattened or spread out clitoris" [J:91491, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0003127 ! clitoris morphology [Term] id: MT:0003129 name: persistent cloaca namespace: Trait.ontology def: "the presence of a single external opening to which the urinary, digestive and reproductive tracts all connect" [J:91491, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0000516 ! urinary system morphology is_a: MT:0003125 ! septation of the cloaca is_a: MT:0003936 ! reproductive system development [Term] id: MT:0003130 name: anal atresia namespace: Trait.ontology def: "absence of a connection between the anal pit and the rectum" [J:91491, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0000492 ! rectum morphology is_a: MT:0005034 ! anus morphology [Term] id: MT:0003132 name: pre-B cell number namespace: Trait.ontology def: "greater number of progenitor cells that form the B cell component of the immune system" [Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7, J:91592, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0002403 ! pre-B cell morphology/development [Term] id: MT:0003133 name: early pro-B cell number namespace: Trait.ontology def: "greater number of cells in the B lymphocyte lineage that undergo D-J rearrangement of the immunoglobulin heavy chain" [Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7, J:91592, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0005019 ! early pro-B cell morphology/development [Term] id: MT:0003134 name: late pro-B cell number namespace: Trait.ontology def: "greater number of the cells in the B lymphocyte lineage that undergo V-DJ rearrangement of the immunoglobulin heavy chain" [Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7, J:91592, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0005020 ! late pro-B cell morphology/development [Term] id: MT:0003135 name: erythrocyte precursor number namespace: Trait.ontology def: "greater numbers of progenitors of the erythrocyte lineage" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0002424 ! reticulocyte morphology/development [Term] id: MT:0003136 name: yellow coat color namespace: Trait.ontology def: "amount and distribution of yellow pigment (phaeomelanin) relative to black or brown pigment (eumelanin) is increased compared to wild-type agouti" [llw2:Linda L. Washburn_Mouse Genome Informatics Curator] is_a: MT:0002075 ! coat color [Term] id: MT:0003137 name: impulse conducting system function namespace: Trait.ontology def: "function of the impulse-conducting system composed of modified cardiac muscle and having the power of spontaneous rhythmicity and conduction more highly developed than the rest of the heart" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] is_a: MT:0001544 ! cardiovascular system physiology [Term] id: MT:0003140 name: atrium size namespace: Trait.ontology def: "the physical dimensions, proportions, magnitude, or extent of the upper chamber(s) of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] synonym: "atrial size" RELATED [] relationship: part_of MT:0003105 ! heart atrium morphology relationship: part_of MT:0005406 ! heart size [Term] id: MT:0003141 name: heart tissue composition namespace: Trait.ontology def: "any measurable or observable characteristic pertaining to the types and ratios of cells within the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator", RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] synonym: "cardiac tissue composition" RELATED [] relationship: part_of MT:0000266 ! cardiac morphology [Term] id: MT:0003143 name: otolith size namespace: Trait.ontology def: "average diameter or volume of the crystalline calciferous particles adhering to the otolithic membrane" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, J:67072] synonym: "ear crystal size" EXACT [] synonym: "otoconia size" EXACT [] synonym: "statoconia size" EXACT [] synonym: "statolith size" EXACT [] is_a: MT:0002894 ! otolith morphology [Term] id: MT:0003144 name: otolith number namespace: Trait.ontology def: "average number of the crystalline calciferous particles adhering to the otolithic membrane" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, J:30611] synonym: "decreased number of otoliths" EXACT [] synonym: "reduced number of otoconia" EXACT [] is_a: MT:0002894 ! otolith morphology [Term] id: MT:0003145 name: otolithic membrane integrity namespace: Trait.ontology def: "susceptibility of the otolithic (otoconial) membrane to detach from the underlying neuroepithelium" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, J:60193] is_a: MT:0002895 ! otolithic membrane morphology [Term] id: MT:0003148 name: cochlear coiling namespace: Trait.ontology def: "number of turns in the cochlea; in wild-type mice, the cochlea most commonly exhibits one and three-fourth turns" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, J:56294] is_a: MT:0000031 ! cochlea morphology [Term] id: MT:0003149 name: tectorial membrane morphology namespace: Trait.ontology def: "form or structure of the overlaying membrane of cochlear duct, an extracellular matrix of the inner ear that contacts the stereocilia bundles of specialized sensory hair cells; sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia, and leads to fluctuations in hair cell membrane potential, transducing sound into electrical signals" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, J:77634] is_a: MT:0003169 ! scala media morphology [Term] id: MT:0003150 name: tectorial membrane integrity namespace: Trait.ontology def: "tendency of the tectorial membrane to detach from the cochlear epithelium or spiral limbus" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, J:77634] is_a: MT:0003149 ! tectorial membrane morphology [Term] id: MT:0003151 name: tunnel of Corti morphology namespace: Trait.ontology def: "form or structure of the triangular, fluid-filled space normally found between the inner and outer rows of supporting pillar cells in the organ of Corti" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, J:32991] is_a: MT:0000042 ! organ of Corti [Term] id: MT:0003152 name: pillar cell differentiation namespace: Trait.ontology def: "process by which cells attain the specialized charateristics of the supporting cells that form the inner and outer walls of the tunnel in the organ of Corti" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, J:32991] is_a: MT:0004300 ! organ of Corti supporting cell morphology [Term] id: MT:0003154 name: soft palate namespace: Trait.ontology def: "abnormality in the musculomembranous fold that partly separates the mouth and pharynx, located behind the hard palate" [smb:Susan M. Bello_Mouse Genome Informatics Curator] synonym: "abnormal velum" EXACT [] synonym: "abnormal velum palatinum" EXACT [] is_a: MT:0003755 ! palate [Term] id: MT:0003155 name: telomere length namespace: Trait.ontology def: "abnormal length of the terminal section of a chromosome which has a specialized structure and which is involved in chromosomal replication and stability; normal length is a few hundred base pairs" [hdene:Howard Dene_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0003702 ! chromosome morphology [Term] id: MT:0003156 name: lymphocyte migration/homing namespace: Trait.ontology def: "altered ability of blood lymphocytes to bind to high endothelial venules (HEV), tether and roll along the luminal aspects of HEV, and migrate into the lymph nodes" [acv:Alicia Valenzuela_Genetic Resources Curator, J:92231] is_a: MT:0002442 ! leukocyte physiology [Term] id: MT:0003158 name: ease of swallowing namespace: Trait.ontology def: "difficulty in swallowing food or liquid" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "impaired swallowing" EXACT [] is_a: MT:0001663 ! digestive system physiology [Term] id: MT:0003159 name: esophageal smooth muscle morphology namespace: Trait.ontology def: "structural anomaly of the nonstriated, involuntary muscle tissue lining the esophagus" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0000767 ! smooth muscle morphology [Term] id: MT:0003160 name: esophageal development namespace: Trait.ontology def: "aberrant formation of the part of the digestive canal through which food passes from the pharynx to the stomach" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0000467 ! esophagus morphology is_a: MT:0003119 ! digestive system development [Term] id: MT:0003162 name: lateral semicircular canal size namespace: Trait.ontology def: "area or volume of the lateral long bony tube of the labyrinth that is involved in the sense of balance " [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0000037 ! lateral semicircular canal [Term] id: MT:0003164 name: posterior semicircular canal size namespace: Trait.ontology def: "area or volume of the posterior segment of the long bony tube of the labyrinth that is involved in the sense of balance" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002858 ! posterior semicircular canal [Term] id: MT:0003166 name: superior semicircular canal size namespace: Trait.ontology def: "area or volume of the upper, superior segment of the long bony tube of the labyrinth that is involved in the sense of balance" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "anterior semicircular canal size" EXACT [] is_a: MT:0003069 ! superior semicircular canal [Term] id: MT:0003167 name: scala tympani morphology namespace: Trait.ontology def: "form of structure of the division of the spiral canal of the cochlea lying on the basal side of the spiral lamina" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, J:56294] is_a: MT:0000031 ! cochlea morphology [Term] id: MT:0003168 name: scala vestibuli morphology namespace: Trait.ontology def: "form or structure of the division of the spiral canal of the cochlea lying on the apical side of the spiral lamina and vestibular membrane" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] synonym: "perilymphatic space morphology" EXACT [] synonym: "vestibular canal morphology" EXACT [] synonym: "vestibular chamber morphology" EXACT [] is_a: MT:0000031 ! cochlea morphology [Term] id: MT:0003169 name: scala media morphology namespace: Trait.ontology def: "form or structure of the division of the spiral canal of the cochlea that contains the organ of Corti (the neuroepithelial receptor organ for hearing)" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, J:23837, J:46972] synonym: "cochlear chamber morphology" EXACT [] synonym: "cochlear duct morphology" EXACT [] synonym: "Lowenberg scala morphology" EXACT [] is_a: MT:0000031 ! cochlea morphology [Term] id: MT:0003170 name: susceptibility to stomach tumor namespace: Trait.ontology def: "reduced likelihood of developing an abnormal growth of gastric tissue" [RGD:Rat Genome Database submission] synonym: "resistance to gastric tumor" EXACT [] is_a: MT:0005514 ! susceptibility to tumor development [Term] id: MT:0003172 name: lysosome physiology namespace: Trait.ontology def: "ability of lysosomes to produce enzymes necessary for digestion of exogenous material is impaired" [llw2:Linda Washburn_Mouse Genome Informatics Curator] is_a: MT:0005621 ! cell physiology [Term] id: MT:0003173 name: lysosomal enzyme secretion namespace: Trait.ontology def: "production of glycoprotein hydrolytic enzymes is decreased compared to normal" [llw2:Linda Washburn_Mouse Genome Informatics Curator] synonym: "reduced lysosomal enzyme secretion" EXACT [] is_a: MT:0003172 ! lysosome physiology [Term] id: MT:0003178 name: left pulmonary isomerism namespace: Trait.ontology def: "bilaterally symmetric left lung pattern (or altered asymmetric patterning of the lung)" [J:93051, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0000542 ! left-sided isomerism is_a: MT:0001175 ! lung morphology [Term] id: MT:0003179 name: platelet count namespace: Trait.ontology alt_id: MT:0002749 def: "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, hdene:Howard Dene_Mouse Genome Informatics Curator, J:93052] synonym: "reduced platelet count" EXACT [] synonym: "thrombocytopenia" EXACT [] synonym: "thrombopenia" EXACT [] is_a: MT:0000228 ! thrombopoiesis [Term] id: MT:0003180 name: pulmonary endothelial cell surface area namespace: Trait.ontology def: "area of the semipermeable membrane that encloses the cytoplasm of a pulmonary endothelial cell" [ms:mary shimoyama] relationship: part_of MT:0000484 ! pulmonary artery morphology relationship: part_of MT:0004007 ! lung blood vessel morphology relationship: part_of MT:0006055 ! blood vessel endothelial cell morphology [Term] id: MT:0003183 name: peptide metabolism namespace: Trait.ontology def: "anomaly in the biochemical modification and homeostasis of molecules consisting of linked amino acids and their derivatives" [RGD:Rat Genome Database submission] is_a: MT:0005621 ! cell physiology [Term] id: MT:0003185 name: angiotensin I-converting enzyme activity namespace: Trait.ontology def: "reduced activity of the exopeptidase that catalyses the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor, and is also involved in the inactivation of bradykinin" [RGD:Rat Genome Database submission] synonym: "decreased ACE activity" EXACT [] is_a: MT:0003183 ! peptide metabolism [Term] id: MT:0003186 name: redox activity namespace: Trait.ontology def: "defect in the processes that maintain the redox environment of a cell or compartment within a cell " [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0005621 ! cell physiology [Term] id: MT:0003189 name: fused joints namespace: Trait.ontology def: "partial or complete absence of the articulation point of two or more bones" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0002932 ! joint morphology [Term] id: MT:0003190 name: fused synovial joints namespace: Trait.ontology def: "partial or complete absence of separations containing synovial fluid between bones" [J:93028, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0003189 ! fused joints [Term] id: MT:0003191 name: cellular cholesterol metabolism namespace: Trait.ontology def: "impaired regulation of cellular cholesterol levels" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0005621 ! cell physiology [Term] id: MT:0003193 name: cholesterol efflux namespace: Trait.ontology def: "reduced level of removal of excess cholesterol from cells by an active transport pathway" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, RGD:Rat Genome Database submission] is_a: MT:0003191 ! cellular cholesterol metabolism [Term] id: MT:0003194 name: frequency of paradoxical sleep namespace: Trait.ontology synonym: "abnormal frequency of REM sleep" EXACT [] is_a: MT:0001501 ! sleep pattern [Term] id: MT:0003195 name: calcinosis namespace: Trait.ontology def: "pathologic deposition of calcium salts in tissues " [MeSH:National Library of Medicine_Medical Subject Headings, RGD:Rat Genome Database submission] is_a: MT:0005395 ! other trait [Term] id: MT:0003196 name: skin calcification namespace: Trait.ontology def: "pathologic deposition of calcium salts in the skin" [MeSH:National Library of Medicine_Medical Subject Headings, RGD:Rat Genome Database submission] is_a: MT:0005501 ! skin physiology [Term] id: MT:0003197 name: kidney calcification namespace: Trait.ontology def: "pathologic deposition of calcium salts in the kidney" [MeSH:National Library of Medicine_Medical Subject Headings, RGD:Rat Genome Database submission] is_a: MT:0002136 ! kidney physiology [Term] id: MT:0003198 name: tendon calcification namespace: Trait.ontology def: "pathologic deposition of calcium salts in the tendons" [MeSH:National Library of Medicine_Medical Subject Headings, RGD:Rat Genome Database submission] is_a: MT:0001533 ! skeleton physiology [Term] id: MT:0003199 name: muscle calcification namespace: Trait.ontology def: "pathologic deposition of calcium salts in muscle" [MeSH:National Library of Medicine_Medical Subject Headings, RGD:Rat Genome Database submission] is_a: MT:0002106 ! muscle physiology [Term] id: MT:0003200 name: joint calcification namespace: Trait.ontology def: "pathologic deposition of calcium salts in the joints" [MeSH:National Library of Medicine_Medical Subject Headings, RGD:Rat Genome Database submission] is_a: MT:0001533 ! skeleton physiology [Term] id: MT:0003201 name: extremity edema namespace: Trait.ontology def: "an accumulation of serous fluid in the limbs, paws and tail" [RGD:Rat Genome Database submission] is_a: MT:0001785 ! edema [Term] id: MT:0003202 name: neuron apoptosis namespace: Trait.ontology def: "change in the timing or the number of neurons undergoing programmed cell death" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0002882 ! neuron [Term] id: MT:0003207 name: cellular sensitivity to gamma-irradiation namespace: Trait.ontology def: "decreased incidence of cell death following exposure to high levels of gamma-irradiation" [J:92917, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0004228 ! cellular sensitivity to ionizing radiation [Term] id: MT:0003208 name: neuromere morphology namespace: Trait.ontology def: "malformation of the segments of the developing neural tube" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0002151 ! neural tube morphology/development [Term] id: MT:0003209 name: pulmonary elastic fiber morphology namespace: Trait.ontology def: "malformation of a slender connective tissue fiber in pulmonary tissue characterized by great elasticity" [RGD:Rat Genome Database submission, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001175 ! lung morphology [Term] id: MT:0003210 name: heart elastic fiber morphology namespace: Trait.ontology def: "any measurable or observable characteristic related to the shape, structure, color or pattern of the slender connective tissue fiber in cardiac tissue characterized by great elasticity" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator", RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] synonym: "cardiac elastic fiber morphology" RELATED [] xref: MP:0003210 relationship: part_of MT:0000266 ! cardiac morphology [Term] id: MT:0003211 name: aorta elastic tissue morphology namespace: Trait.ontology def: "any measurable or observable characteristic related to the shape, structure, color or pattern of the slender connective tissue fiber in aortic tissue characterized by great elasticity" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] synonym: "aortic elastic fiber morphology" RELATED [] relationship: part_of MT:0000272 ! aorta morphology relationship: part_of MT:0006083 ! blood vessel elastic tissue morphology [Term] id: MT:0003212 name: susceptibility to age related obesity namespace: Trait.ontology def: "probability of excessive weight gain that is progressive with age" [RGD:Rat Genome Database submission] is_a: MT:0005456 ! weight gain [Term] id: MT:0003214 name: neurofibrillary tangles namespace: Trait.ontology def: "dense intraneuronal accumulations of helical filaments (neurofilaments and microtubules) that assume twisted contorted patterns; found in subclasses of cells of the neocortex, hippocampus, brain stem, and diencephalon in individuals with Alzheimer disease and other tauopathies" [MeSH:National Library of Medicine_Medical Subject Headings, RGD:Rat Genome Database submission, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002152 ! brain morphology [Term] id: MT:0003215 name: renal interstitial fibrosis namespace: Trait.ontology def: "formation of fibrous tissue within the interstices of the kidney as a result of repair or a reactive process" [RGD:Rat Genome Database submission] is_a: MT:0003985 ! renal fibrosis [Term] id: MT:0003224 name: neuron integrity namespace: Trait.ontology def: "a retrogressive impairment of function or destruction of the functional cells of the nervous system that receive, conduct, and transmit impulses " [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002229 ! neural integrity [Term] id: MT:0003225 name: axonal dystrophy namespace: Trait.ontology def: "axon degeneration resulting from inadequate or faulty metabolism" [RGD:Rat Genome Database submission] is_a: MT:0005405 ! axon integrity [Term] id: MT:0003228 name: sinus venosus morphology namespace: Trait.ontology def: "any measurable or observable characteristic related to the shape, structure, color or pattern of the cavity at the caudal end of the embryonic cardiac tube in which the veins from the intra- and extraembryonic circulatory arcs unite; in the adult this becomes the portion of the right atrium known as the sinus of the vena cava" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] relationship: part_of MT:0000267 ! heart development [Term] id: MT:0003229 name: vitelline vascular morphology namespace: Trait.ontology def: "malformation in the vessels of the yolk sac" [J:93257, smb:Susan M. Bello_Mouse Genome Informatics Curator] synonym: "abnormal yolk sac vasculature" EXACT [] is_a: MT:0001718 ! yolk sac morphology [Term] id: MT:0003231 name: placental vascular morphology namespace: Trait.ontology def: "malformation in the vessels of the placenta" [J:93157, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0001711 ! placenta morphology [Term] id: MT:0003232 name: forebrain development namespace: Trait.ontology def: "anomaly in the formation or patterning of the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [J:93081, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0000783 ! forebrain morphology is_a: MT:0000913 ! brain development [Term] id: MT:0003235 name: alisphenoid bone morphology namespace: Trait.ontology def: "malformation in either of the broad curved wing like expanses on each side of the sphenoid bone in adults; may exist independently in the young" [J:93183, smb:Susan M. Bello_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000104 ! sphenoid bone morphology [Term] id: MT:0003236 name: lens capsule morphology namespace: Trait.ontology def: "malformation in the elastic, clear, membrane-like structure, that is outer most layer of the lens" [J:93301, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0001303 ! lens morphology [Term] id: MT:0003237 name: lens epithelium morphology namespace: Trait.ontology def: "malformation in the one or more of the layers of epithelial cells in the lens" [J:93301, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0001303 ! lens morphology [Term] id: MT:0003239 name: REM rate namespace: Trait.ontology synonym: "fast rapid eye movement" EXACT [] is_a: MT:0001501 ! sleep pattern [Term] id: MT:0003240 name: hippocampal neuron number namespace: Trait.ontology def: "loss of neurons in the hippocampal region of the brain, commonly due to an apoptotic event" [RGD:Rat Genome Database submission] comment: note Charles W. considered this a distinct term from degeneration is_a: MT:0000807 ! hippocampus morphology [Term] id: MT:0003241 name: cerebral cortex neuron number namespace: Trait.ontology def: "loss of neurons in the cortex region of the brain, commonly due to an apoptotic event" [RGD:Rat Genome Database submission] comment: Note that charles w. considers this distinct from degeneration is_a: MT:0000788 ! cerebral cortex morphology [Term] id: MT:0003242 name: basal ganglia neuron number namespace: Trait.ontology def: "loss of neurons in the basal ganglia of the brain, commonly due to an apoptotic event" [RGD:Rat Genome Database submission] comment: Note that Charles W. considers this distinct from degeneration is_a: MT:0006007 ! basal ganglion morphology [Term] id: MT:0003243 name: dopaminergic neuron morphology namespace: Trait.ontology def: "malformation or absence of the neurons that utilize dopamine as a neurotransmitter " [Principles of Neural Science_3rd edition:ISBN 0-8385-8034-3] is_a: MT:0002882 ! neuron [Term] id: MT:0003244 name: dopaminergic neuron number namespace: Trait.ontology def: "loss of the neurons that utilize dopamine as a neurotransmitter, commonly due to an apoptotic event" [RGD:Rat Genome Database submission] is_a: MT:0003243 ! dopaminergic neuron morphology [Term] id: MT:0003245 name: GABA neuron morphology namespace: Trait.ontology def: "malformation or absence of the neurons that utilize gamma-aminobutyric acid as a neurotransmitter " [Principles of Neural Science_3rd edition:ISBN 0-8385-8034-3] synonym: "abnormal GABA neurons" EXACT [] is_a: MT:0002882 ! neuron [Term] id: MT:0003246 name: GABA neuron number namespace: Trait.ontology def: "loss of the neurons that utilize gamma-aminobutyric acid as a neurotransmitter, commonly due to an apoptotic event" [RGD:Rat Genome Database submission] is_a: MT:0003245 ! GABA neuron morphology [Term] id: MT:0003247 name: glutaminergic neuron namespace: Trait.ontology def: "malformation or absence of the neurons that utilize glutamate as a neurotransmitter " [Principles of Neural Science_3rd edition:ISBN 0-8385-8034-3] is_a: MT:0002882 ! neuron [Term] id: MT:0003248 name: glutamate neuron number namespace: Trait.ontology def: "loss of the neurons that utilize glutamate as a neurotransmitter, commonly due to an apoptotic event" [RGD:Rat Genome Database submission] is_a: MT:0003247 ! glutaminergic neuron [Term] id: MT:0003249 name: muscle free fatty acid level namespace: Trait.ontology def: "higher than normal muscle level of organic, monobasic acids derived from hydrocarbons; they are saturated and unsaturated" [MeSH:National Library of Medicine_Medical Subject Headings, RGD:Rat Genome Database submission] synonym: "elevated muscle free fatty acid (FFA)" EXACT [] is_a: MT:0002106 ! muscle physiology [Term] id: MT:0003251 name: gall bladder inflammation namespace: Trait.ontology def: "local accumulation of fluid, plasma proteins, and leukocytes in the gall bladder" [ncbi:Matthew Mailman_NCBI request, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001846 ! tissue specific inflammatory response is_a: MT:0005085 ! gall bladder physiology [Term] id: MT:0003252 name: bile duct physiology namespace: Trait.ontology def: "anomalous action or function of the channels that secrete bile from the liver to the gall bladder and intestines" [ncbi:Matthew Mailman_NCBI request, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002139 ! liver/biliary system physiology [Term] id: MT:0003253 name: bile duct size namespace: Trait.ontology def: "abnormal distention of the bile ducts due to accumulation of fluid or bile" [MeSH:National Library of Medicine_Medical Subject Headings, ncbi:Matthew Mailman_NCBI request] is_a: MT:0003252 ! bile duct physiology [Term] id: MT:0003254 name: bile duct inflammation namespace: Trait.ontology def: "local accumulation of fluid, plasma proteins, and leukocytes in the bile ducts" [ncbi:Matthew Mailman_NCBI request, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "cholangitis" EXACT [] is_a: MT:0001846 ! tissue specific inflammatory response is_a: MT:0003252 ! bile duct physiology [Term] id: MT:0003255 name: bile duct proliferation namespace: Trait.ontology def: "the appearance of an increased number of bile ducts in the liver; a sign of progressive liver disease" [ncbi:Matthew Mailman_NCBI request] is_a: MT:0003252 ! bile duct physiology [Term] id: MT:0003256 name: biliary cirrhosis namespace: Trait.ontology def: "liver damage to parenchymal cells due to obstruction of bile flow in the bile ducts" [MeSH:National Library of Medicine_Medical Subject Headings, ncbi:Matthew Mailman_NCBI request] is_a: MT:0003252 ! bile duct physiology [Term] id: MT:0003257 name: abdominal wall morphology namespace: Trait.ontology def: "malformation in the margins that enclose the abdominal cavity; the major part is muscular but also includes skin, subcutaneous fat, fascia and the parietal peritoneum" [MeSH:National Library of Medicine_Medical Subject Headings, ncbi:Matthew Mailman_NCBI request] is_a: MT:0003385 ! body wall morphology [Term] id: MT:0003258 name: hiatal hernia namespace: Trait.ontology def: "protrusion of abdominal structures through the esophageal hiatus of the diaphragm" [MeSH:National Library of Medicine_Medical Subject Headings, ncbi:Matthew Mailman_NCBI request, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0003257 ! abdominal wall morphology [Term] id: MT:0003259 name: nausea namespace: Trait.ontology def: "gastric discomfort associated with the inclination to vomit" [ncbi:Matthew Mailman_NCBI request, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001664 ! digestion [Term] id: MT:0003260 name: vomiting namespace: Trait.ontology def: "the retrograde expulsion of gastric contents through the oral cavity" [ncbi:Matthew Mailman_NCBI request, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001664 ! digestion [Term] id: MT:0003261 name: hematemesis namespace: Trait.ontology def: "vomiting of blood; indicative of bleeding in the upper gastrointestinal tract" [MeSH:National Library of Medicine_Medical Subject Headings, ncbi:Matthew Mailman_NCBI request] synonym: "vomiting blood" EXACT [] is_a: MT:0003260 ! vomiting [Term] id: MT:0003262 name: intestinal/bowel diverticulum namespace: Trait.ontology def: "a pouch or sac protruding from the intestinal or bowel wall " [MeSH:National Library of Medicine_Medical Subject Headings, ncbi:Matthew Mailman_NCBI request] is_a: MT:0000477 ! intestine morphology [Term] id: MT:0003263 name: cholesterol biosynthesis namespace: Trait.ontology def: "altered ability to form cholesterol from constituent compounds" [MeSH:National Library of Medicine_Medical Subject Headings, ncbi:Matthew Mailman_NCBI request] is_a: MT:0003191 ! cellular cholesterol metabolism [Term] id: MT:0003266 name: biliary cysts namespace: Trait.ontology def: "the appearance of fluid-filled sacs within the bile ducts" [MeSH:National Library of Medicine_Medical Subject Headings, ncbi:Matthew Mailman_NCBI request] synonym: "choledochal cyst" EXACT [] synonym: "choledochocele" EXACT [] synonym: "common bile duct cyst" EXACT [] is_a: MT:0002928 ! bile duct morphology [Term] id: MT:0003267 name: constipation namespace: Trait.ontology def: "incomplete, infrequent or difficult evacuation of fecal matter " [MeSH:National Library of Medicine_Medical Subject Headings, ncbi:Matthew Mailman_NCBI request] is_a: MT:0003866 ! defecation [Term] id: MT:0003268 name: chronic constipation namespace: Trait.ontology def: "prolonged or long-term difficulty in evacuation of fecal matter " [MeSH:National Library of Medicine_Medical Subject Headings, ncbi:Matthew Mailman_NCBI request] is_a: MT:0003267 ! constipation [Term] id: MT:0003269 name: colonic polyps namespace: Trait.ontology def: "abnormal tissue masses that protrude into the lumen of the colon and are tethered to the wall of the colon" [MeSH:National Library of Medicine_Medical Subject Headings, ncbi:Matthew Mailman_NCBI request] is_a: MT:0000495 ! colon morphology [Term] id: MT:0003270 name: intestinal obstruction namespace: Trait.ontology def: "any impediment, blockage, or reversal of the normal flow of the intestinal contents toward the anus " [MeSH:National Library of Medicine_Medical Subject Headings, ncbi:Matthew Mailman_NCBI request] is_a: MT:0001664 ! digestion [Term] id: MT:0003271 name: duodenum morphology namespace: Trait.ontology def: "malformation in the first division of the small intestine that extends from the pyloris to the junction with the jejunum " [MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0000496 ! small intestine morphology [Term] id: MT:0003272 name: duodenal atresia namespace: Trait.ontology def: "congenital blockage or absence of the lumen of the duodenum" [MeSH:National Library of Medicine_Medical Subject Headings, ncbi:Matthew Mailman_NCBI request] is_a: MT:0003271 ! duodenum morphology [Term] id: MT:0003273 name: duodenal ulcer namespace: Trait.ontology def: "a lesion on the mucosal surface of the duodenum, usually produced by the sloughing of inflammatory necrotic tissue" [MeSH:National Library of Medicine_Medical Subject Headings, ncbi:Matthew Mailman_NCBI request] synonym: "Curling ulcer" EXACT [] is_a: MT:0003271 ! duodenum morphology is_a: MT:0003301 ! peptic ulcer [Term] id: MT:0003274 name: intestinal microaneurysm namespace: Trait.ontology def: "focal dilation of arteriocapillary junctions in the intestine" [ncbi:Matthew Mailman_NCBI request, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000477 ! intestine morphology [Term] id: MT:0003275 name: gastric microaneurysm namespace: Trait.ontology def: "focal dilation of arteriocapillary junctions in the stomach" [ncbi:Matthew Mailman_NCBI request, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000470 ! stomach morphology [Term] id: MT:0003276 name: esophageal atresia namespace: Trait.ontology def: "congenital blockage or absence of the lumen of the esophagus" [MeSH:National Library of Medicine_Medical Subject Headings, ncbi:Matthew Mailman_NCBI request] synonym: "esophageal narrowing" EXACT [] is_a: MT:0000467 ! esophagus morphology [Term] id: MT:0003277 name: esophageal papilloma namespace: Trait.ontology def: "benign epithelial tumor of the esophagus" [ncbi:Matthew Mailman_NCBI request] is_a: MT:0002014 ! papilloma [Term] id: MT:0003278 name: esophageal inflammation namespace: Trait.ontology def: "local accumulation of fluid, plasma proteins and leukocytes in the esophagus" [MeSH:National Library of Medicine_Medical Subject Headings, ncbi:Matthew Mailman_NCBI request] synonym: "esophagitis" EXACT [] synonym: "inflammation of esophagus" EXACT [] is_a: MT:0001663 ! digestive system physiology is_a: MT:0001846 ! tissue specific inflammatory response [Term] id: MT:0003280 name: urinary incontinence namespace: Trait.ontology def: "inability to control the urinary excretory functions" [ncbi:Matthew Mailman_NCBI request] is_a: MT:0001756 ! urination [Term] id: MT:0003281 name: fecal incontinence namespace: Trait.ontology def: "inability to control the anal sphincter resulting in the involuntary passage of feces" [MeSH:National Library of Medicine_Medical Subject Headings, ncbi:Matthew Mailman_NCBI request] is_a: MT:0003866 ! defecation [Term] id: MT:0003282 name: gastric ulcer namespace: Trait.ontology def: "a lesion on the mucosal surface of the stomach, usually produced by the sloughing of inflammatory necrotic tissue" [MeSH:National Library of Medicine_Medical Subject Headings, ncbi:Matthew Mailman_NCBI request] is_a: MT:0000470 ! stomach morphology is_a: MT:0003301 ! peptic ulcer [Term] id: MT:0003283 name: digestive organ placement namespace: Trait.ontology def: "different location or arrangement of any of the alimentary tract organs" [ncbi:Matthew Mailman_NCBI request] is_a: MT:0000462 ! digestive system morphology [Term] id: MT:0003284 name: large intestine placement namespace: Trait.ontology def: "different location or arrangement of the large intestinal tract" [ncbi:Matthew Mailman_NCBI request] is_a: MT:0000489 ! large intestine morphology is_a: MT:0003283 ! digestive organ placement [Term] id: MT:0003286 name: gastroesophageal reflux namespace: Trait.ontology def: "retrograde movement of gastric or duodenal contents into the esophagus" [MeSH:National Library of Medicine_Medical Subject Headings, ncbi:Matthew Mailman_NCBI request] is_a: MT:0001664 ! digestion [Term] id: MT:0003287 name: intestinal hemangioma namespace: Trait.ontology def: "a benign tumor of the intestine, originating from the overgrowth of blood vessels" [MeSH:National Library of Medicine_Medical Subject Headings, ncbi:Matthew Mailman_NCBI request] synonym: "intestinal angioma" EXACT [] is_a: MT:0002947 ! hemangioma [Term] id: MT:0003288 name: intestinal edema namespace: Trait.ontology def: "an accumulation of an excessive amount of serous fluid in the intestine or intestinal cells " [ncbi:Matthew Mailman_NCBI request] is_a: MT:0001663 ! digestive system physiology is_a: MT:0001785 ! edema [Term] id: MT:0003289 name: intestinal peristalsis namespace: Trait.ontology def: "altered intestinal movement characterized by waves of alternate circular contraction and relaxation of the muscular walls of the bowel that move bowel contents forward" [ncbi:Matthew Mailman_NCBI request, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001664 ! digestion [Term] id: MT:0003292 name: melena namespace: Trait.ontology def: "dark colored, foul-smelling feces due to the presence of blood" [ncbi:Matthew Mailman_NCBI request, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "blood in feces" EXACT [] synonym: "melanorhhagia" EXACT [] synonym: "melanorrhea" EXACT [] is_a: MT:0003868 ! feces composition [Term] id: MT:0003293 name: rectal hemorrhage namespace: Trait.ontology def: "bleeding in the rectum" [ncbi:Matthew Mailman_NCBI request] synonym: "rectal bleeding" EXACT [] is_a: MT:0000465 ! gastrointestinal hemorrhage [Term] id: MT:0003294 name: intussusception namespace: Trait.ontology def: "telescoping of the intestine, or the prolapse of one part of the bowel to another; usually results in obstruction" [MeSH:National Library of Medicine_Medical Subject Headings, ncbi:Matthew Mailman_NCBI request] is_a: MT:0000477 ! intestine morphology [Term] id: MT:0003295 name: lymphomesenteric cysts namespace: Trait.ontology def: "cystic mass in the abdominal mesenchyme containing lymph; sometimes becomes calcified" [MeSH:National Library of Medicine_Medical Subject Headings, ncbi:Matthew Mailman_NCBI request] is_a: MT:0000462 ! digestive system morphology [Term] id: MT:0003296 name: microcolon namespace: Trait.ontology def: "small, unused colon in neonates, usually due to atresia or other gastrointestinal blockage" [ncbi:Matthew Mailman_NCBI request, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000495 ! colon morphology [Term] id: MT:0003297 name: fibromatosis namespace: Trait.ontology def: "widespread or multiple benign tumors of fibrous or fully developed connective tissue " [MeSH:National Library of Medicine_Medical Subject Headings, ncbi:Matthew Mailman_NCBI request] synonym: "fibroma" EXACT [] is_a: MT:0002019 ! tumor incidence [Term] id: MT:0003298 name: choking namespace: Trait.ontology def: "spasm of the larynx and trachea due to prevention of respiration by compression or obstruction" [ncbi:Matthew Mailman_NCBI request, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002133 ! respiratory system physiology [Term] id: MT:0003299 name: gastric polyps namespace: Trait.ontology def: "abnormal tissue masses that protrude into the lumen of the stomach and are tethered to the wall of the colon" [MeSH:National Library of Medicine_Medical Subject Headings, ncbi:Matthew Mailman_NCBI request] is_a: MT:0000470 ! stomach morphology [Term] id: MT:0003300 name: gastrointestinal ulcer namespace: Trait.ontology def: "any lesion on the mucosal surface of the gastrointestinal tract, usually produced by the sloughing of inflammatory necrotic tissue" [MeSH:National Library of Medicine_Medical Subject Headings, ncbi:Matthew Mailman_NCBI request] is_a: MT:0000462 ! digestive system morphology [Term] id: MT:0003301 name: peptic ulcer namespace: Trait.ontology def: "any lesion on the mucosal surface of the portion of the alimentary tract that is exposed to gastric acid, usually in the stomach or the duodenum" [MeSH:National Library of Medicine_Medical Subject Headings, ncbi:Matthew Mailman_NCBI request, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "gastroduodenal ulcer" EXACT [] synonym: "marginal ulcer" EXACT [] is_a: MT:0003300 ! gastrointestinal ulcer [Term] id: MT:0003302 name: perirectal abscess namespace: Trait.ontology def: "acute focal inflammation of the tissues surrounding the rectum, often with accumulation of purulent material" [MeSH:National Library of Medicine_Medical Subject Headings, ncbi:Matthew Mailman_NCBI request] is_a: MT:0000492 ! rectum morphology [Term] id: MT:0003303 name: peritoneal inflammation namespace: Trait.ontology def: "local accumulation of fluid, plasma proteins, and leukocytes in the membrane that lines the abdominal cavity and covers most of the viscera" [ncbi:Matthew Mailman_NCBI request, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "peritoneum inflammation" EXACT [] is_a: MT:0001663 ! digestive system physiology is_a: MT:0001846 ! tissue specific inflammatory response [Term] id: MT:0003304 name: large intestinal inflammation namespace: Trait.ontology def: "local accumulation of fluid, plasma proteins, and leukocytes in the large intestine" [MeSH:National Library of Medicine_Medical Subject Headings, ncbi:Matthew Mailman_NCBI request] is_a: MT:0001858 ! intestinal inflammation [Term] id: MT:0003305 name: proctitis namespace: Trait.ontology def: "local accumulation of fluid, plasma proteins, and leukocytes in the mucous membrane of the rectum" [MeSH:National Library of Medicine_Medical Subject Headings, ncbi:Matthew Mailman_NCBI request] is_a: MT:0003304 ! large intestinal inflammation [Term] id: MT:0003306 name: small intestinal inflammation namespace: Trait.ontology def: "local accumulation of fluid, plasma proteins, and leukocytes in the small intestine" [MeSH:National Library of Medicine_Medical Subject Headings, ncbi:Matthew Mailman_NCBI request] is_a: MT:0001858 ! intestinal inflammation [Term] id: MT:0003307 name: pyloric stenosis namespace: Trait.ontology def: "a narrowing of the gastric outlet of the stomach, often due to muscular hypertrophy or scarring from local inflammation" [ncbi:Matthew Mailman_NCBI request, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000470 ! stomach morphology [Term] id: MT:0003308 name: cochlear sensory epithelium morphology namespace: Trait.ontology def: "structure of the epithelial cell layer containing the sensory hair cells and their associated sensory nerve terminals" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] synonym: "cochlear neuroepithelium morphology" EXACT [] synonym: "inner ear neuroepithelium morphology" EXACT [] is_a: MT:0000031 ! cochlea morphology [Term] id: MT:0003309 name: modiolus morphology namespace: Trait.ontology def: "form or internal structure of the central conical bony pillar of the cochlea" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, J:66787] is_a: MT:0000031 ! cochlea morphology [Term] id: MT:0003310 name: modiolus size namespace: Trait.ontology def: "length, width, volume, or area of the central conical bony pillar of the cochlea" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, J:66787] is_a: MT:0003309 ! modiolus morphology [Term] id: MT:0003311 name: urine amino acid level namespace: Trait.ontology def: "excretion of amino acids in the urine, especially in excessive amounts" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, J:66560] synonym: "hyperaminoaciduria" EXACT [] is_a: MT:0001757 ! urine chemistry [Term] id: MT:0003312 name: locomotor coordination namespace: Trait.ontology is_a: MT:0001392 ! locomotor activity [Term] id: MT:0003313 name: locomotor activation namespace: Trait.ontology subset: slim_pig is_a: MT:0001392 ! locomotor activity [Term] id: MT:0003314 name: control of range of motion namespace: Trait.ontology is_a: MT:0001516 ! motor coordination/ balance [Term] id: MT:0003315 name: perineum morphology namespace: Trait.ontology def: "malformation in the area between the genital organs and the anus that lies beneath the pelvic diaphragm" [ncbi:Matthew Mailman_NCBI request, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000462 ! digestive system morphology is_a: MT:0002160 ! reproductive system morphology [Term] id: MT:0003316 name: perineal fistula namespace: Trait.ontology def: "an abnormal anatomical passage that connects the perineum to organs such as the bladder or the rectum " [MeSH:National Library of Medicine_Medical Subject Headings, ncbi:Matthew Mailman_NCBI request] is_a: MT:0003315 ! perineum morphology [Term] id: MT:0003317 name: anoperineal fistula namespace: Trait.ontology def: "an abnormal anatomical passage that connects the perineum to the anus" [MeSH:National Library of Medicine_Medical Subject Headings, ncbi:Matthew Mailman_NCBI request] is_a: MT:0003316 ! perineal fistula is_a: MT:0005034 ! anus morphology [Term] id: MT:0003318 name: rectoperineal fistula namespace: Trait.ontology def: "an abnormal anatomical passage that connects the perineum to the rectum " [MeSH:National Library of Medicine_Medical Subject Headings, ncbi:Matthew Mailman_NCBI request] synonym: "rectoperitoneal fistula" EXACT [] is_a: MT:0000492 ! rectum morphology is_a: MT:0003316 ! perineal fistula [Term] id: MT:0003319 name: anal fistula namespace: Trait.ontology def: "an abnormal anatomical passage at or near the anus that usually opens into the rectum above the internal sphincter" [ncbi:Matthew Mailman_NCBI request, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0005034 ! anus morphology [Term] id: MT:0003320 name: rectovaginal fistula namespace: Trait.ontology def: "an abnormal anatomical passage connecting the rectum and the vagina " [MeSH:National Library of Medicine_Medical Subject Headings, ncbi:Matthew Mailman_NCBI request] is_a: MT:0000492 ! rectum morphology is_a: MT:0001139 ! vagina morphology [Term] id: MT:0003321 name: tracheoesophageal fistula namespace: Trait.ontology def: "an abnormal passage between the esophagus and the trachea, acquired or congenital, often associated with esophageal atresia" [MeSH:National Library of Medicine_Medical Subject Headings, ncbi:Matthew Mailman_NCBI request] synonym: "esophagotracheal fistula" EXACT [] is_a: MT:0000467 ! esophagus morphology is_a: MT:0002282 ! trachea morphology [Term] id: MT:0003322 name: biliary fistula namespace: Trait.ontology def: "an abnormal anatomical passage that connects any organ of the biliary tract and other organs " [MeSH:National Library of Medicine_Medical Subject Headings, ncbi:Matthew Mailman_NCBI request] is_a: MT:0005083 ! biliary tract morphology [Term] id: MT:0003323 name: gastrocolic fistula namespace: Trait.ontology def: "an abnormal anatomical passage between the stomach and the colon" [ncbi:Matthew Mailman_NCBI request, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000470 ! stomach morphology is_a: MT:0000495 ! colon morphology [Term] id: MT:0003324 name: liver adenoma namespace: Trait.ontology def: "benign epithelial neoplasm of the liver" [ncbi:Matthew Mailman_NCBI request, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002815 ! adenoma [Term] id: MT:0003325 name: liver function namespace: Trait.ontology def: "reduced normal function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [MeSH:National Library of Medicine_Medical Subject Headings, ncbi:Matthew Mailman_NCBI request] is_a: MT:0000609 ! liver physiology [Term] id: MT:0003326 name: liver failure namespace: Trait.ontology def: "cessation of function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [MeSH:National Library of Medicine_Medical Subject Headings, ncbi:Matthew Mailman_NCBI request] is_a: MT:0000609 ! liver physiology [Term] id: MT:0003327 name: liver cysts namespace: Trait.ontology def: "abnormal membranous sacs in any portion of the liver" [MeSH:National Library of Medicine_Medical Subject Headings, ncbi:Matthew Mailman_NCBI request] is_a: MT:0000598 ! liver morphology [Term] id: MT:0003328 name: portal blood pressure namespace: Trait.ontology def: "elevation of arterial blood pressure in the hepatic portal system, often a result of cirrhosis or of blockage of the portal vein" [MeSH:National Library of Medicine_Medical Subject Headings, ncbi:Matthew Mailman_NCBI request] is_a: MT:0000609 ! liver physiology [Term] id: MT:0003329 name: amyloid beta deposits namespace: Trait.ontology def: "formation of self-assembled aggregates of the App Abeta protein fragment; often seen in neurodegenerative disorders such as Alzheimer's disease" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] synonym: "amyloid beta plaques" EXACT [] is_a: MT:0003632 ! nervous system morphology [Term] id: MT:0003330 name: auditory tube morphology namespace: Trait.ontology def: "form or structure of the tube connecting the tympanic cavity and the nasopharynx that allows equalization of pressure between the tympanic cavity and the environment" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "Eustachian tube morphology" EXACT [] synonym: "pharyngotympanic tube morphology" EXACT [] is_a: MT:0000049 ! middle ear morphology [Term] id: MT:0003331 name: hepatocellular carcinoma namespace: Trait.ontology alt_id: MT:0005510 def: "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman_NCBI request] synonym: "liver neoplasia" EXACT [] synonym: "liver neoplasm" EXACT [] synonym: "neoplastic liver" EXACT [] is_a: MT:0002019 ! tumor incidence is_a: MT:0002038 ! carcinoma [Term] id: MT:0003332 name: liver abscess namespace: Trait.ontology def: "collection of purulent exudate within the liver as a result of infection by bacteria, protozoa, or other agents " [MeSH:National Library of Medicine_Medical Subject Headings, ncbi:Matthew Mailman_NCBI request] is_a: MT:0000598 ! liver morphology [Term] id: MT:0003333 name: liver fibrosis namespace: Trait.ontology def: "invasion of fibrous connective tissue into the liver, often resulting from inflammation or injury " [MeSH:National Library of Medicine_Medical Subject Headings, ncbi:Matthew Mailman_NCBI request] synonym: "hepatic fibrosis" EXACT [] is_a: MT:0000598 ! liver morphology [Term] id: MT:0003334 name: pancreatic fibrosis namespace: Trait.ontology def: "invasion of fibrous connective tissue into the pancreas, often resulting from inflammation or injury " [MeSH:National Library of Medicine_Medical Subject Headings, ncbi:Matthew Mailman_NCBI request] is_a: MT:0001944 ! pancreas morphology [Term] id: MT:0003336 name: pancreatic cysts namespace: Trait.ontology def: "the appearance of fluid-filled sacs within the pancreas" [ncbi:Matthew Mailman_NCBI request] is_a: MT:0001944 ! pancreas morphology [Term] id: MT:0003338 name: pancreatic lipomatosis namespace: Trait.ontology def: "an accumulation of abnormally localized or tumor-like fat in the pancreas" [MeSH:National Library of Medicine_Medical Subject Headings, ncbi:Matthew Mailman_NCBI request] is_a: MT:0001944 ! pancreas morphology [Term] id: MT:0003339 name: number of pancreatic beta cells namespace: Trait.ontology def: "fewer than normal number of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine_Medical Subject Headings, ncbi:Matthew Mailman_NCBI request] is_a: MT:0005217 ! pancreatic beta cell morphology [Term] id: MT:0003340 name: acute pancreas inflammation namespace: Trait.ontology def: "early and often transient reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into the pancreas; initiated by injury, infection, or local immune response " [MeSH:National Library of Medicine_Medical Subject Headings, ncbi:Matthew Mailman_NCBI request] is_a: MT:0001869 ! pancreas inflammation [Term] id: MT:0003341 name: chronic pancreas inflammation namespace: Trait.ontology def: "persistent inflammatory response in the pancreas, often caused by persistent infection or during an autoimmune response" [MeSH:National Library of Medicine_Medical Subject Headings, ncbi:Matthew Mailman_NCBI request] is_a: MT:0001869 ! pancreas inflammation [Term] id: MT:0003342 name: accessory spleen namespace: Trait.ontology def: "the splenic tissue is divided into equal masses; often related to situs inversus" [ncbi:Matthew Mailman_NCBI request, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "polysplenia" EXACT [] is_a: MT:0000689 ! spleen morphology [Term] id: MT:0003343 name: fibroadenoma namespace: Trait.ontology def: "a benign epithelial neoplasm containing fibrous tissue" [MeSH:National Library of Medicine_Medical Subject Headings, ncbi:Matthew Mailman_NCBI request] is_a: MT:0002815 ! adenoma [Term] id: MT:0003345 name: number of ribs namespace: Trait.ontology def: "fewer than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine_Medical Subject Headings, ncbi:Matthew Mailman_NCBI request] is_a: MT:0000150 ! rib morphology [Term] id: MT:0003346 name: pectoral muscle morphology namespace: Trait.ontology def: "anomaly in the two muscles that make up the upper and fore part of the chest that adduct and rotate the arm and lift the ribs" [MeSH:National Library of Medicine_Medical Subject Headings, ncbi:Matthew Mailman_NCBI request, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] subset: slim_chkn is_a: MT:0000759 ! skeletal muscle morphology [Term] id: MT:0003349 name: circulating renin level namespace: Trait.ontology def: "aberrant blood concentration of this enzyme which is secreted by the kidney; it cleaves a bond in angiotensionogen to generate angiotensin I " [MeSH:National Library of Medicine_Medical Subject Headings, ncbi:Matthew Mailman_NCBI request] is_a: MT:0000179 ! blood chemistry is_a: MT:0005319 ! enzyme/ coenzyme level [Term] id: MT:0003351 name: circulating levels of thyroid hormone namespace: Trait.ontology def: "reduced concentration of hormones in the blood that are synthesized and secreted by the thyroid" [ncbi:Matthew Mailman_NCBI request] is_a: MT:0005418 ! circulating hormone level is_a: MT:0005468 ! thyroid hormone level [Term] id: MT:0003354 name: astrocytosis namespace: Trait.ontology def: "a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0002183 ! gliosis [Term] id: MT:0003356 name: luteinization namespace: Trait.ontology def: "atypical transformation of the mature ovarian follicle and its theca interna into a corpus luteum after ovulation" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, J:43075, J:57854] subset: slim_pig is_a: MT:0001126 ! ovary morphology [Term] id: MT:0003357 name: granulosa cell differentiation namespace: Trait.ontology def: "atypical differentiation of the layer of small cells that forms the wall of an ovarian follicle" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, J:43075] is_a: MT:0001131 ! ovarian follicle morphology [Term] id: MT:0003358 name: hypaxial muscle morphology namespace: Trait.ontology def: "malformation of the muscles derived from the lateral myotome and lateral portion of the dermomyotome; these include the thoracic intercostal and abdominal muscles, limb muscles and superficial back muscles, as well as the diaphragm and the tip of the tongue" [PMID:1591996] subset: slim_cattle subset: slim_chkn subset: slim_pig synonym: "abnormal limb muscle morphology" EXACT [] is_a: MT:0000759 ! skeletal muscle morphology [Term] id: MT:0003359 name: hypaxial muscle cell number namespace: Trait.ontology def: "reduced cell number in the thoracic intercostal and abdominal muscles, limb muscles and superficial back muscles, as well as the diaphragm and the tip of the tongue" [PMID:1591996] is_a: MT:0003358 ! hypaxial muscle morphology [Term] id: MT:0003361 name: circulating gonadotropin level namespace: Trait.ontology def: "aberrant blood concentration of the peptide hormones that stimulate gonadal functions such as gametogenesis and sex steroid hormone production in the ovary and the testis" [MeSH:National Library of Medicine_Medical Subject Headings] subset: slim_cattle subset: slim_chkn subset: slim_pig is_a: MT:0005418 ! circulating hormone level [Term] id: MT:0003364 name: insulinoma namespace: Trait.ontology def: "a pancreatic islet beta cell adenoma that secretes excess insulin" [ncbi:Matthew Mailman_NCBI request, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "beta-cell adenoma" EXACT [] synonym: "beta-cell tumor" EXACT [] synonym: "insuloma" EXACT [] is_a: MT:0003430 ! islet cell adenoma [Term] id: MT:0003365 name: glucagonoma namespace: Trait.ontology def: "a pancreatic islet alpha cell adenoma that secretes excess glucagon" [MeSH:National Library of Medicine_Medical Subject Headings, ncbi:Matthew Mailman_NCBI request] synonym: "alpha-cell adenoma" EXACT [] synonym: "alpha-cell tumor" EXACT [] is_a: MT:0003430 ! islet cell adenoma [Term] id: MT:0003366 name: circulating glucocorticoid level namespace: Trait.ontology def: "aberrant blood concentration of the corticosteroids regulating carbohydrate metabolism and exhibiting anti-inflammatory activity" [ncbi:Matthew Mailman_NCBI request, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] subset: slim_chkn subset: slim_pig is_a: MT:0005418 ! circulating hormone level [Term] id: MT:0003369 name: circulating estrogen level namespace: Trait.ontology def: "aberration in the blood concentration of any substance that causes development of the female reproductive organs and secondary sexual characteristics" [ncbi:Matthew Mailman_NCBI request, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0005418 ! circulating hormone level [Term] id: MT:0003372 name: circulating mineralcorticoid level namespace: Trait.ontology def: "aberrant blood concentration of corticosteroids that influence water and electrolyte metabolism and balance " [ncbi:Matthew Mailman_NCBI request, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal circulating mineralocorticoid level" EXACT [] is_a: MT:0005418 ! circulating hormone level [Term] id: MT:0003375 name: menstrual cycle (sensu H. sapiens) namespace: Trait.ontology def: "a recurring cycle in human primates in which the endometrial lining of the uterus prepares for pregnancy and ovulation occurs; if pregnancy does not occur the lining is discharged at menstruation" [ncbi:Matthew Mailman_NCBI request] is_a: MT:0003699 ! female reproductive system physiology [Term] id: MT:0003376 name: amenorrhea (sensu H. sapiens) namespace: Trait.ontology def: "absence or abnormal cessation of the shedding of the endometrium and associated bleeding in primates" [MeSH:National Library of Medicine_Medical Subject Headings, ncbi:Matthew Mailman_NCBI request] synonym: "absent menstruation" EXACT [] is_a: MT:0003375 ! menstrual cycle (sensu H. sapiens) [Term] id: MT:0003377 name: onset of menarche namespace: Trait.ontology def: "the onset of menstrual cycles occurs at a later age than normal" [MeSH:National Library of Medicine_Medical Subject Headings, ncbi:Matthew Mailman_NCBI request] is_a: MT:0001938 ! time of sexual maturation [Term] id: MT:0003380 name: intestine regeneration namespace: Trait.ontology def: "deviation from the normal ability of the intestine to regenerate healthy tissue following injury" [J:93428, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0001663 ! digestive system physiology [Term] id: MT:0003381 name: vitreal fibroplasia namespace: Trait.ontology def: "production of excess fibrous tissue in the vitreous body of the eye" [brs:Beverly Richards-Smith_Mouse Genome Informatics Curator] is_a: MT:0002699 ! vitreous body [Term] id: MT:0003382 name: tail position namespace: Trait.ontology is_a: MT:0001391 ! tail movements [Term] id: MT:0003383 name: gluconeogenesis namespace: Trait.ontology def: "anomaly in the formation of glucose from non-carbohydrates, such as proteins or fat" [J:93896] is_a: MT:0002078 ! glucose homeostasis [Term] id: MT:0003384 name: ventral body wall morphology namespace: Trait.ontology def: "malformation in the anterior portion of a human body or the lower surface of an animal body comprised of ectoderm and mesoderm layers that encloses the body cavity" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, monikat:Monika Tomczuk_Mouse Genome Informatics Curator] synonym: "ventral body wall defects" EXACT [] is_a: MT:0003385 ! body wall morphology [Term] id: MT:0003385 name: body wall morphology namespace: Trait.ontology def: "malformation in the external portion of an animal body comprised of ectoderm and mesoderm layers that encloses the body cavity " [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0002085 ! embryonic tissue morphology [Term] id: MT:0003387 name: aorta patency namespace: Trait.ontology def: "any measurable characteristic pertaining to the openness of the main trunk of the systemic arteries" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] synonym: "aortic patency" RELATED [] relationship: part_of MT:0007044 ! aorta integrity [Term] id: MT:0003390 name: lymphedema namespace: Trait.ontology def: "abnormal swelling in the soft tissues of the limbs, or less often the trunk, caused by the buildup of lymph fluid" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0001785 ! edema [Term] id: MT:0003391 name: myxoma namespace: Trait.ontology def: "a benign tumor composed of connective tissue embedded in mucus" [smb:Susan M. Bello_Mouse Genome Informatics Curator, Taber's Cyclopedic Medical Dictionary_19th edition:ISBN N 0-8036-0655-99] is_a: MT:0002019 ! tumor incidence [Term] id: MT:0003392 name: atrial myxoma namespace: Trait.ontology def: "a primary intracardiac tumor occurring in either the left or right atrium" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0003391 ! myxoma [Term] id: MT:0003395 name: subclavian artery integrity namespace: Trait.ontology def: "any measurable characteristic pertaining to the the structural completeness or structural soundness of the subclavaian arteries; the right subclavian artery extends from the brachiocephalic artery to the right side of the body, the left subclavian artery extends from the aortic arch to the left side of the body." [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] is_a: MT:0003410 ! artery integrity [Term] id: MT:0003396 name: embryonic hematopoiesis namespace: Trait.ontology def: "anomaly in the development of primarily large, nucleated erythroblasts as well as some megakaryocytes and primitive macrophages occurring in blood islands in the yolk sac, generally occurs from E7-E11 in the mouse and through 10 weeks in humans" [J:94136, smb:Susan M. Bello_Mouse Genome Informatics Curator] synonym: "abnormal primitive erythropoiesis" EXACT [] synonym: "abnormal primitive hematopoiesis" EXACT [] is_a: MT:0002086 ! extraembryonic tissue morphology is_a: MT:0002429 ! blood cell morphology/development [Term] id: MT:0003398 name: skeletal muscle size namespace: Trait.ontology def: "greater than average dimensions of one or more of the muscles of the skeleton" [J:94134, smb:Susan M. Bello_Mouse Genome Informatics Curator] subset: slim_cattle subset: slim_chkn subset: slim_pig is_a: MT:0000759 ! skeletal muscle morphology [Term] id: MT:0003399 name: skeletal muscle fiber size namespace: Trait.ontology def: "increase in the size of the large multinucleated cells that make up the skeletal muscles" [J:94134, smb:Susan M. Bello_Mouse Genome Informatics Curator] subset: slim_pig is_a: MT:0003084 ! skeletal muscle fiber morphology [Term] id: MT:0003400 name: kinked neural tube namespace: Trait.ontology def: "twists or kinks in the embryonic neural tube" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, J:66514] is_a: MT:0002151 ! neural tube morphology/development [Term] id: MT:0003401 name: tail bud size namespace: Trait.ontology def: "increased size or area of the primordial region of the embryo that arises to form the tail of the adult" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0002861 ! tail bud morphology [Term] id: MT:0003402 name: liver weight namespace: Trait.ontology def: "reduced average weight of the bile-secreting exocrine gland" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] subset: slim_chkn subset: slim_pig is_a: MT:0000598 ! liver morphology [Term] id: MT:0003405 name: platelet shape namespace: Trait.ontology def: "change in the normal small, disk-like shape of blood plasma cells derived from megakaryocytes and which function to promote blood clotting" [MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0000228 ! thrombopoiesis [Term] id: MT:0003407 name: CNS regeneration namespace: Trait.ontology def: "changes in the ability or inability of healthy central nervous system tissue to regenerate following injury or disease" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0003633 ! nervous system physiology [Term] id: MT:0003409 name: hypertrophic chondrocyte zone width namespace: Trait.ontology def: "decreased width of cartilage cell matrix layer " [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000165 ! hypertrophic chondrocyte zone morphology [Term] id: MT:0003410 name: artery integrity namespace: Trait.ontology def: "any measurable characteristic pertaining to the the structural completeness or structural soundness of the blood vessels that carry blood away from the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] synonym: "arterial integrity" RELATED [] is_a: MT:0000088 ! blood vessel integrity relationship: part_of MT:0002191 ! artery morphology [Term] id: MT:0003412 name: afterhyperpolarization namespace: Trait.ontology def: "anomaly in the currents that follow an action potential and influence firing frequency and neuronal integration" [J:94941, smb:Susan M. Bello_Mouse Genome Informatics Curator] synonym: "abnormal AHP" EXACT [] is_a: MT:0002272 ! nervous system electrophysiology [Term] id: MT:0003413 name: hair follicle integrity namespace: Trait.ontology def: "a retrogressive impairment of function or destruction of the hair follicle" [J:94517, monikat:Monika Tomczuk_Mouse Genome Informatics Curator] is_a: MT:0000375 ! hair follicle structure [Term] id: MT:0003414 name: epidermal cyst namespace: Trait.ontology def: "a cyst formed of a mass of epidermal cells which is present beneath the epidermis; the wall is lined with stratified squamous epithelium and exhibits increased/abnormal keratinization" [MeSH:National Library of Medicine_Medical Subject Headings, monikat:Monika Tomczuk_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001191 ! skin condition [Term] id: MT:0003415 name: priapism namespace: Trait.ontology def: "prolonged penile erection, often painful and without sexual desire" [MeSH:National Library of Medicine_Medical Subject Headings, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0001379 ! penile erection function [Term] id: MT:0003419 name: onset of endochondral bone ossification namespace: Trait.ontology def: "late onset of bone formation in bones that form from cartilage" [J:94631, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0000060 ! onset of bone ossification [Term] id: MT:0003420 name: onset of intramembranous bone ossification namespace: Trait.ontology def: "late onset of bone formation in bones that form without a cartilaginous intermediate including the cranium and clavicle" [J:94631, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0000060 ! onset of bone ossification [Term] id: MT:0003421 name: thyroid gland development namespace: Trait.ontology def: "failure or abnormality in the formation of the thyroid gland during organogenesis" [J:95017, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0000681 ! thyroid gland morphology [Term] id: MT:0003422 name: thrombolysis namespace: Trait.ontology def: "altered ability to break up (lyse) blood clots that are restricting the blood flow" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, J:17427] is_a: MT:0002551 ! blood coagulation [Term] id: MT:0003424 name: neuronal precursor differentiation namespace: Trait.ontology def: "earlier than normal transformation of neuronal precursor cells into neurons" [J:94391, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0006008 ! neurogenesis [Term] id: MT:0003425 name: optic vesicle formation namespace: Trait.ontology def: "anomalous formation of the hollow outgrowth from the lateral aspects of the embryonic forebrain from which the retina and optic nerve develop" [J:94391, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0001286 ! eye development [Term] id: MT:0003426 name: pulmonary interstitial fibrosis namespace: Trait.ontology def: "formation of fibrous tissue within the interstices of the lung as a result of repair or a reactive process" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, J:63134] is_a: MT:0002276 ! lung interstitium morphology is_a: MT:0006050 ! pulmonary fibrosis [Term] id: MT:0003427 name: parakeratosis namespace: Trait.ontology def: "abnormal retention of the nuclei of the keratinocytes in the stratum corneum of the epidermis" [smb:Susan M. Bello_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001240 ! cornified layer morphology [Term] id: MT:0003429 name: response to growth hormone namespace: Trait.ontology def: "no growth response to exogenous growth hormone" [ncbi:Matthew Mailman_NCBI request] is_a: MT:0003638 ! response/metabolism to endogenous compounds [Term] id: MT:0003430 name: islet cell adenoma namespace: Trait.ontology def: "a benign epithelial neoplasm with a glandular organization present in islet cells of the pancreas" [ncbi:Matthew Mailman_NCBI request] is_a: MT:0002815 ! adenoma [Term] id: MT:0003431 name: parathyroid gland physiology namespace: Trait.ontology def: "anomalous function of this paired endocrine gland that normally produces parathyroid hormone (PTH) that regulates calcium and phosphorous metabolism" [ncbi:Matthew Mailman_NCBI request] is_a: MT:0002164 ! gland physiology [Term] id: MT:0003435 name: herniated seminal glands namespace: Trait.ontology def: "protrusion of the seminal vesicles through the pelvic outlet" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, J:73613] synonym: "herniated seminal vesicles" EXACT [] is_a: MT:0002059 ! seminal gland morphology [Term] id: MT:0003436 name: resistance to induced arthritis namespace: Trait.ontology def: "less likely to be stricken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, J:75303] is_a: MT:0002993 ! arthritis [Term] id: MT:0003437 name: carotid body morphology namespace: Trait.ontology def: "any malformation in a small epithelioid structure consisting of a small cluster of chemoreceptive and supporting cells located near the bifurcation of the common carotid artery that serves as a chemoreceptive organ that senses the pH, carbon dioxide, and oxygen concentrations in the blood and plays a crucial role in their homeostatic control" [MeSH:National Library of Medicine_Medical Subject Headings, monikat:Monika Tomczuk_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001001 ! chemoreceptor morphology [Term] id: MT:0003438 name: carotid body activity namespace: Trait.ontology def: "function of a small epithelioid structure consisting of a small cluster of chemoreceptive and supporting cells located near the bifurcation of the common carotid artery that serves as a chemoreceptive organ that senses the pH, carbon dioxide, and oxygen concentrations in the blood and plays a crucial role in their homeostatic control" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] is_a: MT:0001544 ! cardiovascular system physiology [Term] id: MT:0003439 name: glycerol level namespace: Trait.ontology def: "anomalous concentration of this molecule, the backbone of lipids, which is important for gluconeogenesis during starvation" [J:95278, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0001547 ! lipid level [Term] id: MT:0003442 name: circulating glycerol level namespace: Trait.ontology def: "lower than normal concentration of glycerol in the blood" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0003439 ! glycerol level is_a: MT:0003949 ! circulating lipid level [Term] id: MT:0003444 name: neurotransmitter uptake namespace: Trait.ontology def: "aberration in the reabsorbtion of endogenous signaling molecules normally taken in by neurons that alter the behavior of neurons or effector cells" [J:95639, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0002204 ! neurotransmitter level [Term] id: MT:0003445 name: sirenomelia namespace: Trait.ontology def: "fusion of the posterior limbs often with partial or complete fusion of the autopods" [J:67375] is_a: MT:0005221 ! rostral-caudal axis patterning [Term] id: MT:0003446 name: kidney cell number namespace: Trait.ontology def: "decreased cell number in the kidney leading to reduced size" [llw2:Linda Washburn_Mouse Genome Informatics Curator] synonym: "hypoplastic kidney" EXACT [] synonym: "kidney hypoplasia" EXACT [] is_a: MT:0002706 ! kidney size [Term] id: MT:0003448 name: tumor morphology namespace: Trait.ontology def: "changes in the expected pathology for a given tumor type compared to controls" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] synonym: "abnormal tumor morphology" EXACT [] synonym: "altered tumor characteristics" EXACT [] is_a: MT:0002166 ! tumor susceptibility [Term] id: MT:0003449 name: intestinal goblet cell morphology namespace: Trait.ontology def: "malformation of the unicellular mucin-secreting glands" [J:95282, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0000511 ! intestinal mucosa morphology [Term] id: MT:0003450 name: pancreas size namespace: Trait.ontology def: "increase of the size of the pancreas compared to controls" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0001944 ! pancreas morphology [Term] id: MT:0003452 name: parotid gland morphology namespace: Trait.ontology def: "malformation of either of the largest of the major salivary glands situated below and in front of each ear and opening into the parotid duct" [J:94478, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0003792 ! major salivary gland morphology [Term] id: MT:0003453 name: keratinocyte physiology namespace: Trait.ontology def: "atypical function of the cells of the epidermis that produce keratin" [J:94860, monikat:Monika Tomczuk_Mouse Genome Informatics Curator] is_a: MT:0005501 ! skin physiology [Term] id: MT:0003454 name: erythroderma namespace: Trait.ontology def: "exfoliation and widespread, intense reddening of the skin due to inflammatory skin disease" [J:95549, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0001194 ! dermatitis [Term] id: MT:0003455 name: resistance to induced retinal damage namespace: Trait.ontology def: "reduced or absent pathological changes in the retina due to chemical or mechanical agents" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, J:93533] is_a: MT:0001325 ! retina morphology [Term] id: MT:0003456 name: tail size namespace: Trait.ontology alt_id: MT:0005080 def: "length, width or volume of the appendage at the caudal end of the vertebral column " [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] synonym: "tail less" EXACT [] synonym: "tailless" EXACT [] is_a: MT:0002111 ! tail morphology [Term] id: MT:0003457 name: circulating ketone body level namespace: Trait.ontology def: "aberrant amount of acetoacetate, 3-hydroxybutyrate and acteone in the blood; produced by fatty acid and carbohydrate metabolism and seen in conditions such as starvation and diabetes mellitus" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0003949 ! circulating lipid level [Term] id: MT:0003461 name: response to novel object namespace: Trait.ontology is_a: MT:0003107 ! response to novelty [Term] id: MT:0003462 name: response to novel odor namespace: Trait.ontology is_a: MT:0003107 ! response to novelty [Term] id: MT:0003463 name: single cell response namespace: Trait.ontology def: "altered values from controls obtained upon extra- or intracellular recordings from single cells" [Nmice:Neuromice Consortium Submission] is_a: MT:0002272 ! nervous system electrophysiology [Term] id: MT:0003464 name: single cell response threshold namespace: Trait.ontology def: "any change in the value at which a stimulus first elicits a recordable response recorded in a single cell" [Nmice:Neuromice Consortium Submission] is_a: MT:0003463 ! single cell response [Term] id: MT:0003467 name: single cell response intensity namespace: Trait.ontology def: "any change in the value for changes in the degree of de- or hyperpolarization or number of action potentials in response to a specific stimulus recorded in a single cell" [Nmice:Neuromice Consortium Submission] is_a: MT:0003463 ! single cell response [Term] id: MT:0003470 name: summary potential namespace: Trait.ontology def: "anomaly in the electrophysiological recording of the activity of several cells" [Nmice:Neuromice Consortium Submission] is_a: MT:0002272 ! nervous system electrophysiology [Term] id: MT:0003471 name: summary potential threshold namespace: Trait.ontology def: "any change in the value at which a stimulus first elicits a recordable response recorded in several cells or a tissue slice" [Nmice:Neuromice Consortium Submission] is_a: MT:0003470 ! summary potential [Term] id: MT:0003474 name: summary potential intensity namespace: Trait.ontology def: "any change in the value for changes in the degree of de- or hyperpolarization or number of action potentials in response to a specific stimulus recorded in several cells or a tissue slice" [Nmice:Neuromice Consortium Submission] is_a: MT:0003470 ! summary potential [Term] id: MT:0003477 name: nerve fiber response namespace: Trait.ontology def: "anomaly in the electrophysiological recordings from a single or several nerve fiber(s)" [Nmice:Neuromice Consortium Submission] is_a: MT:0002272 ! nervous system electrophysiology [Term] id: MT:0003478 name: nerve fiber response threshold namespace: Trait.ontology def: "any change in the value at which a stimulus first elicits a recordable response recorded in a single or several nerve fiber(s)" [Nmice:Neuromice Consortium Submission] is_a: MT:0003477 ! nerve fiber response [Term] id: MT:0003479 name: nerve fiber response intensity namespace: Trait.ontology def: "any change in the value for changes in the degree of de- or hyperpolarization or number of action potentials in response to a specific stimulus recorded in a single or several nerve fiber(s)" [Nmice:Neuromice Consortium Submission] is_a: MT:0003477 ! nerve fiber response [Term] id: MT:0003484 name: channel response namespace: Trait.ontology alt_id: MT:0002203 def: "anomalies in the electrophysiological recordings from ion channels" [Nmice:Neuromice Consortium Submission] synonym: "channel defects" EXACT [] is_a: MT:0002272 ! nervous system electrophysiology is_a: MT:0003635 ! synaptic transmission [Term] id: MT:0003485 name: channel response threshold namespace: Trait.ontology def: "any change in the value at which a stimulus first elicits a recordable response recorded from ion channels" [Nmice:Neuromice Consortium Submission] is_a: MT:0003484 ! channel response [Term] id: MT:0003486 name: channel response intensity namespace: Trait.ontology def: "any change in the value for changes in the degree of de- or hyperpolarization or number of action potentials in response to a specific stimulus recorded from ion channels" [Nmice:Neuromice Consortium Submission] is_a: MT:0003484 ! channel response [Term] id: MT:0003491 name: voluntary movement namespace: Trait.ontology subset: slim_pig is_a: MT:0002066 ! motor capabilities/coordination/movement [Term] id: MT:0003492 name: involuntary movement namespace: Trait.ontology is_a: MT:0002066 ! motor capabilities/coordination/movement [Term] id: MT:0003495 name: parathyroid adenoma namespace: Trait.ontology def: "appearance of benign neoplasms in the parathyroid gland" [ncbi:Matthew Mailman_NCBI request] is_a: MT:0002815 ! adenoma [Term] id: MT:0003496 name: thyroid adenoma namespace: Trait.ontology def: "appearance of benign neoplasms in the thyroid gland" [ncbi:Matthew Mailman_NCBI request] is_a: MT:0002815 ! adenoma [Term] id: MT:0003497 name: response to parathyroid hormone namespace: Trait.ontology def: "no changes in calcium homeostasis in response to endogenous or exogenous hormone" [ncbi:Matthew Mailman_NCBI request] is_a: MT:0003638 ! response/metabolism to endogenous compounds [Term] id: MT:0003498 name: thyroid gland cell number namespace: Trait.ontology def: "increased size due to increased cell number of the endocrine gland located in the front and to the sides of the upper part of the trachea and which secretes thyroid hormone and calcitonin" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, ncbi:Matthew Mailman_NCBI request, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0005355 ! thyroid gland size [Term] id: MT:0003501 name: iodide oxidation namespace: Trait.ontology def: "thyroid defect in oxidation and organification of iodide" [ncbi:Matthew Mailman_NCBI request] is_a: MT:0002876 ! thyroid physiology [Term] id: MT:0003504 name: thyroid inflammation namespace: Trait.ontology def: "local accumulation of fluid, plasma proteins, and leukocytes in the thyroid gland" [ncbi:Matthew Mailman_NCBI request] is_a: MT:0001846 ! tissue specific inflammatory response is_a: MT:0002876 ! thyroid physiology [Term] id: MT:0003505 name: prolactinoma namespace: Trait.ontology def: "a pituitary adenoma characterized by secretion of prolactin" [MeSH:National Library of Medicine_Medical Subject Headings, ncbi:Matthew Mailman_NCBI request] is_a: MT:0002041 ! pituitary adenoma [Term] id: MT:0003506 name: growth hormone secretion namespace: Trait.ontology def: "excessive secretion of growth hormone resulting in progressive enlargement of the face, hands, feet, head, and thorax; organomegaly and impaired glucose homeostasis may ensue" [MeSH:National Library of Medicine_Medical Subject Headings, ncbi:Matthew Mailman_NCBI request, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "increased growth hormone secretion" EXACT [] is_a: MT:0001746 ! pituitary secretion [Term] id: MT:0003507 name: ovary physiology namespace: Trait.ontology def: "anomaly or loss either the production of female germ cells or the endocrine cells for the production of estrogen and progesterone" [MeSH:National Library of Medicine_Medical Subject Headings, ncbi:Matthew Mailman_NCBI request] is_a: MT:0005647 ! sex gland physiology [Term] id: MT:0003508 name: circulating levels of dihydrotestosterone namespace: Trait.ontology def: "aberration in the blood concentration of this potent androgenic metabolite of testosterone" [MeSH:National Library of Medicine_Medical Subject Headings, ncbi:Matthew Mailman_NCBI request] synonym: "abnormal circulating level of stanolone" EXACT [] is_a: MT:0005418 ! circulating hormone level [Term] id: MT:0003511 name: labium morphology namespace: Trait.ontology def: "malformation of the folds of skin which form the inner lips (labia minora) and outer lips (labia majora) on both sides of the vaginal opening " [ncbi:Matthew Mailman_NCBI request] is_a: MT:0003126 ! vulva morphology [Term] id: MT:0003512 name: labia size namespace: Trait.ontology def: "increased size of the folds of skin which form the inner lips (labia minora) and outer lips (labia majora) on both sides of the vaginal opening " [ncbi:Matthew Mailman_NCBI request] is_a: MT:0003511 ! labium morphology [Term] id: MT:0003514 name: interlabial sulcus namespace: Trait.ontology def: "the presence of grooves or furrows in the folds of skin which lips on both sides of the vaginal opening " [ncbi:Matthew Mailman_NCBI request, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0003511 ! labium morphology [Term] id: MT:0003515 name: labia majora morphology namespace: Trait.ontology def: "malformation of the folds of skin which form the outer lips (labia majora) on both sides of the vaginal opening " [ncbi:Matthew Mailman_NCBI request] is_a: MT:0003511 ! labium morphology [Term] id: MT:0003517 name: labia majora size namespace: Trait.ontology def: "increased size of the folds of skin which form the outer lips (labia majora) on both sides of the vaginal opening" [ncbi:Matthew Mailman_NCBI request] is_a: MT:0003512 ! labia size is_a: MT:0003515 ! labia majora morphology [Term] id: MT:0003519 name: labia majora shape namespace: Trait.ontology def: "appearance of the folds of skin which form the outer lips (labia majora) on both sides of the vaginal opening" [ncbi:Matthew Mailman_NCBI request] is_a: MT:0003515 ! labia majora morphology [Term] id: MT:0003520 name: labia minora morphology namespace: Trait.ontology def: "malformation of the folds of skin which form the inner lips (labia minora) on both sides of the vaginal opening " [ncbi:Matthew Mailman_NCBI request] is_a: MT:0003511 ! labium morphology [Term] id: MT:0003522 name: labia minora size namespace: Trait.ontology def: "increased size of the folds of skin which form the inner lips (labia minora) on both sides of the vaginal opening " [ncbi:Matthew Mailman_NCBI request] is_a: MT:0003512 ! labia size is_a: MT:0003520 ! labia minora morphology [Term] id: MT:0003524 name: labia minora shape namespace: Trait.ontology def: "appearance of the folds of skin which form the inner lips (labia minora) on both sides of the vaginal opening " [ncbi:Matthew Mailman_NCBI request] is_a: MT:0003520 ! labia minora morphology [Term] id: MT:0003525 name: vulval warts namespace: Trait.ontology def: "benign epithelial growths of the external genitalia of the female" [ncbi:Matthew Mailman_NCBI request] is_a: MT:0003126 ! vulva morphology [Term] id: MT:0003526 name: vulval cysts namespace: Trait.ontology def: "cystic vulva; usually refers to a benign growth" [MeSH:National Library of Medicine_Medical Subject Headings, ncbi:Matthew Mailman_NCBI request] is_a: MT:0003126 ! vulva morphology [Term] id: MT:0003528 name: vulva size namespace: Trait.ontology def: "increased size of the external genitalia of the female" [ncbi:Matthew Mailman_NCBI request, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0003126 ! vulva morphology [Term] id: MT:0003529 name: clitoris size namespace: Trait.ontology def: "increased size of the small, erectile body located at the anterior end of the vulva" [ncbi:Matthew Mailman_NCBI request, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0003127 ! clitoris morphology [Term] id: MT:0003531 name: vagina development namespace: Trait.ontology def: "abnormal morphogenesis of the female reproductive canal located between the uterus and the vulva" [ncbi:Matthew Mailman_NCBI request] is_a: MT:0001139 ! vagina morphology is_a: MT:0003936 ! reproductive system development [Term] id: MT:0003532 name: rudimentary vagina namespace: Trait.ontology def: "not fully developed or remnant of the female reproductive canal located between the uterus and the vulva" [ncbi:Matthew Mailman_NCBI request] is_a: MT:0003531 ! vagina development [Term] id: MT:0003533 name: bifid vagina namespace: Trait.ontology def: "cleft of the female reproductive canal located between the uterus and the vulva into two parts or branches" [ncbi:Matthew Mailman_NCBI request, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "double vagina" EXACT [] is_a: MT:0003531 ! vagina development [Term] id: MT:0003534 name: blind vagina namespace: Trait.ontology def: "presence the female reproductive canal that ends in a sac and does not connect to internal genitalia" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, ncbi:Matthew Mailman_NCBI request] comment: this is our best guess at the definition of this term based on other similar terms--csmith is_a: MT:0003531 ! vagina development [Term] id: MT:0003536 name: vaginal dryness namespace: Trait.ontology def: "lack of the normal presence or reduced presence of secretions in the vagina" [ncbi:Matthew Mailman_NCBI request] is_a: MT:0001139 ! vagina morphology [Term] id: MT:0003537 name: hydrometrocolops namespace: Trait.ontology def: "collection of fluid in the vagina; often due to a congenital obstruction" [ncbi:Matthew Mailman_NCBI request] is_a: MT:0001139 ! vagina morphology [Term] id: MT:0003538 name: hymen development namespace: Trait.ontology def: "anomaly in the morphogenesis of the thin membrane which may partially occlude the opening of the vagina; often absent in normal females" [ncbi:Matthew Mailman_NCBI request, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001142 ! vaginal opening [Term] id: MT:0003541 name: vaginal inflammation namespace: Trait.ontology def: "local accumulation of fluid, plasma proteins, and leukocytes in the vagina" [ncbi:Matthew Mailman_NCBI request] synonym: "vaginitis" EXACT [] is_a: MT:0001139 ! vagina morphology is_a: MT:0001846 ! tissue specific inflammatory response [Term] id: MT:0003547 name: pulmonary pressure namespace: Trait.ontology def: "tension of the blood within the pulmonary arteries" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] is_a: MT:0002295 ! pulmonary circulation [Term] id: MT:0003550 name: short perineum namespace: Trait.ontology def: "reduced length of the area between the genital organs and the anus that lies beneath the pelvic diaphragm" [ncbi:Matthew Mailman_NCBI request] is_a: MT:0005189 ! anogenital distance [Term] id: MT:0003551 name: blind perineal pouch namespace: Trait.ontology def: "opening in the perineum leading to a blind-ending sac " [ncbi:Matthew Mailman_NCBI request] is_a: MT:0003315 ! perineum morphology [Term] id: MT:0003552 name: vaginal cysts namespace: Trait.ontology def: "benign epithelial growths of the female reproductive canal located between the uterus and the vulva" [ncbi:Matthew Mailman_NCBI request] is_a: MT:0001139 ! vagina morphology [Term] id: MT:0003553 name: foreskin morphology namespace: Trait.ontology def: "anomaly of the loose fold of skin that covers the penis" [ncbi:Matthew Mailman_NCBI request] synonym: "abnormal prepuce" EXACT [] is_a: MT:0005187 ! penis morphology [Term] id: MT:0003554 name: phimosis namespace: Trait.ontology def: "narrow opening of the foreskin resulting in the inability to retract the foreskin over the glans penis " [MeSH:National Library of Medicine_Medical Subject Headings, ncbi:Matthew Mailman_NCBI request] is_a: MT:0003553 ! foreskin morphology [Term] id: MT:0003555 name: chordee namespace: Trait.ontology def: "acute angulation of the penis upon erection; often painful and due to disease or congenital malformation" [ncbi:Matthew Mailman_NCBI request, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0003698 ! male reproductive system physiology [Term] id: MT:0003559 name: bifid uterus namespace: Trait.ontology def: "cleft of the female muscular organ of gestation into two parts or branches, often having the appearance of two lobes" [ncbi:Matthew Mailman_NCBI request] is_a: MT:0001120 ! uterus morphology [Term] id: MT:0003560 name: osteoarthritis namespace: Trait.ontology def: "a type of arthritis that is caused by the breakdown and eventual loss of the cartilage of one or more joints" [J:95374, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0002993 ! arthritis [Term] id: MT:0003561 name: rheumatoid arthritis namespace: Trait.ontology def: "an autoimmune disease that causes chronic inflammation of the joints and may also cause inflammation of the tissue around the joints, as well as other organs in the body" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0002993 ! arthritis [Term] id: MT:0003562 name: pancreatic beta cell physiology namespace: Trait.ontology def: "anomaly in the function of the insulin-producing cells of the islets of Langerhans in the pancreas" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0002693 ! pancreas physiology [Term] id: MT:0003563 name: pancreatic alpha cell physiology namespace: Trait.ontology def: "anomaly in the function of the glucagon-producing cells of the islets of Langerhans in the pancreas" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0002693 ! pancreas physiology [Term] id: MT:0003564 name: insulin secretion namespace: Trait.ontology def: "aberrant release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine_Medical Subject Headings, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0002694 ! pancreas secretion is_a: MT:0003562 ! pancreatic beta cell physiology [Term] id: MT:0003565 name: glucagon secretion namespace: Trait.ontology def: "anomaly in the release of this hormone secreted by the alpha cells of the islets of Langerhans; it normally plays a role in regulation of blood glucose concentration, ketone metabolism, and other biochemical and physiological processes" [MeSH:National Library of Medicine_Medical Subject Headings, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0002694 ! pancreas secretion is_a: MT:0003563 ! pancreatic alpha cell physiology [Term] id: MT:0003566 name: cell adhesion namespace: Trait.ontology def: "altered ability of a cell to adhere to another cell or to a non-cellular component of the environment" [monikat:Monika Tomczuk_Mouse Genome Informatics Curator] is_a: MT:0005621 ! cell physiology [Term] id: MT:0003568 name: uterine lumen morphology namespace: Trait.ontology def: "congenital absence of the normal opening or lumen of the uterus" [ncbi:Matthew Mailman_NCBI request, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "uterus atresia" EXACT [] is_a: MT:0001120 ! uterus morphology [Term] id: MT:0003569 name: leiomyoma namespace: Trait.ontology def: "a benign tumor derived from smooth (nonstriated) muscle " [ncbi:Matthew Mailman_NCBI request, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "fibroid tumor" EXACT [] synonym: "fibromyoma" EXACT [] is_a: MT:0002019 ! tumor incidence [Term] id: MT:0003570 name: uterine leiomyoma namespace: Trait.ontology def: "a benign tumor derived from the smooth muscle tissue of the uterus" [MeSH:National Library of Medicine_Medical Subject Headings, ncbi:Matthew Mailman_NCBI request] synonym: "fibroid uterus" EXACT [] synonym: "uterine fibroids" EXACT [] is_a: MT:0003569 ! leiomyoma [Term] id: MT:0003571 name: uterine rupture namespace: Trait.ontology def: "tearing of the uterine tissue; may be due to trauma or pregnancy complications" [MeSH:National Library of Medicine_Medical Subject Headings, ncbi:Matthew Mailman_NCBI request] synonym: "rupture of uterus" EXACT [] is_a: MT:0001120 ! uterus morphology [Term] id: MT:0003572 name: uterus development namespace: Trait.ontology def: "abnormal morphogenesis of the female muscular organ of gestation" [ncbi:Matthew Mailman_NCBI request] is_a: MT:0001120 ! uterus morphology is_a: MT:0003936 ! reproductive system development [Term] id: MT:0003573 name: rudimentary uterus namespace: Trait.ontology def: "not fully developed or remnant of the female muscular organ of gestation" [ncbi:Matthew Mailman_NCBI request] is_a: MT:0003572 ! uterus development [Term] id: MT:0003574 name: oviduct morphology namespace: Trait.ontology def: "malformation of the tube through which the ova pass from the ovary to the uterus" [smb:Susan M. Bello_Mouse Genome Informatics Curator] synonym: "abnormal fallopian tube morphology" EXACT [] is_a: MT:0001119 ! female reproductive anatomy [Term] id: MT:0003576 name: oviduct size namespace: Trait.ontology def: "reduced size of the tube through which the ova pass from the ovary to the uterus due to decreased cell number" [smb:Susan M. Bello_Mouse Genome Informatics Curator] synonym: "fallopian tube hypoplasia" EXACT [] is_a: MT:0003574 ! oviduct morphology [Term] id: MT:0003577 name: rudimentary oviduct namespace: Trait.ontology def: "not fully developed or remnant of the tube through which the ova pass from the ovary to the uterus" [smb:Susan M. Bello_Mouse Genome Informatics Curator] synonym: "rudimentary fallopian tubes" EXACT [] is_a: MT:0003574 ! oviduct morphology [Term] id: MT:0003579 name: ovarian carcinoma namespace: Trait.ontology def: "malignant neoplasm arising from ovarian tissue" [ncbi:Matthew Mailman_NCBI request] is_a: MT:0002038 ! carcinoma [Term] id: MT:0003580 name: fibroma namespace: Trait.ontology def: "a benign tumor of fibrous or fully developed connective tissue " [MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0002019 ! tumor incidence [Term] id: MT:0003581 name: ovarian fibroma namespace: Trait.ontology def: "a benign tumor of the ovary" [MeSH:National Library of Medicine_Medical Subject Headings, ncbi:Matthew Mailman_NCBI request] is_a: MT:0003580 ! fibroma [Term] id: MT:0003582 name: ovary development namespace: Trait.ontology def: "abnormal morphogenesis of the female reproductive gland containing the germ cells" [MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0001126 ! ovary morphology is_a: MT:0003936 ! reproductive system development [Term] id: MT:0003583 name: rudimentary ovary namespace: Trait.ontology def: "not fully developed or remnant of the female reproductive gland containing the germ cells" [MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0003582 ! ovary development [Term] id: MT:0003584 name: bifid ureter namespace: Trait.ontology def: "cleft of the ureter into two parts or branches" [ncbi:Matthew Mailman_NCBI request] is_a: MT:0000534 ! ureter morphology [Term] id: MT:0003585 name: ureter size namespace: Trait.ontology def: "increased size or length of the tube that conducts the urine from the renal pelvis to the bladder" [ncbi:Matthew Mailman_NCBI request, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "megaureter" EXACT [] is_a: MT:0000534 ! ureter morphology [Term] id: MT:0003586 name: ureter dilation namespace: Trait.ontology def: "abnormal distention of the ureter due to accumulation of fluid" [ncbi:Matthew Mailman_NCBI request] is_a: MT:0000534 ! ureter morphology [Term] id: MT:0003587 name: ureter obstruction namespace: Trait.ontology def: "any impediment, blockage, or reversal of the normal flow of the urine towards the bladder" [ncbi:Matthew Mailman_NCBI request] is_a: MT:0000534 ! ureter morphology [Term] id: MT:0003588 name: ureter stenosis namespace: Trait.ontology def: "abnormal narrowing or constriction of the ureter" [ncbi:Matthew Mailman_NCBI request] is_a: MT:0003585 ! ureter size [Term] id: MT:0003589 name: ureter physiology namespace: Trait.ontology def: "anomalous function of the tube that conducts the urine from the renal pelvis to the bladder" [ncbi:Matthew Mailman_NCBI request] is_a: MT:0005502 ! urinary system physiology [Term] id: MT:0003590 name: ureteral reflux namespace: Trait.ontology def: "retrograde movement of urine from the bladder to the kidney" [ncbi:Matthew Mailman_NCBI request] is_a: MT:0003589 ! ureter physiology [Term] id: MT:0003591 name: urethra atresia namespace: Trait.ontology def: "closure, or failure to develop a connection in the canal that leads from the bladder and discharges urine externally" [ncbi:Matthew Mailman_NCBI request] is_a: MT:0000537 ! urethra morphology [Term] id: MT:0003592 name: urethra stenosis namespace: Trait.ontology def: "abnormal narrowing or constriction of the urethra" [ncbi:Matthew Mailman_NCBI request] is_a: MT:0000537 ! urethra morphology [Term] id: MT:0003593 name: urethrovaginal fistula namespace: Trait.ontology def: "an abnormal anatomical passage connecting the urethra and the vagina" [MeSH:National Library of Medicine_Medical Subject Headings, ncbi:Matthew Mailman_NCBI request] is_a: MT:0000537 ! urethra morphology is_a: MT:0001139 ! vagina morphology [Term] id: MT:0003594 name: urethra size namespace: Trait.ontology def: "decreased size or length of the canal that leads from the bladder and discharges urine externally" [ncbi:Matthew Mailman_NCBI request] is_a: MT:0000537 ! urethra morphology [Term] id: MT:0003595 name: epididymal cyst namespace: Trait.ontology def: "benign growths present in the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [ncbi:Matthew Mailman_NCBI request] is_a: MT:0002631 ! epididymis morphology [Term] id: MT:0003596 name: epididymal inflammation namespace: Trait.ontology def: "local accumulation of fluid, plasma proteins, and leukocytes in the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [ncbi:Matthew Mailman_NCBI request] is_a: MT:0001846 ! tissue specific inflammatory response [Term] id: MT:0003597 name: epididymal cystademona namespace: Trait.ontology def: "a benign epithelial neoplasm with a glandular organization arising from epididymal tissue" [ncbi:Matthew Mailman_NCBI request, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002815 ! adenoma [Term] id: MT:0003598 name: epispadias namespace: Trait.ontology def: "congenital absence of the upper wall of the urethra" [MeSH:National Library of Medicine_Medical Subject Headings, ncbi:Matthew Mailman_NCBI request] is_a: MT:0000537 ! urethra morphology is_a: MT:0005187 ! penis morphology [Term] id: MT:0003599 name: penis size namespace: Trait.ontology def: "enlarged size of the organ of copulation and urination in the male" [ncbi:Matthew Mailman_NCBI request, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0005187 ! penis morphology [Term] id: MT:0003600 name: ectopic kidney namespace: Trait.ontology def: "kidney located in a position not normally occupied by this tissue" [ncbi:Matthew Mailman_NCBI request] is_a: MT:0002135 ! kidney morphology [Term] id: MT:0003601 name: bifid kidney namespace: Trait.ontology def: "cleft of the kidney into two parts or branches, often having the appearance of two lobes" [ncbi:Matthew Mailman_NCBI request] is_a: MT:0003650 ! kidney shape [Term] id: MT:0003602 name: renal hamartoma namespace: Trait.ontology def: "a benign formation of a mass of tissue of disproportionate size and distribution in the kidney, but composed of an overgrowth of mature cells and tissues that normally occur in this tissue" [MeSH:National Library of Medicine_Medical Subject Headings, ncbi:Matthew Mailman_NCBI request] is_a: MT:0002019 ! tumor incidence [Term] id: MT:0003603 name: renal hemangioblastoma namespace: Trait.ontology def: "a benign cyst-like tumor of the kidney that is composed of multiple capillary and sinusoidal channels lined with endothelial cells " [MeSH:National Library of Medicine_Medical Subject Headings, ncbi:Matthew Mailman_NCBI request] is_a: MT:0002019 ! tumor incidence [Term] id: MT:0003604 name: single kidney namespace: Trait.ontology def: "presence of only one of the paired organs responsible for urine secretion" [ncbi:Matthew Mailman_NCBI request] is_a: MT:0000527 ! kidney development [Term] id: MT:0003605 name: fused kidneys namespace: Trait.ontology def: "a defect in which there is a single malformed organ resulting from partial or complete fusion of the two renal anlage" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, ncbi:Matthew Mailman_NCBI request, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "cake kidney" NARROW [] synonym: "disk kidney" NARROW [] synonym: "horseshoe kidney" NARROW [] is_a: MT:0000527 ! kidney development [Term] id: MT:0003606 name: kidney function namespace: Trait.ontology def: "cessation of renal function" [ncbi:Matthew Mailman_NCBI request] is_a: MT:0002136 ! kidney physiology [Term] id: MT:0003607 name: prostate physiology namespace: Trait.ontology def: "malfunction of the gland in males that secretes part of the seminiferous fluid" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0003698 ! male reproductive system physiology is_a: MT:0005647 ! sex gland physiology [Term] id: MT:0003608 name: prostate inflammation namespace: Trait.ontology def: "local accumulation of fluid, plasma proteins, and leukocytes in the prostate" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] is_a: MT:0001846 ! tissue specific inflammatory response is_a: MT:0002254 ! reproductive system inflammation is_a: MT:0003607 ! prostate physiology [Term] id: MT:0003610 name: scrotum cell number namespace: Trait.ontology def: "increase in size, usually due to an increase in cell number, of the external sac of skin that encloses the testes" [ncbi:Matthew Mailman_NCBI request] is_a: MT:0001150 ! scrotum size [Term] id: MT:0003612 name: bifid scrotum namespace: Trait.ontology def: "cleft of the scrotum into two parts or branches, often having the appearance of two lobes " [ncbi:Matthew Mailman_NCBI request] is_a: MT:0002669 ! scrotum morphology [Term] id: MT:0003613 name: kidney medulla development namespace: Trait.ontology is_a: MT:0000527 ! kidney development [Term] id: MT:0003614 name: urinary bladder prolapse namespace: Trait.ontology def: "downward movement, and possible external appearance, of the bladder through the urethra" [ncbi:Matthew Mailman_NCBI request] is_a: MT:0000538 ! urinary bladder morphology [Term] id: MT:0003615 name: urinary bladder diverticulum namespace: Trait.ontology def: "a pouch or sac protruding from the urinary bladder wall" [ncbi:Matthew Mailman_NCBI request] is_a: MT:0000538 ! urinary bladder morphology [Term] id: MT:0003616 name: urachus namespace: Trait.ontology def: "fibrous connection between bladder and umbilicus" [ncbi:Matthew Mailman_NCBI request] is_a: MT:0000538 ! urinary bladder morphology is_a: MT:0001725 ! umbilical cord morphology [Term] id: MT:0003617 name: urinary bladder cell number namespace: Trait.ontology def: "reduced number of cells comprising the urinary bladder, often resulting in a small size" [ncbi:Matthew Mailman_NCBI request] is_a: MT:0000538 ! urinary bladder morphology [Term] id: MT:0003618 name: cervical opening size namespace: Trait.ontology def: "narrowing of the cervical opening" [ncbi:Matthew Mailman_NCBI request] is_a: MT:0001135 ! cervix morphology [Term] id: MT:0003619 name: urine color namespace: Trait.ontology def: "any alteration from the usual straw-coloration of the urine" [ncbi:Matthew Mailman_NCBI request] is_a: MT:0001757 ! urine chemistry [Term] id: MT:0003620 name: urine output namespace: Trait.ontology def: "decreased volume of urine produced and excreted" [ncbi:Matthew Mailman_NCBI request] is_a: MT:0001756 ! urination is_a: MT:0005555 ! kidney excretion [Term] id: MT:0003621 name: dysuria namespace: Trait.ontology def: "difficult or painful urination" [ncbi:Matthew Mailman_NCBI request] is_a: MT:0001756 ! urination [Term] id: MT:0003622 name: incomplete emptying of bladder namespace: Trait.ontology def: "upon urination, some urine is retained in the bladder instead of being excreted" [ncbi:Matthew Mailman_NCBI request] is_a: MT:0001756 ! urination [Term] id: MT:0003623 name: hydrocele namespace: Trait.ontology def: "accumulation of fluid around testes" [ncbi:Matthew Mailman_NCBI request] is_a: MT:0001146 ! testis morphology [Term] id: MT:0003626 name: kidney medulla cell number namespace: Trait.ontology def: "decreased size due to increased cell number of the inner portion of the kidney consisting of the renal pyramids" [ncbi:Matthew Mailman_NCBI request, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0003014 ! kidney medulla morphology is_a: MT:0003446 ! kidney cell number [Term] id: MT:0003627 name: lymphocyte rolling namespace: Trait.ontology def: "anomaly in the number or velocity of lymphocytes rolling along the luminal aspects of high endothelial venules" [J:95656, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0003156 ! lymphocyte migration/homing [Term] id: MT:0003628 name: lymphocyte adhesion namespace: Trait.ontology def: "anomaly in the number of or process by which lymphocytes adhere to the luminal aspects of high endothelial venules prior to transmigration out of the vessel" [J:95656, smb:Susan M. Bello_Mouse Genome Informatics Curator] synonym: "abnormal lymphocyte firm adhesion" EXACT [] is_a: MT:0003156 ! lymphocyte migration/homing [Term] id: MT:0003629 name: lymphocyte transmigration namespace: Trait.ontology def: "anomaly in the number of or process by which lymphocytes cross out of high endothelial venules into the surrounding tissue" [J:95656, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0003156 ! lymphocyte migration/homing [Term] id: MT:0003630 name: urothelium namespace: Trait.ontology def: "malformation of the mucus lining in organs of the urinary tract, consisting in the bladder of three to seven cell layers" [J:95622, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0000516 ! urinary system morphology [Term] id: MT:0003631 name: nervous system trait namespace: Trait.ontology alt_id: MT:0005368 alt_id: MT:0005383 synonym: "central nervous system phenotype" EXACT [] synonym: "CNS" EXACT [] synonym: "peripheral nervous system phenotype" EXACT [] synonym: "PNS" EXACT [] is_a: MT:0000001 ! Trait [Term] id: MT:0003632 name: nervous system morphology namespace: Trait.ontology alt_id: MT:0000769 alt_id: MT:0000957 alt_id: MT:0002153 alt_id: MT:0002157 alt_id: MT:0002170 alt_id: MT:0002171 synonym: "abnormal central nervous system morphology" EXACT [] synonym: "abnormal peripheral nervous system" EXACT [] synonym: "abnormal peripheral nervous system morphology" EXACT [] synonym: "central nervous system abnormalities" EXACT [] synonym: "central nervous system defects" EXACT [] synonym: "central nervous system: other dysmorphology" EXACT [] synonym: "other abnormal central nervous system morphology" EXACT [] synonym: "peripheral nervous system abnormalities" EXACT [] synonym: "peripheral nervous system abnormality" EXACT [] synonym: "peripheral nervous system defects" EXACT [] synonym: "peripheral nervous system: dysmorphology" EXACT [] xref: GO:0007417 xref: MGI:2173613 xref: MGI:2173617 is_a: MT:0003631 ! nervous system trait [Term] id: MT:0003633 name: nervous system physiology namespace: Trait.ontology alt_id: MT:0000945 alt_id: MT:0001887 alt_id: MT:0001910 alt_id: MT:0001918 alt_id: MT:0002155 alt_id: MT:0002158 synonym: "abnormal brain function" NARROW [] synonym: "abnormal central nervous system physiology" NARROW [] synonym: "abnormal peripheral nervous system physiology" NARROW [] synonym: "central nervous system functional abnormalities" NARROW [] synonym: "central nervous system: other functional anomalies" NARROW [] synonym: "peripheral nervous system: functional anomalies" NARROW [] xref: MGI:2173615 xref: MGI:2173618 is_a: MT:0003631 ! nervous system trait [Term] id: MT:0003634 name: glia morphology namespace: Trait.ontology def: "malformation or absence of non-neuronal cells of the nervous system that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons" [MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0003632 ! nervous system morphology [Term] id: MT:0003635 name: synaptic transmission namespace: Trait.ontology alt_id: MT:0002202 def: "defect in the communication from a neuron to a target across a synapse " [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal neurotransmission" EXACT [] is_a: MT:0003633 ! nervous system physiology [Term] id: MT:0003637 name: cochlear ganglion cell number namespace: Trait.ontology def: "reduced numbers of the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain and resides on the cochlear part of the vestibulocochlear nerve (eighth cranial nerve)" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "reduced number of spiral ganglion cells" EXACT [] synonym: "spiral ganglion hypoplasia" EXACT [] is_a: MT:0003986 ! cochlear ganglion size [Term] id: MT:0003638 name: response/metabolism to endogenous compounds namespace: Trait.ontology def: "altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] synonym: "abnormal metabolism of endogenous compounds" EXACT [] is_a: MT:0002121 ! metabolism [Term] id: MT:0003639 name: response to vitamins namespace: Trait.ontology def: "altered ability or inability to respond to or metabolize a group of organic substances that are required in trace amounts for the normal metabolic homeostasis of the body " [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal metabolism of vitamins" EXACT [] is_a: MT:0003638 ! response/metabolism to endogenous compounds is_a: MT:0004019 ! vitamin homeostasis [Term] id: MT:0003640 name: susceptibility to lung neoplasm namespace: Trait.ontology def: "reduced likelihood of developing an abnormal growth of lung tissue" [J:95491, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0005514 ! susceptibility to tumor development [Term] id: MT:0003641 name: lung size namespace: Trait.ontology def: "reduced size of the lung relative to normal" [J:95332, smb:Susan M. Bello_Mouse Genome Informatics Curator] subset: slim_chkn is_a: MT:0001175 ! lung morphology [Term] id: MT:0003646 name: muscle stamina namespace: Trait.ontology def: "increased muscle exhaustion or increased susceptibility to muscle exhaustion" [J:96306] synonym: "muscle fatigability" EXACT [] is_a: MT:0002106 ! muscle physiology [Term] id: MT:0003647 name: oligodendrocyte number namespace: Trait.ontology def: "absence of the neuroglia of the central nervous system that form the insulating myelin sheath of axons in the CNS" [MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0000953 ! oligodendrocyte morphology [Term] id: MT:0003648 name: radial glial cell morphology namespace: Trait.ontology def: "anomalous structure, number, or composition of the supporting cells of the developing central nervous system that guide neuronal migration during development and exchange metabolites with developing and migrating neurons; these cells differentiate into astrocytes and some neuronal types in the adult" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] synonym: "abnormal radial glia" EXACT [] is_a: MT:0000952 ! CNS glia morphology is_a: MT:0006008 ! neurogenesis [Term] id: MT:0003650 name: kidney shape namespace: Trait.ontology def: "alteration in the size, shape or organization of cells of the kidney" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, J:67732] synonym: "kidney dysplasia" EXACT [] is_a: MT:0002135 ! kidney morphology [Term] id: MT:0003651 name: axon outgrowth namespace: Trait.ontology def: "defect/abnormality in the ability of an axon to extend from a neuron cell body" [J:96121, monikat:Monika Tomczuk_Mouse Genome Informatics Curator] is_a: MT:0006008 ! neurogenesis [Term] id: MT:0003652 name: skin turgor namespace: Trait.ontology def: "anomaly in the ability of the skin to resist deformation; influential factors include dehydration and age" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] synonym: "abnormal turgor" EXACT [] is_a: MT:0001191 ! skin condition [Term] id: MT:0003656 name: erythrocyte physiology namespace: Trait.ontology def: "functional anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] is_a: MT:0001545 ! hematopoietic system physiology [Term] id: MT:0003657 name: erythrocyte lysis namespace: Trait.ontology def: "increase or decrease in the ability of RBCs to withstand changes in osmolarity" [smb:Susan M. Bello_Mouse Genome Informatics Curator] synonym: "erythrocyte fragility" EXACT [] is_a: MT:0003656 ! erythrocyte physiology [Term] id: MT:0003658 name: capillary integrity namespace: Trait.ontology def: "any measurable characteristic pertaining to the the structural completeness or structural soundness minute blood vessels that connect arterioles and venules" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator", RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] is_a: MT:0000088 ! blood vessel integrity relationship: part_of MT:0000087 ! capillary morphology [Term] id: MT:0003659 name: lymph circulation namespace: Trait.ontology def: "flow of the lymph from the tissues into the veins of the circulatory system" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] is_a: MT:0001790 ! immune system physiology is_a: MT:0002128 ! blood circulation [Term] id: MT:0003661 name: locus ceruleus morphology namespace: Trait.ontology def: "anomaly in a dense cluster of neurons within the dorsorostral pons; it is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic" [J:96328, Principles of Neural Science_3rd edition:ISBN 0-8385-8034-3] is_a: MT:0000848 ! pons morphology [Term] id: MT:0003662 name: epiphyseal plate proliferative zone morphology namespace: Trait.ontology def: "germinal layer of the epiphyseal plate where cells are actively dividing as well as producing extracellular matrix" [J:96254, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0000164 ! cartilage development is_a: MT:0003055 ! epiphyseal plate morphology [Term] id: MT:0003663 name: thermosensation namespace: Trait.ontology synonym: "abnormal thermal preference" EXACT [] synonym: "impaired thermosensation" EXACT [] is_a: MT:0002067 ! sensory capabilities/reflexes/nociception [Term] id: MT:0003664 name: ocular pterygium namespace: Trait.ontology def: "mass of tissue arising from the conjunctiva of the inner corner of the eye that obstructs vision by growing over the cornea" [J:96018, monikat:Monika Tomczuk_Mouse Genome Informatics Curator] is_a: MT:0001310 ! conjunctiva morphology [Term] id: MT:0003665 name: endophthalmitis namespace: Trait.ontology def: "inflammation of the internal structures of the tissues in the eyeball" [J:96018, monikat:Monika Tomczuk_Mouse Genome Informatics Curator] is_a: MT:0001851 ! eye inflammation is_a: MT:0005195 ! posterior eye segment morphology [Term] id: MT:0003666 name: sperm capacitation namespace: Trait.ontology def: "anomaly in the change undergone by spermatozoa in the female genital tract that enables them to penetrate and fertilize an egg" [J:96669, monikat:Monika Tomczuk_Mouse Genome Informatics Curator] is_a: MT:0003698 ! male reproductive system physiology [Term] id: MT:0003667 name: hemangiosarcoma namespace: Trait.ontology def: "a malignant tumor characterized by rapidly proliferating, extensively infiltrating, anaplastic cells derived from blood vessels and appear as irregular blood-filled or lumpy sacs that are typically filled with blood; rupture of the tumor can cause rapid death from bleeding" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, J:53511, MeSH:National Library of Medicine_Medical Subject Headings, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "angiosarcoma" EXACT [] is_a: MT:0002032 ! sarcoma [Term] id: MT:0003668 name: periodontal ligament morphology namespace: Trait.ontology def: "any structural anomaly in the fibrous connective tissue that surrounds the root of a tooth, separating it from and attaching it to the alveolar bone; normally extends from the base of the gingival mucosa to the fundus of the bony socket, and its main function is to hold the tooth in its socket" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, J:66512] synonym: "abnormal periodontium" EXACT [] is_a: MT:0002100 ! tooth morphology [Term] id: MT:0003670 name: glomerular capsule size namespace: Trait.ontology def: "an expansion in volume of the expanded beginning of a nephron that contains the glomerulus" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, J:91499] synonym: "dilated Bowman's capsule" EXACT [] is_a: MT:0002828 ! glomerular capsule morphology [Term] id: MT:0003671 name: eyelid opening namespace: Trait.ontology def: "partially or completely shut eyes " [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0001340 ! eyelid morphology [Term] id: MT:0003672 name: ureter development namespace: Trait.ontology def: "anomalous differentiation of the tube that conducts the urine from the renal pelvis to the bladder" [J:96485, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0000534 ! ureter morphology is_a: MT:0003942 ! urinary system development [Term] id: MT:0003673 name: inguinal canal morphology namespace: Trait.ontology def: "the passage in the lower abdominal wall through which the spermatic cord in the male or the round ligament in the female, nerves and vessels pass from the pelvic cavity to the scrotum or labia majora, respectively " [MeSH:National Library of Medicine_Medical Subject Headings, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002160 ! reproductive system morphology [Term] id: MT:0003674 name: oxidative stress namespace: Trait.ontology def: "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0003186 ! redox activity [Term] id: MT:0003675 name: kidney cysts namespace: Trait.ontology alt_id: MT:0005347 def: "abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "cystic kidney" EXACT [] synonym: "renal cysts" EXACT [] is_a: MT:0002135 ! kidney morphology [Term] id: MT:0003677 name: ear lobe morphology namespace: Trait.ontology def: "form or structure of the soft tissue at the base of the outer ear; consists of fat and fibrous tissue not reinforced by the auricular cartilage " [ncbi:Matthew Mailman_NCBI request, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002177 ! outer ear morphology [Term] id: MT:0003679 name: ear lobe size namespace: Trait.ontology def: "length, width, thickness, or area of the ear lobes" [ncbi:Matthew Mailman_NCBI request] synonym: "hypoplastic ear lobes" EXACT [] is_a: MT:0003677 ! ear lobe morphology [Term] id: MT:0003684 name: inferior olivary complex morphology namespace: Trait.ontology def: "any structural abnormality in the capsule-shaped structure in the ventral medulla located just lateral and dorsal to the medullary pyramids; neurons in the inferior olivary nucleus are the source of climbing fiber input to the cerebellar cortex and have been implicated in various functions, such as learning and timing of movements" [Principles of Neural Science_3rd edition:ISBN 0-8385-8034-3] synonym: "abnormal inferior olivary nucleus" EXACT [] synonym: "abnormal inferior olive" EXACT [] synonym: "abnormal oliva" EXACT [] is_a: MT:0000846 ! medulla oblongata [Term] id: MT:0003685 name: cardiac ganglion morphology namespace: Trait.ontology def: "any anomaly of the parasympathetic ganglia of the cardiac plexus between the arch of the aorta and the bifurcation of the pulmonary artery " [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal cardiac ganglia" EXACT [] synonym: "abnormal Wrisberg ganglion" EXACT [] is_a: MT:0001034 ! parasympathetic ganglia morphology [Term] id: MT:0003686 name: eye muscle morphology namespace: Trait.ontology def: "malformation of the muscles of the eye" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0002092 ! eye morphology is_a: MT:0002108 ! muscle morphology [Term] id: MT:0003687 name: intraocular muscle morphology namespace: Trait.ontology def: "malformation of the smooth muscles within the eye" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0000767 ! smooth muscle morphology is_a: MT:0003686 ! eye muscle morphology [Term] id: MT:0003688 name: eye muscle strength namespace: Trait.ontology is_a: MT:0000747 ! muscle strength is_a: MT:0001389 ! eye movements [Term] id: MT:0003689 name: ability to move the eye muscles namespace: Trait.ontology is_a: MT:0000753 ! ability to move is_a: MT:0001389 ! eye movements is_a: MT:0002106 ! muscle physiology [Term] id: MT:0003690 name: glial cell physiology namespace: Trait.ontology def: "anomalous function of non-neuronal cells of the central nervous system that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons" [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal glial cell function" EXACT [] is_a: MT:0003633 ! nervous system physiology [Term] id: MT:0003691 name: microglial cell physiology namespace: Trait.ontology def: "anomalous activity of the small neuroglial cells, possibly of mesodermal origin, which may become phagocytic, in areas of neural damage or inflammation" [hdene:Howard Dene_Mouse Genome Informatics Curator] is_a: MT:0003690 ! glial cell physiology [Term] id: MT:0003692 name: xanthoma namespace: Trait.ontology def: "a deposit of cholesterol rich material in a tissue, most often in the skin but also seen in tendons and in the brain" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0002118 ! lipid homeostasis [Term] id: MT:0003693 name: embryo hatching namespace: Trait.ontology def: "anomalies in the ability of the embryo to break out of the zona pellucida, the thick solid transparent outer membrane that surrounds the developing ovum and embryo prior to implantation, may be seen in vivo or in cultured embryos" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0001672 ! embryogenesis/ development [Term] id: MT:0003696 name: zona pellucida morphology namespace: Trait.ontology def: "anomaly or absence of the thick solid transparent outer membrane that surrounds the developing ovum and embryo prior to implantation" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0001131 ! ovarian follicle morphology [Term] id: MT:0003698 name: male reproductive system physiology namespace: Trait.ontology def: "anomaly in the function of the male organs associated with producing offspring " [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0001919 ! reproductive system physiology [Term] id: MT:0003699 name: female reproductive system physiology namespace: Trait.ontology def: "anomaly in the function of the female organs associated with producing offspring" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] subset: slim_cattle subset: slim_pig is_a: MT:0001919 ! reproductive system physiology [Term] id: MT:0003700 name: oviduct transport namespace: Trait.ontology def: "increased or decreased rate of passage of embryos or oocytes from the ovary to the uterus" [J:97633, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0004015 ! oviduct environment [Term] id: MT:0003701 name: level of sister chromatid exchange namespace: Trait.ontology def: "increased number of crossovers between sister chromatids during meiosis resulting in increased numbers of reciprocal exchanges of DNA between the two chromosomes" [hdene:Howard Dene_Mouse Genome Informatics Curator, J:97667] is_a: MT:0003702 ! chromosome morphology [Term] id: MT:0003702 name: chromosome morphology namespace: Trait.ontology def: "anomalies in the structure of the compact, intertwined molecules of DNA found in the nucleus which carry genetic information " [hdene:Howard Dene_Mouse Genome Informatics Curator] is_a: MT:0003111 ! nucleus morphology [Term] id: MT:0003703 name: vestibulocochlear ganglion morphology namespace: Trait.ontology alt_id: MT:0001090 def: "malformed group of neuron cell bodies associated with the eighth cranial nerve during embryogenesis; splits in later development to form the cochlear and vestibular ganglia" [smb:Susan M. Bello_Mouse Genome Informatics Curator] synonym: "abnormal spiral ganglion" EXACT [] synonym: "abnormal vestibular cochlear ganglion" EXACT [] synonym: "abnormal vestibular cochlear ganglion morphology" EXACT [] is_a: MT:0003861 ! nervous system development [Term] id: MT:0003704 name: hair follicle development namespace: Trait.ontology def: "anomalous development of the epidermis from which the hair shaft develops" [monikat:Monika Tomczuk_Mouse Genome Informatics Curator] is_a: MT:0000367 ! coat/ hair morphology [Term] id: MT:0003705 name: hypodermis morphology namespace: Trait.ontology def: "malformed or atypical condition of the innermost and thickest layer of the skin composed of loose connective tissue containing adipocytes" [monikat:Monika Tomczuk_Mouse Genome Informatics Curator] is_a: MT:0002060 ! skin morphology [Term] id: MT:0003706 name: nucleus count namespace: Trait.ontology def: "absent or greater than one nuclei present per cell body when one is expected; often due to failed cytokinesis or events leading to apoptosis" [pg:Philip Groth submission] is_a: MT:0000358 ! cell content/ morphology [Term] id: MT:0003710 name: vascularization namespace: Trait.ontology def: "new blood vessel development" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] is_a: MT:0000249 ! blood vessel physiology [Term] id: MT:0003713 name: ear rotation namespace: Trait.ontology def: "orientation of the outer ears in relation to the anterior-posterior body axis, does not refer to the point of emergence on the head" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, ncbi:Matthew Mailman_NCBI request] is_a: MT:0002177 ! outer ear morphology [Term] id: MT:0003714 name: absence of platelets namespace: Trait.ontology def: "lack of non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0003179 ! platelet count [Term] id: MT:0003717 name: skin color namespace: Trait.ontology def: "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "pale skin" EXACT [] synonym: "pallid" EXACT [] is_a: MT:0001191 ! skin condition [Term] id: MT:0003718 name: maternal effect namespace: Trait.ontology def: "expression of a phenotypic trait in an female animal's offspring that is dependent on the maternal genotype" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0005389 ! reproductive system trait [Term] id: MT:0003719 name: pericyte integrity namespace: Trait.ontology def: "any measurable characteristic pertaining to the the structural completeness or structural soundness of the connective tissue cells that occurs around capillaries or other small blood vessels" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] relationship: part_of MT:0000088 ! blood vessel integrity [Term] id: MT:0003720 name: neural tube closure namespace: Trait.ontology def: "abnormal invagination and fusion of the neuroepithelial layer in early development" [J:99099, monikat:Monika Tomczuk_Mouse Genome Informatics Curator] is_a: MT:0002151 ! neural tube morphology/development [Term] id: MT:0003721 name: tumor growth/size namespace: Trait.ontology def: "greater than expected development of tumorous growth when compared to controls" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0003448 ! tumor morphology [Term] id: MT:0003722 name: ureter number namespace: Trait.ontology def: "missing the tube that conducts the urine from the renal pelvis to the bladder" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0000534 ! ureter morphology [Term] id: MT:0003723 name: long bone morphology namespace: Trait.ontology def: "malformation of any of the several elongated bones of the extremities" [monikat:Monika Tomczuk_Mouse Genome Informatics Curator] subset: slim_chkn subset: slim_pig is_a: MT:0002115 ! skeleton extremities morphology [Term] id: MT:0003724 name: susceptibility to induced arthritis namespace: Trait.ontology def: "more likely to be stricken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [acv:Alicia Valenzuela_Genetic Resources Curator] is_a: MT:0002993 ! arthritis [Term] id: MT:0003726 name: autoantibody level namespace: Trait.ontology def: "reduced level of antibodies to self-antigens present in the sera" [acv:Alicia Valenzuela_Genetic Resources Curator, csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0001844 ! autoimmune response [Term] id: MT:0003727 name: retinal layer morphology namespace: Trait.ontology def: "malformation in any of the layers that make up the retina" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0001325 ! retina morphology [Term] id: MT:0003728 name: photoreceptor layer namespace: Trait.ontology def: "malformation/anomalous structure of the photoreceptor layer" [monikat:Monika Tomczuk_Mouse Genome Informatics Curator] is_a: MT:0006069 ! retinal neuronal layer morphology [Term] id: MT:0003729 name: photoreceptor outer segments namespace: Trait.ontology def: "malformation/anomalous structure of the photoreceptor layer which contains stacks of membranous discs that are rich in the visual pigment rhodopsin " [monikat:Monika Tomczuk_Mouse Genome Informatics Curator] is_a: MT:0003728 ! photoreceptor layer [Term] id: MT:0003730 name: photoreceptor inner segments namespace: Trait.ontology def: "malformation/anomalous structure of the photoreceptor layer which contains the machinery of the cell (mitochondria, golgi, endoplasmic reticulum, etc)" [monikat:Monika Tomczuk_Mouse Genome Informatics Curator] is_a: MT:0003728 ! photoreceptor layer [Term] id: MT:0003731 name: outer nuclear layer morphology namespace: Trait.ontology def: "malformation/anomalous structure of the retinal layer that contains the nuclei and cell bodies of rods and cones" [monikat:Monika Tomczuk_Mouse Genome Informatics Curator] is_a: MT:0006069 ! retinal neuronal layer morphology [Term] id: MT:0003732 name: outer plexiform layer morphology namespace: Trait.ontology def: "malformation/anomalous structure of the retinal layer that is the site of synapses between the rods and cones (axons) and the horizontal and bipolar cells (dendrites)" [monikat:Monika Tomczuk_Mouse Genome Informatics Curator] is_a: MT:0006069 ! retinal neuronal layer morphology [Term] id: MT:0003733 name: inner nuclear layer morphology namespace: Trait.ontology def: "malformation/anomalous structure of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells" [monikat:Monika Tomczuk_Mouse Genome Informatics Curator] is_a: MT:0006069 ! retinal neuronal layer morphology [Term] id: MT:0003734 name: inner plexiform layer morphology namespace: Trait.ontology def: "malformation/anomalous structure of the retinal cell layer where bipolar and amacrine cell axons synapse with ganglion cell dendrites" [monikat:Monika Tomczuk_Mouse Genome Informatics Curator] is_a: MT:0006069 ! retinal neuronal layer morphology [Term] id: MT:0003737 name: outer ear cartilage morphology namespace: Trait.ontology def: "structure or form of the cartilage of the outer ear" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, ncbi:Matthew Mailman_NCBI request] is_a: MT:0002177 ! outer ear morphology [Term] id: MT:0003739 name: middle ear ossicle size namespace: Trait.ontology def: "length, width, or volume of the three small bones of the middle ear" [ncbi:Matthew Mailman_NCBI request] is_a: MT:0005105 ! middle ear ossicle morphology [Term] id: MT:0003743 name: facial morphology namespace: Trait.ontology def: "anomalous structure or development of the face" [ncbi:Matthew Mailman_NCBI request] is_a: MT:0000432 ! head morphology [Term] id: MT:0003744 name: orofacial morphology namespace: Trait.ontology def: "anomalous structure or development of the oral cavities of the face" [ncbi:Matthew Mailman_NCBI request] is_a: MT:0003743 ! facial morphology [Term] id: MT:0003745 name: mucosal lining of the mouth namespace: Trait.ontology def: "anomalous structure or development of the mucus -secreting tissue that lines the oral cavity" [ncbi:Matthew Mailman_NCBI request] is_a: MT:0000452 ! mouth morphology [Term] id: MT:0003746 name: stomatitis namespace: Trait.ontology def: "inflammation of the mucous lining of the mouth" [ncbi:Matthew Mailman_NCBI request] is_a: MT:0001846 ! tissue specific inflammatory response is_a: MT:0003745 ! mucosal lining of the mouth [Term] id: MT:0003747 name: mouth mucosal ulceration namespace: Trait.ontology def: "lesions through the mucous membrane of the mouth" [ncbi:Matthew Mailman_NCBI request] is_a: MT:0003745 ! mucosal lining of the mouth [Term] id: MT:0003748 name: oral mucosa hemangioma namespace: Trait.ontology def: "proliferation of blood vessels in the oral mucosa that leads to a mass that resembles a benign neoplasm" [ncbi:Matthew Mailman_NCBI request] is_a: MT:0002947 ! hemangioma is_a: MT:0003750 ! mouth tumor [Term] id: MT:0003749 name: down-turned corners of mouth namespace: Trait.ontology def: "the lateral points of the oral cavity opening appear in a lower position that the rest of the lips" [ncbi:Matthew Mailman_NCBI request] synonym: "down slanted corners of mouth" EXACT [] synonym: "down turned corners of mouth" EXACT [] synonym: "down-slanted corners of mouth" EXACT [] is_a: MT:0000452 ! mouth morphology [Term] id: MT:0003750 name: mouth tumor namespace: Trait.ontology def: "presence of abnormal rapidly proliferating cells in the mouth, usually in the form of a distinct mass" [ncbi:Matthew Mailman_NCBI request] is_a: MT:0002019 ! tumor incidence [Term] id: MT:0003751 name: oral leukoplakia namespace: Trait.ontology def: "white precancerous lesions of the mucous membranes of the oral cavity" [ncbi:Matthew Mailman_NCBI request] is_a: MT:0003750 ! mouth tumor [Term] id: MT:0003752 name: oral papilloma namespace: Trait.ontology def: "benign epithelial tumor of the oral cavity" [ncbi:Matthew Mailman_NCBI request] is_a: MT:0002014 ! papilloma is_a: MT:0003750 ! mouth tumor [Term] id: MT:0003753 name: lip papilloma namespace: Trait.ontology def: "benign epithelial tumor of the lip of the oral cavity" [ncbi:Matthew Mailman_NCBI request] is_a: MT:0003752 ! oral papilloma is_a: MT:0003780 ! lip tumor [Term] id: MT:0003754 name: gingival papilloma namespace: Trait.ontology def: "benign epithelial tumor of the oral gum tissue" [ncbi:Matthew Mailman_NCBI request] is_a: MT:0003752 ! oral papilloma [Term] id: MT:0003755 name: palate namespace: Trait.ontology def: "anomaly in the roof of the mouth in vertebrates formed anteriorly by a bony projection of the upper jaw (hard palate) and posteriorly by the fold of connective tissue (soft palate) " [ncbi:Matthew Mailman_NCBI request] is_a: MT:0000452 ! mouth morphology [Term] id: MT:0003756 name: hard palate namespace: Trait.ontology def: "abnormality in the anterior part of the palate that is supported by and includes the palatal extensions of the maxillary and palatine bones " [ncbi:Matthew Mailman_NCBI request] is_a: MT:0003755 ! palate [Term] id: MT:0003759 name: palate width namespace: Trait.ontology def: "abnormally wide shape to the roof of the oral cavity" [ncbi:Matthew Mailman_NCBI request] synonym: "wide palate" EXACT [] is_a: MT:0003755 ! palate [Term] id: MT:0003760 name: palate length namespace: Trait.ontology def: "length to the roof of the oral cavity" [ncbi:Matthew Mailman_NCBI request, smb:MGI_curator] is_a: MT:0003755 ! palate [Term] id: MT:0003761 name: arched palate namespace: Trait.ontology def: "concave shape to the roof of the oral cavity" [ncbi:Matthew Mailman_NCBI request] is_a: MT:0003755 ! palate [Term] id: MT:0003762 name: immune organ physiology namespace: Trait.ontology def: "abnormal function of the organs of the immune system" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0001790 ! immune system physiology [Term] id: MT:0003763 name: thymus physiology namespace: Trait.ontology def: "anomalous function of the primary lymphoid organ that is required for immune system development" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001545 ! hematopoietic system physiology is_a: MT:0003762 ! immune organ physiology [Term] id: MT:0003764 name: palatal depth namespace: Trait.ontology def: "any change in the average distance of the deepest point in the midline of the palate relative to the midline point on the anterior crest of the alveolar gum pad ridge" [ncbi:Matthew Mailman_NCBI request] is_a: MT:0003755 ! palate [Term] id: MT:0003767 name: palatial inflammation namespace: Trait.ontology def: "local accumulation of fluid, plasma proteins and leukocytes in the palate" [MeSH:National Library of Medicine_Medical Subject Headings, ncbi:Matthew Mailman_NCBI request] is_a: MT:0001846 ! tissue specific inflammatory response is_a: MT:0003755 ! palate [Term] id: MT:0003768 name: palatal telangiectases* namespace: Trait.ontology def: "vascular lesion formed by dilation of a group of small blood vessels in the palate" [ncbi:Matthew Mailman_NCBI request] is_a: MT:0003755 ! palate [Term] id: MT:0003769 name: lip morphology namespace: Trait.ontology def: "anomalous structure or development of the fleshy margins of the mouth" [ncbi:Matthew Mailman_NCBI request] is_a: MT:0003744 ! orofacial morphology [Term] id: MT:0003770 name: lip ulceration namespace: Trait.ontology def: "lesions through the mucous membrane of the inner surface of the lip" [ncbi:Matthew Mailman_NCBI request] is_a: MT:0003769 ! lip morphology [Term] id: MT:0003771 name: lip shape namespace: Trait.ontology def: "changes in the characteristic contours of the fleshy margins of the mouth" [ncbi:Matthew Mailman_NCBI request] is_a: MT:0003769 ! lip morphology [Term] id: MT:0003772 name: lip pits namespace: Trait.ontology def: "a hollow or depression in the fleshy margins of the mouth" [ncbi:Matthew Mailman_NCBI request] is_a: MT:0003769 ! lip morphology [Term] id: MT:0003773 name: everted lip namespace: Trait.ontology def: "an outward turning of the inner surface of the lip" [ncbi:Matthew Mailman_NCBI request] is_a: MT:0003769 ! lip morphology [Term] id: MT:0003774 name: fleshy lip namespace: Trait.ontology def: "lips having an abundance and often an excess of soft tissue" [ncbi:Matthew Mailman_NCBI request] synonym: "full lip" EXACT [] synonym: "thick lip" EXACT [] is_a: MT:0003769 ! lip morphology [Term] id: MT:0003777 name: lip inflammation namespace: Trait.ontology def: "local accumulation of fluid, plasma proteins and leukocytes in the lips" [MeSH:National Library of Medicine_Medical Subject Headings, ncbi:Matthew Mailman_NCBI request] is_a: MT:0001846 ! tissue specific inflammatory response is_a: MT:0003769 ! lip morphology [Term] id: MT:0003778 name: lip telangiectases* namespace: Trait.ontology def: "vascular lesion formed by dilation of a group of small blood vessels in the lip" [ncbi:Matthew Mailman_NCBI request] is_a: MT:0003769 ! lip morphology [Term] id: MT:0003779 name: lip cysts namespace: Trait.ontology def: "fluid-filled membranous sacs present in the lips" [ncbi:Matthew Mailman_NCBI request] is_a: MT:0003769 ! lip morphology [Term] id: MT:0003780 name: lip tumor namespace: Trait.ontology def: "presence of abnormal rapidly proliferating cells in the lip, usually in the form of a distinct mass" [ncbi:Matthew Mailman_NCBI request] is_a: MT:0002019 ! tumor incidence [Term] id: MT:0003781 name: lip neuroma namespace: Trait.ontology def: "tumor derived from nerve cells or fibers residing in the lip" [ncbi:Matthew Mailman_NCBI request] is_a: MT:0003780 ! lip tumor [Term] id: MT:0003783 name: tented upper lip namespace: Trait.ontology def: "an upper lip having an inverted V- shape " [ncbi:Matthew Mailman_NCBI request] is_a: MT:0003769 ! lip morphology [Term] id: MT:0003784 name: lip vermillion border namespace: Trait.ontology def: "reduced thickness of the line between the lip and the facial skin around the mouth " [ncbi:Matthew Mailman_NCBI request] is_a: MT:0003769 ! lip morphology [Term] id: MT:0003785 name: lip mucosal nodules namespace: Trait.ontology def: "small mass of tissue or aggregation of cells in the mucosal tissue of the inner lip" [ncbi:Matthew Mailman_NCBI request] is_a: MT:0003769 ! lip morphology [Term] id: MT:0003786 name: onset of aging namespace: Trait.ontology def: "earlier than normal occurrence of the normal signs of aging" [J:97764, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0005372 ! life span/aging trait [Term] id: MT:0003788 name: interferon physiology namespace: Trait.ontology def: "impairment or increase of the cellular release of any of the cytokines produced by T cells, fibroblasts and other cells in response to a challenge by a foreign agents such as viruses, bacteria, parasites and tumor cells " [hdene:Howard Dene_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0005049 ! cytokine physiology [Term] id: MT:0003789 name: osteosarcoma namespace: Trait.ontology def: "malignant neoplasm derived from bone" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0002032 ! sarcoma [Term] id: MT:0003790 name: absent CD4+8- cells namespace: Trait.ontology def: "lack of the set of single-positive T cells that express CD4 on their surface" [acv:Alicia Valenzuela_Genetic Resources Curator, csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] is_a: MT:0002432 ! CD4+ T cell morphology/development [Term] id: MT:0003791 name: minor salivary gland morphology namespace: Trait.ontology def: "any structural malformations of the smaller, largely mucus-secreting, exocrine glands of the oral cavity, consisting of the labial, buccal, molar, lingual, and palatine glands" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0000613 ! salivary gland morphology [Term] id: MT:0003792 name: major salivary gland morphology namespace: Trait.ontology def: "any structural malformations of the three largest glands of the oral cavity that secrete most of the saliva, including the parotid, submandibular, and sublingual glands " [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0000613 ! salivary gland morphology [Term] id: MT:0003793 name: submandibular gland morphology namespace: Trait.ontology def: "any structural malformation of either of the large major salivary glands situated beneath the mandible" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0003792 ! major salivary gland morphology [Term] id: MT:0003794 name: onset of somite formation namespace: Trait.ontology def: "late onset of the induction and/or differentiation of the somites" [J:99723, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0001688 ! somite development [Term] id: MT:0003795 name: bone structure namespace: Trait.ontology def: "anomaly in the composite material or the layered arrangement of the bony endoskeleton of the body" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] subset: slim_cattle subset: slim_pig is_a: MT:0005508 ! skeleton morphology [Term] id: MT:0003796 name: cortical bone morphology namespace: Trait.ontology def: "structural anomaly of the superficial thin layer of compact bone" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0003797 ! compact bone morphology [Term] id: MT:0003797 name: compact bone morphology namespace: Trait.ontology def: "structural anomaly of the outer layers of solid, hard bone that covers spongy bone; consists of parallel osteons containing mineral deposits and interstitial lamellae" [hdene:Howard Dene_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal dense bone" EXACT [] synonym: "abnormal lamellar bone" EXACT [] is_a: MT:0003795 ! bone structure [Term] id: MT:0003798 name: Harderian gland pigmentation namespace: Trait.ontology def: "anomalous coloring of the sebaceous gland located behind the eyeball in the orbit that excretes fluid that facilitates movement of the third eyelid" [llw2:Linda Washburn_Mouse Genome Informatics Curator] is_a: MT:0001186 ! pigmentation trait [Term] id: MT:0003799 name: macrophage migration namespace: Trait.ontology def: "defect in the ability of macrophages to move up a chemotactic gradient" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0005495 ! macrophage recruitment [Term] id: MT:0003800 name: monodactyly namespace: Trait.ontology def: "having only one toe or digit on each extremity" [monikat:Monika Tomczuk_Mouse Genome Informatics Curator] synonym: "monodactylous" EXACT [] is_a: MT:0002110 ! digit morphology [Term] id: MT:0003801 name: histocompatibility locus namespace: Trait.ontology def: "deviation from the parental type of histocompatibility" [mberry:Melissa Berry_Genetics Resources Curator] synonym: "altered histocompatibility locus" EXACT [] is_a: MT:0001790 ! immune system physiology [Term] id: MT:0003802 name: class I histocompatibility locus namespace: Trait.ontology def: "deviation from the parental type of class I histocompatibility" [mberry:Melissa Berry_Genetics Resources Curator] is_a: MT:0003801 ! histocompatibility locus [Term] id: MT:0003803 name: class II histocompatibility locus namespace: Trait.ontology def: "deviation from the parental type of class II histocompatibility" [mberry:Melissa Berry_Genetics Resources Curator] is_a: MT:0003801 ! histocompatibility locus [Term] id: MT:0003804 name: minor histocompatibility locus namespace: Trait.ontology def: "deviation from the parental type of minor histocompatibility" [mberry:Melissa Berry_Genetics Resources Curator] is_a: MT:0003801 ! histocompatibility locus [Term] id: MT:0003805 name: histocompatibility-related locus namespace: Trait.ontology def: "deviation from the parental type of a histocompatibility-related locus" [mberry:Melissa Berry_Genetics Resources Curator] is_a: MT:0003801 ! histocompatibility locus [Term] id: MT:0003806 name: nucleotide metabolism namespace: Trait.ontology def: "impaired regulation of nucleotide levels in either production or breakdown of these structural components of nucleic acids" [MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0002121 ! metabolism [Term] id: MT:0003807 name: camptodactyly namespace: Trait.ontology def: "permanent flexion of one or more digits; contractures may also be seen in the wrists and at the elbows" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0002110 ! digit morphology [Term] id: MT:0003809 name: hair shaft morphology namespace: Trait.ontology alt_id: MT:0002854 def: "irregular or unusual structure of the cuticle, and/or cortex and/or medulla of a hair" [llw2:Linda Washburn_Mouse Genome Informatics Curator] synonym: "abnormal hair shaft" EXACT [] is_a: MT:0000367 ! coat/ hair morphology [Term] id: MT:0003810 name: hair cuticle morphology namespace: Trait.ontology def: "anomalies in the thin, smooth and glossy outer protective cell layer of hair shaft" [llw2:Linda Washburn_Mouse Genome Informatics Curator] is_a: MT:0003809 ! hair shaft morphology [Term] id: MT:0003811 name: hair cortex morphology namespace: Trait.ontology def: "anomalies in the spindle shaped cells of the hair shaft that contains keratin fibrils and matrix" [llw2:Linda Washburn_Mouse Genome Informatics Curator] is_a: MT:0003809 ! hair shaft morphology [Term] id: MT:0003812 name: hair medulla morphology namespace: Trait.ontology def: "anomalies of hair medullary cell formation and arrangement of the innermost core of the hair shaft " [llw2:Linda Washburn_Mouse Genome Informatics Curator] is_a: MT:0003809 ! hair shaft morphology [Term] id: MT:0003813 name: dermal papilla morphology namespace: Trait.ontology def: "abnormalities in this specialized group of mesenchymal cells necessary for initiation of follicle development" [llw2:Linda Washburn_Mouse Genome Informatics Curator] is_a: MT:0002076 ! hair follicle structure/orientation [Term] id: MT:0003815 name: hair number namespace: Trait.ontology def: "total number of hairs" [llw2:Linda Washburn_Mouse Genome Informatics Curator] subset: slim_pig synonym: "amount of hair" RELATED [] is_a: MT:0001510 ! coat appearance is_a: MT:0002073 ! hair growth [Term] id: MT:0003816 name: pituitary gland development namespace: Trait.ontology def: "malformation or incomplete differentiation of the compound gland suspended from the base of the hypothalamus, which secretes somatotropins, prolactin, TSH (thyroid-stimulating hormone), gonadotropins, adrenal corticotropin" [J:51160, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0000633 ! pituitary gland morphology [Term] id: MT:0003817 name: Rathke's pouch morphology namespace: Trait.ontology def: "malformation or incomplete differentiation of a pouch of ectoderm that grows out from the upper surface of the embryonic stomodeum and gives rise to the anterior and intermediate lobes of the pituitary gland" [J:51160, smb:Susan M. Bello_Mouse Genome Informatics Curator] synonym: "abnormal Rathke's pocket" EXACT [] is_a: MT:0003816 ! pituitary gland development [Term] id: MT:0003818 name: eye muscle development namespace: Trait.ontology def: "malformation or arrest of differentiation of the muscles of the eye" [J:51160, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0000733 ! muscle development is_a: MT:0001286 ! eye development [Term] id: MT:0003821 name: left ventricle diastolic pressure namespace: Trait.ontology def: "decrease in the pressure in the left ventricle between heart beats when the heart is relaxed" [RGD:cur "Rat Genome Database submission"] is_a: MT:0006263 ! diastolic blood pressure [Term] id: MT:0003822 name: left ventricle systolic pressure namespace: Trait.ontology def: "pressure in the left ventricle as the heart contracts and pumps blood into the arteries" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] is_a: MT:0006264 ! systolic blood pressure [Term] id: MT:0003824 name: left ventricular developed pressure namespace: Trait.ontology def: "difference between left ventricular systolic and diastolic pressures" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] is_a: MT:0000230 ! blood pressure [Term] id: MT:0003825 name: pillar cell morphology namespace: Trait.ontology def: "form, structure or number of the supporting cells that form the inner and outer walls of the tunnel in the organ of Corti " [monikat:Monika Tomczuk_Mouse Genome Informatics Curator] is_a: MT:0004300 ! organ of Corti supporting cell morphology [Term] id: MT:0003826 name: Mullerian duct morphology namespace: Trait.ontology def: "malformation of the transient embryonic tubes that empty into the cloaca and in the female develop into the oviducts, uterus, and vagina" [smb:Susan M. Bello_Mouse Genome Informatics Curator] synonym: "abnormal Muller duct morphology" EXACT [] is_a: MT:0003936 ! reproductive system development [Term] id: MT:0003827 name: Wolffian duct morphology namespace: Trait.ontology def: "malformation of the transient embryonic tubes that empty into the cloaca and degenerate in the male " [MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0003936 ! reproductive system development [Term] id: MT:0003828 name: pulmonary edema namespace: Trait.ontology def: "an accumulation of an excessive amount of watery fluid in the lung " [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, J:44108] is_a: MT:0001785 ! edema is_a: MT:0002133 ! respiratory system physiology [Term] id: MT:0003829 name: febrile response namespace: Trait.ontology def: "reduced or absent febrile response to exogenous or endogenous pyrogens" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, J:70534] is_a: MT:0001777 ! body temperature regulation [Term] id: MT:0003830 name: testis development namespace: Trait.ontology def: "abnormal morphogenesis of the male reproductive gland containing the germ cells" [J:100020, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0001146 ! testis morphology is_a: MT:0003936 ! reproductive system development [Term] id: MT:0003831 name: prostate tumor namespace: Trait.ontology def: "presence of abnormal rapidly proliferating cells in the prostate, usually in the form of a distinct mass" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0002019 ! tumor incidence [Term] id: MT:0003833 name: number of satellite cells namespace: Trait.ontology def: "less than the normal number of unfused cells in muscle that play a role in muscle regeneration" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0000759 ! skeletal muscle morphology [Term] id: MT:0003834 name: adrenergic chromaffin cell morphology namespace: Trait.ontology def: "malformation of the cells responsible for epinephrine and norepinephrine secretion" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0000639 ! adrenal gland morphology [Term] id: MT:0003838 name: milk ejection namespace: Trait.ontology def: "impaired milk ejection reflex in response to suckling during lactation" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, J:36926] is_a: MT:0001882 ! lactation [Term] id: MT:0003839 name: insulin clearance namespace: Trait.ontology def: "increase or decrease in the rate at which insulin is removed from the blood stream" [J:99786, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0002078 ! glucose homeostasis [Term] id: MT:0003840 name: coronal suture morphology namespace: Trait.ontology def: "malformation of the articulation between the parietal bones and the frontal bone" [smb:Susan M. Bello_Mouse Genome Informatics Curator, Taber's Cyclopedic Medical Dictionary_19th edition:ISBN N 0-8036-0655-99] synonym: "abnormal frontoparietal suture morphology" EXACT [] is_a: MT:0002835 ! cranial suture morphology [Term] id: MT:0003841 name: lambdoidal suture morphology namespace: Trait.ontology def: "malformation of the articulation of the parietal bones and the occipital bone" [smb:Susan M. Bello_Mouse Genome Informatics Curator, Taber's Cyclopedic Medical Dictionary_19th edition:ISBN N 0-8036-0655-99] synonym: "abnormal occipital suture morphology" EXACT [] synonym: "abnormal occipitoparietal suture morphology" EXACT [] is_a: MT:0002835 ! cranial suture morphology [Term] id: MT:0003842 name: metopic suture morphology namespace: Trait.ontology def: "malformation of the articulation of the frontal bone from the sagittal suture to the root of the nose" [smb:Susan M. Bello_Mouse Genome Informatics Curator, Taber's Cyclopedic Medical Dictionary_19th edition:ISBN N 0-8036-0655-99] synonym: "abnormal frontal suture morphology" EXACT [] synonym: "abnormal mediofrontal suture morphology" EXACT [] is_a: MT:0002835 ! cranial suture morphology [Term] id: MT:0003843 name: sagittal suture morphology namespace: Trait.ontology def: "malformation of the articulation between the parietal bones" [smb:Susan M. Bello_Mouse Genome Informatics Curator, Taber's Cyclopedic Medical Dictionary_19th edition:ISBN N 0-8036-0655-99] synonym: "abnormal interparietal suture morphology" EXACT [] synonym: "abnormal longitudinal suture morphology" EXACT [] synonym: "abnormal parietal suture morphology" EXACT [] is_a: MT:0002835 ! cranial suture morphology [Term] id: MT:0003844 name: squamo-parietal suture morphology namespace: Trait.ontology def: "malformation of the articulation of the squamous portion of the temporal bones with the parietal bones" [smb:Susan M. Bello_Mouse Genome Informatics Curator, Taber's Cyclopedic Medical Dictionary_19th edition:ISBN N 0-8036-0655-99] is_a: MT:0002835 ! cranial suture morphology [Term] id: MT:0003845 name: decidualization namespace: Trait.ontology def: "disrupted proliferation, differentiation or transformation of endometrial stromal cells into decidual cells in the maternal uterus following embryo implantation" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, J:43609, J:48920] synonym: "defective decidualization" EXACT [] is_a: MT:0004014 ! uterine environment [Term] id: MT:0003846 name: matted coat namespace: Trait.ontology def: "coat hairs sticks together to form clumps and does not lie flat" [llw2:Linda Washburn_Mouse Genome Informatics Curator] is_a: MT:0001510 ! coat appearance is_a: MT:0002074 ! hair texture [Term] id: MT:0003847 name: lens bow organization namespace: Trait.ontology def: "derangement of the area where the lens epithelium pushes into the lens proper and forms new lens fibers" [brs:Beverly Richards-Smith_Mouse Genome Informatics Curator] is_a: MT:0001303 ! lens morphology [Term] id: MT:0003848 name: brittle hair namespace: Trait.ontology def: "hair is susceptible to breakage " [llw2:Linda Washburn_Mouse Genome Informatics Curator] is_a: MT:0002074 ! hair texture [Term] id: MT:0003849 name: greasy coat namespace: Trait.ontology def: "fur is oily in appearance or texture" [llw2:Linda Washburn_Mouse Genome Informatics Curator] is_a: MT:0001510 ! coat appearance [Term] id: MT:0003850 name: thymocyte activation/response namespace: Trait.ontology def: "anomaly in the process of producing activated thymocytes from naive thymocytes" [mberry:Melissa Berry_Genetics Resources Curator] is_a: MT:0001819 ! immune cell physiology [Term] id: MT:0003851 name: skeletal muscle interstitial fibrosis namespace: Trait.ontology def: "formation of fibrous tissue within the interstices of skeletal muscle as a result of repair or a reactive process" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000759 ! skeletal muscle morphology [Term] id: MT:0003852 name: skeletal muscle necrosis namespace: Trait.ontology def: "pathological cell death in the skeletal muscle, usually due to irreversible damage" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000759 ! skeletal muscle morphology [Term] id: MT:0003853 name: skin moisture level namespace: Trait.ontology def: "skin characterized by the lack of natural or normal moisture" [monikat:Monika Tomczuk_Mouse Genome Informatics Curator] is_a: MT:0001191 ! skin condition [Term] id: MT:0003854 name: forelimb stylopod morphology namespace: Trait.ontology def: "malformation of the proximal element of the developing forelimb that will give rise to the humerus" [PMID:12560810] is_a: MT:0006279 ! limb development [Term] id: MT:0003855 name: forelimb zeugopod morphology namespace: Trait.ontology def: "malformation of the distal elements of the developing forelimb that will give rise to the radius and ulna" [PMID:12560810] is_a: MT:0006279 ! limb development [Term] id: MT:0003856 name: hindlimb stylopod morphology namespace: Trait.ontology def: "malformation of the proximal element of the developing hindlimb that will give rise to the femur" [PMID:12560810] is_a: MT:0006279 ! limb development [Term] id: MT:0003857 name: hindlimb zeugopod morphology namespace: Trait.ontology def: "malformation of the distal elements of the developing hindlimb that will give rise to the tibia and fibula" [PMID:12560810] is_a: MT:0006279 ! limb development [Term] id: MT:0003859 name: Harderian gland physiology namespace: Trait.ontology def: "anomalous function of the sebaceous gland located behind the eyeball in the orbit that secretes lipids, porphyrins, and indoles such as melatonin" [J:44727, monikat:Monika Tomczuk_Mouse Genome Informatics Curator] is_a: MT:0002164 ! gland physiology [Term] id: MT:0003860 name: carbon dioxide level namespace: Trait.ontology def: "anomalous concentration of CO2 in the blood, alveoli or other tissues resulting in the increased pressure of this component of body gases" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0003948 ! gas homeostasis [Term] id: MT:0003861 name: nervous system development namespace: Trait.ontology def: "impaired or altered growth of the components of the nervous system" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0003632 ! nervous system morphology [Term] id: MT:0003864 name: midbrain development namespace: Trait.ontology def: "anomaly in the formation of or the patterning of the part of the brainstem developing from the middle of the three primary cerebral vesicles of the embryo" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000913 ! brain development [Term] id: MT:0003865 name: lymph node inflammation namespace: Trait.ontology def: "local accumulation of fluid, plasma proteins, and leukocytes in the lymph nodes" [monikat:Monika Tomczuk_Mouse Genome Informatics Curator] synonym: "lymphadenitis" EXACT [] is_a: MT:0001846 ! tissue specific inflammatory response [Term] id: MT:0003866 name: defecation namespace: Trait.ontology def: "anomaly in the production and excretion of feces" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0001663 ! digestive system physiology [Term] id: MT:0003868 name: feces composition namespace: Trait.ontology def: "increase or decrease in the amount of compounds normally found in the feces (fat, protein etc) or presence of material not normally seen in the feces" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0001663 ! digestive system physiology [Term] id: MT:0003869 name: ectopic cartilage namespace: Trait.ontology def: "positional abnormality of cartilage" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0000163 ! cartilage morphology [Term] id: MT:0003871 name: myelin sheath morphology namespace: Trait.ontology def: "malformation of the insulating envelope that surrounds nerve fibers or axons" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0005404 ! axon morphology [Term] id: MT:0003875 name: hair follicle regression namespace: Trait.ontology def: "abnormal length of time for the onset of catagen phase of the cyclic transformation of the hair follicle" [monikat:Monika Tomczuk_Mouse Genome Informatics Curator] is_a: MT:0002076 ! hair follicle structure/orientation [Term] id: MT:0003876 name: cerebral function namespace: Trait.ontology def: "anomalous activity of the thin layer of gray matter on the surface of the cerebral hemisphere that develops from the telencephalon and folds into gyri that is responsible for higher mental functions" [MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0003633 ! nervous system physiology [Term] id: MT:0003877 name: serotonergic neuron morphology namespace: Trait.ontology def: "malformation or absence of the neurons that secrete serotonin" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, J:54240] is_a: MT:0002882 ! neuron [Term] id: MT:0003878 name: ear physiology namespace: Trait.ontology def: "functions and processes of the ear" [J:100987, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0005377 ! hearing/vestibular/ear trait [Term] id: MT:0003879 name: hair cell physiology namespace: Trait.ontology def: "function of the sensory epithelial cells of the inner ear" [J:100987, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0003878 ! ear physiology is_a: MT:0005423 ! somatic nervous system physiology [Term] id: MT:0003880 name: central pattern generator function namespace: Trait.ontology def: "anomalous function of the neural networks that produce rhythmic patterned output without sensory input and underlie rhythmic motor patterns" [J:101019, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0003633 ! nervous system physiology [Term] id: MT:0003881 name: nephron morphology namespace: Trait.ontology def: "malformation of the filtering unit of the kidney that includes the renal corpuscle, proximal and distal convoluted tubules, and loop of Henle" [J:71588, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0002135 ! kidney morphology [Term] id: MT:0003882 name: pulse pressure namespace: Trait.ontology def: "difference between systolic and diastolic blood pressure" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] is_a: MT:0000230 ! blood pressure [Term] id: MT:0003883 name: stomach size namespace: Trait.ontology def: "increased size of the stomach" [monikat:Monika Tomczuk_Mouse Genome Informatics Curator] is_a: MT:0000470 ! stomach morphology [Term] id: MT:0003884 name: macrophage count namespace: Trait.ontology def: "fewer than the normal numbers of macrophages" [acv:Alicia Valenzuela_Genetic Resources Curator] is_a: MT:0000223 ! monocyte count is_a: MT:0002446 ! macrophage morphology/development [Term] id: MT:0003885 name: rostro-caudal body axis extension namespace: Trait.ontology def: "anomaly in or failure of the long (rostral-caudal) axis of the body to elongate normally once patterning has been established" [brs:Beverly Richards-Smith_Mouse Genome Informatics Curator] is_a: MT:0002085 ! embryonic tissue morphology [Term] id: MT:0003886 name: embryonic epiblast morphology namespace: Trait.ontology def: "anomaly in the development/organization of the tissue that gives rise to the ectoderm, endoderm and mesoderm of the embryo proper" [brs:Beverly Richards-Smith_Mouse Genome Informatics Curator] is_a: MT:0002085 ! embryonic tissue morphology [Term] id: MT:0003887 name: hepatocyte apoptosis namespace: Trait.ontology def: "increase in the number of hepatocytes undergoing programmed cell death" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0000607 ! hepatocyte morphology [Term] id: MT:0003890 name: embryonic-extraembryonic boundary morphology namespace: Trait.ontology def: "anomaly in the normal development /maintenance of the connection between the embryo proper and extraembryonic tissues" [brs:Beverly Richards-Smith_Mouse Genome Informatics Curator] is_a: MT:0001672 ! embryogenesis/ development [Term] id: MT:0003892 name: gastric gland morphology namespace: Trait.ontology def: "anomaly of any of the branched tubular glands in the mucosa of the fundus and body of the stomach that contain parietal cells that secrete hydrochloric acid and zymogenic cells that produce pepsin " [monikat:Monika Tomczuk_Mouse Genome Informatics Curator] synonym: "abnormal fundus gland" EXACT [] synonym: "abnormal gastric follicle" EXACT [] is_a: MT:0005209 ! gastric mucosa morphology [Term] id: MT:0003893 name: hepatocyte proliferation namespace: Trait.ontology def: "anomalous growth and reproduction of hepatocyte cells of the liver" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0000607 ! hepatocyte morphology [Term] id: MT:0003894 name: Purkinje cell innervation namespace: Trait.ontology def: "malformation or absence of the supply of nerve fibers that connect to the Purkinje cells" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0000877 ! Purkinje cell morphology is_a: MT:0002184 ! innervation [Term] id: MT:0003902 name: cell mass namespace: Trait.ontology def: "anomaly in the total physical bulk or volume of a cell compared to the normal state" [RGD:Rat Genome Database submission] is_a: MT:0000358 ! cell content/ morphology [Term] id: MT:0003905 name: aorta elastin content namespace: Trait.ontology def: "physical amount of elastin in the aorta" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] synonym: "aortic elastin content" RELATED [] relationship: part_of MT:0007048 ! aorta elastic tissue composition [Term] id: MT:0003919 name: lymph node cellularity namespace: Trait.ontology def: "anomaly in the cellular make up of the lymph nodes" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0002222 ! lymph organ cellularity is_a: MT:0002339 ! lymph node morphology [Term] id: MT:0003920 name: right ventricle morphology namespace: Trait.ontology def: "any measurable or observable characteristic related to the shape, structure, color or pattern of the right lower chamber of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] subset: slim_chkn synonym: "right ventricular morphology" RELATED [] xref: MP:0003920 is_a: MT:0005294 ! heart ventricle morphology [Term] id: MT:0003921 name: left ventricle morphology namespace: Trait.ontology def: "any measurable or observable characteristic related to the shape, structure, color or pattern of the left lower chamber of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] synonym: "left ventricular morphology" RELATED [] xref: MP:0003921 is_a: MT:0005294 ! heart ventricle morphology [Term] id: MT:0003922 name: right atrium integrity namespace: Trait.ontology def: "any measurable characteristic pertaining to the the structural completeness or structural soundness of the right upper chamber of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator", RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] relationship: part_of MT:0000019 ! right atrium morphology relationship: part_of MT:0000053 ! heart integrity [Term] id: MT:0003923 name: left atrium integrity namespace: Trait.ontology def: "any measurable characteristic pertaining to the the structural completeness or structural soundness of the left upper chamber of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator", RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] synonym: "left atrial integrity" RELATED [] relationship: part_of MT:0000020 ! left atrium morphology relationship: part_of MT:0000053 ! heart integrity [Term] id: MT:0003924 name: herniated diaphragm namespace: Trait.ontology def: "protrusion of abdominal contents into the thoracic cavity through the diaphragm" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0002279 ! diaphragm morphology [Term] id: MT:0003925 name: cellular glucose import namespace: Trait.ontology def: "anomaly in the ability of a cell to take in glucose from the environment" [RGD:Rat Genome Database submission] is_a: MT:0005621 ! cell physiology [Term] id: MT:0003929 name: heart rate regularity namespace: Trait.ontology def: "consistency of beat-to-beat intervals of the heart" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] synonym: "heart rate variablility" RELATED [] is_a: MT:0001629 ! heart rate [Term] id: MT:0003930 name: tooth hard tissue morphology namespace: Trait.ontology def: "defects in the hard portion of the tooth surrounding the pulp, including the dentin, enamel and the cementum on the root" [MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0002100 ! tooth morphology [Term] id: MT:0003932 name: molar crown morphology namespace: Trait.ontology def: "defects in the upper part of the molar, which is normally covered with enamel " [MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0002689 ! molar morphology [Term] id: MT:0003933 name: cementum morphology namespace: Trait.ontology def: "defects in the bonelike rigid connective tissue covering the root of a tooth" [MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0003930 ! tooth hard tissue morphology [Term] id: MT:0003934 name: pancreas development namespace: Trait.ontology def: "anomaly in the formation of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0001944 ! pancreas morphology is_a: MT:0003119 ! digestive system development [Term] id: MT:0003935 name: craniofacial development namespace: Trait.ontology def: "anomaly in the process of forming the face and/or cranium" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0000428 ! craniofacial morphology [Term] id: MT:0003936 name: reproductive system development namespace: Trait.ontology def: "developmental anomaly of any of the organs involved in the reproductive system" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0002160 ! reproductive system morphology [Term] id: MT:0003937 name: limbs/digits/tail development namespace: Trait.ontology def: "anomaly of the formation of the digits, autopod, limbs, or tail" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0000545 ! limbs/digits/tail morphology [Term] id: MT:0003938 name: ear development namespace: Trait.ontology def: "development of any of the structures involved in the ear or vestibular system" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0002102 ! ear morphology [Term] id: MT:0003939 name: myotome morphology namespace: Trait.ontology def: "structural anomaly in the mesoderm that is derived from the somite that is fated to become the musculature" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0000733 ! muscle development [Term] id: MT:0003940 name: dermatome morphology namespace: Trait.ontology def: "anomaly in the mesoderm that is derived from the somite that is fated to become the dermis" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0003941 ! skin development [Term] id: MT:0003941 name: skin development namespace: Trait.ontology def: "anomaly in the formation of the membranous protective covering of the body" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0002096 ! skin condition/ morphology [Term] id: MT:0003942 name: urinary system development namespace: Trait.ontology is_a: MT:0000516 ! urinary system morphology [Term] id: MT:0003943 name: liver/biliary system development namespace: Trait.ontology def: "developmental anomaly of any of the tissues of the liver or biliary system" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0002138 ! liver/biliary system morphology [Term] id: MT:0003944 name: T cell subpopulation ratio namespace: Trait.ontology def: "deviation from the standard ratios of T cell subpopulations (e.g. double positive to single positive ratio) compared to control samples" [mberry:Melissa Berry_Genetics Resources Curator] is_a: MT:0000717 ! lymphocyte number [Term] id: MT:0003945 name: lymphocyte physiology namespace: Trait.ontology def: "abnormal function of any of the white blood cells that includes B cells, T cells, and NK cells" [monikat:Monika Tomczuk_Mouse Genome Informatics Curator] subset: slim_pig is_a: MT:0002442 ! leukocyte physiology [Term] id: MT:0003946 name: renal necrosis namespace: Trait.ontology def: "pathological cell death in the kidney, usually due to irreversible damage" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] synonym: "kidney necrosis" EXACT [] is_a: MT:0002135 ! kidney morphology [Term] id: MT:0003947 name: cholesterol level namespace: Trait.ontology def: "anomaly in the concentration in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] subset: slim_chkn subset: slim_pig is_a: MT:0001547 ! lipid level is_a: MT:0005278 ! cholesterol homeostasis [Term] id: MT:0003948 name: gas homeostasis namespace: Trait.ontology def: "anomaly in the state of equilibrium in the body of gaseous elements in animal tissues or blood" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0001764 ! homeostasis [Term] id: MT:0003949 name: circulating lipid level namespace: Trait.ontology def: "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the blood" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] subset: slim_chkn is_a: MT:0000179 ! blood chemistry is_a: MT:0001547 ! lipid level [Term] id: MT:0003950 name: plasma membrane morphology namespace: Trait.ontology def: "anomalous structure of the semi-permeable membrane that encloses the cytoplasm of a cell" [monikat:Monika Tomczuk_Mouse Genome Informatics Curator] synonym: "abnormal cell membrane morphology" EXACT [] is_a: MT:0000358 ! cell content/ morphology [Term] id: MT:0003951 name: copper homeostasis namespace: Trait.ontology def: "anomaly in the state of equilibrium in the body with respect to this metallic element that normally occurs in a number of proteins including amine oxidases and chaperone proteins" [MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0005636 ! mineral homeostasis [Term] id: MT:0003952 name: copper level namespace: Trait.ontology def: "anomaly in the concentration in the body with respect to this metallic element that normally occurs in a number of proteins including amine oxidases and chaperone proteins" [MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0000192 ! mineral level is_a: MT:0003951 ! copper homeostasis [Term] id: MT:0003953 name: hormone level namespace: Trait.ontology def: "aberrant tissue or circulating concentration of any substance, usually a peptide or steroid, that has a specific metabolic regulatory effect on the activity or behavior of cells expressing a receptor for the hormone" [MeSH:National Library of Medicine_Medical Subject Headings] subset: slim_cattle subset: slim_chkn subset: slim_pig is_a: MT:0001764 ! homeostasis [Term] id: MT:0003954 name: Reichert's membrane morphology namespace: Trait.ontology def: "aberrant structure of the extraembryonic basement membrane that forms on the inner surface of the trophectoderm beginning at E6.0 and is secreted by the distal endoderm; required for the maternofetal exchange of nutrients and is important for the postgastrulation development" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0002086 ! extraembryonic tissue morphology [Term] id: MT:0003955 name: ultimobranchial body morphology namespace: Trait.ontology def: "a sac-like structure emanating from the caudal-most branchial pouch of the embryo; develops into the lateral portion of the thyroid that produced calcitonin in higher vertebrates" [hdene:Howard Dene_Mouse Genome Informatics Curator] is_a: MT:0003421 ! thyroid gland development is_a: MT:0006031 ! branchial pouch morphology [Term] id: MT:0003956 name: body size namespace: Trait.ontology def: "anomaly in the average body weight, height and/or length of an organism compared to controls" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] subset: slim_cattle subset: slim_pig is_a: MT:0002089 ! postnatal growth/weight/body size [Term] id: MT:0003957 name: nitric oxide homeostasis namespace: Trait.ontology def: "anomaly in the state of equilibrium in the body of nitric oxide, a free radical gas and a potent vasodilator" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] synonym: "abnormal endothelium derived relaxation factor homeostasis" EXACT [] is_a: MT:0003948 ! gas homeostasis [Term] id: MT:0003959 name: lean body mass namespace: Trait.ontology def: "aberrant fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda_Mouse Genome Informatics Curator] is_a: MT:0002089 ! postnatal growth/weight/body size [Term] id: MT:0003962 name: adrenaline level namespace: Trait.ontology alt_id: MT:0003835 def: "aberrant concentration in the blood or tissues of this catecholamine hormone that stimulates the adrenergic receptors and that causes systemic vasoconstriction and gastrointestinal relaxation, stimulates the heart, and dilates bronchi and cerebral vessels" [pvb:Pierre Vanden Borre_Mouse Genome Informatics Curator] synonym: "abnormal adrenal adrenaline level" EXACT [] synonym: "abnormal adrenal epinephrine level" EXACT [] is_a: MT:0003953 ! hormone level [Term] id: MT:0003963 name: corticosterone level namespace: Trait.ontology alt_id: MT:0003837 def: "anomalous blood or tissue concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [smb:Susan M. Bello_Mouse Genome Informatics Curator] subset: slim_chkn synonym: "abnormal adrenal corticosterone level" EXACT [] is_a: ID:0000671 ! glucocorticoid level [Term] id: MT:0003964 name: noradrenaline level namespace: Trait.ontology alt_id: MT:0003836 def: "aberrant concentration of this precursor of epinephrine that is a widespread central and autonomic neurotransmitter" [smb:Susan M. Bello_Mouse Genome Informatics Curator] synonym: "abnormal adrenal noradrenaline level" EXACT [] synonym: "abnormal adrenal norepinephrine level" EXACT [] is_a: MT:0003953 ! hormone level [Term] id: MT:0003965 name: pituitary hormone level namespace: Trait.ontology alt_id: MT:0005125 def: "aberration in the blood or tissue concentration of any of the hormones secreted by the pituitary" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] subset: slim_cattle subset: slim_chkn subset: slim_pig is_a: MT:0003953 ! hormone level [Term] id: MT:0003966 name: adrenocorticotropin level namespace: Trait.ontology def: "anomalous concentration of the pituitary hormone that stimulates the secretion of adrenal cortical steroids and induces growth of the adrenal cortex" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] subset: slim_pig is_a: MT:0003965 ! pituitary hormone level [Term] id: MT:0003967 name: follicle stimulating hormone level namespace: Trait.ontology def: "anomalous concentration of the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] subset: slim_cattle subset: slim_chkn subset: slim_pig is_a: MT:0003965 ! pituitary hormone level [Term] id: MT:0003968 name: growth hormone level namespace: Trait.ontology def: "anomalous concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0003965 ! pituitary hormone level [Term] id: MT:0003969 name: luteinizing hormone level namespace: Trait.ontology def: "aberrant levels in the bloodstream of LH, the hormone that regulates steroid production by the interstitial cells of the testis and the ovary" [MeSH:National Library of Medicine_Medical Subject Headings, pvb:Pierre Vanden Borre_Mouse Genome Informatics Curator] subset: slim_cattle subset: slim_chkn subset: slim_pig synonym: "abnormal LH level" RELATED [] synonym: "abnormal lutropin level" RELATED [] is_a: MT:0003965 ! pituitary hormone level [Term] id: MT:0003970 name: prolactin level namespace: Trait.ontology def: "anomalous concentration of the hormone that stimulates milk secretion " [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0003965 ! pituitary hormone level [Term] id: MT:0003971 name: thyroid-stimulating hormone level namespace: Trait.ontology def: "anomalous concentration of the hormone that stimulates the growth and function of the thyroid gland" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] subset: slim_pig is_a: MT:0003965 ! pituitary hormone level [Term] id: MT:0003974 name: endocardium morphology namespace: Trait.ontology def: "any measurable or observable characteristic related to the shape, structure, color or pattern of the thin serous membrane, primarily composed of endothelial tissue, that lines the interior of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator", RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] relationship: part_of MT:0000266 ! cardiac morphology [Term] id: MT:0003976 name: circulating VLDL triglyceride level namespace: Trait.ontology def: "lower than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [brs:Beverly Richards-Smith_Mouse Genome Informatics Curator] is_a: MT:0002644 ! circulating triglyceride level [Term] id: MT:0003977 name: circulating carnitine level namespace: Trait.ontology def: "aberrant concentration in the blood of carnitine, a quaternary ammonium amino acid derivative involved in transport of fatty acids across the mitochondrial membrane" [brs:Beverly Richards-Smith_Mouse Genome Informatics Curator] is_a: MT:0000179 ! blood chemistry [Term] id: MT:0003984 name: embryonic growth rate namespace: Trait.ontology alt_id: MT:0001692 def: "slow or limited development during the embryonic period (sensu Mus: up to E14, or the completion of organogenesis)" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] synonym: "delayed embryonic development" EXACT [] is_a: MT:0001672 ! embryogenesis/ development is_a: MT:0002088 ! embryonic growth/weight/body size [Term] id: MT:0003985 name: renal fibrosis namespace: Trait.ontology def: "formation of fibrous tissue in the kidney as a result of repair or a reactive process" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0002135 ! kidney morphology [Term] id: MT:0003986 name: cochlear ganglion size namespace: Trait.ontology def: "reduced size of the cochlear ganglion or of the sensory neuron cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain and resides on the cochlear part of the vestibulocochlear nerve (eighth cranial nerve)" [monikat:Monika Tomczuk_Mouse Genome Informatics Curator] is_a: MT:0002855 ! cochlear ganglion morphology [Term] id: MT:0003987 name: vestibular ganglion size namespace: Trait.ontology def: "reduced size of the vestibular ganglion or of the sensory neuron cell bodies associated with the eighth cranial nerve" [monikat:Monika Tomczuk_Mouse Genome Informatics Curator] is_a: MT:0002856 ! vestibular ganglion morphology [Term] id: MT:0003989 name: barrel cortex morphology namespace: Trait.ontology def: "structure of the discrete functional units of the somatosensory cortex that processes tactile information derived from the vibrissae" [monikat:Monika Tomczuk_Mouse Genome Informatics Curator] is_a: MT:0000860 ! primary somatosensory cortex morphology [Term] id: MT:0003993 name: ventral spinal root morphology namespace: Trait.ontology def: "any anomaly, deformity, or malformation of the anterior bundle of nerves emerging from the spinal cord to join with the posterior/dorsal nerve bundle at each spinal cord segment to form one of the 31 paired peripheral nerves" [brs:Beverly Richards-Smith_Mouse Genome Informatics Curator] is_a: MT:0001077 ! spinal nerve morphology [Term] id: MT:0003994 name: dorsal spinal root morphology namespace: Trait.ontology def: "any anomaly, deformity, or malformation of the posterior bundle of nerves emerging from the spinal cord to join with the anterior/ventral nerve bundle at each spinal cord segment to form one of the 31 paired peripheral nerves" [brs:Beverly Richards-Smith_Mouse Genome Informatics Curator] is_a: MT:0001077 ! spinal nerve morphology [Term] id: MT:0003995 name: uterine artery integrity namespace: Trait.ontology def: "any measurable characteristic pertaining to the the structural completeness or structural soundness of the branch of the internal iliac artery that supplies the uterus and the upper part of the vagina" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] is_a: MT:0001120 ! uterus morphology is_a: MT:0003410 ! artery integrity [Term] id: MT:0004002 name: jejunum morphology namespace: Trait.ontology def: "malformation of the portion of the small intestine that extends from the duodenum to the ileum" [monikat:Monika Tomczuk_Mouse Genome Informatics Curator] is_a: MT:0000496 ! small intestine morphology [Term] id: MT:0004003 name: blood vessel endothelial cell function namespace: Trait.ontology def: "function of the cells that line the vasculature" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] synonym: "vascular endothelial cell fundtion" RELATED [] is_a: MT:0000249 ! blood vessel physiology [Term] id: MT:0004005 name: intestinal smooth muscle contractility namespace: Trait.ontology def: "inability or reduced ability of intestinal smooth muscle to shorten or to develop increased tension" [monikat:Monika Tomczuk_Mouse Genome Informatics Curator] is_a: MT:0000740 ! smooth muscle contractility [Term] id: MT:0004006 name: jejunal smooth muscle contractility namespace: Trait.ontology def: "inability or reduced ability of the jejunal smooth muscle to shorter or to develop increased tension" [monikat:Monika Tomczuk_Mouse Genome Informatics Curator] is_a: MT:0004005 ! intestinal smooth muscle contractility [Term] id: MT:0004007 name: lung blood vessel morphology namespace: Trait.ontology def: "any measurable or observable characteristic related to the shape, structure, color or pattern of the blood vessels of the lung" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] synonym: "lung vascular morphology" RELATED [] synonym: "pulmonary vasculature" RELATED [] xref: MP:0004007 is_a: MT:0001175 ! lung morphology is_a: MT:0001614 ! blood vessel morphology [Term] id: MT:0004008 name: GABA receptor currents namespace: Trait.ontology def: "change in the measured amplitude or duration of response to stimulation of GABA receptors" [smb:Susan M. Bello_Mouse Genome Informatics Curator] synonym: "abnormal gamma-amino-n-butyric acid receptor currents" EXACT [] is_a: MT:0002206 ! CNS synaptic transmission [Term] id: MT:0004009 name: diastolic filling velocity namespace: Trait.ontology def: "rate of fluid inflow to the heart during diastole; usually measured in the left ventricle" [RGD:cur "Rat Genome Database submission"] is_a: MT:0002128 ! blood circulation [Term] id: MT:0004014 name: uterine environment namespace: Trait.ontology def: "anomaly or inability of the uterus to support embryonic development" [llw2:Linda Washburn_Mouse Genome Informatics Curator] is_a: MT:0003699 ! female reproductive system physiology [Term] id: MT:0004015 name: oviduct environment namespace: Trait.ontology def: "anomaly or inability of the oviduct to support egg viability" [llw2:Linda Washburn_Mouse Genome Informatics Curator] is_a: MT:0003699 ! female reproductive system physiology [Term] id: MT:0004016 name: bone mass namespace: Trait.ontology def: "a reduction in the total amount of bone tissue contained in the skeleton" [monikat:Monika Tomczuk_Mouse Genome Informatics Curator] is_a: MT:0003795 ! bone structure [Term] id: MT:0004017 name: duplex kidney namespace: Trait.ontology def: "a kidney that is split into two separate collecting systems; there may be a duplex ureter or a single ureter; may present unilaterally or bilaterally" [rbabiuk:Randall Babiuk_Mouse Genome Informatics Curator] is_a: MT:0002135 ! kidney morphology [Term] id: MT:0004018 name: galactose homeostasis namespace: Trait.ontology def: "anomaly in the state of equilibrium or processing in the body with respect to galactose in the fluids and tissues" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0001764 ! homeostasis [Term] id: MT:0004019 name: vitamin homeostasis namespace: Trait.ontology def: "anomaly in the state of equilibrium in the body of organic substances found in food and are not synthesized by the body and are necessary in trace amounts for normal metabolic function" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0001764 ! homeostasis [Term] id: MT:0004020 name: amniotic fluid volume namespace: Trait.ontology def: "abnormally high amniotic fluid volume; may result from maternal diabetes, chromosomal abnormalities or other congenital abnormalities" [monikat:Monika Tomczuk_Mouse Genome Informatics Curator] is_a: MT:0001784 ! fluid regulation [Term] id: MT:0004021 name: rod electrophysiology namespace: Trait.ontology def: "anomaly in the function of dark adapted vision mediated by the rods" [smb:Susan M. Bello_Mouse Genome Informatics Curator] synonym: "abnormal scotopic response" EXACT [] is_a: MT:0005551 ! eye electrophysiology [Term] id: MT:0004022 name: cone electrophysiology namespace: Trait.ontology def: "anomaly in the function of light adapted vision mediated by the cones" [smb:Susan M. Bello_Mouse Genome Informatics Curator] synonym: "abnormal photopic response" EXACT [] is_a: MT:0005551 ! eye electrophysiology [Term] id: MT:0004023 name: chromosome number namespace: Trait.ontology def: "chromosome count is other than the expected diploid chromosome number" [llw2:Linda Washburn_Mouse Genome Informatics Curator] is_a: MT:0003111 ! nucleus morphology [Term] id: MT:0004024 name: aneuploidy namespace: Trait.ontology def: "chromosome count is not an exact multiple of the haploid number " [llw2:Linda Washburn_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0004023 ! chromosome number [Term] id: MT:0004025 name: polyploidy namespace: Trait.ontology def: "more than two chromosome sets are present" [llw2:Linda Washburn_Mouse Genome Informatics Curator] is_a: MT:0004023 ! chromosome number [Term] id: MT:0004026 name: monosomy namespace: Trait.ontology def: "one chromosome missing from an otherwise diploid chromosome set" [llw2:Linda Washburn_Mouse Genome Informatics Curator] is_a: MT:0004024 ! aneuploidy [Term] id: MT:0004027 name: trisomy namespace: Trait.ontology def: "presence of an extra chromosome in an otherwise diploid chromosome set" [llw2:Linda Washburn_Mouse Genome Informatics Curator] is_a: MT:0004024 ! aneuploidy [Term] id: MT:0004028 name: chromosome breakage namespace: Trait.ontology alt_id: MT:0002008 def: "chromosome instability in the from of increased frequency of spontaneous breakage with or without rearrangements" [llw2:Linda Washburn_Mouse Genome Informatics Curator] synonym: "chromosomal instability" EXACT [] is_a: MT:0003111 ! nucleus morphology [Term] id: MT:0004029 name: spontaneous chromosome breakage namespace: Trait.ontology def: "chromosome breakage due to inherent instability of chromosomes" [llw2:Linda Washburn_Mouse Genome Informatics Curator] is_a: MT:0004028 ! chromosome breakage [Term] id: MT:0004030 name: induced chromosome breakage namespace: Trait.ontology def: "chromosome breakage following treatment with a DNA-damaging agent " [llw2:Linda Washburn_Mouse Genome Informatics Curator] is_a: MT:0004028 ! chromosome breakage [Term] id: MT:0004031 name: insulitis namespace: Trait.ontology def: "a histological change in the islets of Langerhans characterized by edema and the infiltration of small numbers of white blood cells" [rbabiuk:Randall Babiuk_Mouse Genome Informatics Curator] is_a: MT:0001869 ! pancreas inflammation [Term] id: MT:0004032 name: interventricular groove morphology namespace: Trait.ontology def: "any measurable or observable characteristic related to the shape, structure, color or pattern of the indentation dividing the two ventricles, comprised of the sulcus interventricularis anterior and the sulcus interventricularis posterior" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] synonym: "interventricular sulcus morphology" EXACT [] relationship: part_of MT:0000266 ! cardiac morphology [Term] id: MT:0004034 name: belly blaze namespace: Trait.ontology def: "the appearance of a stripe or zigzag of white fur on the ventrum" [llw2:Linda Washburn_Mouse Genome Informatics Curator] is_a: MT:0002075 ! coat color [Term] id: MT:0004035 name: sublingual gland morphology namespace: Trait.ontology def: "malformation of the small mucin-producing salivary glands in the floor of the mouth beneath the tongue, anterior to the submandibular gland" [hdene:Howard Dene_Mouse Genome Informatics Curator] is_a: MT:0003792 ! major salivary gland morphology [Term] id: MT:0004036 name: muscle relaxation namespace: Trait.ontology def: "altered ability of the muscle to lengthen following contractions" [monikat:Monika Tomczuk_Mouse Genome Informatics Curator] is_a: MT:0002106 ! muscle physiology [Term] id: MT:0004038 name: lymphangiectasis namespace: Trait.ontology def: "dilation of the lymphatic vessels, the basic process that may result in the formation of a lymphangioma" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, J:71816] synonym: "dilated lymphatic vessels" EXACT [] synonym: "lymphectasia" EXACT [] synonym: "telangiectasia lymphatica" EXACT [] is_a: MT:0001879 ! lymphatic vessel morphology [Term] id: MT:0004039 name: cardiac cell glucose uptake namespace: Trait.ontology def: "ability of the cells of the heart to take in glucose" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] is_a: MT:0001544 ! cardiovascular system physiology [Term] id: MT:0004040 name: susceptibility to kidney reperfusion injury namespace: Trait.ontology def: "a change in the likelihood or extent of damage to the kidney when the blood supply is restored after a period of ischemia " [brs:Beverly Richards-Smith_Mouse Genome Informatics Curator] is_a: MT:0002136 ! kidney physiology [Term] id: MT:0004043 name: pH regulation namespace: Trait.ontology def: "anomaly in the function of the buffer systems of the body in combination with the respiratory and renal systems that control the relative acidity or alkalinity of the body, as measured by the concentration of hydrogen ion" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] subset: slim_pig is_a: MT:0001764 ! homeostasis [Term] id: MT:0004045 name: cell cycle checkpoint function namespace: Trait.ontology def: "anomaly in the amount of time spent at the points in the cell cycle (end of G1 phase, end of G2 phase, and during metaphase) which prevent the cell from progressing to the next phase when conditions are unfavorable" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0003077 ! cell cycle [Term] id: MT:0004046 name: mitosis namespace: Trait.ontology def: "anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis) " [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0003077 ! cell cycle [Term] id: MT:0004047 name: milk composition namespace: Trait.ontology def: "anomaly in the protein or lipid content or the appearance of milk" [smb:Susan M. Bello_Mouse Genome Informatics Curator] subset: slim_cattle relationship: part_of MT:0001882 ! lactation [Term] id: MT:0004049 name: acute promyelocytic leukemia namespace: Trait.ontology def: "rapid onset of abnormal leukocyte proliferation, manifesting as a severe bleeding disorder from coagulation abnormalities, and bone marrow infiltration of abnormal promyelocytes and myelocytes" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002026 ! leukemia [Term] id: MT:0004050 name: renal sympathetic nerve activity namespace: Trait.ontology is_a: MT:0002136 ! kidney physiology [Term] id: MT:0004053 name: synchondrosis namespace: Trait.ontology def: "anomalous or persistent cartilaginous fusion of two bones " [J:102870, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0000164 ! cartilage development [Term] id: MT:0004054 name: periocular mesenchyme morphology namespace: Trait.ontology def: "malformation in the mesenchymal cells that give rise to the corneal endothelium, corneal stroma, sclera, iris stroma, ciliary muscle, ciliary stroma, and trabecular meshwork of the eye" [J:102847, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0001286 ! eye development [Term] id: MT:0004056 name: heart muscle compact layer integrity namespace: Trait.ontology def: "any measurable characteristic pertaining to the the structural completeness or structural soundness of the outer, dense layer of the myocardium" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator", RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] synonym: "myocardial compact layer integrity" RELATED [] relationship: part_of MT:0000058 ! heart muscle compact layer morphology relationship: part_of MT:0000073 ! heart muscle integrity [Term] id: MT:0004058 name: ventricle papillary muscle integrity namespace: Trait.ontology def: "any measurable characteristic pertaining to the the structural completeness or structural soundness of one of the group of myocardial bundles which terminate in the chordae tendineae that attach to the cusps of the atrioventricular valves; each ventricle has an anterior and a posterior papillary muscle; the right ventricle sometimes has a septal papillary muscle" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] synonym: "musculus papillaris integrity" RELATED [] synonym: "ventricular papillary muscle integrity" RELATED [] relationship: part_of MT:0000063 ! ventricle papillary muscle morphology relationship: part_of MT:0000073 ! heart muscle integrity [Term] id: MT:0004062 name: right atrium volume namespace: Trait.ontology def: "physical bulk of or total amount of space encompassed by the left upper chamber of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] synonym: "right atrial mass" RELATED [] synonym: "right atrial volume" RELATED [] synonym: "right atrium mass" RELATED [] relationship: part_of MT:0000005 ! right atrium size [Term] id: MT:0004063 name: left atrium volume namespace: Trait.ontology def: "physical bulk of or total amount of space encompassed by the left upper chamber of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] synonym: "left atrial mass" RELATED [] synonym: "left atrial volume" RELATED [] synonym: "left atrium mass" RELATED [] relationship: part_of MT:0000012 ! left atrium size [Term] id: MT:0004065 name: susceptibility to induced muscular atrophy namespace: Trait.ontology def: "greater than expected wasting of muscle tissue after experimental manipulation (starvation, neurectomy, immobilization, etc)" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0002106 ! muscle physiology [Term] id: MT:0004066 name: Henson's node morphology namespace: Trait.ontology def: "malformation of cells in the small pit at the anterior end of the primitive streak that are important in determining left-right asymmetry" [smb:Susan M. Bello_Mouse Genome Informatics Curator] synonym: "abnormal embryonic node morphology" EXACT [] is_a: MT:0002231 ! primitive streak morphology [Term] id: MT:0004067 name: ventricle trabeculae morphology namespace: Trait.ontology def: "any measurable or observable characteristic related to the shape, structure, color or pattern of the supporting bundles of muscular fibers lining the walls of the ventricles of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] synonym: "ventricular trabeculae morphology" RELATED [] relationship: part_of MT:0005294 ! heart ventricle morphology [Term] id: MT:0004069 name: muscle spindle morphology namespace: Trait.ontology def: "anomalous structure of the sensory organs in muscle that are involved in the stretch reflex" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, Principles of Neural Science_3rd edition:ISBN 0-8385-8034-3] is_a: MT:0000990 ! skeletal muscle mechanoreceptor morphology [Term] id: MT:0004074 name: Schwann cell precursor morphology namespace: Trait.ontology def: "malformation or absence of the progenitors of cells that sheath the axons of the peripheral nervous system" [monikat:Monika Tomczuk_Mouse Genome Informatics Curator] is_a: MT:0001106 ! Schwann cell morphology [Term] id: MT:0004075 name: Schwann cell precursor number namespace: Trait.ontology def: "fewer numbers than normal of the progenitors of cells that sheath the axons of the peripheral nervous system" [monikat:Monika Tomczuk_Mouse Genome Informatics Curator] is_a: MT:0004074 ! Schwann cell precursor morphology [Term] id: MT:0004076 name: vitelline vascular remodeling namespace: Trait.ontology def: "anomaly in the conversion of the primary (honeycomb-like) vascular plexus of the yolk sac into a mature vascular network" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0003229 ! vitelline vascular morphology [Term] id: MT:0004077 name: striatum morphology namespace: Trait.ontology def: "malformation of a large cluster of dopaminergic nerve cells, consisting of the caudate nucleus and the putamen, that controls movement, balance, and walking" [Principles of Neural Science_3rd edition:ISBN 0-8385-8034-3] synonym: "abnormal neostriatum morphology" EXACT [] synonym: "abnormal striate body" EXACT [] is_a: MT:0000787 ! telencephalon morphology is_a: MT:0006007 ! basal ganglion morphology [Term] id: MT:0004078 name: caudate nucleus morphology namespace: Trait.ontology def: "malformation of one or both C-shaped structures containing input neurons involved with control of voluntary movement in the brain" [Principles of Neural Science_3rd edition:ISBN 0-8385-8034-3] is_a: MT:0004102 ! dorsal striatum morphology [Term] id: MT:0004079 name: putamen morphology namespace: Trait.ontology def: "malformation of the lens-shaped basal ganglion involved with control of voluntary movement in the brain" [Principles of Neural Science_3rd edition:ISBN 0-8385-8034-3] is_a: MT:0004102 ! dorsal striatum morphology [Term] id: MT:0004080 name: nucleus accumbens morphology namespace: Trait.ontology def: "malformation in the group of neurons located at the head of the caudate nucleus and anterior to the putamen; these neurons normally are involved in sensations of pleasure and reactions to addictive substances " [Principles of Neural Science_3rd edition:ISBN 0-8385-8034-3] synonym: "abnormal accumbens nucleus morphology" EXACT [] synonym: "abnormal Nacc morphology" EXACT [] is_a: MT:0004103 ! ventral striatum morphology is_a: MT:0004166 ! limbic system morphology [Term] id: MT:0004081 name: globus pallidus morphology namespace: Trait.ontology def: "malformation of one of the basal ganglia involved with control of voluntary movement in the brain; consists of an external and an internal segment" [Principles of Neural Science_3rd edition:ISBN 0-8385-8034-3] synonym: "abnormal paleostriatum" EXACT [] synonym: "abnormal pallidum morphology" EXACT [] is_a: MT:0000830 ! diencephalon morphology is_a: MT:0006007 ! basal ganglion morphology [Term] id: MT:0004082 name: habenula development namespace: Trait.ontology def: "anomaly in the group of nuclei that makes up the small eminence on the dorsomedial surface of the thalamus, just in front of the dorsal commissure on the lateral edge of the habenular trigone" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] comment: Note that the habenula term originally denoted the stalk of the pineal gland, but now refers to the habenular nucleus, a neighboring group of neurons in the epithalamus synonym: "abnormal pineal peduncle" EXACT [] is_a: MT:0000840 ! epithalamus morphology [Term] id: MT:0004083 name: polysyndactyly namespace: Trait.ontology def: "greater than 5 digits present on an autopod with interdigital webbing also present" [rbabiuk:Randall Babiuk_Mouse Genome Informatics Curator] is_a: MT:0000562 ! polydactyly is_a: MT:0000564 ! syndactyly [Term] id: MT:0004084 name: cardiac muscle relaxation namespace: Trait.ontology def: "ability of the cardiac/heart muscle to lengthen following contractions, often measured by dP/dt min" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] is_a: MT:0001544 ! cardiovascular system physiology is_a: MT:0004036 ! muscle relaxation [Term] id: MT:0004085 name: heartbeat namespace: Trait.ontology def: "regularly spaced contractions of the heart" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] is_a: MT:0001544 ! cardiovascular system physiology [Term] id: MT:0004087 name: muscle fiber morphology namespace: Trait.ontology def: "malformed or poorly developed muscle fibers, the cylindrical multinucleated muscle cells that contract when stimulated" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] subset: slim_pig is_a: MT:0002108 ! muscle morphology [Term] id: MT:0004088 name: sarcoplasmic reticulum morphology namespace: Trait.ontology def: "any structural abnormality in the endoplasmic reticulum of skeletal and cardiac muscle, i.e. the complex of vesicles, tubules, and cisternae that form a continuous structure around striated myofibrils, with a repetition of structure within each sarcomere " [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0004087 ! muscle fiber morphology [Term] id: MT:0004089 name: dilated sarcoplasmic reticulum namespace: Trait.ontology def: "an expansion in the volume in the endoplasmic reticulum of skeletal and cardiac muscle, i.e. the complex of vesicles, tubules, and cisternae that form a continuous structure around striated myofibrils, with a repetition of structure within each sarcomere" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0004088 ! sarcoplasmic reticulum morphology [Term] id: MT:0004090 name: sarcomere morphology namespace: Trait.ontology def: "any structural abnormality in the segment of a myofibril between two Z lines comprised of multi-protein complexes composed of three different filament systems; these systems work together to contract and relax muscle" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] subset: slim_pig is_a: MT:0004087 ! muscle fiber morphology [Term] id: MT:0004091 name: Z lines morphology namespace: Trait.ontology def: "any structural abnormality in the cross-striation bisecting the I band of striated muscle myofibrils and serving as the anchoring point of actin filaments at either end of the sarcomere" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] synonym: "abnormal intermediate disk" EXACT [] synonym: "abnormal Z band" EXACT [] synonym: "abnormal Z disk" EXACT [] is_a: MT:0004090 ! sarcomere morphology [Term] id: MT:0004092 name: Z line number namespace: Trait.ontology def: "count of the cross-striation bisecting the I band of striated muscle myofibrils and serving as the anchoring point of actin filaments at either end of the sarcomere" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0004091 ! Z lines morphology [Term] id: MT:0004093 name: Z line pattern namespace: Trait.ontology def: "organization of the cross-striation bisecting the I band of striated muscle myofibrils and serving as the anchoring point of actin filaments at either end of the sarcomere" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0004091 ! Z lines morphology [Term] id: MT:0004094 name: M line morphology namespace: Trait.ontology def: "any structural anomaly in the band in the center of the H band that contains proteins that crosslink the thick filament system (myosins) and the M-band part of the elastic filaments" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0004090 ! sarcomere morphology [Term] id: MT:0004095 name: ocular distichiasis namespace: Trait.ontology def: "presence of a double row of eyelashes on an eyelid, one or both of which are turned in against the eyeball" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, J:83436] is_a: MT:0001340 ! eyelid morphology [Term] id: MT:0004096 name: midbrain-hindbrain boundary development namespace: Trait.ontology def: "anomaly in the formation of the midbrain-hindbrain domain, comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages; an organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0003864 ! midbrain development [Term] id: MT:0004097 name: cerebellar cortex morphology namespace: Trait.ontology def: "any structural anomaly of the thin mantle of gray matter that covers the surface of each cerebral hemisphere, including the six layers of nerve cells and the nerve pathways that connect them; together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, Principles of Neural Science_3rd edition:ISBN 0-8385-8034-3] is_a: MT:0000849 ! cerebellum morphology [Term] id: MT:0004098 name: granule neuron morphology namespace: Trait.ontology def: "any structural anomaly of the small neurons of the granule cell layer that send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites" [Principles of Neural Science_3rd edition:ISBN 0-8385-8034-3] synonym: "abnormal granule cell" EXACT [] is_a: MT:0000886 ! cerebellar granule layer morphology [Term] id: MT:0004099 name: cerebellar glomerulus morphology namespace: Trait.ontology def: "any structural anomaly of an intertwined cluster of nerve fibers surrounded by glia where mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons" [Principles of Neural Science_3rd edition:ISBN 0-8385-8034-3] synonym: "abnormal cerebellar glomeruli" EXACT [] is_a: MT:0000886 ! cerebellar granule layer morphology [Term] id: MT:0004100 name: spinal cord interneuron morphology namespace: Trait.ontology def: "malformation or absence of neurons that exclusively interact with other neurons in the spinal cord" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0006004 ! interneuron morphology [Term] id: MT:0004101 name: brain interneuron morphology namespace: Trait.ontology def: "malformation or absence of neurons that exclusively interact with other neurons in the brain; this includes most brain neuronal cell types" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0006004 ! interneuron morphology [Term] id: MT:0004102 name: dorsal striatum morphology namespace: Trait.ontology def: "any structural abnormality of the regions of the caudate nucleus and the putamen that lie dorsal to the anterior commissure" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal caudate putamen complex" EXACT [] synonym: "abnormal caudate-putamen morphology" EXACT [] synonym: "abnormal caudatoputamen morphology" EXACT [] synonym: "abnormal dorsal basal ganglia" EXACT [] is_a: MT:0004077 ! striatum morphology [Term] id: MT:0004103 name: ventral striatum morphology namespace: Trait.ontology def: "any structural abnormality of the regions of the nucleus accumbens and some nuclei of the olfactory tubercle that lie ventral to the anterior commissure" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0004077 ! striatum morphology [Term] id: MT:0004104 name: eye shape namespace: Trait.ontology def: "alteration in the size, shape or organization of cells of the eye " [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0002092 ! eye morphology [Term] id: MT:0004105 name: corneal abrasion namespace: Trait.ontology def: "scraping away or denuding of the corneal surface" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0001312 ! cornea morphology [Term] id: MT:0004106 name: lymphatic vessel cell number namespace: Trait.ontology def: "increased cell number in lymphatic vessels" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0001879 ! lymphatic vessel morphology [Term] id: MT:0004107 name: thoracic duct morphology namespace: Trait.ontology def: "any structural abnormality in the largest lymph vessel in the body, beginning at the cisterna chyli at about the level of the second lumbar vertebra" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] synonym: "abnormal ductus thoracicus" EXACT [] synonym: "abnormal Pecquet duct" EXACT [] synonym: "abnormal van Horne canal" EXACT [] is_a: MT:0001879 ! lymphatic vessel morphology [Term] id: MT:0004108 name: esophageal peristalsis namespace: Trait.ontology def: "altered esophageal movement characterized by waves of alternate circular contraction and relaxation of the muscular walls that move the esophagus contents forward" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0001664 ! digestion [Term] id: MT:0004109 name: Sertoli cell development namespace: Trait.ontology def: "anomalous differentiation of cells that support germ cell differentiation in males" [llw2:Linda Washburn_Mouse Genome Informatics Curator] is_a: MT:0003830 ! testis development [Term] id: MT:0004111 name: coronary artery morphology namespace: Trait.ontology def: "any measurable or observable characteristic related to the shape, structure, color or pattern of any of the arteries that branch from the aorta to supply blood to the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] xref: MP:0004111 is_a: MT:0002191 ! artery morphology [Term] id: MT:0004112 name: arteriole integrity namespace: Trait.ontology def: "any measurable characteristic pertaining to the the structural completeness or structural soundness of the small diameter vessels that branch from the arteries and lead to the capillaries" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] is_a: MT:0003410 ! artery integrity [Term] id: MT:0004113 name: aortic arch morphology namespace: Trait.ontology def: "structural completeness, soundness, or configuration of the portion of the descending aorta proceeding from the arch of the aorta and extending to the diaphram" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] relationship: part_of MT:0000272 ! aorta morphology [Term] id: MT:0004114 name: atrioventricular node morphology namespace: Trait.ontology def: "any measurable or observable characteristic related to the shape, structure, color or pattern of the small nodular mass of specialized muscle fibers located in the interatrial septum near the opening of the coronary sinus; this node gives rise to the electrical connection between the atria and ventricles and responds to the sinoatrial node" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator", RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] relationship: part_of MT:0000019 ! right atrium morphology relationship: part_of MT:0004123 ! impulse conducting system morphology [Term] id: MT:0004115 name: sinoatrial node morphology namespace: Trait.ontology def: "any measurable or observable characteristic related to the shape, structure, color or pattern of the small mass of modified cardiac muscle fibers located at the junction of the superior vena cava and the right atrium that is the source of contraction impulses for the heart" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] synonym: "pacemaker morphology" EXACT [] synonym: "sinus node morphology" EXACT [] relationship: part_of MT:0000019 ! right atrium morphology relationship: part_of MT:0004123 ! impulse conducting system morphology [Term] id: MT:0004116 name: atrioventricular bundle conduction namespace: Trait.ontology def: "transfer of cardiac electrical impulses through the specialized cardiac muscle fibers that originates in the atrioventricular node and extends into the ventricle" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] synonym: "bundle of His conduction" EXACT [] is_a: MT:0003137 ! impulse conducting system function [Term] id: MT:0004117 name: atrioventricular bundle morphology namespace: Trait.ontology def: "any measurable or observable characteristic related to the shape, structure, color or pattern of the specialized cardiac muscle fibers that originate in the atrioventricular node and extend into the ventricle" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator", RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] relationship: part_of MT:0000019 ! right atrium morphology relationship: part_of MT:0004123 ! impulse conducting system morphology [Term] id: MT:0004118 name: baroreceptor morphology namespace: Trait.ontology def: "anomaly in the sensory nerve endings in the wall of the atria of the heart, vena cava, aortic arch and carotid sinus that are sensitive to changes in blood pressure" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal pressoreceptor morphology" EXACT [] is_a: MT:0000972 ! mechanoreceptor morphology [Term] id: MT:0004121 name: sarcolemma morphology namespace: Trait.ontology def: "structural anomaly in the plasma membrane of a muscle fiber that is capable of conducting electrical impulses" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal myolemma morphology" EXACT [] is_a: MT:0004087 ! muscle fiber morphology [Term] id: MT:0004122 name: sinoatrial node function namespace: Trait.ontology def: "function of the sinoatrial node" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] is_a: MT:0001636 ! heartbeat regularity [Term] id: MT:0004123 name: impulse conducting system morphology namespace: Trait.ontology def: "any measurable or observable characteristic related to the shape, structure, color or pattern of the impulse-conducting system composed of modified cardiac muscle and having the power of spontaneous rhythmicity and conduction more highly developed than the rest of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] xref: MP:0004123 relationship: part_of MT:0000266 ! cardiac morphology [Term] id: MT:0004124 name: Purkinje fiber morphology namespace: Trait.ontology def: "any measurable or observable characteristic related to the shape, structure, color or pattern of the cardiac muscle fibers composing the terminal portion of the heart conduction system located in the ventricle" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] relationship: part_of MT:0004123 ! impulse conducting system morphology [Term] id: MT:0004125 name: venule integrity namespace: Trait.ontology def: "any measurable characteristic pertaining to the the structural completeness or structural soundness of the minute vessels that collect deoxygenated blood from the capillary plexuses returns it to the veins" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] is_a: MT:0000118 ! vein integrity [Term] id: MT:0004127 name: hypodermis thickness namespace: Trait.ontology def: "increase in the width of the innermost and thickest layer of the skin composed of loose connective tissue containing adipocytes" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0003705 ! hypodermis morphology [Term] id: MT:0004128 name: adipocyte morphology namespace: Trait.ontology is_a: MT:0000003 ! adipose tissue morphology [Term] id: MT:0004129 name: respiratory quotient namespace: Trait.ontology def: "the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism" [J:94416] synonym: "abnormal respiratory exchange ratio" EXACT [] is_a: MT:0003948 ! gas homeostasis [Term] id: MT:0004130 name: muscle cell glucose uptake namespace: Trait.ontology def: "anomaly in the ability of muscle cells to take in glucose" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0002106 ! muscle physiology [Term] id: MT:0004131 name: embryonic ciliary morphology namespace: Trait.ontology def: "any structural malformation of the earliest cilia of the mouse embryo found on the cells of the embryonic node" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0004066 ! Henson's node morphology [Term] id: MT:0004133 name: heterotaxia namespace: Trait.ontology def: "abnormal arrangement of organs or parts of the body in relation to each other" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] synonym: "heterotaxis" EXACT [] synonym: "heterotaxy" EXACT [] is_a: MT:0002089 ! postnatal growth/weight/body size [Term] id: MT:0004134 name: chest morphology namespace: Trait.ontology def: "malformation of the part of the body between the neck and the abdomen" [J:59168, smb:Susan M. Bello_Mouse Genome Informatics Curator] subset: slim_cattle synonym: "abnormal thorax morphology" EXACT [] is_a: MT:0002089 ! postnatal growth/weight/body size [Term] id: MT:0004135 name: mammary gland embryonic development namespace: Trait.ontology def: "aberration in the differentiation of the mammary gland during early embryogenesis" [llw2:Linda Washburn_Mouse Genome Informatics Curator, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0000628 ! mammary gland development [Term] id: MT:0004136 name: tongue muscle morphology namespace: Trait.ontology def: "anomalous structure or development of the muscular portion of the tongue" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000759 ! skeletal muscle morphology [Term] id: MT:0004137 name: gastric surface mucous cell morphology namespace: Trait.ontology def: "malformation of the mucus secreting epithelial cells that line the luminal surface of the stomach, gastric pits and gastric glands" [monikat:Monika Tomczuk_Mouse Genome Informatics Curator] is_a: MT:0005209 ! gastric mucosa morphology [Term] id: MT:0004138 name: mucous neck cell morphology namespace: Trait.ontology def: "malformation of the mucin-producing epithelial cells present in the neck of the gastric glands " [monikat:Monika Tomczuk_Mouse Genome Informatics Curator] is_a: MT:0003892 ! gastric gland morphology [Term] id: MT:0004139 name: gastric parietal cell morphology namespace: Trait.ontology def: "malformation of the gastric acid producing epithelial cells that are distributed throughout the length of the gastric gland " [monikat:Monika Tomczuk_Mouse Genome Informatics Curator] synonym: "abnormal parietal cell morphology" EXACT [] is_a: MT:0003892 ! gastric gland morphology [Term] id: MT:0004140 name: chief cell morphology namespace: Trait.ontology def: "malformation of the pepsinogen producing epithelial cells that are clustered at the base of the gastric gland " [monikat:Monika Tomczuk_Mouse Genome Informatics Curator] is_a: MT:0003892 ! gastric gland morphology [Term] id: MT:0004141 name: enteroendocrine cell morphology namespace: Trait.ontology def: "malformation of the somatostatin and gastrin secreting epithelial cells present throughout the epithelium of the digestive tract" [monikat:Monika Tomczuk_Mouse Genome Informatics Curator] is_a: MT:0000511 ! intestinal mucosa morphology is_a: MT:0003892 ! gastric gland morphology [Term] id: MT:0004142 name: muscle tone namespace: Trait.ontology def: "anomaly in the resting tautness or laxity of a muscle, normally somewhere in the middle of the range between total contraction and total relaxation" [hdene:Howard Dene_Mouse Genome Informatics Curator] is_a: MT:0002106 ! muscle physiology [Term] id: MT:0004145 name: muscle electrophysiology namespace: Trait.ontology def: "anomaly in the function of the musculature as it relates to electrical phenomena" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] synonym: "abnormal muscle electrical activity" EXACT [] is_a: MT:0002106 ! muscle physiology [Term] id: MT:0004146 name: M line number namespace: Trait.ontology def: "count of the band in the center of the H band that contains proteins that crosslink the thick filament system (myosins) and the M-band part of the elastic filaments" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0004094 ! M line morphology [Term] id: MT:0004147 name: porphyrin level namespace: Trait.ontology def: "elevated concentration of porphyrins or protoporphyrins" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0001764 ! homeostasis [Term] id: MT:0004150 name: caveolae morphology namespace: Trait.ontology def: "physical appearance of the small pockets, vesicles, caves, or recesses communicating with the outside of a cell and extending inward, indenting the cytoplasm and the cell membrane" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0003950 ! plasma membrane morphology [Term] id: MT:0004152 name: circulating iron level namespace: Trait.ontology def: "anomalous blood concentration of this metallic element that normally occurs in the heme of hemoglobin, myoglobin, transferrin, ferritin, and iron-containing porphyrins; it is an essential component of enzymes such as catalase, peroxidase, and various cytochromes" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000179 ! blood chemistry is_a: MT:0001770 ! iron level [Term] id: MT:0004153 name: renal tubule apoptosis namespace: Trait.ontology def: "increase in the number of renal tubule cells undergoing programmed cell death" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0002703 ! renal tubule morphology [Term] id: MT:0004154 name: renal tubular necrosis namespace: Trait.ontology def: "pathological cell death in the proximal and/or distal renal tubules, usually due to irreversible damage " [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0003946 ! renal necrosis [Term] id: MT:0004155 name: susceptibility to induced pancreatitis namespace: Trait.ontology def: "level of inflammatory response in the pancreatic tissue after experimental manipulation" [honda:Hiraoki Onda_Mouse Genome Informatics Curator] is_a: MT:0001869 ! pancreas inflammation [Term] id: MT:0004162 name: mammillary body morphology namespace: Trait.ontology def: "any malformation or absence of the protrusion at the posterior end of the hypothalamus that contains hypothalamic nuclei" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0000837 ! hypothalamus morphology [Term] id: MT:0004163 name: adenophysis morphology namespace: Trait.ontology def: "any malformation or absence of the anterior part of the pituitary that secretes a variety of hormones; its function is regulated by the hypothalamus" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] synonym: "abnormal adenohypophysis morphology" EXACT [] is_a: MT:0000633 ! pituitary gland morphology [Term] id: MT:0004164 name: neurophysis morphology namespace: Trait.ontology def: "any malformation or absence of the part of the pituitary gland that secretes hormones involved in blood pressure regulation" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0000633 ! pituitary gland morphology [Term] id: MT:0004165 name: lateral geniculate nucleus morphology namespace: Trait.ontology def: "any malformation or absence of the group of neurons that serve as the primary processor of visual information received from the retina via the optic tract and send processed information to the visual cortex of the occipital lobe" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal LGN morphology" EXACT [] is_a: MT:0000832 ! thalamus morphology [Term] id: MT:0004166 name: limbic system morphology namespace: Trait.ontology def: "any malformation or absence of any of a collection of structures in the brain involved in emotion, motivation and emotional aspects of memory; these structures act together to control the endocrine system and the autonomic nervous system" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0000783 ! forebrain morphology [Term] id: MT:0004167 name: cingulate gyrus morphology namespace: Trait.ontology def: "any malformation or absence of the ridge in the cerebral cortex located dorsal to the corpus callosum that controls autonomic functions regulating heart rate and blood pressure as well as cognitive and attentional processing" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] synonym: "abnormal callosal gyrus morphology" EXACT [] synonym: "abnormal falciform lobe" EXACT [] is_a: MT:0000788 ! cerebral cortex morphology is_a: MT:0004169 ! fornicate gyrus morphology [Term] id: MT:0004168 name: parahippocampal gyrus morphology namespace: Trait.ontology def: "any malformation or absence of the ridge in the cerebral cortex that contains the olfactory cortex and that plays a role in the formation of topographical memory" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000801 ! temporal lobe morphology is_a: MT:0004169 ! fornicate gyrus morphology [Term] id: MT:0004169 name: fornicate gyrus morphology namespace: Trait.ontology def: "any malformation or absence of the horseshoe-shaped gyrus of the cerebral cortex that consists of the cingulate gyrus and the parahippocampal gyrus" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal limbic lobe morphology" EXACT [] is_a: MT:0004166 ! limbic system morphology [Term] id: MT:0004170 name: orbitofrontal cortex morphology namespace: Trait.ontology def: "any malformation or absence of the region of the cerebral cortex covering the basal surface of the frontal lobes; this region normally controls emotion and decision making" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0000798 ! frontal lobe morphology is_a: MT:0004166 ! limbic system morphology [Term] id: MT:0004171 name: pallium development namespace: Trait.ontology def: "anomaly in the progression of the formation of the roof region of the telencephalon" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0000934 ! telencephalon development [Term] id: MT:0004172 name: subpallium development namespace: Trait.ontology def: "anomaly in the progression of the formation of the base region of the telencephalon" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0000934 ! telencephalon development [Term] id: MT:0004173 name: intervertebral disk morphology namespace: Trait.ontology def: "malformation of the cartilaginous and gelatinous structure found between vertebrae" [smb:Susan M. Bello_Mouse Genome Informatics Curator] synonym: "abnormal intervertebral disc morphology" EXACT [] is_a: MT:0000137 ! vertebrae morphology is_a: MT:0000163 ! cartilage morphology [Term] id: MT:0004174 name: spine curvature namespace: Trait.ontology def: "deviation from the typical S-shape of the spine" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0002114 ! axial skeleton morphology [Term] id: MT:0004179 name: transmission ratio distortion namespace: Trait.ontology def: "the occurrence of an allele or haplotype in the offspring of an organism at skewed Mendelian ratios" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0005395 ! other trait [Term] id: MT:0004181 name: carotid artery integrity namespace: Trait.ontology def: "any measurable characteristic pertaining to the the structural completeness or structural soundness of any of the four arteries (two on each side of the neck; right and left internal carotid arteries, and right and left external carotid arteries) that deliver oxygen-rich blood from the heart to the head and brain" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] is_a: MT:0003410 ! artery integrity [Term] id: MT:0004182 name: spermiation namespace: Trait.ontology def: "failure of mature spermatozoa to release from supporting Sertoli cells into the lumen of seminiferous tubules" [llw2:Linda Washburn_Mouse Genome Informatics Curator] is_a: MT:0001932 ! spermiogenesis [Term] id: MT:0004183 name: sympathetic nervous system physiology namespace: Trait.ontology def: "anomaly in the function of the part of the autonomic nervous system that innervates smooth muscle, cardiac muscle and glands and mediates the body's response to stressful situations" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0006276 ! autonomic nervous system physiology [Term] id: MT:0004184 name: baroreceptor physiology namespace: Trait.ontology def: "anomaly in the function of the sensory nerve endings found in the wall of the atria of the heart, vena cava, aortic arch and carotid sinus that are sensitive to changes in blood pressure" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] synonym: "abnormal baroreflex function" EXACT [] synonym: "abnormal pressoreceptor physiology" EXACT [] is_a: MT:0004183 ! sympathetic nervous system physiology [Term] id: MT:0004185 name: adipocyte glucose uptake namespace: Trait.ontology is_a: MT:0005666 ! adipose tissue physiology [Term] id: MT:0004186 name: area postrema morphology namespace: Trait.ontology def: "structural malformation or absence of the small, elevated area in the lateral wall of the inferior recess of the fourth ventricle, involved in the control of cardiorespiratory physiology" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0000828 ! fourth ventricle morphology [Term] id: MT:0004188 name: timing of embryo turning namespace: Trait.ontology def: "completion of axial rotation occurs later than in controls but is eventually completed" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0001700 ! embryo turning [Term] id: MT:0004189 name: alveolar process namespace: Trait.ontology def: "malformation of the thickened ridge of bone that holds the tooth sockets" [smb:Susan M. Bello_Mouse Genome Informatics Curator] synonym: "abnormal alveolar body" EXACT [] synonym: "abnormal alveolar bone" EXACT [] is_a: MT:0000454 ! jaw morphology [Term] id: MT:0004190 name: direction of embryo turning namespace: Trait.ontology def: "axial rotation of the embryo in a direction other than the normal anticlockwise direction when viewed towards the caudal pole during the late primitive streak/early somite stage (Mus E8.5-E9.5); clockwise rotation is frequently associated with heart and visceral defects" [The Atlas of Mouse Development:ISBN 0-12-402035-6] is_a: MT:0001700 ! embryo turning [Term] id: MT:0004191 name: neuronal intranuclear inclusions namespace: Trait.ontology def: "presence of aggregates of protein within the nuclei of neurons; frequently seen in Huntington's disease" [acv:Alicia Valenzuela_Genetic Resources Curator] is_a: MT:0002882 ! neuron [Term] id: MT:0004192 name: kidney pyramid morphology namespace: Trait.ontology def: "malformation of the conical mass of tissue, containing part of the secreting and collecting tubules, whose base faces the renal cortex" [smb:Susan M. Bello_Mouse Genome Informatics Curator] synonym: "abnormal malpighian pyramid morphology" EXACT [] synonym: "abnormal medullary pyramid morphology" EXACT [] is_a: MT:0003014 ! kidney medulla morphology [Term] id: MT:0004193 name: kidney papilla morphology namespace: Trait.ontology def: "malformation of the apex of the renal pyramid that projects into a calyx" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0004192 ! kidney pyramid morphology [Term] id: MT:0004194 name: kidney pelvis morphology namespace: Trait.ontology def: "malformation of the funnel shaped proximal portion of the ureter that is formed by convergence of the major calices" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0002135 ! kidney morphology [Term] id: MT:0004195 name: calyx morphology namespace: Trait.ontology def: "malformation of any of the branches of the renal pelvis that surround each renal papilla and collect urine" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0004194 ! kidney pelvis morphology [Term] id: MT:0004196 name: prenatal growth/weight/body size namespace: Trait.ontology def: "limited or accelerated growth or development apparent before birth" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0005378 ! growth/size trait [Term] id: MT:0004197 name: fetal growth/weight/body size namespace: Trait.ontology def: "limited or accelerated growth or development apparent during the fetal period (sensu Mus: from E14 through birth)" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0004196 ! prenatal growth/weight/body size [Term] id: MT:0004198 name: fetal size namespace: Trait.ontology def: "anomalous proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0004197 ! fetal growth/weight/body size [Term] id: MT:0004201 name: fetal growth rate namespace: Trait.ontology def: "slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0004197 ! fetal growth/weight/body size [Term] id: MT:0004203 name: cranial flexure morphology namespace: Trait.ontology def: "any structural abnormality or absence of the sharp, ventrally concave bend in the developing midbrain of the embryo" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, J:10730] synonym: "abnormal cephalic flexure" EXACT [] synonym: "abnormal cerebral flexure" EXACT [] synonym: "abnormal mesencephalic flexure" EXACT [] is_a: MT:0003864 ! midbrain development [Term] id: MT:0004204 name: stapes size namespace: Trait.ontology def: "lenght, width, or area of the smallest and innermost of the three auditory ossicles" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0003739 ! middle ear ossicle size is_a: MT:0005107 ! stapes morphology [Term] id: MT:0004206 name: dermomyotome development namespace: Trait.ontology def: "malformation or absence of the portion of the embryonic somite that remains after migration of the sclerotomic tissue" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, J:50279] synonym: "abnormal dermamyotome development" EXACT [] is_a: MT:0000737 ! myotome development [Term] id: MT:0004207 name: squamous cell carcinoma namespace: Trait.ontology def: "a carcinoma that arises from stratified squamous epithelium that occurs in sites where glandular or columnar epithelium is normally present, such as the skin, esophagus, lungs and cervix" [rbabiuk:Randall Babiuk_Mouse Genome Informatics Curator] is_a: MT:0002038 ! carcinoma [Term] id: MT:0004208 name: basal cell carcinoma namespace: Trait.ontology def: "a slow-growing, invasive, but usually non-metastasizing neoplasm that originates from basal keratinocytes in the epidermis" [rbabiuk:Randall Babiuk_Mouse Genome Informatics Curator] is_a: MT:0002038 ! carcinoma [Term] id: MT:0004209 name: sweet taste sensitivity namespace: Trait.ontology def: "changes in the ability to perceive a particular flavor or suggestion of something sweet by the chemoreceptors of the gustatory system" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0001986 ! taste sensitivity [Term] id: MT:0004210 name: bitter taste sensitivity namespace: Trait.ontology def: "changes in the ability to perceive a particular flavor or suggestion of something bitter by the chemoreceptors of the gustatory system" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0001986 ! taste sensitivity [Term] id: MT:0004211 name: sour taste sensitivity namespace: Trait.ontology def: "changes in the ability to perceive a particular flavor or suggestion of something sour by the chemoreceptors of the gustatory system" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0001986 ! taste sensitivity [Term] id: MT:0004212 name: salty taste sensitivity namespace: Trait.ontology def: "changes in the ability to perceive a particular flavor or suggestion of something salty by the chemoreceptors of the gustatory system" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0001986 ! taste sensitivity [Term] id: MT:0004213 name: unami taste sensitivity namespace: Trait.ontology def: "changes in the ability to perceive a particular flavor or suggestion of something unami (savory) by the chemoreceptors of the gustatory system" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0001986 ! taste sensitivity [Term] id: MT:0004214 name: long bone diaphysis morphology namespace: Trait.ontology def: "abnormality/malformation of the main or mid section (shaft) of a long bone" [monikat:Monika Tomczuk_Mouse Genome Informatics Curator] synonym: "abnormal long bone shaft morphology" EXACT [] is_a: MT:0003723 ! long bone morphology [Term] id: MT:0004215 name: myocardial fiber function namespace: Trait.ontology def: "function of the multinucleated muscle cells of the heart" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] is_a: MT:0001544 ! cardiovascular system physiology [Term] id: MT:0004218 name: meiotic nondisjunction during M1 phase namespace: Trait.ontology def: "abnormal separation of pairs of homologous chromosomes during anaphase of the first meiotic division such that each daughter cell receives one set of paired chromosomes" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0001930 ! meiosis [Term] id: MT:0004219 name: meiotic nondisjunction during M2 phase namespace: Trait.ontology def: "abnormal separation of chromosomes during anaphase of the second meiotic division such that one complete chromosome goes to each daughter cell" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0001930 ! meiosis [Term] id: MT:0004220 name: peripheral nervous system regeneration namespace: Trait.ontology def: "changes in the ability or inability of healthy peripheral nervous system tissue to regenerate following injury or disease" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0003633 ! nervous system physiology [Term] id: MT:0004221 name: iridocorneal angle morphology namespace: Trait.ontology def: "any structural abnormality of the acute angle occurring between the iris and the cornea at the periphery of the anterior chamber of the eye" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] synonym: "abnormal angle of the iris" EXACT [] synonym: "abnormal filtration angle" EXACT [] is_a: MT:0005198 ! aqueous drainage system morphology [Term] id: MT:0004222 name: synechia namespace: Trait.ontology def: "an adhesion of parts, especially involving the iris e.g. attachments of the iris to the trabecular meshwork and peripheral cornea" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] synonym: "synechiae" EXACT [] is_a: MT:0001322 ! iris morphology [Term] id: MT:0004223 name: trabecular meshwork size namespace: Trait.ontology def: "reduced size of the pore-like structure surrounding the entire circumference of the anterior chamber through which aqueous humor circulates" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0005203 ! trabecular meshwork morphology [Term] id: MT:0004226 name: Schlemm's canal size namespace: Trait.ontology def: "length, width, area, or volume of the vascular structure encircling the anterior chamber of the eye, through which the aqueous humor is returned to the blood circulation" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0005204 ! canal of Schlemm morphology [Term] id: MT:0004228 name: cellular sensitivity to ionizing radiation namespace: Trait.ontology def: "level of ionizing radiation needed to induce a specific amount of cell death" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0000313 ! cell death [Term] id: MT:0004229 name: embryonic erythropoiesis namespace: Trait.ontology def: "anomaly in the development of primarily large, nucleated erythroblasts occurring in blood islands in the yolk sac, generally occurs from E7-E11 in the mouse and through 10 weeks in humans" [smb:Susan M. Bello_Mouse Genome Informatics Curator] synonym: "abnormal primitive erythropoiesis" EXACT [] is_a: MT:0003396 ! embryonic hematopoiesis [Term] id: MT:0004230 name: embryonic erythrocyte morphology namespace: Trait.ontology def: "structural anomaly of the embryonic blood cells that carry oxygen" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] synonym: "abnormal primitive erythrocyte morphology" EXACT [] is_a: MT:0004229 ! embryonic erythropoiesis [Term] id: MT:0004231 name: calcium ion homeostasis namespace: Trait.ontology def: "anomaly in the regulation of the levels, transport, and metabolism of calcium ions within the body or between a cell and its external environment" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] comment: not sure if this is the correct GO term; this is a cellular homeostasis term, not a whole-body physiologuiccal term xref: GO:0006874 is_a: MT:0001765 ! ion homeostasis [Term] id: MT:0004233 name: muscle weight namespace: Trait.ontology def: "any anomaly in the average muscle weight" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] subset: slim_cattle subset: slim_chkn subset: slim_pig is_a: MT:0002269 ! muscle size [Term] id: MT:0004234 name: masticatory muscle morphology namespace: Trait.ontology def: "anomalous structure of any of the muscles responsible for the movement of the jaws during mastication, including the masseter, temporal, and medial and lateral pterygoid muscles" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0000759 ! skeletal muscle morphology [Term] id: MT:0004235 name: masseter muscle morphology namespace: Trait.ontology def: "anomalous structure of the masticatory muscle of posterior cheek with origin from the inferior border and medial surface of the zygomatic arch, with insertion into the lateral surface of the ramus of the mandible, with nerve supply from the masseteric nerve, and whose action closes the jaw during chewing" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0004234 ! masticatory muscle morphology [Term] id: MT:0004236 name: masseter muscle size namespace: Trait.ontology def: "physical bulk of the masticatory muscle of posterior cheek" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0004235 ! masseter muscle morphology [Term] id: MT:0004237 name: pterygoid muscle morphology namespace: Trait.ontology def: "anomalous structure of the muscles descending from the sphenoid bone to the lower jaw including the internal, or medial, pterygoid muscle and external, or lateral, pterygoid muscle. Action of the former is closing the jaws and that of the latter is opening the jaws, protruding the mandible, and moving the mandible from side to side" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0004234 ! masticatory muscle morphology [Term] id: MT:0004238 name: pterygoid muscle size namespace: Trait.ontology def: "physical bulk of either the internal or external or of both pterygoid muscles" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0004237 ! pterygoid muscle morphology [Term] id: MT:0004239 name: temporalis muscle morphology namespace: Trait.ontology def: "anomalous structure of the superior-most masticatory muscle" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] synonym: "abnormal musculus temporalis" EXACT [] synonym: "abnormal temporal muscle" EXACT [] synonym: "abnormal temporalis" EXACT [] is_a: MT:0004234 ! masticatory muscle morphology [Term] id: MT:0004240 name: temporalis muscle size namespace: Trait.ontology def: "length, width, or volume of the superior-most masticatory muscle" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0004239 ! temporalis muscle morphology [Term] id: MT:0004241 name: acantholysis namespace: Trait.ontology def: "separation of prickle cells of the spinous layer of the epidermis, resulting in atrophy of the prickle cell layer, as in conditions such as pemphigus vulgaris and Darier disease" [MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0001236 ! spinous layer morphology [Term] id: MT:0004242 name: plasmacytoid dendritic cell morphology namespace: Trait.ontology is_a: MT:0005461 ! dendritic cell morphology/development [Term] id: MT:0004243 name: motor nerve terminal sprouting namespace: Trait.ontology def: "aberrant response of a motor neuron to form new neuritic processes (sprouts) that emerge from the nodes of Ranvier or terminal arborizations in response to nerve injury (such as denervation), application of nerve toxin, or muscle inactivity (usually due to disease)" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0000940 ! motor neuron innervation [Term] id: MT:0004244 name: spontaneous abortion namespace: Trait.ontology def: "the natural or accidental termination of a pregnancy at a stage where the embryo or the fetus is incapable of surviving independently of the mother" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] subset: slim_cattle synonym: "miscarriage" EXACT [] is_a: MT:0003699 ! female reproductive system physiology [Term] id: MT:0004245 name: genital hemorrhage namespace: Trait.ontology def: "bleeding into the genitals" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0003699 ! female reproductive system physiology [Term] id: MT:0004246 name: extensor digitorum longus morphology namespace: Trait.ontology def: "malformation of penniform muscle of the lateral front part of the leg responsible for extension of the toes and dorsiflexion of the ankle" [smb:Susan M. Bello_Mouse Genome Informatics Curator] synonym: "abnormal EDL morphology" EXACT [] is_a: MT:0003358 ! hypaxial muscle morphology [Term] id: MT:0004248 name: epaxial muscle morphology namespace: Trait.ontology def: "malformation of the muscles derived from the medial myotome; includes the intrinsic back muscles" [PMID:1591996] subset: slim_cattle subset: slim_pig is_a: MT:0000759 ! skeletal muscle morphology [Term] id: MT:0004249 name: crista ampullaris morphology namespace: Trait.ontology def: "form or structure of the elevation found on the inner surface of the ampullae of each semicircular duct; filaments of the vestibular nerve pass through the crista to reach hair cells on its surface; the hair cells are capped by the cupula, a gelatinous protein-polysaccharide mass" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, J:60193] synonym: "cristae morphology" EXACT [] is_a: MT:0002428 ! semicircular canal [Term] id: MT:0004250 name: tau protein deposits namespace: Trait.ontology def: "formation of self-assembled tangles of paired helical filaments and straight filaments due to hyperphosphorylation of the tau protein; often seen in neuronal tissues of individuals with neurodegenerative disorders" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] synonym: "tau protein tangles" EXACT [] is_a: MT:0002152 ! brain morphology [Term] id: MT:0004252 name: heart tube looping direction namespace: Trait.ontology def: "orientation of bending during looping morphogenesis" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] synonym: "cardiac looping direction" RELATED [] relationship: part_of MT:0000269 ! heart tube looping morphogenesis [Term] id: MT:0004253 name: atrium appendage integrity namespace: Trait.ontology def: "any measurable characteristic pertaining to the the structural completeness or structural soundness of the small trabeculated chamber projecting from the atrium proper" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] synonym: "atrial appendage integrity" RELATED [] relationship: part_of MT:0000024 ! atrium appendage morphology relationship: part_of MT:0000053 ! heart integrity [Term] id: MT:0004254 name: cerebral amyloid angiopathy namespace: Trait.ontology def: "a pathological condition where there is a deposition of amyloid in the walls of the small cerebral vessels which supply the brain; this results in an increased risk of infarcts and/or intracerebral hemorrhage, possibly resulting in dementia" [acv:Alicia Valenzuela_Genetic Resources Curator] is_a: MT:0002152 ! brain morphology [Term] id: MT:0004255 name: spongiotrophoblast layer morphology (sensu Rodentia) namespace: Trait.ontology def: "anomaly in the structure of the outer structural layer of the rodent placenta" [PMID:11433360] is_a: MT:0001711 ! placenta morphology [Term] id: MT:0004256 name: maternal decidual layer morphology namespace: Trait.ontology def: "anomaly in the structure of the maternal uterine-derived portion of the placenta" [PMID:11433360] is_a: MT:0001711 ! placenta morphology [Term] id: MT:0004257 name: placenta weight namespace: Trait.ontology def: "any change in a measure of heaviness of the placenta compared to controls" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0004258 ! placenta size [Term] id: MT:0004258 name: placenta size namespace: Trait.ontology def: "anomaly in the size or shape of the organ of metabolic interchange between fetus and mother" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0001711 ! placenta morphology [Term] id: MT:0004261 name: embryonic neuroepithelium morphology namespace: Trait.ontology def: "structural anomaly in the epithelial cells that line the neural tube and develop into the neurons and glia of the nervous system and into the neural crest cells" [monikat:Monika Tomczuk_Mouse Genome Informatics Curator, Principles of Neural Science_3rd edition:ISBN 0-8385-8034-3] is_a: MT:0003861 ! nervous system development [Term] id: MT:0004262 name: physical strength namespace: Trait.ontology is_a: MT:0002066 ! motor capabilities/coordination/movement [Term] id: MT:0004263 name: limb posture namespace: Trait.ontology is_a: MT:0001504 ! posture [Term] id: MT:0004264 name: extraembryonic tissue physiology namespace: Trait.ontology def: "functional anomaly of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0001672 ! embryogenesis/ development [Term] id: MT:0004265 name: placental transport namespace: Trait.ontology def: "anomaly in the conveyance of metabolic products and nutrients across the placenta" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0004264 ! extraembryonic tissue physiology [Term] id: MT:0004266 name: pale placenta namespace: Trait.ontology def: "placenta lacking normal reddish coloration, often refers to bloodless condition" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0001711 ! placenta morphology [Term] id: MT:0004267 name: optic tract morphology namespace: Trait.ontology def: "malformation of the band of optic nerve fibers running from the optic chiasma to the lateral geniculate body and midbrain" [MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0000778 ! tract morphology [Term] id: MT:0004268 name: optic stalk morphology namespace: Trait.ontology def: "malformation of the narrow, proximal portion of the optic vesicle which connects the embryonic eye and forebrain" [Gray's Anatomy:ISBN 0-914294-08-3] is_a: MT:0001286 ! eye development [Term] id: MT:0004269 name: optic cup morphology namespace: Trait.ontology def: "malformation of double walled stuctured formed by expansion and invagination of the distal end of the optic vesicle that develops into the pigmented and sensory layers of the retina while the mouth of the optic cup eventually forms the pupil of the eye" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0001286 ! eye development [Term] id: MT:0004271 name: paw/hand/foot/hoof morphology namespace: Trait.ontology def: "malformation of the pedal or prehensile extremity of vertebrates" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] subset: slim_cattle subset: slim_pig synonym: "abnormal paw morphology" EXACT [] synonym: "abnormal paws" EXACT [] synonym: "paw abnormalities" RELATED [] is_a: MT:0002109 ! limb morphology [Term] id: MT:0004272 name: basement membrane morphology namespace: Trait.ontology def: "anomaly in the structure, organization and/or placement of the extracellular supportive tissue adjacent to the basal surface of the epithelia, including the epithelium of muscle cells, fat cells and Schwann cells; it is comprised of type IV collagen, laminin, and sulfated proteoglycans and other components and consists of two layers, the basal lamina and the lamina reticularis" [MeSH:National Library of Medicine_Medical Subject Headings, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] comment: Note: basal lamina and lamina reticularis (or of two basal laminae) compose the basement membrane. thus, in strict sense, the term basement membrane is different from and should not be confused with basal lamina. synonym: "abnormal basement lamina morphology" EXACT [] is_a: MT:0005395 ! other trait [Term] id: MT:0004273 name: basal lamina morphology namespace: Trait.ontology def: "anomaly in the structure of the sheet of extracellular matrix characteristically situated under epithelial cells, around muscles, nerves, capillaries, and fat cells, and situated between these elements and the underlying or surrounding connective tissue" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] comment: Note: basal lamina and lamina reticularis (or of two basal laminae) compose the basement membrane. thus, in strict sense, the term basement membrane is different from and should not be confused with basal lamina. is_a: MT:0004272 ! basement membrane morphology [Term] id: MT:0004274 name: embryonic/fetal subventricular zone morphology namespace: Trait.ontology synonym: "abnormal embryonic subventricular zone" EXACT [] synonym: "abnormal subventricular zone" BROAD [] synonym: "abnormal SVZ" BROAD [] is_a: MT:0003861 ! nervous system development [Term] id: MT:0004275 name: postnatal subventricular zone morphology namespace: Trait.ontology synonym: "abnormal subependymal layer" EXACT [] synonym: "abnormal subependymal plate" EXACT [] synonym: "abnormal subependymal zone" EXACT [] synonym: "abnormal subventricular zone" BROAD [] synonym: "abnormal SVZ" BROAD [] is_a: MT:0002152 ! brain morphology [Term] id: MT:0004276 name: medial ganglionic eminence morphology namespace: Trait.ontology synonym: "abnormal MGE" EXACT [] is_a: MT:0004274 ! embryonic/fetal subventricular zone morphology [Term] id: MT:0004277 name: lateral ganglionic eminence morphology namespace: Trait.ontology synonym: "abnormal LGE" EXACT [] is_a: MT:0004274 ! embryonic/fetal subventricular zone morphology [Term] id: MT:0004278 name: caudal ganglionic eminence morphology namespace: Trait.ontology synonym: "abnormal CGE" EXACT [] is_a: MT:0004274 ! embryonic/fetal subventricular zone morphology [Term] id: MT:0004279 name: rostral migratory stream morphology namespace: Trait.ontology def: "malformation of the transient structure formed by neurons migrating from the subventricular zone into the olfactory bulbs" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0006009 ! neuronal migration [Term] id: MT:0004280 name: oculomotor nucleus morphology namespace: Trait.ontology def: "malformation or disorganization of the group of motor neurons in the floor of the midbrain that gives rise to motor fibers of the oculomotor nerve " [monikat:Monika Tomczuk_Mouse Genome Informatics Curator] is_a: MT:0000897 ! midbrain morphology [Term] id: MT:0004281 name: hypoglossal nucleus morphology namespace: Trait.ontology def: "malformation or disorganization of the group of motor neurons throughout most of the length of the medulla oblongata that give rise to the motor fibers of the hypoglossal nerve" [monikat:Monika Tomczuk_Mouse Genome Informatics Curator] is_a: MT:0000846 ! medulla oblongata [Term] id: MT:0004284 name: Descemet membrane morphology namespace: Trait.ontology def: "any structural abnormality in the transparent homogeneous acellular layer found between the substantia propria and the endothelial layer of the cornea, considered to be a highly developed basement membrane" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, J:100136] synonym: "abnormal Descemet's membrane" EXACT [] synonym: "abnormal Duddell membrane" EXACT [] synonym: "abnormal entocornea" EXACT [] synonym: "abnormal hyaloid membrane" EXACT [] synonym: "abnormal lamina elastica posterior" EXACT [] synonym: "abnormal lamina limitans posterior corneae" EXACT [] synonym: "abnormal membrana hyaloidea" EXACT [] synonym: "abnormal membrana vitrea" EXACT [] synonym: "abnormal posterior elastic layer" EXACT [] synonym: "abnormal posterior limiting lamina of cornea" EXACT [] synonym: "abnormal posterior limiting layer of cornea" EXACT [] synonym: "abnormal tunica vitrea" EXACT [] synonym: "abnormal vitreous membrane" EXACT [] is_a: MT:0001312 ! cornea morphology [Term] id: MT:0004286 name: internal auditory canal morphology namespace: Trait.ontology def: "form or structure of the canal beginning at the opening of the internal acoustic meatus in the posterior cranial fossa, passing laterally through the petrous portion of the temporal bone to end at the fundus, where a thin plate of bone separates it from the vestibule; it gives passage to the facial and vestibulocochlear nerves together with the labyrinthine artery and veins" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] synonym: "internal acoustic meatus morphology" EXACT [] synonym: "internal auditory meatus morphology" EXACT [] synonym: "meatus auditorius internus morphology" EXACT [] is_a: MT:0000026 ! inner ear morphology [Term] id: MT:0004287 name: spiral limbus morphology namespace: Trait.ontology def: "form or structure of the border of the spiral lamina, i.e. the thickened periosteum covering the upper plate of the bony spiral lamina of the cochlea" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] synonym: "limbus laminae spiralis osseae morphology" EXACT [] synonym: "limbus spiralis morphology" EXACT [] is_a: MT:0000031 ! cochlea morphology [Term] id: MT:0004288 name: spiral ligament morphology namespace: Trait.ontology def: "form or structure of the thickened periosteal lining of the bony cochlea that forms the outer wall of the cochlear duct to which the basal lamina attaches" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] synonym: "crista spiralis morphology" EXACT [] synonym: "ligamentum spirale cochleae morphology" EXACT [] synonym: "ligamentum spirale ductus cochlearis morphology" EXACT [] synonym: "spiral crest morphology" EXACT [] synonym: "spiral ligament of cochlea morphology" EXACT [] synonym: "spiral ligament of cochlear duct morphology" EXACT [] is_a: MT:0003169 ! scala media morphology [Term] id: MT:0004289 name: bony labyrinth morphology namespace: Trait.ontology def: "any structural abnormality in the series of cavities (cochlea, vestibule, and semicircular canals) contained within the otic capsule of the petrous portion of the temporal bone; the bony labyrinth is filled with perilymph, in which the delicate, endolymph-filled membranous labyrinth is suspended" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] synonym: "abnormal labyrinthus osseus" EXACT [] synonym: "abnormal osseous labyrinth" EXACT [] is_a: MT:0000026 ! inner ear morphology [Term] id: MT:0004290 name: stapes footplate morphology namespace: Trait.ontology def: "form or structure of the flat portion of the stapes that fits in the oval window" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] synonym: "base of stapes" EXACT [] synonym: "basis stapedis morphology" EXACT [] is_a: MT:0005107 ! stapes morphology [Term] id: MT:0004291 name: conductive hearing function namespace: Trait.ontology def: "sound conduction through the middle-ear apparatus e.g. velocity transfer responses at the umbo or incus level during sound stimulation of the tympanic membrane" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] synonym: "middle-ear sound conduction" RELATED [] is_a: MT:0001963 ! hearing [Term] id: MT:0004292 name: spiral ligament fibrocyte morphology namespace: Trait.ontology def: "form or structure of any of the four types of fibrocytes (types I, II , III and IV) that constitute the spiral ligament" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0004288 ! spiral ligament morphology [Term] id: MT:0004293 name: type I spiral ligament fibrocyte morphology namespace: Trait.ontology def: "form or structure of type I spiral ligament fibrocytes which occupy the region beneath the stria vascularis" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0004292 ! spiral ligament fibrocyte morphology [Term] id: MT:0004294 name: type II spiral ligament fibrocytes morphology namespace: Trait.ontology def: "form or structure of type II spiral ligament fibrocytes found in the suprastrial zone and the central area of the spiral ligament beneath the spiral prominence" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0004292 ! spiral ligament fibrocyte morphology [Term] id: MT:0004295 name: type III spiral ligament fibrocyte morphology namespace: Trait.ontology def: "form or structure of type III spiral ligament fibrocytes which form a cell layer attached to the otic capsule" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0004292 ! spiral ligament fibrocyte morphology [Term] id: MT:0004296 name: type IV spiral ligament fibrocyte morphology namespace: Trait.ontology def: "form or structure of type IV spiral ligament fibrocytes found in the triangular space inferior to the basilar crest" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0004292 ! spiral ligament fibrocyte morphology [Term] id: MT:0004297 name: proprioceptive neuron morphology namespace: Trait.ontology def: "anomaly in the sensory neurons of the dorsal root ganglia that sense body position and send information about how much the muscle is stretched to the spinal cord" [hdene:Howard Dene_Mouse Genome Informatics Curator] is_a: MT:0000965 ! sensory neuron morphology is_a: MT:0002882 ! neuron [Term] id: MT:0004298 name: vestibular ganglion integrity namespace: Trait.ontology def: "loss of the group of bipolar sensory nerve cell bodies concerned with equilibration that form a swelling on the vestibular part of the eighth cranial nerve in the fundus of the internal acoustic meatus " [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] synonym: "degeneration of ganglion vestibulare " EXACT [] synonym: "degeneration of Scarpa ganglion" EXACT [] is_a: MT:0002856 ! vestibular ganglion morphology [Term] id: MT:0004300 name: organ of Corti supporting cell morphology namespace: Trait.ontology def: "form, structure, or number of the highly differentiated epithelial cells with distinctive morphological features surrounding the hair cells in the organ of Corti; inner hair cells (IHCs) are normally surrounded by (inner and outer) phalangeal cells while OHCs are in contact with Deiters and pillar cells; Hensen cells are positioned further laterally in the organ of Corti" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0000042 ! organ of Corti [Term] id: MT:0004302 name: Dieters cell morphology namespace: Trait.ontology def: "form, structure or number of the supporting cells of the spiral organ which are attached to the basement membrane and receive the hair cells between their free extremities" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] synonym: "abnormal phalangeal cell morphology" EXACT [] is_a: MT:0004300 ! organ of Corti supporting cell morphology [Term] id: MT:0004303 name: Hensen cell morphology namespace: Trait.ontology def: "form, structure or number of the supporting cells that form the lateral border of the organ of Corti, immediately to the outer side of Deiters' cells " [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0004300 ! organ of Corti supporting cell morphology [Term] id: MT:0004305 name: Rosenthal canal morphology namespace: Trait.ontology def: "form or structure of the winding tube of the bony labyrinth that makes two and a half turns about the modiolus of the cochlea; it is divided incompletely into two compartments by a winding shelf of bone, the bony spiral lamina" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] synonym: "canalis spiralis cochleae morphology" EXACT [] synonym: "cochlear canal morphology" EXACT [] is_a: MT:0000031 ! cochlea morphology is_a: MT:0002729 ! canal morphology [Term] id: MT:0004306 name: Rosenthal canal size namespace: Trait.ontology def: "reduced size of the winding tube of the bony labyrinth that makes two and a half turns about the modiolus of the cochlea" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] synonym: "small canalis spiralis cochleae" EXACT [] synonym: "small cochlear canal" EXACT [] is_a: MT:0004305 ! Rosenthal canal morphology [Term] id: MT:0004308 name: basilar membrane morphology namespace: Trait.ontology def: "form or structure of the membrane extending from the bony spiral membrane to the basilar crest of the cochlea; it forms the greater part of the floor of the cochlear duct separating the latter from the scala tympani, and it supports the organ of Corti" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] synonym: "basilar lamina morphology" EXACT [] synonym: "lamina basilaris cochleae morphology" EXACT [] synonym: "lamina basilaris ductus cochlearis morphology" EXACT [] synonym: "membrana basilaris morphology" EXACT [] synonym: "morphology of the basilar membrane of cochlear duct" EXACT [] is_a: MT:0000031 ! cochlea morphology [Term] id: MT:0004310 name: otic vesicle size namespace: Trait.ontology def: "area or volume of the simple epithelial sac formed from the otic placode that gives rise to the structures of the inner ear" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] synonym: "otocyst size" EXACT [] is_a: MT:0006030 ! otic vesicle formation [Term] id: MT:0004311 name: otic vesicle cell number namespace: Trait.ontology def: "number of cells in the simple epithelial sac formed from the otic placode that gives rise to the structures of the inner ear" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0006030 ! otic vesicle formation [Term] id: MT:0004313 name: vestibulocochlear ganglion size namespace: Trait.ontology def: "area of the group of neuron cell bodies associated with the eighth cranial nerve during embryogenesis; splits in later development to form the cochlear and vestibular ganglia" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0003703 ! vestibulocochlear ganglion morphology [Term] id: MT:0004316 name: saccule size namespace: Trait.ontology def: "length, width, area, or volume of the cavity between the semicircular canals and the cochlea of the inner ear" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0006089 ! saccule morphology [Term] id: MT:0004320 name: sternum shape namespace: Trait.ontology def: "appearance of the long flat bone of the chest which articulates with clavicle and first seven rib pairs" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0000157 ! sternum morphology [Term] id: MT:0004321 name: sternum length namespace: Trait.ontology def: "reduced length of the long flat bone of the chest which articulates with clavicle and first seven rib pairs" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0004323 ! sternum size [Term] id: MT:0004322 name: sternebra morphology namespace: Trait.ontology def: "malformation of one segments of the primordial sternum of the embryo; these segments fuse to form the body of the adult vertebrate sternum" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] synonym: "abnormal sternebrae morphology" EXACT [] is_a: MT:0000157 ! sternum morphology is_a: MT:0002113 ! skeleton development [Term] id: MT:0004323 name: sternum size namespace: Trait.ontology def: "reduced size of the sternum due to decreased cell number" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0000157 ! sternum morphology [Term] id: MT:0004324 name: vestibular hair cell integrity namespace: Trait.ontology def: "susceptibility of the vestibular hairs to loss or degeneration" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0002623 ! vestibular hair cell morphology [Term] id: MT:0004326 name: vestibular hair cell number namespace: Trait.ontology def: "number of cells in the sensory epithelium of the maculae and cristae of the membranous labyrinth of the internal ear" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0002623 ! vestibular hair cell morphology [Term] id: MT:0004329 name: saccular integrity namespace: Trait.ontology def: "susceptibility of the smaller of the two sacs in the vestibule to loss or degeneration" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0006089 ! saccule morphology [Term] id: MT:0004330 name: saccular macula morphology namespace: Trait.ontology def: "structure or form of the oval neuroepithelial sensory receptor in the anterior wall of the saccule; hair cells of the neuroepithelium support the statoconial membrane and have terminal arborizations of vestibular nerve fibers around their bodies" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] synonym: "macula sacculi morphology" EXACT [] synonym: "saccular spot morphology " RELATED [] is_a: MT:0006089 ! saccule morphology [Term] id: MT:0004331 name: saccular macula integrity namespace: Trait.ontology def: "susceptibility of the oval neuroepithelial sensory receptor in the anterior wall of the saccule to degeneration or loss" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0004330 ! saccular macula morphology [Term] id: MT:0004332 name: utricular integrity namespace: Trait.ontology def: "susceptibility of the larger of the two sacs in the vestibule to degeneration or loss" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0006090 ! utricle morphology [Term] id: MT:0004333 name: utricular macula morphology namespace: Trait.ontology def: "structure or form of the neuroepithelial sensory receptor in the inferolateral wall of the utricle; hair cells of the neuroepithelium support the statoconial membrane and have terminal arborizations of vestibular nerve fibers around their bodies; normally sensitive to linear acceleration in the longitudinal axis of the body and to gravitational influences" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] synonym: "macula utriculi morphology" EXACT [] synonym: "utricular spot morphology" EXACT [] is_a: MT:0006090 ! utricle morphology [Term] id: MT:0004334 name: utricular macular integrity namespace: Trait.ontology def: "susceptibility of the neuroepithelial sensory receptor in the inferolateral wall of the utricle to loss or degeneration" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0004333 ! utricular macula morphology [Term] id: MT:0004335 name: utricle size namespace: Trait.ontology def: "length, width, area, or volume of the larger of the two sacs in the vestibule" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0006090 ! utricle morphology [Term] id: MT:0004337 name: clavicle cell number namespace: Trait.ontology def: "reduced cell number resulting in reduced size of one or both of the doubly curved long bone that forms part of the shoulder girdle and articulates with the sternum and the scapula" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "hypoplastic clavicles" EXACT [] is_a: MT:0004338 ! clavicle size [Term] id: MT:0004338 name: clavicle size namespace: Trait.ontology def: "reduced size of one or both of the doubly curved long bone that forms part of the shoulder girdle and articulates with the sternum and the scapula" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0005298 ! clavicle morphology [Term] id: MT:0004340 name: scapula length namespace: Trait.ontology def: "reduced length of of either or both of the large, flat bones of the back part of the shoulder" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0004343 ! scapula size [Term] id: MT:0004342 name: scapular bone foramen namespace: Trait.ontology def: "presence of a hole in either or both of the large, flat bones of the back part of the shoulder" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] synonym: "hole in scapula" EXACT [] synonym: "scapula foramen" EXACT [] synonym: "scapula hole" EXACT [] synonym: "scapular hole" EXACT [] is_a: MT:0000149 ! scapula morphology [Term] id: MT:0004343 name: scapula size namespace: Trait.ontology def: "reduced size of either or both of the large, flat bones of the back part of the shoulder" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0000149 ! scapula morphology [Term] id: MT:0004344 name: scapular bone cell number namespace: Trait.ontology def: "reduced bone cell number in either or both of the large, flat bones of the back part of the shoulder" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0004343 ! scapula size [Term] id: MT:0004345 name: acromion morphology namespace: Trait.ontology def: "any structural anomaly of the lateral end of the spine of the scapula which projects as a broad flattened process and articulates with the clavicle, and forms the point of the shoulder" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal acromial process morphology" EXACT [] is_a: MT:0000149 ! scapula morphology [Term] id: MT:0004347 name: scapular spine morphology namespace: Trait.ontology def: "any structural anomaly of the trianguar ridge on the dorsal aspect of the scapula which separates the supra- from the infraspinatous fossa and where the trapezius and deltoid muscles are attached " [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal spine of scapula" EXACT [] is_a: MT:0000149 ! scapula morphology [Term] id: MT:0004348 name: femur length namespace: Trait.ontology def: "increased length of the long bone of the thigh" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: ID:0000369 ! femur dimensions [Term] id: MT:0004350 name: humerus length namespace: Trait.ontology def: "increased length of one or both of the bones of the forelimb that articulates with the scapula above and the radius and ulna below" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] subset: slim_chkn is_a: MT:0005296 ! humerus morphology [Term] id: MT:0004353 name: deltoid tuberosity morphology namespace: Trait.ontology def: "any structural anomaly of a rough elevation at the middle of the lateral side of the shaft of the humerus to which the the deltoid muscle attaches" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal deltoid crest" EXACT [] synonym: "abnormal deltoid eminence" EXACT [] synonym: "abnormal deltoid impression" EXACT [] synonym: "abnormal deltoid process" EXACT [] is_a: MT:0005296 ! humerus morphology [Term] id: MT:0004355 name: radius length namespace: Trait.ontology def: "reduced length of the short bone of the lateral forearm" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000552 ! radius morphology [Term] id: MT:0004356 name: radius cell number namespace: Trait.ontology def: "reduced cell number in the short bone of the lateral forearm resulting in decreased size" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000552 ! radius morphology [Term] id: MT:0004357 name: tibia length namespace: Trait.ontology def: "increased length of the medial and larger of the two bones of the lower leg" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] subset: slim_chkn is_a: MT:0000558 ! tibia morphology [Term] id: MT:0004358 name: tibia curvature namespace: Trait.ontology def: "curvature of the medial and larger of the two bones of the lower leg" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "bent tibia" EXACT [] is_a: MT:0000558 ! tibia morphology [Term] id: MT:0004361 name: ulna curvature namespace: Trait.ontology def: "curvature of the medial and larger of the two bones of the forearm" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "bent ulna" EXACT [] is_a: MT:0005108 ! ulna morphology [Term] id: MT:0004362 name: cochlear hair cell integrity namespace: Trait.ontology def: "susceptipility of the sensory epithelial cells of the cochlea; these cells are in synaptic contact with the auditory nerve to degeneration or loss" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002622 ! cochlear hair cell morphology [Term] id: MT:0004363 name: stria vascularis integrity namespace: Trait.ontology def: "susceptibility of the stria vascularis to degeneration or loss" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0000048 ! stria vascularis morphology [Term] id: MT:0004364 name: stria vascularis size namespace: Trait.ontology def: "length, width, or area of the stria vascularis" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0000048 ! stria vascularis morphology [Term] id: MT:0004365 name: strial basal cell morphology namespace: Trait.ontology def: "form or structure of the polarized cells which are juxtaposed to fibrocytes in the underlying spiral ligament" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0000048 ! stria vascularis morphology [Term] id: MT:0004366 name: strial marginal cell morphology namespace: Trait.ontology def: "form or structure of the polarized columnar cells of epithelial origin which cover the lateral surface of the cochlear duct, secrete K+ and form a continuous sheet in contact with the endolymph; marginal cells form extensive interdigitations with the basal and intermediate cells in the normal adult stria" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0000048 ! stria vascularis morphology [Term] id: MT:0004367 name: strial intermediate cell morphology namespace: Trait.ontology def: "form or structure of the melanocytes known to migrate from the neural crest during ontogeny to become located between the epithelial marginal cell layer and the mesodermal basal cell layer within the intrastrial space; the predominant cellular component of the electrogenic machinery that generates an endocochlear potential (80-100 mV)" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] synonym: "cochlear melanocyte morphology" EXACT [] synonym: "stria vascularis intermediate cell morphology" EXACT [] synonym: "stria vascularis melanocyte morphology" RELATED [] synonym: "strial melanocyte morphology" EXACT [] is_a: MT:0000048 ! stria vascularis morphology is_a: MT:0002877 ! melanocyte morphology [Term] id: MT:0004368 name: stria vascularis blood vessel morphology namespace: Trait.ontology def: "any measurable or observable characteristic related to the shape, structure, color or pattern of the blood vessels supplying the stria vascularis in the cochlea of the inner ear" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] synonym: "morphology of the stria vascularis vasculature" EXACT [] synonym: "strial vascular morphology" EXACT [] xref: MP:0004368 is_a: MT:0000048 ! stria vascularis morphology is_a: MT:0001614 ! blood vessel morphology [Term] id: MT:0004370 name: ulna length namespace: Trait.ontology def: "increased length of the medial and larger of the two bones of the forearm" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0005108 ! ulna morphology [Term] id: MT:0004371 name: femur curvature namespace: Trait.ontology def: "curvature of the long bone of the thigh" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "bent femur" EXACT [] is_a: MT:0000559 ! femur morphology [Term] id: MT:0004372 name: fibula curvature namespace: Trait.ontology def: "curvature of the lateral and smaller bone of the lower limb" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "bent fibula" EXACT [] is_a: MT:0002187 ! fibula morphology [Term] id: MT:0004373 name: humerus curvature namespace: Trait.ontology def: "curvature of the bone of the forelimb that articulates with the scapula above and the radius and ulna below" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "bent humerus" EXACT [] is_a: MT:0005296 ! humerus morphology [Term] id: MT:0004374 name: radius curvature namespace: Trait.ontology def: "curvature of the short bone of the lateral forearm" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000552 ! radius morphology [Term] id: MT:0004381 name: hair follicle melanocyte morphology namespace: Trait.ontology def: "any structural anomaly of the cells that produce pigment in the hair follicles" [llw2:Linda Washburn_Mouse Genome Informatics Curator] is_a: MT:0002075 ! coat color is_a: MT:0002877 ! melanocyte morphology [Term] id: MT:0004382 name: hair follicle melanogenesis namespace: Trait.ontology def: "failure of or anomaly in the biosynthetic pathway of melanin formation in hair follicles" [llw2:Linda Washburn_Mouse Genome Informatics Curator] is_a: MT:0002075 ! coat color is_a: MT:0005077 ! melanogenesis [Term] id: MT:0004387 name: prechordal plate morphology namespace: Trait.ontology def: "any structural anomaly of the horseshoe-shaped thickening of the endoderm at the cranial (rostral) end of the primitive streak formed by the involution of Spemann's organizer cells which, together with the notochord, induces the formation of the neural plate from the overlying ectodermal cells and contributes mesodermal type cells to the surrounding tissue" [Principles of Neural Science_3rd edition:ISBN 0-8385-8034-3] synonym: "abnormal prochordal plate morphology" EXACT [] is_a: MT:0002084 ! developmental patterning [Term] id: MT:0004389 name: respiratory bronchiole morphology namespace: Trait.ontology def: "any structural anomaly of the smallest bronchioles, which connect the terminal bronchioles to alveolar ducts and have alveoli rising from their walls" [brs:Beverly Richards-Smith_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002267 ! bronchiole morphology [Term] id: MT:0004390 name: bronchoalveolar duct junction morphology namespace: Trait.ontology def: "any structural anomaly of the branch point connecting the respiratory bronchioles to the alveolar ducts" [brs:Beverly Richards-Smith_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002271 ! respiratory alveolar duct morphology is_a: MT:0004389 ! respiratory bronchiole morphology [Term] id: MT:0004391 name: respiratory conducting tube namespace: Trait.ontology def: "any structural anomaly of the tubes of the respiratory system that allows passage of air from the trachea to the alveoli of the lungs" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] synonym: "abnormal respiratory passage" EXACT [] is_a: MT:0001175 ! lung morphology [Term] id: MT:0004392 name: CD8+ T cell physiology namespace: Trait.ontology def: "anomalous response of the subset of T lymphocytes that carry the CD8 marker" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0002444 ! T cell physiology [Term] id: MT:0004393 name: cochlear inner hair cell morphology namespace: Trait.ontology def: "structure or form of the sensory cells of the organ of Corti which are in synaptic contact with sensory as well as efferent fibers of the auditory nerve; there is a single row of flask-shaped inner hair cells tightly surrounded by supporting interphalangeal cells; the apical end of each cell is anchored to the cuticular plate and about 100 stereocilia arranged in a more or less linear (or shallow) U-shaped pattern extend from the cell's surface through the cuticular plate into the endolymphic space inferior to the tectorial membrane" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] synonym: "cochlear IHC morphology" EXACT [] is_a: MT:0002622 ! cochlear hair cell morphology [Term] id: MT:0004394 name: cochlear inner hair cell number namespace: Trait.ontology def: "number of the flask-shaped inner hair sensory cells of the organ of Corti which are in synaptic contact with sensory as well as efferent fibers of the auditory nerve" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0004393 ! cochlear inner hair cell morphology is_a: MT:0004406 ! cochlear hair cell number [Term] id: MT:0004398 name: cochlear inner hair cell integrity namespace: Trait.ontology def: "susceptibility of the single row of flask-shaped inner hair sensory cells of the organ of Corti to degeneration or loss" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0004362 ! cochlear hair cell integrity is_a: MT:0004393 ! cochlear inner hair cell morphology [Term] id: MT:0004399 name: cochlear outer hair cell morphology namespace: Trait.ontology def: "structure or form of the sensory cells of the organ of Corti which are in synaptic contact with sensory as well as efferent fibers of the auditory nerve; there are three rows of columnar outer hair cells largely surrounded by cortilymph and supporting phalangeal cells; the apical end of each cell is anchored to the cuticular plate and about 100 stereocilia arranged in a V-shaped pattern extend from the cell's surface through the cuticular plate into the tectorial membrane" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] synonym: "cochlear OHC morphology" EXACT [] is_a: MT:0002622 ! cochlear hair cell morphology [Term] id: MT:0004400 name: cochlear outer hair cell number namespace: Trait.ontology def: "number of the columnar outer hair sensory cells of the organ of Corti" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0004399 ! cochlear outer hair cell morphology is_a: MT:0004406 ! cochlear hair cell number [Term] id: MT:0004404 name: cochlear outer hair cell integrity namespace: Trait.ontology def: "susceptibility of the columnar outer hair sensory cells of the organ of Corti to degeneration or loss" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0004362 ! cochlear hair cell integrity is_a: MT:0004399 ! cochlear outer hair cell morphology [Term] id: MT:0004406 name: cochlear hair cell number namespace: Trait.ontology def: "number of the sensory epithelial cells of the cochlea, which are normally in synaptic contact with the auditory nerve" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0002622 ! cochlear hair cell morphology [Term] id: MT:0004409 name: ampullary crest neuroepithelium morphology namespace: Trait.ontology def: "shape or structure of the specialized sensory hair cells of the ampullary crest of the ampulla of each semicircular duct" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0004249 ! crista ampullaris morphology [Term] id: MT:0004412 name: cochlear potential namespace: Trait.ontology def: "bioelectric potentials produced by the hair cells of the organ of Corti in response to sound; cochlear microphonics faithfully represent the frequency and intensity of the acoustic stimulation" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] synonym: "abnormal cochlear microphonic(s)" EXACT [] is_a: MT:0000365 ! hearing electrophysiology is_a: MT:0000483 ! sensorineural hearing function [Term] id: MT:0004415 name: cochlear nerve compound action potential namespace: Trait.ontology def: "the combined potentials resulting from activation of the auditory division of the eighth cranial nerve" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] synonym: "auditory nerve compound action potential" RELATED [] is_a: MT:0000365 ! hearing electrophysiology is_a: MT:0000483 ! sensorineural hearing function is_a: MT:0005402 ! action potential [Term] id: MT:0004423 name: squamosal bone morphology namespace: Trait.ontology def: "any structural anomaly of the thin, platelike part of the temporal bone" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0005272 ! temporal bone morphology [Term] id: MT:0004425 name: otolith organ morphology namespace: Trait.ontology def: "form or structure of the utricle and saccule of the inner ear which possess otoliths and respond to linear acceleration and deceleration, including gravity" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0000034 ! vestibule morphology [Term] id: MT:0004426 name: cochlear labyrinth morphology namespace: Trait.ontology def: "form or structure of the portion of the membranous labyrinth concerned with the sense of hearing (vs. the vestibular labyrinth, which is concerned with the sense of equilibration) and innervated by the cochlear nerve; it is located within the cochlea of the bony labyrinth, and consists of the cochlear duct, which contains the spiral organ " [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] synonym: "labyrinthus cochlearis morphology" EXACT [] synonym: "organ of hearing morphology" EXACT [] is_a: MT:0000035 ! membranous labyrinth [Term] id: MT:0004427 name: vestibular labyrinth morphology namespace: Trait.ontology def: "form or structure of the portion of the membranous labyrinth concerned with the sense of equilibration (vs. the cochlear labyrinth, which is concerned with the sense of hearing) and innervated by the vestibular nerve; it is located within the semicircular canals and vestibule of the bony labyrinth, and consists of the utricle, saccule, and the semicircular, utriculosaccular, and endolymphatic ducts " [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] synonym: "labyrinthus vestibularis morphology" EXACT [] synonym: "vestibular organ morphology" EXACT [] is_a: MT:0000035 ! membranous labyrinth [Term] id: MT:0004428 name: type I vestibular cell morphology namespace: Trait.ontology def: "form, structure, number or organization of the flask-shaped sensory cells of the maculae and cristae of the vestibular labyrinth of the inner ear, which are normally enclosed in calyx endings of afferent neurons; afferent and efferent nerve fibers of the vestibular nerve synapse with them; from the apical end of each cell a bundle of stereocilia and a kinocilium extend into the otolithic membrane of the maculae or the cupula of the cristae " [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0002623 ! vestibular hair cell morphology [Term] id: MT:0004429 name: type II vestibular cell morphology namespace: Trait.ontology def: "form, structure, number or organization of the cylindrical sensory cells of the maculae and cristae of the vestibular labyrinth of the inner ear which are normally contacted by bouton endings of afferent and efferent neurons; afferent and efferent nerve fibers of the vestibular nerve synapse with them; from the apical end of each cell a bundle of stereocilia and a kinocilium extend into the otolithic membrane of the maculae or the cupula of the cristae" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0002623 ! vestibular hair cell morphology [Term] id: MT:0004430 name: Claudius cell morphology namespace: Trait.ontology def: "form or structure of the columnar cells located on the floor of the ductus cochlearis external to the spiral organ" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0003169 ! scala media morphology [Term] id: MT:0004431 name: hair cell mechanoelectric transduction namespace: Trait.ontology def: "conversion of mechanical energy into electric(al) energy by sensory cells, such as auditory and vestibular hair cells, required for auditory sensation" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0003879 ! hair cell physiology [Term] id: MT:0004432 name: cochlear hair cell physiology namespace: Trait.ontology def: "processes pertinent to the integrated function of cochlear hair cells i.e. the sensory cells in the spiral organ which are in synaptic contact with sensory as well as efferent fibers of the cochlear (auditory) nerve " [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0003879 ! hair cell physiology [Term] id: MT:0004433 name: cochlear inner hair cell physiology namespace: Trait.ontology def: "processes pertinent to the function of cochlear IHCs which constitute the true sensory cell type sending impulses via the cochlear (auditory) nerve" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] synonym: "abnormal cochlear IHC physiology" EXACT [] is_a: MT:0004432 ! cochlear hair cell physiology [Term] id: MT:0004434 name: cochlear outer hair cell physiology namespace: Trait.ontology def: "processes pertinent to the function of cochlear OHCs which are known to enhance the performance of the cochlea, both qualitatively (increased selectivity) and quantitatively (increased sensitivity); in addition to the mechanoelectric transduction required for auditory sensation, OHCs also perform electromechanical transduction, whereby transmembrane voltage drives rapid changes in the length and stiffness of OHCs at audio frequencies in vitro (electromotility)" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] synonym: "abnormal cochlear OHC physiology" EXACT [] is_a: MT:0004432 ! cochlear hair cell physiology [Term] id: MT:0004435 name: cochlear outer hair cell electromotility namespace: Trait.ontology def: "motility of the cochlear OHCs in response to electrical stimulation; normally, the motile response (i.e. rapid change in length and stiffness of OHCs) is closely coupled to the changing transduction current and provides a region-specific amplification in the movement of the spiral organ that enhances transduction at the IHCs in that specific region of the cochlear spiral, increasing both sensitivity and specificity; electromotility is believed to arise through voltage-gated conformational changes in motor protein (prestin) or proteins located in the lateral wall of the OHC" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] synonym: "abnormal electromechanical transduction" EXACT [] synonym: "abnormal OHC electromotility" EXACT [] is_a: MT:0004434 ! cochlear outer hair cell physiology [Term] id: MT:0004438 name: vestibular hair cell physiology namespace: Trait.ontology def: "processes pertinent to the integrated function of the sensory epithelium of the maculae and cristae in the membranous labyrinth of the inner ear" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0003879 ! hair cell physiology [Term] id: MT:0004442 name: occipital bone foramen namespace: Trait.ontology def: "presence of a hole in the bone at the lower, posterior part of the skull" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "hole in occipital bone" EXACT [] synonym: "occipital bone hole" EXACT [] is_a: MT:0005269 ! occipital bone morphology [Term] id: MT:0004446 name: split exoccipital bone namespace: Trait.ontology def: "the appearance of a division in the bone or region on the lateral sides of the great foremen of the skull, which often forms a part of the occipital in the adult, but is usually distinct in the young" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000080 ! exoccipital bone morphology [Term] id: MT:0004448 name: presphenoid bone morphology namespace: Trait.ontology def: "any structural anomaly of the anterior part of the body of the sphenoid bone in front of the basisphenoid; it is usually a separate bone in the young or fetus, but becomes a part of the sphenoid in the adult" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000104 ! sphenoid bone morphology [Term] id: MT:0004452 name: pterygoid process morphology namespace: Trait.ontology def: "any structural anomaly of the process projecting downward from either side of the sphenoid bone, in vertebrates divided into two plates, an inner and an outer (sometimes called the lateral and medial); the posterior nares pass through the space, called the pterygoid fossa, between the processes" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000104 ! sphenoid bone morphology [Term] id: MT:0004453 name: pterygoid bone morphology namespace: Trait.ontology def: "any structural anomaly of the bone region which corresponds to the inner plate of the pterygoid process of the mammalian skull" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0004452 ! pterygoid process morphology [Term] id: MT:0004457 name: orbitosphenoid bone morphology namespace: Trait.ontology def: "any structural anomaly of the bone that is situated in the orbit on either side of the presphenoid; it generally forms a part of the sphenoid in the adult, and may be independent in the young" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000104 ! sphenoid bone morphology [Term] id: MT:0004463 name: basisphenoid bone foramen namespace: Trait.ontology def: "the presence of one or more holes in part of the base of the cranium between the basioccipital and the presphenoid, which usually ossifies separately in the embryo or in the young, and becomes a part of the sphenoid in the adult; in many animals it persists as a separate bone between the basioccipital bone and the presphenoidal bone" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "basisphenoid bone hole" EXACT [] synonym: "hole in basisphenoid bone" EXACT [] is_a: MT:0000106 ! basisphenoid bone morphology [Term] id: MT:0004465 name: integrity of the supporting cells of the organ of Corti namespace: Trait.ontology def: "degeneration or loss of the highly differentiated epithelial cells with distinctive morphological features that surround all hair cells in the organ of Corti" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0004300 ! organ of Corti supporting cell morphology [Term] id: MT:0004466 name: cochlear outer hair cell length namespace: Trait.ontology def: "distance from tip to root of the cochlear outer hair cells" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0004399 ! cochlear outer hair cell morphology [Term] id: MT:0004469 name: zygomatic arch morphology namespace: Trait.ontology def: "any structural anomaly of the the bony arch in vertebrates that extends along the side or front of the skull beneath the eye socket and is formed by the temporal process of the zygomatic bone and the zygomatic process of the temporal bone" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal malar arch morphology" EXACT [] synonym: "abnormal zygoma morphology" EXACT [] is_a: MT:0005270 ! zygomatic bone morphology is_a: MT:0005272 ! temporal bone morphology [Term] id: MT:0004478 name: testicular teratoma namespace: Trait.ontology def: "neoplasms found in the testis that are composed of multiple tissue types; includes types not normally found in tesis" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002627 ! teratoma is_a: MT:0006262 ! testis tumor [Term] id: MT:0004479 name: oval window morphology namespace: Trait.ontology def: "structure or form of the oval opening on the medial wall of the tympanic cavity leading into the vestibule, close to the foot of the stapes" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "fenestra ovalis morphology" EXACT [] synonym: "fenestra vestibuli morphology" EXACT [] synonym: "morphology of the fenestra of the vestibule" EXACT [] synonym: "vestibular window morphology" EXACT [] is_a: MT:0000049 ! middle ear morphology [Term] id: MT:0004480 name: round window morphology namespace: Trait.ontology def: "structure or form of the opening on the medial wall of the middle ear leading into the cochlea, closed in life by the secondary tympanic membrane; serves to regulate fluid pressure in the inner ear" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "cochlear window morphology" EXACT [] synonym: "fenestra cochleae morphology" EXACT [] synonym: "fenestra rotunda morphology" EXACT [] synonym: "morphology of the fenestra of the cochlea" EXACT [] is_a: MT:0000049 ! middle ear morphology [Term] id: MT:0004481 name: conjunctival epithelium morphology namespace: Trait.ontology def: "any structural anomaly in the conjunctival layer of epithelial cells covering inner surface of the eyelid and the front of the eyeball except over the cornea" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0001310 ! conjunctiva morphology [Term] id: MT:0004482 name: interdental cell morphology namespace: Trait.ontology def: "form, structure, or number of the long, spindle-shaped cells arranged in parallel rows, oriented with their vertical axis perpendicular to the luminal surface of the spiral limbus; they secrete K+ into the endolymph and secrete the tectoral membrane" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0004287 ! spiral limbus morphology [Term] id: MT:0004487 name: type I spiral ligament fibrocyte integrity namespace: Trait.ontology def: "susceptibility of type I spiral ligament fibrocytes to degeneration or loss" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0004293 ! type I spiral ligament fibrocyte morphology [Term] id: MT:0004488 name: type II spiral ligament fibrocyte integrity namespace: Trait.ontology def: "susceptibility of type II spiral ligament fibrocytes to degeneration or loss" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0004294 ! type II spiral ligament fibrocytes morphology [Term] id: MT:0004489 name: type III spiral ligament fibrocyte integrity namespace: Trait.ontology def: "susceptibility of type III spiral ligament fibrocytes to degeneration or loss" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0004295 ! type III spiral ligament fibrocyte morphology [Term] id: MT:0004490 name: type IV spiral ligament fibrocyte integrity namespace: Trait.ontology def: "susceptibility of type IV spiral ligament fibrocytes to degeneration or loss" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0004296 ! type IV spiral ligament fibrocyte morphology [Term] id: MT:0004491 name: orientation of outer hair cell stereociliary bundles namespace: Trait.ontology def: "rotational direction of outer hair cell (OHC) stereociliary bundles, resulting in planar cell polarity of the inner ear sensory epithelium " [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0000892 ! orientation of cochlear hair cell stereociliary bundles is_a: MT:0001028 ! outer hair cell stereociliary bundle morphology [Term] id: MT:0004492 name: orientation of inner hair cell stereociliary bundles namespace: Trait.ontology def: "rotational direction of inner hair cell (IHC) stereociliary bundles, resulting in planar cell polarity of the inner ear sensory epithelium" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator] is_a: MT:0000892 ! orientation of cochlear hair cell stereociliary bundles is_a: MT:0001180 ! inner hair cell stereociliary bundle morphology [Term] id: MT:0004493 name: cochlear size namespace: Trait.ontology def: "area or volume of the cochlea" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0000031 ! cochlea morphology [Term] id: MT:0005000 name: immune tolerance namespace: Trait.ontology def: "the failure to respond to an antigen" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] is_a: MT:0001790 ! immune system physiology [Term] id: MT:0005001 name: clonal deletion namespace: Trait.ontology def: "a defect in the process of removal of immature lymphocytes that interact with self antigens during maturation" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] synonym: "clonal deletion abnormalities" EXACT [] is_a: MT:0005000 ! immune tolerance [Term] id: MT:0005002 name: T cell clonal deletion namespace: Trait.ontology def: "a defect in the process of removal of immature T lymphocytes that interact with self antigens during maturation" [Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] synonym: "T cell clonal deletion abnormalities" EXACT [] synonym: "T lymphocyte clonal deletion abnormalities" EXACT [] synonym: "T-cell clonal deletion abnormalities" EXACT [] is_a: MT:0005001 ! clonal deletion [Term] id: MT:0005004 name: clonal anergy namespace: Trait.ontology def: "unresponsiveness to an antigen" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] synonym: "anergy" EXACT [] is_a: MT:0005000 ! immune tolerance [Term] id: MT:0005005 name: self tolerance namespace: Trait.ontology def: "a defect in the normal lack of response to autologous (self) antigens" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] synonym: "self tolerance abnormalities" EXACT [] is_a: MT:0005000 ! immune tolerance [Term] id: MT:0005006 name: osteoblast physiology namespace: Trait.ontology def: "anomalous function of this bone-forming cell, which normally forms an osseous matrix in which it becomes enclosed as an osteocyte" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001533 ! skeleton physiology [Term] id: MT:0005007 name: bone density namespace: Trait.ontology def: "abnormal mineral content of bone" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] subset: slim_chkn synonym: "bone density anomalies" EXACT [] is_a: MT:0002896 ! bone mineralization [Term] id: MT:0005008 name: osteoblast formation namespace: Trait.ontology def: "anomalous development of this bone-forming cell, which normally forms an osseous matrix in which it becomes enclosed as an osteocyte" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal osteoplast formation" EXACT [] is_a: MT:0000057 ! osteogenesis [Term] id: MT:0005010 name: CD8+ T cell morphology/development namespace: Trait.ontology def: "anomalous structure, formation, or numbers of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "CD8+ T cell abnormalities" EXACT [] synonym: "CD8+ T-cell abnormalities" EXACT [] is_a: MT:0002435 ! effector T cell morphology/development [Term] id: MT:0005012 name: eosinophil count namespace: Trait.ontology def: "fewer than normal eosinophil numbers " [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "decreased eosinophil number" EXACT [] is_a: MT:0000334 ! granulocyte number is_a: MT:0002443 ! eosinophil morphology/development [Term] id: MT:0005018 name: T cell number namespace: Trait.ontology def: "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "decreased T cell count" EXACT [] synonym: "decreased T-cell count" EXACT [] synonym: "decreased T-cell number" EXACT [] is_a: MT:0002145 ! T lymphocyte development [Term] id: MT:0005019 name: early pro-B cell morphology/development namespace: Trait.ontology def: "anomalous structure, development, or number of cells in the B lymphocyte lineage that undergo D-J rearrangement of the immunoglobulin heavy chain" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] comment: these cells express no surface Ig; cell surface markers for these cells are: CD45R, MHC class II, CD19, CD38, CD40 synonym: "early pro-B cell abnormalities" EXACT [] synonym: "early pro-B-cell abnormalities" EXACT [] is_a: MT:0005432 ! pro-B cell morphology/development [Term] id: MT:0005020 name: late pro-B cell morphology/development namespace: Trait.ontology def: "anomalous structure, development, or number of the cells in the B lymphocyte lineage that undergo V-DJ rearrangement of the immunoglobulin heavy chain" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] comment: these cells express no surface Ig; cell surface markers for these cells are: CD45R, MHC class II, CD19, CD38, CD40 synonym: "late pro-B cell abnormalities" EXACT [] synonym: "late pro-B-cell abnormalities" EXACT [] is_a: MT:0005432 ! pro-B cell morphology/development [Term] id: MT:0005022 name: immature B cell morphology/development namespace: Trait.ontology def: "anomalous structure, development, or number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] comment: these cells express IgM on their surface, in addition MT: CD45R, MHC class II, CD19, CD20, CD21, CD40 synonym: "immature B cell abnormalities" EXACT [] synonym: "immature B lymphocyte abnormalities" EXACT [] synonym: "immature B-cell abnormalities" EXACT [] is_a: MT:0002144 ! B lymphocyte development [Term] id: MT:0005023 name: wound healing namespace: Trait.ontology def: "aberrant process of repair of trauma to any tissues of the body, especially that caused by physical means" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0005164 ! response to injury [Term] id: MT:0005024 name: lymph node structure namespace: Trait.ontology def: "anomaly in lymph node morphology" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] is_a: MT:0002339 ! lymph node morphology [Term] id: MT:0005025 name: response to infection namespace: Trait.ontology def: "the body's reaction to invasion and multiplication of microorganisms in its tissues, or the body's reaction to components of or toxins produced by pathogenic microorganisms" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] subset: slim_cattle subset: slim_chkn subset: slim_pig is_a: MT:0001790 ! immune system physiology [Term] id: MT:0005026 name: susceptibility to parasitic infection namespace: Trait.ontology def: "reduced likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] subset: slim_cattle synonym: "increased resistance to parasitic infection" EXACT [] is_a: MT:0001793 ! susceptibility to infection [Term] id: MT:0005028 name: trophectoderm morphology namespace: Trait.ontology def: "malformed outermost layer of cells in the blastodermic vesicle, which will develop into the trophoblast layer and then contact the endometrium and take part in establishing the embryo's means of nutrition" [dlb:Donna Burkart_Mouse Genome Informatics Curator, J:57761, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001712 ! placental development is_a: MT:0002085 ! embryonic tissue morphology [Term] id: MT:0005029 name: amnion morphology namespace: Trait.ontology def: "malformed innermost layer of the extraembryonic membranes" [dlb:Donna Burkart_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002086 ! extraembryonic tissue morphology [Term] id: MT:0005031 name: trophoblast layer morphology namespace: Trait.ontology def: "malformation of the mesectodermal cell layer arising from the trophectoderm that erodes the uterine mucosa and contributes to the formation of the placenta" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal trophoblast" RELATED [] is_a: MT:0001711 ! placenta morphology [Term] id: MT:0005032 name: ectoplacental cone morphology namespace: Trait.ontology def: "any morphological anomaly of the thickened trophoblast of the blastocyst in rodents that becomes the fetal portion of the placenta" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] is_a: MT:0001712 ! placental development [Term] id: MT:0005033 name: trophoblast giant cell morphology namespace: Trait.ontology def: "anomaly of the cells covering the blastocyst that erode the uterine mucosa and contribute to the formation of the placenta" [dlb:Donna Burkart_Mouse Genome Informatics Curator, J:57761, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0005031 ! trophoblast layer morphology [Term] id: MT:0005034 name: anus morphology namespace: Trait.ontology def: "structural anomaly of the lower opening of the digestive tract" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal anus" EXACT [] synonym: "anus abnormalities" EXACT [] is_a: MT:0000462 ! digestive system morphology [Term] id: MT:0005035 name: perianal ulceration namespace: Trait.ontology def: "lesion around or near the anus" [cml:Cathleen M. Lutz_Mouse Genome Informatics Curator, J:71506] is_a: MT:0005034 ! anus morphology [Term] id: MT:0005036 name: diarrhea namespace: Trait.ontology def: "abnormally frequent discharge of semi-solid or fluid fecal matter from the bowel" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0003866 ! defecation [Term] id: MT:0005037 name: mucous diarrhea namespace: Trait.ontology def: "presence of considerable mucous in the stools" [J:71506, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "anal mucous discharge" EXACT [] is_a: MT:0005036 ! diarrhea [Term] id: MT:0005040 name: MHC II cell surface expression on macrophages namespace: Trait.ontology def: "anomaly in the ability of macrophages to express major histocompatibility complex class II at the cell surface" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, J:31326] is_a: MT:0002454 ! macrophage antigen presentation is_a: MT:0005042 ! level of surface class II molecules [Term] id: MT:0005041 name: antigen presentation via MHC class II namespace: Trait.ontology alt_id: MT:0001843 def: "anomaly in the process by which peptide, bound to major histocompatibility complex class II, is presented to lymphocytes at the surface of antigen presenting cells" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] is_a: MT:0001835 ! antigen presentation is_a: MT:0002453 ! B lymphocyte antigen presentation [Term] id: MT:0005042 name: level of surface class II molecules namespace: Trait.ontology def: "deviation from the normal concentration of major histocompatibility complex class II molecules expressed at the cell surface" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] comment: unlike class I, which is expressed by almost all nucleated cells, only B cells, macrophages, other antigen presenting cells (e.g., Langerhans' cells), and epithelial cells of the thymus express MHC class II at their surface is_a: MT:0005041 ! antigen presentation via MHC class II [Term] id: MT:0005043 name: assembly of class II molecules namespace: Trait.ontology def: "impaired production of major histocompatibility complex class II molecules" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] is_a: MT:0005041 ! antigen presentation via MHC class II [Term] id: MT:0005044 name: sepsis namespace: Trait.ontology def: "presence of various pathogenic organisms, or their toxins, in the blood or tissues" [J:82434, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0005025 ! response to infection [Term] id: MT:0005045 name: thymus cortex area namespace: Trait.ontology def: "reduced size of outer section of the thymus lobule" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, J:31167] is_a: MT:0002371 ! thymus cortex morphology [Term] id: MT:0005046 name: spleen white pulp formation namespace: Trait.ontology def: "lack of development of the lymphoid area of the spleen" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, J:31167] synonym: "absent spleen white pulp" EXACT [] is_a: MT:0002357 ! spleen white pulp morphology [Term] id: MT:0005047 name: celiac lymph node size namespace: Trait.ontology def: "increased size of the celiac lymph nodes" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, J:31167] is_a: MT:0000701 ! lymph node size [Term] id: MT:0005048 name: thrombosis namespace: Trait.ontology def: "formation within a tissue or the vascular lumen of a thrombus, an aggregation of coagulated blood containing platelets, fibrin, and entrapped cellular elements " [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Pathology:ISBN 0-397-51047-0] is_a: MT:0002551 ! blood coagulation [Term] id: MT:0005049 name: cytokine physiology namespace: Trait.ontology def: "functional anomaly of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] subset: slim_pig is_a: MT:0002501 ! inflammatory mediator physiology [Term] id: MT:0005050 name: chemotactic interleukin physiology namespace: Trait.ontology def: "functional anomaly of any of a subset of interleukins that are involved in attracting leukocytes to a site of tissue injury" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "chemotactic interleukins" EXACT [] is_a: MT:0002526 ! chemokine physiology [Term] id: MT:0005051 name: response to anesthetics namespace: Trait.ontology def: "a reaction that differs from normal to compounds that reversibly depress neuronal function" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "altered sensitivity to anesthetics" EXACT [] is_a: MT:0002585 ! response/metabolism to xenobiotics [Term] id: MT:0005053 name: response to pentobarbital namespace: Trait.ontology def: "a reaction to this anesthetic that differs from normal " [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "altered sensitivity to pentobarbital" EXACT [] is_a: MT:0005051 ! response to anesthetics [Term] id: MT:0005054 name: response to tribromoethanol namespace: Trait.ontology def: "a reaction to this anesthetic that differs from normal " [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "altered sensitivity to tribromoethanol" EXACT [] is_a: MT:0005051 ! response to anesthetics [Term] id: MT:0005055 name: response to alphaxalone namespace: Trait.ontology def: "a reaction to this anesthetic that differs from normal " [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "altered sensitivity to alphaxalone" EXACT [] is_a: MT:0005051 ! response to anesthetics [Term] id: MT:0005058 name: lysosome morphology namespace: Trait.ontology def: "anomalous structure of any of the cytoplasmic, membrane bound vesicles that contain a variety of hydrolases" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal lysosome" EXACT [] xref: GO:0005764 is_a: MT:0000358 ! cell content/ morphology [Term] id: MT:0005059 name: lysosomal protein accumulation namespace: Trait.ontology def: "buildup of protein in the lysosome" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] xref: GO:0007041 is_a: MT:0003172 ! lysosome physiology [Term] id: MT:0005060 name: accumulation of giant lysosomes in kidney/renal tubule cells namespace: Trait.ontology def: "buildup of contents in lysosomes in cells of the kidney tubules " [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, J:5590] is_a: MT:0002703 ! renal tubule morphology is_a: MT:0005058 ! lysosome morphology [Term] id: MT:0005061 name: eosinophil morphology namespace: Trait.ontology def: "structural anomaly of the granular leukocytes having a two-lobed nucleus and cytoplasm containing coarse, round granules that are uniform in size and stainable by eosin" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "eosinophil structural abnormalities" EXACT [] is_a: MT:0002443 ! eosinophil morphology/development [Term] id: MT:0005062 name: presence of giant granules in eosinophils namespace: Trait.ontology def: "increased size of granules within these cells" [J:5078] is_a: MT:0005061 ! eosinophil morphology [Term] id: MT:0005064 name: presence of giant granules in lymphocytes namespace: Trait.ontology def: "increased size of granules within these cells" [J:5078] is_a: MT:0002619 ! lymphocyte morphology/development [Term] id: MT:0005065 name: neutrophil morphology namespace: Trait.ontology def: "structural anomaly of the granular leukocytes that have a three- to five-lobed nucleus and a cytoplasm that contains inconspicuous granules stainable by neutral dyes" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "abnormal polymorphonuclear cell" EXACT [] synonym: "neutrophil structural abnormalities" EXACT [] is_a: MT:0002415 ! neutrophil morphology/development [Term] id: MT:0005066 name: presence of giant granules in neutrophils namespace: Trait.ontology def: "increased size of the granules within these cells" [J:5078] is_a: MT:0005065 ! neutrophil morphology [Term] id: MT:0005067 name: presence of melanin granules in retina namespace: Trait.ontology def: "pigment particles found in retina" [J:5078] is_a: MT:0005103 ! retinal pigmentation [Term] id: MT:0005068 name: NK cell morphology/development namespace: Trait.ontology def: "anomalous structure, differentiation, or number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] synonym: "abnormal NK cells" EXACT [] synonym: "natural killer cell abnormalities" EXACT [] synonym: "NK cell abnormalities" EXACT [] is_a: MT:0002619 ! lymphocyte morphology/development [Term] id: MT:0005069 name: NK cell physiology namespace: Trait.ontology def: "impaired function of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] synonym: "dysfunctional NK cells" EXACT [] synonym: "natural killer cell dysfunction" EXACT [] synonym: "NK cell dysfunction" EXACT [] is_a: MT:0003945 ! lymphocyte physiology [Term] id: MT:0005071 name: hair follicle melanin granule size namespace: Trait.ontology def: "increased size of the pigment particles in the hair follicle" [J:5078] is_a: MT:0005072 ! hair follicle melanin granule morphology [Term] id: MT:0005072 name: hair follicle melanin granule morphology namespace: Trait.ontology def: "anomalous pigment particles in the hair follicles" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "hair follicle melanin granule abnormalities" EXACT [] is_a: MT:0002076 ! hair follicle structure/orientation is_a: MT:0004381 ! hair follicle melanocyte morphology is_a: MT:0005075 ! melanosome morphology [Term] id: MT:0005073 name: granulocyte chemotaxis namespace: Trait.ontology def: "inability or reduced ability of neutrophils, eosinophils, or basophils to move in response to chemical stimuli" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, J:5405, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002462 ! granulocyte physiology [Term] id: MT:0005074 name: granulocyte bactericidal activity namespace: Trait.ontology def: "inability or reduced ability of neutrophils, eosinophils, or basophils to kill bacteria" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, J:5405] is_a: MT:0002462 ! granulocyte physiology [Term] id: MT:0005075 name: melanosome morphology namespace: Trait.ontology def: "anomalous structure of these tissue-specific cytoplasmic organelles within which melanin pigments are synthesized and stored" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, J:5346] synonym: "abnormal melanosome" EXACT [] xref: GO:0042470 is_a: MT:0002877 ! melanocyte morphology [Term] id: MT:0005076 name: cell differentiation namespace: Trait.ontology def: "anomaly in the process whereby relatively unspecialized cells, e. g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] xref: GO:0030154 is_a: MT:0005621 ! cell physiology [Term] id: MT:0005077 name: melanogenesis namespace: Trait.ontology def: "failure of or anomaly in the biosynthetic pathway of melanin formation in cells" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, J:5346] is_a: MT:0001186 ! pigmentation trait [Term] id: MT:0005078 name: cytotoxic T cell physiology namespace: Trait.ontology def: "impaired function of the subset of CD8+ T lymphocytes capable of directly killing appropriately targeted cells " [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "CTL dysfunction" EXACT [] synonym: "cytotoxic T cell dysfunction" EXACT [] synonym: "cytotoxic T lymphocyte dysfunction" EXACT [] synonym: "cytotoxic T-cell dysfunction" EXACT [] is_a: MT:0004392 ! CD8+ T cell physiology [Term] id: MT:0005079 name: cytotoxic T cell cytolysis namespace: Trait.ontology def: "impaired ability of these cells to destroy or dissolve targeted cells" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, J:6692] synonym: "defective CTL cytolysis" EXACT [] synonym: "defective cytotoxic T lymphocyte cytolysis" EXACT [] synonym: "defective cytotoxic T-cell cytolysis" EXACT [] is_a: MT:0005078 ! cytotoxic T cell physiology [Term] id: MT:0005081 name: stratum reticulare morphology namespace: Trait.ontology def: "structural anomaly of the thicker, deeper layer of the dermis, containing blood and lymph vessels, nerves and nerve endings, and hair follicles" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal stratum reticulare" EXACT [] synonym: "abnormal stratum reticulare corii" EXACT [] synonym: "abnormal stratum reticulare cutis" EXACT [] synonym: "abnormal tunica propria corii" EXACT [] is_a: MT:0001243 ! dermal layer morphology [Term] id: MT:0005082 name: clear layer morphology namespace: Trait.ontology def: "structural or developmental anomaly of the layer of lightly staining corneocytes in the deepest level of the stratum corneum; found primarily in the thick epidermis of the palmar and plantar skin" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal stratum lucidum" EXACT [] is_a: MT:0001240 ! cornified layer morphology [Term] id: MT:0005083 name: biliary tract morphology namespace: Trait.ontology def: "anomalous structure or development of the gall bladder or its ducts" [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal biliary tract" EXACT [] is_a: MT:0002138 ! liver/biliary system morphology [Term] id: MT:0005084 name: gall bladder morphology namespace: Trait.ontology def: "anomalous structure or development of the organ which serves as a storage reservoir for bile" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal gall bladder" EXACT [] synonym: "gallbladder abnormalities" EXACT [] is_a: MT:0005083 ! biliary tract morphology [Term] id: MT:0005085 name: gall bladder physiology namespace: Trait.ontology def: "anomalous action or function of the organ that stores and concentrates bile" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal gall bladder function" EXACT [] synonym: "abnormal gallbladder function" EXACT [] is_a: MT:0002139 ! liver/biliary system physiology [Term] id: MT:0005086 name: bile volume namespace: Trait.ontology def: "anomalous amount of bile in the gall bladder" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, J:82951] is_a: MT:0005085 ! gall bladder physiology [Term] id: MT:0005089 name: double-negative T cell count namespace: Trait.ontology def: "reduced numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] synonym: "decreased CD4-CD8- T cell count" EXACT [] synonym: "decreased CD4-CD8- T cell numbers" EXACT [] synonym: "decreased double-negative T cell numbers" EXACT [] synonym: "decreased double-negative T-cell numbers" EXACT [] is_a: MT:0002407 ! double-negative T cell morphology/development [Term] id: MT:0005092 name: double-positive T cell count namespace: Trait.ontology def: "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] synonym: "decreased CD4+CD8+ T cell count" EXACT [] synonym: "decreased CD4+CD8+ T cell numbers" EXACT [] synonym: "decreased double-positive T cell numbers" EXACT [] synonym: "decreased double-positive T-cell numbers" EXACT [] is_a: MT:0002408 ! double-positive T cell morphology/development [Term] id: MT:0005094 name: T cell proliferation namespace: Trait.ontology def: "anomaly in the clonal expansion of naive T cells" [Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] synonym: "abnormal T-cell proliferation" EXACT [] is_a: MT:0001828 ! T cell activation [Term] id: MT:0005096 name: erythroblastosis namespace: Trait.ontology def: "presence of erythroblasts in great number in the blood" [J:305, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001586 ! erythrocyte count [Term] id: MT:0005097 name: polychromatophilia namespace: Trait.ontology def: "condition characterized by the presence of red blood cells that have an affinity for acid, basic, and neutral stains" [J:305, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "polychromasia" EXACT [] is_a: MT:0002447 ! erythrocyte morphology [Term] id: MT:0005098 name: choroid morphology namespace: Trait.ontology def: "anomalous structure of the thin, highly vascularized membrane covering most of the posterior of the eye between the retina and the sclera" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "choroid abnormalities" EXACT [] is_a: MT:0005196 ! posterior uvea morphology [Term] id: MT:0005099 name: ciliary body morphology namespace: Trait.ontology def: "structural anomaly of the thickened portion of the vascular tunic, which lies between the choroid and the iris" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "ciliary body abnormalities" EXACT [] is_a: MT:0005194 ! anterior uvea morphology [Term] id: MT:0005100 name: choroid pigmentation namespace: Trait.ontology def: "anomalous coloring of the thin, highly vascularized membrane covering most of the posterior of the eye between the retina and the sclera" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001324 ! eye pigmentation is_a: MT:0005098 ! choroid morphology [Term] id: MT:0005101 name: ciliary body pigmentation namespace: Trait.ontology def: "anomalous coloring of the thickened portion of the vascular tunic, which lies between the choroid and the iris" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0005200 ! pigment epithelium of the eye [Term] id: MT:0005102 name: iris pigmentation namespace: Trait.ontology def: "anomalous coloring of the adjustable membrane, composed of the stroma and pigmented epithelium, located just in front of the crystalline lens within the eye" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001322 ! iris morphology is_a: MT:0001324 ! eye pigmentation [Term] id: MT:0005103 name: retinal pigmentation namespace: Trait.ontology def: "anomalous coloring of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0005201 ! retinal pigment epithelium morphology [Term] id: MT:0005104 name: tarsus morphology namespace: Trait.ontology def: "malformation or absence of any of the eight bones of the instep of the paw: tibiale, talus, calcaneus, navicular, 3 cuneiform, and cuboid bones" [Anatomy of the Rat:Greene EC_Hafner Publishing Co_1935, J:83132, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] comment: Note that humans only have seven tarsal bones, while rodents have eight. synonym: "abnormal tarsal bone" EXACT [] synonym: "abnormal tarsals" EXACT [] synonym: "abnormal tarsus" EXACT [] is_a: MT:0002115 ! skeleton extremities morphology [Term] id: MT:0005105 name: middle ear ossicle morphology namespace: Trait.ontology alt_id: MT:0003738 def: "form or structure of the three small bones of the middle ear" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "middle ear bone morphology" EXACT [] is_a: MT:0000049 ! middle ear morphology is_a: MT:0005508 ! skeleton morphology [Term] id: MT:0005106 name: incus morphology namespace: Trait.ontology def: "form or structure of the middle of the three auditory ossicles" [J:83132, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0005105 ! middle ear ossicle morphology [Term] id: MT:0005107 name: stapes morphology namespace: Trait.ontology def: "structure or form of the smallest and innermost of the three auditory ossicles" [J:83132, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal stapes" EXACT [] is_a: MT:0005105 ! middle ear ossicle morphology [Term] id: MT:0005108 name: ulna morphology namespace: Trait.ontology def: "malformation of the medial and larger of the two bones of the forearm" [J:83132, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal ulna" EXACT [] is_a: MT:0003723 ! long bone morphology [Term] id: MT:0005109 name: talus morphology namespace: Trait.ontology def: "malformation of the bone that articulates with the tibia and fibula" [J:83132, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal ankle bone" EXACT [] synonym: "abnormal talus" EXACT [] is_a: MT:0005104 ! tarsus morphology [Term] id: MT:0005110 name: talus size namespace: Trait.ontology def: "length, width, or area of the bone that articulates with the tibia and fibula" [J:83132, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0005109 ! talus morphology [Term] id: MT:0005112 name: anterior horn morphology namespace: Trait.ontology def: "anomalous structure of the ventral gray column of the spinal cord" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal anterior horn" EXACT [] synonym: "abnormal ventral horn" EXACT [] is_a: MT:0000955 ! spinal cord morphology [Term] id: MT:0005113 name: number of anterior horn cells namespace: Trait.ontology def: "fewer than the expected number of cells in the ventral gray column of the spinal cord" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0005112 ! anterior horn morphology [Term] id: MT:0005116 name: circulating pituitary hormone level namespace: Trait.ontology alt_id: MT:0005115 def: "aberration in the blood concentration of any of the hormones secreted by the pituitary" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] subset: slim_cattle subset: slim_chkn subset: slim_pig synonym: "abnormal circulating level of pituitary hormone" EXACT [] synonym: "abnormal serum level of pituitary hormone" EXACT [] is_a: MT:0003965 ! pituitary hormone level is_a: MT:0005418 ! circulating hormone level [Term] id: MT:0005119 name: circulating thyroid-stimulating hormone level namespace: Trait.ontology def: "less than expected blood concentration of the hormone that stimulates the growth and function of the thyroid gland" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] subset: slim_pig synonym: "decreased serum levels of thyroid-stimulating hormone" EXACT [] synonym: "decreased serum levels of thyropic hormone" EXACT [] synonym: "decreased serum levels of thyrotrophin" EXACT [] synonym: "decreased serum levels of thyrotropin" EXACT [] synonym: "decreased serum levels of TSH" EXACT [] is_a: MT:0003971 ! thyroid-stimulating hormone level is_a: MT:0005116 ! circulating pituitary hormone level [Term] id: MT:0005120 name: circulating growth hormone level namespace: Trait.ontology def: "less than the expected blood concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "decreased serum levels of GH" EXACT [] synonym: "decreased serum levels of growth hormone" EXACT [] synonym: "decreased serum levels of pituitary growth hormone" EXACT [] synonym: "decreased serum levels of somatotropic hormone" EXACT [] synonym: "decreased serum levels of somatropin" EXACT [] is_a: MT:0003968 ! growth hormone level is_a: MT:0005116 ! circulating pituitary hormone level [Term] id: MT:0005121 name: circulating prolactin level namespace: Trait.ontology def: "less than expected blood concentration of the hormone that stimulates milk secretion " [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "decreased serum levels of galactopoietic hormone" EXACT [] synonym: "decreased serum levels of lactation hormone" EXACT [] synonym: "decreased serum levels of lactogenic hormone" EXACT [] synonym: "decreased serum levels of lactotropin" EXACT [] synonym: "decreased serum levels of mammotropic factor" EXACT [] synonym: "decreased serum levels of mammotropic hormone" EXACT [] synonym: "decreased serum levels of PRL" EXACT [] synonym: "decreased serum levels of prolactin" EXACT [] is_a: MT:0003361 ! circulating gonadotropin level is_a: MT:0003970 ! prolactin level is_a: MT:0005116 ! circulating pituitary hormone level [Term] id: MT:0005144 name: circulating VLDL cholesterol level namespace: Trait.ontology def: "anomalous concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal VLDL cholesterol level" EXACT [] is_a: MT:0000180 ! circulating cholesterol level [Term] id: MT:0005149 name: gubernaculum morphology namespace: Trait.ontology def: "dysmorphology of the genitoinguinal ligaments that, in the male, connect the fetal testis to the developing scrotum, and, in the female, connect the ovaries to the uterus" [J:55881, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal gubernaculae" EXACT [] is_a: MT:0002160 ! reproductive system morphology [Term] id: MT:0005150 name: cachexia namespace: Trait.ontology def: "general weight loss and wasting occurring in the course of chronic disease" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "emaciation" EXACT [] synonym: "wasting" EXACT [] is_a: MT:0001263 ! weight loss [Term] id: MT:0005151 name: diffuse hepatic necrosis namespace: Trait.ontology def: "disseminated pathologic death of cells within the liver" [J:20450, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001654 ! hepatic necrosis [Term] id: MT:0005152 name: pancytopenia namespace: Trait.ontology def: "reduction in the number of erythrocytes, all types of white blood cells, and platelets in the circulating blood" [J:20450, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000221 ! WBC count is_a: MT:0000228 ! thrombopoiesis is_a: MT:0001586 ! erythrocyte count [Term] id: MT:0005153 name: B cell proliferation namespace: Trait.ontology def: "change from normal in the ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "abnormal B lymphocyte proliferation" EXACT [] synonym: "abnormal B-cell proliferation" EXACT [] is_a: MT:0002459 ! B cell physiology [Term] id: MT:0005155 name: herniated intestine namespace: Trait.ontology def: "protrusion of any portion of the intestine from its normal anatomical position" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "intestinal hernia" EXACT [] synonym: "intestinal herniation" EXACT [] is_a: MT:0000477 ! intestine morphology [Term] id: MT:0005157 name: holoprosencephaly namespace: Trait.ontology def: "presence of a single forebrain hemisphere or lobe; often accompanied by a deficit in median facial development" [J:83058, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000913 ! brain development [Term] id: MT:0005158 name: ovary cell number namespace: Trait.ontology def: "underdeveloped ovaries, usually due to reduced cell number" [J:78931, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "hypoplastic ovaries" EXACT [] synonym: "hypoplastic ovary" EXACT [] synonym: "ovarian hypoplasia" EXACT [] is_a: MT:0001127 ! ovary size [Term] id: MT:0005159 name: azoospermia namespace: Trait.ontology def: "absence of living spermatozoa " [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "absence of sperm" EXACT [] synonym: "absent sperm" EXACT [] synonym: "aspermia" EXACT [] is_a: MT:0001156 ! spermatogenesis is_a: MT:0002209 ! germ cell number is_a: MT:0002673 ! sperm count [Term] id: MT:0005160 name: urine protein level namespace: Trait.ontology def: "presence of excess serum protein in the urine, usually albumin, but also globulin" [J:78193, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001757 ! urine chemistry [Term] id: MT:0005161 name: hematuria namespace: Trait.ontology def: "presence of blood in the urine" [J:78193, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001757 ! urine chemistry [Term] id: MT:0005162 name: ability to move the wrist/hand namespace: Trait.ontology is_a: MT:0000753 ! ability to move [Term] id: MT:0005163 name: cyclopia namespace: Trait.ontology def: "a congenital defect in which the two orbits are united to form a single cavity containing one eye" [J:60303, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "cyclopea" EXACT [] synonym: "one eye" EXACT [] synonym: "synophthalmia" EXACT [] synonym: "synophthalmus" EXACT [] is_a: MT:0001286 ! eye development [Term] id: MT:0005164 name: response to injury namespace: Trait.ontology def: "anomaly in the body's reaction to trauma, especially that by physical means" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001790 ! immune system physiology [Term] id: MT:0005166 name: susceptibility to injury namespace: Trait.ontology def: "less than the normal reaction to trauma, especially that by physical means" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "decreased response to injury" EXACT [] is_a: MT:0005164 ! response to injury [Term] id: MT:0005167 name: blood-brain barrier integrity namespace: Trait.ontology def: "any measurable characteristic pertaining to the the structural completeness or structural soundness of the group of barriers and transport systems in the brain capillary endothelium that controls the entrance of substances into the brain extracellular space from the blood" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] comment: this should only be in the morphology branch relationship: part_of MT:0000075 ! blood-brain barrier morphology [Term] id: MT:0005168 name: female meiosis namespace: Trait.ontology def: "malfunction in the process of nuclear division that results in ova with one half the normal chromosome number of the original cell" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] xref: GO:0007143 is_a: MT:0001930 ! meiosis is_a: MT:0001931 ! oogenesis [Term] id: MT:0005169 name: male meiosis namespace: Trait.ontology def: "malfunction in the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] xref: GO:0007140 is_a: MT:0001156 ! spermatogenesis is_a: MT:0001930 ! meiosis [Term] id: MT:0005170 name: cleft lip namespace: Trait.ontology def: "defect in the upper lip where the maxillary prominence fails to merge with the merged medial nasal prominences" [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "harelip" EXACT [] is_a: MT:0003769 ! lip morphology [Term] id: MT:0005171 name: lack of coat pigmentation namespace: Trait.ontology def: "fur is devoid of coloration and appears white " [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, J:83500] synonym: "absent coat pigmentation" EXACT [] is_a: MT:0002075 ! coat color [Term] id: MT:0005172 name: lack of eye pigmentation namespace: Trait.ontology def: "visual organs are devoid of coloring pigment in relation to control animals, usually resulting in a red or pink color" [J:83500] synonym: "ocular albinism" EXACT [] is_a: MT:0001324 ! eye pigmentation [Term] id: MT:0005174 name: tail pigmentation namespace: Trait.ontology def: "anomalous color of the tail in relation to control animals" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "tail pigmentation abnormalities" EXACT [] is_a: MT:0002095 ! skin pigmentation is_a: MT:0002111 ! tail morphology [Term] id: MT:0005175 name: non-pigmented tail tip namespace: Trait.ontology def: "lack of color at the end of the tail " [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, J:83500] is_a: MT:0005174 ! tail pigmentation [Term] id: MT:0005176 name: eyelids fail to open namespace: Trait.ontology def: "eyes remain shut throughout life" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, J:83500] synonym: "closed eyes" EXACT [] synonym: "eyelids don't open" EXACT [] synonym: "eyes fail to open" EXACT [] is_a: MT:0003671 ! eyelid opening [Term] id: MT:0005177 name: total circulating cholesterol level namespace: Trait.ontology alt_id: MT:0001549 def: "anomalous concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] subset: slim_chkn synonym: "abnormal total plasma cholesterol level" EXACT [] synonym: "abnormal total serum cholesterol level" EXACT [] is_a: MT:0000180 ! circulating cholesterol level [Term] id: MT:0005180 name: circulating testosterone level namespace: Trait.ontology def: "aberration in the blood concentration of this most potent androgen" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "abnormal circulating level of testosterone" EXACT [] is_a: MT:0005418 ! circulating hormone level [Term] id: MT:0005183 name: circulating estradiol level namespace: Trait.ontology def: "aberration in the blood concentration of this most potent estrogen" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "abnormal circulating level of estradiol" EXACT [] is_a: MT:0003369 ! circulating estrogen level [Term] id: MT:0005184 name: circulating progesterone level namespace: Trait.ontology def: "aberration in the blood concentration of this antiestrogenic steroid" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] subset: slim_cattle subset: slim_chkn synonym: "abnormal circulating level of progesterone" EXACT [] is_a: MT:0005418 ! circulating hormone level [Term] id: MT:0005187 name: penis morphology namespace: Trait.ontology def: "anomalous structure of the organ of copulation and urination in the male" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000516 ! urinary system morphology is_a: MT:0001145 ! male reproductive anatomy [Term] id: MT:0005189 name: anogenital distance namespace: Trait.ontology def: "the measure of the length of space from the genitals to the anus" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "abnormal ano-genital distance" EXACT [] is_a: MT:0003315 ! perineum morphology [Term] id: MT:0005190 name: osteomyelitis namespace: Trait.ontology def: "bone inflammation" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001533 ! skeleton physiology is_a: MT:0001846 ! tissue specific inflammatory response [Term] id: MT:0005193 name: anterior eye segment morphology namespace: Trait.ontology alt_id: MT:0000095 def: "anomalous structure of any of the parts of the eye that lie in front of, or ventral to, the lens (inclusive)" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal anterior segment" EXACT [] is_a: MT:0002092 ! eye morphology [Term] id: MT:0005194 name: anterior uvea morphology namespace: Trait.ontology def: "anomalous structure of any of the parts of the front, or ventral, portion of the vascular, pigmentary, or middle coat of the eye, including the ciliary body and the iris" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "anterior uvea abnormalities" EXACT [] synonym: "Haller tunica vascula abnormalities" EXACT [] synonym: "tunica vasculosa bulbosa abnormalities" EXACT [] synonym: "uveal tract abnormalities" EXACT [] synonym: "vascular layer of the eyeball" EXACT [] synonym: "vascular tunic of the eye" EXACT [] synonym: "vasculosa oculi abnormalities" EXACT [] is_a: MT:0005193 ! anterior eye segment morphology is_a: MT:0005197 ! uvea morphology [Term] id: MT:0005195 name: posterior eye segment morphology namespace: Trait.ontology def: "anomalous structure of any of the parts of the eye that lie in back of, or dorsal to, the lens (but not inclusive)" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "posterior eye segment abnormalities" EXACT [] is_a: MT:0002092 ! eye morphology [Term] id: MT:0005196 name: posterior uvea morphology namespace: Trait.ontology def: "structural anomaly of the rear, or dorsal, portion of the vascular, pigmentary, or middle coat of the eye, includes the choroid" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "posterior uvea abnormalities" EXACT [] synonym: "tunica vasculosa bulbi" EXACT [] synonym: "tunica vasculosa oculi abnormalities" EXACT [] synonym: "uveal tract abnormalities" EXACT [] synonym: "vascular layer of the eyeball" EXACT [] synonym: "vascular tunic of the eye abnormalities" EXACT [] is_a: MT:0002864 ! ocular fundus morphology is_a: MT:0005197 ! uvea morphology [Term] id: MT:0005197 name: uvea morphology namespace: Trait.ontology def: "structural anomaly of the pigmented vascular coat of the eyeball, consisting of the iris, ciliary body, and choroid" [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "uvea abnormalities" EXACT [] synonym: "vascular layer of the eyeball" EXACT [] is_a: MT:0002092 ! eye morphology [Term] id: MT:0005198 name: aqueous drainage system morphology namespace: Trait.ontology def: "anomalies in the structures associated with drainage of the aqueous humor from the eye, these include the trabecular meshwork, Schlemm's canal, the uveoscleral network, and the aqueous veins" [MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0005194 ! anterior uvea morphology [Term] id: MT:0005199 name: iris pigment epithelium namespace: Trait.ontology def: "anomaly in the epithelial layer of the iris composed of cells containing pigment granules" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001322 ! iris morphology is_a: MT:0005200 ! pigment epithelium of the eye [Term] id: MT:0005200 name: pigment epithelium of the eye namespace: Trait.ontology def: "anomaly in the epithelial layer of the retina, ciliary body, or iris composed of cells containing pigment granules" [MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0001324 ! eye pigmentation [Term] id: MT:0005201 name: retinal pigment epithelium morphology namespace: Trait.ontology def: "anomaly in the epithelial layer of the retina composed of cells containing pigment granules" [MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0003727 ! retinal layer morphology is_a: MT:0005200 ! pigment epithelium of the eye [Term] id: MT:0005202 name: level of alertness namespace: Trait.ontology is_a: MT:0003313 ! locomotor activation [Term] id: MT:0005203 name: trabecular meshwork morphology namespace: Trait.ontology def: "structural anomaly in the pore-like structure surrounding the entire circumference of the anterior chamber through which aqueous humor circulates" [MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0004221 ! iridocorneal angle morphology [Term] id: MT:0005204 name: canal of Schlemm morphology namespace: Trait.ontology def: "structural anomaly in the vascular structure encircling the anterior chamber of the eye, through which the aqueous humor is returned to the blood circulation" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "circular sinus abnormalities" EXACT [] synonym: "Fontana canal abnormalities" EXACT [] synonym: "Lauth canal abnormalities" EXACT [] synonym: "Schlemm's canal" EXACT [] synonym: "scleral venous sinus abnormalities" EXACT [] synonym: "sinus circularis abnormalities" EXACT [] synonym: "sinus venosus sclerae abnormalities" EXACT [] synonym: "venous sinus of sclera abnormalities" EXACT [] is_a: MT:0004221 ! iridocorneal angle morphology [Term] id: MT:0005205 name: eye anterior chamber namespace: Trait.ontology def: "anomaly of the space in the eye, filled with aqueous humor, and bounded anteriorly by the cornea and a small portion of the sclera and posteriorly by a small portion of the ciliary body, the iris, and part of the crystalline lens" [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "eye anterior chamber abnormalities" EXACT [] is_a: MT:0005193 ! anterior eye segment morphology [Term] id: MT:0005206 name: aqueous humor morphology namespace: Trait.ontology def: "anomaly in the clear, watery fluid that fills the anterior and posterior chambers of the eye" [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "aqueous humor abnormalities" EXACT [] is_a: MT:0005205 ! eye anterior chamber [Term] id: MT:0005207 name: aqueous vein morphology namespace: Trait.ontology def: "structural anomaly of this vessel that receives aqueous humor from the sinus venosus sclerae (canal of Schlemm)" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0004221 ! iridocorneal angle morphology [Term] id: MT:0005208 name: iris stroma morphology namespace: Trait.ontology def: "structural anomaly of the lamellated connective tissue of the iris" [MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0001322 ! iris morphology [Term] id: MT:0005209 name: gastric mucosa morphology namespace: Trait.ontology def: "anomaly of the surface epithelium of the stomach, which is made up of several different cell types " [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal gastric mucosa" EXACT [] is_a: MT:0000473 ! stomach glandular epithelium morphology [Term] id: MT:0005211 name: thickness of gastric mucosa namespace: Trait.ontology def: "depth or width of the epithelial layer of the stomach" [J:77398, MeSH:National Library of Medicine_Medical Subject Headings] synonym: "expanded mucosal thickness of the stomach" EXACT [] is_a: MT:0005209 ! gastric mucosa morphology [Term] id: MT:0005212 name: immature goblet-like cells in stomach namespace: Trait.ontology def: "unusual appearance of stomach mucosa in which one finds cells resembling those that produce and secrete mucins" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, J:77398] is_a: MT:0005209 ! gastric mucosa morphology [Term] id: MT:0005213 name: gastric metaplasia namespace: Trait.ontology def: "condition in which there is a change of one adult cell type to another adult cell type in the stomach " [J:77398, MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0005209 ! gastric mucosa morphology [Term] id: MT:0005214 name: regional gastric metaplasia namespace: Trait.ontology def: "localized areas of the stomach in which there is a change from one adult cell type to another adult cell type" [J:77398, MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0005213 ! gastric metaplasia [Term] id: MT:0005215 name: islet of Langerhans morphology namespace: Trait.ontology alt_id: MT:0001946 alt_id: MT:0005219 def: "anomalous morphology of these structures that are scattered throughout the pancreas and comprise its endocrine portion; within each islet there are three cell types: alpha, beta, and delta" [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal endocrine pancreas" EXACT [] synonym: "abnormal islet of Langerhans" EXACT [] synonym: "beta cell abnormalities" EXACT [] synonym: "islet cell abnormalities" EXACT [] is_a: MT:0001944 ! pancreas morphology [Term] id: MT:0005216 name: pancreatic alpha cell morphology namespace: Trait.ontology def: "malformation of the cells of the pancreas that secrete glucagon" [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal pancreatic alpha cells" EXACT [] is_a: MT:0005215 ! islet of Langerhans morphology [Term] id: MT:0005217 name: pancreatic beta cell morphology namespace: Trait.ontology def: "malformation of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal pancreatic beta cells" EXACT [] is_a: MT:0005215 ! islet of Langerhans morphology [Term] id: MT:0005218 name: pancreatic delta cell morphology namespace: Trait.ontology def: "malformation of the cells found in the pancreas and gastrointestinal tract that secrete somatostatin" [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal D cells" EXACT [] synonym: "abnormal pancreatic delta cells" EXACT [] is_a: MT:0005215 ! islet of Langerhans morphology [Term] id: MT:0005220 name: exocrine pancreas morphology namespace: Trait.ontology def: "malformation of the acinar gland portion of the pancreas that secretes digestive enzymes " [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal exocrine pancreas" EXACT [] is_a: MT:0001944 ! pancreas morphology [Term] id: MT:0005221 name: rostral-caudal axis patterning namespace: Trait.ontology alt_id: MT:0001703 def: "anomaly in the development or formation of the axis that runs from the head to the tail of the body" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "abnormal anterior-posterior axis patterning" EXACT [] synonym: "abnormal head-tail axis patterning" EXACT [] synonym: "abnormal rostro-caudal axis patterning" EXACT [] is_a: MT:0002084 ! developmental patterning [Term] id: MT:0005222 name: somite size namespace: Trait.ontology def: "atypical size of any of the segmental masses along the notochord of the developing embryo" [J:72325] synonym: "irregular somite size" EXACT [] is_a: MT:0001688 ! somite development [Term] id: MT:0005223 name: anterior-posterior polarity of the somites namespace: Trait.ontology def: "anomalous development or formation of the somites along the axis that runs from the front to the back surface of the body" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, J:72325] is_a: MT:0001688 ! somite development is_a: MT:0005221 ! rostral-caudal axis patterning [Term] id: MT:0005224 name: left-right axis symmetry of the somites namespace: Trait.ontology def: "anomaly in the formation or development of the somites in relation to the left and right sides of the body " [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "left-right asymmetry" EXACT [] is_a: MT:0001688 ! somite development is_a: MT:0001706 ! left-right axis patterning [Term] id: MT:0005225 name: vertebrae development namespace: Trait.ontology def: "anomalous formation of the vertebrae from the sclerotome" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] is_a: MT:0000137 ! vertebrae morphology is_a: MT:0002113 ! skeleton development [Term] id: MT:0005226 name: vertebral arch development namespace: Trait.ontology def: "anomalous formation of the posterior projection from the body of a vertebra that encloses the vertebral foramen " [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0005225 ! vertebrae development [Term] id: MT:0005227 name: vertebral body development namespace: Trait.ontology def: "anomalous formation of the main portion of the vertebra anterior to the vertebral canal, and distinct from the vertebral arch" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0005225 ! vertebrae development [Term] id: MT:0005228 name: fusion of vertebral bodies/neural arches namespace: Trait.ontology def: "improper joining of the main portion of the vertebra anterior to the vertebral canal and the cartilaginous or bony arch that encloses and protects the spinal cord on the back" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "vertebral body/neural arch fusion" EXACT [] is_a: MT:0005227 ! vertebral body development [Term] id: MT:0005229 name: intervertebral disk development namespace: Trait.ontology def: "anomalous formation of the cartilaginous and gelatinous structure found between vertebrae" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "abnormal intervertebral disc formation" EXACT [] synonym: "abnormal intervertebral disk formation" EXACT [] is_a: MT:0000164 ! cartilage development is_a: MT:0005225 ! vertebrae development [Term] id: MT:0005230 name: ectrodactyly namespace: Trait.ontology def: "absence of the middle rays, i.e., the central digits of the paws; usually associated with cleft paws and may also include syndactyly or aplasia of remaining digits" [OMIM:Online Mendelian Inheritance in Man] is_a: MT:0002110 ! digit morphology [Term] id: MT:0005231 name: brachial lymph node morphology namespace: Trait.ontology def: "anomalous structure, development, or number of the lymph nodes located along the brachial vein that receive drainage from most of the free upper limb and send efferent vessels to the central axillary lymph nodes" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "brachial lymph node abnormalities" EXACT [] synonym: "humeral axillary lymph node abnormalities" EXACT [] is_a: MT:0002340 ! axillary lymph node morphology [Term] id: MT:0005232 name: mesenteric lymph node morphology namespace: Trait.ontology def: "anomalous structure, development, or number of the lymph nodes located in the mesentary, of which there are 3 classes: ileocolic, juxtaintestinal mesenteric, and central superior group" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "mesenteric lymph node abnormalities" EXACT [] is_a: MT:0002339 ! lymph node morphology [Term] id: MT:0005233 name: plasmacytoma namespace: Trait.ontology def: "discrete, presumably solitary mass of neoplastic plasma cells in bone or in one of the extramedullary sites" [J:78204, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002019 ! tumor incidence [Term] id: MT:0005234 name: thymic lymphoma namespace: Trait.ontology alt_id: MT:0003832 def: "a neoplasm originating from thymic tissue, usually benign, and frequently encapsulated" [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "thymoma" EXACT [] is_a: MT:0002019 ! tumor incidence is_a: MT:0002022 ! lymphoma [Term] id: MT:0005235 name: olfactory pathway morphology namespace: Trait.ontology def: "anomalous structure of any of the set of nerve fibers conducting impulses from olfactory receptors to the cerebral cortex, including the olfactory nerve; olfactory bulb; olfactory tract, olfactory tubercle, anterior perforated substance, and olfactory cortex" [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal olfactory pathways" EXACT [] is_a: MT:0000787 ! telencephalon morphology [Term] id: MT:0005236 name: olfactory nerve morphology namespace: Trait.ontology alt_id: MT:0001057 def: "anomalous structure of the first cranial nerve, which conveys the sense of smell" [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal olfactory nerve" EXACT [] synonym: "CN-I" EXACT [] synonym: "olfactory nerve abnormalities" EXACT [] is_a: MT:0001056 ! cranial nerve morphology is_a: MT:0005235 ! olfactory pathway morphology [Term] id: MT:0005237 name: olfactory tract morphology namespace: Trait.ontology def: "structural anomaly of the nerve-like, white band composed primarily of nerve fibers originating from the mitral cells and tufted cells of the olfactory bulb, but also containing the scattered cells of the anterior olfactory nucleus" [J:34460, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal olfactory tract" EXACT [] is_a: MT:0005235 ! olfactory pathway morphology [Term] id: MT:0005239 name: Bruch membrane morphology namespace: Trait.ontology def: "anomalous structure of the transparent, nearly structureless inner layer of the choroid in contact with the pigmented layer of the retina" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "basal lamina of the choroid abnormalities" EXACT [] synonym: "basal layer of the choroid abnormalities" EXACT [] synonym: "Bruch's membrane abnormalities" EXACT [] synonym: "Henle membrane abnormalities" EXACT [] synonym: "lamina basalis choroidae abnormalities" EXACT [] synonym: "lamina vitrea abnormalities" EXACT [] synonym: "vitreous lamella abnormalities" EXACT [] is_a: MT:0005098 ! choroid morphology [Term] id: MT:0005240 name: amacrine cell morphology namespace: Trait.ontology def: "anomalous structure of the interneurons of the retina" [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal amacrine cells" EXACT [] is_a: MT:0000965 ! sensory neuron morphology is_a: MT:0001325 ! retina morphology [Term] id: MT:0005241 name: retinal ganglion layer morphology namespace: Trait.ontology def: "anomalous structure of the innermost nuclear layer of the retina, which projects axons through the optic nerve to the brain" [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal retinal ganglion cell morphology" EXACT [] synonym: "abnormal retinal ganglion cells" EXACT [] is_a: MT:0006069 ! retinal neuronal layer morphology [Term] id: MT:0005245 name: hemarthrosis namespace: Trait.ontology def: "bleeding into a joint space" [Pathology:ISBN 0-397-51047-0] is_a: MT:0002932 ! joint morphology [Term] id: MT:0005246 name: orbit morphology namespace: Trait.ontology def: "structural anomaly of the contents of the bony cavity that contains the eyeball or of any of the parts of eight bones in the mouse which form the cavity" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal orbit" EXACT [] synonym: "orbit abnormalities" EXACT [] is_a: MT:0002092 ! eye morphology [Term] id: MT:0005247 name: extraocular muscle morphology namespace: Trait.ontology def: "structural anomaly of any of the striated muscles that move the eye and include: superior rectus, inferior rectus, medial rectus, lateral rectus, superior oblique, inferior oblique, retractor bulbi" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] is_a: MT:0000759 ! skeletal muscle morphology is_a: MT:0003686 ! eye muscle morphology [Term] id: MT:0005248 name: Harderian gland morphology namespace: Trait.ontology def: "structural anomaly of the sebaceous gland located behind the eyeball in the orbit that excretes fluid that facilitates movement of the third eyelid" [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "Harderian gland abnormalities" EXACT [] is_a: MT:0002163 ! gland morphology is_a: MT:0005246 ! orbit morphology [Term] id: MT:0005249 name: palatine bone morphology namespace: Trait.ontology def: "any structural anomaly of either of two irregularly shaped bones that form the back of the hard palate and helps to form the nasal cavity and the floor of the orbits" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal hard palate" EXACT [] synonym: "abnormal palatine bone" EXACT [] is_a: MT:0005274 ! viscerocranium morphology is_a: MT:0005552 ! orbital bone morphology [Term] id: MT:0005250 name: Sertoli cell number namespace: Trait.ontology def: "decreased number of cells of the seminiferous tubules that create the blood-testes barrier and enable spermatogenesis" [J:70212, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "decreased sertoli cell number" EXACT [] is_a: MT:0001940 ! testicular cell number is_a: MT:0002784 ! Sertoli cell morphology is_a: MT:0004109 ! Sertoli cell development [Term] id: MT:0005251 name: blepharitis namespace: Trait.ontology def: "inflammation of the eyelids" [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "inflamed eyelids" EXACT [] is_a: MT:0001340 ! eyelid morphology is_a: MT:0001851 ! eye inflammation [Term] id: MT:0005252 name: meibomian gland morphology namespace: Trait.ontology def: "structural anomaly of the sebaceous glands embedded in the tarsal plate of each eyelid" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001340 ! eyelid morphology is_a: MT:0002163 ! gland morphology [Term] id: MT:0005253 name: eye physiology namespace: Trait.ontology def: "anomalous function and/or activity of the ocular system or any of its parts" [MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0005391 ! vision/eye trait [Term] id: MT:0005254 name: strabismus namespace: Trait.ontology def: "misalignment of the visual axes of the eyes" [MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0002092 ! eye morphology [Term] id: MT:0005255 name: exotropia namespace: Trait.ontology def: "a form of ocular misalignment in which the lateral rectus muscle pulls the eye in an outward direction" [MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0005254 ! strabismus [Term] id: MT:0005256 name: esotropia namespace: Trait.ontology def: "a form of ocular misalignment in which there is excessive convergence of the visual axes, giving a cross-eyed appearance" [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "cross eyed" EXACT [] is_a: MT:0005254 ! strabismus [Term] id: MT:0005257 name: intraocular pressure namespace: Trait.ontology def: "anomaly in the amount of force per unit area exerted by the intraocular fluid within the eye" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0005253 ! eye physiology [Term] id: MT:0005261 name: aniridia namespace: Trait.ontology def: "abnormality in which there is only a rudimentary iris, due to the failure of optic cup growth" [MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0001286 ! eye development [Term] id: MT:0005262 name: coloboma namespace: Trait.ontology def: "anomaly in which some of the structures of the eye are absent due to incomplete fusion of the fetal intraocular fissure during gestation" [MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0001286 ! eye development [Term] id: MT:0005263 name: ectopia lentis namespace: Trait.ontology def: "congenital displacement of the lens due to defective zonule formation" [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "lens displacement" EXACT [] is_a: MT:0001286 ! eye development is_a: MT:0001303 ! lens morphology [Term] id: MT:0005264 name: glomerulosclerosis namespace: Trait.ontology def: "hyaline deposits or scarring within the renal glomeruli, often occurring with renal arteriosclerosis or diabetes" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "glomerular sclerosis" EXACT [] is_a: MT:0000523 ! cortical glomerulopathies [Term] id: MT:0005265 name: blood urea nitrogen level namespace: Trait.ontology def: "aberrant circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal blood urea nitrogen" EXACT [] synonym: "abnormal BUN" EXACT [] is_a: MT:0000179 ! blood chemistry [Term] id: MT:0005267 name: olfactory cortex morphology namespace: Trait.ontology def: "anomalous structure of piriform cortex, part of the olfactory tract, which receives its major afferents from the olfactory bulb, and is primarily responsible for the identification of odors" [J:83884, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal olfactory cortex" EXACT [] synonym: "abnormal piriform area" EXACT [] synonym: "abnormal piriform cortex" EXACT [] is_a: MT:0005235 ! olfactory pathway morphology [Term] id: MT:0005269 name: occipital bone morphology namespace: Trait.ontology def: "anomalous structure of the bone at the lower, posterior part of the skull" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal occipital bone" EXACT [] is_a: MT:0000076 ! calvaria morphology is_a: MT:0005273 ! cranial base morphology [Term] id: MT:0005270 name: zygomatic bone morphology namespace: Trait.ontology def: "any structural anomaly of the quadrilateral bone that forms the prominence of the cheek" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal cheek bone" EXACT [] synonym: "abnormal jugal bone" EXACT [] synonym: "abnormal malar bone" EXACT [] synonym: "abnormal yoke bone" EXACT [] synonym: "abnormal zygomatic bone" EXACT [] is_a: MT:0005274 ! viscerocranium morphology is_a: MT:0005552 ! orbital bone morphology [Term] id: MT:0005271 name: lacrimal bone morphology namespace: Trait.ontology def: "anomalous structure of the irregularly thin plate that forms part of the medial wall of the orbit behind the frontal process of the maxilla" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal lacrimal bone" EXACT [] is_a: MT:0005274 ! viscerocranium morphology is_a: MT:0005552 ! orbital bone morphology [Term] id: MT:0005272 name: temporal bone morphology namespace: Trait.ontology def: "anomalous structure of the large, irregular bone located at the base and side of the skull; consists of three parts at birth: squamous, tympanic, and petrous" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal squamosal bone" EXACT [] synonym: "abnormal temporal bone" EXACT [] is_a: MT:0000076 ! calvaria morphology is_a: MT:0005552 ! orbital bone morphology [Term] id: MT:0005273 name: cranial base morphology namespace: Trait.ontology def: "anomalous structure or formation of the bones that form the floor of the cranial cavity" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "abnormal base of skull" EXACT [] synonym: "abnormal basicranium morphology" EXACT [] synonym: "abnormal basis cranii" RELATED [] synonym: "abnormal cranial base" EXACT [] is_a: MT:0000074 ! neurocranium morphology [Term] id: MT:0005274 name: viscerocranium morphology namespace: Trait.ontology def: "anomalous structure or formation of the part of the skull that comprises the facial bones " [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal facial bones" EXACT [] synonym: "abnormal viscerocranium" EXACT [] is_a: MT:0000438 ! skull morphology [Term] id: MT:0005275 name: skin tensile strength namespace: Trait.ontology def: "change from the normal maximum tension the skin can withstand without tearing" [J:84062, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001191 ! skin condition [Term] id: MT:0005276 name: skin tumor namespace: Trait.ontology def: "presence of abnormal rapidly proliferating cells in the dermis and/or epidermis, usually in the form of a distinct mass" [J:73649, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001191 ! skin condition is_a: MT:0002019 ! tumor incidence [Term] id: MT:0005277 name: brainstem morphology namespace: Trait.ontology def: "anomalous structure of the midbrain, pons, or medulla" [J:82670, pvb:Pierre Vanden Borre_Mouse Genome Informatics Curator] synonym: "abnormal brain stem" EXACT [] synonym: "abnormal brainstem" EXACT [] is_a: MT:0002152 ! brain morphology [Term] id: MT:0005278 name: cholesterol homeostasis namespace: Trait.ontology def: "anomaly in the state of equilibrium in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [J:71350, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] subset: slim_chkn subset: slim_pig is_a: MT:0002118 ! lipid homeostasis [Term] id: MT:0005280 name: fatty acid level namespace: Trait.ontology def: "anomalous concentration of organic, monobasic acids derived from hydrocarbons and which are complexed with serum albumin for transport; they are saturated and unsaturated" [MeSH:National Library of Medicine_Medical Subject Headings] subset: slim_cattle subset: slim_pig is_a: MT:0001547 ! lipid level relationship: part_of MT:0005666 ! adipose tissue physiology [Term] id: MT:0005285 name: unsaturated fatty acid level namespace: Trait.ontology def: "less than normal non-circulating level of organic, monobasic acids derived from hydrocarbons in which the carbon chain has one or more double or triple carbon-carbon bonds" [MeSH:National Library of Medicine_Medical Subject Headings] subset: slim_pig synonym: "lowered unsaturated fatty acid level" EXACT [] is_a: MT:0005280 ! fatty acid level [Term] id: MT:0005286 name: saturated fatty acid level namespace: Trait.ontology def: "less than normal non-circulating level of organic, monobasic acids derived from hydrocarbons in which the carbon chain contains only single carbon-carbon bonds" [MeSH:National Library of Medicine_Medical Subject Headings] subset: slim_pig synonym: "lowered saturated fatty acid level" EXACT [] is_a: MT:0005280 ! fatty acid level [Term] id: MT:0005288 name: oxygen consumption rate namespace: Trait.ontology def: "deviation from the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal metabolic rate" EXACT [] is_a: MT:0003948 ! gas homeostasis [Term] id: MT:0005291 name: glucose tolerance namespace: Trait.ontology def: "deviation from the normal response to oral consumption or intravenous injection of specified amounts of glucose; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0002078 ! glucose homeostasis [Term] id: MT:0005294 name: heart ventricle morphology namespace: Trait.ontology def: "any measurable or observable characteristic related to the shape, structure, color or pattern of the lower chamber(s) of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] subset: slim_chkn synonym: "cardiac ventricle morphology" RELATED [] synonym: "cardiac ventricular morphology" RELATED [] synonym: "heart ventricular morphology" EXACT [] relationship: part_of MT:0000266 ! cardiac morphology [Term] id: MT:0005295 name: left ventricle integrity namespace: Trait.ontology def: "any measurable characteristic pertaining to the the structural completeness or structural soundness of the left lower chamber of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] relationship: part_of MT:0000053 ! heart integrity relationship: part_of MT:0003921 ! left ventricle morphology [Term] id: MT:0005296 name: humerus morphology namespace: Trait.ontology def: "malformation of the bone of the forelimb that articulates with the scapula above and the radius and ulna below" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] subset: slim_chkn synonym: "abnormal humerus" EXACT [] is_a: MT:0003723 ! long bone morphology [Term] id: MT:0005297 name: spina bifida occulta namespace: Trait.ontology def: "common congenital midline defect of fusion of the vertebral arch without protrusion of the spinal cord or meninges" [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "closed spinal bifida" EXACT [] synonym: "occult spina bifida" EXACT [] is_a: MT:0003054 ! spina bifida [Term] id: MT:0005298 name: clavicle morphology namespace: Trait.ontology def: "malformation of the doubly curved long bone that forms part of the shoulder girdle and articulates with the sternum and the scapula" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal clavicle" EXACT [] synonym: "abnormal collar bone" EXACT [] is_a: MT:0000148 ! shoulder/ pelvic girdle morphology [Term] id: MT:0005299 name: eye posterior chamber namespace: Trait.ontology def: "anomaly of the ring-like space, filled with aqueous humor, between the iris/pupil anteriorly and the lens and ciliary body posteriorly" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "eye posterior chamber abnormalities" EXACT [] is_a: MT:0005193 ! anterior eye segment morphology [Term] id: MT:0005300 name: corneal stroma morphology namespace: Trait.ontology def: "structural anomaly of the lamellated connective tissue of the cornea" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001312 ! cornea morphology [Term] id: MT:0005301 name: corneal endothelium morphology namespace: Trait.ontology def: "anomalous structure of the single layer of large flattened cells that cover the surface of the cornea" [MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0001312 ! cornea morphology [Term] id: MT:0005302 name: neurogenic bladder namespace: Trait.ontology def: "defective functioning of the bladder due to impaired innervation, either within the CNS or the PNS" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "neuropathic bladder" EXACT [] is_a: MT:0002184 ! innervation is_a: MT:0005303 ! urinary bladder physiology [Term] id: MT:0005303 name: urinary bladder physiology namespace: Trait.ontology def: "abnormal working of the inflatable musculomembranous bag for holding urine" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "urinary bladder dysfunction" EXACT [] is_a: MT:0001756 ! urination [Term] id: MT:0005304 name: cystic bulbourethral gland namespace: Trait.ontology def: "presence of membrane-lined sacs containing gas, fluid, or semisolid matter in the gland in males that lies along the prostate gland and secretes a fluid component of the seminal fluid into the urethra" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "cystic Cowper's gland" EXACT [] is_a: MT:0001169 ! bulbourethral gland morphology [Term] id: MT:0005305 name: coagulating gland size namespace: Trait.ontology def: "increased number of normal cells in the anterior lobe of the prostate" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "hyperplastic coagulating gland" EXACT [] is_a: MT:0001163 ! coagulating gland morphology [Term] id: MT:0005306 name: phalanx morphology namespace: Trait.ontology def: "aberrant structure of any of the long bones of the digits" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal phalanges" EXACT [] synonym: "abnormal phalanxes" EXACT [] is_a: MT:0002115 ! skeleton extremities morphology [Term] id: MT:0005308 name: circulating ammonia level namespace: Trait.ontology def: "aberrant concentration in the blood of this colorless alkaline gas, formed in the body during organic decomposition" [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal ammonia level" EXACT [] is_a: MT:0000179 ! blood chemistry [Term] id: MT:0005310 name: salivary gland physiology namespace: Trait.ontology def: "anomalous function of any of the glands in the mouth that secrete saliva" [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal salivary gland function" EXACT [] is_a: MT:0001663 ! digestive system physiology is_a: MT:0002164 ! gland physiology [Term] id: MT:0005311 name: circulating amino acid level namespace: Trait.ontology def: "aberrant concentration in the blood of these organic compounds, which, when polymerized, form proteins" [J:83263, MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal blood amino acid level" EXACT [] is_a: MT:0000179 ! blood chemistry is_a: MT:0005332 ! amino acid level [Term] id: MT:0005316 name: response to tactile stimuli namespace: Trait.ontology is_a: MT:0002734 ! mechanical nociception [Term] id: MT:0005319 name: enzyme/ coenzyme level namespace: Trait.ontology def: "altered concentration of any of these proteins, or their cofactors, that act as catalysts to induce chemical changes in other substances" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] subset: slim_chkn subset: slim_pig is_a: MT:0001764 ! homeostasis [Term] id: MT:0005320 name: biopterin level namespace: Trait.ontology def: "anomalous concentration of this pterin found in yeast, the fruit fly and in normal human urine, the reduced form of which acts as a coenzyme for many enzymatic reactions" [J:84533, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0005319 ! enzyme/ coenzyme level [Term] id: MT:0005321 name: neopterin level namespace: Trait.ontology def: "anomalous concentration of this pteridine derivative, which is present in body fluids and is a precursor in the biosynthesis of biopterin; elevated levels result from immune activation, malignant disease, allograft rejection, and viral infection" [J:84533, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0005320 ! biopterin level [Term] id: MT:0005322 name: serotonin level namespace: Trait.ontology def: "anomalous concentration of biochemical messenger and regulator, found in the CNS, gastrointestinal tract, and produced by platelets; it mediates neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity" [ISBN:0-683-40008-8 "Stedman's Medical Dictionary, 27th edition"] synonym: "5-HT level" EXACT [] is_a: MT:0002504 ! serotonin activity [Term] id: MT:0005324 name: ascites namespace: Trait.ontology def: "accumulation or retention of fluid within the peritoneal cavity" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001784 ! fluid regulation [Term] id: MT:0005325 name: glomerulus morphology namespace: Trait.ontology def: "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, J:57971] synonym: "abnormal glomerular capillaries" EXACT [] synonym: "abnormal glomeruli" EXACT [] is_a: MT:0002827 ! renal corpuscle morphology [Term] id: MT:0005326 name: podocyte morphology namespace: Trait.ontology def: "anomalous structure of the foot processes of the epithelial cells of the glomerulus" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, J:57971] synonym: "abnormal glomerular epithelial cells" EXACT [] is_a: MT:0005325 ! glomerulus morphology [Term] id: MT:0005327 name: mesangial cell morphology namespace: Trait.ontology def: "anomalous structure of the phagocytic cell in the capillary tuft of the renal glomerulus, interposed between endothelial cells and the basement membrane in the central or stalk region of the tuft" [J:57971, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal deep cell" EXACT [] synonym: "abnormal intercapillary cell" EXACT [] is_a: MT:0005325 ! glomerulus morphology [Term] id: MT:0005328 name: circulating creatinine level namespace: Trait.ontology def: "anomalous blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal creatinine level" EXACT [] is_a: MT:0000179 ! blood chemistry [Term] id: MT:0005329 name: heart muscle morphology namespace: Trait.ontology def: "any measurable or observable characteristic related to the shape, structure, color or pattern of the involuntary muscle comprising the myocardium" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] synonym: "cardiac muscle morphology" RELATED [] synonym: "myocardial morphology" RELATED [] xref: MP:0005329 is_a: MT:0002108 ! muscle morphology relationship: part_of MT:0000266 ! cardiac morphology [Term] id: MT:0005332 name: amino acid level namespace: Trait.ontology def: "aberrant concentration of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0001764 ! homeostasis [Term] id: MT:0005334 name: fat pad morphology namespace: Trait.ontology def: "any measurable or observable characteristic related to the shape, structure, color or pattern of the encapsulated adipose tissue" [CP:Cari Park_Iowa State University curator] subset: slim_chkn is_a: MT:0000003 ! adipose tissue morphology [Term] id: MT:0005335 name: gonadal fat pad morphology namespace: Trait.ontology is_a: MT:0005334 ! fat pad morphology [Term] id: MT:0005336 name: inguinal fat pad morphology namespace: Trait.ontology is_a: MT:0005334 ! fat pad morphology [Term] id: MT:0005337 name: retroperitoneal fat pad morphology namespace: Trait.ontology is_a: MT:0005334 ! fat pad morphology [Term] id: MT:0005342 name: lipid absorption namespace: Trait.ontology def: "anomalous ability of the body to take in fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water" [J:85204, pvb:Pierre Vanden Borre_Mouse Genome Informatics Curator] is_a: MT:0001666 ! nutrient absorption is_a: MT:0002118 ! lipid homeostasis [Term] id: MT:0005345 name: circulating corticosterone level namespace: Trait.ontology def: "anomalous blood concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] subset: slim_chkn synonym: "abnormal serum level of corticosterone" EXACT [] is_a: MT:0003366 ! circulating glucocorticoid level is_a: MT:0003963 ! corticosterone level [Term] id: MT:0005346 name: circulating aldosterone level namespace: Trait.ontology def: "anomalous blood concentration of this hormone, secreted by the adrenal cortex, in the bloodstream; regulates sodium conservation and potassium secretion in the distal renal tubule" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal serum level of aldosterone" EXACT [] is_a: MT:0005418 ! circulating hormone level [Term] id: MT:0005349 name: IL-6 physiology namespace: Trait.ontology def: "functional anomaly of this soluble factor produced by B- and T-cells, with effects on T- and B-cell growth and differentiation, and in acute phase reactions" [Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] is_a: MT:0002529 ! interleukin physiology [Term] id: MT:0005353 name: patella morphology namespace: Trait.ontology def: "anomalous structure of the large sesamoid bone that covers the anterior surface of the knee" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, J:47316, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal kneecap" EXACT [] synonym: "abnormal patella" EXACT [] is_a: MT:0002115 ! skeleton extremities morphology [Term] id: MT:0005354 name: ilium morphology namespace: Trait.ontology def: "structural anomaly of the broad, flaring portion of the hip bone, which is distinct at birth, but later fuses with the ischium and the pubis " [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, J:47316, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal iliac bone" EXACT [] synonym: "abnormal ilium" EXACT [] is_a: MT:0000148 ! shoulder/ pelvic girdle morphology [Term] id: MT:0005355 name: thyroid gland size namespace: Trait.ontology def: "increased size of the endocrine gland located in the front and to the sides of the upper part of the trachea, and which secretes thyroid hormone and calcitonin " [J:85158, pvb:Pierre Vanden Borre_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000681 ! thyroid gland morphology [Term] id: MT:0005357 name: locomotor activation in a new environment namespace: Trait.ontology subset: slim_pig synonym: "locomotion" RELATED [] is_a: MT:0001413 ! response to new environment is_a: MT:0003313 ! locomotor activation [Term] id: MT:0005358 name: incisor morphology namespace: Trait.ontology def: "structural defect of the long pointed teeth; most anterior and prominent in the jaw" [J:85574, pvb:Pierre Vanden Borre_Mouse Genome Informatics Curator] synonym: "abnormal incisors" EXACT [] is_a: MT:0002100 ! tooth morphology [Term] id: MT:0005359 name: growth of incisors namespace: Trait.ontology def: "developmental delay of the growth of the incisors, the long pointed teeth, most anterior and prominent in the jaw " [J:85574, pvb:Pierre Vanden Borre_Mouse Genome Informatics Curator] is_a: MT:0000116 ! tooth development [Term] id: MT:0005360 name: urolithiasis namespace: Trait.ontology def: "presence of calculi in any part of the urinary system" [J:85461, J:85462, pvb:Pierre Vanden Borre_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0005502 ! urinary system physiology [Term] id: MT:0005361 name: pituitary gland size namespace: Trait.ontology def: "reduced size of the pituitary gland, the compound gland suspended from the base of the hypothalamus, which secretes somatotropins, prolactin, TSH (thyroid-stimulating hormone), gonadotropins, adrenal corticotropin" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] is_a: MT:0000633 ! pituitary gland morphology [Term] id: MT:0005362 name: Langerhans cell physiology namespace: Trait.ontology def: "atypical or failure of normal function of the phagocytic dendritic cells principally found in the epidermis" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] synonym: "abnormal Langerhans cell function" EXACT [] is_a: MT:0002376 ! dendritic cell physiology [Term] id: MT:0005363 name: susceptibility to prion infection namespace: Trait.ontology alt_id: MT:0003003 def: "reduced likelihood that an organism will develop ill effects from the small proteinaceous infectious particles which are resistant to inactivation by procedures that modify nucleic acids and which contain an abnormal isoform of a cellular protein that is a major and necessary component" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] synonym: "resistance to prion infection" EXACT [] is_a: MT:0001793 ! susceptibility to infection [Term] id: MT:0005365 name: bile salt homeostasis namespace: Trait.ontology def: "anomalous regulation of the steroid salts derived from cholesterol in the liver and which play an important role in the digestion and absorption of fats" [J:86154, MeSH:National Library of Medicine_Medical Subject Headings, pvb:Pierre Vanden Borre_Mouse Genome Informatics Curator] is_a: MT:0001764 ! homeostasis [Term] id: MT:0005366 name: variegated coat color namespace: Trait.ontology def: "dappled coloration of the fur; mosaic" [llw2:Linda Washburn_Mouse Genome Informatics Curator] synonym: "variegated or mosaic" EXACT [] is_a: MT:0000372 ! irregular coat pigmentation [Term] id: MT:0005367 name: renal/urinary system trait namespace: Trait.ontology synonym: "kidney" EXACT [] is_a: MT:0000001 ! Trait [Term] id: MT:0005369 name: muscle trait namespace: Trait.ontology subset: slim_cattle subset: slim_chkn subset: slim_pig is_a: MT:0000001 ! Trait [Term] id: MT:0005370 name: liver/biliary system trait namespace: Trait.ontology subset: slim_chkn subset: slim_pig synonym: "hepatic" EXACT [] is_a: MT:0000001 ! Trait [Term] id: MT:0005371 name: limbs/digits/tail trait namespace: Trait.ontology subset: slim_cattle subset: slim_chkn subset: slim_pig is_a: MT:0000001 ! Trait [Term] id: MT:0005372 name: life span/aging trait namespace: Trait.ontology subset: slim_cattle subset: slim_pig synonym: "lifespan" EXACT [] synonym: "survival" EXACT [] synonym: "viability" EXACT [] synonym: "viable" EXACT [] is_a: MT:0000001 ! Trait [Term] id: MT:0005375 name: adipose tissue trait namespace: Trait.ontology subset: slim_cattle subset: slim_chkn subset: slim_pig synonym: "fat" EXACT [] is_a: MT:0000001 ! Trait [Term] id: MT:0005376 name: homeostasis/metabolism trait namespace: Trait.ontology subset: slim_cattle subset: slim_chkn subset: slim_pig is_a: MT:0000001 ! Trait [Term] id: MT:0005377 name: hearing/vestibular/ear trait namespace: Trait.ontology is_a: MT:0000001 ! Trait [Term] id: MT:0005378 name: growth/size trait namespace: Trait.ontology subset: slim_cattle subset: slim_chkn subset: slim_pig is_a: MT:0000001 ! Trait [Term] id: MT:0005379 name: endocrine/exocrine gland trait namespace: Trait.ontology subset: slim_cattle subset: slim_pig is_a: MT:0000001 ! Trait [Term] id: MT:0005380 name: embryogenesis trait namespace: Trait.ontology is_a: MT:0000001 ! Trait [Term] id: MT:0005381 name: digestive/alimentary trait namespace: Trait.ontology subset: slim_chkn subset: slim_pig synonym: "gastrointestinal" EXACT [] is_a: MT:0000001 ! Trait [Term] id: MT:0005382 name: craniofacial trait namespace: Trait.ontology subset: slim_pig is_a: MT:0000001 ! Trait [Term] id: MT:0005384 name: cellular trait namespace: Trait.ontology synonym: "cell" EXACT [] is_a: MT:0000001 ! Trait [Term] id: MT:0005385 name: cardiovascular system trait namespace: Trait.ontology def: "any measurable or observable characterisitic of the heart and/or vasculature" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] subset: slim_chkn subset: slim_pig synonym: "cardiac" EXACT [] synonym: "circulatory" EXACT [] synonym: "heart" EXACT [] is_a: MT:0000001 ! Trait [Term] id: MT:0005386 name: behavior/neurological trait namespace: Trait.ontology alt_id: MT:0001350 subset: slim_cattle subset: slim_chkn subset: slim_pig is_a: MT:0000001 ! Trait [Term] id: MT:0005387 name: immune system trait namespace: Trait.ontology subset: slim_cattle subset: slim_chkn subset: slim_pig is_a: MT:0000001 ! Trait [Term] id: MT:0005388 name: respiratory system trait namespace: Trait.ontology subset: slim_cattle subset: slim_chkn subset: slim_pig synonym: "lung" EXACT [] synonym: "pulmonary" EXACT [] is_a: MT:0000001 ! Trait [Term] id: MT:0005389 name: reproductive system trait namespace: Trait.ontology subset: slim_cattle subset: slim_chkn subset: slim_pig synonym: "reproduction" EXACT [] is_a: MT:0000001 ! Trait [Term] id: MT:0005390 name: skeleton trait namespace: Trait.ontology subset: slim_cattle subset: slim_chkn subset: slim_pig synonym: "bone" EXACT [] is_a: MT:0000001 ! Trait [Term] id: MT:0005391 name: vision/eye trait namespace: Trait.ontology is_a: MT:0000001 ! Trait [Term] id: MT:0005392 name: touch/vibrissae trait namespace: Trait.ontology is_a: MT:0000001 ! Trait [Term] id: MT:0005393 name: skin/coat/nails/feathers trait namespace: Trait.ontology subset: slim_cattle subset: slim_chkn subset: slim_pig is_a: MT:0000001 ! Trait [Term] id: MT:0005394 name: taste/olfaction trait namespace: Trait.ontology is_a: MT:0000001 ! Trait [Term] id: MT:0005395 name: other trait namespace: Trait.ontology subset: slim_cattle subset: slim_pig is_a: MT:0000001 ! Trait [Term] id: MT:0005397 name: hematopoietic system trait namespace: Trait.ontology subset: slim_cattle subset: slim_chkn subset: slim_pig synonym: "hemopoietic system phenotype" EXACT [] is_a: MT:0000001 ! Trait [Term] id: MT:0005398 name: susceptibility to fungal infection namespace: Trait.ontology def: "reduced likelihood that an organism will develop ill effects from infection by a yeast or mold, or from components of, or toxins produced by, these organisms " [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "decreased susceptibility to mold infection" EXACT [] synonym: "decreased susceptibility to yeast infection" EXACT [] is_a: MT:0001793 ! susceptibility to infection [Term] id: MT:0005400 name: vitamin level namespace: Trait.ontology def: "anomalous concentration of any of the organic substances found in food that are necessary in trace amounts for normal metabolic function" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0004019 ! vitamin homeostasis [Term] id: MT:0005401 name: fat-soluble vitamin level namespace: Trait.ontology def: "anomalous concentration of any of the organic substances found in food that are necessary in trace amounts for normal metabolic function and which require the presence of lipids for assimilation in the body" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0005400 ! vitamin level [Term] id: MT:0005402 name: action potential namespace: Trait.ontology def: "change in the electric response of a nerve or other excitable tissue to its stimulation" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0002272 ! nervous system electrophysiology [Term] id: MT:0005403 name: nerve conduction namespace: Trait.ontology def: "anomaly in the act of transmitting electricity along a single nerve" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002272 ! nervous system electrophysiology [Term] id: MT:0005404 name: axon morphology namespace: Trait.ontology def: "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002882 ! neuron [Term] id: MT:0005405 name: axon integrity namespace: Trait.ontology def: "retrogressive pathologic change in the single process of a nerve cell " [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000958 ! peripheral nervous system integrity is_a: MT:0002229 ! neural integrity [Term] id: MT:0005406 name: heart size namespace: Trait.ontology def: "the physical dimensions, proportions, magnitude, or extent of the cardiac muscle or any of its component structures" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] subset: slim_chkn subset: slim_pig synonym: "cardiac size" RELATED [] relationship: part_of MT:0000266 ! cardiac morphology [Term] id: MT:0005409 name: coat color intensity namespace: Trait.ontology def: "amount and distribution of yellow pigment (phaeomelanin) relative to black or brown pigment (eumelanin) is decreased when compared to wild-type agouti" [llw2:Linda Washburn_Mouse Genome Informatics Curator] is_a: MT:0002075 ! coat color [Term] id: MT:0005410 name: fertilization namespace: Trait.ontology def: "anomaly in the process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronuclei" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] subset: slim_cattle subset: slim_chkn is_a: MT:0001919 ! reproductive system physiology [Term] id: MT:0005411 name: onset of fertilization namespace: Trait.ontology def: "a lag in the normal time of onset of the process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronuclei" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0005410 ! fertilization [Term] id: MT:0005412 name: blood vessel patency namespace: Trait.ontology def: "any measurable characteristic pertaining to the openness of the tubes that carry blood through the body" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] synonym: "vascular patency" RELATED [] relationship: part_of MT:0000088 ! blood vessel integrity [Term] id: MT:0005414 name: extrahepatic cholestasis namespace: Trait.ontology def: "impairment of bile flow in the large bile ducts by mechanical obstruction or stricture due to benign or malignant process" [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "extrahepatic bile duct obstruction" EXACT [] synonym: "extrahepatic bile stasis" EXACT [] synonym: "extrahepatic biliary stasis" EXACT [] is_a: MT:0000610 ! cholestasis [Term] id: MT:0005415 name: intrahepatic cholestasis namespace: Trait.ontology def: "impairment of bile flow due to injury to the hepatocytes, bile canaliculi, or the intrahepatic bile ducts" [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "intrahepatic bile duct obstruction" EXACT [] synonym: "intrahepatic bile stasis" EXACT [] synonym: "intrahepatic biliary stasis" EXACT [] is_a: MT:0000610 ! cholestasis [Term] id: MT:0005416 name: circulating protein level namespace: Trait.ontology def: "anomalous blood concentration of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] subset: slim_chkn subset: slim_pig synonym: "abnormal protein level" EXACT [] is_a: MT:0000179 ! blood chemistry [Term] id: MT:0005418 name: circulating hormone level namespace: Trait.ontology def: "anomalous blood concentration of any of the chemical substances that have specific regulatory effects on the activity of a certain organ or organs; originally applied to substances secreted by various endocrine glands and transported in the bloodstream to the target organs, it is sometimes extended to include substances that are not produced by the endocrine glands but that have similar effects" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] subset: slim_cattle subset: slim_chkn subset: slim_pig is_a: MT:0000179 ! blood chemistry is_a: MT:0003953 ! hormone level [Term] id: MT:0005421 name: loose skin namespace: Trait.ontology def: "condition in which the skin hangs in folds" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "cutis laxa" EXACT [] synonym: "dermatochalasis" EXACT [] is_a: MT:0001191 ! skin condition [Term] id: MT:0005422 name: osteosclerosis namespace: Trait.ontology def: "abnormal hardening or eburnation (change in exposed subchondral bone in degenerative joint disease in which bone is converted into a dense substance with a smooth surface) of bone " [cml:Cathleen M. Lutz_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "bone sclerosis" EXACT [] is_a: MT:0003795 ! bone structure [Term] id: MT:0005423 name: somatic nervous system physiology namespace: Trait.ontology def: "anomalous function of any of the cranial and spinal nerves or their ganglia or the peripheral sensory receptors" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0003633 ! nervous system physiology [Term] id: MT:0005424 name: body movement namespace: Trait.ontology is_a: MT:0001516 ! motor coordination/ balance [Term] id: MT:0005428 name: clinical chemistry namespace: Trait.ontology def: "any anomaly in the laboratory tests that show the presence of physiologically significant substances in the blood, urine, tissue, and body fluids with application to the diagnosis or therapy of disease" [MeSH:National Library of Medicine_Medical Subject Headings] subset: slim_cattle subset: slim_chkn subset: slim_pig is_a: MT:0001764 ! homeostasis [Term] id: MT:0005429 name: pine bedding color after urinary excretion namespace: Trait.ontology def: "with normal urine coloration, a change in the hue of the pine bedding of a mouse, often to a bright yellow or chartreuse, after excretion of urine by the animal housed with this type of bedding; indicative of a metabolic defect" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, llw2:Linda Washburn_Mouse Genome Informatics Curator] is_a: MT:0001757 ! urine chemistry [Term] id: MT:0005431 name: oocyte number namespace: Trait.ontology def: "reduced numbers or absence of germ cells in the female" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, llw2:Linda Washburn_Mouse Genome Informatics Curator] synonym: "female germ cell depletion" EXACT [] is_a: MT:0002209 ! germ cell number [Term] id: MT:0005432 name: pro-B cell morphology/development namespace: Trait.ontology def: "anomalous structure, development, or number of cells in the developing B cell lineage that have displayed B cell surface markers, but have not yet completed heavy chain gene rearrangement" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] synonym: "pro-B cell abnormalities" EXACT [] is_a: MT:0002144 ! B lymphocyte development [Term] id: MT:0005437 name: glycogen level namespace: Trait.ontology def: "anomalous concentration of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] subset: slim_pig relationship: part_of ID:0000694 ! muscle glycogen homeostasis relationship: part_of MT:0005438 ! glycogen homeostasis [Term] id: MT:0005438 name: glycogen homeostasis namespace: Trait.ontology def: "abnormal processing and or utilization of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] subset: slim_pig is_a: MT:0002078 ! glucose homeostasis [Term] id: MT:0005442 name: pyramidal neuron morphology namespace: Trait.ontology def: "anomaly of the malformed projection neurons in the cerebral cortex and hippocampus" [MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal pyramidal cell" EXACT [] is_a: MT:0000788 ! cerebral cortex morphology is_a: MT:0000807 ! hippocampus morphology is_a: MT:0002882 ! neuron [Term] id: MT:0005443 name: ethanol metabolism namespace: Trait.ontology def: "altered ability to metabolize the clear, colorless liquid that is the primary ingredient in alcoholic beverages" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, J:55555, MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal alcohol metabolism" EXACT [] is_a: MT:0002585 ! response/metabolism to xenobiotics [Term] id: MT:0005444 name: retinol metabolism namespace: Trait.ontology def: "altered ability to metabolize this organic compound that plays an essential role in metabolic functioning of the retina, the growth of and differentiation of epithelial tissue, the growth of bone, reproduction, and the immune response " [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, J:55555, MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0004019 ! vitamin homeostasis [Term] id: MT:0005445 name: neurotransmitter release namespace: Trait.ontology def: "aberration in the secretion of endogenous signaling molecules normally secreted by neurons that alter the behavior of neurons or effector cells" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0002204 ! neurotransmitter level [Term] id: MT:0005446 name: synaptic epinephrine release namespace: Trait.ontology def: "aberrant secretion across synapses of the active sympathomimetic hormone that stimulates both the alpha- and beta- adrenergic systems, causes systemic vasoconstriction and gastrointestinal relaxation, stimulates the heart, and dilates bronchi and cerebral vessels" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal synaptic adrenaline release" EXACT [] is_a: MT:0005445 ! neurotransmitter release [Term] id: MT:0005447 name: synaptic norepinephrine release namespace: Trait.ontology def: "aberrant secretion across synapses of this widespread central and autonomic neurotransmitter, the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal synaptic norepinephrine release" EXACT [] is_a: MT:0005445 ! neurotransmitter release [Term] id: MT:0005448 name: energy balance namespace: Trait.ontology def: "aberrant intake or expenditure of calories as compared to the normal state" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] is_a: MT:0002121 ! metabolism [Term] id: MT:0005449 name: food intake namespace: Trait.ontology subset: slim_cattle subset: slim_pig synonym: "feed consumption" EXACT [] synonym: "food consumption" EXACT [] is_a: MT:0001431 ! eating behavior [Term] id: MT:0005450 name: energy expenditure namespace: Trait.ontology def: "utilization of calories that differs from normal " [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "abnormal energy metabolism" EXACT [] is_a: MT:0005448 ! energy balance [Term] id: MT:0005451 name: body composition namespace: Trait.ontology def: "anomalous relative amounts of various components of the body, such as percent body fat" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] subset: slim_pig is_a: MT:0001764 ! homeostasis [Term] id: MT:0005452 name: body fat amount namespace: Trait.ontology subset: slim_cattle subset: slim_chkn subset: slim_pig is_a: MT:0000003 ! adipose tissue morphology [Term] id: MT:0005456 name: weight gain namespace: Trait.ontology def: "number of excess calories needed to increase body weight by a specified amount" [MeSH:National Library of Medicine_Medical Subject Headings] subset: slim_cattle subset: slim_pig is_a: MT:0001259 ! body weight [Term] id: MT:0005457 name: percent body fat namespace: Trait.ontology is_a: MT:0005452 ! body fat amount [Term] id: MT:0005460 name: leukopoiesis namespace: Trait.ontology alt_id: MT:0002430 def: "anomalous process of generating white blood cells (leukocytes) from the pluripotent hematopoietic stem cells of the bone marrow; two significant pathways generate various types of leukocytes: myelopoiesis, in which leukocytes in the blood are derived from myeloid stem cells, and lymphopoiesis, in which leukocytes of the lymphatic system (lymphocytes) are generated from lymphoid stem cells" [MeSH:National Library of Medicine_Medical Subject Headings] subset: slim_pig synonym: "abnormal leukocyte morphology/development" EXACT [] synonym: "leukocyte abnormalities" EXACT [] synonym: "white blood cell abnormalities" EXACT [] is_a: MT:0002123 ! hematopoiesis is_a: MT:0002449 ! immune cell development [Term] id: MT:0005461 name: dendritic cell morphology/development namespace: Trait.ontology def: "anomalous structure or atypical formation of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0005460 ! leukopoiesis [Term] id: MT:0005462 name: mast cell morphology/development namespace: Trait.ontology def: "anomalous structure, development or number of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0002422 ! basophil morphology/development [Term] id: MT:0005463 name: CD4+ T cell physiology namespace: Trait.ontology def: "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] subset: slim_pig synonym: "abnormal CD4+ T cell function" EXACT [] synonym: "CD4+ T cell dysfunction" EXACT [] is_a: MT:0002444 ! T cell physiology [Term] id: MT:0005464 name: platelet physiology namespace: Trait.ontology def: "atypical response of the non-nucleated cells found in the blood and involved in blood coagulation" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal platelet function" EXACT [] is_a: MT:0001545 ! hematopoietic system physiology is_a: MT:0002551 ! blood coagulation [Term] id: MT:0005465 name: T helper 1 physiology namespace: Trait.ontology def: "anomalous response of the subset of helper T cells that enhance cell-mediated immune responses; these cells secrete IL-1 and gamma-IFN and are generally involved in inflammatory responses" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Immunobiology_The Immune System in Health and Disease:ISBN 0-8153-1691-7] synonym: "abnormal T helper 1 function" EXACT [] synonym: "abnormal TH1 function" EXACT [] synonym: "abnormal Th1 function" EXACT [] is_a: MT:0005463 ! CD4+ T cell physiology [Term] id: MT:0005466 name: T helper 2 physiology namespace: Trait.ontology def: "anomalous response of the subset of T helper cells that enhance humoral immunity and inhibit cell-mediated immune responses; these cells produce IL-4 and induce B cells to produce IgE and IgG1, while also supporting eosinophil and mast cell functions" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "abnormal T helper 2 function" EXACT [] synonym: "abnormal TH2 function" EXACT [] synonym: "abnormal Th2 function" EXACT [] is_a: MT:0005463 ! CD4+ T cell physiology [Term] id: MT:0005467 name: chemotactic leukotriene physiology namespace: Trait.ontology def: "functional anomaly of any of a subset of leukotrienes that are involved in attracting leukocytes to a site of tissue injury" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] is_a: MT:0002522 ! chemotactic factor physiology [Term] id: MT:0005468 name: thyroid hormone level namespace: Trait.ontology def: "aberrant concentration of any of the hormones secreted by the thyroid gland" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, J:13923, MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0003953 ! hormone level [Term] id: MT:0005469 name: thyroxine level namespace: Trait.ontology def: "anomalous concentration of the major hormone derived from the thyroid gland; it normally affects cellular metabolism" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, J:13923, MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal T4 level" EXACT [] synonym: "abnormal thyroxin level" EXACT [] is_a: MT:0005468 ! thyroid hormone level [Term] id: MT:0005472 name: triiodothyronine level namespace: Trait.ontology def: "aberrant concentration of this hormone synthesized and secreted by the thyroid; normally, this is the main thyroid hormone used by the tissues" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal T3 level" EXACT [] is_a: MT:0005468 ! thyroid hormone level [Term] id: MT:0005475 name: circulating thryoxine level namespace: Trait.ontology def: "anomalous blood concentration of the major hormone derived from the thyroid gland; it normally affects cellular metabolism" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal circulating level of T4" EXACT [] synonym: "abnormal circulating level of thryoxin" EXACT [] synonym: "abnormal circulating level of thryoxine" EXACT [] is_a: MT:0005469 ! thyroxine level [Term] id: MT:0005476 name: circulating triiodothyronine level namespace: Trait.ontology def: "aberration in the blood concentration of this hormone synthesized and secreted by the thyroid; normally, this is the main thyroid hormone used by the tissues" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal circulating level of T3" EXACT [] synonym: "abnormal circulating level of triiodothyronine" EXACT [] is_a: MT:0003351 ! circulating levels of thyroid hormone is_a: MT:0005472 ! triiodothyronine level [Term] id: MT:0005478 name: circulating thyroxine level namespace: Trait.ontology def: "less than the normal blood concentration of the major hormone derived from the thyroid gland; it normally affects cellular metabolism" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] synonym: "decreased circulating level of T4" EXACT [] synonym: "decreased circulating level of thyroxin" EXACT [] synonym: "decreased circulating level of thyroxine" EXACT [] is_a: MT:0003351 ! circulating levels of thyroid hormone [Term] id: MT:0005481 name: chronic myelocytic leukemia namespace: Trait.ontology def: "a heterogeneous group of myeloproliferative disorders that may evolve into acute leukemia in late stages " [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "chronic granulocytic leukemia" EXACT [] synonym: "chronic myelogenous leukemia" EXACT [] synonym: "chronic myeloid leukemia" EXACT [] synonym: "CML" EXACT [] is_a: MT:0002026 ! leukemia [Term] id: MT:0005488 name: bronchial epithelial cell number namespace: Trait.ontology def: "increased numbers of cells lining the inner surfaces of the bronchi" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0002264 ! bronchus morphology [Term] id: MT:0005490 name: Clara cell number namespace: Trait.ontology def: "increased numbers of the rounded, club-shaped, nonciliated cells found between ciliated cells in bronchiolar epithelium" [J:48446, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002264 ! bronchus morphology [Term] id: MT:0005493 name: stomach epithelial cell number namespace: Trait.ontology synonym: "gastric epithelial hyperplasia" EXACT [] is_a: MT:0000471 ! stomach epithelium morphology [Term] id: MT:0005494 name: esophagogastric junction metaplasia namespace: Trait.ontology def: "conversion of one differentiated cell type to another differentiated cell type at the terminal end of the esophagus and beginning of the stomach" [J:48446, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "G-E junction metaplasia" EXACT [] is_a: MT:0000467 ! esophagus morphology is_a: MT:0005213 ! gastric metaplasia [Term] id: MT:0005495 name: macrophage recruitment namespace: Trait.ontology def: "fewer than normal macrophages accumulate in a specific location in response to a wide variety of substances released at the sites of inflammatory reactions" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0002451 ! macrophage physiology [Term] id: MT:0005497 name: optic nerve cupping namespace: Trait.ontology def: "concave shape of the nerve often as a result of the force of pressure from glaucoma" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "cupping of optic nerve" EXACT [] is_a: MT:0001330 ! optic nerve morphology [Term] id: MT:0005499 name: olfactory system morphology namespace: Trait.ontology def: "anomalous structure of the organs involved in smell" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] is_a: MT:0005394 ! taste/olfaction trait [Term] id: MT:0005500 name: gustatory system morphology namespace: Trait.ontology def: "structural anomaly of the organs involved in taste" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0005394 ! taste/olfaction trait [Term] id: MT:0005501 name: skin physiology namespace: Trait.ontology def: "atypical function of the membranous protective covering of the body" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0005393 ! skin/coat/nails/feathers trait [Term] id: MT:0005502 name: urinary system physiology namespace: Trait.ontology def: "functional anomaly of any of the organs involved in the production or excretion of urine" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] synonym: "abnormal urinary system function" EXACT [] is_a: MT:0005367 ! renal/urinary system trait [Term] id: MT:0005503 name: tendon morphology namespace: Trait.ontology def: "structural anomaly of the fibrous bands or cords of connective tissue at the ends of muscle fibers that attach muscles to bones and other structures" [J:45509, MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0002108 ! muscle morphology is_a: MT:0005508 ! skeleton morphology [Term] id: MT:0005504 name: ligament morphology namespace: Trait.ontology def: "structural anomaly of the flexible bands of fibrous tissue that connect the articular extremities of bones" [J:45509, MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0005508 ! skeleton morphology [Term] id: MT:0005508 name: skeleton morphology namespace: Trait.ontology alt_id: MT:0000055 def: "malformation of the bony framework of the body in vertebrates" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] subset: slim_cattle subset: slim_chkn subset: slim_pig synonym: "abnormal bone/ skeleton" EXACT [] synonym: "bone/ skeletal abnormalities" EXACT [] is_a: MT:0005390 ! skeleton trait [Term] id: MT:0005509 name: tongue neoplasm namespace: Trait.ontology def: "new abnormal growth of the tongue" [MeSH:National Library of Medicine_Medical Subject Headings, RGD:Rat Genome Database submission] is_a: MT:0002019 ! tumor incidence [Term] id: MT:0005511 name: susceptibility to tongue neoplasm namespace: Trait.ontology def: "reduced likelihood of developing an abnormal growth of tongue tissue" [MeSH:National Library of Medicine_Medical Subject Headings, RGD:Rat Genome Database submission] synonym: "resistance to tongue tumor" EXACT [] is_a: MT:0005514 ! susceptibility to tumor development [Term] id: MT:0005512 name: susceptibility to mammary neoplasm namespace: Trait.ontology def: "reduced likelihood of developing an abnormal growth of mammary tissue" [MeSH:National Library of Medicine_Medical Subject Headings, RGD:Rat Genome Database submission] synonym: "resistance to mammary tumor" EXACT [] is_a: MT:0005514 ! susceptibility to tumor development [Term] id: MT:0005513 name: susceptibility to liver neoplasm namespace: Trait.ontology def: "likelihood of developing an abnormal growth of liver tissue" [MeSH:National Library of Medicine_Medical Subject Headings, RGD:Rat Genome Database submission] synonym: "resistance to liver tumor" EXACT [] is_a: MT:0005514 ! susceptibility to tumor development [Term] id: MT:0005514 name: susceptibility to tumor development namespace: Trait.ontology def: "reduced likelihood of developing new abnormal growth of any tissue" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator, cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, RGD:Rat Genome Database submission] synonym: "resistance to neoplasm development" EXACT [] is_a: MT:0002019 ! tumor incidence [Term] id: MT:0005515 name: uveitis namespace: Trait.ontology def: "inflammation of part or all of the uvea, the middle (vascular) tunic of the eye, and commonly involving the other tunics (sclera and cornea, and the retina)" [MeSH:National Library of Medicine_Medical Subject Headings, RGD:Rat Genome Database submission] is_a: MT:0001851 ! eye inflammation is_a: MT:0005197 ! uvea morphology [Term] id: MT:0005518 name: pancreas regeneration namespace: Trait.ontology def: "deviation from the normal ability of the pancreas to regenerate healthy tissue following injury" [RGD:Rat Genome Database submission] is_a: MT:0002693 ! pancreas physiology [Term] id: MT:0005521 name: circulating atrial natriuretic factor level namespace: Trait.ontology def: "deviation from the normal concentration of this peptide hormone in the blood; it regulates the water-electrolyte balance and acts as a vasodilator" [MeSH:National Library of Medicine_Medical Subject Headings, RGD:Rat Genome Database submission] is_a: MT:0005418 ! circulating hormone level [Term] id: MT:0005524 name: renal plasma flow rate namespace: Trait.ontology def: "volume of plasma passing through the kidney per unit time" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] is_a: MT:0000233 ! blood flow velocity is_a: MT:0002136 ! kidney physiology [Term] id: MT:0005529 name: renal vascular resistance namespace: Trait.ontology def: "force opposing blood flow in the kidney blood vessels" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] is_a: MT:0002136 ! kidney physiology is_a: MT:0005532 ! vascular resistance [Term] id: MT:0005532 name: vascular resistance namespace: Trait.ontology def: "force opposing the flow of blood through a vascular bed; it is equal to the difference in blood pressure across the vascular bed divided by the cardiac output" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] is_a: MT:0002128 ! blood circulation [Term] id: MT:0005535 name: body temperature namespace: Trait.ontology def: "deviation in the level of heat natural to a living being" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, RGD:Rat Genome Database submission, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] subset: slim_pig is_a: MT:0001764 ! homeostasis [Term] id: MT:0005537 name: cerebral aqueduct morphology namespace: Trait.ontology def: "anomalous structure of the channel in the mesencephalon that connects the third and fourth ventricles" [hdene:Howard Dene_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] synonym: "abnormal aqueduct of Sylvius" EXACT [] is_a: MT:0000897 ! midbrain morphology [Term] id: MT:0005540 name: albumin excretion namespace: Trait.ontology def: "less than the normal amount of this protein voided by the kidneys" [RGD:Rat Genome Database submission] is_a: MT:0005555 ! kidney excretion [Term] id: MT:0005541 name: iris stromal pigmentation namespace: Trait.ontology def: "anomalous coloring of the framework of the iris" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] is_a: MT:0005102 ! iris pigmentation is_a: MT:0005208 ! iris stroma morphology [Term] id: MT:0005542 name: corneal vascularization namespace: Trait.ontology def: "formation of blood vessels in the cornea, which normally lacks vessels" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001312 ! cornea morphology [Term] id: MT:0005543 name: corneal thickness namespace: Trait.ontology def: "decreased thickness of the cornea, the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "thin cornea" EXACT [] is_a: MT:0001312 ! cornea morphology [Term] id: MT:0005544 name: corneal deposits namespace: Trait.ontology def: "accumulation of minerals, proteins, or other anomalous substances on the cornea" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] is_a: MT:0001312 ! cornea morphology [Term] id: MT:0005545 name: lens development namespace: Trait.ontology def: "aberrant formation of the transparent structure of the eye responsible for focusing light rays" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] is_a: MT:0001286 ! eye development is_a: MT:0001303 ! lens morphology [Term] id: MT:0005546 name: choroidal vascularization namespace: Trait.ontology def: "new vessel development of the thin, highly vascularized membrane covering most of the posterior of the eye between the retina and the sclera" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] is_a: MT:0003710 ! vascularization [Term] id: MT:0005547 name: Muller cell morphology namespace: Trait.ontology def: "anomalous structure of the elongated neuroglial cells that traverse all the layers of the retina and that act as supporting elements" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal Muller fiber morphology" EXACT [] is_a: MT:0001325 ! retina morphology [Term] id: MT:0005548 name: retinal pigment epithelium size namespace: Trait.ontology def: "wasting or decreased size of the epithelial layer of the retina composed of cells containing pigment granules " [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "atrophy of retinal pigment epithelium" EXACT [] is_a: MT:0005201 ! retinal pigment epithelium morphology [Term] id: MT:0005549 name: retinal pigment epithelium cell number namespace: Trait.ontology def: "increased numbers of cells in the epithelial layer of the retina composed of cells containing pigment granules " [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] synonym: "hyperplasia of retinal pigment epithelium" EXACT [] is_a: MT:0005548 ! retinal pigment epithelium size [Term] id: MT:0005550 name: orbital hemorrhage namespace: Trait.ontology def: "escape of blood into the orbit " [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] is_a: MT:0005246 ! orbit morphology [Term] id: MT:0005551 name: eye electrophysiology namespace: Trait.ontology def: "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel_Neuroscience Mutagenesis Facility Curator] is_a: MT:0005253 ! eye physiology [Term] id: MT:0005552 name: orbital bone morphology namespace: Trait.ontology def: "structural anomaly of the bony cavity that contains the eyeball and is formed by parts of eight bones in the mouse: maxilla, lacrimal, zygomatic, frontal, temporal, sphenoid, ethmoid, palatine " [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal orbital bones" EXACT [] is_a: MT:0000438 ! skull morphology [Term] id: MT:0005555 name: kidney excretion namespace: Trait.ontology def: "altered ability of the kidneys to void specific substances" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] is_a: MT:0003606 ! kidney function [Term] id: MT:0005556 name: kidney clearance namespace: Trait.ontology def: "altered ability of the kidneys to remove substances from the plasma for excretion in a specific period of time" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] is_a: MT:0003606 ! kidney function [Term] id: MT:0005558 name: creatinine clearance namespace: Trait.ontology def: "less than the normal amount of this creatine metabolite filtered by the kidneys in a specific period of time; indicative of kidney function" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, RGD:Rat Genome Database submission] is_a: MT:0005556 ! kidney clearance [Term] id: MT:0005563 name: hemoglobin content namespace: Trait.ontology def: "deviation from the normal total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith_Mouse Genome Informatics Curator] is_a: MT:0001588 ! hemoglobin [Term] id: MT:0005567 name: circulating total protein level namespace: Trait.ontology def: "less than the average total concentration of these macromolecules in the blood " [RGD:Rat Genome Database submission] synonym: "decreased plasma total protein level" EXACT [] synonym: "decreased total protein level" EXACT [] is_a: MT:0005416 ! circulating protein level [Term] id: MT:0005570 name: sodium excretion namespace: Trait.ontology def: "less than the normal amount of this element voided by the kidneys in a specific period of time" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, RGD:Rat Genome Database submission] is_a: MT:0005555 ! kidney excretion [Term] id: MT:0005572 name: breathing frequency namespace: Trait.ontology def: "deviation from the normal number of breaths in a given period of time" [RGD:Rat Genome Database submission] is_a: MT:0001951 ! breathing [Term] id: MT:0005577 name: uterine prolapse namespace: Trait.ontology def: "downward movement, and possible external appearance, of the uterus through the vagina" [J:88284, MeSH:National Library of Medicine_Medical Subject Headings, pvb:Pierre Vanden Borre_Mouse Genome Informatics Curator] is_a: MT:0001120 ! uterus morphology [Term] id: MT:0005578 name: teratozoospermia namespace: Trait.ontology def: "presence of malformed spermatozoa in the semen; malformations include the physical bending of the sperm to produce kinks or bends" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "teratospermia" EXACT [] is_a: MT:0001156 ! spermatogenesis is_a: MT:0002208 ! germ cell morphology [Term] id: MT:0005580 name: periinsulitis namespace: Trait.ontology def: "early pancreatic infiltration of mononuclear cells around pancreatic Langerhans islets" [il:Ira Lu_Mouse Genome Informatics Curator, J:11442] synonym: "peri-insulitis" EXACT [] synonym: "periinsulinitis" EXACT [] is_a: MT:0001869 ! pancreas inflammation [Term] id: MT:0005581 name: renin activity namespace: Trait.ontology def: "altered ability of this enzyme to cleave angiotensinogen and create angiotensin I" [MeSH:National Library of Medicine_Medical Subject Headings, RGD:Rat Genome Database submission] synonym: "abnormal angiotensinogenase activity" EXACT [] is_a: MT:0005584 ! enzyme/coenzyme activity [Term] id: MT:0005584 name: enzyme/coenzyme activity namespace: Trait.ontology def: "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002121 ! metabolism [Term] id: MT:0005587 name: Meckel's cartilage morphology namespace: Trait.ontology def: "formation or structure of this cartilage bar in the mandibular arch that forms a temporary supporting structure in the embryonic mandible; gives rise to middle ear bones and sphenomandibular and anterior malleolar ligaments" [J:17694, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "mandibular cartilage morphology" EXACT [] synonym: "Meckel cartilage morphology" EXACT [] is_a: MT:0000163 ! cartilage morphology is_a: MT:0003935 ! craniofacial development is_a: MT:0003938 ! ear development [Term] id: MT:0005592 name: blood vessel smooth muscle morphology namespace: Trait.ontology def: "any measurable or observable characteristic related to the shape, structure, color or pattern of the nonstriated, involuntary muscle tissue of the blood vessels" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] synonym: "vascular smooth muscle morphology" RELATED [] xref: MP:0005592 is_a: MT:0000767 ! smooth muscle morphology relationship: part_of MT:0001614 ! blood vessel morphology [Term] id: MT:0005593 name: vascular smooth muscle contraction namespace: Trait.ontology def: "altered or unexpected constriction of the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine_Medical Subject Headings, RGD:Rat Genome Database submission] is_a: MT:0000740 ! smooth muscle contractility is_a: MT:0005595 ! vascular smooth muscle physiology [Term] id: MT:0005594 name: vascular smooth muscle dilation namespace: Trait.ontology def: "altered or unexpected widening of the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine_Medical Subject Headings, RGD:Rat Genome Database submission] is_a: MT:0005595 ! vascular smooth muscle physiology [Term] id: MT:0005595 name: vascular smooth muscle physiology namespace: Trait.ontology def: "anomalous function of the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine_Medical Subject Headings, RGD:Rat Genome Database submission] is_a: MT:0002106 ! muscle physiology [Term] id: MT:0005597 name: susceptibility to type I hypersensitivity reaction namespace: Trait.ontology def: "less likelihood or resistance to developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, J:68588, Pathology:ISBN 0-397-51047-0] comment: examples: hay fever, asthma, anaphylaxis synonym: "decreased susceptibility to anaphylaxis" EXACT [] synonym: "decreased susceptibility to immediate type hypersensitivity" EXACT [] is_a: MT:0002531 ! type I hypersensitivity reaction [Term] id: MT:0005598 name: ventricle muscle contractility namespace: Trait.ontology def: "ability of the heart ventricle muscle to shorten or to develop increased tension" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] synonym: "ventricular muscle contractility" EXACT [] is_a: MT:0002972 ! cardiac muscle contractility [Term] id: MT:0005603 name: neuron size namespace: Trait.ontology def: "increased mass of any of the structural and functional units of the nervous system, which consist of the nerve cell body, the dendrites, and the axon" [RGD:Rat Genome Database submission, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "neuronal hypertrophy" EXACT [] is_a: MT:0002882 ! neuron [Term] id: MT:0005607 name: bleeding time namespace: Trait.ontology def: "less than the normal duration of blood flow after skin puncture; indicative of platelet and capillary function" [MeSH:National Library of Medicine_Medical Subject Headings, RGD:Rat Genome Database submission] is_a: MT:0002551 ! blood coagulation [Term] id: MT:0005608 name: heart interstices patency namespace: Trait.ontology def: "openness of the small spaces within the tissue of the heart" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] synonym: "cardiac interstices patency" RELATED [] relationship: part_of MT:0000053 ! heart integrity [Term] id: MT:0005609 name: circulating antidiuretic hormone level namespace: Trait.ontology def: "deviation from the normal concentration of this peptide hormone in the blood; it is normally released by the neurohypophysis to control water metabolism and balance by regulating water loss; it also contracts smooth muscle" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings, RGD:Rat Genome Database submission] synonym: "abnormal circulating level of ADH" EXACT [] synonym: "abnormal circulating level of antidiuretic hormone" EXACT [] synonym: "abnormal circulating level of vasopressin" EXACT [] is_a: MT:0005418 ! circulating hormone level [Term] id: MT:0005612 name: susceptibility to type II hypersensitivity reaction namespace: Trait.ontology def: "less likelihood of or resistance to developing a response caused by an Ag-Ab reaction; antibodies are directly or indirectly cytotoxic to antigens on cell surfaces or in connective tissues; most often involves IgG and IgM; complement activation is usually involved" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Pathology:ISBN 0-397-51047-0] comment: examples: autoimmune diseases: autoimmune hemolytic anemias, antibody-dependent cellular cytotoxicity (ADCC), Goodpasture disease, myasthenia gravis, Graves disease, pemphigous, pemphigoid synonym: "decreased susceptibility to antibody-mediated cellular toxicity" EXACT [] synonym: "decreased susceptibility to cytotoxic type hypersensitivity" EXACT [] is_a: MT:0002532 ! type II hypersensitivity reaction [Term] id: MT:0005614 name: susceptibility to type III hypersensitivity reaction namespace: Trait.ontology def: "less likelihood of or resistance to developing tissue injury mediated by immune complexes; generally involves immune complexes formed in the blood via Abs encountering circulating Ag; Ag-Ab complexes then deposit in tissues (especially blood vessels and glomeruli), induce complement activation, and result in tissue injury" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Pathology:ISBN 0-397-51047-0] comment: Examples: Autoimmune diseases: systemic lupus erythmatosus (SLE), rheumatoid arthritis, sjogren syndrome, scleroderma. glomerulonephritis synonym: "decreased susceptibility to immune complex mediated hypersensitivity" EXACT [] is_a: MT:0002533 ! type III hypersensitivity reaction [Term] id: MT:0005616 name: susceptibility to type IV hypersensitivity reaction namespace: Trait.ontology def: "less likelihood of or resistance to developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Pathology:ISBN 0-397-51047-0] comment: Examples: granulomatous diseases: tuberculosis, sarcoidosis. contact dermatitis: elicited by poison ivy, detergents, clothing, etc. synonym: "decreased susceptibility to cell-mediated hypersensitivity" EXACT [] synonym: "decreased susceptibility to delayed type hypersensitivity" EXACT [] is_a: MT:0002534 ! type IV hypersensitivity reaction [Term] id: MT:0005618 name: potassium excretion namespace: Trait.ontology def: "less than the normal amount of this alkaline metallic element, the most abundant intracellular ion, voided by the kidneys" [MeSH:National Library of Medicine_Medical Subject Headings, RGD:Rat Genome Database submission] is_a: MT:0005555 ! kidney excretion [Term] id: MT:0005620 name: muscle contractility namespace: Trait.ontology def: "aberrant ability of a muscle to shorten or to develop increased tension" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] subset: slim_chkn is_a: MT:0002106 ! muscle physiology [Term] id: MT:0005621 name: cell physiology namespace: Trait.ontology def: "aberration in the vital processes of the cell " [hdene:Howard Dene_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0005384 ! cellular trait [Term] id: MT:0005623 name: meninges morphology namespace: Trait.ontology def: "anomaly in any of the membranes covering the spinal cord and brain, including the dura mater (external), arachnoid (middle), and pia mater (internal)" [J:48079, smb:Susan M. Bello_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0000955 ! spinal cord morphology is_a: MT:0002152 ! brain morphology [Term] id: MT:0005624 name: plasma anion gap namespace: Trait.ontology def: "measurement of the interval between the sum of routinely measured cations minus the sum of the routinely measured anions in the blood; the anion gap = (Na+ + K+) - (Cl- + HCO3-) where Na- is sodium, K+ is potassium, Cl- is chloride, and HCO3- is bicarbonate " [RGD:Rat Genome Database submission] is_a: MT:0001765 ! ion homeostasis [Term] id: MT:0005629 name: lung weight namespace: Trait.ontology def: "any change from the normal state in the physical heaviness of the lung" [RGD:Rat Genome Database submission] subset: slim_chkn is_a: MT:0003641 ! lung size [Term] id: MT:0005636 name: mineral homeostasis namespace: Trait.ontology def: "anomaly in the state of equilibrium in the body with respect to any of the inorganic substance that have importance in body functions" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001764 ! homeostasis [Term] id: MT:0005637 name: iron homeostasis namespace: Trait.ontology def: "anomaly in the state of equilibrium in the body with respect to this metallic element that normally occurs in the heme of hemoglobin, myoglobin, transferrin, ferritin, and iron-containing porphyrins; it is an essential component of enzymes such as catalase, peroxidase, and various cytochromes" [J:64456, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0005636 ! mineral homeostasis [Term] id: MT:0005638 name: hemochromatosis namespace: Trait.ontology def: "disorder due to the deposition of hemosiderin in the parenchymal cells, causing tissue damage and dysfunction of the liver, pancreas, heart, and pituitary" [J:64456, MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0001770 ! iron level [Term] id: MT:0005639 name: hemosiderosis namespace: Trait.ontology def: "condition in which there is a generalized increase in the iron stores of body tissues, particularly of liver and the reticuloendothelial system, without demonstrable tissue damage" [MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0001770 ! iron level [Term] id: MT:0005640 name: mean corpuscular hemoglobin concentration namespace: Trait.ontology def: "deviation from the normal Hgb/Hct; the average hemoglobin concentration in a given volume of packed red cells, calculated from the hemoglobin therein and the hematocrit, in erythrocyte indices" [J:8936, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] synonym: "abnormal MCHC" EXACT [] is_a: MT:0001588 ! hemoglobin [Term] id: MT:0005644 name: agonadal namespace: Trait.ontology def: "denoting the absence of gonads" [llw2:Linda Washburn_Mouse Genome Informatics Curator] is_a: MT:0002211 ! primary sex determination [Term] id: MT:0005645 name: hypothalamus physiology namespace: Trait.ontology def: "anomalous function of the ventral and medial region of the diencephalon forming the walls of the ventral half of the third ventricle, which is normally involved in the functions of the autonomic (visceral motor) nervous system and, through its vascular link with the anterior lobe of the pituitary gland, in endocrine mechanisms" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002164 ! gland physiology is_a: MT:0003633 ! nervous system physiology [Term] id: MT:0005646 name: pituitary gland physiology namespace: Trait.ontology def: "anomalous function of this unpaired compound gland suspended from the base of the hypothalamus by a short extension of the infundibulum, the infundibular or pituitary stalk" [Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0002164 ! gland physiology [Term] id: MT:0005647 name: sex gland physiology namespace: Trait.ontology def: "anomalous function of any of the organized aggregations of cells that function as secretory or excretory organs and are associated with reproduction" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] is_a: MT:0001919 ! reproductive system physiology is_a: MT:0002164 ! gland physiology [Term] id: MT:0005649 name: spleen neoplasm namespace: Trait.ontology def: "abnormal new cellular growth of the spleen" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, J:70407] synonym: "neoplastic spleen" EXACT [] synonym: "spleen neoplasia" EXACT [] is_a: MT:0002019 ! tumor incidence is_a: MT:0002225 ! spleen cellularity [Term] id: MT:0005650 name: limb bud morphology namespace: Trait.ontology def: "aberrant structure or development of any of the swellings on the trunk of the embryo that become limbs" [hdene:Howard Dene_Mouse Genome Informatics Curator, J:61460, MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0006279 ! limb development [Term] id: MT:0005651 name: gonad rudiment morphology namespace: Trait.ontology def: "absence or structural anomaly of the undifferentiated mesoderm that gives rise to the gonads" [llw2:Linda Washburn_Mouse Genome Informatics Curator] is_a: MT:0002210 ! sex determination [Term] id: MT:0005652 name: sex reversal namespace: Trait.ontology def: "development of the reproductive system is inconsistent with the chromosomal sex" [llw2:Linda Washburn_Mouse Genome Informatics Curator] is_a: MT:0002210 ! sex determination [Term] id: MT:0005653 name: phototoxicity namespace: Trait.ontology def: "condition caused by overexposure to UV light or from the combination of exposure to specific wavelengths and a phototoxic substance" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, J:80519, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0001191 ! skin condition is_a: MT:0002121 ! metabolism is_a: MT:0005501 ! skin physiology [Term] id: MT:0005654 name: porphyria namespace: Trait.ontology def: "acquired or inherited group of disorders characterized by excessive production of porphyrins or their precursors; if acquired, it results from inhibition of enzymes in the heme metabolic pathway by drugs, toxins or abnormal metabolites" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0004147 ! porphyrin level [Term] id: MT:0005657 name: neural plate morphology namespace: Trait.ontology def: "malformation or absence of the flat, thickened layer of ectodermal cells in the neuroectodermal area of the embryo's dorsal surface that develops into the neural tube and neural crest" [hdene:Howard Dene_Mouse Genome Informatics Curator, J:68142, Stedman's Medical Dictionary_27th edition:ISBN 0-683-40008-8] is_a: MT:0003861 ! nervous system development [Term] id: MT:0005658 name: susceptibility to diet-induced obesity namespace: Trait.ontology def: "probability of become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator] is_a: MT:0005450 ! energy expenditure [Term] id: MT:0005660 name: circulating adrenaline level namespace: Trait.ontology def: "aberrant concentration in the blood of this catecholamine hormone that stimulates the adrenergic receptors and that causes systemic vasoconstriction and gastrointestinal relaxation, stimulates the heart, and dilates bronchi and cerebral vessels" [MeSH:National Library of Medicine_Medical Subject Headings, pvb:Pierre Vanden Borre_Mouse Genome Informatics Curator] is_a: MT:0003962 ! adrenaline level is_a: MT:0005418 ! circulating hormone level [Term] id: MT:0005663 name: circulating noradrenaline level namespace: Trait.ontology def: "aberrant blood concentration of this precursor of epinephrine that is a widespread central and autonomic neurotransmitter" [MeSH:National Library of Medicine_Medical Subject Headings, pvb:Pierre Vanden Borre_Mouse Genome Informatics Curator] synonym: "abnormal circulating norepinephrine level" EXACT [] is_a: MT:0003964 ! noradrenaline level is_a: MT:0005418 ! circulating hormone level [Term] id: MT:0005666 name: adipose tissue physiology namespace: Trait.ontology subset: slim_cattle subset: slim_pig is_a: MT:0005375 ! adipose tissue trait [Term] id: MT:0005667 name: circulating leptin level namespace: Trait.ontology def: "aberrant blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [J:34751, MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0005418 ! circulating hormone level [Term] id: MT:0005670 name: white fat physiology namespace: Trait.ontology is_a: MT:0005666 ! adipose tissue physiology [Term] id: MT:0005671 name: response to transplant namespace: Trait.ontology def: "the body's reaction to the grafting of organs, tissues, or cells taken from the same individual for another area of the body or from another individual" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, J:52834, MeSH:National Library of Medicine_Medical Subject Headings] is_a: MT:0001790 ! immune system physiology [Term] id: MT:0005673 name: susceptibility to graft versus host disease namespace: Trait.ontology def: "less likelihood of developing clinical symptoms of anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the a graft versus host reaction, which is an immunological attack mounted by a graft against the host because of tissue incompatibility when immunologically competent cells are transplanted to an immunologically incompetent host" [cwg:Carroll-Ann W. Goldsmith_Mouse Genome Informatics Curator, J:52834, MeSH:National Library of Medicine_Medical Subject Headings] synonym: "decreased susceptibility to graft vs host disease" EXACT [] synonym: "decreased susceptibility to GVHD" EXACT [] is_a: MT:0005671 ! response to transplant [Term] id: MT:0005674 name: arterial trunk division completeness namespace: Trait.ontology def: "any measurable or observable characteristic related to the extent of septation of the path through which blood exits the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] relationship: part_of MT:0000135 ! outflow tract morphology [Term] id: MT:0005675 name: gall bladder size namespace: Trait.ontology def: "reduced size of the gall bladder, the organ that serves as a storage reservoir for bile" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, J:25724] is_a: MT:0005084 ! gall bladder morphology [Term] id: MT:0006000 name: corneal epithelium morphology namespace: Trait.ontology def: "malformation in the one or more of the layers of epithelial cells covering the front of the cornea" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0001312 ! cornea morphology [Term] id: MT:0006001 name: intestinal transit time namespace: Trait.ontology def: "increase or decrease in the time it takes for a bolus of material to pass through the intestine" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0001664 ! digestion [Term] id: MT:0006002 name: small intestinal transit time namespace: Trait.ontology def: "increase or decrease in the time it takes for a bolus of material to pass through the small intestine" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0006001 ! intestinal transit time [Term] id: MT:0006003 name: large intestinal transit time namespace: Trait.ontology def: "increase or decrease in the time it takes for a bolus of material to pass through the large intestine" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0006001 ! intestinal transit time [Term] id: MT:0006004 name: interneuron morphology namespace: Trait.ontology def: "malformation or absence of neurons that exclusively interact with other neurons" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0002882 ! neuron [Term] id: MT:0006005 name: interneuron number namespace: Trait.ontology def: "fewer than normal number of neurons that interact only with other neurons" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0006004 ! interneuron morphology [Term] id: MT:0006006 name: sensory neuron number namespace: Trait.ontology def: "greater than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0000965 ! sensory neuron morphology [Term] id: MT:0006007 name: basal ganglion morphology namespace: Trait.ontology def: "malformation or absence of any of a group of nuclei associated with the ability to carry out willed movements, including the caudate, putamen, nucleus accumbens, globus pallidus, substantia nigra, and subthalamic nucleus" [smb:Susan M. Bello_Mouse Genome Informatics Curator] synonym: "abnormal basal ganglia morphology" EXACT [] is_a: MT:0000783 ! forebrain morphology [Term] id: MT:0006008 name: neurogenesis namespace: Trait.ontology def: "impaired or altered growth or development of neurons" [smb:Susan M. Bello_Mouse Genome Informatics Curator, Taber's Cyclopedic Medical Dictionary_19th edition:ISBN N 0-8036-0655-99] synonym: "abnormal neuronal proliferation" EXACT [] is_a: MT:0003861 ! nervous system development [Term] id: MT:0006009 name: neuronal migration namespace: Trait.ontology def: "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0006008 ! neurogenesis [Term] id: MT:0006011 name: endolymphatic duct morphology namespace: Trait.ontology def: "form or structure of the small membranous canal, connecting with both saccule and utricle of the membranous labyrinth, passing through the aqueduct of vestibule, and terminating in the endolymphatic sac." [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, smb:Susan M. Bello_Mouse Genome Informatics Curator] synonym: "abnormal ductus endolymphaticus" EXACT [] is_a: MT:0000026 ! inner ear morphology [Term] id: MT:0006014 name: endolymphatic sac size namespace: Trait.ontology def: "diameter or volume of the endolymphatic sac" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, J:67072, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0006011 ! endolymphatic duct morphology [Term] id: MT:0006018 name: tympanic membrane morphology namespace: Trait.ontology def: "form or structure of the thin, tense membrane forming the greater part of the lateral wall of the tympanic cavity and separating it from the external acoustic meatus; the tympanic membrane constitutes the boundary between the external and middle ear." [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, J:46639, smb:Susan M. Bello_Mouse Genome Informatics Curator] synonym: "drum membrane morphology" EXACT [] synonym: "membrana tympani morphology" EXACT [] synonym: "myringa morphology" EXACT [] synonym: "myrinx morphology" EXACT [] is_a: MT:0000049 ! middle ear morphology [Term] id: MT:0006019 name: tympanic membrane size namespace: Trait.ontology def: "area of the drum membrane that forms the greater part of the lateral wall of the tympanic cavity" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0006018 ! tympanic membrane morphology [Term] id: MT:0006020 name: tympanic ring size namespace: Trait.ontology def: "diameter or area of the tympanic ring" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0000030 ! tympanic ring morphology [Term] id: MT:0006021 name: Reissner membrane morphology namespace: Trait.ontology def: "form or structure of Reissner's membrane which separates the cochlear duct from the vestibular canal, i.e. the endolymph of the scala media from the perilymph of the scala vestibuli; the Reissner membrane consists of squamous epithelial cells with microvilli toward the ductus, a basement membrane, and a thin layer of connective tissue toward the scala. " [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, smb:Susan M. Bello_Mouse Genome Informatics Curator] synonym: "membrana vestibularis ductus cochlearis morphology" EXACT [] synonym: "morphology of the vestibular wall of cochlear duct" EXACT [] synonym: "paries vestibularis ductus cochlearis morphology" EXACT [] synonym: "Reissner's membrane morphology" EXACT [] synonym: "vestibular membrane morphology" EXACT [] is_a: MT:0000031 ! cochlea morphology [Term] id: MT:0006023 name: Reissner membrane integrity namespace: Trait.ontology def: "susceptibility of the membrane to loss of attachment or collapse" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, smb:Susan M. Bello_Mouse Genome Informatics Curator] synonym: "Reissner's membrane integrity" EXACT [] is_a: MT:0006021 ! Reissner membrane morphology [Term] id: MT:0006025 name: Reissner membrane size namespace: Trait.ontology def: "an increase in the volume of endolymphatic fluid that results in distortion of the vestibular membrane" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, smb:Susan M. Bello_Mouse Genome Informatics Curator] synonym: "distended Reissner's membrane" EXACT [] is_a: MT:0006021 ! Reissner membrane morphology [Term] id: MT:0006026 name: terminal bronchiole tube size namespace: Trait.ontology def: "increased volume of the terminal lung buds" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, J:85546, smb:Susan M. Bello_Mouse Genome Informatics Curator] synonym: "dilated terminal lung buds" EXACT [] is_a: MT:0002268 ! terminal bronchiole morphology [Term] id: MT:0006027 name: respiratory alveologenesis namespace: Trait.ontology def: "a block or reduction in the generation of alveoli" [J:85546, smb:Susan M. Bello_Mouse Genome Informatics Curator] synonym: "reduced alveolar formation" EXACT [] synonym: "reduced alveolarization" EXACT [] is_a: MT:0001176 ! lung development [Term] id: MT:0006028 name: bronchiole branching namespace: Trait.ontology def: "a block or reduction in the morphogenesis of the bronchioles" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, smb:Susan M. Bello_Mouse Genome Informatics Curator] synonym: "reduced bronchiole branching" EXACT [] is_a: MT:0001176 ! lung development [Term] id: MT:0006029 name: sclerotome namespace: Trait.ontology def: "malformation of the one or more of the masses of mesodermal tissue that is derived from the somites and is adjacent to the notochord that give rise to the ribs and vertebrae" [smb:Susan M. Bello_Mouse Genome Informatics Curator, Taber's Cyclopedic Medical Dictionary_19th edition:ISBN N 0-8036-0655-99] is_a: MT:0002113 ! skeleton development [Term] id: MT:0006030 name: otic vesicle formation namespace: Trait.ontology def: "formation of the simple epithelial sac formed from the otic placode that gives rise to the structures of the inner ear" [J:57313, smb:Susan M. Bello_Mouse Genome Informatics Curator] synonym: "otocyst formation" EXACT [] is_a: MT:0003938 ! ear development [Term] id: MT:0006031 name: branchial pouch morphology namespace: Trait.ontology def: "malformation or anomaly in the series of grooves that form between the branchial arches; these endodermal evaginations develop into epithelial tissues and organs" [Gray's Anatomy:ISBN 0-914294-08-3, smb:Susan M. Bello_Mouse Genome Informatics Curator] synonym: "abnormal pharyngeal pouch morphology" EXACT [] is_a: MT:0002085 ! embryonic tissue morphology [Term] id: MT:0006032 name: ureteric bud morphology namespace: Trait.ontology def: "anomaly in the formation or development of the ureteric bud that with the metanephric mesenchyme gives rise to the kidneys " [J:57313, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0000527 ! kidney development [Term] id: MT:0006033 name: external auditory canal morphology namespace: Trait.ontology def: "form or structure of the canal that connects the outer and middle ear" [J:57313, smb:Susan M. Bello_Mouse Genome Informatics Curator] synonym: "external meatus morphology" EXACT [] is_a: MT:0002177 ! outer ear morphology [Term] id: MT:0006034 name: urine myoglobin level namespace: Trait.ontology def: "presence of myoglobin in the urine" [RGD:Rat Genome Database submission, smb:Susan M. Bello_Mouse Genome Informatics Curator] synonym: "myoglobinuria" RELATED [] is_a: MT:0005160 ! urine protein level [Term] id: MT:0006035 name: mitochondrial morphology namespace: Trait.ontology def: "anomalous structure of the cellular organelles responsible for energy production" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0000358 ! cell content/ morphology [Term] id: MT:0006036 name: mitochondrial physiology namespace: Trait.ontology def: "anomalous function of of the cellular organelles responsible for energy production" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0005621 ! cell physiology [Term] id: MT:0006037 name: mitochondrial proliferation namespace: Trait.ontology def: "anomalous reproduction of the cellular organelles responsible for energy production" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0006036 ! mitochondrial physiology [Term] id: MT:0006049 name: semilunar valve integrity namespace: Trait.ontology def: "any measurable characteristic pertaining to the the structural completeness or structural soundness of the valves that gate the flow of blood from the ventricles into the aorta and pulmonary trunk" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] relationship: part_of MT:0000053 ! heart integrity relationship: part_of MT:0002746 ! semilunar valve morphology [Term] id: MT:0006050 name: pulmonary fibrosis namespace: Trait.ontology def: "formation of fibrous tissue within the lung often resulting from inflammation or injury " [RGD:Rat Genome Database submission, smb:Susan M. Bello_Mouse Genome Informatics Curator] synonym: "lung fibrosis" EXACT [] is_a: MT:0001175 ! lung morphology [Term] id: MT:0006051 name: brainstem hemorrhage namespace: Trait.ontology def: "bleeding into the brain stem" [RGD:Rat Genome Database submission, smb:Susan M. Bello_Mouse Genome Informatics Curator] synonym: "brain stem bleeding" EXACT [] synonym: "brain stem hemorrhage" EXACT [] is_a: MT:0001915 ! intracranial hemorrhage [Term] id: MT:0006052 name: cerebellum hemorrhage namespace: Trait.ontology def: "bleeding into the cerebellum" [RGD:Rat Genome Database submission, smb:Susan M. Bello_Mouse Genome Informatics Curator] synonym: "cerebellum bleeding" EXACT [] is_a: MT:0001915 ! intracranial hemorrhage [Term] id: MT:0006053 name: hypothalamus hemorrhage namespace: Trait.ontology def: "bleeding into the hypothalamus" [RGD:Rat Genome Database submission, smb:Susan M. Bello_Mouse Genome Informatics Curator] synonym: "hypothalamic bleeding" EXACT [] is_a: MT:0001915 ! intracranial hemorrhage [Term] id: MT:0006054 name: spinal hemorrhage namespace: Trait.ontology def: "bleeding into the spine" [RGD:Rat Genome Database submission, smb:Susan M. Bello_Mouse Genome Informatics Curator] synonym: "spinal bleeding" EXACT [] synonym: "spinal cord hemorrhage" EXACT [] is_a: MT:0003633 ! nervous system physiology [Term] id: MT:0006055 name: blood vessel endothelial cell morphology namespace: Trait.ontology def: "any measurable or observable characteristic related to the shape, structure, color or pattern of the cells that line the blood vessels" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] synonym: "vascular endothelial cell morphology" RELATED [] synonym: "vascular endothelium morphology" EXACT [] xref: MP:0006005 relationship: part_of MT:0001614 ! blood vessel morphology [Term] id: MT:0006057 name: blood vessel endothelial cell number namespace: Trait.ontology def: "count of the cells that line blood vessels" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] synonym: "vascular endothelial cell number" RELATED [] relationship: part_of MT:0006055 ! blood vessel endothelial cell morphology [Term] id: MT:0006058 name: cerebral infarction size namespace: Trait.ontology def: "decreased size of necrotic area of the cerebrum resulting from a sudden insufficiency of arterial or venous blood supply " [RGD:Rat Genome Database submission, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0003075 ! response to CNS ischemic injury [Term] id: MT:0006061 name: atrium symmetry namespace: Trait.ontology def: "the degree to which the sturcture of the right and left atria reflect each other" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] synonym: "atrial symmetry" RELATED [] relationship: part_of MT:0000508 ! right-sided isomerism relationship: part_of MT:0003105 ! heart atrium morphology [Term] id: MT:0006062 name: vena cava morphology namespace: Trait.ontology def: "any measurable or observable characteristic related to the shape, structure, color or pattern of either of the two largest veins in the body" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] synonym: "caval vein morphology" EXACT [] xref: MP:0006062 is_a: MT:0002725 ! vein morphology [Term] id: MT:0006063 name: inferior vena cava morphology namespace: Trait.ontology def: "any measurable or observable characteristic related to the shape, structure, color or pattern of the principal vein draining blood from the lower portion of the body" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator", RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] synonym: "abnormal inferior caval vein" EXACT [] is_a: MT:0006062 ! vena cava morphology [Term] id: MT:0006064 name: superior vena cava morphology namespace: Trait.ontology def: "any measurable or observable characteristic related to the shape, structure, color or pattern of the principal vein draining blood from the upper portion of the body" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator", RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] synonym: "abnormal superior caval vein" EXACT [] is_a: MT:0006062 ! vena cava morphology [Term] id: MT:0006065 name: heart position namespace: Trait.ontology def: "the location or orientation of the heart within the chest cavity" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] synonym: "cardiac position" RELATED [] relationship: part_of MT:0000266 ! cardiac morphology [Term] id: MT:0006066 name: clearance of atrial thrombosis namespace: Trait.ontology def: "slower removal of a thrombus from the atria of the heart" [RGD:Rat Genome Database submission, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0001855 ! atrial thrombosis [Term] id: MT:0006068 name: horizontal cell morphology namespace: Trait.ontology def: "anomalous structure of the laterally interconnecting neurons in the outer plexiform layer" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0000965 ! sensory neuron morphology is_a: MT:0001325 ! retina morphology [Term] id: MT:0006069 name: retinal neuronal layer morphology namespace: Trait.ontology def: "malformation in any of the neuronal layers that make up the retina, including the ganglion cell, inner plexiform, inner nuclear, outer plexiform, outer nuclear layers, the inner and outer segments" [Gray's Anatomy:ISBN 0-914294-08-3, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0003727 ! retinal layer morphology [Term] id: MT:0006070 name: retinal photoreceptor number namespace: Trait.ontology def: "greater than the expected number of rods and/or cones" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0001004 ! photoreceptor morphology [Term] id: MT:0006071 name: retinal progenitor morphology namespace: Trait.ontology def: "anomaly in the proliferation or differentiation of the cells that give rise to the various cells of the retina" [J:92622, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0001286 ! eye development [Term] id: MT:0006072 name: retinal apoptosis namespace: Trait.ontology def: "increase or decrease in the number of cells in the retina undergoing programmed cell death" [J:92622, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0001325 ! retina morphology [Term] id: MT:0006073 name: retinal bipolar cell morphology namespace: Trait.ontology def: "anomalous structure of the cells that transmit signals from the photoreceptors to retinal amacrine and ganglion cells" [J:92623, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0001325 ! retina morphology [Term] id: MT:0006074 name: retinal rod bipolar cell morphology namespace: Trait.ontology def: "anomalous structure of the bipolar cells that function in low light and transmit signals only through amacrine cells" [J:92623, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0006073 ! retinal bipolar cell morphology [Term] id: MT:0006075 name: retinal cone bipolar cell morphology namespace: Trait.ontology def: "anomalous structure of the retinal bipolar cells that connect to both ganglion and amacrine cells" [J:92623, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0006073 ! retinal bipolar cell morphology [Term] id: MT:0006076 name: circulating homocysteine level namespace: Trait.ontology def: "aberrant concentration in the blood of this amino acid" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] synonym: "abnormal blood serum homocysteine level" EXACT [] is_a: MT:0005311 ! circulating amino acid level [Term] id: MT:0006077 name: inguinal hernia namespace: Trait.ontology def: "hernia through the abdominal wall in the region of the groin known as Hesselbach's triangle" [J:74295, smb:Susan M. Bello_Mouse Genome Informatics Curator, Taber's Cyclopedic Medical Dictionary_19th edition:ISBN N 0-8036-0655-99] is_a: MT:0000757 ! herniated abdominal wall [Term] id: MT:0006078 name: nipple morphology namespace: Trait.ontology def: "malformation of the erectile protuberance at the tip of the mammary gland" [J:92627, smb:Susan M. Bello_Mouse Genome Informatics Curator, Taber's Cyclopedic Medical Dictionary_19th edition:ISBN N 0-8036-0655-99] subset: slim_cattle subset: slim_pig synonym: "teat morphology" EXACT [] is_a: MT:0000627 ! mammary gland morphology [Term] id: MT:0006079 name: stomach tumor namespace: Trait.ontology def: "presence of abnormal rapidly proliferating cells in the stomach, usually in the form of a distinct mass" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] synonym: "gastric tumor" EXACT [] is_a: MT:0002019 ! tumor incidence [Term] id: MT:0006080 name: CNS ischemia namespace: Trait.ontology def: "abnormal incidence of or response to loss of circulation in a region of the brain; may be induced or spontaneous" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] synonym: "CNS stroke" EXACT [] is_a: MT:0003633 ! nervous system physiology [Term] id: MT:0006081 name: spontaneous CNS ischemia namespace: Trait.ontology def: "greater than normal occurrence of loss of circulation in a region of the brain" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] synonym: "increased CNS stroke" EXACT [] is_a: MT:0006080 ! CNS ischemia [Term] id: MT:0006082 name: CNS inflammation namespace: Trait.ontology def: "local accumulation of fluid, plasma proteins, and leukocytes in the brain and/or spinal cord" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] synonym: "encephalomyelitis" EXACT [] is_a: MT:0001846 ! tissue specific inflammatory response is_a: MT:0003633 ! nervous system physiology [Term] id: MT:0006083 name: blood vessel elastic tissue morphology namespace: Trait.ontology def: "any measurable or observable characteristic related to the shape, structure, color or pattern of the tissue that is found in the tunica media of the vessels wall and allows vessels to stretch" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator", RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] synonym: "elastic laminae morphology" EXACT [] synonym: "vascular elastic tissue morphology" RELATED [] relationship: part_of MT:0001614 ! blood vessel morphology [Term] id: MT:0006084 name: circulating phospholipid level namespace: Trait.ontology def: "anomalous concentration in the blood of the fat derivatives in which one fatty acid has been replaced by a phosphate group" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0003949 ! circulating lipid level [Term] id: MT:0006087 name: body mass index namespace: Trait.ontology def: "greater than normal average of a measure of weight for height" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] subset: slim_pig synonym: "increased BMI" EXACT [] is_a: MT:0001259 ! body weight [Term] id: MT:0006088 name: blood-cerebrospinal fluid barrier integrity namespace: Trait.ontology def: "any measurable characteristic pertaining to the the structural completeness or structural soundness group of barriers and transport systems in the choroid plexus located in the lateral, third, and fourth brain ventricles that controls the entrance of substances into the cerebrospinal fluid from the blood" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] comment: this should only be in morphology synonym: "abnormal blood-CSF barrier" EXACT [] relationship: part_of MT:0000085 ! blood-cerebrospinal fluid barrier morphology [Term] id: MT:0006089 name: saccule morphology namespace: Trait.ontology def: "structure or form of the smaller of the two sacs in the vestibule" [J:92940, smb:Susan M. Bello_Mouse Genome Informatics Curator, Taber's Cyclopedic Medical Dictionary_19th edition:ISBN N 0-8036-0655-99] is_a: MT:0004425 ! otolith organ morphology [Term] id: MT:0006090 name: utricle morphology namespace: Trait.ontology def: "structure or form of the larger of the two sacs in the vestibule" [J:92940, smb:Susan M. Bello_Mouse Genome Informatics Curator, Taber's Cyclopedic Medical Dictionary_19th edition:ISBN N 0-8036-0655-99] is_a: MT:0004425 ! otolith organ morphology [Term] id: MT:0006091 name: olfactory epithelium morphology namespace: Trait.ontology def: "malformation in the epithelial cells that line the interior of the nose" [J:92950, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0005499 ! olfactory system morphology [Term] id: MT:0006092 name: olfactory neuron morphology namespace: Trait.ontology def: "malformation in the neurons that are activated by specific odorants" [J:92950, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0000965 ! sensory neuron morphology [Term] id: MT:0006093 name: artery vein separation namespace: Trait.ontology def: "non-fusion of an artery and vein" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] is_obsolete: true [Term] id: MT:0006096 name: retinal bipolar cell number namespace: Trait.ontology def: "count of the cells that transmit signals from the photoreceptors to retinal amacrine and ganglion cells" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, J:65410, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0006073 ! retinal bipolar cell morphology [Term] id: MT:0006097 name: cerebellar lobule formation namespace: Trait.ontology def: "anomaly in the formation of the lobes of the cerebellum" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, J:65410, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0000854 ! cerebellum development [Term] id: MT:0006099 name: granule layer thickness namespace: Trait.ontology def: "reduced thickness of the innermost cortical layer of the cerebellum that contains granule cells" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, J:65410, smb:Susan M. Bello_Mouse Genome Informatics Curator] synonym: "thin internal granule layer" EXACT [] is_a: MT:0000886 ! cerebellar granule layer morphology [Term] id: MT:0006100 name: tegmentum morphology namespace: Trait.ontology def: "any structural alterations or malfunction of the floor of the midbrain which extends from the substantia nigra to the level of the cerebral aqueduct." [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, smb:Susan M. Bello_Mouse Genome Informatics Curator] synonym: "abnormal mesencephalic tegmentum" EXACT [] is_a: MT:0000897 ! midbrain morphology [Term] id: MT:0006102 name: tegmentum size namespace: Trait.ontology def: "reduced size of the floor of the midbrain which extends from the substantia nigra to the level of the cerebral aqueduct" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, smb:Susan M. Bello_Mouse Genome Informatics Curator] synonym: "thin tegmentum" EXACT [] is_a: MT:0006100 ! tegmentum morphology [Term] id: MT:0006103 name: midbrain roof plate morphology namespace: Trait.ontology def: "any structural alterations or malfunction of the mesencephalic roof plate, including the caudal and rostral part of the midbrain roof" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0000897 ! midbrain morphology [Term] id: MT:0006104 name: tectum morphology namespace: Trait.ontology def: "any structural alterations or malfunction of the rostral part of the midbrain roof" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, J:65762, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0006103 ! midbrain roof plate morphology [Term] id: MT:0006105 name: tectum size namespace: Trait.ontology def: "reduced size of the rostral part of the midbrain roof" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, J:65410, smb:Susan M. Bello_Mouse Genome Informatics Curator] synonym: "thin tectum" EXACT [] is_a: MT:0006104 ! tectum morphology [Term] id: MT:0006107 name: atrioventricular canal morphology namespace: Trait.ontology def: "any measurable or observable characteristic related to the shape, structure, color or pattern of the common canal connecting the primordial atrium and ventricle" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] relationship: part_of MT:0000267 ! heart development [Term] id: MT:0006108 name: hindbrain development namespace: Trait.ontology def: "anomaly in the formation or pattering of the caudal region of the brain" [J:93573, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0000913 ! brain development [Term] id: MT:0006109 name: fibrillation namespace: Trait.ontology def: "contraction or quivering of individual cardiac muscle fibers" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] is_a: MT:0001636 ! heartbeat regularity [Term] id: MT:0006110 name: ventricular fibrillation namespace: Trait.ontology def: "contraction or quivering of individual cardiac muscle fibers in the ventricles" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] is_a: MT:0006109 ! fibrillation [Term] id: MT:0006111 name: coronary circulation namespace: Trait.ontology def: "flow of blood through the vessels that supply the heart" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] is_a: MT:0002128 ! blood circulation [Term] id: MT:0006113 name: heart septum morphology namespace: Trait.ontology def: "any measurable or observable characteristic related to the shape, structure, color or pattern of the wall between the atria or ventricles of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] synonym: "cardiac septum morphology" EXACT [] synonym: "heart septal morphology" EXACT [] relationship: part_of MT:0000266 ! cardiac morphology [Term] id: MT:0006114 name: cardiac sounds namespace: Trait.ontology def: "heart sounds resulting from blood flow through the valves or outflow tract" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] is_a: MT:0002128 ! blood circulation [Term] id: MT:0006117 name: aortic valve patency namespace: Trait.ontology def: "any measurable characteristic pertaining to the openness of the valve between the left ventricle and the ascending aorta" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator", RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] relationship: part_of MT:0002747 ! aortic valve integrity [Term] id: MT:0006122 name: mitral valve patency namespace: Trait.ontology def: "any measurable characteristic pertaining to the openness of the valve between the left atrium and left ventricle of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator", RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] relationship: part_of MT:0000286 ! mitral valve integrity [Term] id: MT:0006124 name: tricuspid valve patency namespace: Trait.ontology def: "openness of the valve between the right atrium and the right ventricle of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator", RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] relationship: part_of MT:0002624 ! tricuspid valve integrity [Term] id: MT:0006126 name: outflow tract development namespace: Trait.ontology def: "any measurable or observable characteristics pertaining to the process by which the outflow tract transforms from a simple sphincter into its mature form" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] relationship: part_of MT:0000267 ! heart development [Term] id: MT:0006127 name: great vessel configuration namespace: Trait.ontology def: "any measurable characteristic of the arrangement of the pulmonary vessels and aorta in relation to the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] relationship: part_of MT:0000135 ! outflow tract morphology [Term] id: MT:0006128 name: pulmonary valve patency namespace: Trait.ontology def: "any measurable characteristic pertaining to the openness of the valve between the right ventricle and the pulmonary trunk" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator", RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] relationship: part_of MT:0002748 ! pulmonary valve integrity [Term] id: MT:0006133 name: artery composition namespace: Trait.ontology def: "any measurable or observable characteristic pertaining to the types and ratios of cells or substances within the blood vessels that carry blood away from the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] synonym: "arterial composition" RELATED [] relationship: part_of MT:0002191 ! artery morphology [Term] id: MT:0006135 name: artery patency namespace: Trait.ontology def: "any measurable characteristic pertaining to the openness of the blood vessels that carry blood away from the heart" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] synonym: "arterial patency" RELATED [] is_a: MT:0005412 ! blood vessel patency relationship: part_of MT:0003410 ! artery integrity [Term] id: MT:0006137 name: vein patency namespace: Trait.ontology def: "any measurable characteristic pertaining to the openness of the blood vessels that carry blood towards the heart" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] synonym: "venous patency" RELATED [] is_a: MT:0005412 ! blood vessel patency relationship: part_of MT:0000118 ! vein integrity [Term] id: MT:0006138 name: cardiac function namespace: Trait.ontology def: "ability of the heart to adequately pump blood throughout the body" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] is_a: MT:0001544 ! cardiovascular system physiology [Term] id: MT:0006139 name: rhabdomyoma namespace: Trait.ontology def: "a benign neoplasm of striated muscle " [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0002019 ! tumor incidence [Term] id: MT:0006140 name: cardiac rhabdomyoma namespace: Trait.ontology def: "the most common benign tumor of the myocardium it may be associated with tuberous sclerosis" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0006139 ! rhabdomyoma [Term] id: MT:0006141 name: atrioventricular node conduction namespace: Trait.ontology def: "generation or transfer of cardiac electrical impulses from the atrioventricular node to the atrioventricular bundle" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] is_a: MT:0003137 ! impulse conducting system function [Term] id: MT:0006142 name: sinoatrial node conduction namespace: Trait.ontology def: "the generation or transfer of electrical impulses that trigger contraction of the atria and ventricles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] synonym: "sinus node conduction" EXACT [] is_a: MT:0003137 ! impulse conducting system function [Term] id: MT:0006145 name: legal blindness (sensu H. sapiens) namespace: Trait.ontology def: "the best corrected visual acuity is 20/200, or the visual field is 20 degrees or less" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0002001 ! blindness [Term] id: MT:0006146 name: night blindness namespace: Trait.ontology def: "poor vision at night or in dim light" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0002001 ! blindness [Term] id: MT:0006147 name: monocular blindness namespace: Trait.ontology def: "loss of vision in only one eye, may be transient" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0002001 ! blindness [Term] id: MT:0006148 name: binocular blindness namespace: Trait.ontology def: "loss of vision in both eyes, may be transient" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0002001 ! blindness [Term] id: MT:0006149 name: blurred vision namespace: Trait.ontology def: "loss of visual acuity or ability to distinguish small details" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0002090 ! vision [Term] id: MT:0006150 name: double vision namespace: Trait.ontology def: "two images are perceived when only a single object is present" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] synonym: "diplopia" EXACT [] is_a: MT:0002090 ! vision [Term] id: MT:0006151 name: astigmatism namespace: Trait.ontology def: "the cornea is asymmetrically curved, causing out-of-focus vision" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0001312 ! cornea morphology [Term] id: MT:0006152 name: tunnel vision namespace: Trait.ontology def: "loss of peripheral vision" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0002090 ! vision [Term] id: MT:0006153 name: hypermetropia namespace: Trait.ontology def: "light entering the eye focuses behind the retina, instead of directly on it" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] synonym: "farsighted" EXACT [] synonym: "hyperopia" EXACT [] is_a: MT:0002090 ! vision [Term] id: MT:0006154 name: eye movement relative to the midline namespace: Trait.ontology is_a: MT:0001389 ! eye movements [Term] id: MT:0006156 name: visual pursuit namespace: Trait.ontology is_a: MT:0001389 ! eye movements [Term] id: MT:0006158 name: vertical supranuclear eye movement namespace: Trait.ontology is_a: MT:0001389 ! eye movements [Term] id: MT:0006159 name: ocular albinism namespace: Trait.ontology def: "absence of melanin production in the eye only" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0005172 ! lack of eye pigmentation [Term] id: MT:0006160 name: heterochromatic iridis namespace: Trait.ontology def: "a difference in color between the irises of the two eyes or between parts of one iris" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0005102 ! iris pigmentation [Term] id: MT:0006162 name: eyelid thickness namespace: Trait.ontology def: "increased width of the eyelid" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0001340 ! eyelid morphology [Term] id: MT:0006163 name: ankyloblepharon filiform namespace: Trait.ontology def: "abnormal connection of the upper and lower eyelids formed by fibrous tissue" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0001340 ! eyelid morphology [Term] id: MT:0006164 name: ectropion namespace: Trait.ontology def: "abnormal eversion of the upper or lower eyelid that leaves the eye exposed and dry" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] synonym: "rolled out eyelids" EXACT [] is_a: MT:0001340 ! eyelid morphology [Term] id: MT:0006165 name: entropion namespace: Trait.ontology def: "abnormal inward rolling of the eyelid, most commonly the lower lid" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] synonym: "rolled in eyelids" EXACT [] is_a: MT:0001340 ! eyelid morphology [Term] id: MT:0006166 name: width of eyelid opening namespace: Trait.ontology def: "eyelids open abnormally wide" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0003671 ! eyelid opening [Term] id: MT:0006167 name: eyelid edema namespace: Trait.ontology def: "an abnormal accumulation of fluid in the eyelid" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0001340 ! eyelid morphology is_a: MT:0001785 ! edema [Term] id: MT:0006168 name: epicanthus inversus namespace: Trait.ontology def: "a vertical fold of skin runs from the lower eyelid up either side of the nose" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0001340 ! eyelid morphology [Term] id: MT:0006169 name: eyelid tumor namespace: Trait.ontology def: "presence of abnormal rapidly proliferating cells in the eyelid, usually in the form of a distinct mass" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] synonym: "tumor of the eyelid" EXACT [] is_a: MT:0002019 ! tumor incidence [Term] id: MT:0006170 name: eyelid myxoma namespace: Trait.ontology def: "a benign tumor composed of connective tissue embedded in mucus found in the eyelid" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0003391 ! myxoma is_a: MT:0006169 ! eyelid tumor [Term] id: MT:0006171 name: eyelid neuroma namespace: Trait.ontology def: "a tumor composed of nerve tissue found in the eyelid" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0006169 ! eyelid tumor [Term] id: MT:0006172 name: eyelid lipodermoid namespace: Trait.ontology def: "a congenital, yellowish-white, fatty, benign tumor located beneath the conjunctiva of the eye" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0006169 ! eyelid tumor [Term] id: MT:0006173 name: myeloid dendritic cell morphology namespace: Trait.ontology def: "anomaly in the formation or structure of phagocytic dendritic cells principally found in the epidermis and mucosal epithelium" [J:95147, smb:Susan M. Bello_Mouse Genome Informatics Curator] synonym: "abnormal Langerhans cell morphology/development" EXACT [] is_a: MT:0001601 ! myelopoiesis is_a: MT:0005461 ! dendritic cell morphology/development [Term] id: MT:0006174 name: isthmic organizer morphology namespace: Trait.ontology def: "malformation in the organizing signaling center that forms at the boundary between the midbrain and hindbrain and plays essential role in development of the midbrain and anterior hindbrain" [J:71074, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0000913 ! brain development [Term] id: MT:0006175 name: choroid size namespace: Trait.ontology def: "wasting of the choroid" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0005098 ! choroid morphology [Term] id: MT:0006176 name: choroid integrity namespace: Trait.ontology def: "a retrogressive impairment of function or destruction of the choroid" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] synonym: "choroid dystrophy" EXACT [] is_a: MT:0005098 ! choroid morphology [Term] id: MT:0006177 name: choroid sclerosis namespace: Trait.ontology def: "thickening or hardening of the choroid usually secondary to atrophy" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0005098 ! choroid morphology [Term] id: MT:0006178 name: eye tumor namespace: Trait.ontology def: "presence of abnormal rapidly proliferating cells in the eye, usually in the form of a distinct mass" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0002019 ! tumor incidence [Term] id: MT:0006179 name: choroid tumor namespace: Trait.ontology def: "presence of abnormal rapidly proliferating cells in the choroid, usually in the form of a distinct mass" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0006178 ! eye tumor [Term] id: MT:0006180 name: choroid hemangioma namespace: Trait.ontology def: "a benign tumor of the choroid, originating from the overgrowth of blood vessels" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0002947 ! hemangioma is_a: MT:0006179 ! choroid tumor [Term] id: MT:0006181 name: retina tumor namespace: Trait.ontology def: "presence of abnormal rapidly proliferating cells in the retina, usually in the form of a distinct mass" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0006178 ! eye tumor [Term] id: MT:0006182 name: retinal hemangioma namespace: Trait.ontology def: "a benign tumor of the retina, originating from the overgrowth of blood vessels" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] synonym: "retinal angioma" EXACT [] is_a: MT:0002947 ! hemangioma is_a: MT:0006181 ! retina tumor [Term] id: MT:0006183 name: retinal hamartoma namespace: Trait.ontology def: "tumor-like focal abnormalities of the retina; rarely neoplastic" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0006181 ! retina tumor [Term] id: MT:0006184 name: retinal astrocytoma namespace: Trait.ontology def: "a malignant tumor of nervous tissue composed of well-differentiated astrocytes located in the retina" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0006181 ! retina tumor [Term] id: MT:0006185 name: retinal hemorrhage namespace: Trait.ontology def: "bleeding into the retina" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0001325 ! retina morphology [Term] id: MT:0006186 name: retinal fibrosis namespace: Trait.ontology def: "invasion of fibrous connective tissue into the retina, often resulting from inflammation or injury" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0001325 ! retina morphology [Term] id: MT:0006187 name: retinal deposits namespace: Trait.ontology def: "abnormal accumulation of material on the retina" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0001325 ! retina morphology [Term] id: MT:0006188 name: retinal calcification namespace: Trait.ontology def: "pathologic deposition of calcium salts in the retina" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0006187 ! retinal deposits is_a: MT:0006209 ! intraocular calcification [Term] id: MT:0006190 name: retinal ischemia namespace: Trait.ontology def: "abnormal incidence of or response to loss of circulation in the retina; may be induced or spontaneous" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0005253 ! eye physiology [Term] id: MT:0006191 name: conjunctival deposits namespace: Trait.ontology def: "abnormal accumulation of material on the conjunctiva" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0001310 ! conjunctiva morphology [Term] id: MT:0006192 name: conjunctival blood vessel morphology namespace: Trait.ontology def: "any measurable characteristic pertaining to the the structural completeness or structural soundness of the blood vessel network of the conjunctiva" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] synonym: "conjunctival vascular morphology" RELATED [] synonym: "conjunctival vasculature" RELATED [] xref: MP:0006192 is_a: MT:0001310 ! conjunctiva morphology is_a: MT:0001614 ! blood vessel morphology [Term] id: MT:0006194 name: keratoconjunctivitis namespace: Trait.ontology def: "inflammation of the conjunctiva and cornea" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0001852 ! conjunctivitis [Term] id: MT:0006195 name: position of eyes in the eye socket namespace: Trait.ontology def: "eyes located further back in the eye socket than normal" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0001299 ! eye distance/ position [Term] id: MT:0006196 name: ocular proptosis namespace: Trait.ontology def: "abnormal protrusion of the eyeball" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0001299 ! eye distance/ position [Term] id: MT:0006198 name: enophthalmos namespace: Trait.ontology def: "sinking or retraction of the eye back into the socket" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] synonym: "sunken eyes" EXACT [] is_a: MT:0006195 ! position of eyes in the eye socket [Term] id: MT:0006199 name: hypertropia namespace: Trait.ontology def: "vertical misalignment between the eyes " [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0001299 ! eye distance/ position [Term] id: MT:0006200 name: vitreous body deposition namespace: Trait.ontology def: "abnormal accumulation of material in the vitreous body" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0002699 ! vitreous body [Term] id: MT:0006201 name: vitreous body inflammation namespace: Trait.ontology def: "local accumulation of fluid, plasma proteins, and leukocytes in the vitreous body" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0001851 ! eye inflammation is_a: MT:0002699 ! vitreous body [Term] id: MT:0006202 name: vitreous body hemorrhage namespace: Trait.ontology def: "bleeding into the vitreous body" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0002699 ! vitreous body [Term] id: MT:0006209 name: intraocular calcification namespace: Trait.ontology def: "pathologic deposition of calcium salts in the eye" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0002092 ! eye morphology [Term] id: MT:0006210 name: orbit size namespace: Trait.ontology def: "deviation from the normal size of the orbit" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0005246 ! orbit morphology [Term] id: MT:0006212 name: orbit width namespace: Trait.ontology def: "increased size of the orbits" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0006210 ! orbit size [Term] id: MT:0006213 name: orbit depth namespace: Trait.ontology def: "decrease in the depth of the orbit" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0006210 ! orbit size [Term] id: MT:0006214 name: asymmetrical orbits namespace: Trait.ontology def: "loss of bilateral symmetry in the orbits" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0005246 ! orbit morphology [Term] id: MT:0006215 name: optic disc morphology namespace: Trait.ontology alt_id: MT:0002793 def: "malformation of the area in the retina where all of the axons of the ganglion cells exit the retina to form the optic nerve" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0001330 ! optic nerve morphology is_a: MT:0002864 ! ocular fundus morphology [Term] id: MT:0006216 name: optic disc size namespace: Trait.ontology def: "deviation from the normal size of the optic disc" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0006215 ! optic disc morphology [Term] id: MT:0006219 name: optic nerve integrity namespace: Trait.ontology def: "retrogressive pathologic change of the optic nerve" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0001330 ! optic nerve morphology [Term] id: MT:0006220 name: optic nerve compression namespace: Trait.ontology def: "constriction of the optic nerve" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0001330 ! optic nerve morphology [Term] id: MT:0006221 name: optic nerve fiber number namespace: Trait.ontology def: "less than the normal number of fibers in the optic nerve" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0001330 ! optic nerve morphology [Term] id: MT:0006222 name: optic neuropathy namespace: Trait.ontology def: "damage of the optic nerve due to a blockage of its blood supply, to nutritional deficiencies, or to toxins" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0001330 ! optic nerve morphology [Term] id: MT:0006223 name: optic nerve swelling namespace: Trait.ontology def: "accumulation of an excessive amount of fluid in the optic nerve; usually associated with an increase in intraocular pressure" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] synonym: "papilledema" EXACT [] synonym: "pseudopapilledema" EXACT [] is_a: MT:0001330 ! optic nerve morphology is_a: MT:0001785 ! edema [Term] id: MT:0006224 name: control of horizontal eye movement namespace: Trait.ontology is_a: MT:0001389 ! eye movements [Term] id: MT:0006225 name: ocular rupture namespace: Trait.ontology def: "tearing of the tissues of the eye" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0002092 ! eye morphology [Term] id: MT:0006226 name: iris cell number namespace: Trait.ontology def: "less than the normal number of cells in the iris" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0001322 ! iris morphology [Term] id: MT:0006227 name: iris development namespace: Trait.ontology def: "abnormal development or growth of the iris resulting in abnormal structure of the iris " [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0001286 ! eye development is_a: MT:0001322 ! iris morphology [Term] id: MT:0006228 name: iris size namespace: Trait.ontology def: "wasting of the iris" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0001322 ! iris morphology [Term] id: MT:0006229 name: iris inflammation namespace: Trait.ontology def: "local accumulation of fluid, plasma proteins and leukocytes in the iris" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0001851 ! eye inflammation [Term] id: MT:0006230 name: iris stroma cell number namespace: Trait.ontology def: "less than the normal number of cells in the iris stroma" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0005208 ! iris stroma morphology is_a: MT:0006226 ! iris cell number [Term] id: MT:0006231 name: iris tumor namespace: Trait.ontology def: "presence of abnormal rapidly proliferating cells in the iris, usually in the form of a distinct mass" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0006178 ! eye tumor [Term] id: MT:0006232 name: Lisch nodule namespace: Trait.ontology def: "a focal growth that resembles a neoplasm but results from faulty development in the iris and containing melanocytes" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] synonym: "iris hamartoma" EXACT [] is_a: MT:0006231 ! iris tumor [Term] id: MT:0006233 name: corneal adhesion to iris namespace: Trait.ontology def: "abnormal connection of the iris and cornea" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] synonym: "irido-corneal adhesion" EXACT [] is_a: MT:0001312 ! cornea morphology is_a: MT:0004222 ! synechia [Term] id: MT:0006234 name: iridoschisis namespace: Trait.ontology def: "separation of the anterior iris stroma from the posterior stroma and muscle layers" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0001322 ! iris morphology [Term] id: MT:0006235 name: polycoria namespace: Trait.ontology def: "two or more pupils in one iris each with sphincter muscle." [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0001317 ! pupil morphology [Term] id: MT:0006237 name: choroid blood vessel morphology namespace: Trait.ontology def: "any measurable or observable characteristic related to the shape, structure, color or pattern of the blood vessels of the choroid" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] synonym: "choroid vascular morphology" RELATED [] synonym: "choroid vasculature" RELATED [] is_a: MT:0001614 ! blood vessel morphology is_a: MT:0005098 ! choroid morphology [Term] id: MT:0006238 name: choriocapillaris integrity namespace: Trait.ontology def: "any measurable characteristic pertaining to the the structural completeness or structural soundness of the capillaries forming the inner vascular layer of the choroid of the eye" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] relationship: part_of MT:0000093 ! choroid blood vessel integrity [Term] id: MT:0006240 name: anisocoria namespace: Trait.ontology def: "unequal size of pupils" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0001317 ! pupil morphology [Term] id: MT:0006241 name: placement of pupils namespace: Trait.ontology def: "abnormal location of the pupil so that it is not in the center of the iris" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] synonym: "corectopia" EXACT [] is_a: MT:0001317 ! pupil morphology [Term] id: MT:0006242 name: white pupil namespace: Trait.ontology def: "reflective white mass within the eye that gives the appearance of white pupil" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] synonym: "leukokoria" EXACT [] is_a: MT:0001317 ! pupil morphology [Term] id: MT:0006243 name: pupil dilation reaction to light namespace: Trait.ontology is_a: MT:0002638 ! pupillary reflex [Term] id: MT:0006244 name: involuntary contraction of eyelids namespace: Trait.ontology def: "spasmodic winking caused by the involuntary contraction of an eyelid muscle" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] synonym: "blepharospasm" EXACT [] is_a: MT:0005253 ! eye physiology [Term] id: MT:0006245 name: dislocated lens namespace: Trait.ontology def: "the lens is moved out of position because some or all of the supporting ligaments have broken" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0001303 ! lens morphology [Term] id: MT:0006246 name: tumor of uvea namespace: Trait.ontology def: "presence of abnormal rapidly proliferating cells in the uvea, usually in the form of a distinct mass" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0006178 ! eye tumor [Term] id: MT:0006247 name: intraocular melanoma namespace: Trait.ontology def: "a dark-pigmented, usually malignant tumor arising from a melanocyte occurring in the eye" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0006246 ! tumor of uvea [Term] id: MT:0006248 name: lagopthalmos namespace: Trait.ontology def: "inability to completely close the eye" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0005253 ! eye physiology [Term] id: MT:0006249 name: phthisis bulbi namespace: Trait.ontology def: "small, shrunken, malformed eye usually occurs as the end result of eye disease" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0002697 ! eye size [Term] id: MT:0006250 name: line of Schwalbe morphology namespace: Trait.ontology def: "malformation of the thickened peripheral margin of the vitreous membrane of the cornea" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] synonym: "abnormal Schwalbe's ring" EXACT [] is_a: MT:0005203 ! trabecular meshwork morphology [Term] id: MT:0006251 name: ability to open eyelids namespace: Trait.ontology def: "impaired ability to open the eyelids without any gross defect in eyelid morphology" [ncbi:Matthew Mailman_NCBI request, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0005253 ! eye physiology [Term] id: MT:0006252 name: lateral rectus eye movement namespace: Trait.ontology is_a: MT:0001389 ! eye movements [Term] id: MT:0006253 name: clinodactyly namespace: Trait.ontology def: "abnormal lateral curvature of one or more digits towards or away from each other" [J:98519, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0002110 ! digit morphology [Term] id: MT:0006254 name: thin cerebral cortex namespace: Trait.ontology def: "decreased depth of the mantle covering the surface of the cerebral hemispheres" [J:84683, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0000788 ! cerebral cortex morphology [Term] id: MT:0006256 name: gustatory papillae morphology namespace: Trait.ontology def: "malformation, absence, or atypical size or shape of the papillae that contain taste buds, including the fungiform, foliate, and circumvallate papillae" [J:55127, smb:Susan M. Bello_Mouse Genome Informatics Curator] synonym: "abnormal taste papillae" EXACT [] is_a: MT:0000764 ! tongue epithelium morphology [Term] id: MT:0006257 name: fungiform papillae morphology namespace: Trait.ontology def: "malformation, absence, or atypical size or shape of the mushroom-shaped papillae, which have a single taste bud at the tip, located mostly on the dorsal anterior portion of the tongue" [J:55127, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0006256 ! gustatory papillae morphology [Term] id: MT:0006258 name: circumvallate papillae morphology namespace: Trait.ontology def: "malformation, absence, or atypical size or shape of the large papillae, which have multiple taste buds in the trough surrounding the papillae, located near the base and on the dorsal side of the tongue" [J:55127, smb:Susan M. Bello_Mouse Genome Informatics Curator] synonym: "abnormal vallate papillae" EXACT [] is_a: MT:0006256 ! gustatory papillae morphology [Term] id: MT:0006259 name: foliate papillae morphology namespace: Trait.ontology def: "malformation, absence, or atypical size or shape of the papillae located on the sides of the tongue" [smb:Susan M. Bello_Mouse Genome Informatics Curator, Taber's Cyclopedic Medical Dictionary_19th edition:ISBN N 0-8036-0655-99] is_a: MT:0006256 ! gustatory papillae morphology [Term] id: MT:0006260 name: gustatory papillae taste bud morphology namespace: Trait.ontology def: "malformation, absence, or atypical size or shape of the taste buds located on the gustatory papillae, which includes the fungiform, foliate, and circumvallate papillae" [J:55127, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0001002 ! taste bud morphology [Term] id: MT:0006261 name: annular pancreas namespace: Trait.ontology def: "an abnormal ring or collar of pancreatic tissue that encircles the duodenum" [J:69854, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0001944 ! pancreas morphology [Term] id: MT:0006262 name: testis tumor namespace: Trait.ontology def: "presence of abnormal rapidly proliferating cells in the testis, usually in the form of a distinct mass" [J:60034, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0002019 ! tumor incidence [Term] id: MT:0006263 name: diastolic blood pressure namespace: Trait.ontology def: "the pressure in the arteries between heart beats when the heart is relaxed" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] is_a: MT:0000230 ! blood pressure [Term] id: MT:0006264 name: systolic blood pressure namespace: Trait.ontology def: "pressure in the arteries as the heart contracts and pumps blood into the arteries" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] is_a: MT:0000230 ! blood pressure [Term] id: MT:0006267 name: intercalated disc integrity namespace: Trait.ontology def: "any measurable characteristic pertaining to the the structural completeness or structural soundness of the electron dense junctional complex, at the end to end contacts of cardiac muscle cells, that contains two types of membrane junctions i.e. gap junctions and desmosomes" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] relationship: part_of MT:0000278 ! heart muscle fiber integrity [Term] id: MT:0006268 name: heart muscle desmosome integrity namespace: Trait.ontology def: "any measurable characteristic pertaining to the the structural completeness or structural soundness of one type of membrane junctions found within the intercalated discs that provide mechanical integrity and prevent separation of adjacent cells during contraction of cardiac tissue" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] synonym: "cardiac desmosome integrity" RELATED [] relationship: part_of MT:0000278 ! heart muscle fiber integrity [Term] id: MT:0006269 name: mammary gland growth during pregnancy namespace: Trait.ontology def: "anomaly in the extensive and rapid branching of the mammary ducts, expansion of mammary epithelium in the stroma between the ducts with or without abnormalities in nipple maturation " [llw2:Linda Washburn_Mouse Genome Informatics Curator] is_a: MT:0000628 ! mammary gland development [Term] id: MT:0006270 name: mammary gland growth during lactation namespace: Trait.ontology def: "anomaly in the final stage of mammary growth that occurs during the start of lactation" [llw2:Linda Washburn_Mouse Genome Informatics Curator] is_a: MT:0000628 ! mammary gland development [Term] id: MT:0006271 name: involution of the mammary gland namespace: Trait.ontology def: "anomaly in the process during which mammary glands suspend milk protein production, the mammary alveolar structures collapse and secretory epithelial cells are lost" [llw2:Linda Washburn_Mouse Genome Informatics Curator] is_a: MT:0000628 ! mammary gland development [Term] id: MT:0006272 name: renal organic anion excretion namespace: Trait.ontology def: "anomaly in the ability of the kidneys to eliminate organic acids (represented by the prototypical substrate para-aminohippurate (PAH))" [J:108655, smb:Susan M. Bello_Mouse Genome Informatics Curator] synonym: "abnormal renal organic anion secretion" EXACT [] is_a: MT:0005555 ! kidney excretion [Term] id: MT:0006273 name: renal organic cation excretion namespace: Trait.ontology def: "anomaly in the ability of the kidneys to eliminate organic bases (represented by the prototypical substrate tetraethylammonium (TEA))" [smb:Susan M. Bello_Mouse Genome Informatics Curator] synonym: "abnormal renal organic cation secretion" EXACT [] is_a: MT:0005555 ! kidney excretion [Term] id: MT:0006274 name: urine sodium level namespace: Trait.ontology def: "any change in the level of excretion of sodium in the urine" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0001757 ! urine chemistry [Term] id: MT:0006276 name: autonomic nervous system physiology namespace: Trait.ontology def: "anomaly in the function of the sensory and motor neurons that run between the central nervous system (especially the hypothalamus and medulla oblongata) and various internal organs (heart, lungs, endocrine and exocrine glands), responsible for controlling involuntary bodily functions" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, smb:Susan M. Bello_Mouse Genome Informatics Curator, Taber's Cyclopedic Medical Dictionary_19th edition:ISBN N 0-8036-0655-99] is_a: MT:0003633 ! nervous system physiology [Term] id: MT:0006277 name: parasympathetic nervous system physiology namespace: Trait.ontology def: "anomaly in the function of the craniosacral portion of the autonomic nervous system" [anna:Anna V. Anagnostopoulos_Mouse Genome Informatics Curator, J:78031, Taber's Cyclopedic Medical Dictionary_19th edition:ISBN N 0-8036-0655-99] is_a: MT:0006276 ! autonomic nervous system physiology [Term] id: MT:0006279 name: limb development namespace: Trait.ontology def: "anomaly in the formation of the limbs" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0003937 ! limbs/digits/tail development [Term] id: MT:0006280 name: digit development namespace: Trait.ontology def: "anomaly in the formation of the digits" [J:70592, smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0000572 ! autopod morphology [Term] id: MT:0006281 name: tail development namespace: Trait.ontology def: "anomaly in the formation of the tail" [smb:Susan M. Bello_Mouse Genome Informatics Curator] is_a: MT:0003937 ! limbs/digits/tail development [Term] id: MT:0006282 name: posterior horn morphology namespace: Trait.ontology def: "anomalous structure of the dorsal gray matter of the spinal cord" [J:77764, smb:Susan M. Bello_Mouse Genome Informatics Curator] synonym: "abnormal dorsal horn morphology" EXACT [] synonym: "abnormal posterior column morphology" EXACT [] synonym: "abnormal posterior cornu morphology" EXACT [] is_a: MT:0000955 ! spinal cord morphology [Term] id: MT:0006283 name: medulloblastoma namespace: Trait.ontology def: "a solid, cancerous tumor originating in the cerebellum of the brain and of primitive neuroectodermal origin " [rbabiuk:Randall Babiuk_Mouse Genome Informatics Curator, smb:Susan M. Bello_Mouse Genome Informatics Curator] synonym: "primitive neuroendocrine tumor" EXACT [] is_a: MT:0002019 ! tumor incidence [Term] id: MT:0007000 name: heart apex orientation namespace: Trait.ontology def: "the angle of the top of the heart in relation the the rostral-caudal axis of the body" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] synonym: "cardiac apex directionality" RELATED [] relationship: part_of MT:0006065 ! heart position [Term] id: MT:0007001 name: endocardial cushion morphology namespace: Trait.ontology def: "any measurable or observable characteristic related to the shape, structure, color or pattern of the mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal; these mounds eventually fuse to form the valves between the right and left atrioventricular orifices" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] relationship: part_of MT:0000267 ! heart development [Term] id: MT:0007002 name: endocardial cushion size namespace: Trait.ontology def: "the physical dimensions, proportions, magnitude, or extent of the mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal; these mounds fuse to form the valves between the right and left atrioventricular orifices" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] relationship: part_of MT:0007001 ! endocardial cushion morphology [Term] id: MT:0007003 name: endocardial cushion thickness namespace: Trait.ontology def: "the breadth of the mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal; these mounds fuse to form the valves between the right and left atrioventricular orifices" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] relationship: part_of MT:0007002 ! endocardial cushion size [Term] id: MT:0007004 name: heart tube looping integrity namespace: Trait.ontology def: "any measurable characteristic pertaining to the completeness or soundness of the process by which the embryonic heart tube bends to transform from a straight tube into the final folded configuration of the adult heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] relationship: part_of MT:0000269 ! heart tube looping morphogenesis [Term] id: MT:0007005 name: atrioventricular canal completeness namespace: Trait.ontology def: "any measurable or observable characteristic pertaining to the wholeness of the common canal connecting the primordial atrium and ventricle" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] relationship: part_of MT:0006107 ! atrioventricular canal morphology [Term] id: MT:0007007 name: atrioventricular canal configuration namespace: Trait.ontology def: "any measurable characteristic of the arrangement of the common canal connecting the primordial atrium and ventricle" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] relationship: part_of MT:0006107 ! atrioventricular canal morphology [Term] id: MT:0007009 name: atrium septum configuration namespace: Trait.ontology def: "any measurable or observable characteristic of the arrangement of the wall separating the upper chambers of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] synonym: "atrial septal configuration" RELATED [] relationship: part_of MT:0007081 ! atrium septum morphology [Term] id: MT:0007010 name: cardiomyocyte number namespace: Trait.ontology def: "count of muscle cells in the heart as a whole or in any substructure of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] synonym: "heart muscle cell number" RELATED [] relationship: part_of MT:0000061 ! heart muscle fiber morphology [Term] id: MT:0007012 name: mitral valve configuration namespace: Trait.ontology def: "any measurable characteristic of the arrangement of the valve between the left atrium and the left ventricle of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] relationship: part_of MT:0000033 ! mitral valve morphology [Term] id: MT:0007013 name: mitral valve completeness namespace: Trait.ontology def: "any measurable or observable characteristic pertaining to the wholeness of the valve between the left atrium and the left ventricle of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] relationship: part_of MT:0000286 ! mitral valve integrity [Term] id: MT:0007014 name: tricuspid valve completeness namespace: Trait.ontology def: "any measurable or observable characteristic pertaining to the wholeness of the valve between the right atrium and the right ventricle of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] relationship: part_of MT:0002624 ! tricuspid valve integrity [Term] id: MT:0007016 name: tricuspid valve configuration namespace: Trait.ontology def: "any measurable characteristic of the arrangement of the valve between the right atrium and the right ventricle of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] relationship: part_of MT:0000036 ! tricuspid valve morphology [Term] id: MT:0007017 name: aortic valve completeness namespace: Trait.ontology def: "any measurable or observable characteristic pertaining to the wholeness of the valve between the left ventricle and the ascending aorta" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] relationship: part_of MT:0002747 ! aortic valve integrity [Term] id: MT:0007019 name: aortic valve configuration namespace: Trait.ontology def: "any measurable or observable characteristic of the arrangement of the valve between the left ventricle and the ascending aorta" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] relationship: part_of MT:0000040 ! aortic valve morphology [Term] id: MT:0007021 name: pulmonary valve completeness namespace: Trait.ontology def: "any measurable or observable characteristic pertaining to the wholeness of the valve between the right ventricle and the pulmonary trunk" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] relationship: part_of MT:0002748 ! pulmonary valve integrity [Term] id: MT:0007022 name: pulmonary valve configuration namespace: Trait.ontology def: "any measurable or observable characteristic of the arrangement of the valve between the right ventricle and the pulmonary trunk" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] relationship: part_of MT:0000044 ! pulmonary valve morphology [Term] id: MT:0007024 name: left atrium configuration namespace: Trait.ontology def: "any measurable characteristic of the arrangement of the left upper chamber of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] relationship: part_of MT:0000020 ! left atrium morphology [Term] id: MT:0007025 name: left atrium completeness namespace: Trait.ontology def: "any measurable or observable characteristic pertaining to the wholeness of the left upper chamber of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] synonym: "left atrial completeness" RELATED [] relationship: part_of MT:0003923 ! left atrium integrity [Term] id: MT:0007026 name: left atrium weight namespace: Trait.ontology def: "mass of the left upper chamber of the heart times gravity" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] synonym: "left atrial weight" RELATED [] relationship: part_of MT:0000012 ! left atrium size [Term] id: MT:0007027 name: right atrium weight namespace: Trait.ontology def: "mass of the right upper chamber of the heart times gravity" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] synonym: "right atrial weight" RELATED [] relationship: part_of MT:0000005 ! right atrium size [Term] id: MT:0007028 name: heart weight namespace: Trait.ontology def: "mass of the heart times gravity" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] subset: slim_chkn subset: slim_pig synonym: "cardiac weight" RELATED [] is_a: MT:0005406 ! heart size [Term] id: MT:0007029 name: heart dimensions namespace: Trait.ontology def: "any measurable characteristic of the spacial extent of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] synonym: "cardiac dimensions" RELATED [] is_a: MT:0005406 ! heart size [Term] id: MT:0007030 name: left ventricle volume namespace: Trait.ontology alt_id: MT:0007092 def: "physical bulk of or total amount of space encompassed by the left lower chamber of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] synonym: "left ventricle mass" EXACT [] relationship: part_of MT:0002753 ! left ventricle size [Term] id: MT:0007031 name: left ventricle weight namespace: Trait.ontology def: "mass of the left lower chamber of the heart times gravity" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] relationship: part_of MT:0002753 ! left ventricle size [Term] id: MT:0007032 name: right ventricle volume namespace: Trait.ontology alt_id: MT:0007093 def: "physical bulk of or total amount of space encompassed by the right lower chamber of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] synonym: "right ventricle mass" EXACT [] synonym: "right ventricular mass" RELATED [] synonym: "right ventricular volume" RELATED [] relationship: part_of MT:0002754 ! right ventricle size [Term] id: MT:0007033 name: right ventricle weight namespace: Trait.ontology def: "mass of the right lower chamber of the heart times gravity" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] subset: slim_chkn synonym: "right ventricular weight" RELATED [] relationship: part_of MT:0002754 ! right ventricle size [Term] id: MT:0007035 name: pericardium integrity namespace: Trait.ontology def: "any measurable characteristic pertaining to the the structural completeness or structural soundness of the fibroserous membrane covering the heart and beginning of the great vessels" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator", RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] comment: By this I mean measures that determine if the structure has all of the required parts, if there are any extra parts, and if there are any holes or disease present. - smb synonym: "pericardial integrity" RELATED [] relationship: part_of MT:0000053 ! heart integrity relationship: part_of MT:0000288 ! pericardium morphology [Term] id: MT:0007036 name: pericardium configuration namespace: Trait.ontology def: "any measurable characteristic of the arrangement of the pericardium in relation to the heart and/or great vessels" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] synonym: "pericardial configuration" RELATED [] relationship: part_of MT:0000288 ! pericardium morphology [Term] id: MT:0007037 name: endocardial cushion completeness namespace: Trait.ontology def: "any measurable or observable characteristic pertaining to the wholeness of the mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal; these mounds fuse to form the valves between the right and left atrioventricular orifices" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] relationship: part_of MT:0000297 ! endocardial cushion integrity [Term] id: MT:0007038 name: endocardial configuration namespace: Trait.ontology def: "any measurable characteristic of the arrangement of the mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal; these mounds eventually fuse to form the valves between the right and left atrioventricular orifices" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] relationship: part_of MT:0007001 ! endocardial cushion morphology [Term] id: MT:0007041 name: heart tube configuration namespace: Trait.ontology def: "any measurable characteristic of the arrangement of the early embryonic heart in relation to itself and the surrounding tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] relationship: part_of MT:0000125 ! heart tube morphology [Term] id: MT:0007042 name: heart tube completeness namespace: Trait.ontology is_obsolete: true [Term] id: MT:0007044 name: aorta integrity namespace: Trait.ontology def: "any measurable characteristic pertaining to the the structural completeness or structural soundness of the main trunk of the systemic arteries" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] synonym: "aortic integrity" RELATED [] is_a: MT:0003410 ! artery integrity relationship: part_of MT:0000272 ! aorta morphology [Term] id: MT:0007046 name: aorta completeness namespace: Trait.ontology def: "any measurable or observable characteristic pertaining to the wholeness of the main trunk of the systemic arteries" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] synonym: "aortic completeness" RELATED [] relationship: part_of MT:0007044 ! aorta integrity [Term] id: MT:0007047 name: aorta configuration namespace: Trait.ontology def: "any measurable characteristic of the arrangement of the main trunk of the systemic arteries" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] synonym: "aortic configuration" RELATED [] relationship: part_of MT:0000272 ! aorta morphology [Term] id: MT:0007048 name: aorta elastic tissue composition namespace: Trait.ontology def: "any measurable or observable characteristic pertaining to the types and ratios of substances within the slender connective tissue fiber in aortic tissue characterized by great elasticity" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] synonym: "aortic elastic fiber composition" RELATED [] relationship: part_of MT:0003211 ! aorta elastic tissue morphology [Term] id: MT:0007049 name: aorta elastic tissue integrity namespace: Trait.ontology def: "any measurable characteristic pertaining to the the structural completeness or structural soundness of the slender connective tissue fiber in aortic tissue characterized by great elasticity" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] synonym: "aortic elastic fiber integrity" RELATED [] is_a: MT:0000101 ! blood vessel elastic tissue integrity relationship: part_of MT:0003211 ! aorta elastic tissue morphology [Term] id: MT:0007050 name: aortic arch completeness namespace: Trait.ontology def: "any measurable or observable characteristic pertaining to the wholeness of the portion of the descending aorta proceeding from the arch of the aorta and extending to the diaphram" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] relationship: part_of MT:0000099 ! aotic arch integrity [Term] id: MT:0007052 name: aortic arch configuration namespace: Trait.ontology def: "any measurable characteristic of the arrangement of the portion of the descending aorta proceeding from the arch of the aorta and extending to the diaphram" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] relationship: part_of MT:0004113 ! aortic arch morphology [Term] id: MT:0007053 name: coronary artery integrity namespace: Trait.ontology def: "any measurable characteristic pertaining to the the structural completeness or structural soundness of the arteries that branch from the aorta to supply blood to the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] is_a: MT:0003410 ! artery integrity relationship: part_of MT:0004111 ! coronary artery morphology [Term] id: MT:0007054 name: pulmonary artery integrity namespace: Trait.ontology def: "any measurable characteristic pertaining to the the structural completeness or structural soundness of the artery that arises from the right ventricle and conveys unaerated blood to the lungs" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] is_a: MT:0003410 ! artery integrity relationship: part_of MT:0000484 ! pulmonary artery morphology [Term] id: MT:0007055 name: kidney blood vessel integrity namespace: Trait.ontology def: "any measurable characteristic pertaining to the the structural completeness or structural soundness of the blood vessel network of the organ of excretion" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] synonym: "integrity of the renal vasculature" RELATED [] synonym: "renal vascular integrity" RELATED [] is_a: MT:0000088 ! blood vessel integrity relationship: part_of MT:0000530 ! kidney blood vessel morphology [Term] id: MT:0007056 name: lung blood vessel integrity namespace: Trait.ontology def: "any measurable characteristic pertaining to the the structural completeness or structural soundness of the blood vessels of the organ of respiration" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator", RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] synonym: "integrity of the pulmonary vasculature" RELATED [] synonym: "lung vascular integrity" RELATED [] relationship: part_of MT:0004007 ! lung blood vessel morphology [Term] id: MT:0007057 name: vascular smooth muscle integrity namespace: Trait.ontology def: "any measurable characteristic pertaining to the the structural completeness or structural soundness of the nonstriated, involuntary muscle tissue of the blood vessels" [RGD:ms "Mary Shimoyama, Rat Genome Database Program Manager"] relationship: part_of MT:0000088 ! blood vessel integrity relationship: part_of MT:0005592 ! blood vessel smooth muscle morphology [Term] id: MT:0007058 name: blood-brain barrier function namespace: Trait.ontology is_a: MT:0000249 ! blood vessel physiology [Term] id: MT:0007059 name: blood-cerebrospinal fluid barrier function namespace: Trait.ontology is_a: MT:0000249 ! blood vessel physiology [Term] id: MT:0007060 name: electrical depolarization of atria namespace: Trait.ontology is_a: MT:0003137 ! impulse conducting system function [Term] id: MT:0007061 name: electrical depolarization of ventricle namespace: Trait.ontology is_a: MT:0003137 ! impulse conducting system function [Term] id: MT:0007062 name: time between ventricular depolarization and repolarization namespace: Trait.ontology is_a: MT:0003137 ! impulse conducting system function [Term] id: MT:0007063 name: atrial muscle contractility namespace: Trait.ontology is_a: MT:0002972 ! cardiac muscle contractility [Term] id: MT:0007064 name: excitation-contraction coupling namespace: Trait.ontology is_a: MT:0003137 ! impulse conducting system function [Term] id: MT:0007065 name: time between atrial depolarization and ventricle depolarization namespace: Trait.ontology is_a: MT:0003137 ! impulse conducting system function [Term] id: MT:0007066 name: arterial elasticity trait namespace: Trait.ontology is_a: MT:0000249 ! blood vessel physiology [Term] id: MT:0007067 name: carotid-brachial pulse wave velocity namespace: Trait.ontology is_a: MT:0007066 ! arterial elasticity trait [Term] id: MT:0007068 name: carotid-femoral pulse wave velocity namespace: Trait.ontology is_a: MT:0007066 ! arterial elasticity trait [Term] id: MT:0007069 name: carotid-radial pulse wave velocity namespace: Trait.ontology is_a: MT:0007066 ! arterial elasticity trait [Term] id: MT:0007070 name: forward pressure wave amplitude namespace: Trait.ontology is_a: MT:0007066 ! arterial elasticity trait [Term] id: MT:0007071 name: reflected pressure wave amplitude namespace: Trait.ontology is_a: MT:0007066 ! arterial elasticity trait [Term] id: MT:0007072 name: left ventricle internal dimension namespace: Trait.ontology def: "any measurable characteristic of the spacial extent of the inside of the left lower chamber of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] relationship: part_of MT:0002753 ! left ventricle size [Term] id: MT:0007073 name: left ventricle internal diameter, diastole namespace: Trait.ontology is_obsolete: true [Term] id: MT:0007074 name: left ventricle internal diameter, systole namespace: Trait.ontology is_obsolete: true [Term] id: MT:0007075 name: left ventricle wall thickness namespace: Trait.ontology def: "cross sectional width from the interior to the exterior edge of the wall of the left lower chamber of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] relationship: part_of MT:0003921 ! left ventricle morphology [Term] id: MT:0007076 name: left atrium dimension namespace: Trait.ontology def: "any measurable characteristic of the spacial extent of the left upper lower chamber of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] synonym: "left atrial dimension" RELATED [] relationship: part_of MT:0000012 ! left atrium size [Term] id: MT:0007077 name: right atrium dimension namespace: Trait.ontology def: "any measurable characteristic of the spacial extent of the left upper lower chamber of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] relationship: part_of MT:0000005 ! right atrium size [Term] id: MT:0007078 name: right ventricle internal dimension namespace: Trait.ontology def: "any measurable characteristic of the spacial extent of the inside of the right lower chamber of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] synonym: "right ventricular internal dimension" RELATED [] relationship: part_of MT:0002754 ! right ventricle size [Term] id: MT:0007079 name: right ventricle internal diameter, diastole namespace: Trait.ontology is_obsolete: true [Term] id: MT:0007080 name: right ventricle internal diameter, systole namespace: Trait.ontology is_obsolete: true [Term] id: MT:0007081 name: atrium septum morphology namespace: Trait.ontology def: "any measurable or observable characteristic related to the shape, structure, color or pattern of the wall between the upper chambers of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] synonym: "atrial septal morphology" RELATED [] synonym: "atrial septum morphology" RELATED [] relationship: part_of MT:0003105 ! heart atrium morphology relationship: part_of MT:0006113 ! heart septum morphology [Term] id: MT:0007082 name: ventricle septum morphology namespace: Trait.ontology def: "any measurable or observable characteristic related to the shape, structure, color or pattern of the wall between the lower chambers of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] synonym: "interventricular septal thickness" RELATED [] synonym: "ventricle septal morphology" RELATED [] synonym: "ventricular septal morphology" RELATED [] synonym: "ventricular septum morphology" RELATED [] relationship: part_of MT:0005294 ! heart ventricle morphology relationship: part_of MT:0006113 ! heart septum morphology [Term] id: MT:0007083 name: ventricle septum completeness namespace: Trait.ontology def: "any measurable or observable characteristic pertaining to the wholeness of the wall between the lower chambers of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] synonym: "interventricular septal completeness" RELATED [] synonym: "ventricular septal completeness" RELATED [] relationship: part_of MT:0000281 ! ventricle septum integrity [Term] id: MT:0007084 name: ventricle septum configuration namespace: Trait.ontology def: "any measurable or observable characteristic of the arrangement of the wall separating the lower chambers of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] synonym: "interventricular septal configuration" RELATED [] synonym: "ventricular septal configuration" RELATED [] relationship: part_of MT:0007082 ! ventricle septum morphology [Term] id: MT:0007086 name: ventricle septum thickness namespace: Trait.ontology synonym: "interventricular septal thickness" RELATED [] synonym: "ventricular septal thickness" RELATED [] relationship: part_of MT:0007082 ! ventricle septum morphology [Term] id: MT:0007087 name: left ventricle posterior wall thickness namespace: Trait.ontology def: "cross sectional width from the interior to the exterior edge of the wall closest to the back of the left ventricle" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] is_a: MT:0007075 ! left ventricle wall thickness [Term] id: MT:0007088 name: right ventricle wall thickness namespace: Trait.ontology def: "cross sectional width from the interior to the exterior edge of the wall of the right lower chamber of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] relationship: part_of MT:0003920 ! right ventricle morphology [Term] id: MT:0007089 name: right ventricle posterior wall thickness namespace: Trait.ontology def: "cross sectional width from the interior to the exterior edge of the wall closest to the back of the right lower chamber of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] is_a: MT:0007088 ! right ventricle wall thickness [Term] id: MT:0007090 name: aorta size namespace: Trait.ontology def: "the physical dimensions, proportions, magnitude, or extent of the main trunk of the systemic arteries" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] synonym: "aortic size" RELATED [] relationship: part_of MT:0000272 ! aorta morphology [Term] id: MT:0007091 name: aorta root diameter namespace: Trait.ontology def: "length of the straight line segment passing through the center of the portion of the aorta attached to the atrioventricular fibrous rings and myocardium" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] synonym: "aortic root diameter" RELATED [] relationship: part_of MT:0007090 ! aorta size [Typedef] id: is_a name: is a namespace: Trait.ontology subset: slim_cattle subset: slim_chkn subset: slim_pig [Typedef] id: part_of name: part_of namespace: Trait.ontology subset: slim_cattle subset: slim_chkn subset: slim_pig is_transitive: true